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https://www.readbyqxmd.com/read/28088766/staphylococcus-aureus-cc395-harbours-a-novel-composite-staphylococcal-cassette-chromosome-mec-element
#1
Jesper Larsen, Paal S Andersen, Volker Winstel, Andreas Peschel
BACKGROUND: CoNS species are likely reservoirs of the staphylococcal cassette chromosome mec (SCCmec) in Staphylococcus aureus S aureus CC395 is unique as it is capable of exchanging DNA with CoNS via bacteriophages, which are also known to mediate transfer of SCCmec OBJECTIVES: To analyse the structure and putative origin of the SCCmec element in S aureus CC395. METHODS: The only MRSA CC395 strain described in the literature, JS395, was subjected to WGS, and its SCCmec element was compared with those found in CoNS species and other S...
January 14, 2017: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/28088761/amplification-of-unscheduled-dna-synthesis-signal-enables-fluorescence-based-single-cell-quantification-of-transcription-coupled-nucleotide-excision-repair
#2
Franziska Wienholz, Wim Vermeulen, Jurgen A Marteijn
Nucleotide excision repair (NER) comprises two damage recognition pathways: global genome NER (GG-NER) and transcription-coupled NER (TC-NER), which remove a wide variety of helix-distorting lesions including UV-induced damage. During NER, a short stretch of single-stranded DNA containing damage is excised and the resulting gap is filled by DNA synthesis in a process called unscheduled DNA synthesis (UDS). UDS is measured by quantifying the incorporation of nucleotide analogues into repair patches to provide a measure of NER activity...
January 13, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28088154/vibrational-properties-of-anhydrous-and-partially-hydrated-uranyl-fluoride
#3
M C Kirkegaard, J Langford, J Steill, B Anderson, A Miskowiec
Uranyl fluoride (UO2F2) is a hygroscopic powder with two main structural phases: an anhydrous crystal and a partially hydrated crystal of the same R3¯m symmetry. The formally closed-shell electron structure of anhydrous UO2F2 is amenable to density functional theory calculations. We use density functional perturbation theory (DFPT) to calculate the vibrational frequencies of the anhydrous crystal structure and employ complementary inelastic neutron scattering and temperature-dependent Raman scattering to validate those frequencies...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088149/collective-excitations-in-liquid-dimethyl-sulfoxide-dmso-fir-spectrum-low-frequency-vibrational-density-of-states-and-ultrafast-dipolar-solvation-dynamics
#4
Milan K Hazra, Biman Bagchi
Valuable dynamical and structural information about neat liquid DMSO at ambient conditions can be obtained through a study of low frequency vibrations in the far infrared (FIR), that is, terahertz regime. For DMSO, collective excitations as well as single molecule stretches and bends have been measured by different kinds of experiments such as OHD-RIKES and terahertz spectroscopy. In the present work, we investigate the intermolecular vibrational spectrum of DMSO through three different computational techniques namely (i) the far-infrared spectrum obtained through the Fourier transform of total dipole moment auto-time correlation function, (ii) from the Fourier transform of the translational and angular velocity time autocorrelation functions, and (iii) a quenched normal mode analysis of the parent liquid at 300 K...
January 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28088071/discrete-quasi-linear-viscoelastic-damping-analysis-of-connective-tissues-and-the-biomechanics-of-stretching
#5
Behzad Babaei, Aaron J Velasquez-Mao, Stavros Thomopoulos, Elliot L Elson, Steven D Abramowitch, Guy M Genin
The time- and frequency-dependent properties of connective tissue define their physiological function, but are notoriously difficult to characterize. Well-established tools such as linear viscoelasticity and the Fung quasi-linear viscoelastic (QLV) model impose forms on responses that can mask true tissue behavior. Here, we applied a more general discrete quasi-linear viscoelastic (DQLV) model to identify the static and dynamic time- and frequency-dependent behavior of rabbit medial collateral ligaments. Unlike the Fung QLV approach, the DQLV approach revealed that energy dissipation is elevated at a loading period of ∼10s...
December 22, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28087342/myeloid-leukemia-factor-1-is-a-novel-modulator-of-neonatal-rat-cardiomyocyte-proliferation
#6
Ashraf Yusuf Rangrez, Jost Pott, Annika Kluge, Robert Frauen, Katharina Stiebeling, Phillip Hoppe, Samuel Sossalla, Norbert Frey, Derk Frank
The present study focuses on the identification of the gene expression profile of neonatal rat cardiomyocytes (NRVCMs) after dynamic mechanical stretch through microarrays of RNA isolated from cells stretched for 2, 6 or 24h. In this analysis, myeloid leukemia factor-1 (MLF1) was found to be significantly downregulated during the course of stretch. We found that MLF1 is highly expressed in the heart, however, its cardiac function is unknown yet. In line with microarray data, MLF1 was profoundly downregulated in in vivo mouse models of cardiomyopathy, and also significantly reduced in the hearts of human patients with dilated cardiomyopathy...
January 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28087265/myocardial-relaxation-is-accelerated-by-fast-stretch-not-reduced-afterload
#7
Charles S Chung, Charles W Hoopes, Kenneth S Campbell
Fast relaxation of cross-bridge generated force in the myocardium facilitates efficient diastolic function. Recently published research studying mechanisms that modulate the relaxation rate has focused on molecular factors. Mechanical factors have received less attention since the 1980s when seminal work established the theory that reducing afterload accelerates the relaxation rate. Clinical trials using afterload reducing drugs, partially based on this theory, have thus far failed to improve outcomes for patients with diastolic dysfunction...
January 10, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28081535/efficacy-and-safety-of-continuous-subcutaneous-infusion-of-recombinant-human-gonadotropins-for-congenital-micropenis-during-early-infancy%C3%A2
#8
Athanasia Stoupa, Dinane Samara-Boustani, Isabelle Flechtner, Graziella Pinto, Isabelle Jourdon, Laura González-Briceño, Maud Bidet, Kathleen Laborde, Didier Chevenne, Anne-Elodie Millischer, Henri Lottmann, Thomas Blanc, Yves Aigrain, Michel Polak, Jacques Beltrand
BACKGROUND: Early postnatal administration of gonadotropins to infants with congenital hypogonadotropic hypogonadism (CHH) can mimic minipuberty, thereby increasing penile growth. We assessed the effects of gonadotropin infusion on stretched penile length (SPL) and hormone levels in infants with congenital micropenis. METHODS: Single-center study including 6 males with micropenis in case of isolated CHH (n = 4), panhypopituitarism (n = 1), and partial androgen insensitivity syndrome (PAIS; n = 1)...
January 12, 2017: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/28081104/intracavity-stretcher-for-chirped-pulse-amplification-in-high-power-laser-systems
#9
Hartmut Liebetrau, Marco Hornung, Sebastian Keppler, Marco Hellwing, Alexander Kessler, Frank Schorcht, Joachim Hein, Malte C Kaluza
We present pulse stretching with an intracavity Offner-type pulse stretcher applied to a high-energy, short-pulse laser system. The compact intracavity design, offering a tunable stretching factor, allows the pulses to be stretched to several nanoseconds and, at the same time, to be amplified to 100 μJ. The stretched pulses have been further amplified with the high-power laser system Polaris and have been recompressed to durations as short as 102 fs, reaching peak powers of 100 TW. Furthermore, the temporal intensity contrast is investigated and compared to the formerly used stretcher setup...
January 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28081038/impact-of-hiv-infection-and-antiretroviral-treatment-on-n-terminal-prohormone-of-brain-natriuretic-peptide-as-surrogate-of-myocardial-function
#10
Christopher Schuster, Christina Binder, Robert Strassl, Maximilian C Aichelburg, Emma Blackwell, Noemi Pavo, Michael Ramharter, Martin Hülsmann, Katharina Grabmeier-Pfistershammer, Armin Rieger, Georg Goliasch
OBJECTIVE: Vasoactive cardiovascular hormones such as the N-terminal prohormone of brain natriuretic peptide (NT-proBNP) are produced upon ventricular stretch and play a central role in neurohumoral pathways of the heart regulating cardiovascular remodeling and volume homeostasis. The impact of HIV infection on these neurohumoral pathways of the heart and its potential reversibility by combinations of antiretroviral therapies remain unclear. METHODS: We assessed serum levels of NT-proBNP in 219 antiretroviral therapy-naïve HIV-infected patients with a normal cardiac and renal status at treatment initiation and after attainment of viremic control...
January 28, 2017: AIDS
https://www.readbyqxmd.com/read/28081005/mechanical-properties-and-failure-behavior-of-phosphorene-with-grain-boundaries
#11
V Sorkin, Y W Zhang
Using the density-functional tight-binding method, we studied the effect of grain boundaries on the mechanical properties and failure behavior of phosphorene. We found that the high-angle tilt boundaries with a higher density of (5∣7) defect pairs (oriented along the armchair direction) are stronger than the low-angle tilt boundaries with a lower defect density, and similarly the high-angle boundaries with a higher density of (4∣8) defect pairs (oriented along the zigzag direction) are stronger than the low-angle boundaries with a lower defect density...
January 12, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28080976/respiratory-modulation-of-startle-eye-blink-a-new-approach-to-assess-afferent-signals-from-the-respiratory-system
#12
André Schulz, Thomas M Schilling, Claus Vögele, Mauro F Larra, Hartmut Schächinger
Current approaches to assess interoception of respiratory functions cannot differentiate between the physiological basis of interoception, i.e. visceral-afferent signal processing, and the psychological process of attention focusing. Furthermore, they typically involve invasive procedures, e.g. induction of respiratory occlusions or the inhalation of CO2-enriched air. The aim of this study was to test the capacity of startle methodology to reflect respiratory-related afferent signal processing, independent of invasive procedures...
November 19, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28080033/solvent-templated-folding-of-perylene-bisimide-macrocycles-into-coiled-double-string-ropes-with-solvent-sensitive-optical-signatures
#13
Peter Spenst, Ryan M Young, Brian T Phelan, Michel Keller, Jakub Dostál, Tobias Brixner, Michael R Wasielewski, Frank Würthner
A series of semi-rigid perylene bisimide (PBI) macrocycles with varied ring size containing two to nine PBI chromophores were synthesized in a one-pot reaction and their photophysical properties were characterized by fluorescence, steady-state and transient absorption spectroscopy as well as femtosecond stimulated Raman spectroscopy. These macrocycles show solvent-dependent conformational equilibria and excited-state properties. In dichloromethane the macrocycles prevail in wide-stretched conformations and exhibit upon photoexcitation symmetry-breaking charge separation followed by charge recombination to triplet states, which photosensitize singlet oxygen formation...
January 12, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28079923/vibrational-circular-dichroism-of-a-2-5-diketopiperazine-dkp-peptide-evidence-for-dimer-formation-in-cyclo-ll-or-ld-diphenylalanine-in-the-solid-state
#14
Ariel Pérez-Mellor, Anne Zehnacker
The diastereomer diketopiperazine (DKP) peptides built on phenylalanine, namely, cyclo diphenylalanine LPhe-LPhe and LPhe-DPhe, were studied in the solid phase by vibrational circular dichroism (VCD) coupled to quantum chemical calculations. The unit structure of cyclo LPhe-LPhe in KBr pellets is a dimer bridged by two strong NH…O hydrogen bonds. The intense bisignate signature in the CO stretch region is interpreted in terms of two contributions arising from the free COs of the dimer and the antisymmetrical combination of the bound COs...
January 12, 2017: Chirality
https://www.readbyqxmd.com/read/28079757/pathogenesis-of-abdominal-pain-in-bowel-obstruction-role-of-mechanical-stress-induced-upregulation-of-nerve-growth-factor-in-gut-smooth-muscle-cells
#15
You-Min Lin, Yu Fu, John Winston, Ravi Radhakrishnan, Sushil K Sarna, Li-Yen M Huang, Xuan-Zheng Shi
Abdominal pain is one of the major symptoms in bowel obstruction (BO); its cellular mechanisms remain incompletely understood. We tested the hypothesis that mechanical stress in obstruction upregulates expression of nociception mediator nerve growth factor (NGF) in gut smooth muscle cells (SMC), and NGF sensitizes primary sensory nerve to contribute to pain in BO. Partial colon obstruction was induced with a silicon band implanted in the distal bowel of Sprague-Dawley rats. Colon-projecting sensory neurons in the dorsal root ganglia (DRG, T13 to L2) were identified for patch clamp and gene expression studies...
January 6, 2017: Pain
https://www.readbyqxmd.com/read/28079374/ultrafast-dynamics-of-hydrogen-bond-breaking-and-making-in-the-excited-state-of-fluoren-9-one-time-resolved-visible-pump-ir-probe-spectroscopic-study
#16
Rajib Ghosh, Aruna K Mora, Sukhendu Nath, Dipak K Palit
Fluoren-9-one (FL) molecule with a single hydrogen bond accepting site (C=O group) has been used as a probe for investigation of the dynamics of hydrogen bond in its lowest excited singlet (S1) state using subpicosecond time-resolved visible pump - IR probe spectroscopic technique. In hexafluoroisopropanol (HFIP), a strong hydrogen bond donating solvent, formation of FL-alcohol hydrogen bonded complex in the ground electronic (S0) state is nearly complete with negligible concentration of FL molecule remaining free in solution...
January 12, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28079357/tetra-carboxylated-azobenzene-polymer-supramolecular-assemblies-as-high-performance-multiresponsive-actuators
#17
Chengqun Qin, Yiyu Feng, Haoran An, Junkai Han, Chen Cao, Wei Feng
Multistimuli-responsive polymers are materials of emerging interest, but synthetically challenging. In this work, supramolecular assembly was employed as a facile and effective approach for constructing 3,3',5,5'-azobenzenetetracarboxylic acid (H4abtc)/poly(diallyldimethylammonium chloride) (PDAC) supramolecules. Structural transformations of H4abtc can be induced by light, mechanical force, and heat, and influenced by free volume. Thus, the fabricated freestanding H4abtc/PDAC film underwent bending/unbending movements upon treatment with light, humidity, or temperature, as asymmetric structural transformations on either side of the film generated asymmetric contraction/stretching forces...
January 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28079124/axisymmetric-rotational-stagnation-point-flow-impinging-radially-a-permeable-stretching-shrinking-surface-in-a-nanofluid-using-tiwari-and-das-model
#18
Natalia C Roşca, Ioan Pop
In this paper, the problem of normal impingement rotational stagnation-point flow on a radially permeable stretching sheet in a viscous fluid, recently studied in a very interesting paper, is extended to a water-based nanofluid. A similarity transformation is used to reduce the system of governing nonlinear partial differential equations to a system of ordinary differential equations, which is then solved numerically using the function bvp4c from Matlab. It is found that dual (upper and lower branch) solutions exist for some values of the governing parameters...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078410/effects-of-direct-current-electric-fields-on-lung-cancer-cell-electrotaxis-in-a-pmma-based-microfluidic-device
#19
Yaping Li, Tao Xu, Xiaomei Chen, Shin Lin, Michael Cho, Dong Sun, Mengsu Yang
Tumor metastasis is the primary cause of cancer death. Numerous studies have demonstrated the electrotactic responses of various cancer cell types, and suggested its potential implications in metastasis. In this study, we used a microfluidic device to emulate endogenous direct current electric field (dcEF) environment, and studied the electrotactic migration of non-small cell lung cancer cell lines (H460, HCC827, H1299, and H1975) and the underlying mechanisms. These cell lines exhibited greatly different response in applied dcEFs (2-6 V/cm)...
January 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28078355/-compression-therapy-of-venous-leg-ulcers-in-the-decongestion-phase
#20
REVIEW
J Dissemond, S Eder, S Läuchli, H Partsch, M Stücker, W Vanscheidt
Compression therapy is the basis for successful treatment in most patients with venous leg ulcers. Concerning compression therapy, the initial phase of decongestion and the following phase of maintenance should be differentiated. While in the maintenance phase (ulcer) stocking systems are now frequently recommended, in the decongestion phase compression bandages are mostly still used, which however are often inappropriately applied. In German-speaking countries, compression therapy with short-stretch bandages has a long tradition...
January 11, 2017: Medizinische Klinik, Intensivmedizin und Notfallmedizin
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