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https://www.readbyqxmd.com/read/29055076/molecular-dissection-of-protein-protein-interactions-between-integrin-%C3%AE-5%C3%AE-1-and-the-helicobacter-pylori-cag-type-iv-secretion-system
#1
Thomas Koelblen, Célia Bergé, Mickaël V Cherrier, Karl Brillet, Luisa Jimenez-Soto, Lionel Ballut, Junichi Takagi, Roland Montserret, Patricia Rousselle, Wolfgang Fischer, Rainer Haas, Rémi Fronzes, Laurent Terradot
The more severe strains of the bacterial human pathogen Helicobacter pylori produce a type IV secretion system (cagT4SS) to inject the oncoprotein CagA into gastric cells. This syringe-like molecular apparatus is prolonged by an external pilus that exploits integrins as receptors to mediate the injection of CagA. The molecular determinants of the interaction of the cagT4SS pilus with the integrin ectodomain are still poorly understood. In this study, we have used surface plasmon resonance (SPR) to generate a comprehensive analysis of the protein-protein interactions between purified CagA, CagL, CagI, CagY repeat domain II (CagY(RRII) ), CagY C-terminal domain (CagY(B)(10) ) and integrin α5β1 ecto- (α5β1(E) ) or headpiece-domain (α5β1(HP) )...
October 21, 2017: FEBS Journal
https://www.readbyqxmd.com/read/29053653/patients-with-advanced-oral-squamous-cell-carcinoma-have-high-levels-of-soluble-e-cadherin-in-the-saliva
#2
S López-Verdín, J-J Soto-Avila, A-L Zamora-Perez, B-P Lazalde-Ramos, M-L Martínez-Fierro, R González-González, N Molina-Frechero, M-A Isiordia-Espinoza, R Bologna-Molina
BACKGROUND: The objective of this study was to assess the potential clinical value of the concentration of soluble salivary E-cadherin (sE-cadherin) compared with the clinical value of the presence of membranous E-cadherin (mE-cadherin) in oral squamous cell carcinoma tumor tissues. MATERIAL AND METHODS: Data regarding patient demographics, clinical stage, saliva and tumor tissue samples were collected. The saliva was analyzed for sE-cadherin protein levels and was compared to the mE-cadherin immunohistochemical expression levels in tumor tissues, which were assessed via the HercepTest® method...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29053148/stress-response-of-a-marine-ammonia-oxidizing-archaeon-informs-physiological-status-of-environmental-populations
#3
Wei Qin, Shady A Amin, Rachel A Lundeen, Katherine R Heal, Willm Martens-Habbena, Serdar Turkarslan, Hidetoshi Urakawa, Kyle C Costa, Erik L Hendrickson, Tony Wang, David Ac Beck, Sonia M Tiquia-Arashiro, Fred Taub, Andrew D Holmes, Neeraja Vajrala, Paul M Berube, Todd M Lowe, James W Moffett, Allan H Devol, Nitin S Baliga, Daniel J Arp, Luis A Sayavedra-Soto, Murray Hackett, E Virginia Armbrust, Anitra E Ingalls, David A Stahl
High representation by ammonia-oxidizing archaea (AOA) in marine systems is consistent with their high affinity for ammonia, efficient carbon fixation, and copper (Cu)-centric respiratory system. However, little is known about their response to nutrient stress. We therefore used global transcriptional and proteomic analyses to characterize the response of a model AOA, Nitrosopumilus maritimus SCM1, to ammonia starvation, Cu limitation and Cu excess. Most predicted protein-coding genes were transcribed in exponentially growing cells, and of ~74% detected in the proteome, ~6% were modified by N-terminal acetylation...
October 20, 2017: ISME Journal
https://www.readbyqxmd.com/read/29050878/stable-symbiotic-nitrogen-fixation-under-water-deficit-field-conditions-by-a-stress-tolerant-alfalfa-microsymbiont-and-its-complete-genome-sequence
#4
Cintia Jozefkowicz, Silvina Brambilla, Romina Frare, Margarita Stritzler, Carlos Piccinetti, Mariana Puente, Carolina Andrea Berini, Pedro Reyes Pérez, Gabriela Soto, Nicolás Ayub
We here characterized the stress-tolerant alfalfa microsymbiont Sinorhizobium meliloti B401. B401-treated plants showed high nitrogen fixation rates under humid and semiarid environments. The production of glycine betaine in isolated bacteroids positively correlated with low precipitation levels, suggesting that this compound acts as a critical osmoprotectant under field conditions. Genome analysis revealed that strain B401 contains alternative pathways for the biosynthesis and uptake of glycine betaine and its precursors...
October 16, 2017: Journal of Biotechnology
https://www.readbyqxmd.com/read/29050595/mixtures-of-ionic-liquids-as-more-efficient-media-for-cellulose-dissolution
#5
Olga Stolarska, Anna Pawlowska-Zygarowicz, Ana Soto, Héctor Rodríguez, Marcin Smiglak
The ability to dissolve cellulose, by using mixtures of ionic liquids, has been studied and compared with results obtained for the corresponding single ionic liquids. The ionic liquid mixtures tested were a 3:7mol/mol mixture of 1-ethyl-3-methylimidazolium chloride ([C2mim]Cl) and 1-ethyl-3-methylimidazolium acetate ([C2mim][OAc]), and the eutectic mixture (i.e., a 5.1:4.9mol/mol ratio) of [C2mim]Cl and 1-butyl-3-methylimidazolium chloride (C4mim]Cl). The amount of dissolved cellulose was investigated at three different temperatures (323, 348, and 373K) for each system...
December 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29048704/hydroxyapatite-decreases-cytotoxicity-of-a-glass-ionomer-cement-by-calcium-fluoride-uptake-in-vitro
#6
Casiano Del Angel-Mosqueda, Rene Hernandez-Delgadillo, Osvelia E Rodríguez-Luis, María T Ramírez-Rodríguez, Silvia Munguía-Moreno, Norma V Zavala-Alonso, Juan M Solís-Soto, María A A Nakagoshi-Cepeda, Rosa I Sánchez-Nájera, Sergio E Nakagoshi-Cepeda, Claudio Cabral-Romero
BACKGROUND: Glass ionomer cements (GICs) are widely used in dentistry because of their remineralizing and cariostatic potential induced by fluoride. In vitro studies have reported cell toxicity triggered by GICs; however, the influence of hydroxyapatite (HAp) must be considered. The aim of this study was to evaluate the effect of HAp in decreasing the cytotoxicity of the GIC 3M Vitrebond in vitro. METHODS: Samples of 3M Vitrebond (powder, liquid and light-cured) were incubated in Dulbecco's modified Eagle's medium-Ham's F12 (DMEM-F12) for 24 hours at 37°C...
October 14, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/29046692/a-patient-with-van-maldergem-syndrome-with-endocrine-abnormalities-hypogonadotropic-hypogonadism-and-breast-aplasia-hypoplasia
#7
Juan Sotos, Katherine Miller, Donald Corsmeier, Naomi Tokar, Benjamin Kelly, Vijay Nadella, Huachun Zhong, Amy Wetzel, Brent Adler, Chack-Yung Yu, Peter White
BACKGROUND: We report a female patient with endocrine abnormalities, hypogonadotropic hypogonadism and amazia (breasts aplasia/hypoplasia but normal nipples and areolas) in a rare syndrome: Van Maldergem syndrome (VMS). CASE PRESENTATION: Our patient was first evaluated at age 4 for intellectual disability, craniofacial features, and auditory malformations. At age 15, she presented with no breast development and other findings consistent with hypogonadotropic hypogonadism...
2017: International Journal of Pediatric Endocrinology
https://www.readbyqxmd.com/read/29046239/increased-peak-wall-stress-but-not-maximum-diameter-is-associated-with-symptomatic-abdominal-aortic-aneurysm
#8
Begoña Soto, Luis Vila, Jaime F Dilmé, Jose R Escudero, Sergi Bellmunt, Mercedes Camacho
OBJECTIVE: Maximum diameter (MD) is the established rupture predictor for abdominal aortic aneurysm (AAA). However, biomechanical markers from finite element analysis (FEA) could be more accurate predictors for these patients. In this study, the association between peak wall stress (PWS) and MD with symptoms of AAA was evaluated. METHODS: Patients diagnosed with infrarenal non-ruptured AAA at the centre between 2009 and 2015 were included. Clinical data, morphological variables (including MD), and the biomechanical variables PWS and diameter normalised PWS (dnPWS) in symptomatic (sAAA) and asymptomatic AAA patients (aAAA) were included...
October 15, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29045823/traditional-uses-phytochemistry-and-pharmacological-properties-of-african-nauclea-species-a-review
#9
REVIEW
Romain Haudecoeur, Marine Peuchmaur, Basile Pérès, Maxime Rome, Germain Sotoing Taïwe, Ahcène Boumendjel, Benjamin Boucherle
ETHNOPHARMACOALOGICAL RELEVANCE: The genus Nauclea in Africa comprises seven species. Among them, N. latifolia, N. diderrichii and N. pobeguinii are widely used by the local population in traditional remedies. Preparation from various parts of plants (e.g. roots, bark, leaves) are indicated by traditional healers for a wide range of diseases including malaria, pain, digestive ailments or metabolic diseases. MATERIALS AND METHODS: A literature search was conducted on African species of the genus Nauclea using scientific databases such as Google Scholar, Pubmed or SciFinder...
October 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29043016/population-structure-of-a-widespread-bat-tadarida-brasiliensis-in-an-island-system
#10
Kelly A Speer, Brandi Jo Petronio, Nancy B Simmons, Rebecca Richey, Kristin Magrini, J Angel Soto-Centeno, David L Reed
Dispersal is a driving factor in the creation and maintenance of biodiversity, yet little is known about the effects of habitat variation and geography on dispersal and population connectivity in most mammalian groups. Bats of the family Molossidae are fast-flying mammals thought to have potentially high dispersal ability, and recent studies have indicated gene flow across hundreds of kilometers in continental North American populations of the Brazilian free-tailed bat, Tadarida brasiliensis. We examined the population genetics, phylogeography, and morphology of this species in Florida and across islands of The Bahamas, which are part of an island archipelago in the West Indies...
October 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29041778/electrolysis-driven-and-pressure-controlled-diffusive-growth-of-successive-bubbles-on-micro-structured-surfaces
#11
Peter van der Linde, Álvaro Moreno-Soto, Pablo Peñas-López, Javier Rodríguez-Rodríguez, Detlef Lohse, Han J G E Gardeniers, Devaraj van der Meer, David Fernandez Rivas
Control over the bubble growth rates forming on the electrodes of water-splitting cells or chemical reactors is critical towards the attainment of higher energy efficiencies within these devices. This study focuses on the diffusion-driven growth dynamics of a succession of H2 bubbles generated at a flat silicon electrode substrate. Controlled nucleation is achieved by means of a single nucleation site consisting of a hydropho- bic micropit etched within a micron-sized pillar. In our experimental configuration of constant-current electrolysis, we identify gas depletion from (i) previous bubbles in the succession, (ii) unwanted bubbles forming on the sidewalls and (iii) the mere presence of the circular cavity where the electrode is being held...
October 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29041496/demonstration-of-an-all-optical-feed-forward-delay-line-buffer-using-the-quadratic-stark-effect-and-two-photon-absorption-in-an-soa
#12
Horacio Soto, Miriam A Tong, Juan C Domínguez, Ramón Muraoka
We have inserted into an unbiased semiconductor optical amplifier (SOA) a powerful control beam, with photon energy slightly smaller than that of the band-gap of its active region, for exciting two-photon absorption and the quadratic Stark effect. For the available SOA, we estimated these phenomena generated a nonlinear absorption coefficient β= -865 cm/GW and induced an appreciable birefringence inside the amplifier waveguide, which significantly modified the polarization-state of a probe beam. Based on these effects, we have experimentally demonstrated the operation of an all-optical buffer, using an 80 Gb/s optical pulse comb, as well as an unbiased SOA, which was therefore, devoid of amplified spontaneous emission and pattern effects...
September 4, 2017: Optics Express
https://www.readbyqxmd.com/read/29041108/unraveling-beam-self-healing
#13
Andrea Aiello, Girish S Agarwal, Martin Paúr, Bohumil Stoklasa, Zdeněk Hradil, Jaroslav Řeháček, Pablo de la Hoz, Gerd Leuchs, Luis L Sánchez-Soto
We show that, contrary to popular belief, diffraction-free beams may not only reconstruct themselves after hitting an opaque obstacle but also, for example, Gaussian beams. We unravel the mathematics and the physics underlying the self-reconstruction mechanism and we provide for a novel definition for the minimum reconstruction distance beyond geometric optics, which is in principle applicable to any optical beam that admits an angular spectrum representation. Moreover, we propose to quantify the self-reconstruction ability of a beam via a newly established degree of self-healing...
August 7, 2017: Optics Express
https://www.readbyqxmd.com/read/29039539/adenoviral%C3%A2-bone-morphogenetic-protein%C3%A2-7-and-or-doxazosin-therapies-promote-the-reversion-of-fibrosis-cirrhosis-in-a-cirrhotic-hamster-model
#14
Daniel Cervantes-Garcia, Adriana Guadalupe Cuellar-Juarez, Gissela Borrego-Soto, Augusto Rojas-Martinez, Liseth Rubi Aldaba-Muruato, Eva Salinas, Javier Ventura-Juarez, Martin Humberto Muñoz-Ortega
Liver fibrosis occurs in the presence of continuous insults, including toxic or biological agents. Novel treatments must focus on ceasing the progression of cellular damage, promoting the regeneration of the parenchyma and inhibition of the fibrotic process. The present study analyzed the effect of bone morphogenetic protein (BMP)‑7 gene therapy with or without co‑treatment with doxazosin in a model of liver cirrhosis in hamsters. The serum alanine aminotransferase, aspartate aminotransferase and albumin levels were analyzed spectrophotometrically...
October 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29039399/mopat-home-electronic-patient-reported-outcomes-filled-out-at-home-evaluated-at-the-hospital
#15
Michael Storck, Susanne Dugas-Breit, Martin Dugas, Iñaki Soto-Rey
No abstract text is available yet for this article.
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29038230/ghrelin-receptor-constitutive-activity-reduces-surface-expression-of-voltage-gated-calcium-channels-in-a-cav%C3%AE-dependent-manner
#16
Emilio R Mustafá, Eduardo J López Soto, Valentina Martínez Damonte, Silvia S Rodríguez, Diane Lipscombe, Jesica Raingo
Voltage gated calcium (CaV) channels couple membrane depolarization to calcium influx, triggering a range of calcium-dependent cellular processes. CaV channels are therefore critical in shaping neuronal activity and function, depending on their individual temporal and spatial properties. Furthermore, many neurotransmitters and drugs that act through G protein coupled receptors (GPCRs), modulate neuronal activity by altering the expression, trafficking, or function of CaV channels. GPCR-dependent mechanisms that down regulate CaV channel expression levels are observed in many neurons but are, by comparison, less studied...
October 16, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/29034862/ultrastructural-and-microbial-analyses-of-cellulose-degradation-in-leaf-cutter-ant-colonies
#17
Rolando Daniel Moreira-Soto, Ethel Sanchez, Cameron R Currie, Adrian A Pinto-Tomás
Leaf-cutter ants (Atta and Acromyrmex) use fresh leaves to cultivate a mutualistic fungus (Leucoagaricus gongylophorus) for food in underground gardens. A new ant queen propagates the cultivar by taking a small fragment of fungus from her parent colony on her nuptial flight and uses it to begin her own colony. Recent research has shown that the ants' fungus gardens are colonized by symbiotic bacteria that perform important functions related to nitrogen fixation and have been implicated in contributing to plant biomass degradation...
October 16, 2017: Microbiology
https://www.readbyqxmd.com/read/29034757/nano-alterations-of-membrane-structure-on-both-%C3%AE-irradiated-and-stored-human-erythrocytes
#18
M A Acosta-Elías, A J Burgara-Estrella, J A Sarabia-Sainz, E Silva-Campa, A Angulo-Molina, K J Santacruz-Gómez, B Castaneda, D Soto-Puebla, A I Ledesma-Osuna, R Melendrez-Amavizca, M Pedroza-Montero
PURPOSE: Storage and ionizing radiation of human red blood cells (RBC) produce alterations on RBC membranes and modify their normal shape and functionality. We investigated early morphological and biochemical changes in RBC due to those stressing agents at the nanoscale level and their impact on blood quality. MATERIALS AND METHODS: Whole blood samples from healthy donors were γ-irradiated with 15, 25, 35 and 50 Gy. Non-irradiated and non-stored RBC were used as control samples...
October 16, 2017: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29032101/mitochondrial-activity-in-t-cells
#19
REVIEW
Gabriela Desdín-Micó, Gonzalo Soto-Heredero, María Mittelbrunn
Mitochondria fulfill important and diverse roles during the different stages of T cell adaptive responses. Here we discuss the role of the mitochondria in T cells from the initial steps of activation at the immune synapse to their participation in memory responses and T cell exhaustion. Mitochondria are relocated to the immune synapse in order to supply local ATP and to aid calcium signaling. During expansion and proliferation, mitochondrial reactive oxygen species drive proliferation. Aerobic glycolysis, glutaminolysis and fatty acid oxidation regulate the program of differentiation into effector or regulatory T cell subsets, and mitochondrial remodeling proteins are required for the long-lasting phenotype of memory cells...
October 12, 2017: Mitochondrion
https://www.readbyqxmd.com/read/29031783/antidiabetic-effect-of-achillea-millefollium-through-multitarget-interactions-%C3%AE-glucosidases-inhibition-insulin-sensitization-and-insulin-secretagogue-activities
#20
Fabiola Chávez-Silva, Litzia Cerón-Romero, Luis Arias-Durán, Gabriel Navarrete-Vázquez, Julio Almanza-Pérez, Rubén Román-Ramos, Guillermo Ramírez-Ávila, Irene Perea-Arango, Rafael Villalobos-Molina, Samuel Estrada-Soto
ETHNOPHARMACOLOGICAL IMPORTANCE: Achillea millefolium L. (Asteraceae) is a perennial herb used in Mexican folk medicine for treatment of several pathologies, including inflammatory and spasmodic gastrointestinal disorders, hepatobiliary complaints, overactive cardiovascular, respiratory ailments and diabetes. AIM OF THE STUDY: To evaluate the potential antidiabetic effect in vivo and to establish the potential mode of action through in vitro approaches of Achillea millefolium...
October 12, 2017: Journal of Ethnopharmacology
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