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https://www.readbyqxmd.com/read/28945054/intracranial-stereotactic-radiosurgery
#1
Andrew A Fanous, Dheerendra Prasad, David Mathieu, Andrew J Fabiano
Stereotactic radiosurgery (SRS) is the use of a single high dose of radiation, stereotactically directed to an intracranial region of interest, in order to create a lesion or obliterate a preexisting one. This technology has evolved over the years into the use of multiple radiation sources oriented at a variety of angles, thus permitting the creation of various treatment target shapes. This allows for non-open surgical treatment of intracranial pathologies, which significantly decreases the risk of morbidity...
September 22, 2017: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/28945025/-dna-marker-assisted-selection-of-medicinal-plants-%C3%A2-breeding-research-of-disease-resistant-cultivars-of-panax-notoginseng
#2
Lin-Lin Dong, Zhong-Jian Chen, Yong Wang, Fu-Gang Wei, Lian-Juan Zhang, Jiang Xu, Guang-Fei Wei, Rui Wang, Juan Yang, Wei-Lin Liu, Xi-Wen Li, Yu-Qi Yu, Shi-Lin Chen
DNA marker-assisted selection of medicinal plants is based on the DNA polymorphism, selects the DNA sequences related to the phenotypes such as high yields, superior quality, stress-resistance and so on according to the technologies of molecular hybridization, polymerase chain reaction and high-throughput sequencing, and assists the breeding of new cultivars. This study bred the first disease-resistant cultivar of notoginseng "Miaoxiang Kangqi 1" using the technology of DNA marker-assisted selection of medicinal plants and systematic breeding...
January 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28944979/dosimetric-validation-of-monaco-treatment-planning-system-on-an-elekta-versahd-linear-accelerator
#3
Ganesh Narayanasamy, Daniel L Saenz, Dewayne Defoor, Niko Papanikolaou, Sotirios Stathakis
The purpose of this study is to perform dosimetric validation of Monaco treatment planning system version 5.1. The Elekta VersaHD linear accelerator with high dose rate flattening filter-free photon modes and electron energies was used in this study. The dosimetric output of the new Agility head combined with the FFF photon modes warranted this investigation into the dosimetric accuracy prior to clinical usage. A model of the VersaHD linac was created in Monaco TPS by Elekta using commissioned beam data including percent depth dose curves, beam profiles, and output factors...
September 25, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28944971/a-parallel-mr-imaging-method-using-multilayer-perceptron
#4
Kinam Kwon, Dongchan Kim, HyunWook Park
PURPOSE: To reconstruct MR images from subsampled data, we propose a fast reconstruction method using the multilayer perceptron (MLP) algorithm. METHODS AND MATERIALS: We applied MLP to reduce aliasing artifacts generated by subsampling in k-space. The MLP is learned from training data to map aliased input images into desired alias-free images. The input of the MLP is all voxels in the aliased lines of multi-channel real and imaginary images from the subsampled k-space data, and the desired output is all voxels in the corresponding alias-free line of the root-sum-of-squares of multi-channel images from fully-sampled k-space data...
September 25, 2017: Medical Physics
https://www.readbyqxmd.com/read/28944964/wnt-%C3%AE-catenin-and-erk-pathway-activation-a-possible-mechanism-of-photobiomodulation-therapy-with-light-emitting-diodes-that-regulate-the-proliferation-of-human-outer-root-sheath-cells
#5
Jung E Kim, Young J Woo, Ki M Sohn, Kwan H Jeong, Hoon Kang
BACKGROUND: Outer root sheath cells (ORSCs) play important roles in maintaining hair follicle structure and provide support for the bulge area. The hair growth promoting effects of photobiomodulation therapy (PBMT) have been reported, but the mechanisms for this in human ORCs (hORSCs) have rarely been studied. OBJECTIVE: The aim of this study was to investigate the effect of various wavelengths of light-emitting diode (LED) irradiation on human ORSCs (hORSCs). METHODS: LED irradiation effects on hORSC proliferation and migration were examined with MTT assay, BrdU incorporation assay and migration assays...
September 25, 2017: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/28944884/antioxidant-and-anti%C3%A2-inflammatory-effects-of-dhk%C3%A2-medicated-serum-on-high-glucose%C3%A2-induced-injury-in-endothelial-cells
#6
Ziyang Zhang, Wenpei Chen, Yandong Wang, Tianqin Xiong, Chenghao Zhou, Xiaolan Yao, Baoqin Lin
It has been shown that oxidative damage and inflammation caused by hyperglycemia in endothelial cells are key factors triggering diabetic vascular complications. The aim of the present study was to investigate the antioxidant and anti‑inflammatory effects of Danhong Huayu Koufuye (DHK)‑medicated serum on high glucose (HG)‑induced injury in endothelial cells, and examine its underlying mechanisms. EA. hy926 cells were treated with normal glucose, HG, or HG with DHK‑medicated serum. Cell viability was assessed using the MTT method...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944827/cerebral-ischemia-reperfusion-injury-induces-airway-mucus-hypersecretion-in-rats-and-activates-il%C3%A2-13%C3%A2-associated-inflammatory-mechanisms
#7
Baoning Xu, Lei Zhang, Yuqin Che, Chengyang Song, Wenjun Jiang, Jianhua Fan, Dali Tian
The majority of patients that suffer a stroke have excessive sputum, which accelerates the development of pulmonary complications. However, it is unclear whether cerebral ischemia and reperfusion (I/R) injury induces mucus hypersecretion, and the potential role of inflammation remains unknown. In the present study, the reversible middle cerebral artery occlusion model was applied in rats to induce cerebral I/R injury. The rats were grouped according to the duration of reperfusion (6, 12, 24, 48 and 72 h). Neurological dysfunction was evaluated by Longa scoring and lung dry‑to‑wet weight (dw/ww) ratios were determined to reflect the degree of mucus secretion...
September 19, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944642/variability-of-gps-derived-running-performance-during-official-matches-in-elite-professional-soccer-players
#8
Hani Al Haddad, Alberto Méndez-Villanueva, Nacho Torreño, Diego Munguía-Izquierdo, Luis Suárez-Arrones
AIM: The aim of this study was to assess the match-to-match variability obtained using GPS devices, collected during official games in professional soccer players. METHODS: GPS-derived data from nineteen elite soccer players were collected over two consecutive seasons. Time-motion data for players with more than five full-match were analyzed (n=202). Total distance covered (TD), TD >13-18 km/h, TD >18-21 km/h, TD >21 km/h, number of acceleration >2.5-4 m...
September 22, 2017: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/28944616/time-course-of-the-changes-in-right-and-left-ventricle-function-and-associated-factors-after-transcatheter-closure-of-atrial-septal-defects
#9
Byung W Yoo, Jung O Kim, Lucy Y Eun, Jae Y Choi, Dong S Kim
OBJECTIVE: The purpose of this study was to evaluate the changes in right ventricle (RV) and left ventricle (LV) function after transcatheter atrial septal defect (ASD) closure and to assess the influence of the age and the amount of shunt. DESIGN: Retrospective study PATIENTS: Fifty-three adult patients who underwent transcatheter closure were enrolled, then divided into subgroups according to the age (< 40 years vs ≥ 40 years), and the amount of shunt flow (QpQs < 2...
September 24, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28944574/a-novel-approach-for-intra-operative-shape-acquisition-of-the-tibio-femoral-joints-using-3d-laser-scanning-in-computer-assisted-orthopaedic-surgery
#10
Shailesh V Joshi, Philip J Rowe
BACKGROUND: Image registration (IR) is an important process of developing a spatial relationship between pre-operative data and the physical patient in the operation theatre. Current IR techniques for Computer Assisted Orthopaedic Surgery (CAOS) are time consuming and costly. There is a need to automate and accelerate this process. METHODS: Bespoke quick, cost effective, contactless and automated 3D laser scanning techniques based on the DAVID Laserscanner method were designed...
September 24, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28944540/three-atcesa6-like-members-enhance-biomass-production-by-distinctively-promoting-cell-growth-in-arabidopsis
#11
Huizhen Hu, Ran Zhang, Shengqiu Feng, Youmei Wang, Yanting Wang, Chunfen Fan, Ying Li, Zengyu Liu, René Schneider, Tao Xia, Shi-You Ding, Staffan Persson, Liangcai Peng
Cellulose is an abundant biopolymer and a prominent constituent of plant cell walls. Cellulose is also a central component to plant morphogenesis and contributes the bulk of a plant's biomass. While cellulose synthase (CesA) genes were identified over two decades ago, genetic manipulation of this family to enhance cellulose production has remained difficult. In this study, we show that increasing the expression levels of the three primary cell wall AtCesA6-like genes (AtCesA2, -5, -6), but not AtCesA3, AtCesA9 or secondary cell wall AtCesA7, can promote the expression of major primary wall CesA genes to accelerate primary wall CesA complex (CSCs) particle movement for acquiring long microfibrils and consequently increasing cellulose production in Arabidopsis transgenic lines, as compared with wild type...
September 25, 2017: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/28944518/scenarios-reveal-pathways-to-sustain-future-ecosystem-services-in-an-agricultural-landscape
#12
Jiangxiao Qiu, Stephen R Carpenter, Eric G Booth, Melissa Motew, Samuel C Zipper, Christopher J Kucharik, Xi Chen, Steven P Loheide, Jenny Seifert, Monica G Turner
Sustaining food production, water quality, soil retention, flood and climate regulation in agricultural landscapes is a pressing global challenge given accelerating environmental changes. Scenarios are stories about plausible futures, and scenarios can be integrated with biophysical simulation models to explore quantitatively how the future might unfold. However, few studies have incorporated a wide range of drivers (e.g., climate, land-use, management, population, human diet) in spatially explicit, process-based models to investigate spatial-temporal dynamics and relationships of a portfolio of ecosystem services...
September 25, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28944514/room-temperature-decarboxylative-and-oxidative-2-2-2-annulation-of-benzoic-acids-with-alkynes-catalyzed-by-an-electron-deficient-rhodium-iii-complex
#13
Yusaku Honjo, Yu Shibata, Eiji Kudo, Tomoya Namba, Koji Masutomi, Ken Tanaka
It has been established that an electron-deficient (η5-cyclopentadienyl)rhodium(III) [CpERhIII] complex is capable of catalyzing the decarboxylative and oxidative [2+2+2] annulation of benzoic acids with alkynes to produce substituted naphthalenes at room temperature. The appropriate choice of the additive and the solvent is crucial for this transformation. This catalyst system allowed use of oxygen as a terminal oxidant and broadened the substrate scope including both aromatic and aliphatic alkynes. In this catalysis, the electron deficient nature of the CpERhIII catalyst would cause the strong rhodium-π interaction, which accelerates the decarboxylation as well as the C-H bond cleavage...
September 25, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28944203/systematic-review-and-meta-analysis-comparing-modified-cross-linking-and-standard-cross-linking-for-progressive-keratoconus
#14
Yang Liu, Yi Liu, Ying-Nan Zhang, Ai-Peng Li, Jing Zhang, Qing-Feng Liang, Ying Jie, Zhi-Qiang Pan
AIM: To compare the effectiveness and safety between modified cross-linking (MC) and standard cross-linking (SC) in mild or moderate progressive keratoconus. METHODS: Eligible studies were retrieved from four electronic databases, including CENTRAL, Clinical Trials gov, PupMed and OVID MEDLINE. We set post-surgical maximum K value (Kmax) as the primary outcome. In addition, uncorrected and corrected distant visual acuity (UDVA and UDVA), spherical equivalent (SE), endothelial cell density (ECD), central cornea thickness (CCT) and depth of demarcation line (DDL) were Meta-analyzed as secondary outcomes...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28944092/mefa-multiepitope-fusion-antigen-novel-technology-for-structural-vaccinology-proof-from-computational-and-empirical-immunogenicity-characterization-of-an-enterotoxigenic-escherichia-coli-etec-adhesin-mefa
#15
Qiangde Duan, Kuo Hao Lee, Rahul M Nandre, Carolina Garcia, Jianhan Chen, Weiping Zhang
Vaccine development often encounters the challenge of virulence heterogeneity. Enterotoxigenic Escherichia coli (ETEC) bacteria producing immunologically heterogeneous virulence factors are a leading cause of children's diarrhea and travelers' diarrhea. Currently, we do not have licensed vaccines against ETEC bacteria. While conventional methods continue to make progress but encounter challenge, new computational and structure-based approaches are explored to accelerate ETEC vaccine development. In this study, we applied a structural vaccinology concept to construct a structure-based multiepitope fusion antigen (MEFA) to carry representing epitopes of the seven most important ETEC adhesins [CFA/I, CFA/II (CS1-CS3), CFA/IV (CS4-CS6)], simulated antigenic structure of the CFA/I/II/IV MEFA with computational atomistic modeling and simulation, characterized immunogenicity in mouse immunization, and examined the potential of structure-informed vaccine design for ETEC vaccine development...
August 2017: Journal of Vaccines & Vaccination
https://www.readbyqxmd.com/read/28944079/quantitative-systems-biology-to-decipher-design-principles-of-a-dynamic-cell-cycle-network-the-maximum-allowable-mammalian-trade-off-weight-mamtow
#16
REVIEW
Matteo Barberis, Paul Verbruggen
Network complexity is required to lend cellular processes flexibility to respond timely to a variety of dynamic signals, while simultaneously warranting robustness to protect cellular integrity against perturbations. The cell cycle serves as a paradigm for such processes; it maintains its frequency and temporal structure (although these may differ among cell types) under the former, but accelerates under the latter. Cell cycle molecules act together in time and in different cellular compartments to execute cell type-specific programs...
2017: NPJ Systems Biology and Applications
https://www.readbyqxmd.com/read/28943949/sitagliptin-a-dipeptidyl-peptidase-4-inhibitor-suppresses-cxcl5-and-sdf-1-and-does-not-accelerate-intestinal-neoplasia-formation-in-apc-min-mice-fed-a-high-fat-diet
#17
Kaori Fujiwara, Takuya Inoue, Yujiro Henmi, Yoshimasa Hirata, Yutaka Naka, Azusa Hara, Kazuki Kakimoto, Sadaharu Nouda, Toshihiko Okada, Ken Kawakami, Toshihisa Takeuchi, Kazuhide Higuchi
The relationship between type 2 diabetes mellitus and intestinal neoplasia has been shown epidemiologically. A high-fat diet (HFD) is also known to promote insulin resistance, which is a risk factor for intestinal neoplasia. Dipeptidyl peptidase-4 (DPP-4) inhibitors are used in the clinic for the treatment of type 2 diabetes and also to prolong the effects of glucagon-like peptide-1 (GLP-1). However, since the intestinotrophic hormone GLP-2 and chemokines, such as CXCL5 and stromal cell-derived factor-1 (SDF-1), are also substrates of DPP-4, DPP-4 inhibitors may increase the risk of intestinal carcinogenesis...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943922/obesity-accelerates-murine-gastric-cancer-growth-by-modulating-the-sirt1-yap-pathway
#18
Hai-Jun Li, Jun-Ke Fu, Xiang-Ming Che, Lin Fan, Yong Zhang, E Bai
A previous study from our group using an in vivo model demonstrated that diet induced-obesity increases the risk of gastric cancer and may prompt its growth. However, the molecular mechanisms underlying this association remain unclear and require further investigation. The aim of the present study was to investigate the potential molecular mechanisms through which obesity affects gastric cancer growth. In a subcutaneous mouse model, tumors were significantly larger in obese mice compared with non-obese and lean mice...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943853/arginase-ii-deficiency-extends-lifespan-in-mice
#19
Yuyan Xiong, Gautham Yepuri, Jean-Pierre Montani, Xiu-Fen Ming, Zhihong Yang
The mitochondrial arginase type II (Arg-II) has been shown to interact with ribosomal protein S6 kinase 1 (S6K1) and mitochondrial p66(Shc) and to promote cell senescence, apoptosis and inflammation under pathological conditions. However, the impact of Arg-II on organismal lifespan is not known. In this study, we demonstrate a significant lifespan extension in mice with Arg-II gene deficiency (Arg-II(-/-)) as compared to wild type (WT) control animals. This effect is more pronounced in the females than in the males...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28943718/a-branch-and-bound-framework-for-unsupervised-common-event-discovery
#20
Wen-Sheng Chu, Fernando De la Torre, Jeffrey F Cohn, Daniel S Messinger
Event discovery aims to discover a temporal segment of interest, such as human behavior, actions or activities. Most approaches to event discovery within or between time series use supervised learning. This becomes problematic when some relevant event labels are unknown, are difficult to detect, or not all possible combinations of events have been anticipated. To overcome these problems, this paper explores Common Event Discovery (CED), a new problem that aims to discover common events of variable-length segments in an unsupervised manner...
July 2017: International Journal of Computer Vision
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