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https://www.readbyqxmd.com/read/29792364/current-evidence-in-the-stability-of-medicines-in-dose-administration-aids-implications-for-patient-safety
#1
Estela R García, Stefanie Thalhauser, Hèctor R Loscertales, Pilar Modamio, Cecilia F Lastra, Eduardo L Mariño
As the elderly population and polypharmacy are increasing, it is predicted that interventions to enhance medication adherence, as dose administration aids (DAA), will grow too. One of the limitations of repackaging medicines into DAA is to assure the stability of medicines, and, therefore, their quality, efficacy and safety. Area covered: This article collects and summarises data of all the stability studies of repackaged medicines into DAAs, as the result of a computerized search in databases (PubMed, Google Scholar, SciELO, and reference texts related to the field...
May 24, 2018: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/29790466/association-of-anger-expression-out-with-nk-cell-counts-in-colorectal-cancer-patients
#2
Estela Kakoo-Brioso, Luís Costa, Sílvia Ouakinin
INTRODUCTION: There is growing evidence describing the relation between psychological factors and the progression of colorectal cancer. Several mechanisms have been proposed but the one showing more promising evidence relies on the modulation of the antitumoral immune response by psychological factors, particularly through natural killer cells. We aimed to study the relation between natural killer cell count and anxiety, depression and anger state, trait and expression in 54 pre-surgical colorectal cancer patients...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29788093/reply-to-buonfrate-and-bisoffi
#3
Silvia A Repetto, Paula Ruybal, Estela Batalla, Carlota López, Vanesa Fridman, Mariela Sierra, Marcelo Radisic, Pablo M Bravo, Marikena G Risso, Stella M González Cappa, Catalina D Alba Soto
No abstract text is available yet for this article.
May 17, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29787679/dynamic-proteome-alteration-and-functional-modulation-of-human-saliva-induced-by-dietary-chemosensory-stimuli
#4
Matthias Bader, Andreas Dunkel, Mareike Wenning, Bernd Kohler, Guillaume Medard, Estela Del Castillo, Amin Gholami, Bernhard Kuster, Siegfried Scherer, Thomas Hofmann
Saliva flow measurements and SDS-PAGE separation of human whole saliva freshly collected after oral stimulation with citric acid (sour), aspartame (sweet), iso-α-acids (bitter), mono sodium L-glutamate (umami), NaCl (salty), 6-gingerol (pungent), hydroxy-α-sanshool (tingling), and hydroxy-β-sanshool (numbing), followed by tryptic digestion, nano-HPLC-MS/MS, and label-free protein quantitation demonstrated a stimulus- and time-dependent influence of the dietary chemosensates on salivation and the salivary proteome composition...
May 22, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29779410/personalized-charts-for-the-fetal-corpus-callosum-length
#5
Abraham Tsur, Boaz Weisz, Orgad Rosenblat, Daniel Shai, Estela Derazne, David K Stevenson, Reuven Achiron, Eldad Katorza
OBJECTIVE: To personally customize the antenatal ultrasound charts for the fetal corpus callosum (CC) length. METHODS: A retrospective analysis of fetal neuro-sonography scans. Cases were grouped as normal neuro-sonographic evaluation (normal) or as high risk and suspected brain anomaly (abnormal). The normal group was subcategorized according to Cignini's CC length charts. Data of fetuses with a CC length between the 5th-95th percentile served for creating new charts, describing the ratio of the CC length to the major biometric parameters as a function of gestational age (GA)...
May 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29762330/management-of-severe-cicatricial-entropion-with-labial-mucous-membrane-graft-in-cicatricial-ocular-surface-disorders
#6
Tammy H Osaki, Ana Estela Sant'Anna, Midori H Osaki, Don O Kikkawa, Cristina Yabumoto, Patrick Yang, Bobby S Korn
The management of cicatricial entropion represents a therapeutic challenge especially when the underlying causes are progressive cicatricial diseases that affect the ocular surface. The authors aimed to report long-term efficacy of labial mucous membrane graft to manage severe cicatricial entropion of the upper eyelid. This study is a retrospective chart review of patients who underwent tarsotomy associated with labial mucous membrane graft to treat severe cicatricial entropion of the upper eyelid. Surgeries were performed over a 16-year period...
May 14, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29755555/the-ethanolic-extract-of-eysenhardtia-polystachya-ort-sarg-bark-and-its-fractions-delay-the-progression-of-rheumatoid-arthritis-and-show-antinociceptive-activity-in-murine-models
#7
Saudy Saret Pablo-Pérez, Benjamín Parada-Cruz, Olivier Christophe Barbier, María Estela Meléndez-Camargo
Eysenhardtia polystachya is widely used in folk medicine as an anti-rheumatic and analgesic agent, but no systematic study of its effects on several markers associated with rheumatoid arthritis and its ethnomedical use as analgesic agent has been performed. We evaluated the anti-arthritic and antinociceptive properties of an ethanolic extract of E. polystachya (EE) bark and its rich-flavonoids fractions in murine models. The EE was administered orally at doses of 25, 50, 100, and 200 mg/kg/day, and its fractions at 25 mg/kg/day in all animal models...
2018: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/29749297/health-behavior-related-indicator-of-lifestyle-application-in-the-elsa-brasil-study
#8
Ana Luísa Patrão, Maria-da-Conceição C Almeida, Sheila Alvim, Dora Chor, Estela M L Aquino
Various behaviors are considered health enhancing. Nevertheless, according to the current scientific literature, four health behaviors are considered particularly risky in view of their association with a group of chronic diseases: 1) smoking; 2) excessive alcohol consumption; 3) poor diet; and 4) lack of physical activity. Theoretically, it should be possible to make improvements to one's health by maximizing the number of healthy behaviors and minimizing the unhealthy ones. However, in reality, the different behaviors interconnect to create more complex lifestyles...
May 1, 2018: Global Health Promotion
https://www.readbyqxmd.com/read/29748247/reduced-levels-of-stromal-sex-hormone-binding-globulin-and-androgen-receptor-dysfunction-in-the-sperm-storage-region-of-the-rat-epididymis
#9
Fabiane de Santi, Flávia L Beltrame, Barry T Hinton, Paulo S Cerri, Estela Sasso-Cerri
The cauda epididymidis is the major sperm storage region whose androgenic supply, essential for the sperm viability, is provided by the vasculature and is dependent upon testosterone diffusion through the stromal tissue to reach the epithelial cells. We have focused our efforts on examining the regulation of this important epididymal region by evaluating the impact of the androgen disrupter cimetidine on the epithelial-stromal androgenic microenvironment. Male rats received 100 mg/kg cimetidine (CMTG) or saline (CG) for 50 days, serum testosterone levels were measured and the epididymal cauda region was processed for light and transmission electron microscopy...
June 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29735085/evaluating-the-effects-of-the-adulterants-in-milk-using-direct-infusion-high-resolution-mass-spectrometry
#10
Tatiane Melina Guerreiro, Diogo Noin de Oliveira, Carlos Fernando Odir Rodrigues Melo, Estela de Oliveira Lima, Marta da Silva Ribeiro, Rodrigo Ramos Catharino
Milk is an extremely complex food, capable of providing essential nutrients as well as being an important source of energy, and high-quality proteins and fats. Due to advances in technology, and to meet the increasing demand, production costs have increased, turning milk into a target of adulterations. Routine methods usually applied to certify the quality of the milk are restricted to microbiological tests, and assays that attest the nutritional composition within the expected values. However, potentially harmful byproducts generated by adulterating substances in general are not detected through these methodologies...
June 2018: Food Research International
https://www.readbyqxmd.com/read/29732527/electrical-isolation-of-the-superior-vena-cava-by-laser-balloon-ablation-in-patients-with-atrial-fibrillation
#11
Martín R Arceluz, Pedro F Cruz, Estela Falconi, Rosa Montes de Oca, Reina Delgado, Jorge Figueroa, Marta Ortega, José L Merino
PURPOSE: The aim of the present study is to evaluate the feasibility and safety of SVC electrical isolation by LB ablation in patients with atrial fibrillation (AF) referred for pulmonary vein isolation (PVI). METHODS: Electrical disconnection of the SVC was attempted by LB in 13 consecutive patients (59 ± 10.5 years, 11 male) with AF following PVI. PVI was successfully achieved by standard LB in all before attempting SVC isolation. RESULTS: A laser beam was delivered with 6...
May 7, 2018: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://www.readbyqxmd.com/read/29731654/synergistic-effects-of-combined-therapy-nonfocused-ultrasound-plus-aussie-current-for-noninvasive-body-contouring
#12
Vivianne Carvalho Canela, Cinthia Nicoletti Crivelaro, Luciane Zacchi Ferla, Gisele Marques Pelozo, Juliana Azevedo, Richard Eloin Liebano, Caroline Nogueira, Renata Michelini Guidi, Clóvis Grecco, Estela Sant'Ana
Background and objectives: Nowadays, there are several noninvasive technologies being used for improving of body contouring. The objectives of this pilot study were to verify the effectiveness of the Heccus® device, emphasizing the synergism between nonfocused ultrasound plus Aussie current in the improvement of body contour, and to determine if the association of this therapy with whole-body vibration exercises can have additional positive effects in the results of the treatments. Subjects and methods: Twenty healthy women aged 20-40 years participated in the study...
2018: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/29729942/performance-of-the-asthma-impact-on-quality-of-life-scale-a-iqols-in-diverse-asthma-research-populations-and-demographic-sub-groups
#13
Sandra R Wilson, Robert A Wise, Mario Castro, Michael J Mulligan, Estela Ayala, Alan Chausow, Qiwen Huang, Santosh Gummidipundi
BACKGROUND: The Asthma Impact on Quality of Life Scale (A-IQOLS) assesses patient-perceived negative effect of asthma on quality of life (QoL). Its standard error of measurement is known, it has strong construct, convergent, and divergent validity, and provides information that is unique among asthma outcome measures. OBJECTIVE: To characterize A-IQOLS' psychometric properties and suitability for use in demographically and clinically diverse adult asthma populations...
May 3, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29729241/acute-epigastric-pain-as-the-cause-of-urgent-gastrectomy-in-a-healthy-patient-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2-%C3%A2
#14
Soria López Estela, Villar Puertas Ana, Sánchez Rodríguez Yolanda María, Granados Pacheco Francisco, Rosales Zábal José Miguel, Fernández Gutiérrez Del Álamo Fátima, Pereda Salguero Teresa, Martín Carvajal Francisco, Bercedo Martínez Julio
No abstract text is available yet for this article.
May 2, 2018: American Journal of Medicine
https://www.readbyqxmd.com/read/29727867/coronal-knee-malalignment-in-young-adults-and-its-link-to-body-measures
#15
Oded Hershkovich, Ran Thein, Barak Gordon, Gideon Burstein, Shay Tenenbaum, Estela Derazne, Dorit Tzur, Arnon Afek
Our aim was to report the prevalence of knee varus-valgus malalignment (KVVM) and its association with body mass index (BMI) and body height in a healthy and fit young adult population. Information on the disability codes associated with KVVM according to the Regulations of Medical Fitness Determination was retrieved from a medical database containing records of 17-year-old males and females before their recruitment into mandatory military service. Logistic regression models assessed the association between the BMI and body height to KVVM...
May 4, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29727806/neoplasms-associated-deaths-in-hiv-1-infected-and-non-infected-patients-in-bahia-brazil
#16
Marinho Marques, Estela Luz, Mateus Leal, João Vitor Oliveira, Rejane Patrício, Eduardo Martins Netto, Carlos Brites
BACKGROUND: HIV-infected patients are at a higher risk to develop malignancies than general population. Although AIDS-related malignancies are a common feature of late-stage disease, patients under successful antiretroviral therapy also have an increased risk for development of non-AIDS malignancies. OBJECTIVE: To compare the frequency and characteristics of adults HIV-infected patients and general population who died of malignancies in Bahia, Brazil from January 2000 to December 2010...
May 1, 2018: Cancer Epidemiology
https://www.readbyqxmd.com/read/29727487/kinetics-of-torque-teno-virus-dna-load-in-saliva-and-plasma-following-allogeneic-hematopoietic-stem-cell-transplantation
#17
Eliseo Albert, Ignacio Torres, Alberto Talaya, Estela Giménez, José Luis Piñana, Juan Carlos Hernández-Boluda, Daniele Focosi, Lisa Macera, Fabrizio Maggi, Carlos Solano, David Navarro
Plasma Torque Teno virus (TTV) DNA load directly correlates with the degree of T-cell immune reconstitution early after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Here, the kinetics of oral TTV DNA shedding was examined to assess whether quantitation of TTV DNA load in saliva may either replace or complement that in plasma for predicting lymphocyte (ALC) reconstitution following engraftment. This prospective observational study enrolled 38 non-consecutive allo-HSCT recipients. Saliva and plasma specimens were collected at baseline (pre-transplant) and at around days +30, +50 and +90 after allo-HSCT...
May 4, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29727250/assessing-the-influence-of-visitors-sociodemographic-and-trip-characteristics-on-physical-activity-intensities-in-alt-pirineu-natural-park-spain
#18
Estela Farías-Torbidoni, Demir Barić, Sebastià Mas-Alòs
BACKGROUND: Protected natural areas provide a promising opportunity for improving healthy life habits through engagement in a variety of physical activities (PAs). As visitors to protected natural areas do not behave as a homogenous group, it is necessary to better understand the association between their characteristics and the level of activities engaged in. Using Alt Pirineu Natural Park (Spain) as a case study, the purpose of this work is to examine the influence of visitors' sociodemographic and trip characteristics on the likelihood of the visitors engaging in distinct PA intensities...
May 4, 2018: Journal of Physical Activity & Health
https://www.readbyqxmd.com/read/29724268/validation-of-a-plasma-metabolomics-model-that-allows-anticipation-of-the-occurrence-of-cytomegalovirus-dnaaemia-in-allogeneic-stem-cell-transplant-recipients
#19
Daniel Monleón, Alberto Talaya, Estela Giménez, Víctor Vinuesa, José Manuel Morales, Juan Carlos Hernández-Boluda, Ariadna Pérez, José Luis Piñana, Carlos Solano, David Navarro
A plasma metabolomic model obtained by means of untargeted 1 H nuclear magnetic resonance, to which taurine, choline, methylamine, total glutathione, trimethylamine N-oxide, lactate, lysine, isoleucine, total fatty acids and unsaturated fatty acids contributed, was validated for the prediction of first episodes of cytomegalovirus (CMV) DNAaemia in a cohort of 79 allogeneic stem haematopoietic stem cell transplant (allo-HSCT) recipients. The predictive success rate was nearly 65 % for patients at both low and high risk of CMV-related complications according to their baseline characteristics...
May 4, 2018: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29720336/hypothyroidism-affects-lipid-and-glycogen-content-and-peroxisome-proliferator-activated-receptor-expression-in-the-ovary-of-the-rabbit
#20
Julia Rodríguez-Castelán, Maribel Méndez-Tepepa, Jorge Rodríguez-Antolín, Francisco Castelán, Estela Cuevas-Romero
Dyslipidaemia and hyperglycaemia are associated with ovarian failure and both have been related to hypothyroidism. Hypothyroidism promotes anovulation and ovarian cysts in women and reduces the size of follicles and the expression of aromatase in the ovary of rabbits. Considering that ovarian steroidogenesis and ovulation depend on lipid metabolism and signalling, the aim of the present study was to analyse the effect of hypothyroidism on the lipid content and expression of peroxisome proliferator-activated receptor (PPAR) δ in the ovary...
May 3, 2018: Reproduction, Fertility, and Development
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