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https://www.readbyqxmd.com/read/29667914/inactivation-of-map3k7-in-foxd1-expressing-cells-results-in-loss-of-mesangial-pdgfr%C3%AE-and-juvenile-kidney-scarring
#1
Michele J Karolak, Justin A Guay, Leif Oxburgh
Transforming growth factor beta (TGFβ) plays a central role in renal scarring, controlling extracellular matrix deposition by interstitial cells and mesangial cells. TGFβ signals through Smad and mitogen activated protein kinase (MAPK) pathways. To understand the role of MAPK in interstitial and mesangial cells, we genetically inactivated TGFβ-activated kinase 1 (Map3k7) using Foxd1+/cre. Embryonic kidney development was unperturbed in mutants, but spontaneous scarring of the kidney ensued during the first postnatal week, with retention of embryonic nephrogenic rests and accumulation of collagen IV in the mesangium...
April 18, 2018: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29667860/educational-needs-in-the-diagnosis-and-management-of-pediatric-functional-constipation-a-us-survey-of-specialist-and-primary-care-clinicians
#2
Justin Barnes, Brandon Coleman, Sharon Hwang, Aleksandra Stolic, Athos Bousvaros, Samuel Nurko, Gregory D Salinas
OBJECTIVES: The goal of this study was to identify opportunities among gastroenterologists and gastroenterology nurse practitioners (NPs)/physician assistants (PAs) for continuing medical education (CME) related to functional constipation. METHODS: An online, case-vignette survey was designed to identify and quantify practice patterns of pediatric gastroenterology clinicians. Case vignettes are a validated method for assessing clinician practice patterns. The survey consisted of three patient cases: a 3-year-old female with a 6-month history of constipation; a 6-year-old male with a 1-year history of constipation refractory to treatment and a sacral dimple with nearby tuft of hair; and a 16-year-old male with a 10-year history of constipation, and a sullen, depressed mood...
April 18, 2018: Postgraduate Medicine
https://www.readbyqxmd.com/read/29667799/shrink-that-frown-botulinum-toxin-therapy-is-lifting-the-face-of-psychiatry
#3
M Axel Wollmer, Insa Neumann, Michelle Magid, Tillmann H Kruger
Treating glabellar frown lines with injections of botulinum toxin is the most frequently applied procedure in aesthetic medicine. In addition to its cosmetic effect, botulinum toxin may also positively modulate mood and affect, which may contribute to its popularity. A series of clinical studies has shown that this modulation can be used in the treatment of major depression. After a single glabellar treatment with botulinum toxin, patients suffering from unipolar depression experienced a quick, strong and sustained improvement in the symptoms of depression...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667796/isotretinoin-the-ups-are-just-as-troubling-as-the-downs
#4
Jay M Truitt, Jason S Reichenberg, Kevin G Sharghi, Shirlene M Sampson, Randall K Roenigk, Michelle Magid
INTRODUCTION: Isotretinoin, previously marketed as Accutane®, is an oral retinoid medication that is used to treat acne and other cutaneous disorders. Although the data is conflicting, previous reports suggest a causal relationship between isotretinoin and depression. When reviewing these previous reports, many patients who were diagnosed as 'depressed' did not undergo a thorough psychiatric evaluation and/or were not diagnosed according to the criteria of the Diagnostic and Statistical Manual of Mental Disorders (DSM)...
April 18, 2018: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/29667739/maternal-depressive-symptoms-during-and-after-pregnancy-and-child-developmental-milestones
#5
Soile Tuovinen, Marius Lahti-Pulkkinen, Polina Girchenko, Jari Lipsanen, Jari Lahti, Kati Heinonen, Rebecca M Reynolds, Esa Hämäläinen, Eero Kajantie, Hannele Laivuori, Anu-Katriina Pesonen, Pia M Villa, Katri Räikkönen
BACKGROUND: Maternal depressive symptoms during and after pregnancy predict poorer child neurodevelopment. The effects of timing, symptom severity, and additive influences remain unclear. METHODS: A total of 2,231 mothers of the Prediction and Prevention of Pre-eclampsia and Intrauterine Growth Restriction (PREDO) study completed the Center for Epidemiological Studies Depression Scale biweekly up to 14 times during pregnancy and twice up to 12 months after pregnancy...
April 18, 2018: Depression and Anxiety
https://www.readbyqxmd.com/read/29667718/trajectories-of-psychopathology-in-extremely-low-birth-weight-survivors-from-early-adolescence-to-adulthood-a-20-year-longitudinal-study
#6
Ryan J Van Lieshout, Mark A Ferro, Louis A Schmidt, Michael H Boyle, Saroj Saigal, Katherine M Morrison, Karen J Mathewson
BACKGROUND: Individuals born extremely preterm are exposed to significant perinatal stresses that are associated with an increased risk of psychopathology. However, a paucity of longitudinal studies has prevented the empirical examination of long-term, dynamic effects of perinatal adversity on mental health. Here, internalizing and externalizing problems from adolescence through adulthood were compared in individuals born at extremely low birth weight (ELBW; <1,000 g) and normal birth weight (NBW; >2,500 g)...
April 18, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29667712/trajectories-of-alcohol-consumption-in-u-s-military-veterans-results-from-the-national-health-and-resilience-in-veterans-study
#7
Brian S Fuehrlein, Lorig K Kachadourian, Elizabeth K DeVylder, Louis A Trevisan, Marc N Potenza, John H Krystal, Steven M Southwick, Robert H Pietrzak
BACKGROUND AND OBJECTIVES: While alcohol use disorder is prevalent in U.S. veterans, little is known about the nature and determinants of predominant trajectories of alcohol consumption in this population. The objective of the current study was to identify predominant trajectories of alcohol consumption over a 4-year period, and baseline determinants of these trajectories in veterans. METHODS: Data were analyzed from the National Health and Resilience in Veteran Study, which surveyed a nationally representative sample of 3,157 veterans (Wave 1)...
April 18, 2018: American Journal on Addictions
https://www.readbyqxmd.com/read/29667694/a-grounded-theory-investigation-into-sophomore-students-recall-of-depression-during-their-freshman-year-in-college-a-pilot-study
#8
Julie M Brandy, Theresa A Kessler, Christina H Grabarek
Using a grounded theory approach, the current descriptive qualitative design was conducted with sophomore students to understand the meaning participants gave their freshman experiences with depression. Twelve participants were recruited using scripted class announcements across campus. After informed consent, interviews began with the question: What was the experience of your freshman year in college? All interviews were completed with the primary investigator and transcribed verbatim. Interviews were analyzed using constant comparative methodology...
April 17, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29667644/emotional-distress-as-a-predictor-of-work-related-musculoskeletal-disorders-in-malaysian-nursing-professionals
#9
Nur Azma Amin, Kia Fatt Quek, Jennifer Anne Oxley, Rahim Noah, Rusli Nordin
BACKGROUND: Emotional distress is becoming a great concern and is more common in both developed and developing countries. It is associated with several disease conditions. OBJECTIVE: To determine the prevalence of self-perceived emotional distress and its relation to work-related musculoskeletal disorders (WRMSDs) in nurses. METHODS: A self-administered questionnaire survey was carried out on 660 female nurses working in public hospitals in the Klang Valley, Malaysia...
April 2018: International Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29667453/impaired-health-related-quality-of-life-and-related-risk-factors-among-u-s-adults-with-asthma
#10
Cynthia A Pate, Hatice S Zahran, Cathy M Bailey
Objective This study assessed Health-related Quality of Life (HRQoL) and related risk factors among adults with asthma in the United States. Using the 2015 Behavioral Risk Factor Surveillance System (BRFSS), we examined the association between four domains of impaired HRQoL and selected explanatory factors.  Methods A BRFSS sample of 39 321 adults with asthma was used in this study. We examined the association between fair/poor health, ≥14 mentally unhealthy days, ≥14 physically unhealthy days, and ≥14 days of activity limitation and selected explanatory variables (sex, race/ethnicity, age, annual household income, healthcare coverage, physical activity, smoking status, Body Mass Index (BMI), having a coexisting disease, and being diagnosed with depression) using multivariable logistic regression models...
April 18, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29667420/spirituality-and-wellbeing-in-later-life-a-multidimensional-approach
#11
Rinat Lifshitz, Galit Nimrod, Yaacov G Bachner
OBJECTIVES: Previous studies pointed at positive associations between spirituality and Subjective Wellbeing (SWB) in later life, but were typically limited to one dimension of spirituality and/or one measure of SWB. Applying Fisher's (2010) multidimensional approach to spirituality and measuring both positive and negative aspects of SWB, this study aims at providing deeper understanding of this association. METHOD: The study was based on an online survey with 306 individuals aged 50 years and over...
April 18, 2018: Aging & Mental Health
https://www.readbyqxmd.com/read/29667320/flotillin-1-interacts-with-the-serotonin-transporter-and-modulates-chronic-corticosterone-response
#12
Sonali N Reisinger, Eryan Kong, Barbara Molz, Thomas Humberg, Spyros Sideromenos, Ana Cicvaric, Thomas Steinkellner, Jae-Won Yang, Maureen Cabatic, Francisco J Monje, Harald H Sitte, Benjamin J Nichols, Daniela D Pollak
Aberrant serotonergic neurotransmission in the brain is considered at the core of the pathophysiological mechanisms involved in neuropsychiatric disorders. Gene by environment interactions contribute to the development of depression and involve modulation of the availability and functional activity of the serotonin transporter (SERT). Using behavioral and in vivo electrophysiological approaches together with biochemical, molecular-biological and molecular imaging tools we establish Flotillin-1 (Flot1) as a novel protein interacting with SERT and demonstrate its involvement in the response to chronic corticosterone (CORT) treatment...
April 18, 2018: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/29667223/mental-health-and-well-being-in-parents-of-excessively-crying-infants-prospective-evaluation-of-a-support-package
#13
C Powell, D Bamber, J Long, R Garratt, J Brown, S Rudge, T Morris, N Bhupendra Jaicim, R Plachcinski, S Dyson, E M Boyle, I St James-Roberts
BACKGROUND: During the first 4 months of age, approximately 20% of infants cry a lot without an apparent reason. Most research has targeted the crying, but the impact of the crying on parents, and subsequent outcomes, need to receive equal attention. This study reports the findings from a prospective evaluation of a package of materials designed to support the well-being and mental health of parents who judge their infant to be crying excessively. The resulting "Surviving Crying" package comprised a website, printed materials, and programme of Cognitive Behaviour Therapy-based support sessions delivered to parents by a qualified practitioner...
April 17, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29667219/depressive-symptoms-are-common-among-rural-malawian-adolescents
#14
T Teivaanmäki, Y B Cheung, K Maleta, M Gandhi, P Ashorn
No abstract text is available yet for this article.
April 17, 2018: Child: Care, Health and Development
https://www.readbyqxmd.com/read/29667199/investigating-the-effect-of-multisensory-stimulation-on-depression-and-anxiety-of-the-elderly-nursing-home-residents-a-randomized-controlled-trial
#15
Iman Moghaddasifar, Malek Fereidooni-Moghadam, Leila Fakharzadeh, Mohamad Hossein Haghighi-Zadeh
PURPOSE: The aim was to determine the effect of multisensory stimulation (MSS) on the depression and anxiety status among nursing home-dwelling elderly people in Ahvaz, Iran. DESIGN AND METHODS: This clinical trial study conducted on 28 old people living in nursing homes in Ahvaz, who were divided into two groups of intervention and control. The interventions included sensory stimulations of touch, sound, and sight for 4 weeks and 3 sessions weekly and 25 min per each session...
April 17, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29667168/cognitive-decline-and-older-driver-crash-risk
#16
Laura A Fraade-Blanar, Beth E Ebel, Eric B Larson, Jeanne M Sears, Hilaire J Thompson, Kwun Chuen G Chan, Paul K Crane
OBJECTIVES: To examine automobile crash risk associated with cognition in older drivers without dementia. DESIGN: Retrospective secondary analysis of longitudinal cohort study. SETTING: Our study used data from the Adult Changes in Thought (ACT) Study merged with Washington State crash reports and licensure records. Data were available from 2002 to 2015. PARTICIPANTS: Group Health enrollees from Washington State aged 65 and older with active driver's licenses (N=2,615)...
April 17, 2018: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29667152/falls-in-mexican-older-adults-aged-60-years-and-older
#17
Luis M Valderrama-Hinds, Soham Al Snih, Nai-Wei Chen, Martin A Rodriguez, Rebeca Wong
BACKGROUND: Falls are a major cause of disability, morbidity, institutionalization, and mortality in older adults. OBJECTIVES: The purpose of the study was to examine the risk factors for falls among Mexican older adults aged 60 years and older. METHODS: This study included 6247 participants and their spouse or partner aged 60 years and older from the Mexican Health and Aging Study, an ongoing longitudinal study (2001-2012) conducted in Mexico...
April 17, 2018: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/29666844/burnout-among-anesthetists-and-intensive-care-physicians
#18
Audrius Mikalauskas, Rimantas Benetis, Edmundas Širvinskas, Judita Andrejaitienė, Šarūnas Kinduris, Andrius Macas, Žilvinas Padaiga
Burnout is a syndrome of depersonalization, emotional exhaustion, and low personal accomplishment. Little is known about burnout in physicians. Our objective was to determine the prevalence of burnout among anesthetists and intensive care physicians, and associations between burnout and personal, as well as professional, characteristics. Methods: In total, 220 anesthetists and intensive care physicians were contacted by email, asking them to participate in the study. For depression screening the PHQ-2 questionnaire, for problem drinking, CAGE items were used...
2018: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29666778/psychiatric-morbidity-perceived-stress-and-ways-of-coping-among-parents-of-children-with-intellectual-disability-in-lahore-pakistan
#19
Muhammad H Sheikh, Sania Ashraf, Nazish Imran, Sadia Hussain, Muhammad W Azeem
Background This study assessed anxiety and depression levels among parents of children with intellectual disability (ID) and analyzed their coping strategies. Methods One hundred parents of children with ID were recruited through child psychiatry outpatient services in a tertiary care setting in Lahore, Pakistan. A structured questionnaire including sociodemographic details, the Agha Khan University Anxiety Depression Scale, the Family Stress and Coping Questionnaire, Brief COPE questionnaire, and Support questionnaire were used for data collection...
February 16, 2018: Curēus
https://www.readbyqxmd.com/read/29666751/an-open-trial-of-individualized-face-to-face-cognitive-behavior-therapy-for-psychological-distress-in-parents-of-children-after-end-of-treatment-for-childhood-cancer-including-a-cognitive-behavioral-conceptualization
#20
Lisa Ljungman, Martin Cernvall, Ata Ghaderi, Gustaf Ljungman, Louise von Essen, Brjánn Ljótsson
Objective: A subgroup of parents of children who have been treated for childhood cancer report high levels of psychological distress. To date there is no empirically supported psychological treatment targeting cancer-related psychological distress in this population. The aim of the current study was to test the feasibility and preliminarily evaluate the effect of individualized face-to-face cognitive behavior therapy (CBT) for parents of children after the end of treatment for childhood cancer...
2018: PeerJ
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