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https://www.readbyqxmd.com/read/29138654/syphilis-and-hiv-infections-among-pregnant-women-attending-antenatal-clinics-in-republic-of-congo
#1
Roch Fabien Niama, Nadia Claricelle Loukabou Bongolo, Edith Sophie Bayonne Kombo, Ruth Yengo, Pembe Issamou Mayengue, Etoka-Beka Mandingha Kosso, Igor Louzolo, Lucette Macosso, Ghislain Dzeret, Angélie Serge Patrick Dzabatou Babeaux, Marie-Francke Puruehnce, Henri Joseph Parra
Introduction: HIV and syphilis during pregnancy remain a public health concern especially in developing countries. Pregnant women attending antenatal clinics sites for the first time between September and December 2011 and who accepted to participate in the study were enrolled. The objective was to estimate the syphilis and HIV infection rate in this population. Methods: A study was conducted in 44 selected ANCs from 12 departments (5 urban and 7 rural). Pregnant women who accepted to participate in the study, attending selected sentinel ANCs sites for the first time between September and December 2011 were enrolled...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29137847/comparison-between-radiological-semantic-features-and-lung-rads-in-predicting-malignancy-of-screen-detected-lung-nodules-in-the-national-lung-screening-trial
#2
Qian Li, Yoganand Balagurunathan, Ying Liu, Jin Qi, Matthew B Schabath, Zhaoxiang Ye, Robert J Gillies
RATIONALE: Lung computed tomography (CT) Screening Reporting and Data System (lung-RADS) has standardized follow-up and management decisions in lung cancer screening. To date, little is known how lung-RADS classification compares with radiological semantic features in risk prediction and diagnostic discrimination. OBJECTIVES: To compare the performance of radiological semantic features and lung-RADS in predicting nodule malignancy in lung cancer screening. METHODS: We used data and low-dose CT (LDCT) images from the National Lung Screening Trial (NLST)...
October 13, 2017: Clinical Lung Cancer
https://www.readbyqxmd.com/read/29137394/measuring-plasma-levels-of-three-micrornas-can-improve-the-accuracy-for-identification-of-malignant-breast-lesions-in-women-with-bi-rads-4-mammography
#3
Julia Alejandra Pezuk, Thiago Luiz Araujo Miller, José Luiz Barbosa Bevilacqua, Alfredo Carlos Simões Dornellas de Barros, Felipe Eduardo Martins de Andrade, Luiza Freire de Andrade E Macedo, Vera Aguilar, Amanda Natasha Menardo Claro, Anamaria Aranha Camargo, Pedro Alexandre Favoretto Galante, Luiz F L Reis
A BI-RADS category of 4 from a mammogram indicates suspicious breast lesions, which require core biopsies for diagnosis and have an approximately one third chance of being malignant. Human plasma contains many circulating microRNAs, and variations in their circulating levels have been associated with pathologies, including cancer. Here, we present a novel methodology to identify malignant breast lesions in women with BI-RADS 4 mammography. First, we used the miRNome array and qRT-PCR to define circulating microRNAs that were differentially represented in blood samples from women with breast tumor (BI-RADS 5 or 6) in comparison to controls (BI-RADS 1 or 2)...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29136831/rapid-method-for-determination-of-90-sr-in-seawater-by-liquid-scintillation-counting-with-an-extractive-scintillator
#4
Masaki Uesugi, Ryosuke Watanabe, Hiroaki Sakai, Akihiko Yokoyama
A rapid determination method of (90)Sr is developed for the monitoring of seawater around the Fukushima Daiichi Nuclear Power Plant (FDNPP). Three ideas of chemical separation and measurements to accelerate (90)Sr analysis are investigated. Strontium is co-precipitated in a two-step procedure with hydroxyapatite after the removal of magnesium phosphate in the presence of citric acid. The purification process of strontium is in combination with solid phase extraction disks. One or two sheets of Sr Rad disk and cyclic operations are examined to eliminate interfering substances and secure the exchange capacity...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136178/identification-of-genomic-regions-associated-with-sex-in-pacific-halibut
#5
Daniel P Drinan, Timothy Loher, Lorenz Hauser
Understanding and identifying the genetic mechanisms responsible for sex-determination are important for species management, particularly in exploited fishes where sex biased harvest could have implications on population dynamics and long-term persistence. The Pacific halibut (Hippoglossus stenolepis) supports important fisheries in the North Pacific Ocean. The proportion of each sex in the annual harvest is currently estimated using growth curves, but genetic techniques may provide a more accurate method. We used restriction-site associated DNA (RAD) sequencing to identify RAD-tags that were linked to genetic sex, based on differentiation (FST) between the sexes...
November 9, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29136139/rad-seq-reveals-patterns-of-additive-polygenic-variation-caused-by-spatially-varying-selection-in-the-american-eel-anguilla-rostrata
#6
Charles Babin, Pierre-Alexandre Gagnaire, Scott A Pavey, Louis Bernatchez
The American Eel (Anguilla rostrata) has an exceptional life cycle characterised by panmictic reproduction at the species scale, random dispersal and selection in a highly heterogeneous habitat extending from subtropical to subarctic latitudes. The genetic consequences of spatially-varying selection in this species have been investigated for decades, revealing subtle clines in allele frequency at a few loci that contrast with complete panmixia on the vast majority of the genome. Because reproduction homogenizes allele frequencies every generation, sampling size and genomic coverage are critical to reach sufficient power to detect selected loci in this context...
November 10, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29135083/comparison-of-the-anticancer-properties-of-a-novel-valproic-acid-prodrug-to-leading-histone-deacetylase-inhibitors
#7
Nataly Tarasenko, Hanna Chekroun-Setti, Abraham Nudelman, Ada Rephaeli
The HDAC inhibitory activity of valproic acid (VPA) has led to on-going evaluation of it as an anticancer agent. The histone deacetylase (HDAC) inhibitor AN446, a prodrug of VPA, releases the acid upon metabolic degradation. AN446 is >60 fold more potent than VPA in killing cancer cells in vitro. Herein, we compare the activities of AN446, as an anticancer agent, to those of representative types from each of the four major classes of HDAC inhibitors (HDACIs): vorinostat, romidepsin, entinostat and VPA. AN446 exhibited the greatest selectivity and HDAC inhibitory activity against cancer cells...
November 14, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29135073/prostate-cancer-detection-using-quantitative-t2-and-t2-weighted-imaging-the-effects-of-5-alpha-reductase-inhibitors-in-men-on-active-surveillance
#8
Francesco Giganti, Giulio Gambarota, Caroline M Moore, Nicola L Robertson, Neil McCartan, Charles Jameson, Simon R J Bott, Mathias Winkler, Brandon Whitcher, Ramiro Castro-Santamaria, Mark Emberton, Clare Allen, Alex Kirkham
BACKGROUND: T2 -weighted imaging (T2 -WI) information has been used in a qualitative manner in the assessment of prostate cancer. Quantitative derivatives (T2 relaxation time) can be generated from T2 -WI. These outputs may be useful in helping to discriminate clinically significant prostate cancer from background signal. PURPOSE/HYPOTHESIS: To investigate changes in quantitative T2 parameters in lesions and noncancerous tissue of men on active surveillance for prostate cancer taking dutasteride 0...
November 14, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/29134729/maintaining-their-genetic-distance-little-evidence-for-introgression-between-widely-hybridising-species-of-geum-with-contrasting-mating-systems
#9
Crispin Y Jordan, Konrad Lohse, Frances Turner, Marian Thomson, Karim Gharbi, Richard A Ennos
Within the plant kingdom many genera contain sister lineages with contrasting outcrossing and inbreeding mating systems that are known to hybridise. The evolutionary fate of these sister lineages is likely to be influenced by the extent to which they exchange genes. We measured gene flow between outcrossing Geum rivale and selfing G. urbanum, sister species that hybridise in contemporary populations. We generated and used a draft genome of G. urbanum to develop dd-RAD data scorable in both species. Coalescent analysis of RAD data from allopatric populations indicated that the species diverged 2-3 Mya, and that historical gene flow between them was extremely low (1 migrant every 25 generations)...
November 13, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/29134355/extracellular-contrast-agent-enhanced-mri-15-min-delayed-phase-may-improve-the-diagnostic-performance-for-hepatocellular-carcinoma-in-patients-with-chronic-liver-disease
#10
Si Eun Lee, Chansik An, Shin Hye Hwang, Jin-Young Choi, Kyunghwa Han, Myeong-Jin Kim
OBJECTIVES: To determine the value of a 15-min delayed phase in extracellular contrast agent (ECA)-enhanced magnetic resonance imaging (MRI) for evaluation of hepatocellular carcinoma (HCC) in patients with chronic liver disease. METHODS: Between 2014 and 2015, 103 patients with chronic liver disease underwent ECA-enhanced MRI; 133 lesions consisting of 107 HCCs, 23 benign lesions and three non-HCC malignancies were identified with pathological or clinical diagnosis...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29134351/3d-t2-weighted-imaging-to-shorten-multiparametric-prostate-mri-protocols
#11
Stephan H Polanec, Mathias Lazar, Georg J Wengert, Hubert Bickel, Claudio Spick, Martin Susani, Shahrokh Shariat, Paola Clauser, Pascal A T Baltzer
OBJECTIVES: To determine whether 3D acquisitions provide equivalent image quality, lesion delineation quality and PI-RADS v2 performance compared to 2D acquisitions in T2-weighted imaging of the prostate at 3 T. METHODS: This IRB-approved, prospective study included 150 consecutive patients (mean age 63.7 years, 35-84 years; mean PSA 7.2 ng/ml, 0.4-31.1 ng/ml). Two uroradiologists (R1, R2) independently rated image quality and lesion delineation quality using a five-point ordinal scale and assigned a PI-RADS score for 2D and 3D T2-weighted image data sets...
November 13, 2017: European Radiology
https://www.readbyqxmd.com/read/29133247/contrast-enhanced-ultrasound-identifies-hepatocellular-carcinoma-in-cirrhosis-a-large-multicenter-retrospective-study
#12
Eleonora Terzi, Massimo Iavarone, Maurizio Pompili, Letizia Veronese, Giuseppe Cabibbo, Mirella Fraquelli, Laura Riccardi, Ludovico De Bonis, Angelo Sangiovanni, Simona Leoni, Maria Assunta Zocco, Sandro Rossi, Nicola Alessi, Stephanie R Wilson, Fabio Piscaglia, Alessandro Granito, Veronica Salvatore, Francesco Tovoli, Matteo Angelo Manini, Gian Lodovico Rapaccini, Maria Elena Ainora, Valentina Ravetta, Giorgia Ghittoni, Agostino Ventra, Giuseppe Mogavero
BACKGROUND & AIMS: The use of contrast enhanced ultrasound (CEUS) for the diagnosis of hepatocellular carcinoma (HCC) in cirrhosis was questioned for the risk of false positive diagnosis in case of cholangiocarcinoma. The American College of Radiology has recently released a scheme (CEUS LI-RADS) classifying lesions at risk for HCC investigated by CEUS. Aim of the present study was to validate this LI-RADS scheme for the diagnosis of HCC. METHODS: A total of 1006 nodules in 848 patients with chronic liver disease at risk for HCC collected in 5 Italian centers were retrospectively analyzed...
November 10, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29132714/psma-rads-version-1-0-a-step-towards-standardizing-the-interpretation-and-reporting-of-psma-targeted-pet-imaging-studies
#13
EDITORIAL
Steven P Rowe, Kenneth J Pienta, Martin G Pomper, Michael A Gorin
The use of [(18)F]- and [(68)Ga]-labeled inhibitors of prostate-specific membrane antigen (PSMA) for positron emission tomography (PET) imaging of prostate cancer is now widespread. We have proposed a reporting and data system called PSMA-RADS version 1.0, which is a framework for classifying PSMA-targeted PET scans and individual findings into categories that reflect the likelihood of the presence of prostate cancer.
November 10, 2017: European Urology
https://www.readbyqxmd.com/read/29131761/2017-version-of-li-rads-for-ct-and-mr-imaging-an-update
#14
Khaled M Elsayes, Jonathan C Hooker, Michelle M Agrons, Ania Z Kielar, An Tang, Kathryn J Fowler, Victoria Chernyak, Mustafa R Bashir, Yuko Kono, Richard K Do, Donald G Mitchell, Aya Kamaya, Elizabeth M Hecht, Claude B Sirlin
The Liver Imaging Reporting and Data System (LI-RADS) is a reporting system created for the standardized interpretation of liver imaging findings in patients who are at risk for hepatocellular carcinoma (HCC). This system was developed with the cooperative and ongoing efforts of an American College of Radiology-supported committee of diagnostic radiologists with expertise in liver imaging and valuable input from hepatobiliary surgeons, hepatologists, hepatopathologists, and interventional radiologists. In this article, the 2017 version of LI-RADS for computed tomography and magnetic resonance imaging is reviewed...
November 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29128994/radiologists-preferences-regarding-content-of-prostate-mri-reports-a-survey-of-the-society-of-abdominal-radiology
#15
Benjamin Spilseth, Daniel J Margolis, Sangeet Ghai, Nayana U Patel, Andrew B Rosenkrantz
PURPOSE: To evaluate radiologist preferences regarding specific content that warrants inclusion in prostate MRI reports. METHODS: Sixty-one members of the Society of Abdominal Radiology responded to a 74-item survey regarding specific content warranted in prostate MRI reports, conducted in August 2016. RESULTS: General items deemed essential report content by ≥ 50% of respondents were prostate volume (80%), extent of prostate hemorrhage (74%), TURP defects (69%), coil type (64%), BPH (61%), contrast dose (61%), contrast agent (59%), medications administered (59%), and magnet strength (54%)...
November 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29128006/neck-imaging-reporting-and-data-system
#16
REVIEW
Ashley H Aiken, Patricia A Hudgins
The Neck Imaging Reporting and Data System (NI-RADS) is a practical and clinically useful imaging surveillance template designed to guide appropriate imaging follow-up and next-management steps. This article is a practical guide for using NI-RADS to reduce report-generation time for radiologists and create useful reports for referring clinicians and patients. A review of the report template and legend is followed by a case-based and pictorial review of the proper assignment of NI-RADS categories.
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29127877/breast-arterial-calcification-on-screening-mammography-can-predict-significant-coronary-artery-disease-in-women
#17
Brendan S Kelly, Emer ScanlON, Helen Heneghan, Ciaran E Redmond, Gerard M Healy, Enda Mc Dermott, Eric J Heffernan, Ruth Prichard, Sorcha Mc Nally
INTRODUCTION: Breast Arterial Calcification (BAC) on digital mammography has been associated with an increased risk of Coronary Artery Disease (CAD). We aimed to investigate the association of BAC with findings on Coronary Computed Tomography Angiography (CCTA) within a cohort of women from the national breast screening program. METHODS: Symptomatic women (chest pain) aged between 50 and 65 who underwent a CCTA and who also had a screening mammography between 2014 and 2015 were recorded...
November 3, 2017: Clinical Imaging
https://www.readbyqxmd.com/read/29122667/is-breast-mri-a-helpful-additional-diagnostic-test-in-suspicious-mammographic-microcalcifications
#18
Pascal A T Baltzer, Barbara Bennani-Baiti, Alexander Stöttinger, Alexander Bumberger, Panagiotis Kapetas, Paola Clauser
PURPOSE: Microcalcifications are a common finding in mammography and usually require invasive procedures to diagnose or exclude malignancy. As many microcalcifications are due to benign lesions, we wanted to assess whether breast MRI as an additional diagnostic tool may be used to distinguish benign from malignant in this setting. MATERIALS AND METHODS: Eligible for this retrospective, IRB-approved observational study were 858 consecutive patients (mean age 54±11years) undergoing stereotactically-guided biopsies of suspicious mammographic microcalcifications during three year at our institution...
November 6, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29122647/an-automatic-system-for-the-comprehensive-retrospective-analysis-of-cardiac-rhythms-in-resuscitation-episodes
#19
Ali Bahrami Rad, Trygve Eftestøl, Unai Irusta, Jan Terje Kvaløy, Lars Wik, Jo Kramer-Johansen, Aggelos K Katsaggelos, Kjersti Engan
AIM: An automatic resuscitation rhythm annotator (ARA) would facilitate and enhance retrospective analysis of resuscitation data, contributing to a better understanding of the interplay between therapy and patient response. The objective of this study was to define, implement, and demonstrate an ARA architecture for complete resuscitation episodes, including chest compression pauses (CC-pauses) and chest compression intervals (CC-intervals). METHODS: We analyzed 126...
November 6, 2017: Resuscitation
https://www.readbyqxmd.com/read/29120082/substantial-differences-in-bias-between-single-digest-and-double-digest-rad-seq-libraries-a-case-study
#20
Sarah P Flanagan, Adam G Jones
The tradeoffs of using single-digest versus double-digest restriction site associated DNA sequencing (RAD-seq) protocols have been widely discussed. However, no direct empirical comparisons of the two methods have been conducted. Here, we sampled a single population of Gulf pipefish (Syngnathus scovelli) and genotyped 444 individuals using RAD-seq. Sixty individuals were subjected to single-digest RAD-seq (sdRAD-seq), and the remaining 384 individuals were genotyped using a double-digest RAD-seq (ddRAD-seq) protocol...
November 9, 2017: Molecular Ecology Resources
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