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https://www.readbyqxmd.com/read/27921303/eosinophils-from-eosinophilic-oesophagitis-patients-have-t-cell-suppressive-capacity-and-express-foxp3
#1
C Lingblom, J Wallander, M Ingelsten, H Bergquist, M Bove, R Saalman, A Welin, C Wennerås
Eosinophilic esophagitis (EoE) is an antigen-driven T cell-mediated chronic inflammatory disease where food and environmental antigens are thought to have a role. Human eosinophils express the immunoregulatory protein galectin-10 and have T cell suppressive capacity similar to regulatory T cells (Tregs ). We hypothesized that one function of eosinophils in EoE might be to regulate the T cell-driven inflammation in the oesophagus. This was tested by evaluating the suppressive capacity of eosinophils isolated from the blood of adult EoE patients in a mixed lymphocyte reaction...
November 5, 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27921169/drying-kinetics-of-deformable-and-cracking-nano-porous-gels
#2
J Thiery, E Keita, S Rodts, D Courtier Murias, T Kodger, A Pegoraro, P Coussot
The desiccation of porous materials encompasses a wide range of technological and industrial processes and is acutely sensitive to the hierarchical structure of the porous materials resulting in complex dynamics which are challenging to unravel. Macroscopic observations of the surface and geometry of model colloidal gels during desiccation under controlled air flow highlight the role of crack formation in drying. The density of cracks and their rate of appearance depend on the initial solid fraction of the gels and their adherence to the substrate...
December 2016: European Physical Journal. E, Soft Matter
https://www.readbyqxmd.com/read/27919850/detection-and-differentiation-of-early-hepatocellular-carcinoma-from-cirrhosis-using-ct-perfusion-in-a-rat-liver-model
#3
Jin-Ping Li, Guang-Long Feng, Da-Qing Li, Hai-Bo Wang, De-Li Zhao, Yong Wan, Hui-Jie Jiang
BACKGROUND: Functional imaging such as CT perfusion can detect morphological and hemodynamic changes in hepatocellular carcinoma (HCC). Pre-carcinoma and early HCC nodules are difficult to differentiate by observing only their hemodynamics changes. The present study aimed to investigate hemodynamic parameters and evaluate their differential diagnostic cut-off between pre-carcinoma and early HCC nodules using CT perfusion and receiver operating characteristic (ROC) curves. METHODS: Male Wistar rats were randomly divided into control (n=20) and experimental (n=70) groups...
December 2016: Hepatobiliary & Pancreatic Diseases International: HBPD INT
https://www.readbyqxmd.com/read/27919541/pesticides-drive-risk-of-micropollutants-in-wastewater-impacted-streams-during-low-flow-conditions
#4
Nicole A Munz, Francis J Burdon, Dick de Zwart, Marion Junghans, Laura Melo, Marta Reyes, Urs Schönenberger, Heinz P Singer, Barbara Spycher, Juliane Hollender, Christian Stamm
Micropollutants enter surface waters through various pathways, of which wastewater treatment plants (WWTPs) are a major source. The large diversity of micropollutants and their many modes of toxic action pose a challenge for assessing environmental risks. In this study, we investigated the potential impact of WWTPs on receiving ecosystems by describing concentration patterns of micropollutants, predicting acute risks for aquatic organisms and validating these results with macroinvertebrate biomonitoring data...
November 3, 2016: Water Research
https://www.readbyqxmd.com/read/27917167/potential-for-sulfate-reduction-in-mangrove-forest-soils-comparison-between-two-dominant-species-of-the-americas
#5
Melike Balk, Joost A Keuskamp, Hendrikus J Laanbroek
Avicennia and Rhizophora are globally occurring mangrove genera with different traits that place them in different parts of the intertidal zone. It is generally accepted that the oxidizing capacity of Avicennia roots is larger than that of Rhizophora roots, which initiates more reduced conditions in the soil below the latter genus. We hypothesize that the more reduced conditions beneath Rhizophora stands lead to more active sulfate-reducing microbial communities compared to Avicennia stands. To test this hypothesis, we measured sulfate reduction traits in soil samples collected from neighboring Avicennia germinans and Rhizophora mangle stands at three different locations in southern Florida...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27916125/high-efficiency-hydrodynamic-chromatography-in-micro-and-sub-micrometer-deep-channels-using-an-on-chip-pressure-generation-unit
#6
Ling Xia, Debashis Dutta
In this article, we report the development of a microchip based hydrodynamic chromatographic device that has an integrated pressure-generation unit to drive the mobile phase during the separation process. The pressure-gradient in this system was realized through introduction of a mismatch in electroosmotic flow rate at the junction of two glass channel segments with different depths as has been previously reported by our research group. A fraction of the resulting pressure-driven flow was then guided into an analysis channel to enable the size-based particle separations...
January 15, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/27915085/monocyte-derived-circulating-microparticles-cd14-cd14-cd11b-and-cd14-cd142-are-related-to-long-term-prognosis-for-cardiovascular-mortality-in-stemi-patients
#7
Gemma Chiva-Blanch, Vibeke Bratseth, Vibeke Ritschel, Geir Ø Andersen, Sigrun Halvorsen, Jan Eritsland, Harald Arnesen, Lina Badimon, Ingebjørg Seljeflot
BACKGROUND: Circulating microparticles (cMPs) have been proposed as novel biomarkers of cardiovascular disease (CVD). We aimed to investigate the prognostic relevance of cMPs for future major adverse cardiovascular events (MACE) in STEMI patients. METHODS: We included 200 STEMI patients treated with percutaneous coronary intervention (PCI). One hundred patients with a primary composite end point (recurrent nonfatal acute MI, rehospitalization for heart failure, unscheduled PCI or death because of CV causes) were case-matched for sex, age, and CVD risk factors to 100 patients without a primary endpoint at the end of study follow-up (4...
November 27, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27914491/impact-of-lesion-characteristics-on-the-prediction-of-optimal-poststent-fractional-flow-reserve
#8
Hirohiko Ando, Hiroaki Takashima, Akihiro Suzuki, Shinichiro Sakurai, Soichiro Kumagai, Akiyoshi Kurita, Katsuhisa Waseda, Tetsuya Amano
BACKGROUND: Poststent fractional flow reserve (FFR) is a useful indicator of optimal percutaneous coronary intervention, and higher poststent FFR is associated with favorable long-term clinical outcome. However, little is known about the factors influencing poststent FFR. The purpose of this study was to determine the impact of lesion characteristics on poststent FFR. METHODS: For patients who had scheduled stent implantation for stable angina, FFR measurements at maximum hyperemia were performed before and after coronary stent implantation...
December 2016: American Heart Journal
https://www.readbyqxmd.com/read/27913605/non-alcoholic-fatty-liver-disease-is-associated-with-early-left-ventricular-dysfunction-in-childhood-acute-lymphoblastic-leukaemia-survivors
#9
Maurizio Delvecchio, Paola Muggeo, Mariantonietta Monteduro, Giuseppe Lassandro, Chiara Novielli, Federica Valente, Emanuela Salinaro, Annapaola Zito, Marco Matteo Ciccone, Vito Leonardo Miniello, Nicola Santoro, Paola Giordano, Maria Felicia Faienza
BACKGROUND: Childhood acute lymphoblastic leukaemia (ALL) survivors have an increased risk of metabolic and cardiovascular disease. We aimed to assess the presence of non-alcoholic fatty liver disease (NAFLD) in childhood ALL and if it is associated with early cardiovascular dysfunction. METHODS: In total, 53 childhood ALL survivors and 34 controls underwent auxological evaluation, biochemical assay, liver, heart and vascular ultrasound study. RESULTS: NAFLD was more frequent in ALL patients than in controls (39...
February 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/27913032/intervention-studies-of-inhaled-corticosteroids-combined-with-long-acting-theophylline-or-long-acting-%C3%AE-2-agonists-in-patients-with-moderate-to-severe-asthma-a-randomized-controlled-study
#10
Yan Wang, Ping Chen, Anna Dai, Shengyun Shang, Lingfei Kong
PURPOSE: To evaluate and contrast the therapeutic effect and safety of fluticasone aerosol combined with theophylline tablets in patients with moderate to severe asthma, compared with salmeterol/fluticasone propionate aerosol. METHODS: After a screening period, patients meeting the inclusion criteria were randomly assigned to the experiment group (fluticasone aerosol combined with theophylline tablets) or the control group (salmeterol/fluticasone aerosol combined with placebo tablets) for 12 weeks of treatment...
November 29, 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27912872/anti-allergic-potential-of-typhonium-blumei-inhibition-of-degranulation-via-suppression-of-pi3k-plc%C3%AE-2-phosphorylation-and-calcium-influx
#11
Michal Korinek, Kuan-Ming Chen, Yu-Han Jiang, Mohamed El-Shazly, Joel Stocker, Chon-Kit Chou, Tsong-Long Hwang, Yang-Chang Wu, Bing-Hung Chen, Fang-Rong Chang
BACKGROUND: Typhonium blumei Nicolson & Sivadasan (Araceae) is a traditional Chinese medicinal herb possessing detumescent, detoxifying, and anti-inflammatory activities. It is used in Taiwan as a folk medicine to treat cancer and inflammatory diseases. Typhonium blumei is usually not distinguished from Typhonium roxburghii Schott and they are commonly used interchangeably. PURPOSE: To evaluate and compare the anti-allergic and anti-inflammatory properties of T...
December 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27912739/comparing-the-adverse-clinical-outcomes-associated-with-fraction-flow-reserve-guided-versus-angiography-guided-percutaneous-coronary-intervention-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#12
Pravesh Kumar Bundhun, Chandra Mouli Yanamala, Feng Huang
BACKGROUND: Recently published randomized controlled trials have shown different results compared to the Fraction Flow Reserve Versus Angiography for Multi-vessel Evaluation (FAME) study. Therefore, this current analysis aimed to compare the adverse clinical outcomes associated with Fraction Flow Reserve (FFR)-guided versus standard angiography-guided Percutaneous Coronary Intervention (PCI) using a large number of randomized patients. METHODS: PubMed/Medline, EMBASE and the Cochrane library were searched for studies comparing FFR-guided with angiography-guided PCI...
December 3, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27910991/structural-fingerprints-of-yielding-mechanisms-in-attractive-colloidal-gels
#13
Arman Boromand, Safa Jamali, João M Maia
Core-Modified Dissipative Particle Dynamics (CM-DPD) with a modified depletion potential and full hydrodynamics description is used to study non-equilibrium properties of colloidal gels with short range attraction potentials at an intermediate volume fraction (ϕ = 0.2) under start-up shear deformation. Full structural and rheological analysis using the stress fabric tensor complemented by bond number and bond distribution evolution under flow reveals that similarly to dilute colloidal gels, flow-induced anisotropy and strain-induced stretching of bonds are present during the first yielding transition...
December 2, 2016: Soft Matter
https://www.readbyqxmd.com/read/27910785/characterization-of-cross-flow-ultrafiltration-fractions-from-maitake-medicinal-mushroom-grifoia-frondosa-agaricomycetes-reveals-distinct-cytotoxicity-in-tumor-cells
#14
Miriam Sari, Reinhard Hambitzer, Jan I Lelley, Katharina Toepler, Nicole Teusch, Anna Nickisch-Hartfiel
β-glucans from Basidiomycetes like Grifola frondosa (the maitake mushroom) are well known for their health benefits. Polysaccharide preparations from medicinal mushrooms such as G. frondosa have been successfully tested in a vast number of studies. Many mushroom extracts have been developed and today are merchandized for use medicinally and commercially. Studies could show that, in particular, chemical structural features such as the molecular size of β-glucans significantly influence their bioactivity. Thus it is highly important to explore the composition and structural properties of β-glucans extracted from medicinal mushrooms and their effects on human tumor cell viability...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27910522/design-and-characterization-of-a-linear-hencken-type-burner
#15
M F Campbell, G A Bohlin, P E Schrader, R P Bambha, C J Kliewer, K O Johansson, H A Michelsen
We have designed and constructed a Hencken-type burner that produces a 38-mm-long linear laminar partially premixed co-flow diffusion flame. This burner was designed to produce a linear flame for studies of soot chemistry, combining the benefit of the conventional Hencken burner's laminar flames with the advantage of the slot burner's geometry for optical measurements requiring a long interaction distance. It is suitable for measurements using optical imaging diagnostics, line-of-sight optical techniques, or off-axis optical-scattering methods requiring either a long or short path length through the flame...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27908646/left-ventricular-function-in-healthy-term-neonates-during-the-transitional-period
#16
Amish Jain, Afif F El-Khuffash, Bart C W Kuipers, Adel Mohamed, Kim A Connelly, Patrick J McNamara, Robert P Jankov, Luc Mertens
OBJECTIVES: To evaluate whether incorporating conventional, tissue Doppler imaging and speckle tracking echocardiography are reliable and can characterize changes in left ventricular (LV) function properly in healthy neonates in the early transitional newborn period. STUDY DESIGN: A prospective observational study was conducted in 50 healthy term neonates with a mean ± SD gestational age and birth weight of 39.3 ± 1.2 weeks and 3.5 ± 0.44 kg, respectively...
November 28, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27908505/diagnostic-advantage-of-stress-computed-tomography-myocardial-perfusion-over-single-photon-emission-computed-tomography-for-the-assessment-of-myocardial-ischemia
#17
Yasushi Ueki, Atsushi Izawa, Daisuke Kashiwagi, Shigeki Nishiyama, Shinichi Aso, Chihiro Suzuki, Shumpei Sakurai, Kazuhiro Oguchi, Yoshikazu Yazaki, Uichi Ikeda, Koichiro Kuwahara
BACKGROUND: This study compared adenosine stress computed tomography myocardial perfusion (CTP) with single-photon emission computed tomography (SPECT) in the diagnosis of functionally significant coronary artery stenosis using fractional flow reserve (FFR) as reference standard. METHODS: We included a total of 93 coronary arteries from 31 patients in whom at least one vessel with ≥50% stenosis was detected with computed tomography coronary angiography. All patients underwent both SPECT and adenosine stress CTP, followed by invasive coronary angiography (ICA) and FFR...
November 28, 2016: Journal of Cardiology
https://www.readbyqxmd.com/read/27906702/diagnostic-accuracy-of-intraluminal-blood-speckle-intensity-on-intravascular-ultrasound-for-physiological-assessment-of-coronary-artery-stenosis
#18
Yuichi Saito, Hideki Kitahara, Takashi Nakayama, Yoshihide Fujimoto, Yoshio Kobayashi
OBJECTIVES: The difference in intraluminal intensity of blood speckle (IBS) on integrated backscatter intravascular ultrasound (IVUS) across the coronary stenosis was reportedly correlated with fractional flow reserve (FFR) in the left descending coronary artery. The aim of this study was to investigate the novel physiological assessment using IVUS in all coronary arteries. PATIENTS AND METHODS: Fifty-four patients with 57 coronary lesions underwent both FFR and IVUS...
November 30, 2016: Coronary Artery Disease
https://www.readbyqxmd.com/read/27904937/separation-of-cyclic-lipopeptide-puwainaphycins-from-cyanobacteria-by-countercurrent-chromatography-combined-with-polymeric-resins-and-hplc
#19
José Cheel, Petra Urajová, Jan Hájek, Pavel Hrouzek, Marek Kuzma, Elodie Bouju, Karine Faure, Jiří Kopecký
Puwainaphycins are a recently described group of β-amino fatty acid cyclic lipopeptides of cyanobacterial origin that possess interesting biological activities. Therefore, the development of an efficient method for their isolation from natural sources is necessary. Following the consecutive adsorption of the crude extract on Amberlite XAD-16 and XAD-7 resins, countercurrent chromatography (CCC) was applied to separate seven puwainaphycin variants from a soil cyanobacterium (Cylindrospermum alatosporum CCALA 988)...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27903180/results-of-volume-staged-fractionated-gamma-knife-radiosurgery-for-large-complex-arteriovenous-malformations-obliteration-rates-and-clinical-outcomes-of-an-evolving-treatment-paradigm
#20
Alberto Franzin, Pietro Panni, Giorgio Spatola, Antonella Del Vecchio, Alberto L Gallotti, Carmen R Gigliotti, Andrea Cavalli, Carmine A Donofrio, Pietro Mortini
OBJECTIVE There are few reported series regarding volume-staged Gamma Knife radiosurgery (GKRS) for the treatment of large, complex, cerebral arteriovenous malformations (AVMs). The object of this study was to report the results of using volume-staged Gamma Knife radiosurgery for patients affected by large and complex AVMs. METHODS Data from 20 patients with large AVMs were prospectively included in the authors' AVM database between 2004 and 2012. A staging strategy was used when treating lesion volumes larger than 10 cm(3)...
December 2016: Journal of Neurosurgery
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