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https://www.readbyqxmd.com/read/29035384/effect-of-anthelmintic-treatment-on-leptin-adiponectin-and-leptin-to-adiponectin-ratio-a-randomized-controlled-trial
#1
D L Tahapary, K de Ruiter, I Martin, E A T Brienen, L van Lieshout, Y Djuardi, C C Djimandjaja, J J Houwing-Duistermaat, P Soewondo, E Sartono, T Supali, J W A Smit, M Yazdanbakhsh
Emerging evidence suggests that helminths might confer protection against the development of type 2 diabetes. We aimed to assess the role of adipokines in mediating the effect of helminths on insulin resistance. Serum samples were obtained from a randomized-controlled trial of anthelmintic treatment in an area endemic for soil-transmitted helminths (STH), Flores Island, Indonesia. In STH-infected subjects, anthelmintic treatment significantly increased the ratio of leptin to adiponectin (treatment effect factor (95% confidence interval (CI)), P-value for interaction: 1...
October 16, 2017: Nutrition & Diabetes
https://www.readbyqxmd.com/read/29028118/elevated-serum-adipsin-may-predict-unsuccessful-treatment-for-cows-milk-allergy-but-other-biomarkers-do-not
#2
Susanna Salmivesi, Marita Paassilta, Heini Huhtala, Riina Nieminen, Eeva Moilanen, Matti Korppi
AIM: This study evaluated whether 15 allergy, immunology or inflammatory markers predicted the long-term use of cows' milk or milk products seven years after the start of oral immunotherapy (OIT) for cows' milk allergy in children. METHODS: The following laboratory parameters were measured before the OIT at Tampere University Hospital, Finland, and after the six-month escalation phase: serum total immunoglobulin (Ig) E, milk-specific IgG and IgG4, eosinophil cationic protein, eosinophil-derived neurotoxin, interleukins 4, 5, 6,10 and 12p70 and serum adipokines adiponectin, adipsin, leptin and resistin...
October 13, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29017158/beneficial-effects-of-n-3-fatty-acids-on-cardiometabolic-and-inflammatory-markers-in-type-2-diabetes-mellitus-a-randomized-placebo-controlled-double-blind-clinical-trial
#3
Maryam Mazaherioun, Mahmoud Djalali, Fariba Koohdani, Mohammad Hassan Javanbakht, Mahnaz Zarei, Maani Beigy, Samaneh Ansari, Neda Rezvan, Ahmad Saedisomeolia
OBJECTIVE: To determine the effect of n-3 polyunsaturated fatty acids (n-3PUFAs) supplementation on circulatory resistin and monocyte chemoattractant 1 (MCP-1) levels in type 2 diabetes mellitus (T2DM) patients. SUBJECTS AND METHODS: This was a ten-week, placebo-controlled, double-blind, randomized trial of n-3 PUFAs (2700 mg/day) vs. placebo (soft gels containing 900 mg of edible paraffin). Forty-four (44) T2DM patients were supplemented with n-3 PUFAs and another 44 patients received placebo (3 patients discontinued the trial)...
October 10, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28991674/body-composition-and-adipokines-plasma-levels-in-patients-with-myasthenia-gravis-treated-with-high-cumulative-glucocorticoid-dose
#4
Nayara Felicidade Tomaz Braz, Natalia Pessoa Rocha, Érica Leandro Marciano Vieira, Rodrigo Santiago Gomez, Adriana Maria Kakehasi, Antonio Lucio Teixeira
This study aimed to evaluate changes in body composition, i.e. overweight, obesity, fat accumulation and low lean body mass and plasma levels of adipokines in patients with MG. The study enrolled 80 patients with MG, and 62 controls. Body fat mass and body lean mass was analyzed by dual-energy X-ray absorptiometry technique (DXA). Plasma levels of leptin were analyzed by Luminex® and adiponectin and resistin were analyzed by ELISA. The mean age of patients with MG was 41.9years, with 13.5years of length of illness, and mean cumulative dose of glucocorticoids 38,123mg...
October 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28991224/resistin-facilitates-breast-cancer-progression-via-tlr4-mediated-induction-of-mesenchymal-phenotypes-and-stemness-properties
#5
C-H Wang, P-J Wang, Y-C Hsieh, S Lo, Y-C Lee, Y-C Chen, C-H Tsai, W-C Chiu, S Chu-Sung Hu, C-W Lu, Y-F Yang, C-C Chiu, F Ou-Yang, Y-M Wang, M-F Hou, S-Sf Yuan
Growing evidence indicates that resistin-an obesity-related cytokine-is upregulated in breast cancer patients, yet its impact on breast cancer behavior remains to be ascertained. Similarly, Toll-like receptor 4 (TLR4) has been implicated in breast cancer progression, however, its clinically relevant endogenous ligand remains elusive. In this study, we observed that high serum resistin levels in breast cancer patients positively correlated with tumor stage, size and lymph node metastasis. These findings were replicated in animal models of breast cancer tumorigenesis and metastasis...
October 9, 2017: Oncogene
https://www.readbyqxmd.com/read/28985620/serum-levels-of-leptin-adiponectin-and-resistin-in-patients-with-ankylosing-spondylitis-a-systematic-review-and-meta-analysis
#6
REVIEW
Jiajia Yang, Xu Zhang, Yubo Ma, Meng Wu, Xingxing Hu, Renfang Han, Yaping Yuan, Mengmeng Wang, Mengya Chen, Shanqun Jiang, Jingjing Tong, Shengqian Xu, Jianhua Xu, Zongwen Shuai, Yanfeng Zou, Faming Pan
OBJECTIVES: Various studies have researched the serum levels of leptin, adiponectin and resistin in patients with ankylosing spondylitis (AS), but the results were inconclusive. The purpose of this study was to systematically evaluate the correlations between serum levels of these adipokines and AS. METHODS: Electronic databases were retrieved to search relevant publications. Pooled standard mean difference (SMD) with 95% confidence interval (CI) was calculated by the random-effect model...
October 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28984888/consumption-of-a-single-serving-of-red-raspberries-per-day-reduces-metabolic-syndrome-parameters-in-high-fat-fed-mice
#7
T Luo, O Miranda-Garcia, G Sasaki, N F Shay
Using an animal model for diet-induced metabolic disease, we have shown previously that the addition of raspberry juice concentrate (RJC) and raspberry puree concentrate (RPC) at a level of 10% of kcal, equivalent to four servings per day, to an obesogenic high-fat, western-style diet (HF) significantly reduced body weight gain, serum resistin levels, and altered the expression of hepatic genes related to lipid metabolism and oxidative stress. This study was designed to examine the effect of a lower level of RJC or RPC consumption, at a level representing a single serving of food per day (2...
October 6, 2017: Food & Function
https://www.readbyqxmd.com/read/28980898/resistin-a-possible-biomarker-of-organ-involvement-in-systemic-sclerosis-patients
#8
Karolina Sawicka, Małgorzata Michalska-Jakubus, Małgorzata Kowal, Emilia Potembska, Dorota Krasowska
OBJECTIVES: Resistin has strong pro-inflammatory and profibrotic properties, which are key pathogenetic processes in systemic sclerosis. We hypothesised that resistin may be associated with organ involvement and inflammatory process in SSc patients. To address this hypothesis, the aim of this study was to define serum resistin levels in SSc patients and control group and determine the correlation between this adipokine and internal organ involvement in SSc patients. METHODS: The study enrolled 48 Caucasian female patients with SSc and 38 healthy subjects of control group...
September 18, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28973871/resistin-like-molecule-%C3%AE-is-a-bactericidal-protein-that-promotes-spatial-segregation-of-the-microbiota-and-the-colonic-epithelium
#9
Daniel C Propheter, Andrew L Chara, Tamia A Harris, Kelly A Ruhn, Lora V Hooper
The mammalian intestine is colonized by trillions of bacteria that perform essential metabolic functions for their hosts. The mutualistic nature of this relationship depends on maintaining spatial segregation between these bacteria and the intestinal epithelial surface. This segregation is achieved in part by the presence of a dense mucus layer at the epithelial surface and by the production of antimicrobial proteins that are secreted by epithelial cells into the mucus layer. Here, we show that resistin-like molecule β (RELMβ) is a bactericidal protein that limits contact between Gram-negative bacteria and the colonic epithelial surface...
September 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28967613/relationship-of-serum-leptin-with-some-biochemical-anthropometric-parameters-and-abdominal-fat-volumes-as-measured-by-magnetic-resonance-imaging
#10
Nawal S Hijjawi, Ali M Al-Radaideh, Kholoud I Al-Fayomi, Nisreen A Nimer, Hadeel A Alabadi, Rana M Al-Zu'bi, Lana M Agraib, Sabika S Allehdan, Reema F Tayyem
AIMS: To measure the level of leptin in volunteers and correlate it with several anthropometric, biochemical variables and abdominal fat volumes. METHODS: The level of leptin was investigated in 167 disease-free volunteers. Serum levels of IL-6, adiponectin, and resistin, blood lipid profile (cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) were determined. Waist circumference (WC) was measured using tape and magnetic resonance imaging (MRI) images...
September 22, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28958596/increased-levels-of-inflammatory-plasma-markers-and-obesity-risk-in-a-mouse-model-of-down-syndrome
#11
REVIEW
M Fructuoso, L Rachdi, E Philippe, R G Denis, C Magnan, H Le Stunff, N Janel, M Dierssen
Down syndrome (DS) is caused by the trisomy of human chromosome 21 and is the most common genetic cause of intellectual disability. In addition to the intellectual deficiencies and physical anomalies, DS individuals present a higher prevalence of obesity and subsequent metabolic disorders than healthy adults. There is increasing evidence from both clinical and experimental studies indicating the association of visceral obesity with a pro-inflammatory status and recent studies have reported that obese people with DS suffer from low-grade systemic inflammation...
September 25, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28953247/anti-adipogenic-effects-on-3t3-l1-cells-and-zebrafish-by-tanshinone-iia
#12
Yu-Kyoung Park, Brice Wilfried Obiang-Obounou, Jinho Lee, Tae-Yun Lee, Myung-Ae Bae, Kyu-Seok Hwang, Kyung-Bok Lee, Jong-Soon Choi, Byeong-Churl Jang
Tanshinone IIA is a diterpene quinone isolated from the roots of Salviamiltiorrhiza bunge that has traditionally been used in China for the treatment of cardiovascular and cerebrovascular disorders. Although there is recent evidence showing that tanshinone IIA has an anti-obesity effect, its underlying mechanism of anti-obesity effect is poorly understood. Here, we investigated the effect of tanshinone IIA on lipid accumulation in 3T3-L1 preadipocytes and zebrafish. Notably, tanshinone IIA at 10 μM concentration greatly reduced lipid accumulation and triglyceride (TG) contents during 3T3-L1 preadipocyte differentiation, suggesting its anti-adipogenic effect...
September 27, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28950020/thymoquinone-ameliorates-diabetic-phenotype-in-diet-induced-obesity-mice-via-activation-of-sirt-1-dependent-pathways
#13
Shpetim Karandrea, Huquan Yin, Xiaomei Liang, Angela L Slitt, Emma A Heart
Thymoquinone, a natural occurring quinone and the main bioactive component of plant Nigella sativa, undergoes intracellular redox cycling and re-oxidizes NADH to NAD+. TQ administration (20 mg/kg/bw/day) to the Diet-Induced Obesity (DIO) mice reduced their diabetic phenotype by decreasing fasting blood glucose and fasting insulin levels, and improved glucose tolerance and insulin sensitivity as evaluated by oral glucose and insulin tolerance tests (OGTT and ITT). Furthermore, TQ decreased serum cholesterol levels and liver triglycerides, increased protein expression of phosphorylated Akt, decreased serum levels of inflammatory markers resistin and MCP-1, and decreased NADH/NAD+ ratio...
2017: PloS One
https://www.readbyqxmd.com/read/28940978/effects-of-short-term-add-on-ezetimibe-to-statin-treatment-on-expression-of-adipokines-and-inflammatory-markers-in-diabetic-and-dyslipidemic-patients
#14
Elizandra Silva Guimarães, Alvaro Cerda, Egidio Lima Dorea, Marcia Martins Silveira Bernik, Maria Cecilia Gusukuma, Gelba Almeida Pinto, Cristina Moreno Fajardo, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
AIM: The influence of short term add-on ezetimibe to simvastatin treatment on expression of adipokines and inflammatory markers was investigated in diabetic and non-diabetic patients with hypercholesterolemia. METHOD: Hypercholesterolemic non-diabetic (HC, n=37) and diabetic (DM, n=47) patients were treated with simvastatin (SV, 10 or 20 mg/day/8-weeks) and then SV plus ezetimibe (SV+EZ, 10 mg each/day/4-weeks). Serum lipids, glycemic profile and inflammatory markers (hsCRP, adiponectin, resistin, VCAM-1 and ICAM-1) were evaluated before and after the add-on-ezetimibe therapy...
September 21, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28938461/adipokines-and-their-receptors-are-widely-expressed-and-distinctly-regulated-by-the-metabolic-environment-in-the-prostate-of-male-mice-direct-role-under-normal-and-tumoral-conditions
#15
André Sarmento-Cabral, Fernando L-López, Raúl M Luque
Adipose tissue-derived adipokines (i.e., leptin/adiponectin/resistin) play important roles in the regulation of several pathophysiologic processes through the activation of specific receptors. However, although adipokines and their receptors are widely distributed in many tissues and exhibit a clear modulation according to particular metabolic conditions (e.g., obesity and/or fasting), their expression, regulation, and putative action on normal prostate glands (PGs; a hormone-dependent organ tightly regulated by the endocrine-metabolic milieu) are still to be defined...
October 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28936849/-effect-of-flavonoids-from-abelmoschus-manihot-on-proliferation-differentiation-of-3t3-l1-preadipocyte-and-insulin-resistance
#16
Hong-Die Cai, Shu-Lan Su, Sheng Guo, Yue Zhu, Da-Wei Qian, Wei-Wei Tao, Jin-Ao Duan
Abelmoschus manihot was rich in flavonoids, which has been reported the activity on protecting angiocarpy and improving renal function. This study aimed to explore the action mechanism of five flavonoids from A. manihot on how to ameliorating insulin resistance through the regulation of the glucose and expression of PPARγ, C/EBPα, SREBP-1, resistin, visfatin, adiponectin in 3T3-L1 adipocytes. After the 3T3-L1 preadipocytes were differentiated into mature adipocytes, insulin resistance model was built. Insulin resistance adipocytes were treated with 5, 100 μmol•L⁻¹ quercetin, isoquercitrin, hyperoside, quercitrin-3'-O-glucoside, gossypetin-8-O-β-glucoside...
December 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28935125/maternal-circulating-adipokine-profile-and-insulin-resistance-in-women-at-high-risk-of-developing-gestational-diabetes-mellitus
#17
Kym J Guelfi, Ming Jing Ong, Shaofu Li, Karen E Wallman, Dorota A Doherty, Paul A Fournier, John P Newnham, Jeffrey A Keelan
BACKGROUND: Cytokines produced by adipose and placental tissues (adipokines) have been implicated in the development of gestational diabetes mellitus (GDM). There is, however, limited research regarding the relationship between advancing pregnancy, maternal adipokine profile, insulin resistance and the development of GDM. Furthermore, no studies have investigated these parameters in women with a history of GDM who are at the highest risk of recurrence. This study examined the circulating concentrations of a number of adipokines associated with insulin resistance at two points in pregnancy, and determined whether they were altered in women who developed GDM...
October 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28933132/effects-of-secukinumab-on-serum-adipocytokines-preliminary-data
#18
A Fassio, D Gatti, P Gisondi, G Girolomoni, O Viapiana, A Giollo, M Zamboni, M Rossini, L Idolazzi
Psoriatic arthritis (PsA) is a chronic inflammatory disease that affects joints, connective tissues and the axial skeleton. Metabolic syndrome is an independent risk factor for psoriasis (Pso) development and is associated with more severe forms of Pso. Adipocytokines are secreted by white adipose tissue and are thought to link obesity with the development of metabolic and cardiovascular diseases. Secukinumab is a new monoclonal antibody with a different mechanism of action. This antibody selectively binds to and neutralizes interleukin-17 (IL-17) and it has shown efficacy in the treatment of PsA...
September 21, 2017: Reumatismo
https://www.readbyqxmd.com/read/28933065/cerebrovascular-disease-consequences-of-obesity-induced-endothelial-dysfunction
#19
Liliana Letra, Cristina Sena
Despite the well-known global impact of overweight and obesity in the incidence of cerebrovascular disease, many aspects of this association are still inconsistently defined. In this chapter we aim to present a critical review on the links between obesity and both ischemic and hemorrhagic stroke and discuss its influence on functional outcomes, survival, and current treatments to acute and chronic stroke. The role of cerebrovascular endothelial function and respective modulation is also described as well as its laboratory and clinical assessment...
2017: Advances in Neurobiology
https://www.readbyqxmd.com/read/28924543/effect-of-the-pro12ala-polymorphism-of-the-peroxisome-proliferator-activated-receptor-%C3%AE-2-gene-on-lipid-profile-and-adipokines-levels-in-obese-subjects
#20
E Becer, A Çırakoğlu
Peroxisome proliferator-activated receptor γ (PPARγ) is a key regulator of metabolism, adipokines production and secretion. The aim of this study was to investigate the association between the PPARγ2 gene Pro12Ala polymorphism in obesity in terms of body mass index (BMI), lipid parameters, homeostasis model assessment of insulin resistance (HOMA-IR), serum lipid, leptin, adiponectin, resistin and chemerin levels. The study included 160 obese and 140 non obese subjects. The Pro12Ala polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP)...
June 30, 2017: Balkan Journal of Medical Genetics: BJMG
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