keyword
MENU ▼
Read by QxMD icon Read
search

Vitiligo treatment

keyword
https://www.readbyqxmd.com/read/29731587/suction-blister-epidermal-grafting-for-vitiligo-involving-angles-of-lip-experience-of-112-patients
#1
Bikash R Kar, Chinmoy Raj
Background: Lip vitiligo is usually resistant to medical modalities of treatment, and in all these cases, surgery offers a hope. Suction blister grafting (SBG) has been tried since long for lip vitiligo with high rate of success. There have been no long-term follow-up studies of patients with SBG at a difficult-to-treat site like angles of lip, which prompted us to conduct this study. Aims and Objectives: To assess the pigmentation rate and patient satisfaction of SBG on vitiligo involving angles of lip...
January 2018: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/29729115/tissue-expression-of-aquaporine-3-in-different-sites-of-vitiligo-an-immunohistochemical-study
#2
S M Esmat, O A Zeid, D M Abdel Halim, M T Fawzy, M Abdel Latif, V Lazarova, M Assaf
The role of epidermal keratinocytes in the pathogenesis of vitiligo has been ignored despite the fact that both melanocytes and keratinocytes form one functional and structural unit. Aquaporin3 (AQP3), a glycerol water channel expressed in epithelial tissue, is involved in the regulation of keratinocyte proliferation, cell migration, and has a potential role in hypopigmentation in vitiligo. Normally, acral skin differs significantly from non-acral skin. Acral skin shows significantly lower hair follicle density, melanocyte density, Langerhans cell (LC) density, epidermal MHCII expression...
May 5, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29723363/macrophage-migration-inhibitory-factor-as-an-incriminating-agent-in-vitiligo
#3
Azza Gaber Antar Farag, Mostafa Ahmed Hammam, Mona SalahEldeen Habib, Nada Farag Elnaidany, Mona Eaid Kamh
BACKGROUND: Vitiligo is an autoimmune skin disorder in which the loss of melanocytes is mainly attributed to defective autoimmune mechanisms and, lately, there has been more emphasis on autoinflammatory mediators. Among these is the macrophage migration inhibitory factor, which is involved in many autoimmune skin diseases. However, little is known about the contribution of this factor to vitiligo vulgaris. OBJECTIVE: To determine the hypothesized role of migration inhibitory factor in vitiligo via estimation of serum migration inhibitory factor levels and migration inhibitory factor mRNA concentrations in patients with vitiligo compared with healthy controls...
March 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29707867/combination-of-fractional-carbon-dioxide-laser-with-narrow-band-ultraviolet-b-to-induce-repigmentation-in-stable-vitiligo-a-comparative-study
#4
Noha Nabil Doghaim, Shereen Farouk Gheida, Rania Ahmed El-Tatawy, Dareen Abdelaziz Mohammed Ali
BACKGROUND: Despite the numerous treatment modalities available for vitiligo, responses to treatment are still unsatisfactory. For this reason, new treatment modalities and approaches are needed. OBJECTIVE: To evaluate the efficacy and safety of fractional carbon dioxide (CO2 ) laser therapy followed by narrow band ultraviolet-B (NB-UVB) phototherapy on stable resistant vitiligo. SUBJECTS AND METHODS: Thirty-two patients with stable bilateral vitiligo were enrolled...
April 30, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29704281/granulomatous-dermatitis-associated-with-ipilimumab-therapy-ipilimumab-associated-granulomatous-dermatitis
#5
Shelby L Kubicki, Macartney E Welborn, Naveen Garg, Phyu P Aung, Anisha B Patel
Ipilimumab is a human monoclonal antibody that targets cytotoxic T-lymphocyte-associated antigen (CTLA-4) approved for treatment of metastatic melanoma. The most commonly reported side effects are immune-related adverse events (irAEs), typically affecting the gastrointestinal tract and skin. The overall incidence of irAEs in ipilimumab patients is 64.2%, and cutaneous irAEs (CirAEs) were the most commonly reported at 44.7%.1 A wide variety of CirAEs has been reported, including pruritus, rash, vitiligo, and xerosis...
April 27, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29696968/melanosome-targeting-near-infrared-fluorescent-probe-with-large-stokes-shift-for-in-situ-quantification-of-tyrosinase-activity-and-assessing-drugs-effects-on-differently-invasive-melanoma-cells
#6
Manshu Peng, Yan Wang, Qiang Fu, Feifei Sun, Na Na, Jin Ouyang
Tyrosinase (TYR) plays a vital role in melanin biosynthesis and is widely regarded as a relatively specific marker for melanocytic lesions which involve vitiligo, malignant cutaneous melanoma, Parkinson's disease (PD), etc. However, the detection of TYR in living cells with fluorescent probes is usually interfered by diverse endogenous reactive oxygen species (ROS) and reactive nitrogen species (RNS). Herein, we synthesized a melanosome-targeting near-infrared (NIR) fluorescent probe (HB-NP) with a large Stokes shift (195 nm), achieving a highly sensitive and selective in situ detection for intracellular TYR, by incorporating m-hydroxybenzy moiety that recognizes TYR specifically and the morpholine unit which facilitates the probe accumulating in melanosome into salicyladazine skeleton...
April 26, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29696444/fractional-co-2-laser-contributes-to-the-treatment-of-non-segmental-vitiligo-as-an-adjunct-therapy-a-systemic-review-and-meta-analysis
#7
Yu-Jen Chiu, Cherng-Kang Perng, Hsu Ma
The treatment of stable non-segmental vitiligo is often challenging, which new therapies are being searched. Multiple clinical trials have proposed the benefits and safety of using fractional carbon dioxide (CO2 ) laser as an adjunct therapy to conventional treatments. This study aimed to evaluate the safety and efficacy of fractional carbon dioxide laser as a combination therapy to conventional treatments in patients with stable non-segmental vitiligo. A literature search using PubMed, EMBASE, and the Cochrane Library was performed for comparative studies among vitiligo patients treated with additional fractional CO2 laser...
April 26, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29678394/-dermatologic-toxicities-of-immune-checkpoint-inhibitors
#8
REVIEW
V Sibaud, S Boulinguez, C Pagès, L Riffaud, L Lamant, C Chira, S Boyrie, E Vigarios, E Tournier, N Meyer
The development of immune checkpoint inhibitors (monoclonal antibodies targeting PD-1/PD-L1 or CTLA-4) represents a significant advance in the treatment of multiple cancers. Given their particular mechanism of action, which involves triggering CD4+/CD8+ T-cell activation and proliferation, they are associated with a specific safety profile. Their adverse events are primarily immune-related, and can affect practically all organs. In this context, dermatological toxicity is the most common, though it mostly remains mild to moderate and does not require discontinuation of treatment...
April 17, 2018: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/29673776/topical-janus-kinase-inhibitors-a-review-of-applications-in-dermatology
#9
REVIEW
Anna-Marie Hosking, Margit Juhasz, Natasha Atanaskova Mesinkovska
BACKGROUND: Janus kinase inhibitors (JAKi) have attracted attention for their role in treating inflammatory disorders. This new class of biologics has the potential to significantly impact the field of dermatology, especially with the development of topical formulations. OBJECTIVE: To summarize published evidence on the efficacy, safety, and tolerability of topical JAKi in the treatment of inflammatory skin conditions. METHODS: This is a review of PubMed and Cochrane Library up until November 2017...
April 16, 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29664513/vitiligo-type-cutaneous-manifestation-of-chronic-graft-versus-host-disease-case-report
#10
Karla Gálvez, Paula Muñoz, Valentina Vera, Claudio Arce
INTRODUCTION: Graft-versus-host disease (GVHD) is caused by a pathologic and destructive response of the organism as a result of the interaction between donor immunocompetent T lymphocytes and the recipient tisular antigens. It's considered the most serious complication of hematopoietic stem cell transplantation, most frequently described after bone marrow transplantation (BMT). The skin is usually the first and most commonly affected organ, in both acute and chronic, with a variable clinical spectrum of presentation...
February 2018: Revista Chilena de Pediatría
https://www.readbyqxmd.com/read/29615444/home-interventions-and-light-therapy-for-the-treatment-of-vitiligo-hi-light-vitiligo-trial-study-protocol-for-a-randomised-controlled-trial
#11
Rachel H Haines, Kim S Thomas, Alan A Montgomery, Jane C Ravenscroft, Perways Akram, Joanne R Chalmers, Diane Whitham, Lelia Duley, Viktoria Eleftheriadou, Garry Meakin, Eleanor J Mitchell, Jennifer White, Andy Rogers, Tracey Sach, Miriam Santer, Wei Tan, Trish Hepburn, Hywel C Williams, Jonathan Batchelor
INTRODUCTION: Vitiligo is a condition resulting in white patches on the skin. People with vitiligo can suffer from low self-esteem, psychological disturbance and diminished quality of life. Vitiligo is often poorly managed, partly due to lack of high-quality evidence to inform clinical care. We describe here a large, independent, randomised controlled trial (RCT) assessing the comparative effectiveness of potent topical corticosteroid, home-based hand-held narrowband ultraviolet B-light (NB-UVB) or combination of the two, for the management of vitiligo...
April 3, 2018: BMJ Open
https://www.readbyqxmd.com/read/29606833/disseminated-superficial-actinic-porokeratosis-in-a-vitiligo-patient-undergoing-treatment-with-long-term-narrowband-ultraviolet-b
#12
Eun-Jae Shin, Min Jae Gwak, Ki-Heon Jeong, Mu-Hyoung Lee
No abstract text is available yet for this article.
April 2018: Annals of Dermatology
https://www.readbyqxmd.com/read/29605863/increased-tenascin-c-and-dkk1-in-vitiligo-possible-role-of-fibroblasts-in-acral-and-non-acral-disease
#13
Samia M Esmat, Heba H El Hadidi, Rehab A Hegazy, Heba I Gawdat, Amira M Tawdy, Marwa M Fawzy, Dalia M AbdelHalim, Omnia S Sultan, Olfat G Shaker
Recently, multiple culprits-in addition to melanocytes-have been implicated in the pathogenesis of vitiligo. Among those factors are fibroblasts. However, their exact role has not been clearly elucidated. The aim of the study was to evaluate the possible role played by fibroblasts in vitiligo via studying the expression Tenascin C and DKK1 in acral versus non-acral vitiligo lesions. This case-control study included 19 non-segmental vitiligo patients and ten controls. All patients were subjected to thorough clinical evaluation...
March 31, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29581746/utility-of-dermoscopy-for-evaluating-the-therapeutic-efficacy-of-tacrolimus-ointment-plus-308-nm-excimer-laser-combination-therapy-in-localized-vitiligo-patients
#14
Lu-Mei Wang, Wan-Jiao Lu, Jing-Tao Yuan, Bi-Bing Zeng, Dan Li, Feng Zhang, Jun-Jie Li
The aim of the present study was to assess the function of dermoscopy in evaluating the therapeutic efficacy of tacrolimus ointment plus 308-nm excimer laser combination therapy in patients with localized vitiligo. A total of 147 patients with localized vitiligo (progressive disease, n=92; stable period, n=55) were enrolled and received combination therapy for 12 weeks. The condition of the skin lesions was monitored by dermoscopy and visual observation. At the initial visit, skin lesions were observed in 61 progressive and 19 stable patients...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29573480/the-role-of-phototherapy-in-the-surgical-treatment-of-vitiligo-a-systematic-review
#15
REVIEW
J E Lommerts, S E Uitentuis, M W Bekkenk, M A de Rie, A Wolkerstorfer
Vitiligo is frequently treated with the combination of phototherapy and melanocyte transplantation. However, the additional benefit of phototherapy is unclear. Moreover, the optimal type and regimen of phototherapy is unknown. The objective of this systematic review was to identify whether phototherapy improves the outcome of melanocyte transplantation in vitiligo. We searched and screened for eligible studies in the databases of MEDLINE, EMBASE and CENTRAL. We included all clinical studies investigating melanocyte transplantation combined with phototherapy...
March 24, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29560584/in-vitro-tyrp-1-knockdown-based-on-sirna-carried-by-liquid-crystalline-nanodispersions-an-alternative-approach-for-topical-treatment-of-vitiligo
#16
Larissa Bueno Tofani, Lívia Vieira Depieri, Patrícia Mazureki Campos, Thalita Bachelli Riul, Kamilla Swiech Antonietto, Márcia Carvalho de Abreu Fantini, Maria Vitória Lopes Badra Bentley
PURPOSE: Vitiligo is a skin disease characterized by depigmentation and the presence of white patches that are associated with the loss of melanocytes. The most common explanation for the cause of this condition is that it is an autoimmune condition. TyRP-1 is involved in melanin pigment synthesis but can also function as a melanocyte differentiation antigen. This protein plays a role in the autoimmune destruction of melanocytes, which results in the depigmentation, characteristic of this disease...
March 20, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29545869/the-effects-of-phototherapy-and-melanocytes-on-keratinocytes
#17
Luyan Tang, Wenyu Wu, Wenwen Fu, Yao Hu
Phototherapy is widely used in the treatment of vitiligo. Previous studies have focused on the effects of ultraviolet (UV) radiation on melanocytes; however, the biological effects of phototherapy and melanocytes on keratinocytes remain to be elucidated. To investigate and assess the effects of clinically doses of broad band (BB)-UVA, narrow band (NB)-UVB and melanocytes on human keratinocytes in vitro , clinical doses of BB-UVA or NB-UVB radiation and human melanoma cell A375 co-culture were performed as stress divisors to HaCaT cells...
April 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29533483/cutaneous-carcinogenic-risk-evaluation-in-375-patients-treated-with-narrowband-uvb-phototherapy-a-15-year-experience-from-our-institute
#18
Beatrice Raone, Annalisa Patrizi, Carlotta Gurioli, Andrea Gazzola, Giulia Maria Ravaioli
BACKGROUND: Narrowband-ultraviolet B (NB-UVB) is widely used for the treatment of several dermatological diseases. A cutaneous carcinogenic effect has been hypothesized, but not proved. METHODS: We retrospectively reviewed the data of patients treated with NB-UVB between January 1998 and December 2013 at the Dermatology Unit of our University Hospital, to evaluate the cutaneous carcinogenic risk of NB-UVB. RESULTS: In all, 375 patients were included, each receiving a mean follow-up of 6...
March 13, 2018: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/29532621/comparison-between-the-efficacy-of-microneedling-combined-with-5-fluorouracil-vs-microneedling-with-tacrolimus-in-the-treatment-of-vitiligo
#19
Mary Mina, Lamia Elgarhy, Hanan Al-Saeid, Zeinab Ibrahim
BACKGROUND: Several treatment modalities had been used for the treatment of vitiligo, but the optimal treatment has not yet been identified. OBJECTIVES: To study the efficacy of microneedling with 5-flurouracil vs its efficacy with tacrolimus in the treatment of vitiligo. PATIENTS AND METHODS: Twenty-five patients with vitiligo were subjected to microneedling of 2 patches of vitiligo with dermapen, then application of 5-fluorouracil to 1 patch and tacrolimus on the other patch...
March 12, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29524288/effect-of-narrow-band-ultraviolet-b-on-the-serum-of-25-hydroxyvitamin-d-in-vitiligo-patients
#20
Hassan Ibrahim, Moustafa El Taieb, Zeinab El Gamel, Abdel Rahman El Saied
BACKGROUND: Narrow-band ultraviolet B (NB-UVB) is the gold standard in the treatment of vitiligo. 25-hydroxyvitamin D (25-OH- vitamin D) might play a physiological role in photo-induced melanogenesis in human skin so the association between vitamin D levels and vitiligo still needs to be investigated more thoroughly. OBJECTIVE: we aim to investigate the influence of cumulative doses of NB-UVB phototherapy on vitamin D in patients with vitiligo and their correlation with NB-UVB-induced pigmentation...
March 10, 2018: Journal of Cosmetic Dermatology
keyword
keyword
28314
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"