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Vitiligo treatment

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https://www.readbyqxmd.com/read/28099532/vitiligo-patients-experience-barriers-in-accessing-care
#1
Teresa Chen, Carmen Grau, Maria Suprun, Nanette B Silverberg
Vitiligo is a loss of pigment occurring in approximately 0.4% to 2% of the worldwide population. The aim of this study was to determine and characterize barriers to access of care in US patients with vitiligo. An Internet-based, deidentified survey consisting of 82 questions about topics including demographics, recommendations for care, and/or barriers to receiving recommended care was designed and distributed to member participants in an online vitiligo support community consisting of patients (and parents/guardians of adolescents)...
December 2016: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/28054375/effects-of-age-of-onset-on-disease-characteristics-in-non-segmental-vitiligo
#2
Berna Solak, Bahar Sevimli Dikicier, Nur C Cosansu, Teoman Erdem
In patients with vitiligo, the clinical and laboratory features of the disease may vary according to time of onset. This is addressed in the literature by only a few studies with conflicting results. The aim of this study was to determine the demographic and clinical features of patients with non-segmental vitiligo and to establish the association between vitiligo and autoimmune diseases with a focus on time of disease onset. A total of 224 vitiligo patients for whom complete medical records were available were evaluated retrospectively...
January 4, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28052277/unknown-primary-melanoma-worldwide-survey-on-clinical-management
#3
Simone Ribero, Riccardo Pampena, Veronique Bataille, Elvira Moscarella, Luc Thomas, Pietro Quaglino, Concetta Potenza, Alexander C J Van Akkooi, Alessandro Testori, Paul Nathan, Susana Puig, Iris Zalaudek, Giuseppe Argenziano, Caterina Longo
BACKGROUND: How to deal with melanoma of unknown primary (MUP) origin is a debated topic in the literature. OBJECTIVE: We performed a worldwide survey to inquire what clinical and investigational workup is performed as well as the physicians' perception of this disease. METHODS: A questionnaire was sent via mail to clinicians involved in melanoma care from December 2015 to April 2016 using the International Dermoscopy Society website. RESULTS: 119 physicians from 47 different countries answered the questionnaire...
January 5, 2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28029168/trends-in-regenerative-medicine-repigmentation-in-vitiligo-through-melanocyte-stem-cell-mobilization
#4
REVIEW
Stanca A Birlea, Gertrude-E Costin, Dennis R Roop, David A Norris
Vitiligo is the most frequent human pigmentary disorder, characterized by progressive autoimmune destruction of mature epidermal melanocytes. Of the current treatments offering partial and temporary relief, ultraviolet (UV) light is the most effective, coordinating an intricate network of keratinocyte and melanocyte factors that control numerous cellular and molecular signaling pathways. This UV-activated process is a classic example of regenerative medicine, inducing functional melanocyte stem cell populations in the hair follicle to divide, migrate, and differentiate into mature melanocytes that regenerate the epidermis through a complex process involving melanocytes and other cell lineages in the skin...
December 28, 2016: Medicinal Research Reviews
https://www.readbyqxmd.com/read/28024126/janus-kinase-jak-inhibitors-for-the-treatment-of-skin-and-hair-disorders-a-review-of-literature
#5
Aniseh Samadi, Saman Ahmad Nasrollahi, Ashkan Hashemi, Mansour Nassiri-Kashani, Alireza Firooz
Janus kinase family (JAKs) has recently attracted the attention of many researchers, and several JAK inhibitor drugs have been developed targeting different members of the JAK family. Tofacitinib and ruxolitinib are U.S. FDA approved drugs in this family approved for rheumatoid arthritis and myeloproliferative diseases, respectively. Dysregulation of JAK/STAT pathway is also involved in many skin diseases, specifically inflammatory disorders. We overview the JAK/STAT signaling pathway and its involvement in skin diseases...
December 26, 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28009316/-efficacy-of-combined-use-of-antioxidative-and-phototherapy-in-the-treatment-of-vitiligo
#6
N I Tsiskarishvili, A Katsitadze, N V Tsiskarishvili, Ts Tsiskarishvili, L Chitanava
Despite of numerous investigations, carried out practically in all countries of the world for the study of vitiligo and the search for its new effective therapies, pathogenic mechanisms of vitiligo are still poorly understood, and the proposed treatments are not perfect. One of the most accepted theories of the pathogenesis of vitiligo is an oxidative stress theory, according to which a series of biochemical anomalies cause oxidative stress, leading to accumulation of melanocytotoxic substances and inhibition of natural processes of detoxification with subsequent destruction of melanocytes in vitiligo focus...
November 2016: Georgian Medical News
https://www.readbyqxmd.com/read/28003945/autologous-epidermal-grafting-using-a-novel-negative-pressure-epidermal-harvesting-system-in-a-case-of-stable-vitiligo
#7
Aarthi Krishna, Vanathi Thirunavukkarasu, Paru Priyadarshini Navaneetha Krishnan, Nithya Gayathri Devi Danasekaran, Ratnavel Rajendrabose
Vitiligo is a common pigmentary disorder of the skin with a great amount of social stigma attached to it. Though various medical modalities are available for the treatment of stable vitiligo, surgical modality remains the treatment of choice for stable and localized vitiligo. The surgical options range from simple punch grafting to the recent epidermal harvesting methods using a negative pressure unit. Although successful use of multiple methods of epidermal grafting has been reported, most of them are cumbersome and time-consuming...
November 15, 2016: Curēus
https://www.readbyqxmd.com/read/27998025/effect-of-different-types-of-therapeutic-trauma-on-vitiligo-lesions
#8
Medhat El Mofty, Samia Esmat, Nahla Hunter, Heba M Mashaly, Dina Dorgham, Olfat Shaker, Sarah Ibrahim
New treatment modalities for vitiligo acting by changing certain cytokines and metalloproteinases are newly emerging. The aim of this work is to To assess the efficacy of trichloroacetic acid (TCA) chemical peel, dermapen, and fractional CO2 laser in treatment of stable non-segmental vitiligo and to detect their effects on IL-17 and MMP-9 levels. Thirty patients with stable vitiligo were recruited in a randomized controlled study. They were randomly categorized into three equal groups. Group 1: TCA peel, Group 2: dermapen machine, and Group 3: Fractional CO2 laser...
December 20, 2016: Dermatologic Therapy
https://www.readbyqxmd.com/read/27992083/melanocyte-protective-effect-of-afzelin-is-mediated-by-the-nrf2-are-signaling-pathway-via-gsk-3%C3%AE-inactivation
#9
Eunsun Jung, Jin Hee Kim, Mi Ok Kim, Sang Yeol Lee, Jongsung Lee
Vitiligo is an acquired condition characterized by depigmented, cutaneous lesions that result from the death of pigment-producing cells, melanocytes. The occurrence of oxidative stress has been proposed as a pathogenetic mechanism for melanocyte degeneration in vitiligo. Therefore, in this study, we investigated the cytoprotective effects of afzelin against oxidative stress and its mechanism of action in human epidermal melanocytes. We found that afzelin significantly inhibited hydrogen peroxide-induced cell death, cellular reactive oxygen species production, and lipid peroxidation in melanocytes...
December 19, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27992012/conduct-protocol-in-emergency-acute-adrenal-insufficiency
#10
Adil Bachir Fares, Rômulo Augusto Dos Santos
Introduction: Acute adrenal insufficiency or addisonian crisis is a rare comorbidity in emergency; however, if not properly diagnosed and treated, it may progress unfavorably. Objective: To alert all health professionals about the diagnosis and correct treatment of this complication. Method: We performed an extensive search of the medical literature using specific search tools, retrieving 20 articles on the topic. Results: Addisonian crisis is a difficult diagnosis due to the unspecificity of its signs and symptoms...
November 2016: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/27986135/a-double-blind-placebo-controlled-phase-ii-clinical-trial-to-evaluate-oral-simvastatin-as-a-treatment-for-vitiligo
#11
Stefan G Vanderweil, Shinya Amano, Wei-Che Ko, Jillian M Richmond, Michelle Kelley, Maryanne Makredes Senna, Andrea Pearson, Sandhya Chowdary, Celia Hartigan, Bruce Barton, John E Harris
No abstract text is available yet for this article.
January 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27981626/regression-of-nevi-after-candida-injection-for-the-treatment-of-verruca-vulgaris
#12
Emily Kollmann, David Cleaver, Lloyd Cleaver, Jonathan Cleaver
The most common treatment methods for verruca vulgaris are destructive methods that are often painful and treat individual verruca. Thus immune modulators, including Candida immunotherapy, are used to treat persistent recalcitrant and multiple verrucas simultaneously. Very few side effects are reported with Candida immunotherapy; they include vitiligo and now halo nevi. Physicians need to be aware of and discuss side effects with patients undergoing Candida immunotherapy.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27981622/successful-treatment-of-vitiligo-associated-with-vogt-koyanagi-harada-disease
#13
Michelle L Bayer, Yvonne E Chiu
Vogt-Koyanagi-Harada disease (VKH) is a rare multisystem disorder with cutaneous, ophthalmic, neurologic, and auditory manifestations. There is a paucity of published literature regarding the management of cutaneous features in VKH. We report a case of VKH-associated vitiligo responsive to topical corticosteroids and topical calcineurin inhibitors.
December 16, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27968928/ethnic-skin-kids-are-not-just-little-people
#14
Lisa Y Shen, Brandi M Kenner-Bell, Janelle Ricketts, Roopal V Kundu
There are numerous skin conditions that occur commonly in children with ethnic skin, including vitiligo, progressive macular hypomelanosis, pityriasis alba, acne keloidalis nuchae, pseudofolliculitis barbae, and keloids. Though these conditions occur in both children and adults, children may have different patterns of clinical presentation and response to therapy. In caring for such patients, important treatment considerations include side effects of systemic medications and tolerability of invasive procedures...
November 2016: Clinics in Dermatology
https://www.readbyqxmd.com/read/27955934/quality-of-life-in-adults-with-facial-port-wine-stains
#15
Solveig L Hagen, Katherine R Grey, Dorota Z Korta, Kristen M Kelly
BACKGROUND: Facial port-wine stains (PWS) are considered by some an aesthetic skin problem, yet impact on quality of life (QoL) has not been objectively documented. OBJECTIVE: We sought to (1) characterize the effect of PWS on QoL in adults, (2) to identify the clinical and demographic factors that affect QoL, and (3) to compare our results with QoL studies in other skin conditions. METHODS: In total, 244 adults with facial PWS completed an online QoL survey, which included the Skindex-29 instrument...
December 9, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27943234/immune-related-alopecia-areata-and-universalis-type-in-cancer-patients-receiving-immune-checkpoint-inhibitors
#16
A Zarbo, V R Belum, V Sibaud, S Oudard, M A Postow, J J Hsieh, R J Motzer, K J Busam, M E Lacouture
CTLA-4, PD-1, and PD-L1 monoclonal antibodies, commonly known as immune checkpoint inhibitors, are used for the treatment of various malignancies. The mechanism of action involves the inhibition of negative regulators of immune activation, which results in many patients developing immune-related adverse events (irAEs) including endocrinopathies, pneumonitis, colitis, hepatitis and dermatologic events. Dermatologic irAEs include maculopapular rash, pruritus, vitiligo, blistering disorders, mucocutaneous lichenoid eruptions, rosacea, and exacerbation of psoriasis...
December 11, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27941720/effectiveness-of-topical-corticosteroid-topical-calcineurin-inhibitors-and-combination-of-them-in-the-treatment-of-vitiligo
#17
P Roy, S K Saha, P C Paul, A K Reza, A K Nandi, S Sultana, S Saha, S M Akhter, S Khatun, M Habibunnahar
Vitiligo is an acquired pigmentary skin disorder which is disfiguring and difficult to treat. Cure and response rates for vitiligo are significantly lower. This study was conducted to evaluate the effectiveness of topical corticosteroid, topical calcineurin inhibitors (tacrolimus) and combination of them in the treatment of vitilligo in two tertiary care Hospital, in the Department of Dermatology and Venereology OPD (out patient department) in Mymensingh Medical College Hospital and Jahurul Islam Medical College Hospital, Bajitpur, Kishoregonj from January 2015 to December 2015...
October 2016: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/27932898/two-cases-of-vogt-koyanagi-harada-s-disease-in-sub-saharan-africa
#18
Tunji S Oluleye, Adekunle O Rotimi-Samuel, Adetunji Adenekan, Olubanke T Ilo, Folashade B Akinsola, Adeola O Onakoya, Olufisayo T Aribaba, Adebukunola Adefule-Ositelu, Kareem O Musa, Yele Oyefeso
Vogt-Koyanagi-Harada's (VKH) disease has been reported to be rare in sub-Saharan Africa. Two Nigerians with the disease are presented in this report. The first patient, a 32-year-old pregnant Nigerian woman presented with a 1-month history of bilateral blurring of vision, persistent headache, and alopecia. Presenting visual acuity was 1 m counting fingers in both eyes. Examination revealed vitiligo and poliosis with bilateral panuveitis as well as bilateral exudative retinal detachment. A clinical assessment of complete VKH disease was made...
2016: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/27930376/excimer-light-treatment-for-idiopathic-guttate-hypomelanosis-a-pilot-study
#19
Jennifer R S Gordon, Kellie E Reed, Katherine R Sebastian, Ammar M Ahmed
BACKGROUND: Idiopathic guttate hypomelanosis (IGH) is a commonly acquired benign leukoderma characterized by multiple discrete, hypo- or depigmented macules often on extremities that can be aesthetically undesirable for patients. This is the first study using excimer laser for treatment. OBJECTIVE: To determine the effectiveness of excimer laser for repigmentation of idiopathic guttate hypomelanosis. METHODS AND MATERIALS: In this longitudinal, split-body controlled, single-blinded pilot study, 6 patients were treated with excimer laser for 12 weeks using the vitiligo protocol...
December 2, 2016: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/27928544/vitiligo-treatment-in-ancient-iranian-medicine
#20
Mohammad Pourmand, Mohammad Asgharzadeh, Jalil Rashedi, Behroz Mahdavi Poor
No abstract text is available yet for this article.
August 2016: Iranian Journal of Public Health
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