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https://www.readbyqxmd.com/read/29451101/severe-tricuspid-regurgitation-and-seizure-on-postpartum-day-10-case-report-of-late-postpartum-eclampsia
#1
Martin Vanden Eede, Matthew Schroyens
OBJECTIVE AND IMPORTANCE: Late postpartum eclampsia is characterized by pre-eclampsia and tonic-clonic seizures presenting more than 48 hours postpartum. It is a rare, frightening and dangerous complication that requires rapid recognition and adequate treatment. CLINICAL PRESENTATION: We present a case of late postpartum eclampsia, initially diagnosed as right-sided heart failure, 10 days postpartum.Two days after the delivery she developed mild swelling of both feet, progressive shortness of breath on exertion and orthopnea...
February 16, 2018: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29449212/cannabis-as-an-anticonvulsant
#2
(no author information available yet)
No abstract text is available yet for this article.
February 15, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29447051/targeting-crosstalk-between-nuclear-factor-erythroid-derived-2-like-2-and-nuclear-factor-kappa-beta-pathway-by-nrf2-activator-dimethyl-fumarate-in-epileptogenesis
#3
Neha Singh, Sheekha Vijayanti, Lekha Saha
Epilepsy is a complex, chronic neurological disorder characterized by increased and abnormal synchronization of neuronal electrical activity, which is manifested as seizures. It is associated with many comorbid conditions such as depression, anxiety, sleep disorder, psychiatric disorder etc. which consequently causes higher mortality rate. The understanding of its cellular and molecular mechanism is partial, because of which it remains an ongoing health problem, despite the increasing availability of newer antiepileptic drugs...
February 15, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29445628/medicinal-properties-of-adiantum-capillus-veneris-linn-in-traditional-medicine-and-modern-phytotherapy-a-review-article
#4
REVIEW
Sahar Dehdari, Homa Hajimehdipoor
Background: Adiantum capillus-veneris Linn (Maidenhair fern) is an herb belonging to the family Pteridaceae. It is named as " Pare-siavashan " in medical and pharmaceutical textbooks of Iranian Traditional Medicine. The fronds of Maidenhair fern were mainly administrated by ancient physicians as single medicine or in combination with other plants in multi-herbal formulations for curing different diseases. Because of different chemical compositions, the herb fronds were also assessed for its numerous pharmacological effects...
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29441712/effectiveness-of-maintenance-therapy-of-lithium-vs-other-mood-stabilizers-in-monotherapy-and-in-combinations-a-systematic-review-of-evidence-from-observational-studies
#5
REVIEW
Lars Vedel Kessing, Michael Bauer, Willem A Nolen, Emanuel Severus, Guy M Goodwin, John Geddes
OBJECTIVES: For the first time to present a systematic review of observational studies on the efficiency of lithium monotherapy in comparison with other maintenance mood stabilizers in monotherapy and in combination. METHODS: As part of the International Society for Bipolar Disorders (ISBD) Task Force on Lithium Treatment, we undertook a systematic literature search of non-randomized controlled observational studies on (i) lithium monotherapy vs treatment with another maintenance mood stabilizer in monotherapy and (ii) lithium in combination with other mood stabilizers vs monotherapy...
February 14, 2018: Bipolar Disorders
https://www.readbyqxmd.com/read/29438649/cannabis-for-paediatric-epilepsy-challenges-and-conundrums
#6
Kerrie-Anne Chen, Michelle A Farrar, Michael Cardamone, John A Lawson
Research is expanding for the use of cannabidiol as an anticonvulsant drug. The mechanism of cannabidiol in paediatric epilepsy is unclear but is thought to play a role in modulation of synaptic transmission. Evidence for its efficacy in treating epilepsy is limited but growing, with a single pharmaceutical company-funded randomised double-blind controlled trial in children with Dravet syndrome. Progress towards the use of medicinal cannabinoids incorporates a complex interplay of social influences and political and legal reform...
February 19, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/29437013/topiramate-induced-limbs-paraesthesia-and-rigid-fingers-flexion
#7
Andrea Domenico Pratico, Martino Ruggieri, Raffaele Falsaperla, Piero Pavone
Topiramate is a well-known anticonvulsant drug with a broad spectrum of actions. It has been proposed in the treatment of several types of epileptic seizures both in monotherapy and in add-on. Its usage has been extended to other disorders including migraine, essential tremor, obesity, alcohol and drug addiction. The most frequent side-effects of topiramate include dizziness, somnolence, insomnia, and ataxia. Paraesthesia, metabolic acidosis, kidney stones, hypohidrosis, cognitive impairment and eye symptoms have been also reported...
February 12, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/29436790/cromakalim-a-potassium-channel-opener-ameliorates-the-organophosphate-and-carbamate-induced-seizure-in-mice
#8
Sattar Ostadhadi, Abouzar Moradi, Samira Zolfaghari, Vahid Nikoui, Ahmad Reza Dehpour
Organophosphates (OPs) and carbamates are acetylcholine esterase inhibitors (AChEIs), which can cause seizure and lethality. Anticonvulsant properties of potassium channel openers including cromakalim have been determined in previous studies. In the present experiment, the possible effect of cromakalim on the convulsion and death induced by OPs and carbamates was studied in mice. Dichlorvos (an OP, 50 mg/kg) and physostigmine (a carbamate, 2 mg/kg) were used to induce seizure in animals. Cromakalim at doses of 0...
January 2018: Acta Medica Iranica
https://www.readbyqxmd.com/read/29433669/behavioral-and-electroencephalographic-evaluation-of-the-anticonvulsive-activity-of-moringa-oleifera-leaf-non-polar-extracts-and-one-metabolite-in-ptz-induced-seizures
#9
María Eva González-Trujano, Claudia Lizbeth Martínez-González, Maricela Flores-Carrillo, Sara Ibeth Luna-Nophal, Gerardo Contreras-Murillo, Víctor Manuel Magdaleno-Madrigal
BACKGORUND: Moringa oleifera Lamarck is a species that has long been used in high demand in folk medicine, including for the treatment of epilepsy. Nevertheless, scientific studies demonstrating its anticonvulsant properties and the nature of the bioactive constituents are lacking. HYPOTHESIS/AIM: The aim of this study was to evaluate the anticonvulsant activities of the Moringa oleifera leaves in non-polar vs. polar extracts using behavioral and electroencephalographic (EEG) analyses in rodents...
January 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29433418/evaluation-of-the-utility-of-a-dietary-therapy-second-opinion-clinic
#10
Angelica R Lackey, Zahava Turner, Courtney A Haney, Anthony C Stanfield, Eric H Kossoff
Fine-tuning ketogenic diets to achieve better seizure control may influence families to seek second opinions. Since 2009, Johns Hopkins Hospital has provided second opinions for children followed at other ketogenic diet centers. We retrospectively reviewed 65 consecutive children seen in this clinic; parents were also sent a 2-page survey. The mean age was 6.6 years and dietary therapy had been used a median 9 months. Seizure reduction >50% was achieved in 65%, including 35% with >90% reduction. Parent questions included how to improve seizure control (65%), ideal diet duration (18%), and confirmation of the plan (11%)...
March 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29433220/coriander-coriandrum-sativum-a-promising-functional-food-toward-the-well-being
#11
REVIEW
Veda Prachayasittikul, Supaluk Prachayasittikul, Somsak Ruchirawat, Virapong Prachayasittikul
Coriandrum sativum (C. sativum) or coriander is one of the most popularly used spices in culinary worldwide, and its medicinal values has been recognized since ancient time. C. sativum contains bioactive phytochemicals that are accounted for a wide range of biological activities including antioxidant, anticancer, neuroprotective, anxiolytic, anticonvulsant, analgesic, migraine-relieving, hypolipidemic, hypoglycemic, hypotensive, antimicrobial, and antiinflammatory activities. The major compound, linalool, abundantly found in seeds is remarked for its abilities to modulate many key pathogenesis pathways of diseases...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29427870/the-use-of-prescription-medication-in-239-patients-with-multiple-functional-somatic-syndromes
#12
Johanne L Agger, Per K Fink, Lise K Gormsen, Jens S Jensen, Andreas Schröder
OBJECTIVE: To describe the use of prescription drugs and their association with patient characteristics in patients with multiple functional somatic syndromes (FSS) focusing on drugs generally recommended and not recommended in FSS treatment. METHOD: Using data from a national prescription registry, we describe the drug use during a two-year period for 239 trial participants. Using regression models, we analyse the associations of patient characteristics with the patterns of use of antidepressants, anticonvulsants, opioids and sedatives...
February 2, 2018: General Hospital Psychiatry
https://www.readbyqxmd.com/read/29427835/phenytoin-related-ataxia-in-patients-with-epilepsy-clinical-and-radiological-characteristics
#13
Priya D Shanmugarajah, Nigel Hoggard, Daniel P Aeschlimann, Pascale C Aeschlimann, Gary J Dennis, Stephen J Howell, Markus Reuber, Richard A Grünewald, Marios Hadjivassiliou
PURPOSE: Phenytoin is an effective anticonvulsant for focal epilepsy. Its use can be associated with long-term adverse effects including cerebellar ataxia. Whilst phenytoin is toxic to Purkinje cells in vitro; the clinical and radiological phenotype and mechanism of cerebellar degeneration in vivo remain unclear. We describe the prevalence, clinical and radiological characteristics of phenytoin-related ataxia. METHODS: Patients with epilepsy receiving treatment with phenytoin were recruited from the Epilepsy clinics at Royal Hallamshire Hospital, Sheffield, UK...
February 2, 2018: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29427285/effect-of-tadalafil-on-seizure-threshold-and-activity-of-antiepileptic-drugs-in-three-acute-seizure-tests-in-mice
#14
Katarzyna Socała, Dorota Nieoczym, Mateusz Pieróg, Elżbieta Wyska, Małgorzata Szafarz, Urszula Doboszewska, Piotr Wlaź
Tadalafil, a selective phosphodiesterase type 5 inhibitor, is a long-acting oral agent for the treatment of erectile dysfunction of multiple etiologies. Although generalized tonic-clonic seizures were reported in a healthy man after taking tadalafil, the influence of tadalafil on seizure susceptibility has not been studied so far. Therefore, the aim of the present study was to investigate the effect of tadalafil on seizure threshold as well as on the activity of some first- and second-generation antiepileptic drugs in three acute seizure tests in mice...
February 9, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29425699/evaluating-the-use-of-medicare-part-d-in-the-spinal-cord-injury-disorder-veteran-population
#15
Maya N Hatch, Jason Raad, Katie Suda, Kevin T Stroupe, Alice J Hon, Bridget M Smith
OBJECTIVE: To examine the different sources of medications, the most common drugs classes filled, and the characteristics associated with Medicare Part D pharmacy use in Veterans with spinal cord injuries/disorders (SCI/D). DESIGN: This was a retrospective, cross-sectional observation study. SETTING: Department of Veterans Affairs (VA) PARTICIPANTS: Veterans with SCI/D using Medicare or Veteran Affairs Pharmacy benefits. INTERVENTIONS: None MAIN OUTCOME MEASURE(S): Characteristics and top 10 most common drug classes were examined in Veterans who (1) used VA pharmacies only, (2) dually used VA and Part D pharmacies, or (3) Part D pharmacies only...
February 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29425063/psychotropic-medication-patterns-for-american-indian-children-in-foster-care
#16
David Glesener, Gwendolyn Anderson, Xuan Li, Jacob Brown, James Amell, Ronald Regal, Donald Ferguson
OBJECTIVE: This study assesses the effects of race, age, sex, and time spent in foster care on rates of psychotropic medication use for children in foster care in 2012. METHODS: Using existing electronic records through county Social Service and Minnesota Medical Assistance databases, 626 children were identified using the inclusion criteria of having been in foster care for at least 30 days during 2012 in St. Louis County, Minnesota. All prescriptions for dispensed psychotropic medications were identified into the following classes: antidepressants, attention-deficit/hyperactivity disorder (ADHD) medications, antipsychotics, alpha-agonists, and other (including anticonvulsants/mood stabilizers, lithium, benzodiazepines, and sedative hypnotics)...
February 9, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29422395/diurnal-occurrence-of-complex-febrile-seizure-and-their-severity-in-pediatric-patients-needing-hospitalization
#17
Hiroshi Yamaguchi, Hiroaki Nagase, Yusuke Ishida, Daisaku Toyoshima, Azusa Maruyama, Kazumi Tomioka, Tsukasa Tanaka, Masahiro Nishiyama, Kyoko Fujita, Taniguchi-Ikeda Mariko, Kandai Nozu, Ichiro Morioka, Noriyuki Nishimura, Hiroshi Kurosawa, Satoshi Takada, Yoshiyuki Uetani, Kazumoto Iijima
Several studies describing the diurnal occurrence of febrile seizures have reported greater seizure frequency early or late in the evening relative to midnight or early morning. However, no articles have reported on the diurnal occurrence of complex febrile seizure. Moreover, no studies have addressed the relationship between seizure severity and diurnal occurrence. We retrospectively evaluated complex febrile seizures in 462 children needing hospitalization, and investigated the relationship between severity and diurnal occurrence according to four categorized time periods (morning, afternoon, evening, and night)...
February 5, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29417472/gastrodin-suppresses-pentylenetetrazole-induced-seizures-progression-by-modulating-oxidative-stress-in-zebrafish
#18
Meng Jin, Qiuxia He, Shanshan Zhang, Yixuan Cui, Liwen Han, Kechun Liu
Pentylenetetrazole (PTZ)-induced seizures in Zebrafish models are now widely accepted for investigating human disease epilepsy. In epilepsy, the generation of oxidative stress contributes to the brain injury. Although Gastrodin (GAS) has been reported to have anticonvulsant activities, its effects on zebrafish seizure models and the underlying mechanism remain unclear. In this study, we evaluated the effects of GAS pretreatment on PTZ-induced seizures in zebrafish larvae and investigated the underlying mechanism related to its anti-oxidative defense...
February 7, 2018: Neurochemical Research
https://www.readbyqxmd.com/read/29417440/caffeine-protects-against-anticonvulsant-induced-impaired-neurogenesis-in-the-developing-rat-brain
#19
Stefanie Endesfelder, Ulrike Weichelt, Cornelia Schiller, Katja Winter, Clarissa von Haefen, Christoph Bührer
In preterm infants, phenobarbital is the first-line antiepileptic drug for neonatal seizures while caffeine is used for the treatment of apnea. Data from experimental animals suggest that phenobarbital and other anticonvulsants are toxic for the developing brain, while neuroprotective effects have been reported for caffeine both in newborn rodents and preterm human infants. To characterize the interaction of phenobarbital and caffeine in the hippocampus of the developing rodent brain, we examined the effects of both drugs given separately or together on postnatal neurogenesis after administration to neonatal rats throughout postnatal day (P) 4 to P6...
February 7, 2018: Neurotoxicity Research
https://www.readbyqxmd.com/read/29417081/pharmacokinetic-behavior-of-phenytoin-in-head-trauma-and-cerebrovascular-accident-patients-in-an-iranian-population
#20
Shahnaz Alimardani, Sima Sadrai, Hamidreza Taghvaye Masoumi, Pooneh Salari, Atabak Najafi, Behzad Eftekhar, Mojtaba Mojtahedzadeh
Objective: Acute brain injury is one of the leading causes of morbidity and mortality worldwide. Phenytoin has been commonly used as an anticonvulsant agent for the treatment or prophylaxis of seizures following acute brain injury. After a severe head injury, several pharmacokinetic changes occur. The aim of this study is the comparative evaluation of phenytoin serum concentration in patients with traumatic and nontraumatic brain injury (TBI). Methods: This prospective observational study was performed on twenty adult brain injury patients who were admitted to an Intensive Care Unit and required phenytoin for the treatment or prophylaxis of postinjury seizures...
October 2017: Journal of Research in Pharmacy Practice
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