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thoracic medicine

Tomasz Sozański, Alicja Z Kucharska, Andrzej Rapak, Dorota Szumny, Małgorzata Trocha, Anna Merwid-Ląd, Stanisław Dzimira, Tomasz Piasecki, Narcyz Piórecki, Jan Magdalan, Adam Szeląg
BACKGROUND AND AIMS: Cardiovascular benefits of fruits are attributed mainly to their (poly)phenolic constituents, especially anthocyanins. The main aim of our study is to compare effects of iridoids and anthocyanins from one fruit on diet-induced atherosclerosis. The cornelian cherry is a native or cultivated plant that grows in many European countries, used in cuisine and folk medicine. In our previous study, we showed its constituents and proved that oral administration of lyophilized fruits to hypercholesterolemic rabbits had preventive effects on atherosclerosis through the activation of PPARα expression...
October 5, 2016: Atherosclerosis
Curtis H Weiss, Jerry A Krishnan, David H Au, Bruce G Bender, Shannon S Carson, Adithya Cattamanchi, Michelle M Cloutier, Colin R Cooke, Karen Erickson, Maureen George, Joe K Gerald, Lynn B Gerald, Christopher H Goss, Michael K Gould, Robert Hyzy, Jeremy M Kahn, Brian S Mittman, Erika M Mosesón, Richard A Mularski, Sairam Parthasarathy, Sanjay R Patel, Cynthia S Rand, Nancy S Redeker, Theodore F Reiss, Kristin A Riekert, Gordon D Rubenfeld, Judith A Tate, Kevin C Wilson, Carey C Thomson
BACKGROUND: Many advances in health care fail to reach patients. Implementation science is the study of novel approaches to mitigate this evidence-to-practice gap. METHODS: The American Thoracic Society (ATS) created a multidisciplinary ad hoc committee to develop a research statement on implementation science in pulmonary, critical care, and sleep medicine. The committee used an iterative consensus process to define implementation science and review the use of conceptual frameworks to guide implementation science for the pulmonary, critical care, and sleep community and to explore how professional medical societies such as the ATS can promote implementation science...
October 15, 2016: American Journal of Respiratory and Critical Care Medicine
Jennifer F Ha, Waseem Ostwani, Glenn Green
INTRODUCTION: With the advent of improved neonatal and pediatric intensive care management, tracheostomy is increasingly performed in children requiring prolonged ventilation. Even though tracheostomy is generally a safe procedure, there remains mortality and morbidity associated with it. OBJECTIVE: We report a rare complication of a tracheostomy tube resulting in extensive erosion and posterior tracheal false pouch secondary to a large tracheostomy tube and high positive end expiratory pressure in a 12-month-old infant...
November 2016: International Journal of Pediatric Otorhinolaryngology
Sana Salah, Houda Migaou, Zied Belaaj, Soumaya Boudokhane, Anis Jellad, Abderrazak Abid, Zohra Ben Salah Frih
OBJECTIVE: Winging of the scapula has a variety of causes and a variable prognosis. It contributes to a disruption of the scapulohumeral rhythm with a decreased flexion and abduction of the upper extremity and a source of a considerable pain. This condition can affect the ability to perform activities of daily living. The most common cause of scapula winging is serratus anterior paralysis resulting from a lesion of the long thoracic nerve. The rupture of the muscle itself remains uncommon...
September 2016: Annals of Physical and Rehabilitation Medicine
Thomas Küstner, Christian Würslin, Martin Schwartz, Petros Martirosian, Sergios Gatidis, Cornelia Brendle, Ferdinand Seith, Fritz Schick, Nina F Schwenzer, Bin Yang, Holger Schmidt
PURPOSE: To enable fast and flexible high-resolution four-dimensional (4D) MRI of periodic thoracic/abdominal motion for motion visualization or motion-corrected imaging. METHODS: We proposed a Cartesian three-dimensional k-space sampling scheme that acquires a random combination of k-space lines in the ky/kz plane. A partial Fourier-like constraint compacts the sampling space to one half of k-space. The central k-space line is periodically acquired to allow an extraction of a self-navigated respiration signal used to populate a k-space of multiple breathing positions...
September 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
Todd C Crawford, J Trent Magruder, Joshua C Grimm, Christopher M Sciortino, Kaushik Mandal, Kenton J Zehr, Duke E Cameron, Glenn J Whitman, John V Conte
BACKGROUND: Mediastinal reexplorations for bleeding are associated with significant morbidity and mortality. This study hypothesized that bleeding patients who undergo delayed chest closure after an initial operation experience similar outcomes in comparison with patients who have initial chest closure and later require an unplanned reexploration. METHODS: This study included all patients in the Johns Hopkins University School of Medicine (Baltimore, MD) institutional Society of Thoracic Surgeons (STS) database who underwent cardiac surgical procedures or thoracic transplantation from 2011 to June 2014, had an intraoperative red blood cell transfusion requirement of 2 units or more, and required mediastinal reexploration for bleeding...
September 22, 2016: Annals of Thoracic Surgery
Ze-Rui Zhao, Zheng Li, Dong-Rong Situ, Calvin S H Ng
The concept of personalized medicine, which aims to provide patients with targeted therapies while greatly reducing surgical trauma, is gaining popularity among Asian clinicians. Single port video-assisted thoracic surgery (VATS) has rapidly gained popularity in Hong Kong for major lung resections, despite bringing new challenges such as interference between surgical instruments and insertion of the optical source through a single incision. Novel types of endocutters and thoracoscopes can help reduce the difficulties commonly encountered during single-port VATS...
August 2016: Journal of Thoracic Disease
Xia Che, Xin Wang, Junyan Zhang, Chengfeng Peng, Yilan Zhen, Xu Shao, Gongliang Zhang, Liuyi Dong
PURPOSE: The aim of this study was to explore the cardioprotective effect of vitexin on chronic myocardial ischemia/reperfusion injury in rats and potential mechanisms. METHODS: A chronic myocardial ischemia/reperfusion injury model was established by ligating left anterior descending coronary for 60 minutes, and followed by reperfusion for 14 days. After 2 weeks ischemia/reperfusion, cardiac function was measured to assess myocardial injury. The level of ST segment was recorded in different periods by electrocardiograph...
2016: American Journal of Translational Research
Kimberly J Dunham-Snary, Danchen Wu, Edward A Sykes, Amar Thakrar, Leah Rg Parlow, Jeffrey D Mewburn, Joel L Parlow, Stephen L Archer
Hypoxic pulmonary vasoconstriction (HPV) is a homeostatic mechanism that is intrinsic to the pulmonary vasculature. Intrapulmonary arteries constrict in response to alveolar hypoxia, diverting blood to better-oxygenated lung segments, thereby optimizing ventilation-perfusion matching and systemic oxygen delivery. In response to alveolar hypoxia, a mitochondrial sensor dynamically changes reactive oxygen species and redox couples in PASMC. This inhibits potassium channels, depolarizes PASMC, activates voltage-gated calcium channels, and increases cytosolic calcium, causing vasoconstriction...
September 16, 2016: Chest
Josephina A N Meester, Geert Vandeweyer, Isabel Pintelon, Martin Lammens, Lana Van Hoorick, Simon De Belder, Kathryn Waitzman, Luciana Young, Larry W Markham, Julie Vogt, Julie Richer, Luc M Beauchesne, Sheila Unger, Andrea Superti-Furga, Milan Prsa, Rami Dhillon, Edwin Reyniers, Harry C Dietz, Wim Wuyts, Geert Mortier, Aline Verstraeten, Lut Van Laer, Bart L Loeys
PURPOSE: Thoracic aortic aneurysm and dissection (TAAD) is typically inherited in an autosomal dominant manner, but rare X-linked families have been described. So far, the only known X-linked gene is FLNA, which is associated with the periventricular nodular heterotopia type of Ehlers-Danlos syndrome. However, mutations in this gene explain only a small number of X-linked TAAD families. METHODS: We performed targeted resequencing of 368 candidate genes in a cohort of 11 molecularly unexplained Marfan probands...
September 15, 2016: Genetics in Medicine: Official Journal of the American College of Medical Genetics
Shangshan Li, Chunjun Liu, Dali Mu, Minqiang Xin, Su Fu, Lin Chen, Jie Luan
BACKGROUND: The range of the medial dissection forbidden zone, defined as the no-touch zone in this study, is of great importance in breast augmentation. Currently, 30 mm of the no-touch zone is marked and the pocket dissection does not pass medial to this zone, which lacks anatomical evidence. This study aimed to determine the optimal range of the no-touch zone in breast augmentation by precisely locating relevant anatomical structures. METHODS: Preoperative multidetector-row CT angiography (MDCTA) was performed in 36 Chinese female patients who were to receive breast reconstruction...
September 8, 2016: Aesthetic Plastic Surgery
Małgorzata Szewczyńska, Małgorzata Pośniak, Emilia Pągowska
BACKGROUND: The article presents the results of the determination of the inhalable and thoracic fraction of sulfuric acid(VI) in 3 workplaces producing or processing this chemical. MATERIAL AND METHODS: To collect thoracic fractions of sulfuric acid(VI) Parallel Particle Impactor (PPI) was used. To isolate inhalable fraction of sulfuric acid(VI) from the air we used a sampler developed at the Institute of Occupational Medicine (IOM), United Kingdom. Parallel Particle Impactor and IOM samplers worked with pumps at a flow of 2 l/min...
2016: Medycyna Pracy
Gabriele Margiotta, Alessio Coletti, Simona Severini, Federica Tommolini, Massimo Lancia
Pulmonary ThromboEmolism (PTE) is an important disease for legal medicine. Because of their sudden lethal onset, generally medicolegal autopsies show few clinical information when PTE is the cause of death. During medicolegal autopsies, the autopsy operator must answer to important questions. For example, autopsy operator can need to assess the casual relationship between PTE and recent accident, such as trauma or long air travel. Furthermore, the autopsy operator needs to investigate the pathology of PTE as a cause of sudden cardiovascular death...
September 13, 2016: Advances in Experimental Medicine and Biology
Arvin Wali, Gabriel Wardi, Daniel Crouch
No abstract text is available yet for this article.
July 2016: Journal of Thoracic Disease
Hong Zhang, Zhanhai Wan, Xiang Yan, De-Gui Wang, Yufang Leng, Yongqiang Liu, Yan Zhang, Haijun Zhang, Xuena Han
Lung ischemia-reperfusion injury remains a problem in thoracic surgery, as minimal progress has been made concerning its prevention and control. In the present study, the protective effects and the underlying mechanism of Shenfu injection preconditioning on a rat lung ischemia-reperfusion model was investigated. Shenfu injection is a well-known Chinese traditional medicine, which is composed of Red Radix Ginseng and Radix Aconitum carmichaelii, with ginseng saponin and aconitum alkaloids as the active ingredients...
September 2016: Experimental and Therapeutic Medicine
Stefan S Jeppesen, Niels-Chr G Hansen, Tine Schytte, Morten Nielsen, Olfred Hansen
OBJECTIVES: Chronic obstructive pulmonary disease (COPD) and non-small cell lung cancer (NSCLC) are often co-existing diseases with poor prognosis. The aim of this study was to compare survival in COPD patients with localized NSCLC treated with stereotactic body radiotherapy (NSCLC group) with COPD patients without a malignant diagnosis (non-malignant group). MATERIALS AND METHODS: The NSCLC group was prospectively recorded at the Department of Oncology from 2007 to 2013...
October 2016: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
Alison E Turnbull, Sarina K Sahetya, Dale M Needham
OBJECTIVE: To develop a list of non-emergent, potentially harmful interventions commonly performed in ICUs that require a clear understanding of patients' treatment goals. BACKGROUND: A 2016 policy statement from the American Thoracic Society and American College of Critical Care Medicine calls on intensivists to engage in shared decision-making when "making major treatment decisions that may be affected by personal values, goals, and preferences." METHODS: A three-round modified Delphi consensus process was conducted via a panel of 6 critical care physicians, 6 ICU nurses, 6 former ICU patients, and 6 family members from 6 academic and community-based medical institutions in the U...
September 1, 2016: Heart & Lung: the Journal of Critical Care
Rahila Qayyum, Hafiz Misbah-Ud-Din Qamar, Shamim Khan, Umme Salma, Taous Khan, Abdul Jabbar Shah
BACKGROUND: Urtica dioica has traditionally been used in the management of cardiovascular disorders especially hypertension. The aim of this study was to explore pharmacological base of its use in hypertension. METHODS: Crude methanolic extract of U. dioica (Ud.Cr) and its fractions (Ud.EtAc, Ud.nHex, Ud.Chl and Ud.Aq) were tested in vivo on normotensive and hypertensive rats under anesthesia for blood pressure lowering effect. In-vitro experiments on rat and rabbit aortae were employed to probe the vasorelaxation mechanism(s)...
2016: Journal of Translational Medicine
Andreas Beckmann, Anne-Katrin Funkat, Jana Lewandowski, Michael Frie, Markus Ernst, Khosro Hekmat, Wolfgang Schiller, Jan F Gummert, Armin Welz
On the basis of a long-standing voluntary registry, which was founded by the German Society for Thoracic and Cardiovascular Surgery (GSTCVS), well-defined data of all heart, thoracic, and vascular surgery procedures performed in 78 German heart surgery departments during 2015 are analyzed. In 2015, a total of 103,967 heart surgery procedures (implantable cardioverter defibrillator, pacemaker, and extracardiac procedures without ECC excluded) were submitted to the database. Approximately 14.8% of the patients were at least 80 years old, resulting in an increase of 0...
September 2016: Thoracic and Cardiovascular Surgeon
J A Capdevila, M Guembe, J Barberán, A de Alarcón, E Bouza, M C Fariñas, J Gálvez, M A Goenaga, F Gutiérrez, M Kestler, P Llinares, J M Miró, M Montejo, P Muñoz, M Rodríguez-Creixems, D Sousa, J Cuenca, C A Mestres
The use of endovascular catheters is a routine practice in secondary and tertiary care level hospitals. Short peripheral catheters have been found to be associated with the risk of nosocomial bacteremia resulting in morbidity and mortality. Staphyloccus aureus is mostly associated with peripheral catheter insertion. This Consensus Document has been elaborated by a panel of experts of the Spanish Society of Cardiovascular Infections in cooperation with experts from the Spanish Society of Internal Medicine, Spanish Society of Chemotherapy and Spanish Society of Thoracic-Cardiovascular Surgery and aims at define and establish the norm for management of short duration peripheral vascular catheters...
August 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
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