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https://www.readbyqxmd.com/read/29774594/in-vivo-characterization-of-3d-skull-and-brain-motion-during-dynamic-head-vibration-using-magnetic-resonance-elastography
#1
Ziying Yin, Yi Sui, Joshua D Trzasko, Phillip J Rossman, Armando Manduca, Richard L Ehman, John Huston
PURPOSE: To introduce newly developed MR elastography (MRE)-based dual-saturation imaging and dual-sensitivity motion encoding schemes to directly measure in vivo skull-brain motion, and to study the skull-brain coupling in volunteers with these approaches. METHODS: Six volunteers were scanned with a high-performance compact 3T-MRI scanner. The skull-brain MRE images were obtained with a dual-saturation imaging where the skull and brain motion were acquired with fat- and water-suppression scans, respectively...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29770735/the-diagnostic-value-of-using-combined-mr-diffusion-parameters-to-differentiate-between-low-and-high-grade-meningioma
#2
Kerim Aslan, Hediye Pinar Gunbey, Leman Tomak, Lutfi Incesu
OBJECTIVE: The purpose of this study was to examine whether the combined use of MR diffusion parameters [Diffusion tensor imaging (DTI)-apparent diffusion coefficient (ADC), fractional anisotropy (FA), axial diffusivity (AD), and radial diffusivity (RD)] could provide a more accurate diagnosis in differentiating between low-grade and atypical/anaplastic (high-grade) meningioma. METHODS: Pathologically proven 45 meningioma patients [32 low-grade, 13 high-grade (11 atypical and 2 anaplastic)] who had received DTI before surgery were assessed retrospectively by 2 independent observers...
May 17, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29768967/interleukin-1-receptor-1-deletion-in-focal-and-diffuse-experimental-traumatic-brain-injury-in-mice
#3
Joon Yong Chung, Nicolas Krapp, Limin Wu, Sevda Lule, Lauren McAllister, William Edmiston Iii, Samantha Martin, Emily Levy, Tanya Songtachalert, John Sherwood, Erin Buckley, Bharat Sanders, Saef Izzy, Suzanne Hickman, Shuzhen Guo, Josephine Lok, Joseph El Khoury, Eng Lo, David Kaplan, Michael Whalen
Important differences in the biology of focal and diffuse traumatic brain injury (TBI) subtypes may result in unique pathophysiological responses to shared molecular mechanisms. Interleukin-1 (IL-1) signaling has been tested as a potential therapeutic target in preclinical models of cerebral contusion and diffuse TBI, and in a phase II clinical trial, but no published studies have examined IL-1 signaling in an impact/acceleration closed head injury (CHI) model. We hypothesized that genetic deletion of IL-1 receptor-1 (IL-1R1 KO) would be beneficial in focal (contusion) and CHI in mice...
May 17, 2018: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29764461/characterization-of-a-new-apple-luteovirus-identified-by-high-throughput-sequencing
#4
Huawei Liu, Liping Wu, Ekaterina Nikolaeva, Kari Peter, Zongrang Liu, Dimitre Mollov, Mengji Cao, Ruhui Li
BACKGROUND: 'Rapid Apple Decline' (RAD) is a newly emerging problem of young, dwarf apple trees in the Northeastern USA. The affected trees show trunk necrosis, cracking and canker before collapse in summer. In this study, we discovered and characterized a new luteovirus from apple trees in RAD-affected orchards using high-throughput sequencing (HTS) technology and subsequent Sanger sequencing. METHODS: Illumina NextSeq sequencing was applied to total RNAs prepared from three diseased apple trees...
May 15, 2018: Virology Journal
https://www.readbyqxmd.com/read/29762606/intensity-modulated-directional-torsion-sensor-based-on-in-line-optical-fiber-mach-zehnder-interferometer
#5
Qinjiang Fu, Jingdong Zhang, Chuancan Liang, Iroegbu Paul Ikechukwu, Guolu Yin, Lei Lu, Yifan Shao, Liu Liu, Dongxiao Liu, Tao Zhu
In this Letter, we demonstrated an intensity-modulated directional torsion sensor based on an in-line Mach-Zehnder interferometer in single-mode fiber. A non-circular symmetric perturbation is created to excite non-circular symmetric cladding mode and then interference with the core mode at the second perturbation. An initial rotation angle is designed between two perturbations for the purpose of discriminating the torsion direction. Both experimental and theoretical results enforce that the spectral peak/dip turns to be the dip/peak when the fiber is twisted from the counter-clockwise to the clockwise direction...
May 15, 2018: Optics Letters
https://www.readbyqxmd.com/read/29760917/factors-associated-with-glycemic-status-and-ability-to-adapt-to-changing-demands-in-people-with-and-without-type-2-diabetes-mellitus-a-cross-sectional-study
#6
Bertha Cecilia Salazar-González, Esther C Gallegos-Cabriales, Alicia Rivera-Castillo, Arnulfo González-Cantú, Marco Vinicio Gómez-Meza, Jesús Zacarías Villarreal-Pérez
Objectives: Type 2 diabetes mellitus studies focus on metabolic indicators and different self-reported lifestyle or care behaviors. Self-reported instruments involve conscious process therefore responses might not reflect reality. Meanwhile implicit responses involve automatic, unconscious processes underlying social judgments and behavior. No studies have explored the combined influence of both metabolic indicators and implicit responses on lifestyle practices in type 2 diabetes mellitus patients...
2018: SAGE Open Medicine
https://www.readbyqxmd.com/read/29760203/a-dense-linkage-map-of-lake-victoria-cichlids-improved-the-pundamilia-genome-assembly-and-revealed-a-major-qtl-for-sex-determination
#7
Philine G D Feulner, Julia Schwarzer, Marcel P Haesler, Joana I Meier, Ole Seehausen
Genetic linkage maps are essential for comparative genomics, high quality genome sequence assembly and fine scale quantitative trait locus (QTL) mapping. In the present study we identified and genotyped markers via restriction-site associated DNA (RAD) sequencing and constructed a genetic linkage map based on 1,597 SNP markers of an interspecific F2 cross of two closely related Lake Victoria cichlids ( Pundamilia pundamilia and P. sp. 'red head'). The SNP markers were distributed on 22 linkage groups and the total map size was 1,594 cM with an average marker distance of 1...
May 14, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29760063/elastic-coupling-power-stroke-mechanism-of-the-f-1-atpase-molecular-motor
#8
James L Martin, Robert Ishmukhametov, David Spetzler, Tassilo Hornung, Wayne D Frasch
The angular velocity profile of the 120° F1 -ATPase power stroke was resolved as a function of temperature from 16.3 to 44.6 °C using a ΔμATP = -31.25 k B T at a time resolution of 10 μs. Angular velocities during the first 60° of the power stroke (phase 1) varied inversely with temperature, resulting in negative activation energies with a parabolic dependence. This is direct evidence that phase 1 rotation derives from elastic energy (spring constant, κ = 50 k B T ·rad-2 ). Phase 2 of the power stroke had an enthalpic component indicating that additional energy input occurred to enable the γ-subunit to overcome energy stored by the spring after rotating beyond its 34° equilibrium position...
May 14, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29759782/regional-left-ventricular-electrical-activation-and-peak-contraction-are-closely-related-in-candidates-for-cardiac-resynchronization-therapy
#9
Masih Mafi-Rad, Jetske Van't Sant, Yuri Blaauw, Pieter A Doevendans, Maarten J Cramer, Harry J Crijns, Frits W Prinzen, Mathias Meine, Kevin Vernooy
OBJECTIVES: This study determined the relationship between the timing of left ventricular (LV) electrical activation and peak contraction at potential LV pacing locations in candidates for cardiac resynchronization therapy (CRT). BACKGROUND: Targeting the LV lead to the region of latest electrical activation or the segment of latest peak contraction has both been shown to improve CRT response. Whether these regions correspond within CRT patients is uncertain. METHODS: Twenty-eight consecutive CRT candidates underwent intraprocedural coronary venous electroanatomic mapping using EnSite NavX...
August 2017: JACC. Clinical Electrophysiology
https://www.readbyqxmd.com/read/29758996/patterns-of-malignant-non-mass-enhancement-on-3-t-breast-mri-help-predict-invasiveness-using-the-bi-rads-lexicon-fifth-edition
#10
Seung Min Lee, Kyung Jin Nam, Ki Seok Choo, Jin You Kim, Dong Wook Jeong, Hyun Yul Kim, Jee Yeon Kim
Background Non-mass enhancements (NME) with invasive components account for 10-42% of total malignant NMEs. The factors associated with invasiveness on magnetic resonance imaging (MRI) could be useful for clinical assessment and treatment. Purpose To evaluate the clinical significances of the distributions and internal enhancement patterns (IEP) of malignant NMEs on 3-T breast MRI. Material and Methods A total of 448 consecutive women with newly diagnosed breast cancer that had undergone preoperative MRI and surgery between February 2013 and March 2016 were identified...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29757986/medicinal-plants-used-in-the-treatment-of-human-immunodeficiency-virus
#11
REVIEW
Bahare Salehi, Nanjangud V Anil Kumar, Bilge Şener, Mehdi Sharifi-Rad, Mehtap Kılıç, Gail B Mahady, Sanja Vlaisavljevic, Marcello Iriti, Farzad Kobarfard, William N Setzer, Seyed Abdulmajid Ayatollahi, Athar Ata, Javad Sharifi-Rad
Since the beginning of the epidemic, human immunodeficiency virus (HIV) has infected around 70 million people worldwide, most of whom reside is sub-Saharan Africa. There have been very promising developments in the treatment of HIV with anti-retroviral drug cocktails. However, drug resistance to anti-HIV drugs is emerging, and many people infected with HIV have adverse reactions or do not have ready access to currently available HIV chemotherapies. Thus, there is a need to discover new anti-HIV agents to supplement our current arsenal of anti-HIV drugs and to provide therapeutic options for populations with limited resources or access to currently efficacious chemotherapies...
May 14, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29757090/use-of-spectroscopic-and-zeta-potential-techniques-to-study-the-interaction-between-lysozyme-and-curcumin-in-the-presence-of-silver-nanoparticles-at-different-sizes
#12
Maryam Kamshad, MahtabJahan Shah Talab, Sima Beigoli, Atena Sharifi Rad, Jamshidkhan Chamani
This article describes, for the first time, the effect of three different sizes of silver nanoparticles on the binding of curcumin to lysozyme as examined by spectroscopic and zeta potential techniques at physiological conditions. The binding constants of curcumin to lysozyme in the presence of silver nanoparticles were measured. Based on the results of synchronous fluorescence and three-dimensional fluorescence spectroscopy, the presence of the different sizes of silver nanoparticles caused conformational changes in lysozyme during the binding of curcumin...
May 14, 2018: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29756456/no-time-to-delay-fiebig-stages-and-referral-in-acute-hiv-infection-seattle-primary-infection-program-experience
#13
Joanne Stekler, Kenneth Tapia, Janine Maenza, Claire E Stevens, George Ure, Joshua O'Neal, Aric Lane, James I Mullins, Robert Coombs, Sarah E Holte, Ann Cornwall Collier
INTRODUCTION: There has been increasing recognition of the importance of diagnosing individuals during the earliest stages of HIV infection. MATERIALS AND METHODS: Sera from individuals referred to a primary HIV infection research program were screened using the IgG-sensitive Vironostika HIV-1 Microelisa System, IgG/IgM-sensitive GS HIV-1/HIV-2 Plus O antibody EIA, or Abbott ARCHITECT HIV Ag/Ab Combo assay and confirmed by the Bio-Rad Multispot and Western Blot...
May 14, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29755360/healthy-lung-vessel-morphology-derived-from-thoracic-computed-tomography
#14
Michael Pienn, Caroline Burgard, Christian Payer, Alexander Avian, Martin Urschler, Rudolf Stollberger, Andrea Olschewski, Horst Olschewski, Thorsten Johnson, Felix G Meinel, Zoltán Bálint
Knowledge of the lung vessel morphology in healthy subjects is necessary to improve our understanding about the functional network of the lung and to recognize pathologic deviations beyond the normal inter-subject variation. Established values of normal lung morphology have been derived from necropsy material of only very few subjects. In order to determine morphologic readouts from a large number of healthy subjects, computed tomography pulmonary angiography (CTPA) datasets, negative for pulmonary embolism, and other thoracic pathologies, were analyzed using a fully-automatic, in-house developed artery/vein separation algorithm...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29755006/multiparametric-magnetic-resonance-imaging-for-bladder-cancer-development-of-vi-rads-vesical-imaging-reporting-and-data-system
#15
REVIEW
Valeria Panebianco, Yoshifumi Narumi, Ersan Altun, Bernard H Bochner, Jason A Efstathiou, Shaista Hafeez, Robert Huddart, Steve Kennish, Seth Lerner, Rodolfo Montironi, Valdair F Muglia, Georg Salomon, Stephen Thomas, Hebert Alberto Vargas, J Alfred Witjes, Mitsuru Takeuchi, Jelle Barentsz, James W F Catto
CONTEXT: Management of bladder cancer (BC) is primarily driven by stage, grade, and biological potential. Knowledge of each is derived using clinical, histopathological, and radiological investigations. This multimodal approach reduces the risk of error from one particular test, but may present a staging dilemma when results conflict. Multiparametric magnetic resonance imaging (mpMRI) may improve patient care through imaging of the bladder with better resolution of the tissue planes than computed tomography and without radiation exposure...
May 10, 2018: European Urology
https://www.readbyqxmd.com/read/29753588/effects-of-alpha-lipoic-acid-supplementation-on-c-reactive-protein-level-a-systematic-review-and-meta-analysis-of-randomized-controlled-clinical-trials
#16
S Saboori, E Falahi, E Eslampour, M Zeinali Khosroshahi, E Yousefi Rad
BACKGROUND AND AIM: The aim of this meta-analysis was to assess effects of alpha-lipoic acid supplementation on C-reactive protein (CRP) levels in clinical trial studies. METHODS AND RESULTS: A systematic search was carried out on clinical trial studies published in PubMed, ISI Web of Science, Cochrane Library and Scopus databases completed by manual search on reference list of eligible studies accomplished by November 4, 2017. Of a total number of 508 studies found in the first step of literature search, only 11 were included with 264 participants in supplementation groups and 287 in control groups...
April 17, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29753186/combination-of-pi3k-akt-pathway-inhibition-and-plk1-depletion-can-enhance-chemosensitivity-to-gemcitabine-in-pancreatic-carcinoma
#17
Yonghuan Mao, Ling Xi, Quan Li, Sheng Wang, Zeling Cai, Xinhua Zhang, Chunzhao Yu
The prognosis of pancreatic cancer (PC) remains pessimistic because of the difficulty in early diagnosis as well as the little advance in chemotherapy. Although being the first-line chemotherapy drug for PC at present, gemcitabine still has some disadvantages, such as low drug sensitivity and significant side effects. Thus, how to further improve the sensitivity of PC cells to gemcitabine is still a difficult subject in the field of pancreatic cancer-treatment. Polo-like kinase 1 (Plk1) is closely related to poor outcome in many malignant tumors and its high expression is linked to chemoresistance in PC...
May 9, 2018: Translational Oncology
https://www.readbyqxmd.com/read/29753168/serum-timp1-and-timp2-concentration-in-patients-with-different-grades-of-meningioma
#18
Farhad Mashayekhi, Alia Saberi, Sohail Mashayekhi
OBJECTIVE: Meningiomas are common primary brain tumors that constitute about 13% of all intracranial tumors. Matrix metalloproteinase-9 (MMP-9) is able to degrade the extracellular matrix and basement membrane leading to cancer cell invasion and metastasis. MMPs are specifically inhibited by a family of small extracellular proteins known as the tissue inhibitors of metalloproteinases (TIMPs). The objective of this project was to evaluate serum concentration of TIMP-1 and TIMP-2 in patients with different grades of meningioma...
May 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29752991/cerebrolysin-attenuates-hyperalgesia-photophobia-and-neuroinflammation-in-a-nitroglycerin-induced-migraine-model-in-rats
#19
Javad Mahmoudi, Gisou Mohaddes, Marjan Erfani, Saeed Sadigh-Eteghad, Pouran Karimi, Mojgan Rajabi, Siamak Reyhani-Rad, Fereshteh Farajdokht
Chronic migraine dramatically affects the quality of life in the migraineurs. This study examined the effect of chronic cerebrolysin (CBL) treatment on the migraine-associated symptoms in a rat model of migraine. Experiments were carried out on 8 weeks, male Wistar rats. Chronic migraine was modeled by injection (10 mg/kg, i.p) of nitroglycerin (NTG) on days 3, 5, 7, and 9. CBL (2.5 and 5 ml/kg, i.p.) was injected every day for 10 days. Mechanical and thermal withdrawal thresholds of the hind paw were examined by von Frey hairs and hot plate, respectively...
May 9, 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29752491/evaluating-the-size-criterion-for-pi-radsv2-category-5-upgrade-is-15-mm-the-best-threshold
#20
Julie Y An, Stephanie A Harmon, Sherif Mehralivand, Marcin Czarniecki, Clayton P Smith, Julie A Peretti, Bradford J Wood, Peter A Pinto, Peter L Choyke, Joanna H Shih, Baris Turkbey
PURPOSE: The purpose of the study was to determine if the ≥ 15 mm threshold currently used to define PIRADS 5 lesions is the optimal size threshold for predicting high likelihood of clinically significant (CS) cancers. MATERIALS: Three hundred and fifty-eight lesions that may be changed from category 4 to 5 or vice versa on the basis of the size criterion (category 4: n = 288, category 5: n = 70) from 255 patients were evaluated. Kendall's tau-b statistic accounting for inter-lesion correlation, generalized estimation equation logistic regression, and receiver operating curve analysis evaluated two lesion size-metrics (lesion diameter and relative lesion diameter-defined as lesion diameter/prostate volume) for ability to identify CS (Gleason grade ≥ 3 + 4) cancer at targeted biopsy...
May 11, 2018: Abdominal Radiology
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