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https://www.readbyqxmd.com/read/29036213/the-value-of-real-time-continuous-glucose-monitoring-in-premature-infants-of-diabetic-mothers
#1
Hean-Pat Saw, Nai-Wei Yao, Cheng-Di Chiu, Jia-Yuh Chen
To determine the feasibility of using a real-time continuous glucose monitoring system (RTGMS) in intensive care units, our study focus on preterm infants with diabetic mothers owing to their high risk of blood sugar abnormalities. Thirty preterm babies (M = 15 and F = 15; ≤ 36 week gestation age) were studied from within 72 hours of delivery. These babies were admitted to the newborn intensive care and were further categorized into groups based on whether their mothers with or without diabetic mellitus. Blood sugar levels were monitored by both RTGMS and the traditional intermittent arterial line (A-Line) glucose method...
2017: PloS One
https://www.readbyqxmd.com/read/29036193/gestational-age-related-patterns-of-amot-methylation-are-revealed-in-preterm-infant-endothelial-progenitors
#2
Giovanna Vinci, Christophe Buffat, Stéphanie Simoncini, Farid Boubred, Isabelle Ligi, Florent Dumont, Bernard Le Bonniec, Thierry Fournier, Daniel Vaiman, Françoise Dignat-George, Umberto Simeoni
OBJECTIVE: Preterm birth is associated with altered angiogenesis and with increased risk of cardiovascular dysfunction and hypertension at adulthood. We previously demonstrated that in preterm newborns circulating cord blood endothelial progenitor cells (ECFC), responsible for angio/vasculogenesis, are reduced in number and display altered angiogenic properties. Altered angiogenic function was associated with a decreased expression of pro-angiogenic genes, among which the AMOT gene which is a strong positive regulator of angiogenesis...
2017: PloS One
https://www.readbyqxmd.com/read/29035309/serum-magnesium-levels-in-preterm-infants-are-higher-than-adult-levels-a-systematic-literature-review-and-meta-analysis
#3
REVIEW
Jacques Rigo, Catherine Pieltain, Viola Christmann, Francesco Bonsante, Sissel J Moltu, Silvia Iacobelli, Stéphane Marret
Magnesium (Mg) is an essential mineral in the body, impacting the synthesis of biomacromolecules, bone matrix development, energy production, as well as heart, nerve, and muscle function. Although the importance of Mg is evident, reference values for serum Mg (sMg) in pediatric patients (more specifically, in neonates) are not well established. This systematic literature review and meta-analysis (using 47 eligible studies) aims to quantify normal and tolerable ranges of sMg concentrations during the neonatal period and to highlight the factors influencing Mg levels and the importance of regulating sMg levels during pregnancy and birth...
October 16, 2017: Nutrients
https://www.readbyqxmd.com/read/29034376/exploring-the-pregnant-guinea-pig-as-a-model-for-group-b-streptococcus-intrauterine-infection
#4
Maria I Harrell, Kellie Burnside, Christopher Whidbey, Jay Vornhagen, Kristina M Adams Waldorf, Lakshmi Rajagopal
Infection of the amniotic cavity remains a major cause of preterm birth, stillbirth, fetal injury and early onset, fulminant infections in newborns. Currently, there are no effective therapies to prevent in utero infection and consequent co-morbidities. This is in part due to the lack of feasible and appropriate animal models to understand mechanisms that lead to in utero infections. Use of mouse and rat models do not fully recapitulate human pregnancy, while pregnant nonhuman primate models are limited by ethical considerations, technical constraints, and cost...
September 2017: J Infect Dis Med
https://www.readbyqxmd.com/read/29034064/personalized-therapy-against-preeclampsia-by-replenishing-placental-protein-13-pp13-targeted-to-patients-with-impaired-pp13-molecule-or-function
#5
REVIEW
Hamutal Meiri, George Osol, Irene Cetin, Sveinbjörn Gizurarson, Berthold Huppertz
Hypertensive disorders affect about one third of all people aged 20 and above, and are treated with anti-hypertensive drugs. Preeclampsia (PE) is one form of such disorders that only develops during pregnancy. It affects ten million pregnant women globally and additionally causes fetal loss and major newborn disabilities. The syndrome's origin is multifactorial, and anti-hypertensive drugs are ineffective in treating it. Biomarkers are helpful for predict its development. Generic drugs, such as low dose aspirin, were proven effective in preventing preterm PE...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/29031644/a-preliminary-evaluation-of-glial-cell-line-derived-neurotrophic-factor-gdnf-levels-in-cerebrospinal-fluid-across-various-gestational-ages-and-clinical-conditions-of-the-neonate
#6
Rahul Rajkumar, Divya Mamilla, Bhavana Bhaya, Theresa Czech, Esther Kisseih, Arun Saini, Nitin Chouthai
BACKGROUND: This study aims to investigate glial cell derived neurotrophic factor (GDNF) levels in newborns' umbilical cord blood and cerebrospinal fluid across various perinatal growth parameters and clinical conditions. METHODS: Cord blood from 20 newborns and 58 residual CSF samples (stored after completion of clinical testing) were collected. GDNF levels were determined using GDNF ELISA kits from R&D Systems in triplicates with appropriate controls to eliminate background...
October 11, 2017: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29030525/neurodevelopment-at-age-10-years-of-children-born-28-weeks-with-fetal-growth-restriction
#7
Steven J Korzeniewski, Elizabeth N Allred, Robert M Joseph, Tim Heeren, Karl C K Kuban, T Michael O'Shea, Alan Leviton
OBJECTIVES: We sought to evaluate the relationships between fetal growth restriction (FGR) (both severe and less severe) and assessments of cognitive, academic, and adaptive behavior brain function at age 10 years. METHODS: At age 10 years, the Extremely Low Gestational Age Newborns Cohort Study assessed the cognitive function, academic achievement, social-communicative function, psychiatric symptoms, and overall quality of life of 889 children born before 28 weeks' gestation...
October 13, 2017: Pediatrics
https://www.readbyqxmd.com/read/29030411/global-shortage-of-neonatal-and-paediatric-antibiotic-trials-rapid-review
#8
Georgina Thompson, Charlotte I Barker, Laura Folgori, Julia A Bielicki, John S Bradley, Irja Lutsar, Mike Sharland
OBJECTIVES: There have been few clinical trials (CTs) on antibiotics that inform neonatal and paediatric drug labelling. The rate of unlicensed and off-label prescribing in paediatrics remains high. It is unclear whether the current neonatal and paediatric antibiotic research pipeline is adequate to inform optimal drug dosing. Using the ClinicalTrials.gov registry, this review aims to establish the current global status of antibiotic CTs in children up to 18 years of age. METHODS: Studies were identified using key word searches of the ClinicalTrials...
October 13, 2017: BMJ Open
https://www.readbyqxmd.com/read/29028075/safety-of-oral-alpha-lipoic-acid-treatment-in-pregnant-women-a-retrospective-observational-study
#9
E Parente, G Colannino, O Picconi, G Monastra
OBJECTIVE: Alpha-lipoic acid is a natural molecule, which directly or by means of its reduced form, dihydrolipoic acid, exerts antioxidant, anti-inflammatory and immunomodulatory activities, very helpful also in preventing miscarriage and preterm delivery. Used as dietary supplement alpha-lipoic acid was demonstrated to be safe for living organisms even when administered at high doses. However, no study was made so far to verify the safety of its continuous administration on a substantial number of pregnant women...
September 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29024213/the-newborn-rat-gastric-emptying-rate-is-volume-and-not-developmentally-dependent
#10
C H F Ferreira, Y Shifrin, J Pan, J Ivanovska, P J McNamara, J Belik
BACKGROUND: Gastric residuals are a common finding in enterally fed preterm neonates and traditionally thought to reflect immaturity-related delayed gastric emptying. Adult human data suggest that the meal volume regulate the gastric emptying rate, but early in life, this has not been adequately evaluated. The goal of this study was to study the rat postnatal changes in gastric emptying rate and the strain-induced effect on muscle contraction. We hypothesized that the stomach content volume and not developmental factors determines the newborn gastric emptying rate, via the Rho-kinase 2 (ROCK-2) pathway...
October 11, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29022077/no-association-between-periodontitis-and-preterm-low-birth-weight-a-case-control-study
#11
Mariana Fampa Fogacci, Elaine de O C Cardoso, Davi da S Barbirato, Denise Pires de Carvalho, Carmelo Sansone
PURPOSE: This study aimed to investigate the association between periodontitis in pregnant women and adverse pregnancy outcomes by heeding confounding risk factors for preterm low birth weight infants. METHODS: This study was reported according to The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) Statement. A case-control study was conducted. Medical records of all pregnant women attending a prenatal care clinic were screened. Those between 21 and 34 years and gestational age of 28-32 weeks were initially enrolled in the study...
October 11, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29019855/bovine-colostrum-for-preterm-infants-in-the-first-days-of-life-a-randomized-controlled-pilot-trial
#12
Sandra Meinich Juhl, Xuqiang Ye, Ping Zhou, Yanqi Li, Elisabeth Omolabake Iyore, Lixia Zhang, Pingping Jiang, Johannes B van Goudoever, Gorm Greisen, Per Torp Sangild
OBJECTIVES: Mother's own milk (MM) is the best nutrition for newborn preterm infants, but is often limited in supply just after birth. Pasteurized human donor milk (DM), and especially preterm infant formula (IF) are less optimal diets than MM. We hypothesized that it is feasible to use bovine colostrum (BC), the first milk from cows, as a supplement to MM, during the first weeks after preterm birth. METHODS: In an open-label, randomized, controlled pilot safety trial, supplementation of MM with BC was compared with DM supplementation (Danish unit) or IF supplementation (Chinese unit)...
October 10, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29018332/the-beneficial-effects-of-melatonin-administration-following-hypoxia-ischemia-in-preterm-fetal-sheep
#13
Tamara Yawno, Mawin Mahen, Jingang Li, Michael C Fahey, Graham Jenkin, Suzanne L Miller
Melatonin (MLT) is an endogenous hormone that controls circadian cycle. MLT has additional important properties that make it appealing as a neuroprotective agent-it is a potent anti-oxidant, with anti-apoptotic and anti-inflammatory properties. MLT is safe for administration during pregnancy or to the newborn after birth, and can reduce white matter brain injury under conditions of chronic fetal hypoxia. Accordingly, in the current study, we examined whether an intermediate dose of MLT could restore white matter brain development when administered after an acute hypoxic ischemic (HI) insult in preterm fetal sheep...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28981619/cortical-responses-to-alien-odors-in-newborns-an-fnirs-study
#14
Jakob Frie, Marco Bartocci, Hugo Lagercrantz, Pierre Kuhn
Very preterm (VPT) infants are exposed to odors released by healthcare products, triggering the trigeminal and olfactory subsystems. Irritation of the nasal mucosa induces pain in adults. We examined whether preterm and full-term (FT) newborns perceived trigeminal odors at different cortical levels, whether these odors elicit pain, and if oral glucose modulates this pain. We performed 44 recording sessions in newborn (15 VPT infants, 12 VPT infants at term-equivalent age, and 17 FT infants) following exposure to trigeminal/olfactory stimuli from the hospital environment...
August 1, 2017: Cerebral Cortex
https://www.readbyqxmd.com/read/28980302/a-retrospective-study-of-the-prevalence-and-outcomes-of-syphilis-in-pregnancy-in-a-five-year-period
#15
Emily D Ebenezer, Santosh J Benjamin, Rani D Sahni, John Aj Prakash, Hepsy Chelliah, Jiji E Mathews
OBJECTIVE: To determine the prevalence of syphilis in pregnancy and to assess the effect of syphilis on maternal and perinatal outcomes. METHODS: In a retrospective study, data were reviewed for pregnant women who tested positive for syphilis during routine prenatal screening at a center in India between January 2011 and December 2015. Women with both a positive venereal disease research laboratory (VDRL) test and a positive Treponema pallidum hemagglutination assay (TPHA) were considered to have syphilis, and their maternal and fetal outcomes were assessed...
October 5, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/28977331/relationship-between-the-use-of-kangaroo-position-on-preterm-babies-and-mother-child-interaction-upon-discharge
#16
Cynthia Ribeiro do Nascimento Nunes, Luís Gustavo Campos, Aline Moreira Lucena, Janser Moura Pereira, Patrícia Rodrigues da Costa, Flávia Aparecida Felipe de Lima, Vivian Mara Gonçalves de Oliveira Azevedo
OBJECTIVE: To analyze the influence of the Kangaroo Position duration in the initial interactions between mothers and preterm infants. METHODS: This is an exploratory prospective observational study that analyzed the mother-infant interaction during breastfeeding, before hospital discharge. All eligible newborns, with a gestational age of 28-32 weeks and a birth weight of 1,000-1,800 g from June 11 to September 31, 2014 were included. The films of the interaction were evaluated by the "Mother-Baby Interaction Protocol 0-6 months" tool...
April 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28977129/knowledge-about-the-benefits-of-breastfeeding-and-disadvantages-of-the-pacifier-related-to-the-mother-s-practice-with-preterm-infants
#17
Elâine Cristina Vargas Dadalto, Edinete Maria Rosa
OBJECTIVE: To evaluate the knowledge and expectations of mothers of preterm newborn infants admitted in a neonatal intensive care unit about breastfeeding and pacifier use, and to analyze their experience in dealing with the sucking urge in the first months of life. METHODS: Mothers were interviewed during hospitalization of the newborn in the neonatal intensive care unit and when the infant was six months old. All mothers with availability to participate in the study were included...
September 21, 2017: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
https://www.readbyqxmd.com/read/28976322/medical-devices-for-paediatric-apnea-monitoring-and-therapy-past-and-new-trends
#18
Salvatore A Pullano, Ifana Mahbub, Maria Giovanna Bianco, Samira Shamsir, Syed K Islam, Mark S Gaylord, Vichien Lorch, Antonino S Fiorillo
Apnea in the paediatric population is associated with increased morbidity and mortality in a large number of developed as well as developing countries. It is even more prominent in preterm newborn infants and is commonly referred to as apnea of prematurity. Its current diagnosis and therapy involve the use of traditional technologies which often result in discomfort to the infants due to the use of invasive devices attached to their sensitive skin, especially in overnight clinical sleep analysis (for over 12- or 24-hour period)...
September 29, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28975370/mesenchymal-stem-cells-from-preterm-to-term-newborns-undergo-a-significant-switch-from-anaerobic-glycolysis-to-the-oxidative-phosphorylation
#19
Silvia Ravera, Marina Podestà, Federica Sabatini, Chiara Fresia, Marta Columbaro, Silvia Bruno, Ezio Fulcheri, Luca Antonio Ramenghi, Francesco Frassoni
We evaluated the energy metabolism of human mesenchymal stem cells (MSC) isolated from umbilical cord (UC) of preterm (< 37 weeks of gestational age) and term (≥ 37 weeks of gestational age) newborns, using MSC from adult bone marrow as control. A metabolic switch has been observed around the 34th week of gestational age from a prevalently anaerobic glycolysis to the oxidative phosphorylation. This metabolic change is associated with the organization of mitochondria reticulum: preterm MSCs presented a scarcely organized mitochondrial reticulum and low expression of proteins involved in the mitochondrial fission/fusion, compared to term MSCs...
October 3, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28974647/a-quality-improvement-project-to-improve-evidence-based-inhaled-nitric-oxide-use
#20
Colleen A Hughes Driscoll, Natalie L Davis, Megan Miles, Dina El-Metwally
BACKGROUND: Inhaled nitric oxide (INO) reduces extracorporeal membrane oxygenation (ECMO) use in term and near-term neonates with persistent pulmonary hypertension of the newborn; however, its overutilization is increasing. We hypothesized that implementing a shared baseline protocol would safely improve evidence-based INO use in a Level IV neonatal ICU. METHODS: Through several plan-do-study-act cycles, a shared baseline protocol for initiation and weaning of INO was developed and implemented starting in August 2014...
October 3, 2017: Respiratory Care
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