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Vitiligo treatment

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https://www.readbyqxmd.com/read/27920496/fabrication-of-anti-vitiligo-ointment-containing-psoralea-corylifolia-in-vitro-and-in-vivo-characterization
#1
Irshad Hussain, Nisar Hussain, Abdul Manan, Abdur Rashid, Barkat Khan, Sattar Bakhsh
BACKGROUND: Vitiligo is a repugnant and odious dermatological malady of the time. It has an detrimental impact on the pigmentation of the human skin as a result of the destruction of cutaneous melanocytes. It affects 1%-2% of the population worldwide. Different therapeutic regimens have been deployed to treat vitiligo, but none of them could stand alone to be stated as a perfect cure. Recently, a change has been observed through novel experimental-designed optimization leading to the development of an anti-vitiligo ointment containing Psoralea corylifolia (PC) seed powder...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27912903/genital-vitiligo-like-hypopigmentation-after-treatment-with-5-imiquimod
#2
P García-Montero, J B Repiso Jiménez, M T Fernández Morano, M de Troya Martín
No abstract text is available yet for this article.
November 29, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27904182/comparative-study-of-efficacy-of-epidermal-melanocyte-transfer-versus-hair-follicular-melanocyte-transfer-in-stable-vitiligo
#3
Navya Donaparthi, Ajay Chopra
BACKGROUND: Vitiligo surgery has come up a long way from punch skin grafts to epidermal cell suspension and latest to the extracted hair follicle outer root sheath cell suspension (EHFORSCS) transplantation. The progressive development from one technique to the other is always on a quest for the best. In the latest development, EHFORSCS, which is an enriched source of follicular inactive melanocyte (melanocyte stem cells), seems to be a good addition to the prevailing cell-based therapies for vitiligo...
November 2016: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/27902928/effects-of-aqueous-extracts-of-ecliptae-herba-polygoni-multiflori-radix-praeparata-and-rehmanniae-radix-praeparata-on-melanogenesis-and-the-migration-of-human-melanocytes
#4
Ping Xu, Shulan Su, Cheng Tan, Ren-Sheng Lai, Zhong-Sheng Min
ETHNOPHARMACOLOGICAL RELEVANCE: Polygoni multiflori radix praeparata (PMRP), Ecliptae herba (EH) and Rehmanniae radix praeparata (RRP) are the most frequently-used herbs by Traditional Chinese Medicine practitioners for the treatment of vitiligo. Their abilities to stimulate melanogenesis, melanocyte migration and MITF (microphthalmia associated transcription factor) protein expression were evaluated in this study. MATERIALS AND METHODS: The effects of aqueous extracts of PMRP, EH and RRP on human melanocytes in vitro were examined by MTT assay, tyrosinase activity, melanin synthesis, migration assay and Western blot...
November 28, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27892744/evaluation-of-efficacy-and-safety-of-different-pembrolizumab-dose-schedules-in-treatment-of-non-small-cell-lung-cancer-and-melanoma-a-systematic-review
#5
Omar Abdel-Rahman
AIM: Pembrolizumab is a fully humanized anti-PD-1 agent currently approved for the treatment of advanced melanoma and pretreated non-small-cell lung cancer (NSCLC). OBJECTIVE: To assess the efficacy and safety of different dose schedules of pembrolizumab in the treatment of patients with advanced NSCLC and melanoma. Search method: MEDLINE database has been searched. Reference lists of original studies and review articles were checked for other related articles. SELECTION CRITERIA: Prospective clinical trials reporting the outcomes of more than one dose schedule of pembrolizumab in the treatment of advanced NSCLC and melanoma...
November 28, 2016: Immunotherapy
https://www.readbyqxmd.com/read/27878842/pharmacologic-treatment-of-vitiligo-in-children-and-adolescents-a-systematic-review
#6
REVIEW
Andreia Freire de Menezes, Fernanda Oliveira de Carvalho, Rosana S S Barreto, Bruno de Santana Silva, Saravanan Shanmugam, Ricardo Queiroz Gurgel, Adriano Antunes de Souza Araújo
BACKGROUND: The true pathogenic mechanism of vitiligo is still unknown. About half of the patients with this disease have onset before the age of 20 years, making it a serious dermatologic disorder in childhood. OBJECTIVES: The objective of this study was to review the literature in a systematic way and identify the main pharmacologic treatments and outcomes in children and adolescents with vitiligo. METHODS: Four databases-the National Library of Medicine (MEDLINE-PubMed), Web of Science, Scopus, and Latin American and Caribbean Health Sciences (LILACS)-were used for the search up to January 2015...
November 23, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27864868/repigmentation-in-vitiligo-position-paper-of-the-vitiligo-global-issues-consensus-conference-vgicc
#7
Emily Yiping Gan, Viktoria Eleftheriadou, Samia Esmat, Iltefat Hamzavi, Thierry Passeron, Markus Böhm, Tag Anbar, Boon Kee Goh, Cheng-Che Eric Lan, Harvey Lui, M Ramam, Noufal Raboobee, Ichiro Katayama, Tamio Suzuki, Davinder Parsad, Vaneeta Seth, Henry W Lim, Nanja van Geel, Sanjeev Mulekar, John Harris, Richard Wittal, Laila Benzekri, Yvon Gauthier, Prasad Kumarasinghe, Steven Tien Guan Thng, Caio Cesar Silva de Castro, Marwa Abdallah, Charlotte Vrijman, Marcel Bekkenk, Julien Seneschal, Amit G Pandya, Khaled Ezzedine, Mauro Picardo, Alain Taïeb
The Vitiligo Global Issues Consensus Conference (VGICC), through an international e-Delphi consensus, concluded that "repigmentation" and "maintenance of gained repigmentation" are essential core outcome measures in future vitiligo trials. This VGICC position paper addresses these core topics in two sections and includes an atlas depicting vitiligo repigmentation patterns and color match. The first section delineates mechanisms and characteristics of vitiligo repigmentation and the second summarizes the outcomes of international meeting discussions and two e-surveys on vitiligo repigmentation, which had been carried out over three years...
November 19, 2016: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/27852042/toxicity-profile-of-approved-anti-pd-1-monoclonal-antibodies-in-solid-tumors-a-systematic-review-and-meta-analysis-of-randomized-clinical-trials
#8
REVIEW
Ricardo Costa, Benedito A Carneiro, Mark Agulnik, Alfred W Rademaker, Sachin G Pai, Victoria M Villaflor, Massimo Cristofanilli, Jeffrey A Sosman, Francis J Giles
PURPOSE: Nivolumab and pembrolizumab are antibodies against the programmed-death-receptor- 1 (PD-1) which are associated with distinct immune related adverse effects (AEs). This meta-analysis of randomized clinical trials aims to summarize current knowledge regarding the toxicity profile of these agents. METHODS: PubMed search was conducted in February of 2016. The randomized trials needed to have at least one of the study arms consisting of nivolumab or pembrolizumab monotherapy and a control arm containing no anti-PD-1 therapy...
November 11, 2016: Oncotarget
https://www.readbyqxmd.com/read/27836331/subsequent-vitiligo-after-hematopoietic-stem-cell-transplantation-a-nationwide-population-based-cohort-study-from-korea
#9
Jung Min Bae, Kwang Hyun Choi, Han Mi Jung, Sook Young Kim, Miri Kim, Gyung Moon Kim, Dong Soo Yu, Young Bok Lee
BACKGROUND: Subsequent vitiligo after hematopoietic stem cell transplantation (HSCT) has been described sporadically in case series. OBJECTIVE: To investigate the incidence and risk factors of subsequent vitiligo after HSCT. METHODS: A nationwide, population-based cohort study was performed using the Korean National Health Insurance Claims Database from 2009 to 2013. All HSCT recipients who had undergone HSCT between 2010 and 2011 and not treatment for vitiligo in 2009 (to exclude preexisting active vitiligo) were included in the HSCT recipient group, and an age- and sex-matched control group without HSCT was also established...
November 8, 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27824586/persistently-curly-hair-phenotype-with-the-use-of-nivolumab-for-squamous-cell-lung-cancer
#10
Constantin A Dasanu, Scott M Lippman, Steven C Plaxe
Increasing use of programmed cell death protein 1/programmed cell death protein 1 ligand inhibition for the treatment of patients with various malignancies such as advanced lung cancer, kidney cancer, and melanoma has resulted in valuable clinical responses, along with the occurrence of new and often puzzling side effects. Known cutaneous effects of CTLA4 and programmed cell death protein 1/programmed cell death protein 1 ligand inhibitors include generalized pruritus, vitiligo, maculopapular lesions, and lichenoid skin eruptions...
October 18, 2016: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/27818365/fractional-co2-lasers-contribute-to-the-treatment-of-stable-non-segmental-vitiligo
#11
Jinping Yuan, Hongqiang Chen, Ru Yan, Shaoshan Cui, Yuan-Hong Li, Yan Wu, Xing-Hua Gao, Hong-Duo Chen
BACKGROUND: Stable non-segmental vitiligo is often resistant to conventional therapies. OBJECTIVES: The purpose of this study was to investigate the effect of three types of fractional lasers in the treatment of stable non-segmental vitiligo. MATERIALS & METHODS: Twenty patients were enrolled in the study. The vitiligo lesions of each patient were divided into four treatment parts, and all parts were treated with narrowband ultraviolet-B (NB-UVB)...
November 4, 2016: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/27813161/successful-treatment-of-vitiligo-on-the-scalp-of-a-9-year-old-girl-using-autologous-cultured-pure-melanocyte-transplantation
#12
Xin-Gang Wu, Ai-E Xu
Leukotrichia frequently accompanies vitiligo on hairy areas such as the scalp. Treatment with conventional medical therapy is usually unsuccessful because of deficiencies in the melanocyte reservoir. We describe transplantation of autologous cultured pure melanocytes for scalp vitiligo with leukotrichia in a 9-year-old girl, resulting in almost complete and stable repigmentation of skin and hair.
November 4, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27799808/the-psychosocial-impact-of-acne-vitiligo-and-psoriasis-a-review
#13
REVIEW
Catherine M Nguyen, Kourosh Beroukhim, Melissa J Danesh, Aline Babikian, John Koo, Argentina Leon
INTRODUCTION: Chronic skin conditions have been well reported to affect a patient's quality of life on multiple dimensions, including the psychosocial domain. Psychosocial is defined as the interrelation of social factors with an individual's thoughts and behavior. The assessment of the psychosocial impact of skin disease on a patient can help direct the dermatologists' treatment goals. To evaluate the psychosocial impact of skin disease, we conducted a review of the literature on three skin conditions with onsets at various stages of life: acne, vitiligo, and psoriasis...
2016: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/27787879/impact-of-hmgb1-on-melanocytic-survival-and-its-involvement-in-the-pathogenesis-of-vitiligo
#14
J Y Kim, E J Lee, J Seo, S H Oh
BACKGROUND: Vitiligo is attributable to loss of functional melanocytes and is the most common acquired depigmenting disorder. Oxidative stress and intense UV irradiation are known to aggravate this condition. The non-histone high mobility group box 1 (HMGB1) DNA binding protein is a physiologic activator of immune responses, cellular proliferation, and cell death. Although implicated in the pathogenesis of autoimmune diseases and cutaneous disorders, the precise role of HMGB1 in melanocytes has yet to be studied...
October 27, 2016: British Journal of Dermatology
https://www.readbyqxmd.com/read/27783153/epidermal-hydrogen-peroxide-is-not-increased-in-lesional-and-non-lesional-skin-of-vitiligo
#15
Mohammad Z Zailaie
It is widely believed that the loss of the epidermal melanocytes in vitiligo is basically due to excessive oxidative stress. Previous research work described abnormal elevation of the absolute concentration of the epidermal hydrogen peroxide (H2O2) in lesional and non-lesional skin of vitiligo. Based on this finding, our primary research objective was to use this feature as a screening marker in individuals at a great risk of developing vitiligo. Ninety-six patients of non-segmental vitiligo (NSV) of varying durations, skin phototypes, and treatment modalities (psoralen UVA-, narrow band UVB-treated) were recruited for this study...
October 25, 2016: Archives of Dermatological Research
https://www.readbyqxmd.com/read/27764715/understanding-mechanisms-of-autoimmunity-through-translational-research-in-vitiligo
#16
James P Strassner, John E Harris
Vitiligo is an autoimmune disease of the skin that leads to life-altering depigmentation and remains difficult to treat. However, clinical observations and translational studies over 30-40 years have led to the development of an insightful working model of disease pathogenesis: Genetic risk spanning both immune and melanocyte functions is pushed over a threshold by known and suspected environmental factors to initiate autoimmune T cell-mediated killing of melanocytes. While under cellular stress, melanocytes appear to signal innate immunity to activate T cells...
October 17, 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/27747240/adult-onset-vitiligo-multivariate-analysis-suggests-the-need-for-a-thyroid-screening
#17
L Lazzeri, R Colucci, A Cammi, F Dragoni, S Moretti
Background. There are limited epidemiological studies evaluating the effect of age at onset on disease features in vitiligo. Objectives. To identify factors associated with adult onset vitiligo in comparison with childhood onset vitiligo. Patients and Methods. We retrospectively collected medical records of 191 patients. Such records included clinical examination, personal and familial medical history, laboratory evaluations, concomitant vitiligo treatment and drug assumption. Results. 123 patients with a disease onset after the age of 40 (adult onset vitiligo) were compared with 68 patients who developed vitiligo before the age of 12 (childhood onset vitiligo)...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27745746/chemical-leukoderma-associated-with-methylphenidate-transdermal-system-data-from-the-us-food-and-drug-administration-adverse-event-reporting-system
#18
Carmen Cheng, Lois La Grenade, Ida-Lina Diak, Allen Brinker, Robert L Levin
OBJECTIVE: To identify and characterize cases of chemical leukoderma, an underrecognized adverse event, associated with the methylphenidate transdermal system (MTS) reported to the US Food and Drug Administration Adverse Event Reporting System (FAERS). STUDY DESIGN: We searched the Food and Drug Administration Adverse Event Reporting System for reports of chemical leukoderma associated with MTS, received by the Food and Drug Administration from April 6, 2006 to December 23, 2014...
October 10, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27739129/anti-pd1-induced-psoriasis-a-study-of-21-patients
#19
Julie Bonigen, Christine Raynaud-Donzel, José Hureaux, Nora Kramkimel, Astrid Blom, Géraldine Jeudy, Anne-Laure Breton, Thomas Hubiche, Christophe Bedane, Delphine Legoupil, Anne Pham-Ledard, Julie Charles, Maurice Pérol, Emilie Gérard, Patrick Combemale, Daphné Bonnet, Michèle-Léa Sigal, Emmanuel Mahé
Nivolumab (Opdivo(®) ), pembrolizumab (Keytruda(®) ), atezolizumab, and pidilizumabab are anti-PD1 monoclonal antibodies. Nivolumab is licensed in advanced melanoma and second-line therapy of advanced or metastatic non-small cell lung cancer. When activated, the programmed cell death (PD)-1 is implicated in the inhibition of the immune system. Anti-PD1 removes this inhibition and allows the immune system to control tumour cell progression.(1-4) Immune-mediated toxicity of this treatment have been reported, either organ-specific toxicities - i...
October 14, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27738425/profile-of-skin-disorders-in-unreached-hilly-areas-of-north-india
#20
Deepak Dimri, Venkatashiva Reddy B, Amit Kumar Singh
Background. The pattern of skin morbidity in an area depends on climate, geography, socioeconomic status, nutrition, genetics, and habits of the community. Objective. The objective of the present study was to describe the morbidity profile of patients attending dermatology outpatient department in a tertiary care centre of Garhwal hills, North India. Methodology. This is a record based study carried out using the morbidity registers. Patient details, diagnosis, and treatment provided by physicians were documented in the morbidity register...
2016: Dermatology Research and Practice
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