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Cerebral palsy treatment

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https://www.readbyqxmd.com/read/28915908/advances-in-paediatrics-in-2016-current-practices-and-challenges-in-allergy-autoimmune-diseases-cardiology-endocrinology-gastroenterology-infectious-diseases-neonatology-nephrology-neurology-nutrition-pulmonology
#1
REVIEW
Carlo Caffarelli, Francesca Santamaria, Dora Di Mauro, Carla Mastrorilli, Silvia Montella, Sergio Bernasconi
This review reports main progresses in various pediatric issues published in Italian Journal of Pediatrics and in international journals in 2016. New insights in clinical features or complications of several disorders may be useful for our better understanding. They comprise severe asthma, changing features of lupus erythematosus from birth to adolescence, celiac disease, functional gastrointestinal disorders, Moebius syndrome, recurrent pneumonia. Risk factors for congenital heart defects, Kawasaki disease have been widely investigated...
September 16, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28914131/safety-and-efficacy-of-repeat-open-label-abobotulinumtoxina-treatment-in-pediatric-cerebral-palsy
#2
Mauricio R Delgado, Marcin Bonikowski, Jorge Carranza, Edward Dabrowski, Dennis Matthews, Barry Russman, Ann Tilton, Juan Carlos Velez, Anne-Sophie Grandoulier, Philippe Picaut
This was a prospective, repeat-treatment, open-label study (NCT01251380) of abobotulinumtoxinA for the management of lower limb spasticity in children who had completed a double-blind study. Children (2-17 years) received injections into the gastrocnemius-soleus complex, and other distal and proximal muscles as required (maximum total dose per injection cycle: 30 U/kg or 1000U). A total of 216 of the 241 double-blind patients entered the extension study and 207 received ≥1 open label injection into the gastrocnemius-soleus; 17-24% of patients also had injections into the hamstrings...
January 1, 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/28904682/severity-of-motor-dysfunction-in-children-with-cerebral-palsy-seen-in-enugu-nigeria
#3
Christian Chukwukere Ogoke, Sylvester Onabeke Iloeje
INTRODUCTION: Children with cerebral palsy (CP) have gross motor dysfunction (GMD) of varying degrees of severity. The Gross Motor Function Classification System (GMFCS) is widely used internationally to classify children with CP into functional severity levels. There are few reports on the use of GMFCS in Nigeria to determine the severity of motor dysfunction in children with CP. This study aims to classify children with CP in Enugu on the basis of severity of their GMD in order to ascertain their management needs...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28904628/tibial-derotational-osteotomies-in-two-neuromuscular-populations-comparing-cerebral-palsy-with-myelomeningocele
#4
R M Thompson, S Ihnow, L Dias, V Swaroop
PURPOSE: To review the outcomes of tibial derotational osteotomies (TDOs) as a function of complication and revision surgery rates comparing a cohort of children with myelodysplasia to a cohort with cerebral palsy (CP). METHODS: A chart review was completed on TDOs performed in a tertiary referral centre on patients with myelodysplasia or CP between 1985 and 2013 in patients aged > 5 years with > 2 years follow-up. Charts were reviewed for demographics, direction/degree of derotation, complications and need for re-derotation...
August 1, 2017: Journal of Children's Orthopaedics
https://www.readbyqxmd.com/read/28904579/dopa-responsive-dystonia-in-a-child-misdiagnosed-as-cerebral-palsy
#5
Dinkar Kulshreshtha, Pradeep K Maurya, Ajai K Singh, Anup K Thacker
Dopa-responsive dystonia also known as "Segawa's syndrome" was first described in 1976. The dystonia typically shows diurnal variations and is more marked toward the end of the day and improves in sleep. This entity is often misdiagnosed in the clinical setting, mostly due to the lack of awareness, and these patients are exposed to various treatment regimens and nonpharmacological measures. We present a boy being treated as dystonic cerebral palsy who showed significant improvement in dystonic symptoms with L-dopa therapy...
April 2017: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/28899888/protocol-for-a-systematic-review-of-instruments-for-the-assessment-of-quality-of-life-and-well-being-in-children-and-adolescents-with-cerebral-palsy
#6
Christine Mpundu-Kaambwa, Gang Chen, Elisabeth Huynh, Remo Russo, Julie Ratcliffe
INTRODUCTION: Cerebral palsy is the most common cause of physical disability in children and adolescents and is associated with impairments that may reduce the quality of life (QOL) of this population. Patient-reported outcome measures (PROMs) can facilitate the assessment of the effect of disease and treatment on QOL, from a patient viewpoint. The purpose of this systematic review is to identify PROMs that are used to measure QOL and subjective well-being (SWB) outcomes in young people with cerebral palsy and to evaluate the suitability of these PROMs for application in economic evaluations within this population...
September 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28892137/medical-treatment-of-dyskinetic-cerebral-palsy-translation-into-practice
#7
Pichet Termsarasab
No abstract text is available yet for this article.
September 11, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28886496/convulsive-status-epilepticus-in-a-quaternary-hospital-paediatric-intensive-care-unit-picu-in-south-africa-an-8-year-review
#8
Yavini Reddy, Yusentha Balakrishna, Lawrence Mubaiwa
PURPOSE: Convulsive status epilepticus (CSE) is associated with a high morbidity and mortality. This study aimed to describe the clinical profile, aetiology, neuroimaging and EEG findings as well as outcome of children with CSE in Sub-Saharan Africa. METHODS: This was a retrospective analysis of electronic records of children with CSE admitted to the Paediatric Intensive Care Unit (PICU) over an 8-year period from January 2007 to December 2014. RESULTS: Seventy six patients were admitted to the PICU with CSE and 55(72%) had refractory status epilepticus...
August 2, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/28884806/neurophysiological-mechanisms-and-functional-impact-of-mirror-movements-in-children-with-unilateral-spastic-cerebral-palsy-a-systematic-review
#9
REVIEW
Hsing-Ching Kuo, Kathleen M Friel, Andrew M Gordon
Children with unilateral spastic cerebral palsy (CP) often have mirror movements, i.e. involuntary imitations of unilateral voluntary movements of the contralateral upper extremity. The pathophysiology of mirror movements has been investigated in small and heterogeneous cohorts in the literature. Specific pathophysiology of mirror movements and their impact on upper extremity function require systematic investigation in larger and homogeneous cohorts of children with unilateral spastic CP. Here we review two possible neurophysiological mechanisms underlying mirror movements in children with CP and those with typical development: (1) an ipsilateral corticospinal tract projecting from the contralesional motor cortex (M1) to both upper extremities; (2) insufficient interhemispheric inhibition between the two M1s...
September 8, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28879344/prognosis-after-treatment-with-multiple-dental-implants-under-general-anesthesia-and-sedation-in-a-cerebral-palsy-patient-with-mental-retardation-a-case-report
#10
Young-Joon Hong, Jung-Bae Dan, Myung-Jin Kim, Hyun Jeong Kim, Kwang-Suk Seo
Cerebral palsy is a non-progressive disorder resulting from central nervous system damage caused by multiple factors. Almost all cerebral palsy patients have a movement disorder that makes dental treatment difficult. Oral hygiene management is difficult and the risks for periodontitis, dental caries and loss of multiple teeth are high. Placement of dental implants for multiple missing teeth in cerebral palsy patients needs multiple rounds of general anesthesia, and the prognosis is poor despite the expense...
June 2017: J Dent Anesth Pain Med
https://www.readbyqxmd.com/read/28878622/ganaxolone-a-new-treatment-for-neonatal-seizures
#11
REVIEW
Tamara Yawno, Suzie L Miller, Laura Bennet, Flora Wong, Jonathan J Hirst, Michael Fahey, David W Walker
Neonatal seizures are amongst the most common neurologic conditions managed by a neonatal care service. Seizures can exacerbate existing brain injury, induce "de novo" injury, and are associated with neurodevelopmental disabilities in post-neonatal life. In this mini-review, we present evidence in support of the use of ganaxolone, a GABA(A) agonist neurosteroid, as a novel neonatal therapy. We discuss evidence that ganaxolone can provide both seizure control and neuroprotection with a high safety profile when administered early following birth-related hypoxia, and show evidence that it is likely to prevent or reduce the incidence of the enduring disabilities associated with preterm birth, cerebral palsy, and epilepsy...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28872668/efficacy-of-oral-pharmacological-treatments-in-dyskinetic-cerebral-palsy-a-systematic-review
#12
REVIEW
Riccardo Masson, Emanuela Pagliano, Giovanni Baranello
AIM: To evaluate the actual evidence of efficacy of oral pharmacological treatments in the management of dyskinetic cerebral palsy (CP). METHOD: A systematic review was performed according to the American Academy for Cerebral Palsy and Developmental Medicine (AACPDM) and Preferred Reporting Items for Systematic Reviews and Meta-Analyses methodology. Articles were searched for in PubMed/MEDLINE, Scopus, Web of Science, Cochrane Library, Database of Reviews of Effectiveness, OTSeeker, Physiotherapy Evidence Database, REHABDATA, and ClinicalTrials...
September 5, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/28870053/-domestic-external-fixator-application-in-the-treatment-of-limb-deformities-7-289-cases-application-report
#13
S H Qin, B F Guo, X J Zheng, S F Jiao, H T Xia, A M Peng, Q Pan, J C Zang, Z J Wang
Objective: To discuss the clinical application and effects of domestic external fixator in the treatment of patients with malformations of limbs. Methods: A total of 7 289 patients with malformation of limbs who had been operated in Qin Sihe orthopedic surgery team from January 1989 to June 2016 were retrospective analyzed. The patients were treated with domestic external fixator, including 4 033 males and 3 256 females, aging from 2 to 82 years with a mean age of 23.4 years. There were 2 732 patients using Ilizarov external fixator, 4 713 patients using hybrid external fixator, 57 patients using monobrachial external fixator, 232 patients using Ilizarov external fixator and hybrid external fixator...
September 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28869434/effects-of-neuromuscular-electrical-stimulation-and-kinesio-taping-applications-in-children-with-cerebral-palsy-on-postural-control-and-sitting-balance
#14
Bülent Elbasan, Kamile Uzun Akkaya, Mufit Akyüz, Deran Oskay
BACKGROUND: Neurodevelopmental treatment (NDT), neuromuscular electrical stimulation (NMES), and Kinesio Taping (KT) applications are separately used to improve postural control and sitting balance in children with cerebral palsy (CP). OBJECTIVE: The aim of this study is to examine the combined effect of NDT, NMES and KT applications on postural control and sitting balance in children with CP. METHODS: Forty five children, in 3 groups, between the ages 5-12 years were included in the study...
August 21, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28854939/weight-supported-training-of-the-upper-extremity-in-children-with-cerebral-palsy-a-motor-learning-study
#15
Jeffrey W Keller, Hubertus J A van Hedel
BACKGROUND: Novel neurorehabilitation technologies build upon treatment principles derived from motor learning studies. However, few studies have investigated motor learning with assistive devices in children and adolescents with Cerebral Palsy (CP). The aim of this study was to investigate whether children with CP who trained with weight support in a playful, virtual environment would improve upper extremity task performance (i.e. skill acquisition), transfer, and retention, three aspects that indicate whether motor learning might have occurred or not...
August 30, 2017: Journal of Neuroengineering and Rehabilitation
https://www.readbyqxmd.com/read/28835518/a-lower-extremity-exoskeleton-improves-knee-extension-in-children-with-crouch-gait-from-cerebral-palsy
#16
Zachary F Lerner, Diane L Damiano, Thomas C Bulea
The ability to walk contributes considerably to physical health and overall well-being, particularly in children with motor disability, and is therefore prioritized as a rehabilitation goal. However, half of ambulatory children with cerebral palsy (CP), the most prevalent childhood movement disorder, cease to walk in adulthood. Robotic gait trainers have shown positive outcomes in initial studies, but these clinic-based systems are limited to short-term programs of insufficient length to maintain improved function in a lifelong disability such as CP...
August 23, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28834868/outcomes-of-intrathecal-baclofen-therapy-in-patients-with-cerebral-palsy-and-acquired-brain-injury
#17
Young Kwon Yoon, Kil Chan Lee, Han Eol Cho, Minji Chae, Jin Woo Chang, Won Seok Chang, Sung-Rae Cho
Intrathecal baclofen (ITB) has been known to reduce spasticity which did not respond to oral medications and botulinum toxin treatment. However, few results have been reported comparing the effects of ITB therapy in patients with cerebral palsy (CP) and acquired brain injury. This study aimed to investigate beneficial and adverse effects of ITB bolus injection and pump therapy in patients with CP and to compare outcomes to patients with acquired brain injury such as traumatic brain injury and hypoxic brain injury...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28832625/adjuvant-treatment-with-monosialoganglioside-may-improve-neurological-outcomes-in-neonatal-hypoxic-ischemic-encephalopathy-a-meta-analysis-of-randomized-controlled-trials
#18
Lei Sheng, Zhaohui Li
BACKGROUND: Ganglioside has a neuroprotective role in neonatal hypoxic-ischemic encephalopathy (HIE). This study aimed to evaluate the neurological outcomes of monosialoganglioside as adjuvant treatment for neonatal HIE by conducting a meta-analysis. METHODS: A comprehensive literature search was made in the Pubmed, EMBASE, Cochrane Library, Wanfang, CNKI, VIP databases through October 2016. Randomized controlled trials comparing monosialoganglioside with the usual treatment for newborns having HIE deemed eligible...
2017: PloS One
https://www.readbyqxmd.com/read/28829950/analysis-of-gait-patterns-pre-and-post-single-event-multilevel-surgery-in-children-with-cerebral-palsy-by-means-of-offset-wise-movement-analysis-profile-and-linear-fit-method
#19
Andrea Ancillao, Marjolein M van der Krogt, Annemieke I Buizer, Melinda M Witbreuk, Paolo Cappa, Jaap Harlaar
Gait analysis is used for the assessment of walking ability of children with cerebral palsy (CP), to inform clinical decision making and to quantify changes after treatment. To simplify gait analysis interpretation and to quantify deviations from normality, some quantitative synthetic descriptors were developed over the years, such as the Movement Analysis Profile (MAP) and the Linear Fit Method (LFM), but their interpretation is not always straightforward. The aims of this work were to: (i) study gait changes, by means of synthetic descriptors, in children with CP that underwent Single Event Multilevel Surgery; (ii) compare the MAP and the LFM on these patients; (iii) design a new index that may overcome the limitations of the previous methods, i...
August 19, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28826274/the-effect-of-a-running-intervention-on-running-ability-and-participation-in-children-with-cerebral-palsy-a-randomized-controlled-trial
#20
Noula Gibson, Annie Chappell, Amanda Marie Blackmore, Susan Morris, Gavin Williams, Natasha Bear, Garry Allison
PURPOSE: The purpose of this study is to evaluate effects of a running intervention on running ability and participation in children with cerebral palsy. MATERIALS AND METHOD: Children with cerebral palsy (9-18 years) with Gross Motor Function Classification System levels I-III were randomly assigned to a 12-week running intervention or usual care. Primary outcomes included improvement in running ability (assessed by Goal Attainment Scaling, high level mobility (assessed by the High-Level Mobility Assessment Tool) and participation (assessed by the Participation and Environment Measure for Children and Youth)...
August 21, 2017: Disability and Rehabilitation
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