Jan-Rüdiger Schüre, Stefano Casagranda, Maria Sedykh, Patrick Liebig, Christos Papageorgakis, Laura Mancini, Sotirios Bisdas, Lucia Nichelli, Nandor Pinter, Laszlo Mechtler, Ramin Jafari, Nathalie Boddaert, Volodia Dangouloff-Ros, Julie Poujol, Manuel Schmidt, Arnd Doerfler, Moritz Zaiss
PURPOSE: Amide proton transfer-weighted (APTw) MRI at 3T provides a unique contrast for brain tumor imaging. However, APTw imaging suffers from hyperintensities in liquid compartments such as cystic or necrotic structures and provides a distorted APTw signal intensity. Recently, it has been shown that heuristically motivated fluid suppression can remove such artifacts and significantly improve the readability of APTw imaging. THEORY AND METHODS: In this work, we show that the fluid suppression can actually be understood by the known concept of spillover dilution, which itself can be derived from the Bloch-McConnell equations in comparison to the heuristic approach...
December 10, 2023: Magnetic Resonance in Medicine