Read by QxMD icon Read


Ralf Kittler, Christine Shiang, Ryan Hutchinson, Rahul K Kollipara, Payal Kapur, Francis Franto, Yair Lotan
Purpose: Low-grade (LG) urothelial carcinomas of the bladder (UCB) are common malignancies that are costly to surveil and rarely progress to life threatening, high-grade (HG) malignancies. It is unknown if the progression of LG to HG is a result of second primary tumors or transformation of existing LG tumors. We examined tumor genetics in patients with grade progression in urothelial carcinoma and compared to patients with no progression. Results: Five patients were identified with progression...
February 6, 2018: Oncotarget
Yoshiji Yamada, Jun Sakuma, Ichiro Takeuchi, Yoshiki Yasukochi, Kimihiko Kato, Mitsutoshi Oguri, Tetsuo Fujimaki, Hideki Horibe, Masaaki Muramatsu, Motoji Sawabe, Yoshinori Fujiwara, Yu Taniguchi, Shuichi Obuchi, Hisashi Kawai, Shoji Shinkai, Seijiro Mori, Tomio Arai, Masashi Tanaka
We performed exome-wide association studies to identify genetic variants that influence systolic or diastolic blood pressure or confer susceptibility to hypertension in Japanese. The exome-wide association studies were performed with the use of Illumina HumanExome-12 DNA Analysis BeadChip or Infinium Exome-24 BeadChip arrays and with 14,678 subjects, including 8215 individuals with hypertension and 6463 controls. The relation of genotypes of 41,843 single nucleotide polymorphisms to systolic or diastolic blood pressure was examined by linear regression analysis...
June 27, 2017: Oncotarget
Jihye Kim, Bermseok Oh, Ji Eun Lim, Mi Kyung Kim
Previously, genetic polymorphisms of C12orf51 (HECTD4) (rs2074356 and/or rs11066280) have been shown to be related to alcohol consumption and type 2 diabetes (T2D). This study aimed to prospectively examine whether C12orf51 had an interaction with or independent effect on alcohol consumption and the risk of T2D. The present study included 3,244 men and 3,629 women aged 40 to 69 years who participated in the Korean Genome and Epidemiology Study (KoGES)_Ansan and Ansung Study. Cox proportional hazards models were used to estimate HRs and 95% CIs for T2D...
2016: PloS One
Seongwon Cha, Ah Yeon Park, Changsoo Kang
The thoracic-to-hip circumference ratio (THR) is an anthropometric marker recently described as a predictor of type 2 diabetes. In this study, we performed a genome-wide association study (GWAS) followed by confirmatory analyses to identify genetic markers associated with THR. A total of 7,240 Korean subjects (4,988 for the discovery stage and 2,252 for the confirmatory analyses) were recruited for this study, and genome-wide single nucleotide polymorphism (SNP) genotyping of the initial 4,988 individuals was performed using Affymetrix Human SNP array 5...
2015: PloS One
Huan Zhang, Xing-Bo Mo, Tan Xu, Xiao-Qing Bu, Shu-Feng Lei, Yong-Hong Zhang
Hypertension is a common disorder and one of the most important risk factors for cardiovascular diseases. The aim of this study was to identify more novel genes for blood pressure. Based on the publically available SNP-based P values of a meta-analysis of genome-wide association studies, we performed an initial gene-based association study in a total of 69,395 individuals. To find supplementary evidence to support the importance of the identified genes, we performed GRAIL (gene relationships among implicated loci) analysis, protein-protein interaction analysis, functional annotation clustering analysis, coronary artery disease association analysis, and other bioinformatics analyses...
June 2015: G3: Genes—Genomes—Genetics
Aldi T Kraja, Daniel I Chasman, Kari E North, Alexander P Reiner, Lisa R Yanek, Tuomas O Kilpeläinen, Jennifer A Smith, Abbas Dehghan, Josée Dupuis, Andrew D Johnson, Mary F Feitosa, Fasil Tekola-Ayele, Audrey Y Chu, Ilja M Nolte, Zari Dastani, Andrew Morris, Sarah A Pendergrass, Yan V Sun, Marylyn D Ritchie, Ahmad Vaez, Honghuang Lin, Symen Ligthart, Letizia Marullo, Rebecca Rohde, Yaming Shao, Mark A Ziegler, Hae Kyung Im, Renate B Schnabel, Torben Jørgensen, Marit E Jørgensen, Torben Hansen, Oluf Pedersen, Ronald P Stolk, Harold Snieder, Albert Hofman, Andre G Uitterlinden, Oscar H Franco, M Arfan Ikram, J Brent Richards, Charles Rotimi, James G Wilson, Leslie Lange, Santhi K Ganesh, Mike Nalls, Laura J Rasmussen-Torvik, James S Pankow, Josef Coresh, Weihong Tang, W H Linda Kao, Eric Boerwinkle, Alanna C Morrison, Paul M Ridker, Diane M Becker, Jerome I Rotter, Sharon L R Kardia, Ruth J F Loos, Martin G Larson, Yi-Hsiang Hsu, Michael A Province, Russell Tracy, Benjamin F Voight, Dhananjay Vaidya, Christopher J O'Donnell, Emelia J Benjamin, Behrooz Z Alizadeh, Inga Prokopenko, James B Meigs, Ingrid B Borecki
Metabolic syndrome (MetS) has become a health and financial burden worldwide. The MetS definition captures clustering of risk factors that predict higher risk for diabetes mellitus and cardiovascular disease. Our study hypothesis is that additional to genes influencing individual MetS risk factors, genetic variants exist that influence MetS and inflammatory markers forming a predisposing MetS genetic network. To test this hypothesis a staged approach was undertaken. (a) We analyzed 17 metabolic and inflammatory traits in more than 85,500 participants from 14 large epidemiological studies within the Cross Consortia Pleiotropy Group...
August 2014: Molecular Genetics and Metabolism
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"