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https://www.readbyqxmd.com/read/28215047/pharyngeal-swallowing-pressures-in-the-base-of-tongue-and-hypopharynx-regions-identified-with-three-dimensional-manometry
#1
Sarah P Rosen, Corinne A Jones, Timothy M McCulloch
OBJECTIVES: This study aims to use three-dimensional (3D) high-resolution manometry to identify circumferential pressure patterns generated within the asymmetrical base-of-tongue and hypopharynx regions of the pharynx during deglutition. STUDY DESIGN: Case series. METHODS: Radial pressures in the regions of interest were evaluated during swallowing events in 12 healthy subjects using 3D high-resolution manometry. RESULTS: Repeated measures analysis of variance revealed asymmetrical pharyngeal clearance pressures in the base-of-tongue and hypopharynx regions during swallowing...
February 19, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28214216/cancer-stem-cell-cytokeratins-and-epithelial-to-mesenchymal-transition-markers-expression-in-oral-squamous-cell-carcinoma-derived-from-ortothopic-xenoimplantation-of-cd44-high-cells
#2
Nathália Paiva de Andrade, Maria Fernanda Setúbal Destro Rodrigues, Camila Oliveira Rodini, Fabio Daumas Nunes
Oral squamous cell carcinoma (OSCC) is the most prevalent neoplasia of oral cavity worldwide and prognosis remains unchanged in decades. Recently, different authors reported that head and neck squamous cell carcinomas have a subpopulation of tumor initiating cells that apparently correspond to cancer stem cells (CSC) and are also responsible for tumor growth and metastasis. The purpose of the present study was to investigate the microscopic and phenotypic characteristics of OSCC tumors induced after orthotopic xenoimplantation of SCC9(WT) cell line and CSC-enriched subpopulation isolated from SCC9 cell line based on high expression of the putative CSC marker CD44...
December 23, 2016: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28212925/reversible-opercular-syndrome-secondary-to-osmotic-demyelination
#3
Shuchit Pandey, Vikram V Holla, Imran Rizvi, Rakesh Shukla
Opercular syndrome (OPS) is characterized by weakness of facial, masticatory, pharyngeal, laryngeal, tongue and brachial muscles on voluntary command with preservation of emotional and reflexive movements. We report a case of 45year old female who developed the features of OPS due to lesions of bilateral frontal opercular region induced by osmotic demyelination secondary to hyperosmolar hyperglycaemia. On follow up at 6 months, she had complete recovery.
February 11, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28210457/non-healing-tongue-ulcer-in-a-rheumatoid-arthritis-patient-medicated-with-leflunomide-an-adverse-drug-event
#4
Eleni-Marina Kalogirou, Nikolaos Katsoulas, Konstantinos I Tosios, Andreas C Lazaris, Alexandra Sklavounou
Leflunomide is a member of the disease modifying anti-rheumatic drugs group used as a treatment modality in active rheumatoid and psoriatic arthritis. "Oral ulcers" are reported in 3-5% of leflunomide medicated rheumatoid arthritis patients with adverse events, but they are not described in detail in the literature. We present a case of an ulcer in the tongue of a rheumatoid arthritis patient managed with leflunomide and contemplate on its pathogenesis. Key words:Leflunomide, oral ulcer, DHODH.
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210455/morphea-en-coup-de-sabre-an-unusual-oral-presentation
#5
Sven Niklander, Constanza Marín, René Martínez, Alfredo Esguep
Morphea, or localized scleroderma, is an inflammatory disease that leads to sclerosis of the skin and underlying tissues due to excessive collagen deposition. Oral involvement is unusual and it may produce white linear fibrotic areas with a scar-like appearance, atrophy of tongue papillae, gingival recession and alveolar bone resorption. We report a case of a 13-year-old girl who consulted for progressive recession on the attached gingiva of her upper left incisors. She also presented a hypopigmented line on the left side skin of her upper lip, which continued through the vermilion and the lip mucosa, including the gingiva of the affected teeth...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210452/ewing-sarcoma-of-the-oral-cavity-a-review
#6
REVIEW
Maria Margaix-Muñoz, José Bagán, Rafael Poveda-Roda
OBJECTIVES: A review is made of the clinical, diagnostic, therapeutic and survival characteristics of Ewing sarcoma (ES) of the oral cavity. MATERIAL AND METHODS: A systematic literature search was carried out, with restrictions referred to time (1960-2014), language (English and Spanish) and type of study (case reports, letters, datasets, reviews). The following MeSH terms and boolean operators were used: Ewing AND Sarcoma AND [tongue, jaw, maxilla, cheek, condyle OR temporomandibular, floor AND mouth, gum OR gingiva, palate OR palatal, lip, uvula, head AND neck]...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28210449/oral-mucosal-lesions-in-a-chilean-elderly-population-a-retrospective-study-with-a-systematic-review-from-thirteen-countries
#7
César Rivera, Daniel Droguett, María-Jesús Arenas-Márquez
BACKGROUND: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. MATERIAL AND METHODS: It was conducted a retrospective study (Talca, Chile)...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28209200/roles-of-preoperative-c-reactive-protein-are-more-relevant-in-buccal-cancer-than-other-subsites
#8
Shiao Fwu Tai, Huei-Tzu Chien, Chi-Kuang Young, Chung-Kang Tsao, Alba de Pablo, Kang-Hsing Fan, Chun-Ta Liao, Hung-Ming Wang, Chung-Jan Kang, Joseph Tung-Chieh Chang, Shiang-Fu Huang
BACKGROUND: C-reactive protein (CRP) is an early marker for inflammation, and a relationship between serum CRP levels and survival in oral cancer has been demonstrated previously. In this study, we investigated the roles of CRP in different oral cancer subsites. METHODS: Three hundred and forty-three oral squamous cell carcinoma patients between June 1999 and March 2015 were retrospectively reviewed. Serum CRP levels were measured preoperatively. RESULTS: The elevation of CRP levels (≥5...
February 16, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28209012/a-case-of-verruciform-xanthoma-arising-in-the-tongue
#9
Yukihiro Hiraishi, Itaru Tojyo, Norifumi Kiga, Koji Tanimoto, Shigeyuki Fujita
Verruciform Xanthoma (VX) is a rare lesion of the oral cavity. Histologically, it is characterized by papillary or verrucous proliferation of squamous epithelium and numerous foam cells. VX arising in the tongue is comparatively rare, as most cases of VX in oral cavity occur in gingiva. A 65-year-old woman was referred to our clinic with a mass on the left side of the tongue. The lesion was yellowish, and its surface was granulated. The patient had neither tenderness nor any symptoms. The lesion was clinically diagnosed to be a benign tumor, and hence, biopsy was performed, according to which it was diagnosed as hyperparakeratosis...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208975/solid-cystic-hypoglossal-nerve-schwannoma-with-fluid-fluid-level-a-rare-case-report
#10
Kulamani Sahoo, Pramod Ramchand Shaha, Rahul Khetawat, Mohd Abbas Ilyas, Gaurav Rajendra Khairnar
Schwannomas (neurinoma, neurilemmoma) are benign slow-growing encapsulated tumours originating from well-differentiated myelin-producing Schwann cells or nerve fiber sheet cells at the glial-Schwann cell junction. Hypoglossal nerve schwannoma mostly develops in the intracranial and extra-cranial segment or in both intracranial and extra-cranial segment forming a dumbbell shape tumour. The peripheral hypoglossal schwannomas are very rare. We present a case of right hypoglossal nerve schwannoma in a 46-year-old female who presented with headache and neck pain since 2 weeks with deviation of tongue to right side since 1 week...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28208439/smallest-chimera-states
#11
Yuri Maistrenko, Serhiy Brezetsky, Patrycja Jaros, Roman Levchenko, Tomasz Kapitaniak
We demonstrate that chimera behavior can be observed in small networks consisting of three identical oscillators, with mutual all-to-all coupling. Three different types of chimeras, characterized by the coexistence of two coherent oscillators and one incoherent oscillator (i.e., rotating with another frequency) have been identified, where the oscillators show periodic (two types) and chaotic (one type) behaviors. Typical bifurcations at the transitions from full synchronization to chimera states and between different types of chimeras have been described...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28208216/msc-derived-ccn2-promotes-the-proliferation-migration-and-invasion-of-human-tongue-squamous-cell-carcinoma-cells
#12
Yu-Ling Wu, Hong-Yu Li, Xiao-Peng Zhao, Jiu-Yang Jiao, Dong-Xiao Tang, Ling-Jian Yan, Quan Wan, Chao-Bin Pan
Recent studies have demonstrated that mesenchymal stem cells (MSCs) exhibit a tropism to tumors and form the tumor stroma. Additionally, we found that MSCs can secrete different types of factors. However, the involvement of MSC-derived factors in human tongue squamous cell carcinoma (TSCC) growth has not been clearly addressed. The CCN family includes multifunctional signaling molecules that affect the initiation and development events of various tumors. In our study, we report that CCN2/connective tissue growth factor (CTGF) was the most highly induced among the CCN family members in MSCs that were co-cultured with TSCC cells...
February 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/28207995/impact-of-continuous-positive-airway-pressure-in-patients-with-obstructive-sleep-apnea-during-drug-induced-sleep-endoscopy
#13
Carlos Torre, Stanley Yung-Chuan Liu, Clete A Kushida, Vladimir Nekhendzy, Leh-Kiong Huon, Robson Capasso
OBJECTIVES: The primary objective of the study was to understand the differential impact of Continuous Positive Airway Pressure (CPAP) on the location, degree, and pattern of airway collapse in Obstructive Sleep Apnea (OSA) patients utilizing Drug Induced Sleep Endoscopy (DISE). STUDY DESIGN: Non-randomized trial. SETTING: University Medical Center. PARTICIPANTS: 15 consecutive OSA patients undergoing DISE. MAIN OUTCOMES AND MEASURES: The patterns of airway collapse were videorecorded at baseline and under differential application of nasal CPAP (nCPAP) at 5,10, and 15 cm H2 O...
February 16, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/28205594/genome-editing-reveals-dmrt1-as-an-essential-male-sex-determining-gene-in-chinese-tongue-sole-cynoglossus-semilaevis
#14
Zhongkai Cui, Yun Liu, Wenwen Wang, Qian Wang, Ning Zhang, Fan Lin, Na Wang, Changwei Shao, Zhongdian Dong, Yangzhen Li, Yingming Yang, Mengzhu Hu, Hailong Li, Fengtao Gao, Zhanfei Wei, Liang Meng, Yang Liu, Min Wei, Ying Zhu, Hua Guo, Christopher H K Cheng, Manfred Schartl, Songlin Chen
Chinese tongue sole is a marine fish with ZW sex determination. Genome sequencing suggested that the Z-linked dmrt1 is a putative male determination gene, but direct genetic evidence is still lacking. Here we show that TALEN of dmrt1 efficiently induced mutations of this gene. The ZZ dmrt1 mutant fish developed ovary-like testis, and the spermatogenesis was disrupted. The female-related genes foxl2 and cyp19a1a were significantly increased in the gonad of the ZZ dmrt1 mutant. Conversely, the male-related genes Sox9a and Amh were significantly decreased...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28204991/intra-oral-administration-of-rebamipide-liquid-prevents-tongue-injuries-induced-by-x-ray-irradiation-in-rats
#15
Takako Nakashima, Naoya Uematsu, Kazushi Sakurai
PURPOSE: Oral mucositis is a common and serious side effect in patients who undergo cytotoxic cancer therapies. The purpose of this study was to investigate the preventive effects of rebamipide on radiation-induced glossitis model in rats. METHODS: Glossitis was induced by a single dose of 15 Gy of X-rays to the snouts of rats (day 0). A novel form of rebamipide liquid comprising its submicronized crystals was administered intra-orally. The preventive effect of rebamipide on tongue injuries was macroscopically evaluated on day 7 following irradiation...
February 15, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28203620/schwannoma-of-the-tongue-a-common-tumour-in-a-rare-location-a-case-report
#16
Ines Abreu, Diogo Roriz, Pedro Rodrigues, Ângela Moreira, Cristina Marques, Filipe Caseiro Alves
Schwannoma is a benign tumour that arises from Schwann cells of the peripheral nerve sheath, and is a common tumour of the head and neck. However, intraoral location is very uncommon (only 1% of all head and neck schwannomas). We report a rare case of lingual schwannoma in a 20-year-old male patient who presented with a small, slow-growing mass over the right lateral border of the tongue with 1 year of evolution and that became recently ulcerated. The patient underwent MRI examination and complete surgical excision...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28203317/synthetic-isoliquiritigenin-inhibits-human-tongue-squamous-carcinoma-cells-through-its-antioxidant-mechanism
#17
Cuilan Hou, Wenguang Li, Zengyou Li, Jing Gao, Zhenjie Chen, Xiqiong Zhao, Yaya Yang, Xiaoyu Zhang, Yong Song
Isoliquiritigenin (ISL), a natural antioxidant, has antitumor activity in different types of cancer cells. However the antitumor effect of ISL on human tongue squamous carcinoma cells (TSCC) is not clear. Here we aimed to investigate the effects of synthetic isoliquiritigenin (S-ISL) on TSCC and elucidate the underlying mechanisms. S-ISL was synthesized and elucidated from its nuclear magnetic resonance spectrum and examined using high performance liquid chromatography. The effects of S-ISL on TSCC cells (Tca8113) were evaluated in relation to cell proliferation, apoptosis and adhesion, migration, and invasion using sulforhodamine B assay, fluorescence microscopy technique, flow cytometry (FCM) analysis, and Boyden chamber assay...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28201986/the-origin-of-chow-chows-in-the-light-of-the-east-asian-breeds
#18
Hechuan Yang, Guodong Wang, Meng Wang, Yaping Ma, Tingting Yin, Ruoxi Fan, Hong Wu, Li Zhong, David M Irwin, Weiwei Zhai, Yaping Zhang
BACKGROUND: East Asian dog breeds are one of the most ancient groups of dogs that radiated after the domestication of the dog and represent the most basal lineages of dog evolution. Among these, the Chow Chow is an ancient breed that embodies very distinct morphological and physiological features, such as sturdy build, dense coat, and blue/purple tongue. RESULTS: Using a Restricted site Associated DNA (RAD) sequencing approach, we sequenced the genomes of nine Chow Chows from China...
February 16, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28198526/tongue-and-lingual-salivary-glands-of-the-canary-sem-and-histochemical-study
#19
Feyza Basak, Sukru Hakan Atalgin, Emine Umran Bozkurt
In this study, morphological characteristics of the canary tongue were examined macroscopically and histologically besides using scanning electron microscopy (SEM). Furthermore, histochemical features of the lingual salivary glands of the canary were also examined. The results suggest that the tongue of the canary has an equilateral quadrangle shape is sloped towards the apex on its dorsal surface; where its sides are bounded by tall epithelial extensions. Additionally, histological examination showed that salivary glands were only present on the body of the tongue and there were no taste buds...
February 15, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/28197773/change-in-tongue-pressure-in-patients-with-head-and-neck-cancer-after-surgical-resection
#20
Yoko Hasegawa, Kazuma Sugahara, Tatsuyuki Fukuoka, Shota Saito, Ayumi Sakuramoto, Nobuhide Horii, Saori Sano, Kana Hasegawa, Yuta Nakao, Tomoki Nanto, Kanenori Kadoi, Kuniyasu Moridera, Kazuma Noguchi, Kazuhisa Domen, Hiromitsu Kishimoto
Tongue pressure is reportedly associated with dysphagia. This study investigated relationships among characteristics of head and neck cancer, tongue pressure and dysphagia screening tests performed in patients with head and neck cancer during the acute phase after surgical resection. Fifty-seven patients (36 men, 21 women; age range 26-95 years) underwent surgical resection and dysphagia screening tests (Repetitive Saliva Swallowing Test, Water Swallowing Test, Modified Water Swallowing Test and Food Test) and pre- and postoperative measurement of tongue pressure at 5 time points (preoperatively, and 1-2 weeks and 1, 2, and 3 months postoperatively)...
February 14, 2017: Odontology
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