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Narrow band imaging lung

Manish Advani, Gopal Purohit, Sunil Vyas, Jyoti Kumari
BACKGROUND: Worldwide, lung cancer is the largest contributor to new cancer diagnoses and to death from cancer. Narrow band imaging (NBI) is a novel bronchoscopic technique which enables detailed examination of submucosal microcapillary grid and showed great potential in early detection of malignant lesions of the bronchial mucosa. The aim of this study was to compare diagnostic potential of NBI bronchoscopy over white light (WL) bronchoscopy in lung cancer. METHODS: We enrolled 187 patients having clinical and radiologic findings highly suspicious of lung cancer...
April 2018: Journal of Bronchology & Interventional Pulmonology
Weihang Zhang, Xue Wang, Pengbo Zhang, Junfeng Chen
Lung segmentation on thoracic CT images plays an important role in early detection, diagnosis and 3D visualization of lung cancer. The segmentation accuracy, stability, and efficiency of serial CT scans have a significant impact on the performance of computer-aided detection. This paper proposes a global optimal hybrid geometric active contour model for automated lung segmentation on CT images. Firstly, the combination of global region and edge information leads to high segmentation accuracy in lung regions with weak boundaries or narrow bands...
October 12, 2017: Computers in Biology and Medicine
Tzu-Heng Chen, Wei-Lung Tseng
This study describes a bottom-up assembly route for monodisperse carbon dots (CDs) into different sizes of CD aggregates through the control of the concentration of fatty acids. The highly monodisperse CDs were prepared via solvent-thermal treatment of edible soybean oil, which generated glycerol-based polymer as a carbon source and fatty acid as a surface capping in the synthetic process. The as-synthesized CDs exhibited small particle size variation (2.7 ± 0.2 nm) and narrow emission bands (full width at half-maximum <20 nm)...
November 7, 2017: Analytical Chemistry
Simone Scarlata, Lello Fuso, Gabriele Lucantoni, Francesco Varone, Daniele Magnini, Raffaele Antonelli Incalzi, Gianni Galluccio
More than half of primary lung cancers are not resectable at diagnosis and 40% of deaths may be secondary to loco-regional disease. Many of these patients suffer from symptoms related to airways obstruction. Indications for therapeutic endoscopic treatment are palliation of dyspnea and other obstructive symptoms in advanced cancerous lesions and cure of early lung cancer. Bronchoscopic management is also indicated for all those patients suffering from benign or minimally invasive neoplasm who are not suitable for surgery due to their clinical conditions...
August 2017: Journal of Thoracic Disease
Soudeh Saien, Hamid Abrishami Moghaddam, Mohsen Fathian
PURPOSE: This work aims to develop a unified methodology for the false positives reduction in lung nodules computer-aided detection schemes. METHODS: The 3D region of each detected nodule candidate is first reconstructed using the sparse field method for accurately segmenting the objects. This technique enhances the level set modeling by restricting the computations to a narrow band near the evolving curve. Then, a set of 2D and 3D relevant features are extracted for each segmented candidate...
March 2018: International Journal of Computer Assisted Radiology and Surgery
Juanjuan Zhu, Wei Li, Jihong Zhou, Yuqing Chen, Chenling Zhao, Ting Zhang, Wenjia Peng, Xiaojing Wang
This study aimed to compare the ability of narrow-band imaging to detect early and invasive lung cancer with that of conventional pathological analysis and white-light bronchoscopy. We searched the PubMed, EMBASE, Sinomed, and China National Knowledge Infrastructure databases for relevant studies. Meta-disc software was used to perform data analysis, meta-regression analysis, sensitivity analysis, and heterogeneity testing, and STATA software was used to determine if publication bias was present, as well as to calculate the relative risks for the sensitivity and specificity of narrow-band imaging vs those of white-light bronchoscopy for the detection of early and invasive lung cancer...
July 2017: Clinics
Rimoun Hakim, Bruce Sabath, Tugba Kaplan, Rex Yung
Narrow band imaging (NBI) has been widely applied for the evaluation of numerous disease conditions that present with increased vascularity of the mucosa, most often malignancies. It is increasingly being used in benign conditions as well. We present the first case in which NBI was used, rather, to detect areas of bronchial hypovascularity due to its ability to increase the visual contrast between normal and hypovascular mucosa. Endobronchial biopsy of these nodules led to the diagnosis of sarcoidosis. Had conventional white light alone been utilized, the diagnosis would likely have been missed because not only were these lesions difficult to visualize under white light but transbronchial lung biopsy and transbronchial needle aspiration were unremarkable...
October 2017: Journal of Bronchology & Interventional Pulmonology
Marco Andolfi, Rossella Potenza, Rosanna Capozzi, Valeria Liparulo, Francesco Puma, Kazuhiro Yasufuku
Lung cancer is the leading cause of cancer-related deaths worldwide with an overall 5-year survival rate of 17% after diagnoses. Indeed many patients tend to have a very poor prognosis, due to being diagnosed at an advanced stage. Conversely patients who are diagnosed at an early stage have a 5-year survival >70%, indicating that early detection of lung cancer is crucial to improve survival. Although flexible bronchoscopy is a relatively non-invasive procedure for patients suspected of having lung cancer, only 29% of carcinoma in situ (CIS) and 69% of microinvasive tumors were detectable using white light bronchoscopy (WLB) alone...
November 2016: Journal of Thoracic Disease
Jianrong Zhang, Jieyu Wu, Yujing Yang, Hua Liao, Zhiheng Xu, Lindsey Tristine Hamblin, Long Jiang, Lieven Depypere, Keng Leong Ang, Jiaxi He, Ziyan Liang, Jun Huang, Jingpei Li, Qihua He, Wenhua Liang, Jianxing He
BACKGROUND: We aimed to summarize the diagnostic accuracy of white light bronchoscopy (WLB) and advanced techniques for airway pre-cancerous lesions and early cancer, such as autofluorescence bronchoscopy (AFB), AFB combined with WLB (AFB + WLB) and narrow-band imaging (NBI) bronchoscopy. METHODS: We searched for eligible studies in seven electronic databases from their date of inception to Mar 20, 2015. In eligible studies, detected lesions should be confirmed by histopathology...
November 2016: Journal of Thoracic Disease
Philipp Hofemeier, Josué Sznitman
Lung deformations at the local pulmonary acinar scale are intrinsically anisotropic. Despite progress in imaging modalities, the true heterogeneous nature of acinar expansion during breathing remains controversial, where our understanding of inhaled aerosol deposition still widely emanates from studies under self-similar, isotropic wall motions. Building on recent 3D models of multi-generation acinar networks, we explore in numerical simulations how different hypothesized scenarios of anisotropic expansion influence deposition outcomes of inhaled aerosols in the acinar depths...
October 3, 2016: Journal of Biomechanics
Anna Kołodziej, Wojciech Krajewski, Michał Matuszewski, Krzysztof Tupikowski
INTRODUCTION: Urinary bladder urothelial cell carcinoma is one of the most commonly diagnosed cancers in Europe. After prostate, lung and colon cancers, bladder cancer rates as the fourth most common cancer in men in the world. Urinary bladder cancer detection, treatment, and staging have traditionally been based on an endoscopic examination - cystoscopy. MATERIAL AND METHODS: A Medline, and Web of Science database search was performed on September 2015 without setting time limits, using the terms 'bladder cancer' in conjunction with 'cystoscopy', 'diagnosis', 'detection', 'fluorescence', 'blue-light', 'PDD', 'narrow band imaging', 'molecular imaging', 'optical coherence tomography' or 'confocal laser endomicroscopy'...
2016: Central European Journal of Urology
Zhan Zhou, Qianming Wang, Cheng Cheng Zhang, Jinwei Gao
In this research, a novel terbium-based luminescent hybrid inorganic/organic probe was designed and synthesized. Mesoporous silica nanospheres dispersed in water were used as the appropriate host for the covalently linked lanthanide-containing organic structures. The lanthanide structure was linked to a sulfonate ester unit, which, in the presence of biothiols, was cleaved to result in terbium emission. The hybrid probe exhibited the capabilities of quantitative determination and detection limits for biothiols were presented (36...
April 25, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Alejandro H Sardi, Shaheen Islam
PURPOSE OF REVIEW: Lung cancer is the leading cause of cancer deaths worldwide. Early detection is essential for long-term survival. Screening of high-risk individuals with low-dose computed tomography screening has proven to increase survival. However, current radiological imaging techniques have poor specificity for lung cancer detection and poor sensitivity for detection of mucosal or alveolar preinvasive malignant lesions. Bronchoscopy allows imaging and sampling of early lung cancer, with the highest safety profile and high diagnostic accuracy...
May 2016: Current Opinion in Pulmonary Medicine
Caixia Yue, Chunlei Zhang, Gabriel Alfranca, Yao Yang, Xinquan Jiang, Yuming Yang, Fei Pan, Jesús M de la Fuente, Daxiang Cui
Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release. However, few report is associated with the ROS responsive drug controlled release. Herein, a thioketal linker-based ROS responsive drug (camptothecin conjugated with thioketal linker, abbreviated as TL-CPT) was prepared and the thioketal linker could be cleaved by ROS(reactive oxygen species). To achieve cancer simultaneous optical imaging, photodynamic therapy and chemotherapy, the photosensitizer Chlorin e6(Ce6), TL-CPT and carboxyl-mPEG were loaded on the upconversion nanoparticles (UCNPs), which were named as Ce6-CPT-UCNPs...
2016: Theranostics
Liqin Xiong, Fengwen Cao, Xinmin Cao, Yixiao Guo, Yimin Zhang, Xi Cai
Fluorescent nanoprobes have become one of the most promising classes of materials for cancer imaging. However, there remain many unresolved issues with respect to the understanding of their long-term colloidal stability and photostability in both biological systems and the environment. In this study, we report long-term-stable near-infrared (NIR) polymer dots for in vivo tumor vasculature imaging. NIR-emitting polymer dots were prepared by encapsulating an NIR dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775), into a matrix of polymer dots, poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV), using a nanoscale precipitation method...
May 20, 2015: Bioconjugate Chemistry
Ming Li, Takehiro Izumo, Guoliang Zhang, Aimei Peng, Changhui Wang
OBJECTIVE: To determine the sensitivity of narrow-band imaging bronchoscopy (NBI) in the assessment of tumor extent and therapeutic strategy. METHODS: A total of 196 patients with imaging abnormalities for malignancy were examined with both white light bronchoscopy (WLB) and NBI (Olympus, EVIS LUCERA). Record the tumor infiltration, image and pathological results. RESULTS: There were 152 male and 44 female with a mean age of 58 years. In 22 patients (13...
December 2, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Yoshihiro Nakamura, Masami Sato
Endoscopic technology has developed markedly with endobronchial ultrasonography (EBUS) having become dramatically widespread over the past 10 years. EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has become an important modality for the mediastinal staging of lung cancer as well as mediastinoscopy. The combination of EBUS with a guide sheath( EBUS-GS) and virtual navigation systems, such as Bf-NAVI, LungPoint, superDimension/Bronchus system, is useful for diagnosis of small peripheral pulmonary lesions...
July 2014: Kyobu Geka. the Japanese Journal of Thoracic Surgery
Rupananda J Mallia, Patrick Z McVeigh, Carl J Fisher, Israel Veilleux, Brian C Wilson
AIM: As the possibilities of molecular imaging in personalized medicine evolve rapidly, the optical advantages of extremely narrow and intense spectral bands makes surface-enhanced Raman scattering (SERS) an appealing candidate for multiplexed recognition of targeted biomarkers over other optical imaging modalities. MATERIALS & METHODS: In this proof-of-concept study, we report wide-field Raman detection of lung cancer using multimodal SERS nanoprobes specific to the EGF receptor family, both in vitro and in vivo...
January 2015: Nanomedicine
Zhongbo Chen, Yiming Yu, Shifang Sun, Hongying Ma, Qiaoli Zhang, Dan Lyu, Bijiong Wang, Liming Niu, Chao Cao, Qunli Ding, Zaichun Deng
OBJECTIVE: To assess the diagnostic value of narrow-band imaging(NBI) in the diagnosis of central lung cancer. METHODS: Patients (n = 153) suspected of having lung cancer underwent white light bronchoscopy(WLB), NBI and autofluorescence bronchoscopy(AFB) in turn. At least 3 biopsies in each case were taken from sites visualized as lesions. The sensitivity and specificity of NBI, AFB and combination of NBI and AFB were compared. RESULTS: There were 106 male (69...
March 2014: Chinese Journal of Tuberculosis and Respiratory Diseases
Prashanth Thalanayar
SESSION TITLE: Bronchology CasesSESSION TYPE: Case ReportsPRESENTED ON: Sunday, March 23, 2014 at 09:00 AM - 10:00 AMINTRODUCTION: The tracheo-bronchial anatomy is supplied by the superior thyroid and bronchial-pulmonary arterial and venous system which is typically a low pressure system on the venous side. Typical bronchoscopy reveals pink mucosa without visible veins in the sub-mucosal level. CASE PRESENTATION: This case report describes a rare bronchoscopic appearance of the upper and lower respiratory tract of a 43-year-old caucasian male admitted with chest pain and hemoptysis...
March 1, 2014: Chest
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