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https://www.readbyqxmd.com/read/28093303/chlorogenic-acid-rescues-sensorineural-auditory-function-in-a-diabetic-animal-model
#1
Bin Na Hong, Youn Hee Nam, Sang Ho Woo, Tong Ho Kang
Recently, many studies have reported that sensorineural hearing impairment related to neurological disorders may be caused by diabetes mellitus. However, to date, only a small number of studies have investigated the treatment of sensorineural hearing impairment. In the present study, the effects of chlorogenic acid on diabetic auditory pathway impairment were evaluated by neuro-electrical physiological measurements and morphological investigations. We have shown that CA efficiently prevents the progression of auditory pathway dysfunction caused by DM using auditory brainstem responses and auditory middle latency responses in mice...
January 13, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28039682/citicoline-for-traumatic-brain-injury-a-systematic-review-meta-analysis
#2
Ali Meshkini, Mohammad Meshkini, Homayoun Sadeghi-Bazargani
BACKGROUND: Traumatic Brain Injury (TBI) is the leading cause of mortality and morbidity especially in young ages. Despite over 30 years of using Neuroprotective agents for TBI management, there is no absolute recommended agent for the condition yet. METHODS: This study is a part of a scoping review thesis on "Neuroprotective agents using for Traumatic Brain Injury: a systematic review & meta-analyses", which had a wide proposal keywords and ran in "Cochrane CENTRAL", "MedLine/PubMed", "SCOPUS", "Thomson Reuters Web of Science", "SID...
January 1, 2017: Journal of Injury & Violence Research
https://www.readbyqxmd.com/read/27928386/current-perspectives-of-bioptic-driving-in-low-vision
#3
REVIEW
Robert Chun, Maria Cucuras, Walter M Jay
In this review, the authors discuss the current perspectives of spectacle-mounted telescopes (bioptics) used for driving among patients with vision impairments. The history, design, driving laws surrounding bioptic use, and developing programs in The Netherlands and Canada are discussed. Patients who have certain visual requirements and stable disease status may be eligible candidates to consider using a bioptic aid for driving. Given the high prevalence of depression among visually impaired patients, low vision specialists can work with neuro-ophthalmologists to maximise the independence and visual function of patients who have permanent vision impairments but capable of maintaining driving privileges...
April 2016: Neuro-ophthalmology
https://www.readbyqxmd.com/read/27805786/neurotensin-conjugated-reduced-graphene-oxide-with-multi-stage-near-infrared-triggered-synergic-targeted-neuron-gene-transfection-in-vitro-and-in-vivo-for-neurodegenerative-disease-therapy
#4
Tsung-Ying Hsieh, Wei-Chen Huang, Yi-Da Kang, Chao-Yi Chu, Wen-Lin Liao, You-Yin Chen, San-Yuan Chen
Delivery efficiency with gene transfection is a pivotal point in achieving maximized therapeutic efficacy and has been an important challenge with central nervous system (CNS) diseases. In this study, neurotensin (NT, a neuro-specific peptide)-conjugated polyethylenimine (PEI)-modified reduced graphene oxide (rGO) nanoparticles with precisely controlled two-stage near-infrared (NIR)-laser photothermal treatment to enhance the ability to target neurons and achieve high gene transfection in neurons. First-stage NIR laser irradiation on the cells with nanoparticles attached on the surface can increase the permeability of the cell membrane, resulting in an apparent increase in cellular uptake compared to untreated cells...
December 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27789117/acute-ataxia-in-children-a-review-of-the-differential-diagnosis-and-evaluation-in-the-emergency-department
#5
REVIEW
Mauro Caffarelli, Amir A Kimia, Alcy R Torres
Acute ataxia in a pediatric patient poses a diagnostic dilemma for any physician. While the most common etiologies are benign, occasional individuals require urgent intervention. Children with stroke, toxic ingestion, infection, and neuro-inflammatory disorders frequently exhibit ataxia as an essential-if not the only-presenting feature. The available retrospective research utilize inconsistent definitions of acute ataxia, precluding the ability to pool data from these studies. No prospective data exist that report on patients presenting to the emergency department with ataxia...
December 2016: Pediatric Neurology
https://www.readbyqxmd.com/read/27759956/a-positive-correlation-exists-between-neurotrauma-and-tgf-%C3%AE-1-containing-microglia-in-rats
#6
Chung-Ching Chio, Mao-Tsun Lin, Ching-Ping Chang, Hung-Jung Lin
BACKGROUND: Transforming growth factor-beta 1 (TGF-β1) regulates many processes after traumatic brain injury (TBI). Both Neuro AiD™ (MLC601) and astragaloside (AST) attenuate microglia activation in rats with TBI. The purpose of this study was to investigate whether MLC601 or AST improves output of TBI by affecting microglial expression of TGF-β1. MATERIALS AND METHODS: Adult male Sprague-Dawley rats (120 in number) were used to investigate the contribution of TGF-β1-containing microglia in the MLC601-mediated or the AST-mediated neuroprotection in the brain trauma condition using lateral fluid percussion injury...
December 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27737697/loss-of-cerebellar-neurons-in-the-progression-of-lentiviral-disease-effects-of-cns-permeant-antiretroviral-therapy
#7
Christian Wächter, Lee E Eiden, Nedye Naumann, Candan Depboylu, Eberhard Weihe
BACKGROUND: The majority of investigations on HIV-associated neurocognitive disorders (HAND) neglect the cerebellum in spite of emerging evidence for its role in higher cognitive functions and dysfunctions in common neurodegenerative diseases. METHODS: We systematically investigated the molecular and cellular responses of the cerebellum as contributors to lentiviral infection-induced neurodegeneration, in the simian immunodeficiency virus (SIV)-infected rhesus macaque model for HIV infection and HAND...
October 14, 2016: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/27705817/peptidomics-of-the-zebrafish-danio-rerio-in-search-for-neuropeptides
#8
Kristien A Van Camp, Geert Baggerman, Ronny Blust, Steven J Husson
: (Neuro)peptides are small messenger molecules that are derived from larger, inactive precursor proteins by the highly controlled action of processing enzymes. These biologically active peptides can be found in all metazoan species where they orchestrate a wide variety of physiological processes. Obviously, detailed knowledge on the actual peptide sequences, including the potential existence of truncated versions or presence of post-translation modifications, is of high importance when studying their function...
October 2, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/27683300/catamnesis-results-of-an-inpatient-neuro-otologic-and-psychosomatic-tinnitus-therapy-1-5-years-after-discharge
#9
H Schaaf, S Weiß, G Hesse
Treating tinnitus with the resources offered in hospitals can become necessary for patients suffering from complex tinnitus if a high symptom severity, usually accompanied by a corresponding psychosomatic comorbidity, is present. For such costly therapies, for example, the neuro-otologic psychosomatic tinnitus therapy (NPT) examined here, the long-term effect is particularly important; however, reliable catamnesis studies for inpatient treatments are not yet available. Data from 169 (from a total of 327 contacted) inpatients suffering from complex tinnitus were analysed here...
September 28, 2016: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/27659543/non-invasive-detection-of-2-hydroxyglutarate-in-idh-mutated-gliomas-using-two-dimensional-localized-correlation-spectroscopy-2d-l-cosy-at-7-tesla
#10
Gaurav Verma, Suyash Mohan, MacLean P Nasrallah, Steven Brem, John Y K Lee, Sanjeev Chawla, Sumei Wang, Rajakumar Nagarajan, M Albert Thomas, Harish Poptani
BACKGROUND: Mutations in the isocitrate dehydrogenase enzyme are present in a majority of lower-grade gliomas and secondary glioblastomas. This mis-sense mutation results in the neomorphic reduction of isocitrate dehydrogenase resulting in an accumulation of the "oncometabolite" 2-hydroxyglutarate (2HG). Detection of 2HG can thus serve as a surrogate biomarker for these mutations, with significant translational implications including improved prognostication. Two dimensional localized correlated spectroscopy (2D L-COSY) at 7T is a highly-sensitive non-invasive technique for assessing brain metabolism...
September 22, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27534317/developing-a-user-centred-planning-tool-for-young-adults-with-development-disorders-a-research-based-teaching-project
#11
Kirsten Ribu, Tulpesh Patel
People with development disorders, for instance autism, need structured plans to help create predictability in their daily lives. Digital plans can facilitate enhanced independency, learning, and quality of life, but existing apps are largely general purpose and lack the flexibility required by this specific but heterogeneous user group. Universal design is both a goal and a process and should be based on a holistic approach and user-centered design, interacting with the users in all stages of the development process...
2016: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/27487266/network-ethnopharmacological-evaluation-of-the-immunomodulatory-activity-of-withania-somnifera
#12
Uma Chandran, Bhushan Patwardhan
ETHNOPHARMACOLOGICAL RELEVANCE: Withania somnifera (L.) Dunal (Ashwagandha, WS) is one of the extensively explored Ayurvedic botanicals. Several properties including immunomodulation, anti-cancer and neuro-protection of the botanical have been reported. Even though, in indigenous medicine, WS is well known for its immunomodulatory activity, the molecular mechanism of immunomodulation has not been elucidated. AIM OF THE STUDY: This study aimed the evaluation of the immunomodulatory effect of WS using network ethnopharmacology technique to elucidate the in silico molecular mechanism...
July 31, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27459844/analysis-of-reaching-movements-of-upper-arm-in-robot-assisted-exercises-kinematic-assessment-of-robot-assisted-upper-arm-reaching-single-joint-movements
#13
Luigi Iuppariello, Giovanni D'Addio, Maria Romano, Paolo Bifulco, Bernardo Lanzillo, Nicola Pappone, Mario Cesarelli
Robot-mediated therapy (RMT) has been a very dynamic area of research in recent years. Robotics devices are in fact capable to quantify the performances of a rehabilitation task in treatments of several disorders of the arm and the shoulder of various central and peripheral etiology. Different systems for robot-aided neuro-rehabilitation are available for upper limb rehabilitation but the biomechanical parameters proposed until today, to evaluate the quality of the movement, are related to the specific robot used and to the type of exercise performed...
April 2016: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/27412789/dopaminergic-receptor-blockade-changes-a-functional-connectivity-network-centred-on-the-amygdala
#14
Jan Haaker, Mareike M Menz, Tahmine Fadai, Falk Eippert, Christian Büchel
Resting-state connectivity has become an increasingly important measure in characterizing the functional integrity of brain circuits in neuro-psychiatric conditions. One approach that has recently gained prominence in this regard-and which we use in this study-is to investigate how resting-state connectivity depends on the integrity of certain neuromodulator systems. Here, we use a pharmacological challenge in combination with functional magnetic resonance imaging to investigate the impact of dopaminergic receptor blockade on whole brain functional connectivity in twenty healthy human subjects...
November 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27392339/eeg-informed-attended-speaker-extraction-from-recorded-speech-mixtures-with-application-in-neuro-steered-hearing-prostheses
#15
Simon Van Eyndhoven, Tom Francart, Alexander Bertrand
OBJECTIVE: We aim to extract and denoise the attended speaker in a noisy, two-speaker acoustic scenario, relying on microphone array recordings from a binaural hearing aid, which are complemented with electroencephalography (EEG) recordings to infer the speaker of interest. METHODS: In this study, we propose a modular processing flow that first extracts the two speech envelopes from the microphone recordings, then selects the attended speech envelope based on the EEG, and finally uses this envelope to inform a multi-channel speech separation and denoising algorithm...
July 7, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27375173/pedidbs-the-pediatric-international-deep-brain-stimulation-registry-project
#16
Warren Marks, Laurie Bailey, Terence D Sanger
BACKGROUND: Interactive neuromodulation represents the evolving frontier in surgical treatment of a variety of disorders involving the sensory organs and nervous system. Building on the advances of pioneering neurologists and neurosurgeons, progress has been made since the introduction of deep brain stimulation (DBS). Microelectrode recording has greatly aided our understanding of the underlying pathogenesis of movement disorders and the effects of electrical stimulation. The introduction of image - guided systems to provide targeted, controlled neuro-stimulation to specific brain areas is an emerging technique for implantation and may have special appeal for pediatric patients...
June 18, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27349234/-standard-operating-procedures-sops-for-palliative-care-presence-and-relevance-of-palliative-sops-within-the-network-of-german-comprehensive-cancer-centers-cccs-funded-by-the-german-cancer-aid
#17
P Stachura, J Berendt, S Stiel, U S Schuler, C Ostgathe
BACKGROUND: Standard operating procedures (SOPs) can contribute to the improvement of patient care. OBJECTIVES: Survey the presence and relevance of SOPs for palliative care (PC) within the network of German Comprehensive Cancer Centers (CCCs) funded by the German Cancer Aid. MATERIALS AND METHODS: In a descriptive survey, palliative care services within 15 CCCs funded by the German Cancer Aid were asked to rate availability and thematic relevance of (1) symptom-related, (2) clinical pathways and (3) measures- and processes-oriented SOPs using a structured questionnaire...
June 27, 2016: Der Schmerz
https://www.readbyqxmd.com/read/27348750/neuromyelitis-optica-spectrum-disorder-disease-course-and-long-term-visual-outcome
#18
Judith Brody, Mark A Hellmann, Romain Marignier, Itay Lotan, Hadas Stiebel-Kalish
BACKGROUND: Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune disease that classically manifests as attacks of optic neuritis (ON) and transverse myelitis (TM). The prevalence, course, and severity of NMOSD vary considerably. Few studies report the neuro-ophthalmologic disease course and visual outcome. OBJECTIVE: We sought to describe the course and long-term visual outcome in a cohort of NMOSD patients treated in a single tertiary referral center...
December 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/27329646/a-2-substituted-8-hydroxyquinoline-stimulates-neural-stem-cell-proliferation-by-modulating-ros-signalling
#19
Cathryn L Haigh, Carolin Tumpach, Steven J Collins, Simon C Drew
Eight-hydroxyquinolines (8HQs) are a class of compounds that have been identified as potential therapeutics for a number of neurodegenerative diseases. Understanding the influence of structural modifications to the 8HQ scaffold on cellular behaviour will aid the identification of compounds that might be effective in treating dementias. In this study, we describe the action of 2-[(dimethylamino)methyl]-8-hydroxyquinoline (DMAMQ) on adult murine neural stem cells (NSCs) cultured in vitro. Treatment of NSCs with DMAMQ resulted in enhanced self-renewal and increased neurite outgrowth...
September 2016: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/27220881/simultaneous-multislice-magnetic-resonance-fingerprinting-sms-mrf-with-direct-spiral-slice-grappa-ds-sg-reconstruction
#20
Huihui Ye, Stephen F Cauley, Borjan Gagoski, Berkin Bilgic, Dan Ma, Yun Jiang, Yiping P Du, Mark A Griswold, Lawrence L Wald, Kawin Setsompop
PURPOSE: To develop a reconstruction method to improve SMS-MRF, in which slice acceleration is used in conjunction with highly undersampled in-plane acceleration to speed up MRF acquisition. METHODS: In this work two methods are employed to efficiently perform the simultaneous multislice magnetic resonance fingerprinting (SMS-MRF) data acquisition and the direct-spiral slice-GRAPPA (ds-SG) reconstruction. First, the lengthy training data acquisition is shortened by employing the through-time/through-k-space approach, in which similar k-space locations within and across spiral interleaves are grouped and are associated with a single set of kernel...
May 25, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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