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https://www.readbyqxmd.com/read/29675585/saddle-slow-manifolds-and-canard-orbits-in-formula-see-text-and-application-to-the-full-hodgkin-huxley-model
#1
Cris R Hasan, Bernd Krauskopf, Hinke M Osinga
Many physiological phenomena have the property that some variables evolve much faster than others. For example, neuron models typically involve observable differences in time scales. The Hodgkin-Huxley model is well known for explaining the ionic mechanism that generates the action potential in the squid giant axon. Rubin and Wechselberger (Biol. Cybern. 97:5-32, 2007) nondimensionalized this model and obtained a singularly perturbed system with two fast, two slow variables, and an explicit time-scale ratio ε...
April 19, 2018: Journal of Mathematical Neuroscience
https://www.readbyqxmd.com/read/29675577/dna-in-squid-synaptosomes
#2
Carolina Cefaliello, Marina Prisco, Marianna Crispino, Antonio Giuditta
The synthesis of brain metabolic DNA (BMD) is modulated by learning and circadian oscillations and is not involved in cell division or DNA repair. Data from rats have highlighted its prevalent association with the mitochondrial fraction and its lack of identity with mtDNA. These features suggested that BMD could be localized in synaptosomes that are the major contaminants of brain mitochondrial fractions. The hypothesis has been examined by immunochemical analyses of the large synaptosomes of squid optic lobes that are readily prepared and identified...
April 19, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29674960/emergence-of-relaxation-oscillations-in-neurons-interacting-with-non-stationary-ambient-gaba
#3
Denis A Adamchik, Valery V Matrosov, Victor B Kazantsev
Dynamics of a homogeneous neural population interacting with active extracellular medium were considered. The corresponding mathematical model was tuned specifically to describe the behavior of interneurons with tonic GABA conductance under the action of non-stationary ambient GABA. The feedback provided by the GABA mediated transmembrane current enriched the repertoire of population activity by enabling the oscillatory behavior. This behavior appeared in the form of relaxation oscillations which can be considered as a specific type of brainwaves...
2018: Frontiers in Computational Neuroscience
https://www.readbyqxmd.com/read/29674729/in-vitro-cortical-network-firing-is-homeostatically-regulated-a-model-for-sleep-regulation
#4
Sohrab Saberi-Moghadam, Alessandro Simi, Hesam Setareh, Cyril Mikhail, Mehdi Tafti
Prolonged wakefulness leads to a homeostatic response manifested in increased amplitude and number of electroencephalogram (EEG) slow waves during recovery sleep. Cortical networks show a slow oscillation when the excitatory inputs are reduced (during slow wave sleep, anesthesia), or absent (in vitro preparations). It was recently shown that a homeostatic response to electrical stimulation can be induced in cortical cultures. Here we used cortical cultures grown on microelectrode arrays and stimulated them with a cocktail of waking neuromodulators...
April 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29671707/prediction-of-cognitive-performance-and-subjective-sleepiness-using-a-model-of-arousal-dynamics
#5
Svetlana Postnova, Steven W Lockley, Peter A Robinson
A model of arousal dynamics is applied to predict objective performance and subjective sleepiness measures, including lapses and reaction time on a visual Performance Vigilance Test (vPVT), performance on a mathematical addition task (ADD), and the Karolinska Sleepiness Scale (KSS). The arousal dynamics model is comprised of a physiologically based flip-flop switch between the wake- and sleep-active neuronal populations and a dynamic circadian oscillator, thus allowing prediction of sleep propensity. Published group-level experimental constant routine (CR) and forced desynchrony (FD) data are used to calibrate the model to predict performance and sleepiness...
April 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29671706/circadian-regulation-of-mitochondrial-dynamics-in-retinal-photoreceptors
#6
Janet Ya-An Chang, Liheng Shi, Michael L Ko, Gladys Y-P Ko
Energy expenditure and metabolism in the vertebrate retina are under circadian control, as we previously reported that the overall retinal ATP content and various signaling molecules related to metabolism display daily or circadian rhythms. Changes in the fission and fusion process of mitochondria, the major organelles producing ATP, in retinal photoreceptors are largely dependent on light exposure, but whether mitochondrial dynamics in photoreceptors and retinal neurons are under circadian control is not clear...
April 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29671055/a-new-perspective-of-the-hippocampus-in-the-origin-of-exercise-brain-interactions
#7
REVIEW
Catarina Rendeiro, Justin S Rhodes
Exercising regularly is a highly effective strategy for maintaining cognitive health throughout the lifespan. Over the last 20 years, many molecular, physiological and structural changes have been documented in response to aerobic exercise training in humans and animals, particularly in the hippocampus. However, how exercise produces such neurological changes remains elusive. A recent line of investigation has suggested that muscle-derived circulating factors cross into the brain and may be the key agents driving enhancement in synaptic plasticity and hippocampal neurogenesis from aerobic exercise...
April 18, 2018: Brain Structure & Function
https://www.readbyqxmd.com/read/29666271/desynchronization-of-slow-oscillations-in-the-basal-ganglia-during-natural-sleep
#8
Aviv D Mizrahi-Kliger, Alexander Kaplan, Zvi Israel, Hagai Bergman
Slow oscillations of neuronal activity alternating between firing and silence are a hallmark of slow-wave sleep (SWS). These oscillations reflect the default activity present in all mammalian species, and are ubiquitous to anesthesia, brain slice preparations, and neuronal cultures. In all these cases, neuronal firing is highly synchronous within local circuits, suggesting that oscillation-synchronization coupling may be a governing principle of sleep physiology regardless of anatomical connectivity. To investigate whether this principle applies to overall brain organization, we recorded the activity of individual neurons from basal ganglia (BG) structures and the thalamocortical (TC) network over 70 full nights of natural sleep in two vervet monkeys...
April 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29664924/evidence-supporting-a-role-for-astrocytes-in-the-regulation-of-cognitive-flexibility-and-neuronal-oscillations-through-the-ca2-binding-protein-s100%C3%AE
#9
Adam T Brockett, Gary A Kane, Patrick K Monari, Brandy A Briones, Pierre-Antoine Vigneron, Gabriela A Barber, Andres Bermudez, Uma Dieffenbach, Alexander D Kloth, Timothy J Buschman, Elizabeth Gould
The medial prefrontal cortex (mPFC) is important for cognitive flexibility, the ability to switch between two task-relevant dimensions. Changes in neuronal oscillations and alterations in the coupling across frequency ranges have been correlated with attention and cognitive flexibility. Here we show that astrocytes in the mPFC of adult male Sprague Dawley rats, participate in cognitive flexibility through the astrocyte-specific Ca2+ binding protein S100β, which improves cognitive flexibility and increases phase amplitude coupling between theta and gamma oscillations...
2018: PloS One
https://www.readbyqxmd.com/read/29664887/%C3%AE-aminobutyric-acid-type-a-receptor-potentiation-inhibits-learning-in-a-computational-network-model
#10
Kingsley P Storer, George N Reeke
BACKGROUND: Propofol produces memory impairment at concentrations well below those abolishing consciousness. Episodic memory, mediated by the hippocampus, is most sensitive. Two potentially overlapping scenarios may explain how γ-aminobutyric acid receptor type A (GABAA) potentiation by propofol disrupts episodic memory-the first mediated by shifting the balance from excitation to inhibition while the second involves disruption of rhythmic oscillations. We use a hippocampal network model to explore these scenarios...
April 17, 2018: Anesthesiology
https://www.readbyqxmd.com/read/29662216/cortical-drive-and-thalamic-feed-forward-inhibition-control-thalamic-output-synchrony-during-absence-seizures
#11
Cian McCafferty, François David, Marcello Venzi, Magor L Lőrincz, Francis Delicata, Zoe Atherton, Gregorio Recchia, Gergely Orban, Régis C Lambert, Giuseppe Di Giovanni, Nathalie Leresche, Vincenzo Crunelli
Behaviorally and pathologically relevant cortico-thalamo-cortical oscillations are driven by diverse interacting cell-intrinsic and synaptic processes. However, the mechanism that gives rise to the paroxysmal oscillations of absence seizures (ASs) remains unknown. Here we report that, during ASs in behaving animals, cortico-thalamic excitation drives thalamic firing by preferentially eliciting tonic rather than T-type Ca 2+ channel (T-channel)-dependent burst firing in thalamocortical (TC) neurons and by temporally framing thalamic output via feedforward reticular thalamic (NRT)-to-TC neuron inhibition...
April 16, 2018: Nature Neuroscience
https://www.readbyqxmd.com/read/29661904/increased-cerebral-functional-connectivity-in-als-a-resting-state-magnetoencephalography-study
#12
Malcolm Proudfoot, Giles L Colclough, Andrew Quinn, Joanne Wuu, Kevin Talbot, Michael Benatar, Anna C Nobre, Mark W Woolrich, Martin R Turner
OBJECTIVE: We sought to assess cortical function in amyotrophic lateral sclerosis (ALS) using noninvasive neural signal recording. METHODS: Resting-state magnetoencephalography was used to measure power fluctuations in neuronal oscillations from distributed cortical parcels in 24 patients with ALS and 24 healthy controls. A further 9 patients with primary lateral sclerosis and a group of 15 asymptomatic carriers of genetic mutations associated with ALS were also studied...
April 17, 2018: Neurology
https://www.readbyqxmd.com/read/29660400/hippocampal-coupling-with-cortical-and-subcortical-structures-in-the-context-of-memory-consolidation
#13
Ivan Skelin, Scott Kilianski, Bruce L McNaughton
Memory consolidation is a gradual process through which episodic memories become incorporated into long-term 'semantic' representations. It likely involves reactivation of neural activity encoding the recent experience during non-REM sleep. A critical prerequisite for memory consolidation is precise coordination of reactivation events between the hippocampus and cortical/subcortical structures, facilitated by the coupling of local field potential (LFP) oscillations (slow oscillations, sleep spindles and sharp wave/ripples) between these structures...
April 13, 2018: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29657115/novelty-sensitive-dopaminergic-neurons-in-the-human-substantia-nigra-predict-success-of-declarative-memory-formation
#14
Jan Kamiński, Adam N Mamelak, Kurtis Birch, Clayton P Mosher, Michele Tagliati, Ueli Rutishauser
The encoding of information into long-term declarative memory is facilitated by dopamine. This process depends on hippocampal novelty signals, but it remains unknown how midbrain dopaminergic neurons are modulated by declarative-memory-based information. We recorded individual substantia nigra (SN) neurons and cortical field potentials in human patients performing a recognition memory task. We found that 25% of SN neurons were modulated by stimulus novelty. Extracellular waveform shape and anatomical location indicated that these memory-selective neurons were putatively dopaminergic...
April 7, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29655659/a-v1143f-mutation-in-the-neuronal-enriched-isoform-2-of-the-pmca-pump-is-linked-with-ataxia
#15
Mattia Vicario, Ginevra Zanni, Francesca Vallese, Filippo Santorelli, Alessandro Grinzato, Domenico Cieri, Paola Berto, Martina Frizzarin, Raffaele Lopreiato, Francesco Zonta, Stefania Ferro, Michele Sandre, Oriano Marin, Maria Ruzzene, Enrico Bertini, Giuseppe Zanotti, Marisa Brini, Tito Calì, Ernesto Carafoli
The fine regulation of intracellular calcium is fundamental for all eukaryotic cells. In neurons, Ca2+ oscillations govern the synaptic development, the release of neurotransmitters and the expression of several genes. Alterations of Ca2+ homeostasis were found to play a pivotal role in neurodegenerative progression. The maintenance of proper Ca2+ signaling in neurons demands the continuous activity of Ca2+ pumps and exchangers to guarantee physiological cytosolic concentration of the cation. The plasma membrane Ca2+ ATPases (PMCA pumps) play a key role in the regulation of Ca2+ handling in selected sub-plasma membrane microdomains...
April 12, 2018: Neurobiology of Disease
https://www.readbyqxmd.com/read/29628373/hippocampal-neural-circuits-respond-to-optogenetic-pacing-of-theta-frequencies-by-generating-accelerated-oscillation-frequencies
#16
Ipshita Zutshi, Mark P Brandon, Maylin L Fu, Macayla L Donegan, Jill K Leutgeb, Stefan Leutgeb
Biological oscillations can be controlled by a small population of rhythmic pacemaker cells, or in the brain, they also can emerge from complex cellular and circuit-level interactions. Whether and how these mechanisms are combined to give rise to oscillatory patterns that govern cognitive function are not well understood. For example, the activity of hippocampal networks is temporally coordinated by a 7- to 9-Hz local field potential (LFP) theta rhythm, yet many individual cells decouple from the LFP frequency to oscillate at frequencies ∼1 Hz higher...
April 3, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29625122/periodic-regulation-of-expression-of-genes-for-kisspeptin-gonadotropin-inhibitory-hormone-and-their-receptors-in-the-grass-puffer-implications-in-seasonal-daily-and-lunar-rhythms-of-reproduction
#17
REVIEW
Hironori Ando, Shahjahan, Takashi Kitahashi
The seasonal, daily and lunar control of reproduction involves photoperiodic, circadian and lunar changes in the activity of kisspeptin, gonadotropin-inhibitory hormone (GnIH) and gonadotropin-releasing hormone (GnRH) neurons. These changes are brought through complex networks of light-, time- and non-photic signal-dependent control mechanisms, which are mostly unknown at present. The grass puffer, Takifugu alboplumbeus, a semilunar spawner, provides a unique and excellent animal model to assess this question because its spawning is synchronized with seasonal, daily and lunar cycles...
April 3, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29620525/shared-rhythmic-subcortical-gabaergic-input-to-the-entorhinal-cortex-and-presubiculum
#18
Tim James Viney, Minas Salib, Abhilasha Joshi, Gunes Unal, Naomi Berry, Peter Somogyi
Rhythmic theta frequency (~5-12 Hz) oscillations coordinate neuronal synchrony and higher frequency oscillations across the cortex. Spatial navigation and context-dependent episodic memories are represented in several interconnected regions including the hippocampal and entorhinal cortices, but the cellular mechanisms for their dynamic coupling remain to be defined. Using monosynaptically-restricted retrograde viral tracing in mice, we identified a subcortical GABAergic input from the medial septum that terminated in the entorhinal cortex, with collaterals innervating the dorsal presubiculum...
April 5, 2018: ELife
https://www.readbyqxmd.com/read/29619407/theta-oscillations-organize-spiking-activity-in-higher-order-visual-thalamus-during-sustained-attention
#19
Chunxiu Yu, Yuhui Li, Iain M Stitt, Zhe Charles Zhou, Kristin K Sellers, Flavio Frohlich
Higher-order visual thalamus plays a fundamental but poorly understood role in attention-demanding tasks. To investigate how neuronal dynamics in higher-order visual thalamus are modulated by sustained attention, we performed multichannel electrophysiological recordings in the lateral posterior-pulvinar complex (LP/pulvinar) in the ferret ( Mustela putorius furo ). We recorded single unit activity and local field potential (LFP) during the performance of the five-choice serial reaction time task (5-CSRTT), which is used in both humans and animals as an assay of sustained attention...
January 2018: ENeuro
https://www.readbyqxmd.com/read/29616382/phase-model-based-neuron-stabilization-into-arbitrary-clusters
#20
Timothy D Matchen, Jeff Moehlis
Deep brain stimulation (DBS) is a common method of combating pathological conditions associated with Parkinson's disease, Tourette syndrome, essential tremor, and other disorders, but whose mechanisms are not fully understood. One hypothesis, supported experimentally, is that some symptoms of these disorders are associated with pathological synchronization of neurons in the basal ganglia and thalamus. For this reason, there has been interest in recent years in finding efficient ways to desynchronize neurons that are both fast-acting and low-power...
April 3, 2018: Journal of Computational Neuroscience
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