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https://www.readbyqxmd.com/read/28829735/differential-vector-competency-of-aedes-albopictus-populations-from-the-americas-for-zika-virus
#1
Sasha R Azar, Christopher M Roundy, Shannan L Rossi, Jing H Huang, Grace Leal, Ruimei Yun, Ildefonso Fernandez-Salas, Christopher J Vitek, Igor A D Paploski, Pamela M Stark, Jeremy Vela, Mustapha Debboun, Martin Reyna, Uriel Kitron, Guilherme S Ribeiro, Kathryn A Hanley, Nikos Vasilakis, Scott C Weaver
To evaluate the potential role of Aedes albopictus (Skuse) as a vector of Zika virus (ZIKV), colonized mosquitoes of low generation number (≤ F5) from Brazil, Houston, and the Rio Grande Valley of Texas engorged on viremic mice infected with ZIKV strains originating from Senegal, Cambodia, Mexico, Brazil, or Puerto Rico. Vector competence was established by monitoring infection, dissemination, and transmission potential after 3, 7, and 14 days of extrinsic incubation. Positive saliva samples were assayed for infectious titer...
August 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28827128/alexithymic-trait-is-associated-with-right-ifg-and-pre-sma-activation-in-non-emotional-response-inhibition-in-healthy-subjects
#2
Gioele Gavazzi, Stefano Orsolini, Arianna Rossi, Andrea Bianchi, Emanuele Bartolini, Emanuele Nicolai, Andrea Soricelli, Marco Aiello, Stefano Diciotti, Maria Pia Viggiano, Mario Mascalchi
Event-related fMRI studies have explored emotion inhibitory processes in alexithymic individuals and have demonstrated abnormal BOLD activations in the processing of emotional stimuli. So far, no study has explored the relationship between the alexithymic trait and the general inhibition process, namely utilizing stimuli devoid of emotional valence. In this study 26 healthy subjects were administered the Toronto Alexithymic Scale (TAS-20) questionnaire to measure the alexithymic trait and performed an event related Go/Nogo task build up with letters during fMRI acquisition...
August 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28827010/measures-of-impulsivity-in-parkinson-s-disease-decrease-after-dbs-in-the-setting-of-stable-dopamine-therapy
#3
P Justin Rossi, Sol De Jesus, Christopher W Hess, Daniel Martinez-Ramirez, Kelly D Foote, Aysegul Gunduz, Michael S Okun
INTRODUCTION: Recent evidence suggests deep brain stimulation can alter impulse control. Our objective was to prospectively evaluate the effects of subthalamic nucleus (STN) and globus pallidus internus (GPi) deep brain stimulation on impulse control disorders (ICDs) in the setting of a conservative dopamine reduction strategy. METHODS: Patients (n = 37) undergoing de novo, unilateral STN or GPi DBS lead implantation were evaluated pre-operatively and 6-12 months post-operatively for the presence of ICDs using the Questionnaire for Impulsivity in Parkinson's disease (QUIP) and by clinical interview...
August 9, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28826881/plga-peg-nanoparticles-as-potential-tool-for-off-label-use-of-n-acetylcysteine-in-the-treatment-of-diastrophic-dysplasia
#4
Enrica Chiesa, Luca Monti, Chiara Paganini, Rossella Dorati, Bice Conti, Tiziana Modena, Antonio Rossi, Ida Genta
Potential off-label therapeutic role of N-Acetylcysteine (N-Ac) was recently demonstrated in the treatment of diastrophic dysplasia (DTD) using mutant DTD mice; its main drawback is the rapid clearance from blood due to the liver metabolism. Our goal was to investigate the potential of PEGylated polylactide-co-glycolide (PLGA-PEG) based nanoparticles (NPs) in order to improve in vivo biodistribution performances and N-Ac pharmacokinetic profile after subcutaneous administration in mice. Results suggest that N-Ac can be effectively loaded into NPs (about 99 μg/mg NPs) using a suitably optimized nanoprecipitation method...
August 18, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28826688/carbapenem-resistant-enterobacteriaceae-in-patients-admitted-to-the-emergency-department-new-risk-factors-and-occurrence-in-patients-coming-directly-from-the-community
#5
Matias Chiarastelli Salomão, Thais Guimarães, Daniel Fernandes Duailibi, Maria Beatriz Moliterno Perondi, Leila Suemi Harima Letaif, Amanda Cardoso Montal, Flavia Rossi, Ana Paula Cury, Alberto José da Silva Duarte, Anna S Levin, Icaro Boszczowski
BACKGROUND: Carbapenem-resistant Enterobacteriaceae (CRE) have been reported worldwide and are associated with high mortality rates. Intestinal colonization acts as a reservoir and fosters resistance mechanisms exchange. AIM: To investigate the prevalence of patients harboring CRE on hospital admission, risk factors associated and the acquisition rate within the emergency department (ED). METHODS: We conducted a cross-sectional with 676 patients consecutively admitted to the ED study during the months of May to July 2016...
August 18, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/28823051/imaging-features-of-glenoid-bare-spot-in-a-pediatric-population
#6
Sahlya Djebbar, Zehava Sadka Rosenberg, Erin Fitzgerald Alaia, Christoph Agten, Jonathan Zember, Ignacio Rossi
OBJECTIVE: The bare spot (BaS) is a central, well-circumscribed focal defect in the glenoid articular surface, with reported adult incidence of 1-2%. We aimed to reassess MRI features of BaS in the pediatric population and determine its etiology. MATERIALS AND METHODS: A retrospective search of our database from June 2014 to October 2015 was performed for shoulder MRI in patients between 5 and 25 years and then subdivided into four groups: group 1, 5-10 years; group 2, 10-15 years; group 3, 15-18 years; group 4, 20-25 years...
August 19, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28822983/impulsivity-in-parkinson-s-disease-is-associated-with-altered-subthalamic-but-not-globus-pallidus-internus-activity
#7
Peter Justin Rossi, Jonathan B Shute, Enrico Opri, Rene Molina, Corinna Peden, Oscar Castellanos, Kelly D Foote, Aysegul Gunduz, Michael S Okun
BACKGROUND: A significant subset of patients with Parkinson's disease (PD) suffer from impulse control disorders (ICDs). A hallmark feature of many ICDs is the pursuit of rewarding behaviours despite negative consequences. Recent evidence implicates the subthalamic nucleus (STN) and globus pallidus internus (GPi) in reward and punishment processing, and deep brain stimulation (DBS) of these structures has been associated with changes in ICD symptoms. METHODS: We tested the hypothesis that in patients with PD diagnosed with ICD, neurons in the STN and GPi would be more responsive to reward-related stimuli and less responsive to loss-related stimuli...
August 19, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28821897/erratum-to-signal-intensity-at-unenhanced-t1-weighted-magnetic-resonance-in-the-globus-pallidus-and-dentate-nucleus-after-serial-administrations-of-a-macrocyclic-gadolinium-based-contrast-agent-in-children
#8
Maria Camilla Rossi Espagnet, Bruno Bernardi, Luca Pasquini, Lorenzo Figà-Talamanca, Paolo Tomà, Antonio Napolitano
No abstract text is available yet for this article.
August 18, 2017: Pediatric Radiology
https://www.readbyqxmd.com/read/28821324/from-the-editor-s-desk-september-2017
#9
Richard Moreau, Ramon Bataller, Thomas Berg, Jessica Zucmann-Rossi, Rajiv Jalan
No abstract text is available yet for this article.
September 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28820016/why-we-stay-with-our-social-partners-neural-mechanisms-of-stay-leave-decision-making
#10
Amber Heijne, Filippo Rossi, Alan G Sanfey
How do we decide to keep interacting (e.g., stay) with a social partner or to switch (e.g., leave) to another? This paper investigated the neural mechanisms of stay/leave decision-making. We hypothesized that these decisions fit within a framework of value-based decision-making, and explored four potential mechanisms underlying a hypothesized bias to stay. Twenty-six participants underwent functional Magnetic Resonance Imaging (fMRI) while completing social and nonsocial versions of a stay/leave decision-making task...
August 18, 2017: Social Neuroscience
https://www.readbyqxmd.com/read/28819027/combination-therapy-with-bispecific-antibodies-and-pd-1-blockade-enhances-the-antitumor-potency-of-t-cells
#11
Chien-Hsing Chang, Yang Wang, Rongxiu Li, Diane L Rossi, Donglin Liu, Edmund A Rossi, Thomas M Cardillo, David M Goldenberg
The DOCK-AND-LOCK (DNL®) method is a platform technology that combines recombinant engineering and site-specific conjugation to create multispecific, multivalent antibodies of defined composition with retained bioactivity. We have applied DNL® to generate a novel class of trivalent bispecific antibodies (bsAbs), each comprising an anti-CD3 scFv covalently conjugated to a stabilized dimer of different anti-tumor Fabs. Here we report the further characterization of two such constructs, (E1)-3s and (14)-3s, which activate T cells and target Trop-2- and CEACAM5-expressing cancer cells, respectively...
August 17, 2017: Cancer Research
https://www.readbyqxmd.com/read/28818409/endomyocardial-fibrosis-a-rare-case-of-diastolic-heart-failure-in-a-european-caucasian-elderly-woman
#12
Luca Conte, Majlinda Fejzo, Andrea Rossi, Marco Zuin, Loris Roncon
No abstract text is available yet for this article.
July 27, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28817615/genotoxic-effects-of-roundup-full-ii%C3%A2-on-lymphocytes-of-chaetophractus-villosus-xenarthra-mammalia-in-vitro-studies
#13
Juan Pablo Luaces, Luis Francisco Rossi, Mónica Gabriela Chirino, Melanie Browne, María Susana Merani, Marta Dolores Mudry
In Argentina, Chaetophractus villosus has a wide distribution that overlaps with agricultural areas where soybean is the predominant crop. In such areas the pesticide Roundup Full II® (RU) is widely applied. The genotoxic effect of its active ingredient glyphosate (RU is 66.2% glyphosate) on the peripheral blood lymphocytes of C. villosus was tested over a range of concentrations (280, 420, 560, 1120 μmol/L). Culture medium without glyphosate served as negative control, while medium containing mitomycin C served as positive control...
2017: PloS One
https://www.readbyqxmd.com/read/28816070/correction-to-rossi-e-et%C3%A2-al-it-s-a-gut-feeling-escherichia-coli-biofilm-formation-in-the-gastrointestinal-tract-environment
#14
(no author information available yet)
No abstract text is available yet for this article.
August 17, 2017: Critical Reviews in Microbiology
https://www.readbyqxmd.com/read/28816051/lipid-stabilized-water-oil-interfaces-studied-by-micro-focusing-small-angle-x-ray-scattering
#15
Emanuela Di Cola, Kristian Torbensen, Ilaria Clemente, Federico Rossi, Sandra Ristori, Ali Abou-Hassan
Water in oil (w/o) simple emulsions are dispersed micro-confined systems which find applications in many areas of advanced materials and biotechnology, such as food industry, drug delivery and cosmetics, to name but a few. In these systems, the structural and chemical properties of the boundary layer at the w/o interface are of paramount importance to determine functionality and stability. Recently, microfluidic methods have emerged as a valuable tool to fabricate monodisperse emulsion droplets. Due to the intrinsic flexibility of microfluidics, different interfaces can be obtained, and general principles governing the interfacial stability are needed to guide the experimental approach...
August 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28815334/clinical-characteristics-of-patient-selection-and-imaging-predictors-of-outcome-in-solid-tumors-treated-with-checkpoint-inhibitors
#16
REVIEW
Sabrina Rossi, Luca Toschi, Angelo Castello, Fabio Grizzi, Luigi Mansi, Egesta Lopci
The rapidly evolving knowledge on tumor immunology and the continuous implementation of immunotherapy in cancer have recently led to the FDA and EMA approval of several checkpoint inhibitors as immunotherapic agents in clinical practice. Anti-CTLA-4, anti-PD-1, and anti-PDL-1 antibodies are becoming standard of care in advanced melanoma, as well as in relapsed or metastatic lung and kidney cancer, demonstrating higher and longer response compared to standard chemotherapy. These encouraging results have fostered the evaluation of these antibodies either alone or in combination with other therapies in several dozen clinical trials for the treatment of multiple tumor types...
August 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28814986/2-deoxy-d-glucose-restore-glucocorticoid-sensitivity-in-acute-lymphoblastic-leukemia-via-modification-of-n-linked-glycosylation-in-an-oxygen-tension-independent-manner
#17
Zaira Leni, Paulina Ćwiek, Valeriya Dimitrova, Andrea S Dulcey, Nicola Zamboni, Cedric Simillion, Geetha Rossi, Kurt Leibundgut, Alexandre Arcaro
In childhood acute lymphoblastic leukemia, treatment failure is associated with resistance to glucocorticoid agents. Resistance to this class of drugs represents one of the strongest indicators of poor clinical outcome. We show that leukemic cells, which are resistant to the glucocorticoid drug methylprednisolone, display a higher demand of glucose associated with a deregulation of metabolic pathways, in comparison to sensitive cells. Interestingly, a combinatorial treatment of glucocorticoid and the glucose analog 2-deoxy-D-glucose displayed a synergistic effect in methylprednisolone-resistant cells, in an oxygen tension-independent manner...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28814941/a-survey-on-the-perception-of-allergy-specialists-about-the-reimbursed-grass-pollen-tablets-for-seasonal-allergic-rhinitis-in-italy
#18
Ilaria Massaro, Oliviero Rossi, Cristoforo Incorvaia, Carlo Lombardi
BACKGROUND: Sublingual immunotherapy (SLIT) is a feasible option to classical subcutaneous immunotherapy to treat respiratory allergy and is increasingly prescribed in Europe. However, the lack of reimbursement may limit its prescription. In 2015, the 5-grass pollen tablets was authorized by the European Medicine Agency to treat grass-pollen induced rhinitis and was approved in Italy for full reimbursement. We evaluated the opinions of allergy specialists after the availability of the reimbursed 5-grass pollen tablets...
2017: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/28814009/preliminary-results-toward-a-naturally-controlled-multi-synergistic-prosthetic-hand
#19
Matteo Rossi, Cosimo Della Santina, Cristina Piazza, Giorgio Grioli, Manuel Catalano, Antonio Biechi
Robotic hands embedding human motor control principles in their mechanical design are getting increasing interest thanks to their simplicity and robustness, combined with good performance. Another key aspect of these hands is that humans can use them very effectively thanks to the similarity of their behavior with real hands. Nevertheless, controlling more than one degree of actuation remains a challenging task. In this paper, we take advantage of these characteristics in a multi-synergistic prosthesis. We propose an integrated setup composed of Pisa/IIT SoftHand 2 and a control strategy which simultaneously and proportionally maps the human hand movements to the robotic hand...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28813981/a-magnetic-compatible-supernumerary-robotic-finger-for-functional-magnetic-resonance-imaging-fmri-acquisitions-device-description-and-preliminary-results
#20
Irfan Hussain, Emiliano Santarnecchi, Andrea Leo, Emiliano Ricciardi, Simone Rossi, Domenico Prattichizzo
The Supernumerary robotic limbs are a recently introduced class of wearable robots that, differently from traditional prostheses and exoskeletons, aim at adding extra effectors (i.e., arms, legs, or fingers) to the human user, rather than substituting or enhancing the natural ones. However, it is still undefined whether the use of supernumerary robotic limbs could specifically lead to neural modifications in brain dynamics. The illusion of owning the part of body has been already proven in many experimental observations, such as those relying on multisensory integration (e...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
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