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JOURNAL ARTICLE
The impact of critical thinking skills on student pharmacist GPA at a historically Black university.
Estela Lajthia, Miranda G Law, Jamila Jorden, Bryanna Haynes, Mary K Awuonda, Muhammad Habib, Youness R Karodeh, La'Marcus T Wingate
INTRODUCTION: Limited information is available regarding whether malleable factors such as critical thinking skills are associated with academic performance among underrepresented minority pharmacy students. This study assessed the relationship between critical thinking skills and grade point average (GPA) among pharmacy students attending a Historically Black College. METHODS: A cross sectional study design was utilized to evaluate the association between student's GPA and critical thinking skills...
April 8, 2024: Currents in Pharmacy Teaching & Learning
#22
JOURNAL ARTICLE
Estela Melguizo Herrera, Yolima Manrique Anaya, Claudia Torres Contreras, Raquel Rivera Carvajal, Cesar Hueso Montoro
OBJECTIVE: To validate the content of the indicators proposed from the Nursing Outcome Classification in a care plan for delirium management in older adults. METHODS: Content validity study, conducted under the expert judgment technique. The procedure was developed in five moments: organization of indicators that respond to the nursing outcome classification for delirium management, support with literature of the indicators that responds to the result, selection of experts, establishment of agreements, and discussion...
November 2023: Investigación y Educación en Enfermería
#23
JOURNAL ARTICLE
Eliut Pérez Sánchez, Adriana Corona-Pérez, Omar Arroyo-Helguera, Ida Soto Rodríguez, Senobia Rosalía Cruz Lumbreras, Jorge Rodríguez-Antolín, Estela Cuevas Romero, Leticia Nicolás-Toledo
Stress is often associated with anxiety and depressive symptoms in adolescents. Stress is associated with components of metabolic syndrome and inflammation. The present study hypothesizes that aldosterone, more than corticosterone, promotes chronic stress-hepatic steatosis and fibrosis, as well as renal inflammation and fibrosis in young adult rats. Thirty-two young adult male Wistar rats of 51 days old were divided into four groups (n = 8 per group): Control (C), chronic unpredictable mild stress (CUMS), control plus vehicle (C plus veh), CUMS plus eplerenone, a selective aldosterone blocker (CUMS plus EP)...
April 7, 2024: Journal of Molecular Histology
#24
JOURNAL ARTICLE
José Antonio Curiel, Estela de Vega, Susana Langa, Ángela Peirotén, José María Landete
The elucidation of the physicochemical properties of glycosidases is essential for their subsequent technological application, which may include saccharide hydrolysis processes and oligosaccharide synthesis. As the application of cloning, purification and enzymatic immobilization methods can be time consuming and require a heavy financial investment, this study has validated the recombinant production of the set of Lacticaseibacillus rhamnosus fucosidases fused with Usp45 and SpaX anchored to the cell wall of Lacticaseibacillus cremoris subsp cremoris MG1363, with the aim of avoiding the purification and stabilization steps...
April 4, 2024: Enzyme and Microbial Technology
#25
JOURNAL ARTICLE
Estela Area-Gomez, Eric A Schon
The "amyloid cascade" hypothesis of Alzheimer's disease (AD) pathogenesis invokes the accumulation in the brain of plaques (containing the amyloid-β protein precursor [AβPP] cleavage product amyloid-β [Aβ]) and tangles (containing hyperphosphorylated tau) as drivers of pathogenesis. However, the poor track record of clinical trials based on this hypothesis suggests that the accumulation of these peptides is not the only cause of AD. Here, an alternative hypothesis is proposed in which the AβPP cleavage product C99, not Aβ, is the main culprit, via its role as a regulator of cholesterol metabolism...
April 3, 2024: Journal of Alzheimer's Disease: JAD
#26
JOURNAL ARTICLE
Oak Z Chi, Xia Liu, Harvey Fortus, Guy Werlen, Estela Jacinto, Harvey R Weiss
The manifestations of tuberous sclerosis complex (TSC) in humans include epilepsy, autism spectrum disorders (ASD) and intellectual disability. Previous studies suggested the linkage of TSC to altered cerebral blood flow and metabolic dysfunction. We previously reported a significant elevation in cerebral blood flow in an animal model of TSC and autism of young Eker rats. Inhibition of the mammalian target of rapamycin (mTOR) by rapamycin could restore normal oxygen consumption and cerebral blood flow. In this study, we investigated whether inhibiting a component of the mTOR signaling pathway, p70 ribosomal S6 kinase (S6K1), would yield comparable effects...
April 4, 2024: Neuromolecular Medicine
#27
JOURNAL ARTICLE
Hilario Martines-Arano, Alejandra Valdivia-Flores, Juan Castillo-Cruz, Blanca Estela García-Pérez, Carlos Torres-Torres
A significant modification in photoinduced energy transfer in cancer cells is reported by the assistance of a dynamic modulation of the beam size of laser irradiation. Human lung epithelial cancer cells in monolayer form were studied. In contrast to the quantum and thermal ablation effect promoted by a standard focused Gaussian beam, a spatially modulated beam can caused around 15% of decrease in the ablation threshold and formation of a ring-shaped distribution of the photothermal transfer effect. Optical irradiation was conducted in A549 cells by a 532 nm single-beam emerging from a Nd:YVO4 system...
April 3, 2024: Biomedical Physics & Engineering Express
#28
John Ethan Householder, Florian Wittmann, Jochen Schöngart, Maria Teresa Fernandez Piedade, Wolfgang J Junk, Edgardo Manuel Latrubesse, Adriano Costa Quaresma, Layon O Demarchi, Guilherme de S Lobo, Daniel P P de Aguiar, Rafael L Assis, Aline Lopes, Pia Parolin, Iêda Leão do Amaral, Luiz de Souza Coelho, Francisca Dionízia de Almeida Matos, Diógenes de Andrade Lima Filho, Rafael P Salomão, Carolina V Castilho, Juan Ernesto Guevara-Andino, Marcelo de Jesus Veiga Carim, Oliver L Phillips, Dairon Cárdenas López, William E Magnusson, Daniel Sabatier, Juan David Cardenas Revilla, Jean-François Molino, Mariana Victória Irume, Maria Pires Martins, José Renan da Silva Guimarães, José Ferreira Ramos, Domingos de Jesus Rodrigues, Olaf S Bánki, Carlos A Peres, Nigel C A Pitman, Joseph E Hawes, Everton José Almeida, Luciane Ferreira Barbosa, Larissa Cavalheiro, Márcia Cléia Vilela Dos Santos, Bruno Garcia Luize, Evlyn Márcia Moraes de Leão Novo, Percy Núñez Vargas, Thiago Sanna Freire Silva, Eduardo Martins Venticinque, Angelo Gilberto Manzatto, Neidiane Farias Costa Reis, John Terborgh, Katia Regina Casula, Flávia R C Costa, Euridice N Honorio Coronado, Abel Monteagudo Mendoza, Juan Carlos Montero, Ted R Feldpausch, Gerardo A Aymard C, Chris Baraloto, Nicolás Castaño Arboleda, Julien Engel, Pascal Petronelli, Charles Eugene Zartman, Timothy J Killeen, Lorena Maniguaje Rincón, Beatriz S Marimon, Ben Hur Marimon-Junior, Juliana Schietti, Thaiane R Sousa, Rodolfo Vasquez, Bonifacio Mostacedo, Dário Dantas do Amaral, Hernán Castellanos, Marcelo Brilhante de Medeiros, Marcelo Fragomeni Simon, Ana Andrade, José Luís Camargo, William F Laurance, Susan G W Laurance, Emanuelle de Sousa Farias, Maria Aparecida Lopes, José Leonardo Lima Magalhães, Henrique Eduardo Mendonça Nascimento, Helder Lima de Queiroz, Roel Brienen, Pablo R Stevenson, Alejandro Araujo-Murakami, Tim R Baker, Bruno Barçante Ladvocat Cintra, Yuri Oliveira Feitosa, Hugo F Mogollón, Janaína Costa Noronha, Flávia Rodrigues Barbosa, Rainiellen de Sá Carpanedo, Joost F Duivenvoorden, Miles R Silman, Leandro Valle Ferreira, Carolina Levis, José Rafael Lozada, James A Comiskey, Freddie C Draper, José Julio de Toledo, Gabriel Damasco, Nállarett Dávila, Roosevelt García-Villacorta, Alberto Vicentini, Fernando Cornejo Valverde, Alfonso Alonso, Luzmila Arroyo, Francisco Dallmeier, Vitor H F Gomes, Eliana M Jimenez, David Neill, Maria Cristina Peñuela Mora, Fernanda Antunes Carvalho, Fernanda Coelho de Souza, Kenneth J Feeley, Rogerio Gribel, Marcelo Petratti Pansonato, Marcos Ríos Paredes, Jos Barlow, Erika Berenguer, Kyle G Dexter, Joice Ferreira, Paul V A Fine, Marcelino Carneiro Guedes, Isau Huamantupa-Chuquimaco, Juan Carlos Licona, Toby Pennington, Boris Eduardo Villa Zegarra, Vincent Antoine Vos, Carlos Cerón, Émile Fonty, Terry W Henkel, Paul Maas, Edwin Pos, Marcos Silveira, Juliana Stropp, Raquel Thomas, Doug Daly, William Milliken, Guido Pardo Molina, Ima Célia Guimarães Vieira, Bianca Weiss Albuquerque, Wegliane Campelo, Thaise Emilio, Alfredo Fuentes, Bente Klitgaard, José Luis Marcelo Pena, Priscila F Souza, J Sebastián Tello, Corine Vriesendorp, Jerome Chave, Anthony Di Fiore, Renato Richard Hilário, Luciana de Oliveira Pereira, Juan Fernando Phillips, Gonzalo Rivas-Torres, Tinde R van Andel, Patricio von Hildebrand, William Balee, Edelcilio Marques Barbosa, Luiz Carlos de Matos Bonates, Hilda Paulette Dávila Doza, Ricardo Zárate Gómez, Therany Gonzales, George Pepe Gallardo Gonzales, Bruce Hoffman, André Braga Junqueira, Yadvinder Malhi, Ires Paula de Andrade Miranda, Linder Felipe Mozombite-Pinto, Adriana Prieto, Agustín Rudas, Ademir R Ruschel, Natalino Silva, César I A Vela, Stanford Zent, Egleé L Zent, Angela Cano, Yrma Andreina Carrero Márquez, Diego F Correa, Janaina Barbosa Pedrosa Costa, Bernardo Monteiro Flores, David Galbraith, Milena Holmgren, Michelle Kalamandeen, Marcelo Trindade Nascimento, Alexandre A Oliveira, Hirma Ramirez-Angulo, Maira Rocha, Veridiana Vizoni Scudeller, Rodrigo Sierra, Milton Tirado, Maria Natalia Umaña, Geertje van der Heijden, Emilio Vilanova Torre, Manuel Augusto Ahuite Reategui, Cláudia Baider, Henrik Balslev, Sasha Cárdenas, Luisa Fernanda Casas, William Farfan-Rios, Cid Ferreira, Reynaldo Linares-Palomino, Casimiro Mendoza, Italo Mesones, Germaine Alexander Parada, Armando Torres-Lezama, Ligia Estela Urrego Giraldo, Daniel Villarroel, Roderick Zagt, Miguel N Alexiades, Edmar Almeida de Oliveira, Karina Garcia-Cabrera, Lionel Hernandez, Walter Palacios Cuenca, Susamar Pansini, Daniela Pauletto, Freddy Ramirez Arevalo, Adeilza Felipe Sampaio, Elvis H Valderrama Sandoval, Luis Valenzuela Gamarra, Hans Ter Steege
No abstract text is available yet for this article.
April 2, 2024: Nature Ecology & Evolution
#29
JOURNAL ARTICLE
Raquel Sánchez-Varo, Alexander López-Salas, Rasiel Beltran-Casanueva, Estela Díaz-Sánchez, Jose Erik Alvarez-Contino, Miguel Angel Barbancho-Fernández, Pedro Serrano-Castro, Kjell Fuxe, Dasiel O Borroto-Escuela, Natalia García-Casares, Manuel Narváez
BACKGROUND: Spatial memory deficits and reduced neuronal survival contribute to cognitive decline seen in the aging process. Current treatments are limited, emphasizing the need for innovative therapeutic strategies. This research explored the combined effects of intranasally co-administered galanin receptor 2 (GALR2) and neuropeptide Y1 receptor (NPY1R) agonists, recognized for their neural benefits, on spatial memory, neuronal survival, and differentiation in adult rats. After intranasal co-delivery of the GALR2 agonist M1145 and a NPY1R agonist to adult rats, spatial memory was tested with the object-in-place task 3 weeks later...
March 28, 2024: Behavioral and Brain Functions: BBF
#30
REVIEW
Eliseo Albert, Estela Giménez, Rafael Hernani, José Luis Piñana, Carlos Solano, David Navarro
A solid body of scientific evidence supports the assumption that Torque teno virus (TTV) DNA load in the blood compartment may behave as a biomarker of immunosuppression in solid organ transplant recipients; in this clinical setting, high or increasing TTV DNA levels precede the occurrence of infectious complications, whereas the opposite anticipates the development of acute rejection. The potential clinical value of the TTV DNA load in blood to infer the risk of opportunistic viral infection or immune-related (i...
March 17, 2024: Viruses
#31
JOURNAL ARTICLE
Estela Sangüesa, Emilio Fernández-Egea, Julia Concha, Cristina B García, María Pilar Ribate
Managing schizophrenia with clozapine poses a significant challenge due to prevalent therapeutic failures. The increasing interest in personalized medicine underscores the importance of integrating pharmacogenetic information for effective pharmacotherapeutic monitoring in patients. The objective of this study was to explore the correlation between DRD2 , HTR2A , SLC6A4 , CYP1A2 , and ABCB1 polymorphisms and clozapine response in 100 patients with Treatment-Resistant Schizophrenia. Different scales such as the Positive and Negative Syndrome Scale (PANSS), the Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS), the Global Assessment of Functioning Scale (GAF), the Brief Negative Symptom Scale (BNSS), and pharmacokinetic parameters were used to analyse the efficacy of the treatment...
March 7, 2024: Biomedicines
#32
JOURNAL ARTICLE
Pablo Flores-Paco, Alicia Vargas-Aliaga, María Geraldina Guevara, Ignacio Lopera, Lucía Rodríguez Ruiz, María López-Herrero, Juan Adrián Camús, Javier López-González, Elizabeth Inga-Saavedra, Marina Montero, Isidoro Barneto, Mª Auxiliadora Gómez-España, Estela Ruiz, Marta Ruza, Ana Armenta, Amalia Palacios, Juan R De La Haba-Rodríguez, Enrique Aranda
INTRODUCTION: Palliative WBRT is the main treatment for multiple BMs. Recent studies report no benefit in survival after WBRT compared to palliative supportive care in patients (pts) with poor prognosis. A new era of systemic treatment strategies based on targeted therapies are improving the prognosis of patients with BMs. The purpose of this study is to develop a prognostic score in palliative pts with BMs who undergo WBRT in this new setting. METHODS: 239 pts with BMs who received palliative WBRT between 2013-2022 in our center were analyzed retrospectively...
March 27, 2024: Journal of Neuro-oncology
#33
JOURNAL ARTICLE
Yair Zloof, Estela Derazne, Maya Braun, Rivka Friedland, Oded Scheuerman, Amir Shlaifer, Lotem Goldberg
No abstract text is available yet for this article.
March 27, 2024: JAMA Dermatology
#34
JOURNAL ARTICLE
Fátima Marín, Júlia Canet-Hermida, Vanessa Bianchi, Jiil Chung, Katharina Wimmer, William Foulkes, Vanesa Pérez-Alonso, Nerea Domínguez-Pinilla, Constantino Sábado, Felisa Vázquez-Gómez, Antonio Molinés, Victoria Fioravantti, Estela Carrasco, Lucie Stengs, Melissa Edwards, Logine Negm, Anirban Das, Melyssa Aronson, Ángela Pastor, Daniel Rueda, Luis Ignacio González-Granado, Uri Tabori, Gabriel Capellá, Marta Pineda
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) is a rare and extraordinarily penetrant childhood-onset cancer predisposition syndrome. Genetic diagnosis is often hampered by the identification of mismatch repair (MMR) variants of unknown significance and difficulties in PMS2 analysis, the most frequently mutated gene in CMMRD. We present the validation of a robust functional tool for CMMRD diagnosis and the characterization of microsatellite instability (MSI) patterns in blood and tumors...
March 26, 2024: Clinical Chemistry
#35
JOURNAL ARTICLE
Sussanne Reyes, Patricio Peirano, Sheila Gahagan, Estela Blanco, Cecilia Algarín
OBJECTIVE: The objective of this study was to assess whether inhibitory task performance in adolescence could be prospectively related to weight gain in young adulthood. We proposed that this association would differ according to the BMI group in adolescence. METHODS: A total of 318 adolescents performed the anti-saccade task, and 530 completed the Stroop test. Accuracy and reaction time were assessed for each incentive type (neutral, loss, and reward) in the anti-saccade task and for each trial type (control and incongruent trials) in the Stroop test...
April 2024: Obesity
#36
JOURNAL ARTICLE
Loukianos S Rallidis, Christos V Rizos, Konstantinos A Papathanasiou, George Liamis, Ioannis Skoumas, Anastasia Garoufi, Genovefa Kolovou, Konstantinos Tziomalos, Emmanouil Skalidis, Vasileios Kotsis, George Sfikas, Michalis Doumas, Panagiotis Anagnostis, Vaia Lambadiari, Vasiliki Giannakopoulou, Estela Kiouri, Georgia Anastasiou, Ermioni Petkou, Iosif Koutagiar, Achilleas Attilakos, Vana Kolovou, Evangelos Zacharis, Christina Antza, Charalambos Koumaras, Chrysoula Boutari, Evangelos Liberopoulos
AIMS: Three physical signs, namely tendon xanthomas, corneal arcus and xanthelasma, have been associated with heterozygous familial hypercholesterolemia (heFH). The prevalence and clinical significance of these signs are not well established among contemporary heFH individuals. This study explored the frequency as well as the association of these physical signs with prevalent atherosclerotic cardiovascular disease (ASCVD) in heFH individuals. METHODS: Data from the Hellenic Familial Hypercholesterolemia Registry were applied for this analysis...
March 20, 2024: Journal of Cardiovascular Medicine
#37
JOURNAL ARTICLE
Caitlin M Tilsed, Barzan A Sadiq, Tyler E Papp, Phurin Areesawangkit, Kenji Kimura, Estela Noguera-Ortega, John Scholler, Nicholas Cerda, Haig Aghajanian, Adrian Bot, Barbara Mui, Ying Tam, Drew Weissman, Carl H June, Steven M Albelda, Hamideh Parhiz
The use of lipid nanoparticles (LNP) to encapsulate and deliver mRNA has become an important therapeutic advance. In addition to vaccines, LNP-mRNA can be used in many other applications. For example, targeting the LNP with anti-CD5 antibodies (CD5/tLNP) can allow for efficient delivery of mRNA payloads to T cells to express protein. As the percentage of protein expressing T cells induced by an intravenous injection of CD5/tLNP is relatively low (4-20%), our goal was to find ways to increase mRNA-induced translation efficiency...
March 26, 2024: Proceedings of the National Academy of Sciences of the United States of America
#38
JOURNAL ARTICLE
Daniela Maria Escobar-Espinal, Airam Nicole Vivanco-Estela, Núbia Barros, Maurício Dos Santos Pereira, Francisco Silveira Guimaraes, Elaine Del Bel, Glauce C Nascimento
Trigeminal neuralgia (TN) is an intense and debilitating orofacial pain. The gold standard treatment for TN is carbamazepine. This antiepileptic drug provides pain relief with limited efficacy and side effects. To study the antinociceptive potential of cannabidiol (CBD) and its fluorinated analog PECS-101 (former HUF-101), we induced unilateral chronic constriction injury of the infraorbital nerve (IoN-CCI) in male Wistar rats. Seven days of treatment with CBD (30 mg/kg), PECS-101 (3, 10, and 30 mg/kg), or carbamazepine (10 and 30 mg/kg) reduced allodynia and hyperalgesia responses...
March 19, 2024: Progress in Neuro-psychopharmacology & Biological Psychiatry
#39
JOURNAL ARTICLE
Joshua P Plotnik, Adam E Richardson, Haopeng Yang, Estela Rojas, Velitchka Bontcheva, Colleen Dowell, Sydney Parsons, Ashley Wilson, Vida Ravanmehr, Christine Will, Paul Jung, Haizhong Zhu, Sarathy Karunan Partha, Sanjay C Panchal, Raghuveer Singh Mali, Frederick J Kohlhapp, Ryan A McClure, Cyril Y Ramathal, Mariam D George, Manisha Jhala, Nathaniel L Elsen, Wei Qiu, Russell A Judge, Chin Pan, Anthony Mastracchio, Jared Henderson, Jonathan A Meulbroek, Michael R Green, William N Pappano
The activated B cell (ABC) subset of diffuse large B cell lymphoma (DLBCL) is characterized by chronic B cell receptor signaling and associated with poor outcomes when treated with standard therapy. In ABC-DLBCL, MALT1 is a core enzyme that is constitutively activated by stimulation of the B cell receptor or gain-of-function mutations in upstream components of the signaling pathway, making it an attractive therapeutic target. We discovered a novel small molecule inhibitor, ABBV-MALT1, that potently shuts down B cell signaling selectively in ABC-DLBCL preclinical models leading to potent cell growth and xenograft inhibition...
March 20, 2024: Molecular Cancer Therapeutics
#40
JOURNAL ARTICLE
Estela Giménez, Roberto Gozalbo-Rovira, Eliseo Albert, José Luis Piñana, Carlos Solano, David Navarro
Cytomegalovirus (CMV) DNA in plasma is mainly unprotected and highly fragmented. The size of the amplicon largely explains the variation in CMV DNA loads quantified across PCR platforms. In this proof-of-concept study, we assessed whether the CMV DNA fragmentation profile may vary across allogeneic hematopoietic stem cell transplant recipients (allo-SCT), within the same patient over time, or is affected by letermovir (LMV) use. A total of 52 plasma specimens from 14 nonconsecutive allo-SCT recipients were included...
March 2024: Journal of Medical Virology
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