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Domenico Albano, Giovanni Bosio, Barbara Paghera, Francesco Bertagna
Diagnosing prosthetic joint infection is difficult; clinical signs and symptoms, laboratory tests, radiography, and joint aspiration are less sensitive and specific. We report a patient with fever and painful bilateral hip prosthesis, who underwent Tc-sulesomab scan showing moderate tracer uptake at the lateral surface of the right thigh and no signs of prosthesis infection. The F-FDG-PET/CT showed high uptake at the soft tissue of the right hip prosthesis and detected a fistula. Moreover PET/CT discovered an initial bone marrow involvement at the right femur...
June 2016: Clinical Nuclear Medicine
Alfredo Campennì, Gerardo Caruso, Valeria Barresi, Mariangela Pino, Mariapaola Cucinotta, Sergio Baldari, Maria Caffo
Abscess formation within a brain tumor is uncommon. Intrasellar or parasellar tumors are the most common neoplasms that develop such complications. Cerebral gliomas with abscesses are extremely rare. In this paper three rare cases of glioma associated with abscess formation are described. The diagnosis of brain tumor associated with abscess is particularly difficult by conventional neuroradiological studies. (99m)Tc-labeled sulesomab can be useful in the diagnosis of brain tumors with intratumoral abscesses...
July 2015: Kaohsiung Journal of Medical Sciences
Christopher J Palestro
Radionuclide procedures frequently are performed as part of the diagnostic workup of osteomyelitis. Bone scintigraphy accurately diagnoses osteomyelitis in bones not affected by underlying conditions. Degenerative joint disease, fracture, and orthopedic hardware decrease the specificity of the bone scan, making it less useful in these situations. Gallium-67 scintigraphy was often used as an adjunct to bone scintigraphy for diagnosing osteomyelitis. However, now it is used primarily for spinal infections when (18)F-FDG imaging cannot be performed...
January 2015: Seminars in Nuclear Medicine
Stefan Gratz, Patrik Reize, Bendix Kemke, Wim U Kampen, Markus Luster, Helmut Höffken
BACKGROUND: The aim of this retrospective study was to compare the targeting of "pure" osteomyelitis (i.e., without surrounding soft tissue infection) by directly 99mTc-labelled complete immunoglobulin G (IgG) monoclonal antibody (MAb) ([99mTc]besilesomab) and by directly 99mTc-labelled fragment antigen-binding (FAb) MAb ([99mTc]sulesomab) in relation to their kinetic fate. A total of 73 patients with "pure" osteomyelitis were examined with [99mTc]besilesomab, (Scintimun®, IBA/CIS bio international, Saclay, France; N...
December 2016: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Francesco Galletti, Giovanni Cammaroto, Bruno Galletti, Natale Quartuccio, Francesca Di Mauro, Sergio Baldari
We report two cases of malignant external otitis (MEO) evaluated with Technetium-99m((99m)Tc)-labelled sulesomab. Two patients affected by MEO are presented, together with a literature review. Both patients were studied with clinical examination, ear discharge culture, radiological imaging, blood exams, (99m)Tc Sulesomab, and treated with antibiotic therapy. (99m)Tc-Sulesomab would appear to be an useful tool for diagnosis and follow-up of MEO, highlighting the site and extension of the inflammatory process, and evaluating course and treatment efficacy...
June 2015: European Archives of Oto-rhino-laryngology
Sunita Tarsarya Sonavane, Atul Marwah, Rajnath Jaiswar
Nuclear medicine techniques like (99m)Tc-Leukoscan and (67)Ga-citrate scan have been used in localizing infectious pathologies in renal transplant patients. We present an interesting case of febrile renal transplant with discordant findings of tracer uptake in the transplant kidney on (99m)Tc-Leukoscan and (67)Ga-citrate scan.
October 2011: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
S Gratz, P Reize, A Pfestroff, H Höffken
OBJECTIVE: This prospective study compared the diagnostic accuracy of imaging using an intact murine antigranulocyte antibody 99mTc-besilesomab, and a murine antibody Fab fragment 99mTc-sulesomab, in patients with suspected septically loosened total knee arthroplasty. METHODS: Images from 20 patients who underwent threephase bone scintigraphy followed by imaging using 99mTc-besilesomab (n=10) or 99mTc-sulesomab (n=10) were evaluated and compared. Final diagnosis was determined by microbiological evaluation of aspirated synovial fluid, intraoperative samples through the clinical course, or by long-term follow-up...
2012: Journal of International Medical Research
Raquel Real, Paulo Linhares, Hélder Fernandes, Maria José Rosas, Miguel F Gago, Jorge Pereira, Rui Vaz
Infection constitutes a serious adverse event in patients submitted to deep brain stimulation, often leading to removal of the device. We set to evaluate the potential role of immunoscintigraphy with (99m)Tc-labelled antigranulocyte antibody fragments ((99m)Tc-sulesomab) in the management of infection following DBS. (99m)Tc-sulesomab immunoscintigraphy seems to correlate well with the presence and extent of infection, thus contributing to differentiate between patients who should remove the hardware entirely at presentation and those who could undergo a more conservative approach...
2011: Neurology Research International
Ricardo Sousa, Marta Massada, Alexandre Pereira, Flávia Fontes, Inês Amorim, António Oliveira
OBJECTIVE(S): Autologous-labeled leukocytes combined with sulfur colloid bone marrow scan is the current nuclear medicine gold standard for the diagnosis of prosthetic joint infection. The goal of this study is to assess the diagnostic accuracy of a new nuclear medicine modality for detecting infection in this context. METHODS: Twenty-seven patients with suspicious hip and knee arthroplasties were enrolled prospectively and underwent nuclear medicine testing using 99mTc-sulesomab and 99mTc-nanocolloids sequentially...
September 2011: Nuclear Medicine Communications
Shabina Begum, Ewa Nowosinska, John R Buscombe
Tc-99m sulesomab is indicated in bone and joint infection, but reading of scans can be affected by pre-existing conditions. This case report describes a case of Klippel-Trenaunay syndrome (KTS) which results in vascular malformations of one or more limbs. Tc-99m sulesomab imaging demonstrated persistent blood pool activity up to 20 hours post injection. However, despite this, septic arthritis could be identified with confidence in the same limb.
2010: Nuclear Medicine Review. Central & Eastern Europe
J Meller, T Liersch, M M Oezerden, C O Sahlmann, B Meller
During the last decade considerable effort has been made in the research for in vivo techniques of labeling neutrophils with peptides, labeled cytokines and (99m)Tc-labeled antigranulocyte monoclonal antibodies (AG-Mabs). In general the advantage of in vivo labeling is the simplicity of this approach compared with in vivo techniques. Three of these AG-Mabs have been evaluated in clinical studies: Besilesomab (Scintimun®), Sulesomab (Leucoscan®) and Fanolesomab (Leu-Tech®). White blood cells (WBCs) radiolabeled with AG-Mabs do not show the same behaviour as in vivo labeled white blood cells...
December 2010: Quarterly Journal of Nuclear Medicine and Molecular Imaging
Riccardo Schiavo, Alessandra Ricci, Daniele Pontillo, Giuliana Bernardini, Francesca Fiore Melacrinis, Stefano Maccafeo
We describe a case of implantable cardioverter-defibrillator (ICD) lead infection that was diagnosed by means of sulesomab imaging whereas ultrasound examinations were inconclusive. Nuclear techniques may be helpful in such, not infrequent, settings.
November 2009: Journal of Cardiovascular Medicine
S Gratz, T M Behr, P Reize, A Pfestroff, W U Kampen, H Höffken
The diagnostic accuracy of infection scintigraphy with (99m)Tc-labelled monoclonal antibody Fab' fragments (sulesomab) was studied in patients with suspected total knee arthroplasty (TKA) infection. Images from 26 patients were evaluated by two independent readers and compared with a quantitative interpretation of time-activity courses. Microbiological examinations and joint aspiration results were used as reference standards. Histologically, aseptic TKA loosening occurred in two patients and severe, moderate or mild septic loosening in four, nine and 11 patients, respectively...
January 2009: Journal of International Medical Research
Anne-Marie Quigley, Gopinath Gnanasegaran, John R Buscombe, Andrew J W Hilson
OBJECTIVE: To perform a retrospective review of all patients receiving technetium-99m ((99m)Tc)-labelled sulesomab over a 4-year period to determine if soft tissue infections can be accurately identified. METHODS AND MATERIALS: We reviewed the results of 124 (99m)Tc-sulesomab studies performed over a 4-year period. Of these, 34 were performed for undiagnosed fever in which soft tissue infection was suspected to be the main cause. The patients' clinical notes, microbiology reports and other imaging findings were reviewed to determine the clinical outcome following the scan...
2008: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
E E Pakos, A D Fotopoulos, K S Stafilas, I Gavriilidis, G Al Boukarali, S Tsiouris, T A Xenakis
This study aimed to evaluate the diagnostic efficacy of antigranulocyte scintigraphy using the antibody fragment (99m)Tc-sulesomab (LeukoScan) for the diagnosis of prosthesis infection in patients with total hip or knee arthroplasty. The results from 19 patients with suspected total joint arthroplasty infection who had undergone a three-phase bone scan and a subsequent examination with (99m)Tc-sulesomab during a 1-year period were reviewed. Twelve patients were shown to have prosthesis infection on culture of aspirated synovial fluid or intra-operative samples...
July 2007: Journal of International Medical Research
A Delcourt, D Huglo, T Prangere, H Benticha, F Devemy, D Tsirtsikoulou, M Lepeut, P Fontaine, M Steinling
OBJECTIVES: The diagnosis of osteomyelitis in patients with diabetic foot is difficult both clinically and radiologically. An early diagnosis is crucial to optimize therapeutic strategy. Among the diagnostic methods currently used, scintigraphy with ex-vivo labelled white blood cells is the gold standard, but cannot be performed in all centers; therefore 67Gallium citrate (67Ga) imaging in combination with a bone scintigraphy is still widely used. METHOD: The results of imaging 24 diabetic patients with 31 suspected osteomyelitic lesions using the antigranulocyte Fab' fragment (Sulesomab or LeukoScan or immunoscintigraphy) were prospectively compared with results from the bone scan coupled with 67Ga...
April 2005: Diabetes & Metabolism
Karthikeyan P Iyengar, Sobhan Vinjamuri
BACKGROUND: Investigation of suspected infection in prosthetic joint replacements is a difficult orthopaedic problem with important therapeutic implications. METHODS: We retrospectively analysed the results of 38 patients referred with a clinical suspicion of bone or joint infections. Referrals were made for suspected infection of prosthetic hip joints (17), total knee replacements (13), total elbow replacements (4) and total shoulder replacements (4). Sulesomab imaging was done with 650 MBq of 99mTc Sulesomab...
June 2005: Nuclear Medicine Communications
A Garcia Vicente, M Almoguera, J C Alonso, A Jimenez Heffernan, A Gomez, P I Contreras, J Martin-Comin
OBJECTIVE: The aim of the study was to analyze the use of Tc-99m-labeled antigranulocyte monoclonal antibody fragment Fab'2 (SMab, Leukoscan) in the diagnosis of acute osteomyelitis and articular prosthesis infection. One hundred seventeen patients (118 studies) have been included, 92 women and 25 men. Thirty-seven had a suspicion of osteomyelitis and 81 with suspicion of infection of a hip (35 patients) or a knee (45 patients) prosthesis. The mean age was 64 years. A 3-phase bone scan and a SMab scan were obtained in all patients...
December 2004: Clinical Nuclear Medicine
A Cascio, C Iaria, A Campennì, A Blandino, S Baldari
Twenty-two patients with suspected brucellar spondylitis were investigated to evaluate the possible diagnostic role of Sulesomab, a (99m)Tc-antigranulocyte antibody Fab' fragment. Sensitivity and specificity were compared with those of magnetic resonance imaging (MRI). Skeletal involvement was detected by MRI in 11 cases, while leukoscintigraphy indicated normal vertebral uptake in seven of these patients, increased uptake in two patients, and decreased uptake in two patients. Leukoscintigraphy of the 11 patients negative by MRI demonstrated increased uptake in two cases...
November 2004: Clinical Microbiology and Infection
Anthony M Passalaqua, Robert L Klein, William A Wegener, Joseph A Crawford, John P Crow, David A Andrews, David M Goldenberg
PURPOSE: The aim of this study was to investigate the potential role of a technetium 99m-labeled antigranulocyte murine antibody Fab' fragment (sulesomab) as a diagnostic imaging agent in children with suspected acute nonclassic appendicitis. METHODS: Serial planar images at 15 to 30 minutes, 1, 2, and 4 hours and single-photon emission computed tomography (SPECT) images were acquired after sulesomab injection. In 40 children with suspected acute nonclassic appendicitis, imaging results were confirmed surgically in 21 patients, whereas 19 nonsurgical patients resolved presenting signs and symptoms and were considered to not have appendicitis...
September 2004: Journal of Pediatric Surgery
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