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Liu-mei Hu, Xia Lei, Bo Ma, Yu Zhang, Yan Yan, Ya-lan Wu, Ge-zhi Xu, Wen Ye, Ling Wang, Guo-xu Xu, Guo-tong Xu, Li Wei-Ye
OBJECTIVE: To investigate the possible involvement of erythr opoietin (EPO)/erythropoietin receptor (EPOR) system in neovascularization and vascular regeneration in diabetic retinopathy (DR). METHODS: EPOR positive circulating progenitor cells (CPCs: CD34(+)) and endothelial progenitor cells (EPCs: CD34(+)KDR(+)) were assessed by flow cytometry in type 2 diabetic patients with different stages of DR. The cohort consisted of age- and sex-matched control patients with out diabetes ( n=7),non-proliferative DR (NPDR, n=7),non-proliferative DR (PDR, n=8), and PDR complicated with diabetic nephr opathy (PDR-DN, n=7)...
June 2011: Chinese Medical Sciences Journal, Chung-kuo i Hsüeh K'o Hsüeh Tsa Chih
Amit X Garg, Arthur V Iansavichus, Nancy L Wilczynski, Monika Kastner, Leslie A Baier, Salimah Z Shariff, Faisal Rehman, Matthew Weir, K Ann McKibbon, R Brian Haynes
OBJECTIVE: To develop and test a Medline filter that allows clinicians to search for articles within a clinical discipline, rather than searching the entire Medline database. DESIGN: Diagnostic test assessment framework with development and validation phases. SETTING: Sample of 4657 articles published in 2006 from 40 journals. Reviews Each article was manually reviewed, and 19.8% contained information relevant to the discipline of nephrology...
2009: BMJ: British Medical Journal
Cecile Dessapt, Marc Olivier Baradez, Anthea Hayward, Alessandra Dei Cas, Stephen M Thomas, Giancarlo Viberti, Luigi Gnudi
BACKGROUND: Podocyturia is a marker of diabetic nephr- opathy, a possible determinant of its progression and a powerful risk factor for cardiovascular disease. A reduction in podocyte adhesion to the glomerular basement membrane (GBM) via downregulation of alpha3beta1 integrin expression, the main podocyte anchoring dimer to the GBM, may represent one of the mechanisms of podocyturia in glomerular disease. This study investigated the role of mechanical forces and transforming growth factor beta1 (TGFbeta1) in podocyte adhesion and integrin expression...
September 2009: Nephrology, Dialysis, Transplantation
Richard J Krieg, Johannes D Veldhuis, Barbara A Thornhill, Robert L Chevalier, Gregorio Gil
Chronic renal disease results in growth failure in children. This study sought to determine the influences of early renal failure on body growth, growth hormone (GH) secretion, and GH-dependent hepatic gene expression. Neonatal animals were subjected to five-sixth nephrectomy (Nephr) and monitored during growth. Sham-operated male (Sham) and female (Fem) rats served as controls. Whereas Nephr of adult animals causes renal insufficiency, neonatal nephrectomy leads to frank renal failure. In male Nephr compared with Sham animals, GH half-life and GH pulse frequency increased by 1...
June 2008: Endocrine
Márton Mohás, Nóra Szigeti, Lajos Markó, Gergo A Molnár, Judit Cseh, Boglárka Laczy, Mónika Tamaskó, József Balla, János Kappelmayer, László Wagner, Zoltán Wagner, Botond Csiky, Judit Nagy, István Wittmann
BACKGROUND/AIMS: Proteinuria, hypoproteinaemia, hypoalbuminaemia and oedema are major characteristics of nephrotic syndrome. Aims of this study were to detect serum total LDH activity and its isozymes in nephrotic syndrome. METHODS: In a cross-sectional study, clinical parameters were compared in three cohorts, namely kidney patients with or without nephrotic syndrome and hypoalbuminaemic controls (NEPHR, NON-NEPHR, CONTR, respectively). RESULTS: Serum total LDH activity in the NEPHR group was increased compared with the NON-NEPHR and CONTR groups (p < 0...
2008: Kidney & Blood Pressure Research
Hironobu Shimoyama, Mitsuru Nakajima, Hiroyuki Naka, Yong-Dong Park, Kensuke Hori, Hajime Morikawa, Akira Yoshioka
UNLABELLED: Frasier syndrome (FS) is characterised by male pseudohermaphroditism, slowly progressing nephropathy and frequent development of gonadoblastoma. The Wilms' tumour suppressor gene (WT1 gene) plays an important role in the development of the urogenital system and the gonads. A splice mutation in intron 9 of the WT1 gene was recently described in patients with FS. We analysed the WT1 gene of a Japanese patient with male pseudohermaphroditism, steroid resistant-nephr-opathy and gonadoblastoma by the polymerase chain reaction and direct sequencing and detected a heterozygous point mutation in intron 9...
February 2002: European Journal of Pediatrics
B Iványi, H Fahmy, H Brown, P Szenohradszky, P F Halloran, K Solez
Peritubular capillaries (PCs) with a circumferentially multilayered basement membrane have been suggested as an ultrastructural indicator of chronic renal allograft rejection (CR). The authors validated this lesion as a marker for CR, by analyzing its quantitative features, specificity, and sensitivity in 169 renal biopsy specimens. The mean number of circumferential layers (PCcirc) and the incidences of the grades (mild: 2 to 4, moderate: 5 to 6, severe: 7 or more layers) were investigated in biopsy specimens involving CR (CR(Bx), n = 46), acute rejection (n = 11), normal kidneys (n = 20), psoriatics treated with cyclosporine (n = 13), renal transplants with chronic cyclosporine toxicity (n = 12), native kidney diseases (NKD, n = 56), and transplant nephrectomies attributable to CR (Cr(nephr), n = 11)...
September 2000: Human Pathology
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