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https://www.readbyqxmd.com/read/29925049/anionic-and-cationic-drug-sorption-on-interpolyelectrolyte-complexes
#1
C R M de Lima, D N Gomes, J R de Morais Filho, M R Pereira, J L C Fonseca
Interpolyelectrolyte complexes of chitosan and poly(sodium 4-styrenesulfonate) [NaPSS] were synthesized and obtained in the form of solid particles, with two different sulfonate to aminium molar ratios: 0.7, resulting in particles with positive zeta potential (IPEC+ ), and 1.4, yielding particles with negative zeta potential (IPEC- ). Both particles were characterized as potential drug sorbents using differently charged drugs: sodium cromoglycate (negatively charged), and tetracycline hydrochloride (positively charged)...
June 15, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29924932/design-principles-for-enhancing-sensitivity-in-paper-based-diagnostics-via-large-volume-processing
#2
Eric A Miller, Yara Jabbour Al Maalouf, Hadley D Sikes
In this work, we characterize the impact of large-volume processing upon the analytical sensitivity of flow-through paper-based immunoassays. Larger sample volumes feature greater molar quantities of available analyte, but the assay design principles which would enable the rapid collection of this dilute target are ill-defined. We developed a finite-element model to explore the operat-ing conditions under which processing large sample volumes via pressure-driven convective flow would yield improved binding signal...
June 20, 2018: Analytical Chemistry
https://www.readbyqxmd.com/read/29924768/autologous-dental-pulp-mesenchymal-stem-cells-for-inferior-third-molar-post-extraction-socket-healing-a-split-mouth-randomised-clinical-trial
#3
L Barbier, E Ramos, J Mendiola, O Rodriguez, G Santamaria, J Santamaria, I Arteagoitia
BACKGROUND: Since the discovery of adult mesenchymal stem cells extensive research has been conducted to determine their mechanisms of differentiation and effectiveness in cell therapy and regenerative medicine. MATERIAL AND METHODS: To assess the efficacy of autologous dental pulp mesenchymal stem cells delivered in a collagen matrix for post-extraction socket healing, a single-centre, double-blind, randomised, split-mouth, controlled clinical trial was performed...
June 20, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29924618/the-anticancer-agent-edelfosine-exhibits-a-high-affinity-for-cholesterol-and-disorganizes-liquid-ordered-membrane-structures
#4
Alessio Ausili, Pablo Martinez Valera, Alejandro Torrecillas, Victoria Gómez-Murcia, Ana M deGodos, Senena Corbalan-Garcia, Jose Antonio Teruel, Juan C Gomez-Fernandez
Edelfosine is an anticancer drug with an asymmetric structure because, being a derivative of glycerol, it possesses two hydrophobic substituents of very different lengths. We showed that edelfosine destabilizes liquid ordered membranes formed by either POPC (1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine), SM (sphingomyelin) and cholesterol (1:1:1 molar ratio) or SM and cholesterol (2:1 molar ratio). This was observed by differential scanning calorimetry where a phase transition arises from either of these membrane systems after the addition of edelfosine...
June 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29924439/beyond-simple-ab-diblock-copolymers-application-of-bifunctional-and-trifunctional-raft-agents-to-pisa-in-water
#5
Gaëlle Mellot, Patricia Beaunier, Jean-Michel Guigner, Laurent Bouteiller, Jutta Rieger, François Stoffelbach
The influence of the macromolecular reversible addition-fragmentation chain transfer (macro-RAFT) agent architecture on the morphology of the self-assemblies obtained by aqueous RAFT dispersion polymerization in polymerization-induced self-assembly (PISA) is studied by comparing amphiphilic AB diblock, (AB)2 triblock, and triarm star-shaped (AB)3 copolymers, constituted of N,N-dimethylacrylamide (DMAc = A) and diacetone acrylamide (DAAm = B). Symmetrical triarm (AB)3 copolymers could be synthesized for the first time in a PISA process...
June 20, 2018: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29923776/expression-of-%C3%AE-smooth-muscle-actin-in-the-periodontal-ligament-during-post-emergent-tooth-eruption
#6
Domna Dorotheou, Marie-Luce Bochaton-Piallat, Catherine Giannopoulou, Stavros Kiliaridis
Objective This study was performed to explore the expression of α-smooth muscle actin (α-SMA) in the periodontal ligament (PDL) of young and adult rats during post-emergent tooth eruption in opposed and unopposed teeth at two time points: 3 and 15 days after antagonist loss. Methods Four-week-old (n = 20) and 22-week-old (n = 20) male Wistar rats were used. The right maxillary molar crowns were cut down. PDL samples were isolated from the first mandibular molars at two time points: 3 and 15 days after cut-down of the right maxillary molars...
June 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29923618/antimicrobial-photodynamic-therapy-as-an-adjunct-for-clinical-partial-removal-of-deciduous-carious-tissue-a-minimally-invasive-approach
#7
Pâmela O Ornellas, Leonardo S Antunes, Paula C Motta, Caroline Mendonça, Helvécio Póvoa, Karla Fontes, Natalia Iorio, Lívia A A Antunes
This study aimed to evaluate the use of antimicrobial photodynamic therapy (aPDT) as an adjunct for minimally invasive treatment (partial removal of carious tissue - PRCT) of deciduous carious tissue evaluating its efficacy in reducing microorganisms. For that, a clinical study was design including children with deciduous molars with active deep caries lesions (DCL). PRCT was performed and remaining dentin was treated with 100 μg/mL methylene blue solution (5 min) and than irradiated with a low power laser emitting red light (InGaAIP - indium gallium aluminum phosphide; λ = 660nm; 100mW; 300 J/cm²; 90s; 9J)...
June 20, 2018: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29923406/biorelated-polyelectrolyte-coatings-studied-by-in-situ-atr-ftir-spectroscopy-deposition-concepts-wet-adhesiveness-biomedical-applications
#8
Martin Müller, Birgit Urban, Simona Schwarz
In this conceptual contribution thin functional coatings consisting of either pure polyelectrolytes (PEL) or complexes between oppositely charged PEL at model and applied substrates are outlined. Latter PEL/PEL complexes were deposited by two concepts. In a first well known concept PEL multilayers (PEM) were consecutively deposited according to the Layer-by-Layer (LbL) technique. In a second less known concept PEL complex (PEC) nanoparticles (NP) preformed by mixing polycation (PC) and polyanion (PA) solutions were deposited in one step...
June 20, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29923300/characterization-of-klason-lignin-samples-isolated-from-beech-and-aspen-using-microbore-column-size-exclusion-chromatography
#9
Erik Beňo, Róbert Góra, Milan Hutta
The presented work is focused on the separation and characterization of lignin samples isolated by Klason method from European beech (Fagus sylvatica) broadleaf hardwood and European aspen (Populus tremula) broadleaf softwood by size-exclusion chromatography. The separation was carried out using dimethylformamide as major component of the mobile phase and a 3 mm id microbore column packed with hydroxyethyl methacrylate gel, calibrated with polystyrene standards. The influence of mobile phase composition and sample solvent composition on the chromatographic behavior and molar mass distributions was investigated...
June 19, 2018: Journal of Separation Science
https://www.readbyqxmd.com/read/29923023/biodistribution-of-strontium-and-barium-in-the-developing-and-mature-skeleton-of-rats
#10
Arash Panahifar, L Dean Chapman, Lynn Weber, Nazanin Samadi, David M L Cooper
Bone acts as a reservoir for many trace elements. Understanding the extent and pattern of elemental accumulation in the skeleton is important from diagnostic, therapeutic, and toxicological perspectives. Some elements are simply adsorbed to bone surfaces by electric force and are buried under bone mineral, while others can replace calcium atoms in the hydroxyapatite structure. In this article, we investigated the extent and pattern of skeletal uptake of barium and strontium in two different age groups, growing, and skeletally mature, in healthy rats...
June 19, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29922342/rare-case-of-bilateral-complex-odontoma-associated-with-mandibular-bicuspids
#11
Rangeeth Bollam Nammalwar, Joyson Moses, Sathya Jeeva
Among oral pathologic lesions, odontomas are the most common odontogenic tumor of the jaws and generally asymptomatic. They are mostly diagnosed as a result of routine radiographic investigation. In this report, we describe a very rare occurrence of bilateral complex odontoma in the region of the mandibular second premolar. Conservative surgical procedure was planned, and removal of the odontomas was carried out through the socket after extraction of the deciduous second molars, and the diagnosis was confirmed with a histopathological study...
May 2018: Dental Research Journal
https://www.readbyqxmd.com/read/29922339/evaluation-of-retentive-strength-of-four-luting-cements-with-stainless-steel-crowns-in-primary-molars-an-in-vitro-study
#12
Iman Parisay, Yegane Khazaei
Background: Stainless steel crown (SSC) is the most reliable restoration for primary teeth with extensive caries. Retention is of great importance for a successful restoration and is provided by various factors such as luting cements. The aim of this study was to evaluate the retentive strength of SSC cemented with four different luting cements. Materials and Methods: In this in vitro study, A total of 55 extracted primary first molars were selected. Following crown selection and cementation (one with no cement and four groups cemented with resin, glass ionomer, zinc phosphate, and polycarboxylate), all the specimens were incubated and thermocycled in 5°C-55°C...
May 2018: Dental Research Journal
https://www.readbyqxmd.com/read/29922094/computed-tomography-evaluation-of-root-canal-transportation-using-protaper-race-and-sendoline-rotary-systems-an-ex-vivo-study
#13
Eshaghali Saberi, Bita Aramesh
Background: This ex vivo study aimed to compare transportation of the mesiobuccal root canal of mandibular first molars instrumented with ProTaper, Race and Sendoline rotary systems using cone beam computed tomography (CBCT). Materials and methods: Forty-five mesiobuccal canals of mandibular first molars were randomly divided into three groups of 15. Root canals in each group were instrumented with the ProTaper, Race or Sendoline rotary system according to the manufacturers' instructions...
2018: Clinical, Cosmetic and Investigational Dentistry
https://www.readbyqxmd.com/read/29921973/bandgap-tunable-agins-based-quantum-dots-for-high-contrast-cell-imaging-with-enhanced-photodynamic-and-antifungal-applications
#14
Irshad Ahmad Mir, V S Radhakrishanan, Kamla Rawat, Tulika Prasad, H B Bohidar
Herein, we report a facile microwave-assisted synthesis of cadmium-free water-soluble silver indium sulfide (AgInS2 or AIS) and AgInS@ZnS (or AIS@ZnS) core-shell quantum dots (QDs) using glutathione (GSH) as stabilizer. The core and core-shell nanocrystals exhibit tunable bandgap ranging of 2.3-3.1 and 2.4-3.5 eV, mean particle size of 2.5 and 3.25 nm, quantum yield of 26% and 49%, and fluorescence lifetimes of 326 and 438 ns, respectively. The core-shell QDs exhibit color-tunable emission in the visible region (500 to 600 nm), where the tunability was achieved by varying the molar ratio of Ag:In in the precursors...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29921410/deep-infiltration-for-the-treatment-of-hypomineralized-enamel-lesions-in-a-patient-with-molar-incisor-hypomineralization-a-clinical-case
#15
L Giannetti, A Murri Dello Diago, E Corciolani, E Spinas
This case report presents the technique of deep infiltration for the treatment of hypomineralized enamel lesions in a patient affected by molar incisor hypomineralization (MIH) with the purpose of obtaining an aesthetic improvement in the affected vestibular enamel. Deep infiltration treatment involves a sequence of steps starting with an initial mechanical abrasion of the outside surface of the enamel, followed by a phase of chemical erosion using 15% hydrochloric acid, penetration through the porosity of the enamel by a very fluid resin, and finally the repair of the thin layer of lost enamel using a composite...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29921409/sdr%C3%A2-vs-traditional-composite-in-class-ii-restorations-in-primary-molars
#16
L Giannetti, A Murri Dello Diago, E Spinas
This study aims to compare the clinical characteristics of a new flowable resin-based composite with those of a traditional composite when applied to deciduous molars for class II restorations. Twentyeight children between 6-12 years of age, with paired minimal Class II cavities present on their primary molars, were chosen. The paired cavities were restored with either a microhybrid composite or a new flowable resin-based composite. The composites were assigned to cavities in either the right or left side of the mouth, using random allocation tables...
May 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29921269/deciduous-dental-caries-status-and-associated-risk-factors-among-preschool-children-in-xuhui-district-of-shanghai-china
#17
Hongru Su, Renren Yang, Qinglong Deng, Wenhao Qian, Jinming Yu
BACKGROUND: This study aims to understand the deciduous dental caries status of preschool children in Xuhui District of Shanghai, China and to analyze the associated risk factors. METHODS: In January of 2016, a cross-sectional investigation was conducted to examine the oral health of all the kindergarten children in Xuihui District of Shanghai, China. Meanwhile, a field questionnaire survey was conducted with the children's guardians to ascertain the potential risk factors associated with deciduous dental caries...
June 19, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29921259/comparison-of-the-occlusal-contact-area-of-virtual-models-and-actual-models-a-comparative-in-vitro-study-on-class-i-and-class-ii-malocclusion-models
#18
Hyemin Lee, Jooly Cha, Youn-Sic Chun, Minji Kim
BACKGROUNDS: The occlusal registration of virtual models taken by intraoral scanners sometimes shows patterns which seem much different from the patients' occlusion. Therefore, this study aims to evaluate the accuracy of virtual occlusion by comparing virtual occlusal contact area with actual occlusal contact area using a plaster model in vitro. METHODS: Plaster dental models, 24 sets of Class I models and 20 sets of Class II models, were divided into a Molar, Premolar, and Anterior group...
June 19, 2018: BMC Oral Health
https://www.readbyqxmd.com/read/29921173/sclerostin-neutralizing-antibody-enhances-bone-regeneration-around-oral-implants
#19
Shan Huey Yu, Jie Hao, Tobias Fretwurst, Min Liu, Paul Kostenuik, William V Giannobile, Qiming Jin
BACKGROUND: Dental implants have been an important option for the replacement of missing teeth. A major clinical challenge is how best to accelerate bone regeneration and reduce the healing time for functional restoration after implant placement. Monoclonal antibody against sclerostin (Scl-Ab) has been shown to enhance alveolar bone formation and fracture repair. The aim of this study was to investigate the effects of systemic administration of Scl-Ab on dental implant osseointegration and bone regeneration in an experimental alveolar ridge tooth extraction model...
June 19, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29921017/rna-methylation-in-nuclear-pre-mrna-processing
#20
REVIEW
Helena Covelo-Molares, Marek Bartosovic, Stepanka Vanacova
Eukaryotic RNA can carry more than 100 different types of chemical modifications. Early studies have been focused on modifications of highly abundant RNA, such as ribosomal RNA and transfer RNA, but recent technical advances have made it possible to also study messenger RNA (mRNA). Subsequently, mRNA modifications, namely methylation, have emerged as key players in eukaryotic gene expression regulation. The most abundant and widely studied internal mRNA modification is N6 -methyladenosine (m6 A), but the list of mRNA chemical modifications continues to grow as fast as interest in this field...
June 19, 2018: Wiley Interdisciplinary Reviews. RNA
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