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https://www.readbyqxmd.com/read/28326198/could-perinatal-asphyxia-induce-a-synaptopathy-new-highlights-from-an-experimental-model
#1
REVIEW
María Inés Herrera, Matilde Otero-Losada, Lucas Daniel Udovin, Carlos Kusnier, Rodolfo Kölliker-Frers, Wanderley de Souza, Francisco Capani
Birth asphyxia also termed perinatal asphyxia is an obstetric complication that strongly affects brain structure and function. Central nervous system is highly susceptible to oxidative damage caused by perinatal asphyxia while activation and maturity of the proper pathways are relevant to avoiding abnormal neural development. Perinatal asphyxia is associated with high morbimortality in term and preterm neonates. Although several studies have demonstrated a variety of biochemical and molecular pathways involved in perinatal asphyxia physiopathology, little is known about the synaptic alterations induced by perinatal asphyxia...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28326082/neonatal-group-b-streptococcal-disease-in-otherwise-healthy-infants-failure-of-specific-neonatal-immune-responses
#2
Alessandro Borghesi, Mauro Stronati, Jacques Fellay
Only a small proportion of newborn infants exposed to a pathogenic microorganism develop overt infection. Susceptibility to infection in preterm infants and infants with known comorbidities has a likely multifactorial origin and can be often attributed to the concurrence of iatrogenic factors, environmental determinants, underlying pathogenic processes, and probably genetic predisposition. Conversely, infection occurring in otherwise healthy full-term newborn infants is unexplained in most cases. Microbial virulence factors and the unique characteristics of the neonatal immune system only partially account for the interindividual variability in the neonatal immune responses to pathogens...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28325811/a-theoretical-and-practical-approach-to-defining-adequate-oxygenation-in-the-preterm-newborn
#3
REVIEW
Chad C Andersen, Nicolette A Hodyl, Haresh M Kirpalani, Michael J Stark
John Scott Haldane recognized that the administration of supplemental oxygen required titration in the individual. Although he made this observation in adults, it is equally applicable to the preterm newborn. But how, in practice, can the oxygen requirements in the preterm newborn be determined to avoid the consequences of too little and too much oxygen? Unfortunately, the current generation of oxygen saturation trials in preterm newborns guides saturation thresholds rather than individual oxygen requirements...
March 21, 2017: Pediatrics
https://www.readbyqxmd.com/read/28324904/quantifying-neonatal-sucking-performance-promise-of-new-methods
#4
Gilson J Capilouto, Tommy J Cunningham, David R Mullineaux, Eleonora Tamilia, Christos Papadelis, Peter J Giannone
Neonatal feeding has been traditionally understudied so guidelines and evidence-based support for common feeding practices are limited. A major contributing factor to the paucity of evidence-based practice in this area has been the lack of simple-to-use, low-cost tools for monitoring sucking performance. We describe new methods for quantifying neonatal sucking performance that hold significant clinical and research promise. We present early results from an ongoing study investigating neonatal sucking as a marker of risk for adverse neurodevelopmental outcomes...
April 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28324900/infant-guided-co-regulated-feeding-in-the-neonatal-intensive-care-unit-part-ii-interventions-to-promote-neuroprotection-and-safety
#5
Catherine S Shaker
Feeding skills of preterm neonates in a neonatal intensive care unit are in an emergent phase of development and require careful support to minimize stress. The underpinnings that influence and enhance both neuroprotection and safety were discussed in Part I. An infant-guided, co-regulated approach to feeding can protect the vulnerable neonate's neurologic development, support the parent-infant relationship, and prevent feeding problems that may endure. Contingent interventions are used to maintain subsystem stability and enhance self-regulation, development, and coping skills...
April 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28324898/breathing-and-swallowing-the-next-frontier
#6
Roxann Diez Gross, Marybeth Trapani-Hanasewych
The anatomical overlap of the pathways for air passage and nutrition necessitate precise coordination between the two vital functions. Neuroanatomic structures in the brainstem for sucking, breathing, and swallowing are also in close proximity and must swiftly coordinate the processes. In a healthy neonate, the oropharyngeal experience and stimulation of early feeding enables respiratory control during suckling to develop. Despite wide variability among the methods used to investigate breathing and swallowing coordination in infancy, a consistent finding of postswallow exhalation has been reported...
April 2017: Seminars in Speech and Language
https://www.readbyqxmd.com/read/28322431/exploring-societal-solidarity-in-the-context-of-extreme-prematurity
#7
Manya J Hendriks, Hans Ulrich Bucher, Sabine D Klein, Jürg C Streuli, Ruth Baumann-Hölzle, Jean-Claude Fauchère
QUESTION: Extreme prematurity can result in long-term disabilities. Its impact on society is often not taken into account and deemed controversial. Our study examined attitudes of the Swiss population regarding extreme prematurity and people's perspectives regarding the question of solidarity with disabled people. METHODS: We conducted a nationwide representative anonymous telephone survey with 1210 Swiss residents aged 18 years or older. We asked how people estimate their own personal solidarity, the solidarity of their social environment and the solidarity across the country with disabled persons...
March 21, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/28321913/heart-rate-variability-can-be-used-to-evaluate-wellbeing-in-preterm-infants
#8
K Kaar, J Brandner, B Minnich, J Hilberath, C Weisser, M Wald
Preterm infants are exposed to various potentially stressful procedures during intensive care, which have been shown to compromise development. We explored the potential stress caused by echocardiograph and the correlation between the duration of the investigation and the amplitude of the alteration. The usefulness of the Newborn Infant Parasympathetic Evaluation (NIPE) monitor (Mdoloris Medical Systems, Loos, France) for assessing acute distress during daily routines, based on heart rate variability, was also investigated...
March 21, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28320392/prenatal-and-post-natal-cost-of-small-for-gestational-age-infants-a-national-study
#9
Alicia Marzouk, Antoine Filipovic-Pierucci, Olivier Baud, Vassilis Tsatsaris, Anne Ego, Marie-Aline Charles, François Goffinet, Danièle Evain-Brion, Isabelle Durand-Zaleski
BACKGROUND: Small for gestational age (SGA) infants are at increased risk for preterm birth morbidities as well as a range of adverse perinatal outcomes that result in part from associated premature birth. We sought to evaluate the costs of SGA versus appropriate for gestational age (AGA) infants in France from pregnancy through the first year of life and separate the contributions of prematurity from the contribution of foetal growth on costs. METHODS: This is a cross-sectional population-based study using national hospital discharge data from French public and private hospitals...
March 21, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28316097/improved-postnatal-care-is-needed-to-maintain-gains-in-neonatal-survival-after-the-implementation-of-the-helping-babies-breathe-initiative
#10
J Wrammert, A Kc, U Ewald, M Målqvist
AIM: Helping Babies Breathe (HBB) is a neonatal resuscitation protocol proven to reduce intrapartum-related mortality in low-income settings. The aim of this study was to describe the timing and causes of neonatal in-hospital deaths before and after HBB training at a maternity health facility in Nepal. METHODS: A prospective cohort study was conducted at the facility between July 2012 and September 2013. All 137 staff, including medical doctors and midwives, were trained in January 2013...
March 17, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28315973/stem-cell-factor-kit-signal-insufficiency-contributes-to-hypoxia-induced-intestinal-motility-dysfunctions-in-neonatal-mice
#11
Hong Ren, Juan Han, Zhifang Li, Zhiyong Xiong
BACKGROUND: Gastrointestinal (GI) motility disorders represent a group of problems that more constantly encountered in preterm infants. However, whether hypoxia exposure contributes to the GI dysfunctions is still unclear. METHODS: Newborn mice were exposed to hypoxia (10%) from P1 to P7. Intestinal motilities were examined by a strain gauge transducer. The proliferation of ICCs was detected by using immunostaining for BrdU, Ki67, Kit, Ano1, and insulin-like growth factor 1 receptor (IGF-1R+)...
March 18, 2017: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/28315881/new-insights-on-early-patterns-of-respiratory-disease-among-extremely-low-gestational-age-newborns
#12
Stefano Nobile, Paolo Marchionni, Giovanni Vento, Valentina Vendettuoli, Claudio Marabini, Alessandra Lio, Cinzia Ricci, Domenica Mercadante, Mariarosa Colnaghi, Fabio Mosca, Costantino Romagnoli, Virgilio Carnielli
BACKGROUND: The analysis of early patterns of lung disease among preterm infants may help to identify predictors of pulmonary deterioration. OBJECTIVES: To analyze FIO2 requirement in the first 14 days of life among preterm infants and to find predictors of bronchopulmonary dysplasia (BPD). METHODS: Retrospective cohort study. SETTING: 3 Italian level III NICUs. POPULATION: infants born between 240/7 and 276/7 weeks' gestational age (GA) who survived to 14 days...
March 18, 2017: Neonatology
https://www.readbyqxmd.com/read/28315630/risk-factors-for-depressive-symptoms-in-early-postpartum-period-and-after-puerperium-are-they-the-same
#13
(no author information available yet)
OBJECTIVES: Correlation between the occurrence of postnatal depressive symptoms at 5 days and 6 weeks postpartum is well established. The objective of the study was to determine the influence of psychosocial and perinatal factors on the occurrence of postpartum depressive symptoms 2 to 5 days and 6 weeks after delivery. METHODS: 373 women in early postpartum (EPG) and 107 women 6 weeks after delivery (late postpartum group - LPG) completed a questionnaire including questions concerning mothers' characteristics, obstetric and neonatal complications during pregnancy, psychiatric factors and Edinburgh Postnatal Depression Scale (EPDS)...
November 19, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28314860/a-newborn-screening-method-for-cerebrotendinous-xanthomatosis-using-bile-alcohol-glucuronides-and-metabolite-ratios
#14
Frédéric M Vaz, Albert H Bootsma, Willem Kulik, Aad Verrips, Ron A Wevers, Peter C Schielen, Andrea E DeBarber, Hidde H Huidekoper
Cerebrotendinous xanthomatosis (CTX) is a treatable neurodegenerative metabolic disorder of bile acid synthesis where symptoms can be prevented if treatment with chenodeoxycholic acid supplementation is initiated early in life, making CTX an excellent candidate for newborn screening. We developed a new dried blood spot screening assay for this disorder based on different ratios between the accumulating cholestanetetrol glucuronide (tetrol) and specific bile acids/bile acid intermediates, without the need for derivatization...
March 17, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28304327/retinopathy-of-prematurity-in-indonesia-incidence-and-risk-factors
#15
J Edy Siswanto, P Jj Sauer
BACKGROUND: Retinopathy of prematurity (ROP) is a vaso-proliferative disease of the eye, which mainly affects preterm newborn infants with an incompletely vascularized retina. The incidence of ROP has increased in industrialized countries due to the increased survival of extremely low birth weight (ELBW) infants. ROP is also increasing in developing countries like Indonesia, where it is most likely due to the improved survival of ELBW infants. OBJECTIVE: To ascertain the incidence of ROP and possible risk factors associated with the development of ROP in preterm infants in Indonesia...
March 16, 2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/28301846/programming-of-the-hypothalamus-pituitary-adrenal-axis-by-very-preterm-birth
#16
Martijn J J Finken, Bibian van der Voorn, Jonneke J Hollanders, Charlotte A Ruys, Marita de Waard, Johannes B van Goudoever, Joost Rotteveel
BACKGROUND: Many very preterm (i.e., <32 weeks of gestation) newborns fail to mount an adequate adrenocortical response to stress or illness, termed relative adrenal insufficiency. Conversely, later in life these infants show features of increased glucocorticoid bioactivity, such as abdominal adiposity, insulin resistance, raised blood pressure, shorter stature and internalizing problem behavior. SUMMARY: Studies suggested that very preterm newborns have impairments along multiple levels of the hypothalamus-pituitary-adrenal (HPA) axis...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28301833/persistent-environmental-toxicants-in-breast-milk-and-rapid-infant-growth
#17
Rachel Criswell, Virissa Lenters, Siddhartha Mandal, Hein Stigum, Nina Iszatt, Merete Eggesbø
BACKGROUND/AIMS: Many environmental toxicants are passed to infants in utero and through breast milk. Exposure to toxicants during the perinatal period can alter growth patterns, impairing growth or increasing obesity risk. Previous studies have focused on only a few toxicants at a time, which may confound results. We investigated levels of 26 toxicants in breast milk and their associations with rapid infant growth, a risk factor for later obesity. METHODS: We used data from the Norwegian HUMIS study, a multi-center cohort of 2,606 mothers and newborns enrolled between 2002 and 2008...
March 17, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28301484/health-facility-service-availability-and-readiness-for-intrapartum-and-immediate-postpartum-care-in-malawi-a-cross-sectional-survey
#18
Naoko Kozuki, Lolade Oseni, Angella Mtimuni, Reena Sethi, Tambudzai Rashidi, Fannie Kachale, Barbara Rawlins, Shivam Gupta
This analysis seeks to identify strengths and gaps in the existing facility capacity for intrapartum and immediate postpartum fetal and neonatal care, using data collected as a part of Malawi's Helping Babies Breath program evaluation. From August to September 2012, the Maternal and Child Health Integrated Program (MCHIP) conducted a cross-sectional survey in 84 Malawian health facilities to capture current health facility service availability and readiness and health worker capacity and practice pertaining to labor, delivery, and immediate postpartum care...
2017: PloS One
https://www.readbyqxmd.com/read/28293548/age-appropriate-functions-and-dysfunctions-of-the-neonatal-neutrophil
#19
REVIEW
Shelley Melissa Lawrence, Ross Corriden, Victor Nizet
Neonatal and adult neutrophils are distinctly different from one another due to well-defined and documented deficiencies in neonatal cells, including impaired functions, reduced concentrations of microbicidal proteins and enzymes necessary for pathogen destruction, and variances in cell surface receptors. Neutrophil maturation is clearly demonstrated throughout pregnancy from the earliest hematopoietic precursors in the yolk sac to the well-developed myeloid progenitor cells in the bone marrow around the seventh month of gestation...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28292962/staphylococcal-scalded-skin-syndrome-in-an-extremely-preterm-newborn-management-in-a-neonatal-intensive-care-unit
#20
Sonia Valero-Portero, Lorenzo Quesada-Dorigne, Juan José Quesada López, Ángel Bernardo Brea-Lamas, Manuel Cidrás-Pidré
No abstract text is available yet for this article.
March 14, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
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