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https://www.readbyqxmd.com/read/28820415/-complications-of-pregnancy-resulting-from-assisted-reproductive-technology
#1
A Aleksanyan
When pregnancy occurs as a result of assisted reproductive technologies (ART), there are more chances of developing complications and adverse outcomes for the mother and fetus compared to spontaneous pregnancies. Taking into account the noted features, the purpose of our study was to determine the nature of the complications of induced pregnancy and their frequency, depending on the causes of infertility. Under our supervision were 86 women with induced single-pregnancy. Two clinical groups were formed depending on the causes of infertility: group I was represented by 53 observations, in which infertility of endocrine genesis took place; Group II included 33 women with tubal peritoneal infertility...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28820408/-thrombophilic-genetic-mutations-and-polymorphisms-in-women-with-infertility-and-failed-in-vitro-fertilization
#2
G Abrahamyan
Occurrence of pregnancy after in vitro fertilization depends of two components: functional adequacy of the embryo at the blastocyst stage and receptivity of endometrium, which, according to modern perception, are determinate in achieving optimal conditions of implantation. From the pregnancy occurrence point of view, as well as in regard to its further development , implantation is the most crucial phase of IVF/ICSI and ET. As the same time, this phase is also the most vulnerable. Multiple researches have proven the role of mother thrombophilia for genesis of gestation complications and early embryo losses, but in relation to this problem i the context of IVF there is still a lot to be detailed...
July 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28816587/dna-methylation-independent-growth-restriction-and-altered-developmental-programming-in-a-mouse-model-of-preconception-male-alcohol-exposure
#3
Richard C Chang, William M Skiles, S Chronister Sarah, Haiqing Wang, Gabrielle I Sutton, Yudhishtar S Bedi, Matthew Snyder, Charles R Long, Michael C Golding
The preconception environment is a significant modifier of dysgenesis and the development of environmentally-induced disease. To date, Fetal Alcohol Spectrum Disorders (FASDs) have been exclusively associated with maternal exposures, yet emerging evidence suggests male-inherited alterations in the developmental program of sperm may be relevant to the growth-restriction phenotypes of this condition. Using a mouse model of voluntary consumption, we find chronic preconception male ethanol exposure associates with fetal growth restriction, decreased placental efficiency, abnormalities in cholesterol trafficking, sex-specific alterations in the genetic pathways regulating hepatic fibrosis, and disruptions in the regulation of imprinted genes...
August 17, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28814327/neocortical-sox9-radial-glia-generate-glutamatergic-neurons-for-all-layers-but-lack-discernible-evidence-of-early-laminar-fate-restriction
#4
E S Kaplan, K A Ramos-Laguna, A B Mihalas, R A M Daza, R F Hevner
Glutamatergic neurons in the cerebral cortex are derived from embryonic neural stem cells known as radial glial progenitors (RGPs). Early RGPs, present at the onset of cortical neurogenesis, are classically thought to produce columnar clones of glutamatergic neurons spanning the cortical layers. Recently, however, it has been reported that a subset of early RGPs may undergo early commitment to upper layer neuron fates, thus bypassing genesis of deep layer neurons. However, the latter mode of early RGP differentiation was not confirmed in some other studies, and remains controversial...
August 16, 2017: Neural Development
https://www.readbyqxmd.com/read/28811644/the-link-between-enso-like-forcing-and-hydroclimate-variability-of-coastal-east-asia-during-the-last-millennium
#5
Jungjae Park, Jiwoo Han, Qiuhong Jin, Junbeom Bahk, Sangheon Yi
Inconsistent reconstructions of East Asian hydroclimate for the last millennium significantly limit our understanding of the mechanisms behind climate variability during the medieval climate anomaly (MCA) and little ice age (LIA) in the region. In this study, we present new high-resolution multiproxy records (diatom, δ(13)C, C/N, TS) from the Mulyoungari swamp, Jeju Island, South Korea. Our results indicate that El Niño southern oscillation-like variations caused the dry MCA/wet LIA pattern in the study area...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28810596/expression-of-kruppel-like-factor-8-and-ki67-in-lung-adenocarcinoma-and-prognosis
#6
Yifei Liu, Xiufang Yao, Qing Zhang, Li Qian, Jia Feng, Tingting Bian, Jianguo Zhang, Ye Tian
Kruppel-like factor 8 (KLF8) belongs to the KLF family and has various roles in the regulation of the cell cycle, proliferation and tumor genesis. KLF8 is overexpressed in gastric, ovarian, breast and renal cancer. Additionally, KLF8 may affect invasion and metastasis of tumors. However, whether KLF8 also acts as an ontogeny in lung adenocarcinoma (LAC) remains unknown. The aim of the present study was to determine the association between KLF8 expression and various clinical and pathological parameters. Western blot assays and immune histochemistry analyses revealed that KLF8 level in LAC tissues was higher than that in the normal lung tissues and KLF8 expression was significantly associated with clinical variables (P<0...
August 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28808898/wilhelm-his-and-mechanistic-approaches-to-development-at-the-time-of-entwicklungsmechanik
#7
Jean-Claude Dupont
At the end of the nineteenth century, approaches from experimental physiology made inroads into embryological research. A new generation of embryologists felt urged to study the mechanisms of organ formation. This new program, most prominently defended by Wilhelm Roux (1850-1924), was called Entwicklungsmechanik. Named variously as "causal embryology", "physiological embryology" or "developmental mechanics", it catalyzed the movement of embryology from a descriptive science to one exploring causal mechanisms...
August 14, 2017: History and Philosophy of the Life Sciences
https://www.readbyqxmd.com/read/28808788/shocks-after-implantable-cardioverter-defibrillator-implantation-in-idiopathic-cardiomyopathy-patients-a-myocardial-biopsy-study
#8
Erdal Safak, Giuseppe D Ancona, Heinz-Peter Schultheiss, Uwe Kühl, Stephan Kische, Hilmi Kaplan, Hüseyin Ince, Jasmin Ortak
Prediction of follow-up shock is crucial to stratify patients with dilated cardiomyopathy (DCM) requiring implantable cardioverter defibrillator (ICD). The objective of the article is to assess the predictive value of endo-myocardial biopsy (EMB) towards ICD shock and follow-up mortality. A series of patients with DCM scheduled for ICD implantation underwent EMB to further determine the genesis of DCM. Presence of fibrosis and inflammation was documented and related to outcomes. A total of 240 patients were referred for ICD as primary (56%) and secondary (44%) prophylaxis...
August 14, 2017: Heart and Vessels
https://www.readbyqxmd.com/read/28808590/genesis-and-maintenance-of-attentional-biases-the-role-of-the-locus-coeruleus-noradrenaline-system
#9
REVIEW
Mana R Ehlers, Rebecca M Todd
Emotionally arousing events are typically better remembered than mundane ones, in part because emotionally relevant aspects of our environment are prioritized in attention. Such biased attentional tuning is itself the result of associative processes through which we learn affective and motivational relevance of cues. We propose that the locus coeruleus-noradrenaline (LC-NA) system plays an important role in the genesis of attentional biases through associative learning processes as well as their maintenance...
2017: Neural Plasticity
https://www.readbyqxmd.com/read/28802936/nonmotor-symptoms-in-experimental-models-of-parkinson-s-disease
#10
Nataliya Titova, Anthony H V Schapira, K Ray Chaudhuri, Mubasher A Qamar, Elena Katunina, Peter Jenner
Nonmotor symptoms of Parkinson's disease (PD) range from neuropsychiatric, cognitive to sleep and sensory disorders and can arise from the disease process as well as from drug treatment. The clinical heterogeneity of nonmotor symptoms of PD is underpinned by a wide range of neuropathological and molecular pathology, affecting almost the entire range of neurotransmitters present in brain and the periphery. Understanding the neurobiology and pathology of nonmotor symptoms is crucial to the effective treatment of PD and currently a key unmet need...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28802237/umbelliferon-%C3%AE-d-glucopyranosyl-2-i-%C3%A2-1-ii-%C3%AE-dglucopyranoside-ameliorates-diethylnitrosamine-induced-precancerous-lesion-development-in-liver-via-regulation-of-inflammation-hyperproliferation-and-antioxidant-at-pre-clinical-stage
#11
Vikas Kumar, Prakash Chandra Bhatt, Mahfoozur Rahman, Fahad A Al-Abbasi, Firoz Anwar, Amita Verma
It is well documented that anomalous production of inflammatory proteins linked with most of the toxic expression and genesis of diverse chronic disease including cancer. Diethylnitrosamine (DEN) a well-known hepatotoxin and hepatocarcinogen, can induce oxidative stress and inflammatory reaction in it. Umbelliferone, secondary metabolites, is present in different plants and widely consumed by humans as medicine and food supplements. The aim of the current study was to scrutinize the chemoprotective potential of umbelliferon-α-d-glucopyranosyl-(2(I)→1(II))-α-d-glucopyranoside (UFD) against DEN-induced hepatocellular carcinoma (HCC) in experimental rats...
August 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28802071/microrna-137-and-195-inhibit-vasculogenesis-in-brain-arteriovenous-malformations
#12
Jun Huang, Jianping Song, Meijie Qu, Yang Wang, Qinzhu An, Yaying Song, Wei Yan, Bingshun Wang, Xiaojin Wang, Song Zhang, Xi Chen, Bing Zhao, Peixi Liu, Tongyi Xu, Zhijun Zhang, David A Greenberg, Yongting Wang, Pingjin Gao, Wei Zhu, Guo-Yuan Yang
OBJECTIVES: Brain arteriovenous malformations (AVMs) are the most common cause of non-traumatic intracerebral hemorrhage in young adults. The genesis of brain AVM remains enigmatic. We investigated microRNA (miRNA) expression and its contribution to the pathogenesis of brain AVMs. METHODS: We used a large-scale miRNA analysis on 16 samples including AVMs, hemangioblastoma, and controls to identify a distinct AVM miRNA signature. AVM smooth muscle cells (AVMSMCs) were isolated and identified by flow cytometry and immunohistochemistry and candidate miRNAs were then tested in these cells...
August 12, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/28799430/genesis-of-an-employee-wellness-program-at-a-large-university
#13
Lisa K Lloyd, Sylvia H Crixell, Janet R Bezner, Katherine Forester, Carolyn Swearingen
University employee wellness programs have potential to support positive changes in employee health, thereby improving productivity and mitigating the rise in health care costs. The purpose of this article is to describe a theory-driven approach to systematically planning, developing, and implementing a comprehensive university employee wellness program. Long-term program goals were to improve employee health, well-being, and productivity by focusing on decreasing sedentary behavior, increasing physical activity, improving dietary habits, and reducing stress...
August 1, 2017: Health Promotion Practice
https://www.readbyqxmd.com/read/28799212/excess-psychosocial-burden-in-women-with-diabetes-and-premature-acute-coronary-syndrome
#14
T M Peters, R Pelletier, H Behlouli, A M Rossi, L Pilote
AIM: Diabetes is a stronger risk factor for acute coronary syndrome for women than men. We investigate whether behavioural and psychosocial factors contribute to the disparity in acute coronary syndrome risk and outcomes among women with diabetes relative to women without diabetes and men. METHODS: Among 939 participants in the GENESIS-PRAXY cohort study of premature acute coronary syndrome (age ≤ 55 years), we compared the prevalence of traditional and non-traditional factors by sex and Type 2 diabetes status...
August 11, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28798990/myocardial-123-i-metaiodobenzylguanidine-imaging-in-hypertension-and-left-ventricular-hypertrophy
#15
Riccardo Liga, Alessia Gimelli, Paolo Marzullo, Giuseppe Ambrosio, Matteo Cameli, Elisabetta Cerbai, Stefano Coiro, Michele Emdin, Rossella Marcucci, Doralisa Morrone, Alberto Palazzuoli, Anna Sonia Petronio, Ketty Savino, Luigi Padeletti, Roberto Pedrinelli
Sympathetic nervous system plays a pivotal role in essential hypertension and in the development of left ventricular hypertrophy. Moreover, cardiac sympathetic dys-regulation has been demonstrated as a key con-causal factor in the genesis and progression of pathologic conditions such as congestive heart failure and ischemic heart disease to which hypertension predisposes as a risk factor. However, despite its fundamental role in cardiac pathophysiology, the evaluation of cardiac sympathetic nervous system has never gained a wide clinical application, remaining mostly a research tool...
August 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28797077/gender-difference-in-nash-susceptibility-roles-of-hepatocyte-ikk%C3%AE-and-sult1e1
#16
Noriko Matsushita, Mohamed T Hassanein, Marcos Martinez-Clemente, Raul Lazaro, Samuel W French, Wen Xie, Keane Lai, Michael Karin, Hidekazu Tsukamoto
Myeloid cell and hepatocyte IKKβ may mediate the genesis of obesity and insulin resistance in mice fed high fat diet. However, their gender-specific roles in the pathogenesis of non-alcoholic steatohepatitis (NASH) are not known. Here we demonstrate myeloid IKKβ deficiency prevents Western diet-induced obesity and visceral adiposity in females but not in males, and attenuates hyperglycemia, global IR, and NASH in both genders. In contrast, all metabolic sequela including NASH are aggravated by hepatocyte IKKβ deficiency (IkbkbΔhep) in male but not female mice...
2017: PloS One
https://www.readbyqxmd.com/read/28796251/differential-spatial-expression-of-peripheral-olfactory-neuron-derived-bace1-induces-olfactory-impairment-by-region-specific-accumulation-of-%C3%AE-amyloid-oligomer
#17
Seung-Jun Yoo, Ji-Hye Lee, So Yeun Kim, Gowoon Son, Jae Yeon Kim, Bongki Cho, Seong-Woon Yu, Keun-A Chang, Yoo-Hun Suh, Cheil Moon
Olfactory dysfunction is a common symptom associated with neurodegenerative diseases including Alzheimer's disease (AD). Although evidence exists to suggest that peripheral olfactory organs are involved in the olfactory dysfunction that accompanies AD pathology, the underlying mechanisms are not fully understood. As confirmed using behavioral tests, transgenic mice overexpressing a Swedish mutant form of human amyloid precursor proteins exhibited olfactory impairments prior to evidence of cognitive impairment...
August 10, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28794080/the-immune-system-in-pediatric-seizures-and-epilepsies
#18
REVIEW
Christian M Korff, Russell C Dale
The relation between the immune system and epilepsy has been studied for a long time. Immune activation may precede or follow the appearance of seizures. Depending on the situation, the innate and acquired immunity may be involved to various degrees. The intense, ongoing research has opened encouraging management and therapeutic perspectives for a significant number of patients suffering from seizures. These include the use of various drugs and less conventional approaches with anti-inflammatory or immunomodulatory properties...
August 9, 2017: Pediatrics
https://www.readbyqxmd.com/read/28789619/high-prevalence-of-co-infection-between-human-papillomavirus-hpv-51-and-52-in-mexican-population
#19
Jazbet Gallegos-Bolaños, Jessica Alejandra Rivera-Domínguez, José Miguel Presno-Bernal, Rodolfo Daniel Cervantes-Villagrana
BACKGROUND: Human papillomavirus (HPV) is associated with the genesis of cervical carcinoma. The co-infection among HPV genotypes is frequent, but the clinical significance is controversial; in Mexico, the prevalence and pattern of co-infection differ depending on the geographic area of study. We analyzed the mono- and co-infection prevalence of multiple HPV genotypes, as well as preferential interactions among them in a Mexico City sample population. METHODS: This study was designed as a retrospective cohort study...
August 8, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28783123/iron-oxidative-damage-and-ferroptosis-in-rhabdomyosarcoma
#20
REVIEW
Alessandro Fanzani, Maura Poli
Recent data have indicated a fundamental role of iron in mediating a non-apoptotic and non-necrotic oxidative form of programmed cell death termed ferroptosis that requires abundant cytosolic free labile iron to promote membrane lipid peroxidation. Different scavenger molecules and detoxifying enzymes, such as glutathione (GSH) and glutathione peroxidase 4 (GPX4), have been shown to overwhelm or exacerbate ferroptosis depending on their expression magnitude. Ferroptosis is emerging as a potential weapon against tumor growth since it has been shown to potentiate cell death in some malignancies...
August 7, 2017: International Journal of Molecular Sciences
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