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https://www.readbyqxmd.com/read/29787037/effects-of-perinatal-exposure-to-dibutyltin-chloride-on-fat-and-glucose-metabolism-in-mice-and-molecular-mechanisms-in-vitro
#1
Raquel Chamorro-García, Bassem M Shoucri, Sigal Willner, Heidi Käch, Amanda Janesick, Bruce Blumberg
BACKGROUND: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, in construction materials, and in medical devices. Previous animal studies showed detrimental effects of DBT during in utero development at relatively high doses, but little was known about the effects of DBT exposure at environmentally relevant doses on endpoints such as obesity and metabolic disease. OBJECTIVES: We tested the potential obesogenic effects of DBT using in vitro and in vivo models...
May 2018: Environmental Health Perspectives
https://www.readbyqxmd.com/read/29786943/integrating-a-comprehensive-dna-barcode-reference-library-with-a-global-map-of-yews-taxus-l-for-forensic-identification
#2
Jie Liu, Richard I Milne, Michael Möller, Guang-Fu Zhu, Lin-Jiang Ye, Ya-Huang Luo, Jun-Bo Yang, Moses Cheloti Wambulwa, Chun-Neng Wang, De-Zhu Li, Lian-Ming Gao
Rapid and accurate identification of endangered species is a critical component of bio-surveillance and conservation management, and potentially policing illegal trades. However, this is often not possible using traditional taxonomy, especially where only small or pre-processed parts of plants are available. Reliable identification can be achieved via a comprehensive DNA barcode reference library, accompanied by precise distribution data. However, these require extensive sampling at spatial and taxonomic scales, which has rarely been achieved for cosmopolitan taxa...
May 22, 2018: Molecular Ecology Resources
https://www.readbyqxmd.com/read/29786931/real-time-monitoring-of-prodrug-activation-by-direct-mode-of-chemiluminescence
#3
Doron Shabat, Samer Gnaim, Anna Scomparin, Sayantan Das, Ronit Satchi-Fainaro
The majority of theranostic prodrugs reported so far relay information through a fluorogenic response generated upon release of the active chemotherapeutic agent. A chemiluminescence detection mode offers significant advantages over fluorescence, mainly due to the superior signal-to-noise ratio of chemiluminescence. Here we report the design and synthesis of the first theranostic prodrug monitored by a chemiluminescence diagnostic mode. As a representative model we prepared a prodrug from the chemotherapeutic monomethyl auristatin E designed for activation by β-galactosidase...
May 22, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29786896/diagnostic-accuracy-of-bioelectrical-impedance-analysis-parameters-for-the-evaluation-of-malnutrition-in-patients-receiving-hemodialysis
#4
Angela Teodósio da Silva, Daniela Barbieri Hauschild, Yara Maria Franco Moreno, João Luiz Dornelles Bastos, Elisabeth Wazlawik
BACKGROUND: In the absence of a gold standard technique for assessing nutrition status in patients receiving hemodialysis (HD), we aimed to determine the diagnostic accuracy of single-frequency (50 kHz) bioelectrical impedance analysis parameters, resistance/height (R/H), reactance/height (Xc/H), and impedance/height (Z/H), and their cutoff points for malnutrition. METHODS: The reference standards, Subjective Global Assessment (SGA), Malnutrition Inflammation Score, and Nutritional Risk Screening 2002, were performed at baseline and then once a year for 2 years...
May 22, 2018: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29786829/meta-analysis-examining-the-epidemiology-of-clozapine-associated-neutropenia
#5
N Myles, H Myles, S Xia, M Large, S Kisely, C Galletly, R Bird, D Siskind
BACKGROUND: Clozapine is associated with life-threatening neutropenia. There are no previous meta-analyses of the epidemiology of clozapine-associated neutropenia. OBJECTIVES: To determine the cumulative incidence of mild, moderate and severe neutropenia, incidence of death related to severe neutropenia, case fatality rate of neutropenia and the longitudinal incidence of neutropenia following exposure to clozapine. DATA SOURCES: A systematic search of Medline, EMBASE and PsycINFO using search terms [clozapine OR clopine OR zaponex OR clozaril] AND [neutropenia OR agranulocytosis]...
May 21, 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/29786813/prediction-of-mortality-in-pediatric-traumatic-brain-injury-implementations-from-a-tertiary-pediatric-intensive-care-facility
#6
Ebru Atike Ongun, Oğuz Dursun
BACKGROUND: To explore the mortality risk factors of traumatic brain injury in pediatric intensive care unit admissions. METHODS: Eighty-eight children (categorized using the Glasgow Coma Scale) between September 2014 and December 2016 were analyzed. Emergency department and intensive care course, treatment strategies, axonal injury, intubation and tracheostomy rates, length of intensive care and hospitalization, Rotterdam-CT scores, injury severity scores, and PRISM-III scores were recorded...
May 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29786802/-treatment-with-neurostimulation-and-ketogenic-diet-for-people-with-medically-refractory-epilepsy
#7
Eva Kumlien, Tove Hallbook, Maria Dahlin
For some people with medically refractory epilepsy adjunct treatment with neurostimulation and ketogenic diet can be an option. Vagal nerve stimulation, VNS, consists of chronic intermittent electrical stimulation of the vagus nerve. VNS is effective and well tolerated in adolescents and adults. There is insufficient evidence on the efficacy of deep brain stimulation, DBS, and brain-responsive neurostimulation, RNS. Ketogenic diet is an established treatment in epilepsy with an increased number of indications, especially in neurometabolic diseases, where dietary therapy can completely eliminate epilepsy and improve cognitive and motor development...
May 22, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29786742/a-novel-alendronate-functionalized-nanoprobe-for-simple-colorimetric-detection-of-cancer-associated-hypercalcemia
#8
Abhishek Sahu, Youngmin Hwang, Cristian Vilos, Jong-Min Lim, Sunghyun Kim, Won Il Choi, Giyoong Tae
The calcium (Ca2+) ion concentration in the blood serum is tightly regulated, and any abnormalities in the level of serum calcium ions are associated with many potentially dangerous diseases. Thus, monitoring of the Ca2+ ion concentration in the blood serum is of fundamental importance. Gold nanoparticle (GNP)-based colorimetric biosensors have enormous potential in clinical diagnostic applications due to their simplicity, versatility, and unique optical properties. In this study, we have developed an alendronate functionalized gold nanoparticle (GNP-ALD) system for the measurement of Ca2+ ion concentration in biological samples...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786727/rational-design-of-multi-functional-gold-nanoparticles-with-controlled-biomolecule-adsorption-a-multi-method-approach-for-in-depth-characterization
#9
Isaac Ojea-Jiménez, Robin Capomaccio, Inês Osório, Dora Mehn, Giacomo Ceccone, Rohanah Hussain, Giuliano Siligardi, Pascal Colpo, François Rossi, Douglas Gilliland, Luigi Calzolai
Multi-functionalized nanoparticles are of great interest in biotechnology and biomedicine, especially for diagnostic and therapeutic purposes. However, at the moment the characterization of complex, multi-functional nanoparticles is still challenging and this hampers the development of advanced nanomaterials for biological applications. In this work, we have designed a model system consisting of gold nanoparticles functionalized with two differentially-terminated poly(ethylene oxide) ligands, providing both "stealth" properties and protein-binding capabilities to the nanoparticles...
May 22, 2018: Nanoscale
https://www.readbyqxmd.com/read/29786719/energy-transfer-chemiluminescence-for-ratiometric-ph-imaging
#10
Weiwei An, Ralph P Mason, Alexander R Lippert
Chemiluminescence imaging offers a low background and high sensitivity approach to imaging analytes in living cells and animals. Intensity-based measurements have been developed, but require careful consideration of kinetics, probe localization, and fluctuations in quantum yield, all of which complicate quantification. Here, we report a ratiometric strategy for quantitative chemiluminescence imaging of pH. The strategy relies on an energy transfer cascade of chemiluminescence emission from a spiroadamantane 1,2-dioxetane to a ratiometric pH indicator via fluorescent dyes in Enhancer solutions...
May 22, 2018: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/29786706/hg-ii-interactions-with-t-rich-regions-in-oligonucleotides-effects-of-positional-variations-on-the-electrochemical-properties
#11
Ajar Kamal, Renu Sharma, Zhe She, Heinz-Bernhard Kraatz
Hg(ii) binding to thymine-rich oligonucleotides (ODNs) is investigated electrochemically. The focus of this study is to probe the effects of position on the electrochemical response. For this purpose, three oligonucleotides were investigated in which the position of a hexa-thymine repeat is varied within a surface-supported oligonucleotide. The hexa repeats were placed in the top, middle, and bottom positions within the strand with respect to the gold surface. The effects were monitored by electrochemical impedance spectroscopy and scanning electrochemical microscopy...
May 22, 2018: Analyst
https://www.readbyqxmd.com/read/29786704/peri-implant-tissue-score-pits-as-a-measure-of-success-applied-to-869-dental-implants-from-a-retrospective-clinical-study
#12
Zbyněk Mazur, Ladislav Korábek, Daniel Mazur
OBJECTIVE: This article presents a methodology of a comprehensive score for assessment and monitoring of dental implant success from the peri-implant tissue perspective. It involves only standard and minimally invasive techniques accessible to general dental practices, without the need for special equipment. METHODS AND MATERIALS: The proposed score methodology combines existing consensual global knowledge regarding aspects of dental implant success with the standard examination tools accepted for regular recall assessment...
May 17, 2018: Quintessence International
https://www.readbyqxmd.com/read/29786680/-the-comprehensive-evaluation-of-the-bioclimatic-comfort-at-the-territories-of-the-russian-far-east-with-reference-to-winter-time-recreational-activities-and-primary-wellness-tourism
#13
N M Pestereva, A F Khechumyan, N Vorozbit
BACKGROUND: in the framework of the current tendency toward the further development of the socio-economic sphere in the Russian Far East (RFE), the relevant investigations aimed at creating the comfortable conditions for recreational and touristic activities as well as for rehabilitative therapy of the local population acquire the increasingly greater importance. AIM: The objective of the present study was the comprehensive evaluation of the bioclimatic comfort at the territories of interest with special reference to winter-time recreational activities and primary wellness tourism...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786677/-combined-rehabilitation-in-the-patients-presenting-with-dorsopathies-of-the-lumbar-spine-and-concomitant-irritable-bowel-syndrome-based-at-a-therapeutic-clinic
#14
E V Sevostyanova, Y A Nikolaev, N V Bogdankevich, V G Lusheva, N A Dolgova, V Y Polyakov
BACKGROUND: Comorbidity constitutes a serious challenge for rehabilitative medicine. The comorbidity of the dorsopathy of the lumbar spine and irritable bowel syndrome mutually complicates the clinical course of both conditions, significantly reduces the patients' quality of life. and increases the costs of diagnostic procedures and restoration of the working capacity. The approaches to the non-pharmacological management of the patients presenting with these diseases remain to be developed...
May 21, 2018: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/29786626/observation-of-women-soccer-players-physiology-during-a-single-season
#15
Kathleen M Paulsen, Cory L Butts, Brendon P McDermott
Paulsen, KM, Butts, CL, and McDermott, BP. Observation of women soccer players' physiology during a single season. J Strength Cond Res 32(6): 1702-1707, 2018-The purpose of this study was to observe heart rate (HR) responses in match settings over the course of a conference season in National Collegiate Athletic Association Division I women's soccer. Twenty-one female collegiate soccer players were provided a HR monitor and instructed to wear it for the duration of match play. Player positions included 6 defenders (DEF), 6 midfielders (MID), and 9 forwards (FWD)...
June 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29786581/development-of-informational-communicative-system-created-to-improve-medical-help-for-family-medicine-doctors
#16
Vladyslav A Smiianov, Natalia O Dryha, Olha I Smiianova, Victor K Obodyak, Tatyana O Zudina
OBJECTIVE: Introduction: Today mobile health`s protection service has no concrete meaning. As an research object it was called mHealth and named by Global observatory of electronic health`s protection as "Doctor and social health practice that can be supported by any mobile units (mobile phones or smartphones), units for patient`s health control, personal computers and other units of non-wired communication". An active usage of SMS in programs for patients` cure regimen keeping was quiet predictable...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786580/-iron-deficiency-reduces-systemic-inflammation-in-obese-women
#17
Vadim M Nedoborenko, Anna V Lavrenko, Tatyana V Mamontova, Lyudmyla E Vesnina, Igor P Kaidashev
OBJECTIVE: Introduction: Iron plays an important role in the functioning of immunological monitoring due to its stimulating and differentiating effect on the immune system. Obesity is accompanied by chronic low grade inflammation and may be accompanied by a change in the concentration of iron in the blood serum. The aim of the study was to determine the level of systemic inflammation in iron deficiency anemia in patients with obesity. PATIENTS AND METHODS: Materials and methods: 40 women with iron deficiency anemia (30 with obesity and 10 without obesity) and 10 with obesity of a similar age (control group) participated in the study...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29786561/impedance-based-cellular-assays-for-regenerative-medicine
#18
REVIEW
W Gamal, H Wu, I Underwood, J Jia, S Smith, P O Bagnaninchi
Therapies based on regenerative techniques have the potential to radically improve healthcare in the coming years. As a result, there is an emerging need for non-destructive and label-free technologies to assess the quality of engineered tissues and cell-based products prior to their use in the clinic. In parallel, the emerging regenerative medicine industry that aims to produce stem cells and their progeny on a large scale will benefit from moving away from existing destructive biochemical assays towards data-driven automation and control at the industrial scale...
July 5, 2018: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/29786523/decision-support-beyond-total-savings-eligibility-and-potential-savings-for-individual-participants-from-changes-in-the-national-surveillance-strategy-for-bovine-viral-diarrhoea-bvd-in-ireland
#19
Jamie A Tratalos, Hans-Hermann Thulke, David A Graham, Maria Guelbenzu Gonzalo, Simon J More
Surveillance and management of livestock diseases is often evaluated with reference to expected sector-wide costs. In contrast, we calculate losses or savings for individual herd owners of a change in monitoring strategy during a national cattle disease eradication programme: bovine viral diarrhoea (BVD) in Ireland. The alternative strategy differs in how the disease is identified; by its sample- rather than census-based approach; and by its greater cost per test. We examined the costs faced by each breeding herd if testing were conducted using serology on a sample of young stock, in contrast to the current method of tissue-tag testing of all newborn calves...
July 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29786520/impact-of-piglet-oral-vaccination-against-tuberculosis-in-endemic-free-ranging-wild-boar-populations
#20
Iratxe Díez-Delgado, Iker A Sevilla, Beatriz Romero, Eleanor Tanner, Jose A Barasona, Andrew R White, Peter W W Lurz, Mike Boots, José de la Fuente, Lucas Dominguez, Joaquin Vicente, Joseba M Garrido, Ramón A Juste, Alicia Aranaz, Christian Gortazar
The Eurasian wild boar (Sus scrofa) is the main wild reservoir of the Mycobacterium tuberculosis complex in Mediterranean woodlands and a key risk factor for cattle tuberculosis (TB) breakdowns. Wild boar vaccination therefore has the potential to be a valuable tool for TB control. We tested two orally delivered vaccines, heat-inactivated Mycobacterium bovis (IV) and BCG, in four sites (two per vaccine type: one Managed and one Natural or unmanaged) during four years. TB was also monitored in 15 unvaccinated sites (spatial control), as well as in all sites from one year prior to intervention (temporal control)...
July 1, 2018: Preventive Veterinary Medicine
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