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Amphotericin nasal rinse

Tianqi Wang, Jinfei Su, Yanjun Feng
Chronic rhinosinusitis (CRS) is believed to be the result of an exaggerated reaction to fungi in the nasal mucosa, and topical amphotericin B (AMB) is a commonly used treatment. The purpose of this study was to perform a meta-analysis of high-quality comparative studies to examine the efficacy of topical AMB for the treatment of CRS. A search was conducted of Medline, Cochrane, EMBASE, and ISI Web of Knowledge until December 31, 2013 using combinations of the search terms chronic rhinosinusitis, human, treatment, antibiotics, nasal irrigation, nebulized, nasal lavage, sinonasal rinses, and antimicrobials...
August 2015: European Archives of Oto-rhino-laryngology
Thiemo Hofmann, Sabine Reinisch, Claus Gerstenberger, Wolfgang Koele, Markus Gugatschka, Gerald Wolf
OBJECTIVES/HYPOTHESIS: Topical antifungal treatment is a subject of discussion in the treatment of chronic rhinosinusitis. The aim of this research was to study the effects of antifungal drugs on ciliary beat frequency (CBF) of human nasal mucosa under in vitro conditions. STUDY DESIGN: Case series of in vitro experiments and in vitro study of cultured ciliated cells of human nasal mucosa. METHODS: Human nasal mucosa was acquired during routine endoscopic sinus surgery...
July 2010: Laryngoscope
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