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https://www.readbyqxmd.com/read/28813561/comparison-of-coronary-ct-angiography-spect-pet-and-hybrid-imaging-for-diagnosis-of-ischemic-heart-disease-determined-by-fractional-flow-reserve
#1
Ibrahim Danad, Pieter G Raijmakers, Roel S Driessen, Jonathon Leipsic, Rekha Raju, Chris Naoum, Juhani Knuuti, Maija Mäki, Richard S Underwood, James K Min, Kimberly Elmore, Wynand J Stuijfzand, Niels van Royen, Igor I Tulevski, Aernout G Somsen, Marc C Huisman, Arthur A van Lingen, Martijn W Heymans, Peter M van de Ven, Cornelis van Kuijk, Adriaan A Lammertsma, Albert C van Rossum, Paul Knaapen
Importance: At present, the choice of noninvasive testing for a diagnosis of significant coronary artery disease (CAD) is ambiguous, but nuclear myocardial perfusion imaging with single-photon emission tomography (SPECT) or positron emission tomography (PET) and coronary computed tomography angiography (CCTA) is predominantly used for this purpose. However, to date, prospective head-to-head studies are lacking regarding the diagnostic accuracy of these imaging modalities. Furthermore, the combination of anatomical and functional assessments configuring a hybrid approach may yield improved accuracy...
August 16, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28812203/assessment-of-methodologies-to-calculate-intraventricular-pressure-differences-in-computational-models-and-patients
#2
Francisco J Londono-Hoyos, Abigail Swillens, Joris Van Cauwenberge, Brett Meyers, Maheswara Reddy Koppula, Pavlos Vlachos, Julio A Chirinos, Patrick Segers
Intraventricular pressure differences (IVPDs) govern left ventricular (LV) efficient filling and are a significant determinant of LV diastolic function. Our primary aim is to assess the performance of available methods (color M-mode (CMM) and 1D/2D MRI-based methods) to determine IVPDs from intracardiac flow measurements. Performance of three methods to calculate IVPDs was first investigated via an LV computational fluid dynamics (CFD) model. CFD velocity data were derived along a modifiable scan line, mimicking ultrasound/MRI acquisition of 1D (IVPDCMM/IVPD1D MRI) and 2D (IVPD2D MRI) velocity-based IVPD information...
August 16, 2017: Medical & Biological Engineering & Computing
https://www.readbyqxmd.com/read/28811971/preclinical-immunopet-ct-imaging-using-zr-89-labeled-anti-pd-l1-monoclonal-antibody-for-assessing-radiation-induced-pd-l1-upregulation-in-head-and-neck-cancer-and-melanoma
#3
Masahiro Kikuchi, David A Clump, Raghvendra M Srivastava, Lingyi Sun, Dexing Zeng, Julio A Diaz-Perez, Carolyn J Anderson, W Barry Edwards, Robert L Ferris
Radiation therapy (RT) can induce upregulation of programmed death ligand 1 (PD-L1) on tumor cells or myeloid cells, which may affect response to PD-1-based immunotherapy. PD-L1 upregulation during RT is a dynamic process that has been difficult to monitor during treatment. The aim of this study was to evaluate the RT-induced PD-L1 upregulation in the tumor and its microenvironment using immunoPET/CT imaging of two syngeneic murine tumor models (HPV+ head and neck squamous cell carcinoma (HNSCC) or B16F10 melanoma)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811373/friction-law-and-hysteresis-in-granular-materials
#4
E DeGiuli, M Wyart
The macroscopic friction of particulate materials often weakens as the flow rate is increased, leading to potentially disastrous intermittent phenomena including earthquakes and landslides. We theoretically and numerically study this phenomenon in simple granular materials. We show that velocity weakening, corresponding to a nonmonotonic behavior in the friction law, [Formula: see text], is present even if the dynamic and static microscopic friction coefficients are identical, but disappears for softer particles...
August 15, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28810795/the-effects-of-slit-like-confinement-on-flow-induced-polymer-deformation
#5
Aishani Ghosal, Binny J Cherayil
This paper is broadly concerned with the dynamics of a polymer confined to a rectangular slit of width D and deformed by a planar elongational flow of strength γ̇. It is interested, more specifically, in the nature of the coil-stretch transition that such polymers undergo when the flow strength γ̇ is varied, and in the degree to which this transition is affected by the presence of restrictive boundaries. These issues are explored within the framework of a finitely extensible Rouse model that includes pre-averaged surface-mediated hydrodynamic interactions...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28810686/sampling-efficiency-and-performance-of-selected-thoracic-aerosol-samplers
#6
Peter Görner, Xavier Simon, Alexis Boivin, Sébastien Bau
Measurement of worker exposure to a thoracic health-related aerosol fraction is necessary in a number of occupational situations. This is the case of workplaces with atmospheres polluted by fibrous particles, such as cotton dust or asbestos, and by particles inducing irritation or bronchoconstriction such as acid mists or flour dust. Three personal and two static thoracic aerosol samplers were tested under laboratory conditions. Sampling efficiency with respect to particle aerodynamic diameter was measured in a horizontal low wind tunnel and in a vertical calm air chamber...
August 1, 2017: Annals of Work Exposures and Health
https://www.readbyqxmd.com/read/28809723/nitroglycerin-derived-pd-pa-for-the-assessment-of-intermediate-coronary-lesions
#7
Zeev Israeli, Rodrigo Bagur, Dorian Murariu, Sabrina Wall, Mistre Alemayehu, Yasir Parviz, Pantelis Diamantouros, Shahar Lavi
OBJECTIVES: To assess the predictive value of Pd/Pa after nitroglycerin administration (Pd/Pa[N]) as compared with standard fractional flow reserve (FFR). METHODS: Consecutive patients with intermediate coronary lesions assessed by FFR between January 2014 and October 2015 were included. We measured Pd/Pa at baseline, Pd/Pa(N), and Pd/Pa after incremental doses of intracoronary adenosine. RESULTS: A total of 134 patients (27% females; mean age, 65 years) were included...
August 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28808841/prognostic-significance-of-myocardial-energy-expenditure-and-myocardial-efficiency-in-patients-with-heart-failure-with-reduced-ejection-fraction
#8
Mehmet S Cetin, Elif H Ozcan Cetin, Ugur Canpolat, Hatice Sasmaz, Ahmet Temizhan, Sinan Aydogdu
In heart failure with reduced ejection fraction (HFrEF) patients, myocardial blood flow (MBF), myocardial energy expenditure (MEE), myocardial efficiency has been poorly evaluated because of the necessity of invasive procedures in the determination of these parameters. Transthoracic echocardiography (TTE) can provide reliable data for MEE, MBF (via coronary sinus (CS) flows). Also, myocardial efficiency can be evaluated by the MEE to MBF ratio. We aim to assess MBF, MEE and energy efficiency and the prognostic value of these parameters in HFrEF...
August 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28806532/the-impact-of-an-acute-oral-phosphate-load-on-endothelium-dependent-and-independent-brachial-artery-vasodilation-in-healthy-males
#9
Brendan M Levac, Michael A Adams, Kyra E Pyke
Serum phosphate levels are associated with cardiovascular morbidity and mortality in the general population and endothelial dysfunction may be mechanistically involved. The purpose of this study was to investigate the effects of acute phosphate supplementation on endothelial-dependent (Flow mediated dilation (FMD)) and -independent (Glyceryl trinitrate (GTN)) vasodilation in young, healthy males. 17 healthy male participants (23±3 years old) were exposed to an oral load of phosphate (PHOS; (liquid supplement containing 1200 mg of phosphorous) and placebo (PLAC) over two experimental days...
August 14, 2017: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/28805032/improving-outcomes-after-cabg-and-pci
#10
EDITORIAL
Robert D Safian
Within 1 year of coronary artery bypass surgery , 64% of percutaneous coronary interventions were performed for graft failure and 36% for native vessel disease. Predictors of graft failure were small diameter of the graft and native vessel, poor distal run-off, and disease distal to the graft. In the near future, cardiac computed tomography angiography (CCTA) and fractional flow reserve by CT (FFRct) will incorporate accurate determination of coronary anatomy and the presence and extent of myocardial ischemia...
August 1, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28803685/quantification-of-pulmonary-regurgitation-by-vector-flow-mapping-in-congenital-heart-patients-after-repair-of-right-ventricular-outflow-obstruction-a-preliminary-study
#11
Ashley Hoi-Man To, Vivian Wing-Yi Li, Ming-Yen Ng, Yiu-Fai Cheung
BACKGROUND: Vector flow mapping (VFM) enables direct visualization of flow pattern and estimation of flow volume. The aim of this study was to determine its accuracy in the quantification of pulmonary regurgitation (PR) in congenital heart patients after repair of right ventricular (RV) outflow obstruction. METHODS: This study comprised two parts: (1) validation of VFM in the quantification of PR in patients with repaired tetralogy of Fallot by cardiac magnetic resonance and (2) clinical application of VFM to determine PR in patients after biventricular repair of pulmonary atresia and stenosis with intact ventricular septum...
August 10, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28802004/comparison-of-antimicrobial-peptide-purification-via-free-flow-electrophoresis-and-gel-filtration-chromatography
#12
Zhi-Jun Xia, Zhen Liu, Fan-Zhi Kong, Liu-Yin Fan, Hua Xiao, Cheng-Xi Cao
Antimicrobial peptides (AMPs) are usually small and cationic biomolecules with broad-spectrum antimicrobial activities against pathogens. Purifying them from complex samples is essential to study their physiochemical properties. In this work, free-flow zone electrophoresis (FFZE) was utilized to purify antimicrobial peptides from yeast fermentation broth. Meanwhile, gel filtration chromatography (GFC) was conducted for comparison. The separation efficiency was evaluated by SDS-PAGE analysis of the fractions from both methods...
August 12, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28801827/rapid-screening-and-identification-of-ace-inhibitors-in-snake-venoms-using-at-line-nanofractionation-lc-ms
#13
Marija Mladic, Tessa de Waal, Lindsey Burggraaff, Julien Slagboom, Govert W Somsen, Wilfried M A Niessen, R Manjunatha Kini, Jeroen Kool
This study presents an analytical method for the screening of snake venoms for inhibitors of the angiotensin-converting enzyme (ACE) and a strategy for their rapid identification. The method is based on an at-line nanofractionation approach, which combines liquid chromatography (LC), mass spectrometry (MS), and pharmacology in one platform. After initial LC separation of a crude venom, a post-column flow split is introduced enabling parallel MS identification and high-resolution fractionation onto 384-well plates...
August 11, 2017: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/28800845/assessment-of-stability-of-cd34-cell-products-enriched-by-immunoselection-from-peripheral-blood-mononuclear-cells-during-refrigerated-storage
#14
Metka Krasna, Elvira Malicev, Jasmina Ziva Rozman, Bojan Vrtovec
Durable engraftment of transplanted CD34+ cells largely depends on the quality of the cell product. Limited data are currently available about extended storage of immunoselected CD34+ cells. The aim of our study was to assess the stability of CD34+ cell product with the cells stored in high concentration (80×10(6) in 6mL) in small bags intended for cell implantation. Cell products were prepared by leukapheresis and immunoselection (Clinimacs(plus) procedure) from 13 patients with chronic dilated cardiomyopathy...
July 22, 2017: Transfusion and Apheresis Science
https://www.readbyqxmd.com/read/28800775/lack-of-high-bmi-related-features-in-adipocytes-and-inflammatory-cells-in-the-infrapatellar-fat-pad-ifp
#15
Anja J de Jong, Inge R Klein-Wieringa, Stefan N Andersen, Joanneke C Kwekkeboom, Linda Herb-van Toorn, Badelog J E de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J L van der Heide, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch, Annemarie M Zuurmond, Vedrana Stojanovic-Susulic, Rob G H H Nelissen, René E M Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
BACKGROUND: Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and molecular body mass index (BMI)-related features in the IFP of OA patients. METHODS: Patients with knee OA (N = 155, 68% women, mean age 65 years, mean (SD) BMI 29...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28800175/mesenchymal-stromal-cells-contribute-to-quiescence-of-therapy-resistant-leukemic-cells-in-acute-myeloid-leukemia
#16
Wenwen Wang, Tilmann Bochtler, Patrick Wuchter, Linda Manta, Haiju He, Volker Eckstein, Anthony D Ho, Christoph Lutz
OBJECTIVE: Persistence of leukemic cells after induction therapy has been shown to correlate with poor survival in acute myeloid leukemia (AML). In this study we tested if human mesenchymal stromal cells (hMSC) have protective effects on leukemic cells undergoing chemotherapy. METHODS: Persistent disease was used as marker to identify cases with therapy resistant leukemic cells in 95 AML patients. Immunophenotyping, cell cycle and apoptosis assays were assessed by flow-cytometry...
August 11, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/28799978/role-of-fractional-flow-reserve-in-the-evaluation-and-management-of-patients-with-acute-coronary-syndrome
#17
Abdul Hakeem, Ahmed Almomani, Barry F Uretsky
PURPOSE OF REVIEW: The aim of this review is to appraise the clinical and prognostic value and pitfalls of FFR across different spectra of ACS presentations and lesion subsets. RECENT FINDINGS: Preponderance of evidence on this subject is from observational nonrandomized studies with conflicting results and short-term outcomes. Multiple recent studies evaluating the role of FFR-based deferral in non-STE ACS from a potentially culprit lesion have demonstrated poor long-term prognosis as related to future risk of target vessel failure (myocardial infarction/revascularization)...
August 10, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28798968/stretching-of-surface-tethered-polymers-in-pressure-driven-flow-under-confinement
#18
Tamal Roy, Kai Szuttor, Jens Smiatek, Christian Holm, Steffen Hardt
We study the effect of pressure-driven flow on a single surface-tethered DNA molecule confined between parallel surfaces. The influence of flow and channel parameters as well as the length of the molecules on their extension and orientation is explored. In the experiments the chain conformations are imaged by laser scanning confocal microscopy. We find that the fractional extension of the tethered DNA molecules mainly depends on the wall shear stress, with effects of confinement being very weak. Experiments performed with molecules of different contour length show that the fractional extension is a universal function of the product of the wall shear stress and the contour length, a result that can be obtained from a simple scaling relation...
August 11, 2017: Soft Matter
https://www.readbyqxmd.com/read/28798781/association-of-coronary-ischemia-estimated-by-fractional-flow-reserve-and-psychological-characteristics-of-patients
#19
Miodrag Jovan Sreckovic, Nikola Jagic, Vladimir Miloradovic, Aleksandar Neskovic, Ivan Soldatovic, Ilija Srdanovic
INTRODUCTION: Psychological characteristics of patients, depression, stress and anxiety are recognized as important confounding risk factors for ischemic heart disease. However, the impact of psychological characteristics on coronary ischemia and vice versa remain poorly understood. AIM: To demonstrate the interplay of psychological characteristics, depression, stress and anxiety with coronary ischemia estimated with fractional flow reserve (FFR). MATERIAL AND METHODS: From 2014 to 2016, 147 patients who were planned for FFR measurement were included in this study...
2017: Postępy W Kardiologii Interwencyjnej, Advances in Interventional Cardiology
https://www.readbyqxmd.com/read/28797664/investigation-of-zinc-oxide-particles-in-cosmetic-products-by-means-of-centrifugal-and-asymmetrical-flow-field-flow-fractionation
#20
Vanessa Sogne, Florian Meier, Thorsten Klein, Catia Contado
The dimensional characterization of insoluble, inorganic particles, such as zinc oxide ZnO, dispersed in cosmetic or pharmaceutical formulations, is of great interest considering the current need of declaring the possible presence of nanomaterials on the label of commercial products. This work compares the separation abilities of Centrifugal- and Asymmetrical Flow Field-Flow Fractionation techniques (CF3 and AF4, respectively), equipped with UV-vis, MALS and DLS detectors, in size sorting ZnO particles, both as pristine powders and after their extraction from cosmetic matrices...
August 1, 2017: Journal of Chromatography. A
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