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Cerebral palsy treatment

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https://www.readbyqxmd.com/read/29774532/the-fetus-at-the-tipping-point-modifying-the-outcome-of-fetal-asphyxia
#1
Simerdeep K Dhillon, Christopher A Lear, Robert Galinsky, Guido Wassink, Joanne O Davidson, Sandra Juul, Nicola J Robertson, Alistair J Gunn, Laura Bennet
Brain injury around birth is associated with nearly half of all cases of cerebral palsy. Although brain injury is multifactorial, particularly after preterm birth, acute hypoxia-ischaemia is a major contributor to injury. It is now well established that the severity of injury after HI is determined by a dynamic balance between injurious and protective processes. In addition, mothers who are at risk of premature delivery have high rates of diabetes and antepartum infection/inflammation and are almost universally given treatments such as antenatal glucocorticoids and magnesium sulphate to reduce the risk of death and complications after preterm birth...
May 17, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29772695/botulinum-toxin-type-a-injection-for-cervical-dystonia-in-adults-with-dyskinetic-cerebral-palsy
#2
You Gyoung Yi, Keewon Kim, Youbin Yi, Young-Ah Choi, Ja-Ho Leigh, Moon Suk Bang
We aimed to evaluate the efficacy and safety of injecting botulinum toxin A (BoNT-A) into the neck muscles to treat cervical dystonia (CD) in patients with dyskinetic cerebral palsy (CP). This was a randomized, double-blinded, placebo-controlled trial with cross-over design. We prospectively enrolled adults with dyskinetic CP who were over 20 years old and had been clinically diagnosed with CD for more than one year. The primary outcome measure was the change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) at four weeks from the baseline TWSTRS...
May 16, 2018: Toxins
https://www.readbyqxmd.com/read/29769256/early-use-of-antibiotics-for-at-risk-children-with-influenza-archie-protocol-for-a-double-blind-randomised-placebo-controlled-trial
#3
Kay Wang, Tricia Carver, Sharon Tonner, Malcolm G Semple, Alastair D Hay, Michael Moore, Paul Little, Christopher Butler, Andrew Farmer, Rafael Perera, Ly-Mee Yu, Susan Mallett, Jane Wolstenholme, Anthony Harnden
INTRODUCTION: Influenza and influenza-like illness (ILI) create considerable burden on healthcare resources each winter. Children with pre-existing conditions such as asthma, diabetes mellitus and cerebral palsy are among those at greatest risk of clinical deterioration from influenza/ILI. The Antibiotics for at Risk CHildren with InfluEnza (ARCHIE) trial aims to determine whether early oral treatment with the antibiotic co-amoxiclav reduces the likelihood of reconsultation due to clinical deterioration in these 'at risk' children...
May 16, 2018: BMJ Open
https://www.readbyqxmd.com/read/29768338/botulinum-toxin-injection-to-improve-functional-independence-and-to-alleviate-parenting-stress-in-a-child-with-advanced-pantothenate-kinase-associated-neurodegeneration-a-case-report-and-literature-review
#4
Cho-I Lin, Kuan-Lin Chen, Ta-Shen Kuan, Sheng-Han Lin, Wei-Pin Lin, Yu-Ching Lin
RATIONALE: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare autosomal recessive disease. Progressive motor symptoms such as dystonia and spasticity begin in childhood and relentlessly become incapacitating later in life. Treatments including anticholinergics and iron chelation are usually ineffective. Botulinum toxin type A (BoNT-A) is effective for adult patients with dystonia or spasticity. PATIENT CONCERNS: We reported a 10-year-old female patient with advanced PKAN, manifesting as generalized dystonia and spasticity...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29764710/a-systematic-review-to-explore-the-feasibility-of-a-behavioural-sleep-intervention-for-insomnia-in-children-with-neurodevelopmental-disorders-a-transdiagnostic-approach
#5
REVIEW
Gabrielle Rigney, Nicole S Ali, Penny V Corkum, Cary A Brown, Evelyn Constantin, Roger Godbout, Ana Hanlon-Dearman, Osman Ipsiroglu, Graham J Reid, Sarah Shea, Isabel M Smith, Hendrik F M Van der Loos, Shelly K Weiss
Children with neurodevelopmental disorders (NDD) are at high risk for sleep problems, especially insomnia. It is currently not known whether behavioural sleep interventions developed for typically developing (TD) children are effective for children with NDD, and if interventions need to be modified for each diagnostic group. The aim of this systematic review was to identify and evaluate commonalities, trends in outcomes, and the methodological quality of parent-delivered behavioural sleep interventions for children with NDD, specifically Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), Cerebral Palsy, and Fetal Alcohol Spectrum Disorder...
March 31, 2018: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/29763510/trihexyphenidyl-for-dystonia-in-cerebral-palsy
#6
REVIEW
Adrienne R Harvey, Louise B Baker, Dinah Susan Reddihough, Adam Scheinberg, Katrina Williams
BACKGROUND: Cerebral palsy occurs in up to 2.1 of every 1000 live births and encompasses a range of motor problems and movement disorders. One commonly occurring movement disorder amongst those with cerebral palsy is dystonia: sustained or intermittent involuntary muscle spasms and contractions that cause twisting, repetitive movements and abnormal postures. The involuntary contractions are often very painful and distressing and cause significant limitations to activity and participation...
May 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29762118/pediatric-orthopaedic-consults-from-chiropractic-care
#7
Andy B Awwad, William L Hennrikus, Douglas G Armstrong
Alternative medicine in pediatrics is expanding, with chiropractic now a common choice for families seeking alternative medical care. Currently, there is sparse information in the literature exploring the role of chiropractic in orthopaedic pathology. The objective of this case series is to present pediatric patients who received treatment from chiropractors and orthopaedic physicians as well as to review the respective existing research. Data collected included chiropractic diagnosis, orthopaedic diagnosis, imaging studies, treatments, and complications...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29759883/minimally-invasive-plate-osteosynthesis-for-tibial-derotation-osteotomies-in-children-with-cerebral-palsy
#8
Ilker Abdullah Sarikaya, Ali Seker, Ozan Ali Erdal, Mehmet Ali Talmac, Muharrem Inan
OBJECTIVE: Tibial derotation osteotomy can be used in the treatment of rotational deformities in case of ineffective conservative management. Our aim was to evaluate the results of the patients who underwent minimal invasive plate osteosynthesis for tibial derotation osteotomies. METHODS: Total of 16 patients (17 procedures) were included in this study. Mean age was 11.5 (3-25) years. We clinically assessed the tibial torsion by measuring the thigh-foot angle (TFA)...
May 11, 2018: Acta Orthopaedica et Traumatologica Turcica
https://www.readbyqxmd.com/read/29753172/the-increase-of-anterior-pelvic-tilt-after-crouch-gait-treatment-in-patients-with-cerebral-palsy
#9
Mauro César de Morais Filho, Francesco Camara Blumetti, Cátia Miyuki Kawamura, Jaqueline Bartelega Rodrigues Leite, José Augusto Fernandes Lopes, Marcelo Hideki Fujino, Daniella Lins Neves
BACKGROUND: The increase of anterior pelvic tilt (APT) has been described after the treatment of crouch gait in cerebral palsy (CP). The ideal treatment option for flexed knee gait in CP should provide knee extension improvement in the stance phase without generating the increase of APT. RESEARCH QUESTION: The purpose of this study was to compare three different approaches used for the treatment of crouch gait in CP [distal femur extension osteotomy (DFEO), patellar tendon shortening (PTS) and the combination of DFEO +PTS] regarding the increase of APT after the interventions...
May 5, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29739443/cognition-and-bimanual-performance-in-children-with-unilateral-cerebral-palsy-protocol-for-a-multicentre-cross-sectional-study
#10
Brian Hoare, Michael Ditchfield, Megan Thorley, Margaret Wallen, Jenny Bracken, Adrienne Harvey, Catherine Elliott, Iona Novak, Ali Crichton
BACKGROUND: Motor outcomes of children with unilateral cerebral palsy are clearly documented and well understood, yet few studies describe the cognitive functioning in this population, and the associations between the two is poorly understood. Using two hands together in daily life involves complex motor and cognitive processes. Impairment in either domain may contribute to difficulties with bimanual performance. Research is yet to derive whether, and how, cognition affects a child's ability to use their two hands to perform bimanual tasks...
May 8, 2018: BMC Neurology
https://www.readbyqxmd.com/read/29733439/proximal-versus-distal-femoral-derotation-osteotomy-in-bilateral-cerebral-palsy
#11
Mirjam Niklasch, Elizabeth R Boyer, Tom Novacheck, Thomas Dreher, Michael Schwartz
AIM: Femoral derotation osteotomy (FDO) can be conducted either proximally or distally to correct internal rotation gait (IRG) and increased anteversion in children with cerebral palsy (CP). Previous studies with limited numbers of participants have presented comparable short-term static and kinematic outcomes for both techniques. The objective of this retrospective multicentre study was to verify this thesis with a larger number of patients. METHOD: In total, 119 children with CP and IRG were included after matching the groups on preoperative mean stance hip rotation: 67 intertrochanteric (proximal group) FDO (average age at surgery 9y [SD 3y]); 52 supracondylar (distal group) FDO (average age at surgery 12y [SD 3y])...
May 7, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29730660/perinatal-outcome-and-long-term-neurodevelopment-after-intracranial-haemorrhage-due-to-fetal-and-neonatal-alloimmune-thrombocytopenia
#12
Dian Winkelhorst, Marije M Kamphuis, Sylke J Steggerda, Monique Rijken, Dick Oepkes, Enrico Lopriore, Jeanine M M van Klink
OBJECTIVES: To evaluate the perinatal and long-term neurodevelopmental outcome in a cohort of children with intracranial haemorrhage (ICH) due to fetal and neonatal alloimmune thrombocytopenia (FNAIT) and to clearly outline the burden of this disease. SUBJECTS AND METHODS: We performed an observational cohort study and included all consecutive cases of ICH caused by FNAIT from 1993 to 2015 at Leiden University Medical Centre. Neurological, motor, and cognitive development were assessed at a minimum age of 1 year...
May 4, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29720544/advantages-of-virtual-reality-in-the-rehabilitation-of-balance-and-gait-systematic-review
#13
REVIEW
Desiderio Cano Porras, Petra Siemonsma, Rivka Inzelberg, Gabriel Zeilig, Meir Plotnik
BACKGROUND: Virtual reality (VR) has emerged as a therapeutic tool facilitating motor learning for balance and gait rehabilitation. The evidence, however, has not yet resulted in standardized guidelines. The aim of this study was to systematically review the application of VR-based rehabilitation of balance and gait in 6 neurologic cohorts, describing methodologic quality, intervention programs, and reported efficacy. METHODS: This study follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
May 2, 2018: Neurology
https://www.readbyqxmd.com/read/29718808/differences-in-lumbar-motor-neuron-pruning-in-an-animal-model-of-early-onset-spasticity
#14
Joline E Brandenburg, Heather M Gransee, Matthew J Fogarty, Gary C Sieck
Motor neuron (MN) development in early onset spasticity is poorly understood. For example, spastic cerebral palsy (sCP), the most common motor disability of childhood, is poorly predicted by brain imaging, yet research remains focused on the brain. By contrast, MNs, via the motor unit and neurotransmitter signaling, are the target of most therapeutic spasticity treatments and are the final common output of motor control. MN development in sCP is a critical knowledge gap as the late embryonic and postnatal periods are not only when the supposed brain injury occurs, but are critical times for spinal cord neuromotor development...
May 2, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29710760/effects-of-live-and-video-form-action-observation-training-on-upper-limb-function-in-children-with-hemiparetic-cerebral-palsy
#15
Do Hyun Kim, Duk-Hyun An, Won-Gyu Yoo
PURPOSE: The purpose of this study was to investigate the effects of live and video form action observation training (AOT) on upper limb (UL) movement acceleration and function in children with cerebral palsy (CP). METHODS: In total, 12 children (7 boys, 5 girls) with CP participated in this study. The children were allocated randomly to live (experimental) and video (control) AOT groups. All children completed 20 treatment sessions, each 30 minutes in duration, 5 days per week for a month...
April 20, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29708908/anteverting-bernese-periacetabular-osteotomy-in-the-treatment-of-neurogenic-hip-dysplasia-in-cerebral-palsy
#16
Andrew G Georgiadis, Vivek Dutt, Walter H Truong, Susan A Novotny, Tom F Novacheck
All patients with hypertonic cerebral palsy undergoing Bernese periacetabular osteotomy (PAO) between 2005 and 2014 were reviewed. Clinical and radiographic parameters, including the cerebral palsy hip classification and anterior and posterior wall indices were collected to assess acetabular reorientation. Twenty (83%) of 24 procedures involved the correction of posterolateral acetabular insufficiency and were 'anteverting PAOs'. All 20 experienced improvements in radiographic indices. Eleven (58%) of 19 PAOs in ambulatory patients were performed in the setting of other multilevel orthopedic surgery...
April 27, 2018: Journal of Pediatric Orthopedics. Part B
https://www.readbyqxmd.com/read/29707053/reliability-and-efficiency-of-three-methods-of-calculating-migration-percentage-on-radiographs-for-hip-surveillance-in-children-with-cerebral-palsy
#17
V A Kulkarni, J R Davids, A D Boyles, N Q Cung, A Bagley
Purpose: Hip surveillance programmes for children with cerebral palsy (CP) utilize the migration percentage (MP) measurement to initiate referrals and recommend treatment. This study assesses the reliability and efficiency of three methods of MP measurement on anteroposterior (AP) pelvis radiographs. Methods: A total of 20 AP pelvis radiographs (40 hips) of children with CP were measured by three raters on two occasions using three methods: digital measurement (DM) on a Picture Archiving and Communication System monitor, computer-aided measurement (CA) using a digital templating tool and mobile device application measurement (MA) using a freely available MP measurement tool...
April 1, 2018: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/29706928/repetitive-neonatal-erythropoietin-and-melatonin-combinatorial-treatment-provides-sustained-repair-of-functional-deficits-in-a-rat-model-of-cerebral-palsy
#18
Lauren L Jantzie, Akosua Y Oppong, Fatu S Conteh, Tracylyn R Yellowhair, Joshua Kim, Gabrielle Fink, Adam R Wolin, Frances J Northington, Shenandoah Robinson
Cerebral palsy (CP) is the leading cause of motor impairment for children worldwide and results from perinatal brain injury (PBI). To test novel therapeutics to mitigate deficits from PBI, we developed a rat model of extreme preterm birth (<28 weeks of gestation) that mimics dual intrauterine injury from placental underperfusion and chorioamnionitis. We hypothesized that a sustained postnatal treatment regimen that combines the endogenous neuroreparative agents erythropoietin (EPO) and melatonin (MLT) would mitigate molecular, sensorimotor, and cognitive abnormalities in adults rats following prenatal injury...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29705462/opinions-and-observations-of-caregivers-of-children-with-cerebral-palsy-about-changes-seen-after-reflexology-a-qualitative-study
#19
Filiz Özkan, Handan Zincir
The aim of this research was to examine the effect of reflexology on the problems of children with cerebral palsy from perspective of caregivers. Qualitative study was made after 24-session reflexology program. 12 caregivers who have 2-18 year-old children with spastic type cerebral palsy receiving special education and received reflexology. The thematic questions were determined and in-depth interviews were conducted. Themes of the study were determined as; the caregiver's views on reflexology, the effect of reflexology on health of children with CP and the caregivers' observations on child after reflexology therapy, positive and negative aspects and causes of reflexology treatment...
May 2018: Complementary Therapies in Clinical Practice
https://www.readbyqxmd.com/read/29705454/effects-of-a-hippotherapy-intervention-on-muscle-spasticity-in-children-with-cerebral-palsy-a-randomized-controlled-trial
#20
David Lucena-Antón, Ignacio Rosety-Rodríguez, Jose A Moral-Munoz
OBJECTIVE: The aim of the present study is to evaluate the effect of a 12 weeks hippotherapy intervention protocol on hip adductors spasticity in children with spastic cerebral palsy. DESIGN: Randomized controlled trial. SETTINGS/LOCATION: The intervention was conducted in an Equestrian and Therapeutic Association. Patients were recruited from a Rehabilitation Unit of Cerebral Palsy. SUBJECTS: A total of 44 children with spastic cerebral palsy (Gross Motor Function Classification System [GMFCS] levels IV-V; 28 boys and 16 girls; aged 8 years 10 months, SD 3 months) were assigned to a treatment (n = 22; mean age 9 years 6 months, SD 3 months) or a control group (n = 22; mean age 8 years 3 months, SD 3 months)...
May 2018: Complementary Therapies in Clinical Practice
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