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Non-tuberculous mycobacteria

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https://www.readbyqxmd.com/read/28931915/non-tuberculous-mycobacteria-isolated-from-pulmonary-samples-in-sub-saharan-africa-a-systematic-review-and-meta-analyses
#1
Catherine Okoi, Suzanne T B Anderson, Martin Antonio, Sarah N Mulwa, Florian Gehre, Ifedayo M O Adetifa
Pulmonary non-tuberculous mycobacterial (NTM) disease epidemiology in sub-Saharan Africa is not as well described as for pulmonary tuberculosis. Earlier reviews of global NTM epidemiology only included subject-level data from one sub-Saharan Africa country. We systematically reviewed the literature and searched PubMed, Embase, Popline, OVID and Africa Wide Information for articles on prevalence and clinical relevance of NTM detection in pulmonary samples in sub-Saharan Africa. We applied the American Thoracic Society/Infectious Disease Society of America criteria to differentiate between colonisation and disease...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28924121/pleuritis-caused-by-mycobacterium-kyorinense-without-pulmonary-involvement
#2
Tatsuyoshi Ikeue, Hiroshi Yoshida, Eiichiro Tanaka, Issei Ohi, Susumu Noguchi, Akari Fukao, Satoshi Terashita, Sadao Horikawa, Takakazu Sugita
We herein describe the first known case of pleuritis caused by Mycobacterium kyorinense without pulmonary involvement. A 48-year-old man undergoing immunosuppressant therapy presented with cough and dyspnea. An accumulation of pleural fluid was noted; however, computed tomography revealed no pulmonary lesions. Cultures of the fluid yielded non-tuberculous mycobacteria, which was identified as Mycobacterium kyorinense. The patient recovered after 6 months of therapy with clarithromycin and moxifloxacin. Clinicians should be aware that Mycobacterium kyorinense can cause pleuritis without pulmonary involvement...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28919618/molecular-detection-and-differentiation-of-mycobacterium-tuberculosis-complex-and-non-tuberculous-mycobacterium-in-the-clinical-specimens-by-real-time-pcr
#3
M M Rahman, M R Rahim, A Khaled, T A Nasir, F Nasrin, M A Hasan
Mycobacteria are subdivided into three groups: the Mycobacterium tuberculosis complex, the non-tuberculous mycobacteria called NTM or MOTT (Mycobacteria Other Than Tuberculosis) and Mycobacterium leprae. Over the past few decades, the incidence of infections caused by NTM has increased world wide. The differentiation of Mycobacterium tuberculosis complex from NTM is of primary importance for infection control and choice of antimicrobial therapy. However, there is so far no report in Bangladesh about the detection of NTM and hence differentiation of MTB and NTM...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28911363/bronchial-angles-are-associated-with-nodular-bronchiectatic-non-tuberculous-mycobacteria-lung-disease
#4
T Lee, J Y Park, H Y Lee, H-J Lim, J S Park, Y-J Cho, T J Kim, K W Lee, J H Lee, C-T Lee, H I Yoon
BACKGROUND: The nodular bronchiectatic (NB) form of non-tuberculous mycobacteria (NTM) lung disease usually involves the right middle lobe (RML) and the left upper lobe lingular segment. However, the reason underlying this preference is not known. METHODS: Fifty patients with NB NTM lung disease who had both positive NTM culture(s) and NB lesions in the RML or lingular segment on computed tomography (CT) of the chest, and 100 healthy subjects matched for sex, age, height and body weight with normal chest CT, were randomly selected...
October 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/28886145/application-of-a-whole-blood-mycobacterial-growth-inhibition-assay-to-study-immunity-against-mycobacterium-tuberculosis-in-a-high-tuberculosis-burden-population
#5
Richard Baguma, Adam Penn-Nicholson, Erica Smit, Mzwandile Erasmus, Jonathan Day, Lebohang Makhethe, Marwou de Kock, E Jane Hughes, Michele van Rooyen, Bernadette Pienaar, Lynnett Stone, Willem Hanekom, Michael J Brennan, Robert S Wallis, Mark Hatherill, Thomas J Scriba
The determinants of immunological protection against Mycobacterium tuberculosis (M.tb) infection in humans are not known. Mycobacterial growth inhibition assays have potential utility as in vitro surrogates of in vivo immunological control of M.tb. We evaluated a whole blood growth inhibition assay in a setting with high burden of TB and aimed to identify immune responses that correlate with control of mycobacterial growth. We hypothesized that individuals with underlying M.tb infection will exhibit greater M...
2017: PloS One
https://www.readbyqxmd.com/read/28879160/performance-of-xpert-%C3%A2-mtb-rif-among-tuberculosis-outpatients-in-lilongwe-malawi
#6
Tarsizio Chikaonda, Nelson Nguluwe, Brian Barnett, Runa H Gokhale, Robert Krysiak, Isaac Thengolose, Nora E Rosenberg, Christopher Stanley, James Mpunga, Irving F Hoffman, Mina Hosseinipour, Lesley Scott, Wendy Stevens
BACKGROUND: Xpert(®) MTB/RIF is a molecular test for the detection of Mycobacterium tuberculosis and rifampicin resistance. It is considered to be a great advance over smear microscopy and culture. However, there is very little information regarding the performance characteristics of Xpert MTB/RIF in Malawi. OBJECTIVE: We aimed to evaluate the performance of Xpert MTB/RIF in a Malawian setting. METHODS: Stored sputum pellets were processed on Xpert MTB/RIF between June 2012 and May 2014...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28879157/evaluation-of-the-sd-bioline-tb-ag-mpt64-test-for-identification-of-mycobacterium-tuberculosis-complex-from-liquid-cultures-in-southwestern-uganda
#7
Patrick Orikiriza, Dan Nyehangane, Daniel Atwine, John J Kisakye, Kennedy Kassaza, Juliet-Mwanga Amumpaire, Yap Boum
BACKGROUND: To confirm presence of Mycobacterium tuberculosis complex, some tuberculosis culture laboratories still rely on para-nitrobenzoic acid (PNB), a traditional technique that requires sub-culturing of clinical isolates and two to three weeks to give results. Rapid identification tests have improved turnaround times for mycobacterial culture results. Considering the challenges of the PNB method, we assessed the performance of the SD Bioline TB Ag MPT64 assay by using PNB as gold standard to detect M...
2017: African Journal of Laboratory Medicine
https://www.readbyqxmd.com/read/28841870/molecular-characterization-of-bovine-tuberculosis-strains-in-two-slaughterhouses-in-morocco
#8
Hind Yahyaoui-Azami, Hamid Aboukhassib, Mohammed Bouslikhane, Jaouad Berrada, Soukaina Rami, Miriam Reinhard, Sebastien Gagneux, Julia Feldmann, Sonia Borrell, Jakob Zinsstag
BACKGROUND: Bovine tuberculosis (BTB) is caused by Mycobacterium bovis, which belongs to the Mycobacterium tuberculosis complex. Mycobacterium bovis have been described to be responsible of most cases of bovine tuberculosis. Although M. tuberculosis, M. africanum and non-complex mycobacteria were isolated from cattle. In Morocco, so far, no molecular studies were conducted to characterize the strains responsible of BTB. The present study aims to characterize M. bovis in Morocco. The present study was conducted in slaughterhouses in Rabat and El Jadida...
August 25, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/28836691/disseminated-cutaneous-mycobacterium-kansasii-infection-presenting-with-rosai-dorfman-disease-like-histological-features-in-a-patient-carrying-anti-interferon-%C3%AE-autoantibodies
#9
Yih-An King, Chung-Hong Hu, Yuarn-Jang Lee, Chiou-Feng Lin, Donald Liu, Kuo-Hsien Wang
Typical cutaneous non-tuberculous mycobacteria (NTM) infections show a histopathology pattern of granulomas with admixed Langhans giant cells, and abscesses may be observed in acute lesions. Herein, we describe a patient carrying a high titer of autoantibodies to interferon (IFN)-γ with disseminated Mycobacterium kansasii infection presenting with emperipolesis and Rosai-Dorfman disease (RDD)-like histopathological features characterized by remarkable, large, pale-staining "RD cells", which were CD68 and S100 positive and CD1a negative...
August 24, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28835629/metabolic-activity-of-mature-biofilms-of-mycobacterium-tuberculosis-and-other-non-tuberculous-mycobacteria
#10
Anna Solokhina, David Brückner, Gernot Bonkat, Olivier Braissant
Mycobacteria are classified into two groups, fast- and slow-growing. Often, fast-growing mycobacteria are assumed to have a higher metabolic activity than their slower counterparts, but in mature biofilms this assumption might not be correct. Indeed, when measuring the metabolic activity of mycobacterial biofilms with two independent non-invasive techniques (isothermal microcalorimetry and tunable diode laser absorption spectrometry), mature biofilms of slow- and fast-growing species appeared more alike than expected...
August 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28820031/elimination-of-mycobacterium-chimaera-in-a-heater-cooler-device-used-during-on-pump-cardiothoracic-surgery
#11
Conny Nielsen, Conni L Winther, Philip K Thomsen, Jan J Andreasen
Since 2014, several infections with non-tuberculous mycobacteria (NTM) belonging to the species Mycobacterium ( M.) chimaera have been associated with the use of heater-cooler devices during on-pump cardiothoracic surgery both in European countries and the United States of America. Infections have been detected after surgery, with a delay of a few months and up to five years. Bacterial contamination of heater-cooler devices has also been described without any associated infections. In many centres, it has been a challenging task to eliminate NTM from the heater-cooler devices in order to reduce the risk to patients...
September 2017: Perfusion
https://www.readbyqxmd.com/read/28804763/effects-of-chest-physical-therapy-in-patients-with-non-tuberculous-mycobacteria
#12
Ashwin Basavaraj, Leopoldo Segal, Jonathan Samuels, Jeremy Feintuch, Joshua Feintuch, Kevin Alter, Daniella Moffson, Adrienne Scott, Doreen Addrizzo-Harris, Mengling Liu, David Kamelhar
Antibiotic therapy against non-tuberculous mycobacteria (NTM) is prolonged and can be associated with toxicity. We sought to evaluate whether chest physical therapy (PT) was associated with clinical improvement in patients with NTM not receiving anti-mycobacterial pharmacotherapy. A retrospective review of 77 subjects that were followed from June 2006 to September 2014 was performed. Baseline time point was defined as the first positive sputum culture for NTM; symptoms, pulmonary function, and radiology reports were studied...
2017: International Journal of Respiratory and Pulmonary Medicine
https://www.readbyqxmd.com/read/28804486/first-association-of-interleukin-12-receptor-beta-1-deficiency-with-sj%C3%A3-gren-s-syndrome
#13
Georgios Sogkas, Faranaz Atschekzei, Vivien Schacht, Christian von Falck, Alexandra Jablonka, Roland Jacobs, Matthias Stoll, Torsten Witte, Reinhold E Schmidt
INTRODUCTION: Interleukin 12 receptor beta 1 (IL12Rβ1) deficiency is a primary immunodeficiency resulting mainly in susceptibility to opportunistic infection by non-tuberculous, environmental mycobacteria and severe infection caused by Salmonella spp. Till now, less than 300 patients with IL12Rβ1 deficiency have been reported. Among them, only three have been described to develop autoimmunity. CASE PRESENTATION: We present the case of a 50-year-old male with IL12Rβ1 deficiency due to compound heterozygosity [c...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28771786/case-of-mycobacterium-haemophilum-misdiagnosed-as-mycobacterium-intracellulare-due-to-one-base-insertion-in-the-bacterial-genome
#14
Rika Nishikawa, Yozo Yamada, Haruhisa Kanki, Hiroshi Matsuoka, Tatsuya Nakamura, Takumi Jikimoto, Mari Kusuki, Norihisa Ishii, Kenichiro Ohnuma, Kazue Nakanaga, Chikako Nishigori
Mycobacterium haemophilum is a slow-growing, non-tuberculous mycobacteria that causes cutaneous infection. We describe a case of cutaneous infection in a 68-year-old Japanese man with polymyositis. This was caused by M. haemophilum harboring one base insertion in gene sequence. At first, the causal microorganism was misidentified as M. intracellulare by COBAS(®) TaqMan(®) MAI test. However, poor growth on Ogawa media and growth enhancement on 7H11C agar around a hemin-containing disk prompted us to reinvestigate the causal microorganisms, which were revealed to be M...
August 3, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28756809/first-report-in-china-on-the-identification-and-drug-sensitivity-of-mycobacterium-elephantis-isolated-from-the-milk-of-a-cow-with-mastitis
#15
Ling Yun Ji, Dong Lei Xu, Shu Peng Yin, Hai Can Liu, Gui Lian Li, Yi Jiang, Jian Hao Wei, Hao Zeng, Yong Liang Lou, Jian Xin Lyu, Kang Lin Wan
OBJECTIVE: In this study, milk from a cow with mastitis was analyzed to determine the presence of mycobacterial infection. Milk quality and security problems pertaining to the safe consumption of dairy products were also discussed in this study. METHODS: Milk was preprocessed with 4% NaOH. Then, mycobacteria were isolated from the milk sample on L-J medium. The isolate was identified using multiple loci Polymerase Chain Reaction (PCR) and multi-locus sequence analysis with 16S rRNA, sodA, hsp65, and ITS genes...
July 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28709494/multiple-abdominal-abscesses-a-not-so-common-presentation-of-ntm
#16
Darshan K Bajaj, R A S Kushwaha, Anand Srivastava, Mona Asnani
Non-tuberculous Mycobacteria/Mycobacterium other than tuberculosis (MOTT) are ubiquitous organisms. They are acid fast bacilli often giving trouble to the physician to distinguish it from Mycobacterium tuberculosis. These organisms are a menace for the treating physician as when to treat and when not to treat. They are often difficult to diagnose and may present in a variety of forms with propensity to cause number of infections of different body parts and organs. They are more common in immunocompromised individuals e...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28709485/biofilm-colonization-of-mycobacterium-abscessus-new-threat-in-hospital-acquired-surgical-site-infection
#17
Roumi Ghosh, Soumen Das, Harish Kela, Asmita De, Jayeeta Haldar, Prasanta Kumar Maiti
INTRODUCTION: Rapidly growing non-tuberculous mycobacteria (NTM) are hazardous cause of post-operative soft tissue infection leading to nosocomial outbreaks following various surgical procedures, especially laparoscopic surgeries using heat sensitive, non-autoclavable surgical instruments. METHODOLOGY: Surgery department of our hospital noticed increase in rate of post-laparoscopic abdominal port site infection (PSI) and informed the Microbiology Department. A prospective investigational study of defined cases with the aim of source tracing and formulation of infection control measures was initiated...
July 2017: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/28696241/ethambutol-partitioning-in-tuberculous-pulmonary-lesions-explains-its-clinical-efficacy
#18
Matthew Zimmerman, Jodi Lestner, Brendan Prideaux, Paul O'Brien, Isabela Dias-Freedman, Chao Chen, Jillian Dietzold, Isaac Daudelin, Firat Kaya, Landry Blanc, Pei-Yu Chen, Steven Park, Padmini Salgame, Jansy Sarathy, Véronique Dartois
Clinical trials and practice have shown that ethambutol is an important component of the first-line tuberculosis (TB) regime. This contrasts the drug's rather modest potency and lack of activity against nongrowing persister mycobacteria. The standard plasma-based pharmacokinetic-pharmacodynamic profile of ethambutol suggests that the drug may be of limited clinical value. Here, we hypothesized that this apparent contradiction may be explained by favorable penetration of the drug into TB lesions. First, we utilized novel in vitro lesion pharmacokinetic assays and predicted good penetration of the drug into lesions...
September 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28693908/pathology-of-pulmonary-tuberculosis-and-non-tuberculous-mycobacterial-lung-disease-facts-misconceptions-and-practical-tips-for-pathologists
#19
REVIEW
Deepali Jain, Subha Ghosh, Lucileia Teixeira, Sanjay Mukhopadhyay
Most pathologists are familiar with the microscopic features of tuberculosis and the need to examine special stains for acid-fast bacteria (AFB) in cases of granulomatous lung disease. However, misconceptions do exist, including the concept that finding AFB in "caseating granulomas" confirms the diagnosis of tuberculosis. This dogma is attributable to the high prevalence of tuberculosis in many countries, as well as unfamiliarity with the microscopic spectrum of non-tuberculous mycobacterial lung disease. This review aims to provide surgical pathologists with practical tips to identify AFB, illustrate the histologic overlap between pulmonary tuberculosis and non-tuberculous mycobacterial lung disease, and highlight the importance of cultures in this setting...
June 7, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/28688832/prosthetic-valve-infective-endocarditis-with-mycobacterium-fortuitum-antibiotics-alone-can-be-curative
#20
Sonali R Gnanenthiran, Eunice Y T Liu, Michael Wilson, Tommy Chung, Thomas Gottlieb
Rapidly growing non-tuberculous mycobacteria (RGM) are a rare, often fatal cause of infective endocarditis. Although surgery has been the cornerstone of RGM endocarditis therapy, we present the first documented adult case of Mycobacterium fortuitum endocarditis cured with antibiotic therapy.
June 15, 2017: Heart, Lung & Circulation
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