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https://www.readbyqxmd.com/read/27907172/neuroendocrine-inflammatory-responses-in-overweight-obese-infants
#1
Ana Cristina Resende Camargos, Vanessa Amaral Mendonça, Camila Alves de Andrade, Katherine Simone Caires Oliveira, Rosalina Tossige-Gomes, Etel Rocha-Vieira, Camila Danielle Cunha Neves, Érica Leandro Marciano Vieira, Hércules Ribeiro Leite, Murilo Xavier Oliveira, Antônio Lúcio Teixeira Júnior, Cândido Celso Coimbra, Ana Cristina Rodrigues Lacerda
Childhood obesity is related to a cascade of neuroendocrine inflammatory changes. However, there remains a gap in the current literature regarding the possible occurrence of these changes in overweight/obese infants. The objective of this study was to evaluate adipokines, cortisol, brain-derived neurotrophic factor (BDNF) and redox status in overweight/obese infants versus normal-weight peers. A cross-sectional study was conducted with 50 infants (25 in the overweight/obese group and 25 in the normal-weight group) between 6 and 24 months...
2016: PloS One
https://www.readbyqxmd.com/read/27902927/antidiabetic-activity-of-ganoderma-lucidum-polysaccharides-f31-down-regulated-hepatic-glucose-regulatory-enzymes-in-diabetic-mice
#2
Chun Xiao, Qingping Wu, Jumei Zhang, Yizhen Xie, Wen Cai, Jianbin Tan
ETHNOPHARMACOLOGICAL RELEVANCE: Ganoderma lucidum (Lin Zhi) has been used to treat diabetes in Chinese folk for centuries. Our laboratory previously demonstrated that Ganoderma lucidum polysaccharides (GLPs) had hypoglycemic effects in diabetic mice. Our aim was to identify the main bioactives in GLPs and corresponding mechanism of action. MATERIALS AND METHODS: Four polysaccharide-enriched fraction were isolated from GLPs and the antidiabetic activities were evaluated by type 2 diabetic mice...
November 27, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27901337/the-effect-of-exercise-induced-weight-loss-on-myokines-and-adipokines-in-overweight-sedentary-females-steps-aerobics-vs-jogging-walking-exercises
#3
Halil Duzova, Esin Gullu, Guner Cicek, Burcu K Koksal, Basak Kayhan, Abdullah Gullu, Ibrahim Sahin
BACKGROUND: The objectives of this study were to verify effects of step-aerobic exercise (SAE) and jogging-walking exercise (JWE) program on myokines and adipokines levels in overweight sedentary females. METHODS: Volunteer subjects (n=25) were assigned to two exercise groups: steps aerobics and jogging-walking. The exercise program given to them was for five days a week and for twelve weeks period. Serum samples were collected from venous blood before and immediately after cardio-respiratory fitness test (CRF) by Bruce protocol and stored at -80 C until they were assayed before 12 weeks exercise program...
November 30, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27886976/airway-and-serum-adipokines-after-allergen-and-diesel-exposure-in-a-controlled-human-crossover-study-of-atopic-adults
#4
Marabeth M Kramer, Jeremy A Hirota, Akshay Sood, Kay Teschke, Christopher Carlsten
Adipokines are mediators released from adipose tissue. These proteins are regarded as active elements of systemic and pulmonary inflammation, whose dysregulation can alter an individual's risk of developing allergic lung diseases. Despite this knowledge, adipokine responses to inhaled stimuli are poorly understood. We sought to measure serum and lung adiponectin, leptin, and resistin in an atopic adult study population following exposure to allergen and diesel exhaust (DE). Two types of lung samples including bronchoalveolar lavage (BAL) and bronchial wash (BW), and a time course of serum samples, were collected from the 18 subjects who participated in the randomized, double-blinded controlled human study...
November 9, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27884778/expression-of-adipokines-in-osteoarthritis-osteophytes-and-their-effect-on-osteoblasts
#5
Susann Junker, Klaus W Frommer, Grit Krumbholz, Lali Tsiklauri, Rüdiger Gerstberger, Stefan Rehart, Jürgen Steinmeyer, Markus Rickert, Sabine Wenisch, Georg Schett, Ulf Müller-Ladner, Elena Neumann
OBJECTIVE: Osteophyte formation in osteoarthritis (OA) is mediated by increased osteoblast activity, which is -in turn- regulated by the Wnt signaling pathway. Obesity is regarded a risk factor in OA, yet little is known about the interaction between adipose tissue-derived factors, the adipokines, and bone formation, although adipokines are associated with the pathogenesis of OA. Therefore, the effect of adipokines on bone and cartilage forming cells and osteophyte development was analyzed...
November 21, 2016: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/27877903/the-novel-functional-nucleic-acid-ired-effectively-regulates-target-genes-following-cytoplasmic-delivery-by-faint-electric-treatment
#6
Mahadi Hasan, Noriko Tarashima, Koki Fujikawa, Takashi Ohgita, Susumu Hama, Tamotsu Tanaka, Hiroyuki Saito, Noriaki Minakawa, Kentaro Kogure
An intelligent shRNA expression device (iRed) contains the minimum essential components needed for shRNA production in cells, and could be a novel tool to regulate target genes. However, general delivery carriers consisting of cationic polymers/lipids could impede function of a newly generated shRNA via electrostatic interaction in the cytoplasm. Recently, we found that faint electric treatment (fET) of cells enhanced delivery of siRNA and functional nucleic acids into the cytoplasm in the absence of delivery carriers...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27860068/effect-of-osa-on-hypoxic-and-inflammatory-markers-during-cpap-withdrawal-further-evidence-from-three-randomized-control-trials
#7
Chris D Turnbull, Valentina A Rossi, Peter Santer, Esther I Schwarz, John R Stradling, Nayia Petousi, Malcolm Kohler
BACKGROUND AND OBJECTIVE: Obstructive sleep apnoea (OSA) is associated with cardiovascular disease. Intermittent hypoxia, endothelial dysfunction and adipose tissue-mediated inflammation have all been linked to cardiovascular disease in OSA. We therefore explored the effect of OSA on relevant associated blood markers: adrenomedullin (ADM), endocan, endothelin-1 (ET-1), resistin and vascular endothelial growth factor (VEGF). METHODS: Patients with OSA, established on and compliant with continuous positive airways pressure (CPAP) therapy for >1 year were included from three randomized controlled trials, conducted at two centres...
November 18, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/27856635/micrornaa-155-deficiency-leads-to-decreased-atherosclerosis-increased-white-adipose-tissue-obesity-and-nonalcoholic-fatty-liver-disease-a-novel-mouse-model-of-obesity-paradox
#8
Anthony Virtue, Candice Johnson, Jahaira Lopez-Pastraña, Ying Shao, Hangfei Fu, Xinyuan Li, Ya-Feng Li, Ying Yin, Jietang Mai, Victor Rizzo, Michael Tordoff, Zsolt Bagi, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiao-Feng Yang
Obesity paradox (OP) describes a widely observed clinical finding of improved cardiovascular fitness and survival in some overweight or obese patients. The molecular mechanisms underlying OP remain enigmatic partly due to a lack of animal models mirroring OP in patients. Using apolipoprotein E knockout (ApoE-/-) mice on high-fat (HF) diet as an atherosclerotic obesity model, we demonstrated: 1) microRNA-155 (miRNA-155, miR-155) is significantly upregulated in aortas of ApoE-/- mice; and miR-155 deficiency in ApoE-/- mice inhibits atherosclerosis; 2) ApoE-/-/miR-155-/- (DKO) mice show HF diet-induced obesity, adipocyte hypertrophy and present with nonalcoholic fatty liver disease (NAFLD); 3) DKO mice demonstrate HF diet-induced elevations of plasma leptin, resistin, fed-state and fasting insulin, increased expression of adipogenic transcription factors, but lack glucose intolerance and insulin resistance...
November 17, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27845360/pathophysiological-mechanisms-underlying-phenotypic-differences-in-pulmonary-radioresponse
#9
Isabel L Jackson, Yuji Zhang, Søren M Bentzen, Jingping Hu, Angel Zhang, Zeljko Vujaskovic
Differences in the pathogenesis of radiation-induced lung injury among murine strains offer a unique opportunity to elucidate the molecular mechanisms driving the divergence in tissue response from repair and recovery to organ failure. Here, we utilized two well-characterized murine models of radiation pneumonitis/fibrosis to compare and contrast differential gene expression in lungs 24 hours after exposure to a single dose of whole thorax lung irradiation sufficient to cause minor to major morbidity/mortality...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27844016/omentin-1-rs2274907-and-resistin-rs1862513-polymorphisms-influence-genetic-susceptibility-to-nonalcoholic-fatty-liver-disease
#10
Leila Kohan, Mehrnush Safarpur, Hamed Abdollahi
Nonalcoholic fatty liver disease (NAFLD) is an obesity-associated disease and dysregulation of adipokines has an important role in its development. Omentin-1 (ITLN1 protein) and resistin are two adipokine secreted from adipose tissue. Single nucleotide polymorphisms in the adipokine genes may affect expression and activity of the adipokine, and thus play a contributory role in NAFLD pathogenesis. The aim of the present study was to investigate the association between omentin-1 rs2274907 (326A/T) and resistin rs1862513 (-420 C/G) polymorphisms and risk of NAFLD in Iranian patients...
March 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/27833859/associations-of-25-hydroxyvitamin-d-with-markers-of-inflammation-insulin-resistance-and-obesity-in-black-and-white-community-dwelling-adults
#11
Jennifer L Jackson, Suzanne E Judd, Bhupesh Panwar, Virginia J Howard, Virginia G Wadley, Nancy S Jenny, Orlando M Gutiérrez
AIMS: Vitamin D is a fat-soluble vitamin classically known for its role in calcium absorption and bone health. Growing evidence indicates that vitamin D deficiency may be associated with inflammation, insulin resistance, and obesity. However, prior studies examining the association of vitamin D with metabolic risk factors had relatively low representation of individuals of black race, limiting their ability to characterize associations of vitamin D and parameters of metabolic health in black vs...
September 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/27825421/advances-in-the-relationship-between-adipokines-and-%C3%AE-cell-failure-in-br-type-2-diabetes-mellitus
#12
Qing Sun, Xiao-Chun Liang
β-cell failure coupled with insulin resistance plays a key role in the development of type 2 diabetes mellitus (T2DM). Changed adipokines in circulating level form a remarkable link between obesity and both β-cell failure and insulin resistance. Some adipokines have beneficial effects,whereas others have detrimental properties. The overall contribution of adipokines to β-cell failure mainly depends on the interactions among adipokines. This article reviews the role of individual adipokines such as leptin,adiponectin,and resistin in the function,proliferation,death,and failure of β-cells...
October 10, 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
https://www.readbyqxmd.com/read/27817223/discovery-of-biomarkers-for-endometrial-cancer-current-status-and-prospects
#13
Tea Lanišnik Rižner
Endometrial cancer is the most frequent gynecological malignancy in the developed world. Currently, endometrial histology is the gold standard for diagnosis, as there are no valid noninvasive diagnostic methods available. Biomarkers for endometrial cancer would be invaluable for screening of high-risk women, detection of primary and recurrent disease, and preoperative stratification of patients as high-risk and low-risk categories, enabling personalized therapeutic approaches. Areas covered: This report reviews publications of blood biomarkers evaluated in patients with endometrial cancer and/or control patients, over the last five years...
December 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27806063/biomarker-profiles-in-women-with-pcos-and-pcos-offspring-a-pilot-study
#14
Nadine M P Daan, Maria P H Koster, Marlieke A de Wilde, Gerdien W Dalmeijer, Annemieke M V Evelein, Bart C J M Fauser, Wilco de Jager
OBJECTIVE: To study metabolic/inflammatory biomarker risk profiles in women with PCOS and PCOS offspring. DESIGN: Cross-sectional comparison of serum biomarkers. SETTING: University Medical Center Utrecht. PATIENTS: Hyperandrogenic PCOS women (HA-PCOS, n = 34), normoandrogenic PCOS women (NA-PCOS, n = 34), non-PCOS reference population (n = 32), PCOS offspring (n = 14, age 6-8 years), and a paedriatic reference population (n = 30)...
2016: PloS One
https://www.readbyqxmd.com/read/27801419/-ovarian-reserve-and-adipokine-levels-in-reproductive-aged-obese-women
#15
A K Durmanova, N K Otarbaev, A Kaiyrlykyzy, K Kh Zhangazieva, Zh N Ibraeva, G B Donenbaeva, Zh T Zhusupova, A S Saidakhmetov, G Sh Temirgalieva, Zh K Salykbaeva, Zh M Tazhigulova, A M Ensebaeva, K K Seksembaeva, O K Vasilenko, S Timanova, B Akkozhina
AIM: To investigate the relationship of the ovarian reserve to the levels of adipokines and sex hormones in reproductive-aged women with abdominal obesity. SUBJECTS AND METHODS: A total of 157 women aged 18 to 45 years with a body mass index (BMI) of more than 30 kg/m2 were examined (a study group). A control group consisted of 93 women aged 18-45 years with a BMI of less than 25 kg/m2. Anthropometric and carbohydrate and lipid metabolic parameters and the levels of sex hormones, anti-Müllerian hormone, resistin, and adiponectin were investigated...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27800490/resistin-enhances-inflammatory-cytokine-production-in-coronary-artery-tissues-by-activating-the-nf-%C3%AE%C2%BAb-signaling
#16
Fang Gao, Feifei Si, Siqi Feng, Qijian Yi, Ruixi Liu
Purpose. Kawasaki disease (KD) is a systemic vasculitis and is a leading cause of coronary artery lesions (CALs) in childhood. Our previous study has shown higher levels of serum Resistin in KD patients with coronary aneurysm. This study aimed at examining the association of Resistin with inflammatory cytokine expression in mouse model of coronary arteritis and determining the potential mechanisms. Methods. C57BL/6 mice were injected with Lactobacillus cell wall extract (LCWE) to induce coronary arteritis. The relative levels of Resistin, TNF-α, IL-1β, and MMP-9 expression and inflammatory infiltrates in the coronary arteries were determined longitudinally by quantitative RT-PCR, ELISA, and histology...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27797297/resistin-is-produced-by-rat-pancreatic-islets-and-regulates-insulin-and-glucagon-in-vitro-secretion
#17
Maciej Sassek, Ewa Pruszynska-Oszmalek, Paweł A Kołodziejski, Dawid Szczepankiewicz, Przemyslaw Kaczmarek, Marianna Wieloch, Katarzyna Kurto, Leszek Nogowski, Krzysztof W Nowak, Mathias Z Strowski, Pawel Mackowiak
Resistin participates in the regulation of energy homeostasis, insulin resistance, and inflammation. The potential expression in pancreas, and modulation of the endocrine pancreas secretion by resistin is not well characterized, therefore, we examined it on several levels. We examined the localization of resistin in rat pancreatic islets by immunohistochemistry and immunofluorescence, and the potential presence of resistin mRNA by RT-PCR and protein by Western Blot in these structures. In addition, we studied the regulation of insulin and glucagon secretion by resistin in pancreatic INS-1E β- and InR-G9 α-cell lines as well as isolated rat pancreatic islets...
October 31, 2016: Islets
https://www.readbyqxmd.com/read/27795608/cytokine-profile-in-chronic-periodontitis-patients-with-and-without-obesity-a-systematic-review-and-meta-analysis
#18
REVIEW
Zohaib Akram, Tariq Abduljabbar, Mohamed Ibrahim Abu Hassan, Fawad Javed, Fahim Vohra
To investigate the cytokine profile as biomarkers in the gingival crevicular fluid (GCF) of chronic periodontitis (CP) patients with and without obesity, MEDLINE/PubMed, EMBASE, ScienceDirect, and SCOPUS databases were combined with handsearching of articles published from 1977 up to May 2016 using relevant MeSH terms. Meta-analyses were conducted separately for each of the cytokines: resistin, adiponectin, TNF-α, leptin, IL-6, IL-8, and IL-1β. Forest plots were produced reporting standardized mean difference of outcomes and 95% confidence intervals...
2016: Disease Markers
https://www.readbyqxmd.com/read/27788523/association-of-neuropeptide-y-gene-rs16147-polymorphism-with-cardiovascular-risk-factors-adipokines-and-metabolic-syndrome-in-patients-with-obesity
#19
Daniel Antonio de Luis, Olatz Izaola, Beatriz de la Fuente, David Primo, Rocio Aller
BACKGROUND AND AIMS: The NPY gene has 4 exons, and it is located at 7p15.1. The main genetic variant described in this gene is rs16147. The aim of this study was to investigate the relationship of NPY rs16147 with body weight, insulin resistance, serum adipokine levels, and risk of metabolic syndrome (MetS). METHODS: A population of 1,005 obese patients was analyzed in a cross-sectional survey. Weight, fat mass, waist circumference, blood pressure, basal glucose, C-reactive protein, insulin, insulin resistance (homeostasis model assessment of insulin resistance [HOMA-IR]), lipid profile, and adipocytokine (leptin, adiponectin, and resistin) levels were measured...
October 28, 2016: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/27780338/a-longitudinal-study-of-the-relationships-between-mood-symptoms-body-mass-index-and-serum-adipokines-in-bipolar-disorder
#20
David J Bond, Ana C Andreazza, John Hughes, Taj Dhanoa, Ivan J Torres, Jan-Marie Kozicky, L Trevor Young, Raymond W Lam, Lakshmi N Yatham
OBJECTIVE: There is a bidirectional relationship between obesity and mood disorders, with each increasing the risk of developing the other. This relationship suggests that they have overlapping pathophysiologic mechanisms. Adipose tissue-derived hormones, or adipokines, regulate appetite and metabolism and have activity in limbic brain regions, making them potential shared etiologic factors between elevated body mass index (BMI) and mood disorders. However, the precise relationships between BMI, mood, and adipokines are unknown...
October 25, 2016: Journal of Clinical Psychiatry
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