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Vitiligo treatment

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https://www.readbyqxmd.com/read/28640738/evaluation-of-the-effect-and-mechanism-of-action-of-local-phenytoin-in-treatment-of-vitiligo
#1
Asmaa Gaber Abdou, Mohammed Abdelwahed Gaber, Nada Farag Elnaidany, Ayat Elnagar
There are many theories explaining vitiligo such as genetic, autoimmune, neural, free radicals, biochemical, intrinsic defect, melanocytorrhagy and convergent theories. Phenytoin is a widely used anticonvulsant, which is used in cutaneous medicine for treatment of ulcers and epidermolysis bullosa. The aim of this study is to assess the effectiveness of topical phenytoin gel in treatment of vitiligo patients and explaining the underlying mechanism using immunohistochemistry for evaluation of HMB45, CD4 and CD8...
June 22, 2017: Journal of Immunoassay & Immunochemistry
https://www.readbyqxmd.com/read/28634815/autoimmune-diabetes-induced-by-pd-1-inhibitor-retrospective-analysis-and-pathogenesis-a-case-report-and-literature-review
#2
Marie-Léa Gauci, Pauline Laly, Tiphaine Vidal-Trecan, Barouyr Baroudjian, Jérémy Gottlieb, Nika Madjlessi-Ezra, Laetitia Da Meda, Isabelle Madelaine-Chambrin, Martine Bagot, Nicole Basset-Seguin, Cécile Pages, Samia Mourah, Philippe Boudou, Céleste Lebbé, Jean-François Gautier
Anti-PD-1 antibody treatment is approved in advanced melanoma and provides median overall survival over 24 months. The main treatment-related side effects are immune-related adverse events, which include rash, pruritus, vitiligo, thyroiditis, diarrhoea, hepatitis and pneumonitis. We report a case of autoimmune diabetes related to nivolumab treatment. A 73-year-old man was treated in second line with nivolumab at 3 mg/kg every two weeks for metastatic melanoma. At 6 weeks of treatment, he displayed diabetic ketoacidosis...
June 20, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28627461/8-methoxypsoralen-reduces-akt-phosphorylation-induces-intrinsic-and-extrinsic-apoptotic-pathways-and-suppresses-cell-growth-of-sk-n-as-neuroblastoma-and-sw620-metastatic-colon-cancer-cells
#3
Magdalena Bartnik, Adrianna Sławińska-Brych, Aleksandra Żurek, Martyna Kandefer-Szerszeń, Barbara Zdzisińska
ETHNOPHARMACOLOGICAL RELEVANCE: 8-methoxypsoralen (8-MOP) is a furanocoumarin and an active compound of a traditional Egyptian medicinal plant Ammi majus L, whose juice/fruit has been used for many years in folk phototherapy for the treatment of vitiligo or a hyperproliferative skin disorder, psoriasis. 8-MOP together with UVA light is also used as an anticancer drug for the treatment of cutaneous T-cell lymphoma. However, furanocoumarins exert anticancer activity even without UV irradiation...
June 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28620923/home-phototherapy-in-vitiligo
#4
REVIEW
Tasneem F Mohammad, Narumol Silpa-Archa, James L Griffith, Henry W Lim, Iltefat H Hamzavi
Vitiligo is a disorder characterized by the development of depigmented macules and patches. Narrowband ultraviolet B phototherapy is a standard of care treatment and is used both as monotherapy and in combination with other treatment modalities to induce repigmentation. Although phototherapy is safe and effective, its use is limited due to the significant time commitment required and associated costs. Home phototherapy is a safe and effective alternative to make phototherapy more accessible to patients. However, it is often underutilized due to lack of physician experience and comfort as well as misconceptions regarding its safety and efficacy...
June 16, 2017: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28619557/current-and-emerging-treatments-for-vitiligo
#5
REVIEW
Michelle Rodrigues, Khaled Ezzedine, Iltefat Hamzavi, Amit G Pandya, John E Harris
Clinicians should be aware that vitiligo is not merely a cosmetic disease and that there are safe and effective treatments available for vitiligo. It is important to recognize common and uncommon presentations and those with active disease, as well as their implications for clinical management; these were discussed in the first article in this continuing medical education series. Existing treatments include topical and systemic immunosuppressants, phototherapy, and surgical techniques, which together may serve to halt disease progression, stabilize depigmented lesions, and encourage repigmentation...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28619550/new-discoveries-in-the-pathogenesis-and-classification-of-vitiligo
#6
REVIEW
Michelle Rodrigues, Khaled Ezzedine, Iltefat Hamzavi, Amit G Pandya, John E Harris
Vitiligo is a common autoimmune disease that progressively destroys melanocytes in the skin, resulting in the appearance of patchy depigmentation. This disfiguring condition frequently affects the face and other visible areas of the body, which can be psychologically devastating. The onset of vitiligo often occurs in younger individuals and progresses for life, resulting in a heavy burden of disease and decreased quality of life. Presentation patterns of vitiligo vary, and recognition of these patterns provides both diagnostic and prognostic clues...
July 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28587417/a-comparative-study-for-the-short-term-effects-of-targeted-high-intensity-uvb-and-narrow-band-uvb-in-the-treatment-of-vitiligo
#7
Min Zhang, Wei-Yuan Ma
Vitiligo is a common acquired depigmentation disorder for which many treatments have previously been used with varying effects. The aim of the present study was to evaluate the efficacy and safety of targeted high-intensity (TH) and narrow band (NB) ultraviolet B light (UVB) for vitiligo treatment. A total of 33 patients with vitiligo were enrolled in the present study. Patients with a symmetrical or near-symmetrical distribution of lesions on their bodies were selected for the present study. For each patient, half of the body was treated with TH-UVB and the other with NB-UVB twice weekly over a period of 12 weeks (24 times total)...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28581823/importance-of-light-in-the-treatment-of-vitiligo-with-jak-inhibitors
#8
Deep Joshipura, Natalia Plotnikova, Ari Goldminz, Sandhya Deverapalli, Yana Turkowski, Alice Gottlieb, David Rosmarin
Vitiligo is an autoimmune pigmentary disorder characterized by depigmented patches of skin with a selective loss of melanocytes. Recent advances describe vitiligo as a T-helper (Th1) cell-mediated disease with elevated levels of IFN-γ and its associated chemokines CXCL9 and CXCL10 responsible for depigmentation. The Janus kinase (JAK) inhibitors have shown promise for the treatment of vitiligo with improved response in the sun-exposed areas. We propose viewing the treatment of vitiligo as a two-step process where the first part involves suppressing the immune system, followed by stimulation of the melanocytes to repigment the affected areas...
June 5, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28579215/-vogt-koyanagi-harada-disease
#9
REVIEW
C Bonnet, J-B Daudin, D Monnet, A Brézin
Vogt-Koyanagi-Harada (VKH) disease is defined as a severe bilateral, chronic granulomatous panuveitis associated with serous retinal detachments, disk edema, and vitritis, with central nervous system, auditory, and integumentary manifestations. It is an autoimmune inflammatory condition mediated by T cells that target melanocytes in individuals genetically susceptible to the disease. Vogt-Koyanagi-Harada disease presents clinically in 4 different phases: prodromal, acute inflammatory, chronic, and recurrent, with extraocular manifestations including headache, meningitis, hearing loss, poliosis, and vitiligo...
May 31, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28577948/vitiligo-in-a-patient-with-lung-adenocarcinoma-treated-with-nivolumab-a-case-report
#10
Takeshi Uenami, Yuki Hosono, Mikako Ishijima, Masaki Kanazu, Yuki Akazawa, Yukihiro Yano, Masahide Mori, Toshihiko Yamaguchi, Soichiro Yokota
Nivolumab, an anti-programmed cell death-1 protein monoclonal antibody, is effective for treating patients with late-stage non-small-cell lung cancer. Immune checkpoint inhibitors such as nivolumab induce various kinds of immune-related adverse events, including vitiligo. Vitiligo has been reported in patients with melanoma but not lung cancer. We describe a 75-year-old man with lung adenocarcinoma, stage 4 with pleural and pericardial effusion, that progressed after first-line chemotherapy. Subsequently, he was treated with nivolumab as second-line therapy...
July 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28577207/vitiligo-an-update-on-pathophysiology-and-treatment-options
#11
REVIEW
Reinhart Speeckaert, Nanja van Geel
The pathophysiology of vitiligo is becoming increasingly clarified. In non-segmental vitiligo, early factors include activation of innate immunity, inflammasome activation, oxidative stress, and loss of melanocyte adhesion. Nonetheless, the main mechanism leading to non-segmental vitiligo involves an immune-mediated destruction of melanocytes. Anti-melanocyte-specific cytotoxic T cells exert a central role in the final effector stage. Genetic research revealed a multi-genetic inheritance displaying an overlap with other autoimmune disorders...
June 2, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28555441/alopecia-areata-of-the-beard-a-review-of-the-literature
#12
REVIEW
Jessica Cervantes, Raymond M Fertig, Austin Maddy, Antonella Tosti
Alopecia areata (AA) is a T-cell mediated autoimmune disorder in which inflammatory cells attack the hair follicle, resulting in round, well-circumscribed patches of noncicatricial hair loss in normal appearing skin. AA affecting the beard area is well known and is referred to as AA of the beard (BAA) or AA barbae when involvement is limited exclusively to the beard. BAA has been documented in a select number of studies. We review the literature and discuss the clinical features, epidemiology, diagnosis, and treatment of BAA...
May 29, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28544808/the-first-transepidermal-transplantation-of-non-cultured-epidermal-suspension-using-a-dermarolling-system-in-vitiligo-a-sequential-histological-and-clinical-study
#13
L Benzekri, Y Gauthier
The current methods for melanocyte delivery to depigmented skin are invasive and often require sophisticated approaches. Here we describe a promising simple and minimally invasive technique based on the dermarolling system. The technique involves preparation of a keratinocyte/melanocyte suspension prepared by trypsinization from a non-lesioned part of a patient's scalp skin and transepidermal delivery using a dermaroller equipped with 0.2 mm needles. Dermarolling leads to epidermal microinjuries without, however, causing pain or inflammation...
May 19, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/28543699/immune-and-molecular-correlates-in-melanoma-treated-with-immune-checkpoint-blockade
#14
REVIEW
Elizabeth H Byrne, David E Fisher
Immunotherapy for metastatic melanoma has a decades-long history, and the relatively recent use of checkpoint inhibitors has revolutionized treatment. Durable and sometimes complete remission of metastatic melanoma is now achievable in some patients who receive checkpoint-blocking therapy. However, it is unclear why some patients fare better than others. This review highlights several molecular indicators of response to checkpoint inhibition in metastatic melanoma, focusing on tumor programmed death ligand 1 expression, major histocompatibility complex class I expression, mutational load in the tumor, and T-cell infiltration into the tumor...
June 1, 2017: Cancer
https://www.readbyqxmd.com/read/28538030/efficacy-of-cyclosporine-after-autologous-noncultured-melanocyte-transplantation-in-localized-stable-vitiligo-a-pilot-open-label-comparative-study
#15
Sharad Mutalik, Swapnil Shah, Varsha Sidwadkar, Meenaz Khoja
BACKGROUND: Understanding the pathogenesis of vitiligo has lead to innovation of new drugs and new uses of the existing drugs to enhance treatment outcome. OBJECTIVE: The aim of this observational pilot study was to assess the role of cyclosporine (CsA) to tackle the commonest aesthetic problem "perilesional halo" after autologous noncultured melanocyte-keratinocyte cell transplant (NCMKT) for localized, stable vitiligo. MATERIALS AND METHODS: Of the total 50 enrolled patients who underwent NCMKT for stable/resistant vitiligo, aged 12 to 68 years (mean 29...
May 22, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28537890/protective-effect-of-madecassoside-on-h2o2-induced-oxidative-stress-and-autophagy-activation-in-human-melanocytes
#16
Yuting Ling, Qingli Gong, Xixi Xiong, Li Sun, Wene Zhao, Wenyuan Zhu, Yan Lu
BACKGROUND: Centella asiatica (L.) Urb. is a traditional Chinese medicine that has many medical applications, including wound healing and anti-oxidation. Some traditional Chinese Medicine doctors have found that it has therapeutic effects for external use in the repigmentation of vitiligo and post-inflammatory hypopigmentation. This study was designed to evaluate the effects of madecassoside, a major bioactive component of C. asiatica, on oxidative stress in human melanocytes and its possible mechanism of action...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28531780/vitamin-d-status-and-the-effects-of-oral-vitamin-d-treatment-in-children-with-vitiligo-a-prospective-study
#17
Gülay Karagüzel, Nil P Sakarya, Sevgi Bahadır, Selçuk Yaman, Ayşenur Ökten
BACKGROUND & AIMS: Vitiligo is a pigmentary disorder and autoimmune pathogenesis seems most likely. Decreased vitamin D levels have been related to several autoimmune diseases. Little is known about the association of vitiligo and vitamin D. We aimed to evaluate serum 25-hydroxyvitamin D [25(OH)D] levels in children with vitiligo and to determine the efficacy of oral vitamin D therapy on the repigmentation of vitamin D deficient patients. METHODS: Thirty patients aged 6-17 years with vitiligo and 30 sex- and age-matched apparently healthy controls were included in this prospective study...
October 2016: Clinical Nutrition ESPEN
https://www.readbyqxmd.com/read/28524050/cutaneous-adverse-effects-during-ipilimumab-treatment-for-metastatic-melanoma-a-prospective-study
#18
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Bianca Maria Piraccini, Martina Lambertini, Marco Adriano Chessa, Carlotta Baraldi, Simone Ribero, Ardizzoni Andrea, Barbara Melotti, Annalisa Patrizi
Ipilimumab is an immunomodulatory antibody directed against cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), which is administered to patients with advanced melanoma, with a proven positive effect on overall survival. The cutaneous adverse effects (AEs) of ipilimumab are relatively frequent, although described as usually mild and rarely life threatening. To describe a three-year experience of a single institute in detecting and managing cutaneous AEs. A cohort of patients (n = 41) treated with ipilimumab (3 mg/kg/three weeks) for metastatic melanoma, from 2013 to 2016, was investigated for adverse cutaneous events...
May 19, 2017: European Journal of Dermatology: EJD
https://www.readbyqxmd.com/read/28516068/a-comparison-of-betamethasone-valerate-0-1-cream-twice-daily-plus-oral-simvastatin-versus-betamethasone-valerate-0-1-cream-alone-in-the-treatment-of-vitiligo-patients
#19
Fariba Iraji, Seyed Hossin Banihashemi, Gita Faghihi, Zabihollah Shahmoradi, Nabet Tajmirriahi, Safoura Bokaie Jazi
BACKGROUND: Vitiligo, a common disorder of depigmentation, is often difficult to treat. Corticosteroids are known to be effective, but with modest results. Although simvastatin has been reported to be effective for immunorelated dermatologic disorders including vitiligo, controlled trials are lacking. This study was conducted to compare the efficacy of topical betamethasone valerate 0.1% cream (as a standard method of treatment for vitiligo) versus a combination of betamethasone valerate plus oral simvastatin in the treatment of vitiligo...
2017: Advanced Biomedical Research
https://www.readbyqxmd.com/read/28515990/topical-mycophenolate-mofetil-in-the-treatment-of-vitiligo-a-pilot-study
#20
Farhad Handjani, Shahin Aghaei, Iman Moezzi, Nasrin Saki
BACKGROUND: Vitiligo is a multifactorial disease that is characterized by circumscribed depigmented macules and patches. Autoimmune reactions may play an important role in the pathogenesis of the disease. Mycophenolate mofetil is a drug that inhibits DNA synthesis in lymphocytes and has been used in autoimmune diseases such as immunobullous skin diseases, lupus erythematosus, and autoimmune hepatitis. OBJECTIVES: The objective of this study was to show the efficacy of topical mycophenolate mofetil in the treatment of vitiligo...
April 2017: Dermatology Practical & Conceptual
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