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https://www.readbyqxmd.com/read/27614613/the-role-of-anisotropic-expansion-for-pulmonary-acinar-aerosol-deposition
#1
Philipp Hofemeier, Josué Sznitman
Lung deformations at the local pulmonary acinar scale are intrinsically anisotropic. Despite progress in imaging modalities, the true heterogeneous nature of acinar expansion during breathing remains controversial, where our understanding of inhaled aerosol deposition still widely emanates from studies under self-similar, isotropic wall motions. Building on recent 3D models of multi-generation acinar networks, we explore in numerical simulations how different hypothesized scenarios of anisotropic expansion influence deposition outcomes of inhaled aerosols in the acinar depths...
October 3, 2016: Journal of Biomechanics
https://www.readbyqxmd.com/read/27551551/review-of-current-optical-diagnostic-techniques-for-non-muscle-invasive-bladder-cancer
#2
REVIEW
Anna Kołodziej, Wojciech Krajewski, Michał Matuszewski, Krzysztof Tupikowski
INTRODUCTION: Urinary bladder urothelial cell carcinoma is one of the most commonly diagnosed cancers in Europe. After prostate, lung and colon cancers, bladder cancer rates as the fourth most common cancer in men in the world. Urinary bladder cancer detection, treatment, and staging have traditionally been based on an endoscopic examination - cystoscopy. MATERIAL AND METHODS: A Medline, and Web of Science database search was performed on September 2015 without setting time limits, using the terms 'bladder cancer' in conjunction with 'cystoscopy', 'diagnosis', 'detection', 'fluorescence', 'blue-light', 'PDD', 'narrow band imaging', 'molecular imaging', 'optical coherence tomography' or 'confocal laser endomicroscopy'...
2016: Central European Journal of Urology
https://www.readbyqxmd.com/read/27041001/molecular-imaging-of-biothiols-and-in-vitro-diagnostics-based-on-an-organic-chromophore-bearing-a-terbium-hybrid-probe
#3
Zhan Zhou, Qianming Wang, Cheng Cheng Zhang, Jinwei Gao
In this research, a novel terbium-based luminescent hybrid inorganic/organic probe was designed and synthesized. Mesoporous silica nanospheres dispersed in water were used as the appropriate host for the covalently linked lanthanide-containing organic structures. The lanthanide structure was linked to a sulfonate ester unit, which, in the presence of biothiols, was cleaved to result in terbium emission. The hybrid probe exhibited the capabilities of quantitative determination and detection limits for biothiols were presented (36...
April 25, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/26986175/early-lung-cancer-detection-mucosal-and-alveolar-imaging
#4
REVIEW
Alejandro H Sardi, Shaheen Islam
PURPOSE OF REVIEW: Lung cancer is the leading cause of cancer deaths worldwide. Early detection is essential for long-term survival. Screening of high-risk individuals with low-dose computed tomography screening has proven to increase survival. However, current radiological imaging techniques have poor specificity for lung cancer detection and poor sensitivity for detection of mucosal or alveolar preinvasive malignant lesions. Bronchoscopy allows imaging and sampling of early lung cancer, with the highest safety profile and high diagnostic accuracy...
May 2016: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/26941840/near-infrared-light-triggered-ros-activated-theranostic-platform-based-on-ce6-cpt-ucnps-for-simultaneous-fluorescence-imaging-and-chemo-photodynamic-combined-therapy
#5
Caixia Yue, Chunlei Zhang, Gabriel Alfranca, Yao Yang, Xinquan Jiang, Yuming Yang, Fei Pan, Jesús M de la Fuente, Daxiang Cui
Many drug controlled release methods have been integrated in multifunctional nanoparticles, such as pH-, redox-, temperature-, enzyme-, and light-responsive release. However, few report is associated with the ROS responsive drug controlled release. Herein, a thioketal linker-based ROS responsive drug (camptothecin conjugated with thioketal linker, abbreviated as TL-CPT) was prepared and the thioketal linker could be cleaved by ROS(reactive oxygen species). To achieve cancer simultaneous optical imaging, photodynamic therapy and chemotherapy, the photosensitizer Chlorin e6(Ce6), TL-CPT and carboxyl-mPEG were loaded on the upconversion nanoparticles (UCNPs), which were named as Ce6-CPT-UCNPs...
2016: Theranostics
https://www.readbyqxmd.com/read/25928072/long-term-stable-near-infrared-polymer-dots-with-ultrasmall-size-and-narrow-band-emission-for-imaging-tumor-vasculature-in-vivo
#6
Liqin Xiong, Fengwen Cao, Xinmin Cao, Yixiao Guo, Yimin Zhang, Xi Cai
Fluorescent nanoprobes have become one of the most promising classes of materials for cancer imaging. However, there remain many unresolved issues with respect to the understanding of their long-term colloidal stability and photostability in both biological systems and the environment. In this study, we report long-term-stable near-infrared (NIR) polymer dots for in vivo tumor vasculature imaging. NIR-emitting polymer dots were prepared by encapsulating an NIR dye, silicon 2,3-naphthalocyanine bis(trihexylsilyloxide) (NIR775), into a matrix of polymer dots, poly[2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene] (MEH-PPV), using a nanoscale precipitation method...
May 20, 2015: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/25622741/-narrow-band-imaging-bronchoscopy-improves-assessment-of-tumor-extent-and-affects-therapeutic-strategy-for-central-lung-cancer
#7
Ming Li, Takehiro Izumo, Guoliang Zhang, Aimei Peng, Changhui Wang
OBJECTIVE: To determine the sensitivity of narrow-band imaging bronchoscopy (NBI) in the assessment of tumor extent and therapeutic strategy. METHODS: A total of 196 patients with imaging abnormalities for malignancy were examined with both white light bronchoscopy (WLB) and NBI (Olympus, EVIS LUCERA). Record the tumor infiltration, image and pathological results. RESULTS: There were 152 male and 44 female with a mean age of 58 years. In 22 patients (13...
December 2, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/25138942/-diagnostic-bronchoscopy
#8
REVIEW
Yoshihiro Nakamura, Masami Sato
Endoscopic technology has developed markedly with endobronchial ultrasonography (EBUS) having become dramatically widespread over the past 10 years. EBUS-guided transbronchial needle aspiration (EBUS-TBNA) has become an important modality for the mediastinal staging of lung cancer as well as mediastinoscopy. The combination of EBUS with a guide sheath( EBUS-GS) and virtual navigation systems, such as Bf-NAVI, LungPoint, superDimension/Bronchus system, is useful for diagnosis of small peripheral pulmonary lesions...
July 2014: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/25046405/wide-field-multiplexed-imaging-of-egfr-targeted-cancers-using-topical-application-of-nir-sers-nanoprobes
#9
Rupananda J Mallia, Patrick Z McVeigh, Carl J Fisher, Israel Veilleux, Brian C Wilson
AIM: As the possibilities of molecular imaging in personalized medicine evolve rapidly, the optical advantages of extremely narrow and intense spectral bands makes surface-enhanced Raman scattering (SERS) an appealing candidate for multiplexed recognition of targeted biomarkers over other optical imaging modalities. MATERIALS & METHODS: In this proof-of-concept study, we report wide-field Raman detection of lung cancer using multimodal SERS nanoprobes specific to the EGF receptor family, both in vitro and in vivo...
January 2015: Nanomedicine
https://www.readbyqxmd.com/read/24809708/-combination-of-narrow-band-imaging-nbi-and-autofluorescence-bronchoscopy-afb-in-the-assessment-of-central-lung-cancer
#10
Zhongbo Chen, Yiming Yu, Shifang Sun, Hongying Ma, Qiaoli Zhang, Dan Lyu, Bijiong Wang, Liming Niu, Chao Cao, Qunli Ding, Zaichun Deng
OBJECTIVE: To assess the diagnostic value of narrow-band imaging(NBI) in the diagnosis of central lung cancer. METHODS: Patients (n = 153) suspected of having lung cancer underwent white light bronchoscopy(WLB), NBI and autofluorescence bronchoscopy(AFB) in turn. At least 3 biopsies in each case were taken from sites visualized as lesions. The sensitivity and specificity of NBI, AFB and combination of NBI and AFB were compared. RESULTS: There were 106 male (69...
March 2014: Chinese Journal of Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/24638634/stunning-visuals-click-of-a-wrong-button
#11
Prashanth Thalanayar
SESSION TITLE: Bronchology CasesSESSION TYPE: Case ReportsPRESENTED ON: Sunday, March 23, 2014 at 09:00 AM - 10:00 AMINTRODUCTION: The tracheo-bronchial anatomy is supplied by the superior thyroid and bronchial-pulmonary arterial and venous system which is typically a low pressure system on the venous side. Typical bronchoscopy reveals pink mucosa without visible veins in the sub-mucosal level. CASE PRESENTATION: This case report describes a rare bronchoscopic appearance of the upper and lower respiratory tract of a 43-year-old caucasian male admitted with chest pain and hemoptysis...
March 1, 2014: Chest
https://www.readbyqxmd.com/read/24102008/advanced-bronchoscopic-techniques-in-diagnosis-and-staging-of-lung-cancer
#12
REVIEW
Bojan Zaric, Vladimir Stojsic, Tatjana Sarcev, Goran Stojanovic, Vladimir Carapic, Branislav Perin, Paul Zarogoulidis, Kaid Darwiche, Kosmas Tsakiridis, Ilias Karapantzos, Georgios Kesisis, Ioanna Kougioumtzi, Nikolaos Katsikogiannis, Nikolaos Machairiotis, Aikaterini Stylianaki, Christophoros N Foroulis, Konstantinos Zarogoulidis
The role of advanced brochoscopic diagnostic techniques in detection and staging of lung cancer has steeply increased in recent years. Bronchoscopic imaging techniques became widely available and easy to use. Technical improvement led to merging in technologies making autofluorescence or narrow band imaging incorporated into one bronchoscope. New tools, such as autofluorescence imagining (AFI), narrow band imaging (NBI) or fuji intelligent chromo endoscopy (FICE), found their place in respiratory endoscopy suites...
September 2013: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/23934011/differential-diagnosis-of-colorectal-polyps-with-respect-to-similar-capabilities-of-white-light-colonoscopy-and-narrow-band-imaging
#13
Wei-Chih Shen, Shwn-Huey Shieh, Ming-Hung Tsai, Tzu-Liang Kung, Wen-Hsin Huang, Chun-Fu Ting, Chun-Lung Feng
PURPOSE: The responses of polyps to light essentially determine the diagnostic capability of an endoscopy system in differentiating adenomas from hyperplastic polyps. Compared with white light colonoscopy (WLC), narrow-band imaging (NBI) is expected to improve the diagnostic capability. The diagnostic capabilities of WLC and NBI are evaluated and compared based on the polyp responses. METHODS: The following WLC and NBI images were retrospectively reviewed and categorized: 195 images and polyps (89 WLC, 106 NBI) with the best visual quality were categorized in the best image group (BG), and 484 images of 242 polyps (both WLC and NBI) were categorized in the paired image group (PG)...
January 2014: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/23769344/-combination-of-narrow-band-imaging-and-autofluorescence-imaging-videobronchoscopy-in-the-assessment-of-lung-cancer
#14
Zhongbo Chen, Yiming Yu, Shifang Sun, Hongying Ma, Qiaoli Zhang, Dan Lv, Bijiong Wang, Chao Cao, Qunli Ding, Zaichun Deng
BACKGROUND: Narrow-band imaging (NBI) and autofluorescence imaging (AFI) are new bronchoscopy technologies that are important in lung cancer diagnosis. The aim of this study is to determine whether or not the combination of these two technologies can improve sensitivity and specificity of lung cancer diagnosis. METHODS: A total of 137 patients who manifested symptoms of lung cancer were investigated in this project. All of the examinations were performed based on an Olympus Evis Lucera bronchoscopy system...
June 2013: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
https://www.readbyqxmd.com/read/23741271/detection-of-premalignant-bronchial-lesions-can-be-significantly-improved-by-combination-of-advanced-bronchoscopic-imaging-techniques
#15
Bojan Zaric, Branislav Perin, Vladimir Stojsic, Vladimir Carapic, Jovan Matijasevic, Ilija Andrijevic, Zivka Eri
BACKGROUND: The search for the most efficient bronchoscopic imaging tool in detection of early lung cancer is still active. The major aim of this study was to determine sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of each bronchoscopic technique and their combination in detection of premalignant bronchial lesions. METHODS: This was a prospective trial that enrolled 96 patients with indication for bronchoscopy. Lesions were classified as visually positive if pathological fluorescence was observed under autofluorescence imaging (AFI) videobronchoscopy or dotted, tortuous, and abrupt-ending blood vessels were identified under narrow band imaging (NBI) videobronchoscopy...
April 2013: Annals of Thoracic Medicine
https://www.readbyqxmd.com/read/23275117/relation-between-vascular-patterns-visualized-by-narrow-band-imaging-nbi-videobronchoscopy-and-histological-type-of-lung-cancer
#16
Bojan Zaric, Branislav Perin, Vladimir Stojsic, Vladimir Carapic, Zivka Eri, Milana Panjkovic, Ilija Andrijevic, Jovan Matijasevic
Narrow Band Imaging (NBI) videobronchoscopy is a new technique for visualization of microvascular changes in bronchial mucosa. The primary aim of this study was to evaluate relation between vascular patterns visualized by NBI and histology of lung cancer. We prospectively evaluated 65 patients with suspected lung cancer scheduled for bronchoscopy. NBI followed conventional WL videobronchoscopy. After identification of endoscopically visible tumor, NBI was used to determine predominant type of pathological vascular pattern (dotted, tortuous, abrupt-ending blood vessels-Shibuya descriptors)...
March 2013: Medical Oncology
https://www.readbyqxmd.com/read/23258501/bronchoscopic-staging-of-lung-cancer
#17
REVIEW
Waël C Hanna, Kazuhiro Yasufuku
Advances in bronchoscopy have contributed valuable tools to the diagnosis and staging of lung cancer. Detection of lesions at the premalignant microscopic stage has become possible with autofluorescence bronchoscopy and narrow band imaging. Bronchoscopy also allows for sampling of visible intra-bronchial lesions and for transbronchial needle aspiration of lesions in pulmonary parenchyma. With endobronchial ultrasound guidance, real-time evaluation and biopsy of mediastinal and pulmonary lesions can be achieved, enabling accurate clinical and pathological T-staging and N-staging without the need for surgery...
April 2013: Therapeutic Advances in Respiratory Disease
https://www.readbyqxmd.com/read/22712451/interventional-pulmonology-focus-on-pulmonary-diagnostics
#18
REVIEW
Kasia Czarnecka, Kazuhiro Yasufuku
Interventional pulmonology (IP) allows comprehensive assessment of patients with benign and malignant airway, lung parenchymal and pleural disease. This relatively new branch of pulmonary medicine utilizes advanced diagnostic and therapeutic techniques to treat patients with pulmonary diseases. Endobronchial ultrasound revolutionized assessment of pulmonary nodules, mediastinal lymphadenopathy and lung cancer staging allowing minimally invasive, highly accurate assessment of lung parenchymal and mediastinal disease, with both macro- and microscopic tissue characterization including molecular signature analysis...
January 2013: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/22009080/update-on-interventional-bronchoscopy-for-the-thoracic-radiologist
#19
Armin Ernst, Devanand Anantham
Interventional bronchoscopy, together with other domains of interventional pulmonology, has experienced tremendous technological advances. Diagnostic applications include endobronchial ultrasound, which enables endoscopists to see through airway walls. White light videobronchoscopy, autofluorescence imaging, and narrow band imaging have enhanced the ability to detect early lung cancer at a preinvasive stage. Electromagnetic navigational bronchoscopy, ultrathin bronchoscopy, and virtual bronchoscopy increase the diagnostic yield of biopsy of small peripheral lung lesions...
November 2011: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/21826532/combination-of-narrow-band-imaging-nbi-and-autofluorescence-imaging-afi-videobronchoscopy-in-endoscopic-assessment-of-lung-cancer-extension
#20
Bojan Zaric, Branislav Perin, Heinrich D Becker, Felix Fj Herth, Ralf Eberhardt, Svetlana Jovanovic, Tihomir Orlic, Milana Panjkovic, Biljana Zvezdin, Aleksandra Jovelic, Milorad Bijelovic, Vladimir Jurisic, Milan Antonic
Both narrow band imaging (NBI) and autofluorescence imaging (AFI) are new techniques for the assessment of lung cancer. The major aim of this study was to investigate whether the combination of these two techniques improve sensitivity and specificity in the assessment of lung cancer extension. The study prospectively evaluated 118 patients with suspected lung cancer. All of the patients were examined using EVIS LUCERA SPECTRUM videobronchoscopy system. The narrow band imaging preceded autofluorescence imaging examination...
September 2012: Medical Oncology
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