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https://www.readbyqxmd.com/read/29669464/adiponectin-and-chemerin-contrary-adipokines-in-regulating-reproduction-and-metabolic-disorders
#1
Anusha Singh, Mayank Choubey, Puran Bora, Amitabh Krishna
Metabolic disorders such as obesity and type 2 diabetes are one of the most familiar risk factors in the present time among every age-group. It is associated with altered levels of adipokines such as adiponectin, chemerin, leptin, resistin, visfatin, and so on. Adiponectin is one of the adipocyte-specific protein with novel applications pertaining to metabolism by promoting insulin sensitivity and regulating glucose and fatty acid catabolism, while chemerin is considered as an inhibitor of insulin signaling and glucose catabolism...
January 1, 2018: Reproductive Sciences
https://www.readbyqxmd.com/read/29662629/pre-diagnostic-biomarkers-of-metabolic-dysregulation-and-cancer-mortality
#2
Tomi Akinyemiju, Justin Xavier Moore, Suzanne E Judd, Maria Pisu, Michael Goodman, Virginia J Howard, Leann Long, Monika Safford, Susan C Gilchrist, Mary Cushman
INTRODUCTION: The obesogenic milieu is a pro-tumorigenic environment that promotes tumor initiation, angiogenesis and metastasis. In this prospective cohort, we examined the association between pre-diagnostic metabolic biomarkers, plasma adiponectin, resistin, leptin and lipoprotein (a), and the risk of cancer mortality. METHODS: Prospective data was obtained from the REasons for Geographic and Racial Differences in Stroke (REGARDS) cohort of Blacks and Whites followed from 2003 through 2012 for cancer mortality...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29655569/activation-of-the-porcine-alveolar-macrophages-via-toll-like-receptor-4-nf-%C3%AE%C2%BAb-mediated-pathway-provides-a-mechanism-of-resistin-leading-to-inflammation
#3
Bi Li, Jing Fang, Zhicai Zuo, Sirui Yin, Tingting He, Mingxian Yang, Junliang Deng, Liuhong Shen, Xiaoping Ma, Shumin Yu, Ya Wang, Zhihua Ren, Hengmin Cui
Resistin, a previously discovered cysteine-rich adipokine known to regulate glucose metabolism, has been emerged as a mediator in inflammation and immunity. Its level was supposed to be related to the expression of indicators, such as interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) in inflammation. Toll-like receptor 4 (TLR4) was reported to be a receptor for resistin in cells, like leukocytes and peripheral blood mononuclear cells (PBMC). However, the pro-inflammatory role of resistin and its intracellular mechanisms in alveolar macrophages have not been thoroughly validated...
April 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29649030/resistin-is-a-novel-marker-for-postoperative-pain-intensity
#4
Jun Hozumi, Masahiko Sumitani, Daisuke Nishizawa, Makoto Nagashima, Kazutaka Ikeda, Hiroaki Abe, Ryoji Kato, Yoshiomi Kusakabe, Yoshitsugu Yamada
BACKGROUND: Pro- and anti-inflammatory cytokines (adipokines) associated with adipose tissue can modulate inflammatory processes and lead to systemic inflammatory conditions such as metabolic syndrome. In the present pilot study, we investigated 3 major adipokines (leptin, adiponectin, and resistin) and 2 nonspecific proinflammatory cytokines (tumor necrosis factor α and interleukin-6) with regard to their association with postoperative pain intensity. METHODS: We analyzed a total of 45 single-nucleotide polymorphisms of the adipokines in 57 patients with postlaparotomy pain...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29626829/the-effects-of-adiposity-and-alcohol-use-disorder-on-adipokines-and-biomarkers-of-inflammation-in-depressed-patients
#5
Mari Archer, Onni Niemelä, Mari Hämäläinen, Eeva Moilanen, Esa Leinonen, Olli Kampman
Patients with depression and alcohol use disorder frequently present with elevated markers of inflammation. Adipose tissue may function as a source for inflammation, yet the interplay between adiposity, alcohol use and depression has remained unknown. We examined 242 patients, referred to treatment for depressive symptoms, and followed for a period of 6 months. The assessments included screening for alcohol use and measurements of body mass index, serum adiponectin, leptin, resistin, progranulin, hs-CRP, IL-6 and MCP-1 at baseline and after 6 months of treatment...
March 28, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29615544/is-there-a-relationship-between-resistin-levels-and-left-ventricular-end-diastolic-pressure
#6
Özge Turgay Yıldırım, Aylin Yıldırır, Leyla Elif Sade, Senem Has Hasırcı, Hatice Kozan, Emre Özçalık, Kaan Okyay, Uğur Abbas Bal, Alp Aydınalp, Haldun Müderrisoğlu
OBJECTIVE: Resistin, a cysteine-rich peptide, is associated with atherosclerosis and diabetes. Resistin levels increase corresponding to coronary artery disease (CAD) and heart failure severity. Since resistin level tends to elevate with symptomatic heart failure, it is expected to be associated with left ventricular end-diastolic pressure (LVEDP). However, there is no relevant literature on the relationship between resistin levels and LVEDP. We aimed to evaluate the association between resistin levels and LVEDP, severity of CAD, carotid intima-media thickness (CIMT), and echocardiographic diastolic dysfunction parameters...
April 2018: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/29614883/bergamottin-inhibits-adipogenesis-in-3t3-l1-cells-and-weight-regulation-in-diet-induced-obese-mice
#7
Jeong-Hyeon Ko, Dongwoo Nam, Jae-Young Um, Sang Hoon Jung, Kwang Seok Ahn
Obesity is a serious and increasing health problem worldwide, and the inhibition of adipogenesis is considered to be a potential therapeutic target for it. Bergamottin (BGM), a component of grapefruit juice, has been reported to regulate lipolysis. However, the physiological role of BGM in obesity has not been evaluated so far. In the present study, we investigated the effects of BGM on obesity in 3T3-L1 cells and in mice fed a high-fat diet (HFD). BGM inhibited adipogenic differentiation of 3T3-L1 cells along with a significant decrease in the lipid content by downregulating the expression of two critical adipogenic factors, CCAAT enhancer-binding protein-alpha (C/EBP[Formula: see text]) and peroxisome proliferator activated receptor-gamma (PPAR[Formula: see text])...
April 4, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29607306/resistin-levels-in-non-alcoholic-fatty-liver-disease-pathogenesis
#8
Carmela Colica, Ludovico Abenavoli
No abstract text is available yet for this article.
March 2018: Journal of Translational Internal Medicine
https://www.readbyqxmd.com/read/29605824/utility-of-serum-resistin-in-the-diagnosis-of-neonatal-sepsis-and-prediction-of-disease-severity-in-term-and-late-preterm-infants
#9
Ahmed Anwar Khattab, Muhammad Said El-Mekkawy, Mohamed Ahmed Helwa, Ehab Seif Omar
INTRODUCTION: Resistin is a proinflammatory hormone recently proposed as a sepsis biomarker. Our aim was to evaluate the diagnostic and prognostic values of this marker in neonatal sepsis. METHODS: This is a prospective observational study that includes 60 term and late preterm neonates with proven and possible sepsis besides 30 healthy controls. Resistin and other biomarkers, like C-reactive protein (CRP), were measured within 2 h of neonatal intensive care unit (NICU) admission...
March 31, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29604272/resistin-upregulates-muc5ac-b-mucin-gene-expression-in-human-airway-epithelial-cells
#10
Soyoung Kwak, Yong-Dae Kim, Hyung Gyun Na, Chang Hoon Bae, Si-Youn Song, Yoon Seok Choi
Adipokines, a group of proteins including leptin, visfatin, resistin, and adiponectin, are produced by adipocytes. Among adipokines, resistin is implicated in insulin resistance and inflammatory response modulation. Mucus hypersecretion has been greatly linked to airway diseases, such as asthma, chronic obstructive pulmonary disease, and rhinosinusitis. Increasing evidence has indicated that adipokines, such as leptin and visfatin, play important regulatory roles in various biological processes involved in mucus secretion...
March 28, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29599686/alignments-of-endocrine-anthropometric-and-metabolic-parameters-in-type-2-diabetes-after-intervention-with-an-okinawa-based-nordic-diet
#11
Bodil Ohlsson, Gassan Darwiche, Bodil Roth, Peter Höglund
Background: An Okinawa-based Nordic diet with moderately low carbohydrate content and high fat and protein content has been shown to improve anthropometry and metabolism in type 2 diabetes. Objective: The objectives of this study were to measure plasma or serum levels of hormones regulating energy metabolism and metabolic control, that is, cholecystokinin (CCK), Cortisol, C-peptide, ghrelin, glucagon, glucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic polypeptide (GIP), insulin, leptin, plasminogen activator inhibitor-1 (PAI-1), polypeptide YY (PYY), resistin, and visfatin after this diet intervention, and to determine partial correlations between hormonal levels and anthropometric and metabolic responses...
2018: Food & Nutrition Research
https://www.readbyqxmd.com/read/29590229/association-of-oxytocin-with-glucose-intolerance-and-inflammation-biomarkers-in-metabolic-syndrome-patients-with-and-without-prediabetes
#12
Amal Akour, Violet Kasabri, Nailya Bulatova, Suha Al Muhaissen, Randa Naffa, Hiba Fahmawi, Munther Momani, Ayman Zayed, Yasser Bustanji
OBJECTIVES: The aim of this study was to explore the differences in OXT levels in metabolic syndrome (MetS) subjects, newly diagnosed type 2 diabetes mellitus (T2D), and prediabetes subjects vs. MetS subjects without glucose intolerance (non-diabetic MetS). It was also intended to determine the relationship between plasma OXT levels and inflammatory markers in those subjects. METHODS: Along with 45 lean and normoglycemic controls, a total of 190 MetS subjects (61 men, 129 women) were enrolled...
2018: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29589625/long-chain-polyunsaturated-fatty-acids-and-extensively-hydrolyzed-casein-induced-browning-in-a-ucp-1-reporter-mouse-model-of-obesity
#13
Liufeng Mao, Jiwen Lei, Marieke H Schoemaker, Bingxiu Ma, Yan Zhong, Tim T Lambers, Eric A F Van Tol, Yulai Zhou, Tao Nie, Donghai Wu
Browning in adipose tissues, which can be affected by diet, may mitigate the detrimental effects of adiposity and improve longer-term metabolic health. Here, browning-inducing effects of long-chain polyunsaturated fatty acids, e.g., arachidonic acid (ARA)/docosahexaenoic acid (DHA) and extensively hydrolyzed casein (eHC) were investigated in uncoupling protein 1 (Ucp-1) reporter mice. To address the overall functionality, their potential role in supporting a healthy metabolic profile under obesogenic dietary challenges later in life was evaluated...
March 28, 2018: Food & Function
https://www.readbyqxmd.com/read/29589386/association-of-adipokines-with-development-and-progression-of-nonalcoholic-fatty-liver-disease
#14
REVIEW
Chrysoula Boutari, Nikolaos Perakakis, Christos Socrates Mantzoros
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease affecting 30% of the general population and 40% to 70% of obese individuals. Adipose tissue plays a crucial role in its pathogenesis, as it produces and secretes pro- and anti-inflammatory cytokines called adipokines. Adiponectin and leptin have well-determined actions in terms of NAFLD pathophysiology. Adiponectin deficiency is associated with a pro-inflammatory condition, as it is observed in obesity and other metabolic disorders. On the other hand, increased leptin levels, above the normal levels, act as a pro-inflammatory stimulus...
March 2018: Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29587377/groundsel-bush-baccharis-halimifolia-extract-promotes-adipocyte-differentiation-in-vitro-and-increases-adiponectin-expression-in-mature-adipocytes
#15
Anik Boudreau, Scott Fuller, David M Ribnicky, Allison J Richard, Jacqueline M Stephens
An ethanolic extract of Baccharis halimifolia (groundsel bush, GB), which is a native Louisiana plant with documented use in Creole folk medicine, has been shown to inhibit lipopolysaccharide (LPS)-induced inflammation in cultured macrophages. Here, we examine the effects of GB on adipocyte development and function, as these processes are attractive targets for intervention in insulin resistance. Oil Red O neutral lipid staining, reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and immunoblotting were used to measure GB effects on lipid accumulation, gene expression, and protein abundance, respectively...
March 25, 2018: Biology
https://www.readbyqxmd.com/read/29584687/association-between-resistin-gene-polymorphisms-and-atopic-dermatitis
#16
Saleem A Banihani, Khawla F Abu-Alia, Omar F Khabour, Karem H Alzoubi
Atopic dermatitis (AD) is a chronic, relapsing, and inflammatory skin disorder. It is characterized by an inappropriate skin barrier function, allergen sensitization, and recurrent skin infections. Resistin is an adipokine expressed mainly in macrophages and monocytes; it has a role in the inflammatory process and is associated with multiple inflammatory human diseases; however, only few studies linked resistin to atopic dermatitis. This study tested the association between G>A (rs3745367) and C>T (rs3219177) single nucleotide polymorphisms (SNPs) of the RETN gene with atopic dermatitis...
March 27, 2018: Biomolecules
https://www.readbyqxmd.com/read/29571590/cardiovascular-risk-biomarkers-and-metabolically-unhealthy-status-in-prepubertal-children-comparison-of-definitions
#17
A I Rupérez, J Olza, M Gil-Campos, R Leis, G Bueno, C M Aguilera, A Gil, L A Moreno
BACKGROUND AND AIMS: The early onset of cardio-metabolic abnormalities, known as metabolically unhealthy (MU) status, is highly associated with obesity and cardiovascular disease (CVD), as well as with increased morbidity and mortality later in life. Given the lack of a consensus MU classification for prepubertal children, we aimed to compare available MU definitions in terms of their association with CVD risk biomarkers. METHODS AND RESULTS: A total of 930 prepubertal children (622 with overweight/obesity, 462 males) aged 5-10...
February 16, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29568521/elevated-circulatory-levels-of-leptin-and-resistin-impair-therapeutic-efficacy-of-dacarbazine-in-melanoma-under-obese-state
#18
Parmanand Malvi, Balkrishna Chaube, Shivendra Vikram Singh, Naoshad Mohammad, Maleppillil Vavachan Vijayakumar, Snahlata Singh, Surbhi Chouhan, Manoj Kumar Bhat
Background: Obesity is associated with increased risk, poor prognosis and outcome of therapy, in various cancers. Obesity-associated factors or adipokines, especially leptin and resistin, are purported to promote growth, survival, proliferation, and invasiveness of cancer cells. However, the mechanistic link between these adipokines and therapeutic response in malignancies is not clearly understood. Methods: ob/ob and db/db mouse models were used in this study to evaluate the role of leptin and resistin towards the outcome of dacarbazine (DTIC) therapy in melanoma...
2018: Cancer & Metabolism
https://www.readbyqxmd.com/read/29566726/increased-circulating-resistin-levels-in-early-onset-breast-cancer-patients-of-normal-body-mass-index-correlate-with-lymph-node-negative-involvement-and-longer-disease-free-survival-a-multi-center-posh-cohort-serum-proteomics-study
#19
Bashar Zeidan, Antigoni Manousopoulou, Diana J Garay-Baquero, Cory H White, Samantha E T Larkin, Kathleen N Potter, Theodoros I Roumeliotis, Evangelia K Papachristou, Ellen Copson, Ramsey I Cutress, Stephen A Beers, Diana Eccles, Paul A Townsend, Spiros D Garbis
BACKGROUND: Early-onset breast cancer (EOBC) affects about one in 300 women aged 40 years or younger and is associated with worse outcomes than later onset breast cancer. This study explored novel serum proteins as surrogate markers of prognosis in patients with EOBC. METHODS: Serum samples from EOBC patients (stages 1-3) were analysed using agnostic high-precision quantitative proteomics. Patients received anthracycline-based chemotherapy. The discovery cohort (n = 399) either had more than 5-year disease-free survival (DFS) (good outcome group, n = 203) or DFS of less than 2 years (poor outcome group, n = 196)...
March 22, 2018: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29561430/resistin-polymorphisms-are-associated-with-rheumatoid-arthritis-susceptibility-in-chinese-han-subjects
#20
Lihong Wang, Chih-Hsin Tang, Tingting Lu, Yi Sun, Guohong Xu, Chien-Chung Huang, Shun-Fa Yang, Chen-Ming Su
Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease. To date, the specific mechanisms that drive RA disease remain unknown and provide the impetus for genetic investigations into the development of RA. Researchers hope to identify gene polymorphisms that could serve as treatment targets in patients with RA. We have previously suggested that the gene encoding the pro-inflammatory adipokine resistin (RETN) may correlate with RA development. In this report, we sought to determine whether selected RETN single nucleotide polymorphisms (SNPs) are associated with RA susceptibility and clinicopathological characteristics...
March 2018: Medicine (Baltimore)
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