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https://www.readbyqxmd.com/read/28918024/antisense-oligonucleotide-mediated-removal-of-the-polyglutamine-repeat-in-spinocerebellar-ataxia-type-3-mice
#1
Lodewijk J A Toonen, Frank Rigo, Haico van Attikum, Willeke M C van Roon-Mom
Spinocerebellar ataxia type 3 (SCA3) is a currently incurable neurodegenerative disorder caused by a CAG triplet expansion in exon 10 of the ATXN3 gene. The resultant expanded polyglutamine stretch in the mutant ataxin-3 protein causes a gain of toxic function, which eventually leads to neurodegeneration. One important function of ataxin-3 is its involvement in the proteasomal protein degradation pathway, and long-term downregulation of the protein may therefore not be desirable. In the current study, we made use of antisense oligonucleotides to mask predicted exonic splicing signals, resulting in exon 10 skipping from ATXN3 pre-mRNA...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28917876/preparation-of-chitosan-hydroxyapatite-composite-mono-fiber-using-coagulation-method-and-their-mechanical-properties
#2
Takuma Okada, Yuta Nobunaga, Toshiisa Konishi, Tomohiko Yoshioka, Satoshi Hayakawa, Maria Ascensão Lopes, Toshiki Miyazaki, Yuki Shirosaki
Autograft has been carried out for anterior cruciate ligament (ACL) reconstruction surgery. However, it has negative aspect because patients lose their healthy ligaments from other part. We focus on a chitosan-hydroxyapatite (HAp) composite fiber as a scaffold of ligament regeneration. Chitosan- HAp composite fiber was made by using coagulation method. Chitosan-NaH2PO4 solution was coagulated with coagulation bath including calcium ion to get the mono-fiber and then treated with sodium hydroxide solution to form HAp in fiber matrix...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28917361/immediate-effects-of-pilates-based-therapeutic-exercise-on-postural-control-of-young-individuals-with-non-specific-low-back-pain-a-randomized-controlled-trial
#3
Susana Lopes, Christophe Correia, Gonçalo Félix, Mário Lopes, Ana Cruz, Fernando Ribeiro
OBJECTIVES: Low back pain affects the person's ability to keep balance, especially in challenging conditions. The purpose of this study was to determine the immediate effects of Pilates exercises on postural sway and dynamic balance of young individuals with non-specific low back pain. DESIGN: Controlled laboratory design. SETTINGS AND MAIN OUTCOME MEASURES: Forty-six participants with non-specific low back pain were randomized to a Pilates (n=23, 10 males; age: 21...
October 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28917163/raman-and-fourier-transform-infrared-spectroscopic-study-of-pyromorphite-vanadinite-solid-solutions
#4
Urszula Solecka, Tomasz Bajda, Justyna Topolska, Sylwia Zelek-Pogudz, Maciej Manecki
Due to the great range of the application fields for apatites, there is a strong need to complete the data set determining the properties of these minerals. In this study, Raman and Infrared spectra of the phases from pyromorphite Pb5(PO4)3Cl - vanadinite Pb5(VO4)3Cl series were investigated. Totally, 9 samples (2 end-members and 7 solid solutions of the series) were synthesized at 25°C and pH=3.5, and analyzed. In the Raman and Infrared spectra of the studied Pb-apatites, the bands typical for the vibrations in the PO4 and the VO4 tetrahedra appeared...
August 26, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28916836/modelling-the-deformation-of-the-elastin-network-in-aortic-valve
#5
Afshin Anssari-Benam, Andrea Bucchi
This paper is concerned with proposing a suitable structurally-motivated strain energy function for modelling the deformation of the elastin network within the aortic valve (AV) tissue. The AV elastin network is the main non-collagenous load-bearing component of the valve matrix and therefore, within the context of continuum-based modelling of the AV, it essentially serves as the contribution of the 'isotropic matrix'. To date, such function has mainly been considered as either a generic neo-Hookean term or a general exponential function...
September 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28916583/a-balance-and-proprioception-intervention-programme-to-enhance-combat-performance-in-military-personnel
#6
Shany Funk, T Jacob, D Ben-Dov, E Yanovich, O Tirosh, N Steinberg
BACKGROUND: Optimal functioning of the lower extremities under repeated movements on unstable surfaces is essential for military effectiveness. Intervention training to promote proprioceptive ability should be considered in order to limit the risk for musculoskeletal injuries. The aim of this study was to assess the effect of a proprioceptive intervention programme on static and dynamic postural balance among Israel Defense Forces combat soldiers. METHODS: Twenty-seven male soldiers, aged 18-20 years, from a physical fitness instructor's course, were randomly divided into two groups matched by age and army unit...
September 14, 2017: Journal of the Royal Army Medical Corps
https://www.readbyqxmd.com/read/28915856/exercise-prescription-for-patients-with-multiple-sclerosis-potential-benefits-and-practical-recommendations
#7
Farzin Halabchi, Zahra Alizadeh, Mohammad Ali Sahraian, Maryam Abolhasani
BACKGROUND: Multiple sclerosis (MS) can result in significant mental and physical symptoms, specially muscle weakness, abnormal walking mechanics, balance problems, spasticity, fatigue, cognitive impairment and depression. Patients with MS frequently decrease physical activity due to the fear from worsening the symptoms and this can result in reconditioning. Physicians now believe that regular exercise training is a potential solution for limiting the reconditioning process and achieving an optimal level of patient activities, functions and many physical and mental symptoms without any concern about triggering the onset or exacerbation of disease symptoms or relapse...
September 16, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28915750/near-infrared-spectroscopy-and-anharmonic-theory-of-the-h2o-ar1-2-cation-complexes
#8
J Philipp Wagner, David C McDonald, Michael A Duncan
Weakly bound complexes of the water radical cation with argon (H2O(+)Arn, n = 1,2) were generated by an electrical discharge/supersonic expansion and probed with mid- and near-infrared photodissociation spectroscopy in the 2050-4550 and 4850-7350 cm(-1) regions. To elucidate these spectra, these complexes were studied computationally at the CCSD(T) level including anharmonicity with the VPT2 method. The comparison between experiment and predicted spectra demonstrates that the VPT2 method is adequate to capture most of the vibrational band positions and their intensities...
September 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28915248/invasion-strategy-and-abiotic-activity-triggers-for-non-native-gobiids-of-the-river-rhine
#9
Jan Baer, Frank Hartmann, Alexander Brinker
The 24 hour activity patterns of three non-native gobiids (round goby Neogobius melanostomus, Western tubenose goby Proterorhinus semilunaris and bighead goby Ponticola kessleri) were assessed over 46 consecutive months between 2011 and 2014 from their occurrence in the cooling water intake of a nuclear power plant on the River Rhine, Germany. In total, 117717 gobiids were identified and classified. The occurrence of all three species varied strongly between sampling years, and species-specific activity triggers were identified...
2017: PloS One
https://www.readbyqxmd.com/read/28915039/a-first-principles-molecular-dynamics-study-of-the-solvation-shell-structure-vibrational-spectra-polarity-and-dynamics-around-a-nitrate-ion-in-aqueous-solution
#10
Sushma Yadav, Ashu Choudhary, Amalendu Chandra
A first-principles molecular dynamics study is presented for the structural, dynamical, vibrational, and dipolar properties of the solvation shell of a nitrate ion in deuterated water. A detailed description of the anisotropic structure of the solvation shell is presented through calculations of various structural distributions in different conical shells around the perpendicular axis of the ion. The nitrate ion-water dimer potential energies are also calculated for many different orientations of water. The average vibrational stretch frequency of OD modes in the solvation shell is found to be higher than that of other OD modes in the bulk, which signifies a weakening of hydrogen bonds in the hydration shell...
September 15, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28915000/ductile-glass-of-polyrotaxane-toughened-by-stretch-induced-intramolecular-phase-separation
#11
Kazuaki Kato, Kaito Nemoto, Koichi Mayumi, Hideaki Yokoyama, Kohzo Ito
A new class of ductile glasses is created from a thermoplastic polyrotaxane. The hard glass, which has a Young's modulus of 1 GPa, shows crazing, necking, and strain hardening with a total elongation of 330%. Stress concentration is prevented through a unique stretch-induced intramolecular phase separation of the cyclic components and the exposed backbone. In situ synchrotron X-ray scattering studies indicate that the backbone polymer chains slip through the cyclic components in the regions where the stress is concentrated...
September 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28914724/the-role-of-brain-structure-in-predicting-adherence-to-a-physical-activity-regimen
#12
Swathi Gujral, Edward McAuley, Lauren E Oberlin, Arthur F Kramer, Kirk I Erickson
OBJECTIVE: Physical activity is important for maintaining health throughout the lifespan. However, adherence to PA regimens is poor with approximately 50% of older adults terminating activity intervention programs within 6 months. In this study we tested whether gray matter volume and white matter microstructural integrity prior to the initiation of a PA intervention predicts PA adherence. METHODS: 159 adults aged 60-80 years were randomly assigned to a moderate-intensity aerobic walking condition or a non-aerobic stretching and toning condition...
September 13, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28914588/interstitial-telomeric-repeats-associated-dna-breaks
#13
Olga Shubernetskaya, Dmitry Skvortsov, Sergey Evfratov, Maria Rubtsova, Elena Belova, Olga Strelkova, Varvara Cherepaninets, Oxana Zhironkina, Alexey Olovnikov, Maria Zvereva, Olga Dontsova, Igor Kireev
During a cell's lifespan, DNA break formation is a common event, associated with many processes, from replication to apoptosis. Most of DNA breaks are readily repaired, but some are meant to persist in time, such as the chromosome ends, protected by telomeres. Besides them, eukaryotic genomes comprise shorter stretches of interstitial telomeric repeats. We assumed that the latter may also be associated with the formation of DNA breaks meant to persist in time. In zebrafish and mouse embryos, cells containing numerous breakage foci were identified...
September 15, 2017: Nucleus
https://www.readbyqxmd.com/read/28914388/diet-has-independent-effects-on-the-pace-and-shape-of-aging-in-drosophila-melanogaster
#14
C Ruth Archer, Ugofilippo Basellini, John Hunt, Stephen J Simpson, Kwang Pum Lee, Annette Baudisch
Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is unclear what biologically meaningful information this approach offers. Here, we determine how the amount and ratio of protein and carbohydrate ingested by female Drosophila melanogaster affects how much mortality risk increases over a time-standardised life-course (the shape of aging) and the tempo at which animals live and die (the pace of aging)...
September 15, 2017: Biogerontology
https://www.readbyqxmd.com/read/28914309/tetragonal-phase-of-cylinders-self-assembled-from-binary-blends-of-ab-diblock-and-a-b-n-star-copolymers
#15
Wenbo Jiang, Yicheng Qiang, Meijiao Liu, Weihua Li, Feng Qiu, An-Chang Shi
The phase behavior of binary blends composed of AB diblock and (A'B)n star copolymers is studied using the polymeric self-consistent field theory, focusing on the formation and stability of the stable tetragonal phase of cylinders. In general, cylindrical domains self-assembled from AB-type block copolymers are packed into a hexagonal array, although a tetragonal array of cylinders could be more favourable for lithography applications in microelectronics. The polymer blends are designed such that there is an attractive interaction between the A and A' blocks, which increases the compatibility between the two copolymers and thus suppresses the macroscopic phase separation of the blends...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28914060/nuclear-spin-symmetry-conservation-in-1-h2-16-o-investigated-by-direct-absorption-ftir-spectroscopy-of-water-vapor-cooled-down-in-supersonic-expansion
#16
Robert Georges, Xavier Michaut, Audrey Moudens, Manuel Goubet, Olivier Pirali, Pascale Soulard, Pierre Asselin, Therese R Huet, Pascale Roy, Martin Fournier, Andrey A Vigasin
We report the results of an experimental study related to the relaxation of the nuclear spin isomers of the water molecule in a supersonic expansion. Rovibrational lines of both ortho- and para- spin isomers were recorded in the spectral range of H2O stretching vibrations around 3700 cm(-1) using FTIR direct absorption. Water vapor seeded either in argon, helium, oxygen or in a mixture of oxygen and argon was expanded into vacuum through a slit nozzle. Partial water vapor pressure in the mixture varied in a wide range from 1...
September 15, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28913706/novel-pericatheter-retrograde-urethrogram-technique-is-a-viable-method-for-postoperative-urethroplasty-imaging
#17
Rachael D Sussman, F Cameron Hill, George E Koch, Versha Patel, Krishnan Venkatesan
PURPOSE: The purpose of this study is to describe our technique for pericatheter retrograde urethrogram (pcRUG) and to evaluate the utility of a pcRUG to detect a clinically significant leak after urethral reconstruction. METHODS: We retrospectively reviewed our prospective IRB-approved database of patients undergoing urethral reconstruction. pcRUG was performed at 3-4 weeks after surgery, in standardized fashion. Patients were placed in oblique position, and with the penis stretched, diluted contrast was instilled via an angiocatheter alongside the indwelling urethral catheter under dynamic fluoroscopy...
September 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28913535/stepwise-microhydration-of-aromatic-amide-cations-water-solvation-networks-revealed-by-the-infrared-spectra-of-acetanilide-h2o-n-clusters-n-%C3%A2-3
#18
Johanna Klyne, Matthias Schmies, Mitsuhiko Miyazaki, Masaaki Fujii, Otto Dopfer
The structure and activity of peptides and proteins strongly rely on their charge state and the interaction with their hydration environment. Here, infrared photodissociation (IRPD) spectra of size-selected microhydrated clusters of cationic acetanilide (AA(+), N-phenylacetamide), AA(+)-(H2O)n with n ≤ 3, are analysed by dispersion-corrected density functional theory calculations at the ωB97X-D/aug-cc-pVTZ level to determine the stepwise microhydration process of this aromatic peptide model. The IRPD spectra are recorded in the informative X-H stretch (νOH, νNH, νCH, amide A, 2800-3800 cm(-1)) and fingerprint (amide I-II, 1000-1900 cm(-1)) ranges to probe the preferred hydration motifs and the cluster growth...
September 15, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28913428/rubbery-electronics-and-sensors-from-intrinsically-stretchable-elastomeric-composites-of-semiconductors-and-conductors
#19
Hae-Jin Kim, Kyoseung Sim, Anish Thukral, Cunjiang Yu
A general strategy to impart mechanical stretchability to stretchable electronics involves engineering materials into special architectures to accommodate or eliminate the mechanical strain in nonstretchable electronic materials while stretched. We introduce an all solution-processed type of electronics and sensors that are rubbery and intrinsically stretchable as an outcome from all the elastomeric materials in percolated composite formats with P3HT-NFs [poly(3-hexylthiophene-2,5-diyl) nanofibrils] and AuNP-AgNW (Au nanoparticles with conformally coated silver nanowires) in PDMS (polydimethylsiloxane)...
September 2017: Science Advances
https://www.readbyqxmd.com/read/28912723/increased-hemodynamic-load-in-early-embryonic-stages-alters-myofibril-and-mitochondrial-organization-in-the-myocardium
#20
Madeline Midgett, Claudia S López, Larry David, Alina Maloyan, Sandra Rugonyi
Normal blood flow is essential for proper heart formation during embryonic development, as abnormal hemodynamic load (blood pressure and shear stress) results in cardiac defects seen in congenital heart disease (CHD). However, the detrimental remodeling processes that relate altered blood flow to cardiac malformation and defects remain unclear. Heart development is a finely orchestrated process with rapid transformations that occur at the tissue, cell, and subcellular levels. Myocardial cells play an essential role in cardiac tissue maturation by aligning in the direction of stretch and increasing the number of contractile units as hemodynamic load increases throughout development...
2017: Frontiers in Physiology
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