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https://www.readbyqxmd.com/read/28433943/acute-lung-injury-leads-to-depression-like-symptoms-through-upregulation-of-neutrophilic-and-neuronal-nadph-oxidase-signaling-in-a-murine-model
#1
Ahmed Nadeem, Nahid Siddiqui, Naif O Al-Harbi, Sabry M Attia, Shakir D AlSharari, Sheikh F Ahmad
There is an increased prevalence of comorbid major depressive disorders with a number of inflammatory conditions which is thought to result from activation of the immune system. Acute lung injury (ALI) in humans has been also shown to be associated with depression previously. However, no study has explored the mechanism behind ALI-induced depression. NADPH oxidase (NOX-2) derived reactive oxygen species (ROS) are associated with neuropsychiatric disorders including depression. ROS generation via NOX-2 is also shown to be involved in the pathogenesis of ALI...
April 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28433929/pollution-characteristics-and-human-health-risks-of-potentially-eco-toxic-elements-ptes-in-road-dust-from-metropolitan-area-of-hefei-china
#2
Muhammad Ubaid Ali, Guijian Liu, Balal Yousaf, Qumber Abbas, Habib Ullah, Mehr Ahmed Mujtaba Munir, Biao Fu
This study aims to investigate the pollution characteristics of road dust and their associated health risks of potentially toxic elements (PTEs) to humans using array-based risk assessment models described by United States Environmental Protection Agency (USEPA) in a metropolitan area of Hefei, China. Geoaccumulation index (Igeo) was used to describe pollution characteristics of roadside dust in urban, periurban and industrial areas. Results indicate that industrial roadside dust was contaminated with Fe, Ni, Cu, Ti, V, Pb, Ba, Sb, Cr, Sn, Pb, As and Ga showing Igeo value (log2 (x)) between Igeo class 3 to 4...
April 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28433825/a-distributed-framework-for-health-information-exchange-using-smartphone-technologies
#3
Mohamed Abdulnabi, Ahmed Al-Haiqi, Mlm Kiah, A A Zaidan, B B Zaidan, Muzammil Hussein
Nationwide health information exchange (NHIE) continues to be a persistent concern for government agencies, despite the many efforts and the conceived benefits of sharing patient data among healthcare providers. Difficulties in ensuring global connectivity, interoperability, and concerns on security have always hampered the government from successfully deploying NHIE. By looking at NHIE from a fresh perspective and bearing in mind the pervasiveness and power of modern mobile platforms, this paper proposes a new approach to NHIE that builds on the notion of consumer-mediated HIE, albeit without the focus on central health record banks...
April 19, 2017: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/28433764/modeling-of-retention-and-re-entrainment-of-mono-and-poly-disperse-particles-effects-of-hydrodynamics-particle-size-and-interplay-of-different-sized-particles-retention
#4
Enze Ma, Tariq Ouahbi, Huaqing Wang, Nasre-Dine Ahfir, Abdellah Alem, Ahmed Hammadi
In this paper, numerical simulations of experimental data were performed with kinetic rate coefficients to characterize the retention and re-entrainment dynamics under different hydrodynamic conditions for monodisperse and polydisperse latex particles (3, 10, 16μm and the mixture). The results show that drastic increase in fluid velocity provokes hardly any remarkable decrease in retention in the presence of large energy barriers (>2000kT). Systematical increases in deposition and re-entrainment dynamic rates were observed with fluid velocity and/or particle size...
April 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28433757/surgical-volunteerism-or-voluntourism-are-we-doing-more-harm-than-good
#5
EDITORIAL
Faheem Ahmed, Madeline Grade, Carl Malm, Sophia Michelen, Na'eem Ahmed
The significant rise in the number of international health electives undertaken by medical students and doctors in the US, Canada and UK reflects acknowledgement of the inter-connected nature of these challenges to health systems and the drive to help solve them. However, the next generation of international volunteers often operate under a conflicting duality: whilst many of their role models have devoted their lives to global health following a similar volunteering experience, there are pervasive ethical problems associated with short-term global health work that must be identified and addressed to ensure positive outcomes for all parties involved...
April 19, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28433679/part-i-design-synthesis-and-biological-evaluation-of-novel-pyrazole-benzimidazole-conjugates-as-checkpoint-kinase-2-chk2-inhibitors-with-studying-their-activities-alone-and-in-combination-with-genotoxic-drugs
#6
Shadia A Galal, Ahmed S Abdelsamie, Samia A Shouman, Yasmin M Attia, Hamed I Ali, Ashraf Tabll, Reem El-Shenawy, Yasmine S El Abd, Mamdouh M Ali, Abeer E Mahmoud, Abeer H Abdel-Halim, Amal A Fyiad, Adel S Girgis, Hoda I El-Diwani
Activated checkpoint kinase 2 (Chk2) is a tumor suppressor as one of the main enzymes that affect the cell cycle. 2-Biarylbenzimidazoles are potent selective class of Chk2 inhibitors; the structure-based design was applied to synthesize a new series of this class with replacing the lateral aryl group by substituted pyrazoles. Ten pyrazole-benzimidazole conjugates from the best fifty candidates according to docking programs have been subjected to chemical synthesis in this study. The activities of the conjugates 5-14 as checkpoint kinase inhibitors and as antitumor alone and in combination with genotoxic drugs were evaluated...
April 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28433678/montreal-accord-on-patient-reported-outcomes-use-series-paper-4-patient-reported-outcomes-pro-can-inform-clinical-decision-making-in-chronic-care
#7
Clifton O Bingham, Vanessa Noonan, Claudine Auger, Debbie Feldman, Sara Ahmed, Susan J Bartlett
BACKGROUND: Providing patient-centered healthcare requires that patient needs, preferences, and valued outcomes are more fully integrated into all decisions. Patient reported outcome measures (PROs) provide unique information from the patient perspective on overall health, symptoms, burden, and treatment response. OBJECTIVE: We sought to describe applications of PROs in clinical settings and considerations for implementation from the perspectives of PRO researchers, clinicians, administrators, policy makers, and patients attending a multidisciplinary meeting...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433677/montreal-accord-on-patient-reported-outcomes-use-series-paper-9-anonymization-and-ethics-considerations-for-capturing-and-sharing-patient-reported-outcomes-pro
#8
L Arbuckle, E Moher, S J Bartlett, S Ahmed, K El Emam
BACKGROUND: Patient reported outcomes (PRO) are collected with consent for care, however using the data for any other purpose requires consent for that additional purpose, or the anonymization of the data. Collecting explicit consent to use this data for secondary purposes, before the patient completes a PRO, can also bias the responses. OBJECTIVE: We consider the ethical and security issues related to the collection of data at the point of care or in the population, and the aggregation and integration of PRO data with administrative databases to facilitate decision-making and comparative effectiveness research...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433675/montreal-accord-on-patient-reported-outcomes-use-series-paper-8-patient-reported-outcomes-pro-in-electronic-health-records-can-inform-clinical-and-policy-decisions
#9
S Ahmed, P Ware, W Gardner, J Witter, C O Bingham, D Khairy, S J Bartlett
BACKGROUND: Given that the goal of healthcare systems is to improve and maintain the health of the populations they serve, the indicators of performance must include outcomes that are meaningful to patients. The growth of health technologies provides an unprecedented opportunity to integrate the patient voice into clinical care by linking electronic health records (EHR) to patient-reported outcome (PRO) data collection. However, PRO data must be relevant, meaningful, and actionable for those who will have to invest the time and effort to collect it...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433674/montreal-accord-on-patient-reported-outcomes-use-series-paper-6-creating-national-initiatives-to-support-patient-reported-outcomes-pro-development-and-use-the-promis-example
#10
Susan J Bartlett, James Witter, David Cella, Sara Ahmed
BACKGROUND: PRO data are beneficial to a range of stakeholders including patients, clinicians, researchers, national funding and regulatory agencies, health system administrators, and policymakers. OBJECTIVE: Because stakeholders represent diverse groups and needs, it is challenging to reach consensus on how to advance PRO development and harmonize data across settings to enable use for multiple secondary purposes. Collaborative national networks can facilitate the sharing of expertise, resources and necessary infrastructure; create development, use, and reporting standards; optimize formats to efficiently store and transfer data; and disseminate tools and information for widespread uptake...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433673/montreal-accord-on-patient-reported-outcomes-use-series-paper-2-terminology-proposed-to-measure-what-matters-in-health
#11
Nancy E Mayo, Sabrina Figueiredo, Sara Ahmed, Susan Bartlett
BACKGROUND: We outline different health outcomes and describe how multiple perspectives can be harnessed to optimize accuracy of key data collected about patients with chronic conditions. The terms health status, health-related quality of life, and quality of life are often used interchangeably without recognizing that they have different meanings, as are the terms used to refer to the different components of function. While the advantages and limitations of existing frameworks and perspectives are largely understood, greater precision is needed when using health outcome terminology and identifying optimal sources of information...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433672/montreal-accord-on-patient-reported-outcomes-use-series-paper-1-introduction
#12
Susan J Bartlett, Sara Ahmed
BACKGROUND: Patient-centered healthcare, where we design and deliver care to address the needs and preferences of patients, represents an important paradigm shift. Patient reported outcomes (PROs) are critical to capture the patient voice, understand how illness and treatments affect people, and establish how well services and treatments address what matters most to patients. OBJECTIVE: Originally developed for use in research, PROs are now used to monitor individuals and populations, manage care, evaluate services and providers, and inform policy...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28433671/montreal-accord-on-patient-reported-outcomes-use-series-paper-3-patient-reported-outcomes-pro-can-facilitate-shared-decision-making-and-guide-self-management
#13
V K Noonan, A Lyddiatt, P Ware, S B Jaglal, R J Riopelle, C O Bingham, S Figueiredo, R Sawatzky, M Santana, S J Bartlett, S Ahmed
BACKGROUND: There is a shift towards making health care patient-centred whereby patients are part of medical decision-making and take responsibility for managing their health. Patient-reported outcomes (PROs) capture the patient voice and can be used to engage patients in medical decision-making. OBJECTIVE: The objective of this paper is to present important factors from patients', clinicians', researchers', and decision-makers' perspectives that influence successful adoption of PROs in clinical practice...
April 19, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/28432970/insights-into-key-factors-controlling-go-stability-in-natural-surface-waters
#14
Yang Gao, Xuemei Ren, Xiaoli Tan, Tasawar Hayat, Ahmed Alsaedi, Changlun Chen
The effects of pH, cations (Na(+), K(+), Mg(2+), Ca(2+) and Al(3+)), and anions (Cl(-), HCO3(-), HPO4(2-) and SO4(2-)) on graphene oxide (GO) stability were investigated to address the current limitations in the knowledge regarding the stability of GO in natural surface water and its underlying mechanism. The threshold values of cations that destabilize GO were obtained and affected by both pH and anions. By employing elemental mapping and studying the effects of polyacrylic acid (PAA) on GO sedimentation and the re-dispersion of GO aggregates, we find that the GO aggregates induced by Na(+) and K(+) via electric double layer suppression and by Ca(2+) and Al(3+) via strong complxing are difficult to re-disperse completely...
April 11, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28432931/acute-appendicitis-presenting-as-an-abdominal-wall-abscess-a-case-report
#15
Khalid Ahmed, Suhail Hakim, Ahmed M Suliman, Ammar Aleter, Ayman El-Menyar, Sheriff Abdulazeim Mustafa, Ahmad Zarour, Hassan Al-Thani
INTRODUCTION: Amyand hernia (AH) is a rare type of hernia characterized by the presence of appendix vermiformis in the inguinal hernial sac. It is rarely reported in women. PRESENTATION OF CASE: We presented a case of a 60- year old woman who was admitted initially with an abdominal wall abscess and found to have perforated appendix in the right inguinal hernia. The patient underwent standard open appendectomy and the post-operative course was uneventful. DISCUSSION: The initial presentation of our case as an abdominal wall abscess is rare in the contemporary literature...
April 4, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28432916/colorimetric-method-for-the-detection-of-melamine-using-in-situ-formed-silver-nanoparticles-via-tannic-acid
#16
Md Fazle Alam, Amaj Ahmed Laskar, Shahbaz Ahmed, Mohd Azfar Shaida, Hina Younus
Melamine toxicity has recently attracted worldwide attention as it causes renal failure and the death of humans and animals. Therefore, developing a simple, fast and sensitive method for the routine detection of melamine is the need of the hour. Herein, we have developed a selective colorimetric method for the detection of melamine in milk samples based upon in-situ formation of silver nanoparticles (AgNPs) via tannic acid. The AgNPs thus formed were characterized by UV-Visible spectrophotometer, transmission electron microscope (TEM), zetasizer and dynamic light scattering (DLS)...
April 17, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28432605/cardiac-magnetic-resonance-imaging-in-heart-failure-where-the-alphabet-begins
#17
REVIEW
Ahmed Aljizeeri, Abdulbaset Sulaiman, Naji Alhulaimi, Ahmed Alsaileek, Mouaz H Al-Mallah
Cardiac Magnetic Resonance Imaging has become a cornerstone in the evaluation of heart failure. It provides a comprehensive evaluation by answering all the pertinent clinical questions across the full pathological spectrum of heart failure. Nowadays, CMR is considered the gold standard in evaluation of ventricular volumes, wall motion and systolic function. Through its unique ability of tissue characterization, it provides incremental diagnostic and prognostic information and thus has emerged as a comprehensive imaging modality in heart failure...
April 22, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28432433/glypican-3-mrna-expression-level-in-wilms-tumor-correlation-with-histological-type-stage-and-outcome
#18
Md Nahidul Wari, Archana George Vallonthaiel, Aijaz Ahmed, Deepali Saxena, Venkateswaran K Iyer, Sandeep R Mathur, Sandeep Agarwala, Sameer Bakhshi, V Srinivas, P Chattopadhyaya, Arundhati Sharma, S Datta Gupta, Amit Dinda
PURPOSE: To correlate expression of Glypican-3 in Wilms tumor with histopathology, stage, and outcome. METHODS: Glypican-3 mRNA expression by real-time PCR on tumor and normal germline samples from 75 fresh nephrectomies for Wilms tumor with fold change after normalization against GAPDH was compared. Survival analysis for event-free and overall survival (EFS, OS) with 2-year follow-up for Glypican-3 overexpression (>1.5 times) and clinicopathological parameters was performed...
April 21, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28432337/agarose-spot-as-a-comparative-method-for-in-situ-analysis-of-simultaneous-chemotactic-responses-to-multiple-chemokines
#19
Mohaned Ahmed, Haneen A Basheer, Jose M Ayuso, Djevdet Ahmet, Marco Mazzini, Roshan Patel, Steven D Shnyder, Victoria Vinader, Kamyar Afarinkia
We describe a novel protocol to quantitatively and simultaneously compare the chemotactic responses of cells towards different chemokines. In this protocol, droplets of agarose gel containing different chemokines are applied onto the surface of a Petri dish, and then immersed under culture medium in which cells are suspended. As chemokine molecules diffuse away from the spot, a transient chemoattractant gradient is established across the spots. Cells expressing the corresponding cognate chemokine receptors migrate against this gradient by crawling under the agarose spots towards their centre...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431995/robot-assisted-laparoscopic-urachal-excision-in-children
#20
Haris Ahmed, Adam S Howe, Lori L Dyer, Ronnie G Fine, Jordan S Gitlin, Richard N Schlussel, Paul F Zelkovic, Lane S Palmer
OBJECTIVE: To report the first exclusively pediatric series of robot-assisted urachal remnant excisions in children. MATERIALS & METHODS: We reviewed the medical records of all children who underwent robot-assisted excision of urachal remnants from 2010 to 2016. For the procedure, a 3-port approach was performed in all cases. Excision of the urachus was performed, along with partial cystectomy if there was clear or suspected bladder involvement. Outcomes and complications were reviewed...
April 18, 2017: Urology
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