keyword
MENU ▼
Read by QxMD icon Read
search

Anticonvulsant

keyword
https://www.readbyqxmd.com/read/29691835/rufinamide-add-on-therapy-for-refractory-epilepsy
#1
REVIEW
Mariangela Panebianco, Hemanshu Prabhakar, Anthony G Marson
BACKGROUND: Epilepsy is a central nervous system disorder (neurological disorder). Epileptic seizures are the result of excessive and abnormal cortical nerve cell electrical activity in the brain. Despite the development of more than 10 new antiepileptic drugs (AEDs) since the early 2000s, approximately a third of people with epilepsy remain resistant to pharmacotherapy, often requiring treatment with a combination of AEDs. In this review, we summarised the current evidence regarding rufinamide, a novel anticonvulsant medication, which, as a triazole derivative, is structurally unrelated to any other currently used anticonvulsant medication, when used as an add-on treatment for refractory epilepsy...
April 25, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29689077/zebrafish-based-identification-of-the-antiseizure-nucleoside-inosine-from-the-marine-diatom-skeletonema-marinoi
#2
Théo Brillatz, Chiara Lauritano, Maxime Jacmin, Supitcha Khamma, Laurence Marcourt, Davide Righi, Giovanna Romano, Francesco Esposito, Adrianna Ianora, Emerson F Queiroz, Jean-Luc Wolfender, Alexander D Crawford
With the goal of identifying neuroactive secondary metabolites from microalgae, a microscale in vivo zebrafish bioassay for antiseizure activity was used to evaluate bioactivities of the diatom Skeletonema marinoi, which was recently revealed as being a promising source of drug-like small molecules. A freeze-dried culture of S. marinoi was extracted by solvents with increasing polarities (hexane, dichloromethane, methanol and water) and these extracts were screened for anticonvulsant activity using a larval zebrafish epilepsy model with seizures induced by the GABAA antagonist pentylenetetrazole...
2018: PloS One
https://www.readbyqxmd.com/read/29683209/inhibition-of-astroglial-connexin43-hemichannels-with-tat-gap19-exerts-anticonvulsant-effects-in-rodents
#3
Laura Walrave, Anouk Pierre, Giulia Albertini, Najat Aourz, Dimitri De Bundel, Ann Van Eeckhaut, Mathieu Vinken, Christian Giaume, Luc Leybaert, Ilse Smolders
Accumulating evidence shows a key function for astrocytic connexin43 (Cx43) signaling in epilepsy. However, the lack of experimental distinction between Cx43 gap junction channels (GJCs) and hemichannels (HCs) has impeded the identification of the exact contribution of either channel configurations to epilepsy. We therefore investigated whether TAT-Gap19, a Cx mimetic peptide that inhibits Cx43 HCs but not the corresponding Cx43 GJCs, influences experimentally induced seizures in rodents. Dye uptake experiments in acute hippocampal slices of mice demonstrated that astroglial Cx43 HCs open in response to the chemoconvulsant pilocarpine and this was inhibited by TAT-Gap19...
April 23, 2018: Glia
https://www.readbyqxmd.com/read/29681486/novel-naphthyloxy-derivatives-potent-histamine-h-3-receptor-ligands-synthesis-and-pharmacological-evaluation
#4
Dorota Łażewska, Maria Kaleta, Stefanie Hagenow, Szczepan Mogilski, Gniewomir Latacz, Tadeusz Karcz, Annamaria Lubelska, Ewelina Honkisz, Jadwiga Handzlik, David Reiner, Grzegorz Satała, Barbara Filipek, Holger Stark, Katarzyna Kieć-Kononowicz
A series of 1- and 2-naphthyloxy derivatives were synthesized and evaluated for histamine H3 receptor affinity. Most compounds showed high affinities with Ki values below 100 nM. The most potent ligand, 1-(5-(naphthalen-1-yloxy)pentyl)azepane (11) displayed high affinity for the histamine H3 receptor with a Ki value of 21.9 nM. The antagonist behaviour of 11 was confirmed both in vitro in the cAMP assay (IC50  = 312 nM) and in vivo in the rat dipsogenia model (ED50  = 3.68 nM). Moreover, compound 11 showed positive effects on scopolamine induced-memory deficits in mice (at doses of 10 and 15 mg/kg) and an analgesic effect in the formalin test in mice with ED50  = 30...
April 11, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29679069/pharmacological-treatment-of-adult-bipolar-disorder
#5
REVIEW
Ross J Baldessarini, Leonardo Tondo, Gustavo H Vázquez
We summarize evidence supporting contemporary pharmacological treatment of phases of BD, including: mania, depression, and long-term recurrences, emphasizing findings from randomized, controlled trials (RCTs). Effective treatment of acute or dysphoric mania is provided by modern antipsychotics, some anticonvulsants (divalproex and carbamazepine), and lithium salts. Treatment of BD-depression remains unsatisfactory but includes some modern antipsychotics (particularly lurasidone, olanzapine + fluoxetine, and quetiapine) and the anticonvulsant lamotrigine; value and safety of antidepressants remain controversial...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29676839/analgesic-consumption-trajectories-in-8-975-patients-1-year-after-fast-track-total-hip-or-knee-arthroplasty
#6
C C Jørgensen, M Petersen, H Kehlet, E K Aasvang
BACKGROUND: Persistent or increased long-term opioid consumption has previously been described following total hip- (THA) and knee arthroplasty (TKA). However, detailed information on postoperative analgesic consumption trajectories and risk factors associated with continued need of analgesics in fast-track THA and TKA is sparse. METHODS: Descriptive multicenter study in primary unilateral fast-track THA or TKA with prospective data on patient characteristics and information on reimbursement entitled dispensed prescriptions of paracetamol, non-steroidal anti-inflammatory drugs, opioids, anticonvulsants, and antidepressants one month preoperatively and one year postoperatively...
April 20, 2018: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/29673861/il-6-knockout-mice-are-protected-from-cocaine-induced-kindling-behaviors-possible-involvement-of-jak2-stat3-and-pacap-signalings
#7
Huynh Nhu Mai, Yoon Hee Chung, Eun-Joo Shin, Naveen Sharma, Ji Hoon Jeong, Choon-Gon Jang, Kuniaki Saito, Toshitaka Nabeshima, Dora Reglodi, Hyoung-Chun Kim
IL-6 has been recognized as an anticonvulsant against certain neuroexcitotoxicities. We aimed to investigate on the interactive role between IL-6 and PACAP in cocaine-induced kindling behaviors. Although we found that cocaine (45 mg/kg, i.p./day x 5) significantly increased IL-6 and TNF-α expression, it resulted in a decrease in IFN-γ expression. We observed that the cocaine-induced increase in IL-6 expression was more pronounced than that in TNF-α expression. Genetic depletion of IL-6 significantly activated cocaine kindling behaviors...
April 16, 2018: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29673289/systematic-review-of-the-pharmacological-agents-that-have-been-tested-against-spreading-depolarizations
#8
Anna Klass, Renan Sánchez-Porras, Edgar Santos
Spreading depolarization (SD) occurs alongside brain injuries and it can lead to neuronal damage. Therefore, pharmacological modulation of SD can constitute a therapeutic approach to reduce its detrimental effects and to improve the clinical outcome of patients. The major objective of this article was to produce a systematic review of all the drugs that have been tested against SD. Of the substances that have been examined, most have been shown to modulate certain SD characteristics. Only a few have succeeded in significantly inhibiting SD...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29672801/antisuicidal-effects-in-mood-disorders-are-they-unique-to-lithium
#9
Leonardo Tondo, Ross J Baldessarini
INTRODUCTION: Suicidal behavior is strongly associated with depression in major depressive (MDD) and bipolar (BD) disorders, especially with associated behavioral activation, dysphoria, or agitation. A rare intervention with evidence of suicide risk-reducing as well as mood-stabilizing effects in mood disorder patients is lithium. METHODS: We reviewed available research evidence on associations of long-term treatment with lithium with risk of suicidal behavior. We meta-analyzed 12 randomized trials in 10 reports (with at least 1 suicide in either treatment arm) including both BD and MDD subjects, with particular attention to comparisons of lithium with placebo or other pharmacological treatments...
April 19, 2018: Pharmacopsychiatry
https://www.readbyqxmd.com/read/29672474/active-epilepsy-and-seizure-control-in-adults-united-states-2013-and-2015
#10
Niu Tian, Michael Boring, Rosemarie Kobau, Matthew M Zack, Janet B Croft
Approximately 3 million American adults reported active epilepsy* in 2015 (1). Active epilepsy, especially when seizures are uncontrolled, poses substantial burdens because of somatic, neurologic, and mental health comorbidity; cognitive and physical dysfunction; side effects of antiseizure medications; higher injury and mortality rates; poorer quality of life; and increased financial cost (2). Thus, prompt diagnosis and seizure control (i.e., seizure-free in the 12 months preceding the survey) confers numerous clinical and social advantages to persons with active epilepsy...
April 20, 2018: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29665500/aromatase-inhibition-by-letrozole-attenuates-kainic-acid-induced-seizures-but-not-neurotoxicity-in-mice
#11
Ramsha Iqbal, Gaurav K Jain, Fouzia Siraj, Divya Vohora
Evidence shows neurosteroids play a key role in regulating epileptogenesis. Neurosteroids such as testosterone modulate seizure susceptibility through its transformation to metabolites which show proconvulsant and anticonvulsant effects, respectively. Reduction of testosterone by aromatase generates proconvulsant 17-β estradiol. Alternatively, testosterone is metabolized into 5α-dihydrotestosterone (5α-DHT) by 5α-reductase, which is then reduced by 3α-hydroxysteroid oxidoreductase enzyme (3α-HSOR) to form anticonvulsant metabolite 3α-androstanediol (3α-Diol), a potent GABAA receptor modulating neurosteroid...
April 9, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29665379/superparamagnetic-iron-oxide-loaded-lipid-nanocarriers-incorporated-in-thermosensitive-in-situ-gel-for-magnetic-brain-targeting-of-clonazepam
#12
Haidy Abbas, Hanan Refai, Nesrine El Sayed
The objective of the study was to target clonazepam (CZ) to the brain through the intranasal olfactory mucosa using nanolipid carriers loaded with superparamagnetic iron oxide nanoparticles (SPION) to allow nanocarrier guidance and retention with an external magnetic field. For improved delivery the nanolipid carriers were incorporated in a thermosensitive mucoadhesive in situ gel. Different nanolipid carriers including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) were prepared and characterized with respect to particle size, zeta potential, entrapment efficiency and in vitro release...
April 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29665163/lowered-quality-of-life-in-mood-disorders-is-associated-with-increased-neuro-oxidative-stress-and-basal-thyroid-stimulating-hormone-levels-and-use-of-anticonvulsant-mood-stabilizers
#13
Caroline Sampaio Nunes, Michael Maes, Chutima Roomruangwong, Juliana Brum Moraes, Kamila Landucci Bonifacio, Heber Odebrecht Vargas, Decio Sabbatini Barbosa, George Anderson, Luiz Gustavo Piccoli de Melo, Stoyanov Drozdstoj, Estefania Moreira, André F Carvalho, Sandra Odebrecht Vargas Nunes
RATIONALE, AIMS: Major affective disorders including bipolar disorder (BD) and major depressive disorder (MDD) are associated with impaired health-related quality of life (HRQoL). Oxidative stress and subtle thyroid abnormalities may play a pathophysiological role in both disorders. Thus, the current study was performed to examine whether neuro-oxidative biomarkers and thyroid-stimulating hormone (TSH) levels could predict HRQoL in BD and MDD. METHODS: This cross-sectional study enrolled 68 BD and 37 MDD patients and 66 healthy controls...
April 17, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29663484/association-between-psychotropic-medications-and-presence-of-sleep-bruxism-a-systematic-review
#14
REVIEW
Gilberto Melo, Kamile Leonardi Dutra, Rubens Rodrigues Filho, Adriana de Oliveira Lira Ortega, André Luís Porporatti, Bruce Dick, Carlos Flores-Mir, Graziela De Luca Canto
The purpose of this study was to systematically review the literature for studies that investigated the association between use of psychotropic medications and presence of sleep bruxism (SB). Observational studies were selected in a two-phase process. Searches were performed on six electronic databases and a grey literature search was conducted on three databases. SB diagnosis was based on questionnaires or clinical examinations; no polysomnography exams were performed. Risk of bias was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for Analytical Cross-Sectional Studies...
April 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29660115/a-working-model-for-hypothermic-neuroprotection
#15
Guido Wassink, Joanne O Davidson, Christopher A Lear, Sandra E Juul, Frances Northington, Laura Bennet, Alistair J Gunn
Therapeutic hypothermia significantly improves survival without disability in near-term and full-term newborns with moderate-severe hypoxic-ischaemic encephalopathy. However, hypothermic neuroprotection is incomplete. The challenge now is to find ways to further improve outcomes. One major limitation to progress is that the specific mechanisms of hypothermia are only partly understood. Evidence supports the concept that therapeutic cooling suppresses multiple extracellular death signals, including intracellular pathways of apoptotic and necrotic cell death and inappropriate microglial activation...
April 16, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29658840/neuropharmacological-and-molecular-docking-studies-of-xanthones-from-swertia-corymbosa
#16
Ganesan Mahendran, Ramachandran Vijayan
Anxiety represents a public health problem consistently found to be the most prevalent class of mental disorders among people of all ages. Xanthones possess many biological properties, including neuroprotective, antioxidant or antidepressant-like. In this study, we aimed to investigate anxiolytic-like antidepressant and anticonvulsant properties of isolated xanthones from Swertia corymbosa. We evaluated anxiolytic-like activity of compounds 1-3 in the mouse elevated plus maze (EPM) and open field test (OF)...
April 2018: Journal of Receptor and Signal Transduction Research
https://www.readbyqxmd.com/read/29657931/evaluation-of-seizure-frequency-distribution-in-epileptic-patients-with-normal-and-abnormal-electroencephalogram-in-al-zahra-hospital-of-isfahan
#17
Mohmmad Reza Najafi, Rokhsareh Meamar, Nafiseh Karimi
Background: Epilepsy is a chronic neurological disorder characterized by seizure recurrence in patients. Electroencephalogram (EEG) has a diagnostic and prognostic role in the management of patients. Studies have shown a significant relation between seizure recurrence and abnormal EEG in newly diagnosed epileptic patients, and people with first episode of unprovoked seizure. The aim of this study is to evaluate seizure frequency in chronic epileptic patients on drug therapy based on normal or abnormal EEG...
2018: Advanced Biomedical Research
https://www.readbyqxmd.com/read/29653413/influence-of-propafenone-on-the-anticonvulsant-activity-of-various-novel-antiepileptic-drugs-in-the-mouse-maximal-electroshock-model
#18
Kinga K Borowicz-Reutt, Monika Popławska, Monika Banach, Dorota Wróblewska
BACKGROUND: The main mechanism of action of propafenone (antiarrhythmic drug) involves the inhibition of the fast inward sodium current during phase 0 of the action potential. Sodium channel-blocking activity is also characteristic for some antiepileptic drugs. Therefore, it could be assumed that propafenone may also affect seizures. In the present study, we evaluated the effect of propafenone on the protective effect of oxcarbazepine, lamotrigine, topiramate and pregabalin against the maximal electroshock-induced seizures in mice...
November 23, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29650996/embryonic-exposure-to-valproic-acid-impairs-social-predispositions-of-newly-hatched-chicks
#19
Paola Sgadò, Orsola Rosa-Salva, Elisabetta Versace, Giorgio Vallortigara
Biological predispositions to attend to visual cues, such as those associated with face-like stimuli or with biological motion, guide social behavior from the first moments of life and have been documented in human neonates, infant monkeys and domestic chicks. Impairments of social predispositions have been recently reported in neonates at high familial risk of Autism Spectrum Disorder (ASD). Using embryonic exposure to valproic acid (VPA), an anticonvulsant associated to increased risk of developing ASD, we modeled ASD behavioral deficits in domestic chicks...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29650833/-a-case-of-local-recurrence-of-descending-colon-cancer-with-ileus-obstruction-and-lung-liver-and-brain-metastasis
#20
Ryouichi Tomita, Shigeru Fujisaki, Kenichi Sakurai, Takeo Azuhata, Yuko Takamoto
We report a 50-year-old man with local recurrence of descending colon cancer with ileus obstruction and brain metastasis, 2 years 6 months after initial resection due to perforation of descending colon cancer(Hartmann procedure, D2 lymph node resection, Stage II, tub2). He complained of left upper abdominal pain and abdominal fullness. He also complained of paresis of the right upper extremity and of experiencing convulsions 1 month before admission. He was diagnosed with local recurrence of descending colon cancer, based on findings of contrast radiography and the presence of colonic fiber...
April 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
keyword
keyword
28265
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"