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fractional flow

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https://www.readbyqxmd.com/read/28445787/adipose-derived-stem-cells-were-impaired-in-restricting-cd4-t-cell-proliferation-and-polarization-in-type-2-diabetic-apoe-mouse
#1
Ming-Hao Liu, Ya Li, Lu Han, Yao-Yuan Zhang, Di Wang, Zhi-Hao Wang, Hui-Min Zhou, Ming Song, Yi-Hui Li, Meng-Xiong Tang, Wei Zhang, Ming Zhong
BACKGROUND: Atherosclerosis (AS) is the most common and serious complication of type 2 diabetes mellitus (T2DM) and is accelerated via chronic systemic inflammation rather than hyperglycemia. Adipose tissue is the major source of systemic inflammation in abnormal metabolic state. Pro-inflammatory CD4(+)T cells play pivotal role in promoting adipose inflammation. Adipose-derived stem cells (ADSCs) for fat regeneration have potent ability of immunosuppression and restricting CD4(+)T cells as well...
April 23, 2017: Molecular Immunology
https://www.readbyqxmd.com/read/28445281/relationship-between-the-abnormal-diastolic-vortex-structure-and-impaired-left-ventricle-filling-in-patients-with-hyperthyroidism
#2
Bin-Yu Zhou, Ming-Xing Xie, Jing Wang, Xin-Fang Wang, Qing Lv, Man-Wei Liu, Shuang-Shuang Kong, Ping-Yu Zhang, Jin-Feng Liu
Intraventricular hydrodynamics plays an important role in evaluating cardiac function. Relationship between diastolic vortex and left ventricular (LV) filling is still rarely elucidated. The aim of this study was to evaluate the evolution of vortex during diastole in hyperthyroidism (HT) and explore the alteration of hydromechanics characteristics with sensitive indexes.Forty-three patients diagnosed with HT were classified into 2 groups according to whether myocardial damage existed: simple hyperthyroid group (HT1, n = 21) and thyrotoxic cardiomyopathy (HT2, n = 22)...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28445076/image-based-phenotypic-screening-with-human-primary-t-cells-using-one-dimensional-imaging-cytometry-with-self-tuning-statistical-gating-algorithms
#3
Steve S Wang, Daniel J Ehrlich
The parallel microfluidic cytometer (PMC) is an imaging flow cytometer that operates on statistical analysis of low-pixel-count, one-dimensional (1D) line scans. It is highly efficient in data collection and operates on suspension cells. In this article, we present a supervised automated pipeline for the PMC that minimizes operator intervention by incorporating multivariate logistic regression for data scoring. We test the self-tuning statistical algorithms in a human primary T-cell activation assay in flow using nuclear factor of activated T cells (NFAT) translocation as a readout and readily achieve an average Z' of 0...
April 1, 2017: SLAS Discovery
https://www.readbyqxmd.com/read/28444915/hydroquinone-induces-tk6-cell-growth-arrest-and-apoptosis-through-parp-1-p53-regulatory-pathway
#4
Hao Luo, Hairong Liang, Jiajia Chen, Yongchun Xu, Yuting Chen, Longmei Xu, Lin Yun, Jiaxian Liu, Hui Yang, Linhua Liu, Jianming Peng, Zhidong Liu, Lin Tang, Wen Chen, Huanwen Tang
Hydroquinone (HQ), one of the most important metabolites derived from benzene, induces cell cycle arrest and apoptosis. Poly(ADP-ribose) polymerase-1 (PARP-1) participates in various biological processes, including DNA repair and cell cycle regulation. To explore whether PARP-1 regulatory pathway mediated HQ-induced cell cycle arrest and apoptosis, we assessed the effect of PARP-1 suppression on induction of apoptosis analyzed by FACSCalibur flow cytometer in PARP-1 deficientTK6 cells (TK6-shPARP-1). We observed an increase in the fraction of cells in G1 phase by 7...
April 26, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28444153/computed-tomography-derived-fractional-flow-reserve-testing-in-stable-patients-with-typical-angina-pectoris-influence-on-downstream-rate-of-invasive-coronary-angiography
#5
Jesper Møller Jensen, Hans Erik Bøtker, Ole Norling Mathiassen, Erik Lerkevang Grove, Kristian Altern Øvrehus, Kamilla Bech Pedersen, Christian Juhl Terkelsen, Evald Høj Christiansen, Michael Maeng, Jonathon Leipsic, Anne Kaltoft, Lars Jakobsen, Jacob Thorsted Sørensen, Troels Thim, Steen Dalby Kristensen, Lars Romer Krusell, Bjarne Linde Nørgaard
Aims: To assess the use of downstream coronary angiography (ICA) and short-term safety of frontline coronary CT angiography (CTA) with selective CT-derived fractional flow reserve (FFRCT) testing in stable patients with typical angina pectoris. Methods and results: Between 1 January 2016 and 30 June 2016 all patients (N = 774) referred to non-emergent ICA or coronary CTA at Aarhus University Hospital on a suspicion of CAD had frontline CTA performed. Downstream testing and treatment within 3 months and adverse events ≥90 days were registered...
April 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28444128/low-dose-ionizing-radiation-induces-therapeutic-neovascularization-in-a-pre-clinical-model-of-hindlimb-ischemia
#6
Augusto Ministro, Paula de Oliveira, Raquel J Nunes, André Dos Santos Rocha, Adriana Correia, Tânia Carvalho, José Rino, Pedro Faísca, Jorg D Becker, J Goyri-O'Neill, Filomena Pina, Esmeralda Poli, Bruno Silva-Santos, Fausto Pinto, Marc Mareel, Karine Serre, Susana Constantino Rosa Santos
We have previously shown that low-dose ionizing radiation (LDIR) induces angiogenesis but there is no evidence that they induce neovascularization in the setting of peripheral arterial disease. Here, we investigated the use of LDIR as an innovative and non-invasive strategy to stimulate therapeutic neovascularization using a model of experimentally induced hindlimb ischemia (HLI). Methods and results: After surgical induction of unilateral HLI, both hindlimbs of female C57BL/6 mice were sham-irradiated or irradiated with four daily fractions of 0...
April 19, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28444062/prognostic-value-of-coronary-flow-reserve-obtained-on-dobutamine-stress-echocardiography-and-its-correlation-with-target-heart-rate
#7
José Sebastião de Abreu, Eduardo Arrais Rocha, Isadora Sucupira Machado, Isabelle O Parahyba, Thais Brito Rocha, Fernando José Villar Nogueira Paes, Tereza Cristina Pinheiro Diogenes, Marília Esther Benevides de Abreu, Ana Gardenia Liberato Ponte Farias, Marcia Maria Carneiro, José Nogueira Paes
Background: Normal coronary flow velocity reserve (CFVR) (≥ 2) obtained in the left anterior descending coronary artery (LAD) from transthoracic echocardiography is associated with a good prognosis, but there is no study correlating CFVR with submaximal target heart rate (HR). Objective: To evaluate the prognostic value of CFVR obtained in the LAD of patients with preserved (>50%) left ventricular ejection fraction (LVEF) who completed a dobutamine stress echocardiography (DSE), considering target HR...
April 20, 2017: Arquivos Brasileiros de Cardiologia
https://www.readbyqxmd.com/read/28442659/diagnostic-accuracy-of-endocardial-to-epicardial-myocardial-blood-flow-ratio-for-the-detection-of-significant-coronary-artery-disease-with-dynamic-myocardial-perfusion-dual-source-computed-tomography
#8
Yoshitaka Goto, Kakuya Kitagawa, Mio Uno, Shiro Nakamori, Tatsuro Ito, Naoki Nagasawa, Kaoru Dohi, Hajime Sakuma
BACKGROUND: Previous dynamic stress computed tomography perfusion (CTP) studies used absolute myocardial blood flow (MBF in mL/100 g/min) as a threshold to discriminate flow-limiting coronary artery disease (CAD), but absolute MBF can be vary because of multiple factors. The aim of this study was to compare the diagnostic performance of absolute MBF and the transmural perfusion ratio (TPR) for the detection of flow-limiting CAD, and to clarify the influence of CT delayed enhancement (CTDE) on the diagnostic performance of CTP...
April 25, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28442440/impact-of-dose-and-surface-features-on-plasmatic-and-liver-concentrations-of-biodegradable-polymeric-nanocapsules
#9
Líliam Teixeira Oliveira, Mônica Auxiliadora de Paula, Bruno Mendes Roatt, Giani Martins Garcia, Luan Silvestro Bianchini Silva, Alexandre Barbosa Reis, Carina Silva de Paula, José Mário Carneiro Vilela, Margareth Spangler Andrade, Gwenaelle Pound-Lana, Vanessa Carla Furtado Mosqueira
The effect of polymeric nanocapsule dose on plasmatic and liver concentrations 20min after intravenous administration in mice was evaluated. Nanocapsules were prepared with different polymers, namely, poly(D,L-lactide) (PLA), polyethylene glycol-block-poly(D,L-lactide) (PLA-PEG), and PLA with chitosan (PLA-Cs) and compared with a nanoemulsion. These formulations were labelled with a phthalocyanine dye for fluorescent detection. The nanostructures had narrow size distributions upon separation by asymmetric flow field flow fractionation with static and dynamic light scattering detection, with average hydrodynamic diameters in the 130-300nm range, negative zeta potentials, except PLA-Cs nanocapsules, which had a positive zeta potential...
April 22, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28442070/comparing-airways-clearance-techniques-in-chronic-obstructive-pulmonary-disease-and-bronchiectasis-positive-expiratory-pressure-or-temporary-positive-expiratory-pressure-a-retrospective-study
#10
Francesco D'Abrosca, Barbara Garabelli, Gloria Savio, Agnese Barison, Lorenzo Appendini, Luis V F Oliveira, Paola Baiardi, Bruno Balbi
BACKGROUND: Airway clearance techniques include positive expiratory pressure, commonly used in our clinical practice, and a recently introduced temporary positive expiratory pressure device called UNIKO(®). It is unclear which one provides the best benefit to patients. OBJECTIVES: The aim of this observational 4-year study was to retrospectively compare the efficacy of and specific indications for temporary positive expiratory pressure compared to positive expiratory pressure in a standard rehabilitation program...
January 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28438974/b-anthracis-edema-toxin-increases-fractional-free-water-and-sodium-reabsorption-in-an-isolated-perfused-rat-kidney-model
#11
Dharmvir S Jaswal, Xizhong Cui, Parizad Torabi-Parizi, Lernik Ohanjanian, Hannish Sampath-Kumar, Yvonne Fitz, Yan Li, Wanying Xu, Peter Q Eichacker
Introduction:B. anthracis edema toxin (ET) consists of protective antigen (PA), necessary for host cell toxin uptake, and edema factor (EF), the toxic moiety which increases host cell cAMP. Since vasopressin stimulates renal water and sodium reabsorption via increased tubular cell cAMP, we hypothesized ET would also. To test this hypothesis, we employed an isolated perfused rat kidney model. Methods and Results: Kidneys were isolated and perfused with modified Krebs-Henseleit. Perfusate and urine samples were obtained at baseline and every 10 minutes over 150 minutes following addition to the perfusate of challenges with or without treatments...
April 24, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28437577/high-gene-flow-despite-opposite-chirality-in-hybrid-zones-between-enantiomorphic-door-snails
#12
Eva L Koch, Marco T Neiber, Frank Walther, Bernhard Hausdorf
We studied differentiation and gene flow patterns between enantiomorphic door-snail species in two hybrid zones in the Bucegi Mountains (Romania) to investigate the effects of intrinsic barriers (complications in copulation) and extrinsic selection by environmental factors. A mitochondrial gene tree confirmed the historical separation of the examined populations into the dextral Alopia livida and the sinistral Alopia straminicollis in accordance with the morphological classification, but also indicated gene flow between the species...
April 24, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28436268/collateral-circulation-alters-downstream-hemodynamic-stress-caused-by-intracranial-atherosclerotic-stenosis
#13
Xin Liu, David Dornbos, Yuehua Pu, Xinyi Leng, Ligang Song, Baixue Jia, Yuesong Pan, David Wang, Zhongrong Miao, Yilong Wang, Liping Liu, Yongjun Wang
OBJECTIVES: Fractional flow reserve (FFR) accurately predicts the degree of stenosis and is now widely used to identify clinically significant severe coronary artery lesions. In the current study, we utilized a similar indicator, fractional flow (FF), to determine the hemodynamic impact of symptomatic intracranial atherosclerotic stenosis (ICAS) and to assess the correlation of FF with the severity of stenosis and collateral circulation. METHODS: Patients with symptomatic ICAS (70-99% stenosis) confirmed on digital subtraction angiography (DSA) were consecutively recruited...
April 23, 2017: Neurological Research
https://www.readbyqxmd.com/read/28435954/electrostatically-stabilized-hybrids-of-carbon-and-maghemite-nanoparticles-electrochemical-study-and-application
#14
D Baratella, M Magro, P Jakubec, E Bonaiuto, J de Almeida Roger, E Gerotto, G Zoppellaro, J Tucek, K C Safarova, R Zbořil, A Cecconello, I Willner, S Santagata, P Sambo, F Vianello
Binary hybrids have been investigated for the past few decades due to the emerging properties of nanoparticle composites. Electrostatically stabilized core-shell nanostructures composed of surface active magnetic nanoparticles (SAMNs) and differently charged carbon nanomaterials display specific electrochemical properties. In this work, a set of binary hybrids that include a new class of magnetic nanoparticles is presented and the electrochemical features of the hybrids are reported. Gallic acid derived carbon dots (GA-CDs), PEG derived graphene dots (PEG-GDs), and quaternized carbon dots (Q-CDs) characterized by different charged groups were used for the preparation of different complexes with SAMNs...
April 24, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28434162/isolation-of-astrocytes-displaying-myofibroblast-properties-and-present-in-multiple-sclerosis-lesions
#15
Nicolas Vedrenne, Vincent Sarrazy, Laurence Richard, Nelly Bordeau, Serge Battu, Fabrice Billet, Alexis Desmoulière
A wide heterogeneity of lesions can affect the central nervous system (CNS). In all situations where neurons are damaged, including multiple sclerosis (MS), a common reactive astrocytosis is present. Sedimentation field-flow fractionation (SdFFF) was used to sort astrocyte subpopulations. After SdFFF elution, cells, prepared from rat newborn cortex, were cultured and analyzed by immunocytofluorescence for glial fibrillary acidic protein (GFAP) and α-smooth muscle (SM) actin (a specific marker for myofibroblasts) expression...
April 22, 2017: Neurochemical Research
https://www.readbyqxmd.com/read/28433765/geochemical-processes-controlling-the-distribution-and-concentration-of-metals-in-soils-from-a-patagonian-argentina-salt-marsh-affected-by-mining-residues
#16
Yanina L Idaszkin, María Del Pilar Alvarez, Eleonora Carol
Heavy metal pollution that affects salt marshes is a major environmental concern due to its toxic nature, persistence, and potential risk to organisms and to human health. Mining waste deposits originated four decades ago, by the metallurgical extraction of heavy metals, are found near to the San Antonio salt marsh in Patagonia. The aim of the work was to determine the geochemical processes that control the distribution and concentration of Cu, Fe, Pb and Zn in the soils of this Patagonian salt marsh. A survey of the mining waste deposits was carried out where three dumps were identified...
April 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28433590/low-dose-out-of-field-radiotherapy-part-3-qualitative-and-quantitative-impact-of-scattered-out-of-field-radiation-on-mda-mb-231-cell-lines
#17
K Zaleska, W M Suchorska, A Kowalik, M Kruszyna, W Jackowiak, A Skrobala, M Skorska, J Malicki
PURPOSE: Patients who undergo external beam radiotherapy are at risk of developing second tumours due to scattered radiation outside the path of the primary beam. The aim of this study was to experimentally determine the in vitro radiobiological effects of scattered radiation in cells located outside the primary photon beam and to compare this to the effects that occur in cells inside the primary beam. The comparison was performed by assessing cell viability, DNA damage, and apoptosis...
April 19, 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/28432630/the-influence-of-restoration-measures-on-phosphorus-internal-loading-from-the-sediments-of-a-hypereutrophic-lake
#18
Katarzyna Kowalczewska-Madura, Renata Dondajewska, Ryszard Gołdyn, Stanisław Podsiadłowski
Uzarzewskie Lake was a hypereutrophic, dimictic lake characterized by low water transparency, high chlorophyll-a concentration and intense phytoplankton blooms; thus, restoration treatment was started. A chemical treatment, based on phosphorus inactivation with small doses of iron sulphate, was undertaken in 2006-2007. Nitrate-rich groundwater flowing from seepage springs was directed into the lake hypolimnion to increase redox potential since 2008. Phosphorus internal loading was reduced by more than 80% as a result of restoration treatment...
April 22, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28432341/detection-of-red-blood-cell-surface-antigens-by-probe-triggered-cell-collision-and-flow-retardation-in-an-autonomous-microfluidic-system
#19
Éva Sautner, Krisztián Papp, Eszter Holczer, Eszter L Tóth, Rita Ungai-Salánki, Bálint Szabó, Péter Fürjes, József Prechl
Microfluidic devices exploit combined physical, chemical and biological phenomena that could be unique in the sub-millimeter dimensions. The current goal of development of Point-of-Care (POC) medical devices is to extract the biomedical information from the blood. We examined the characteristics of blood flow in autonomous microfluidic devices with the aim to realize sensitive detection of interactions between particulate elements of the blood and the appropriately modified surfaces of the system. As a model experiment we demonstrated the fast analysis of the AB0 blood group system...
April 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28431738/aortic-valve-replacement-in-low-flow-low-gradient-aortic-stenosis-left-ventricular-ejection-fraction-matters
#20
EDITORIAL
Victor Dayan, Philippe Pibarot
No abstract text is available yet for this article.
April 2, 2017: Journal of Thoracic and Cardiovascular Surgery
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