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https://www.readbyqxmd.com/read/29793134/voxel-based-automated-detection-of-focal-cortical-dysplasia-lesions-using-diffusion-tensor-imaging-and-t2-weighted-mri-data
#1
Yanming Wang, Yawen Zhou, Huijuan Wang, Jin Cui, Benedictor Alexander Nguchu, Xufei Zhang, Bensheng Qiu, Xiaoxiao Wang, Mingwang Zhu
The aim of this study was to automatically detect focal cortical dysplasia (FCD) lesions in patients with extratemporal lobe epilepsy by relying on diffusion tensor imaging (DTI) and T2-weighted magnetic resonance imaging (MRI) data. We implemented an automated classifier using voxel-based multimodal features to identify gray and white matter abnormalities of FCD in patient cohorts. In addition to the commonly used T2-weighted image intensity feature, DTI-based features were also utilized. A Gaussian processes for machine learning (GPML) classifier was tested on 12 patients with FCD (8 with histologically confirmed FCD) scanned at 1...
May 21, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29793128/convolutional-neural-networks-for-seizure-prediction-using-intracranial-and-scalp-electroencephalogram
#2
Nhan Duy Truong, Anh Duy Nguyen, Levin Kuhlmann, Mohammad Reza Bonyadi, Jiawei Yang, Samuel Ippolito, Omid Kavehei
Seizure prediction has attracted growing attention as one of the most challenging predictive data analysis efforts to improve the life of patients with drug-resistant epilepsy and tonic seizures. Many outstanding studies have reported great results in providing sensible indirect (warning systems) or direct (interactive neural stimulation) control over refractory seizures, some of which achieved high performance. However, to achieve high sensitivity and a low false prediction rate, many of these studies relied on handcraft feature extraction and/or tailored feature extraction, which is performed for each patient independently...
May 7, 2018: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/29792913/comparison-of-cerebral-ventricular-volumes-and-cortical-thicknesses-in-normal-rats-and-genetic-absence-epilepsy-gaers-a-developmental-study
#3
Özlem Kirazlı, Hüsniye Hacıoğlu Bay, Yusuf Özgür Çakmak, Filiz Onat, Safiye Çavdar
Ventricular enlargement and cortical atrophy have been associated with various central nervous system diseases. The aim of the present study was to measure the volumes of the lateral (LV) and third (3V) ventricles and to determine the cortical thickness for the motor (MCx), somatosensory (SSCx), visual (VCx) and auditory (AuCx) cortex and the striatum of Wistar rats, in a developmental series at 10, 20, 30, and 60 days postnatal, and to compare them with similar data from genetic absence epilepsy rats from Strasbourg (GAERS)...
May 21, 2018: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/29792345/dysembryoplastic-neuroepithelial-tumours-clinical-radiological-pathological-features-and-outcome
#4
Cihan Isler, Ozdem Erturk Cetin, Doga Ugurlar, Cigdem Ozkara, Nil Comunoglu, Osman Kizilkilic, Buge Oz, Yasemin Kayadibi, Taner Tanriverdi, Mustafa Uzan
OBJECT: To analyse the clinical, imaging and histopathological data of patients who were diagnosed to have Dysembrioplastic Neuroepithelial Tumour (DNET) and underwent surgery between 1995-2015. MATERIALS AND METHODS: Age at seizure onset, age at surgery, gender, disease duration, seizure outcome of 44 patients were analysed together with Magnetic Resonance Imaging (MRI) of 21 patients. MRI types were classified as type 1 (cystic/polycystic-like, well-delineated, strongly hypointense T1), type 2 (nodularlike,heterogeneous), type 3 (dysplastic-like, iso/hyposignal T1, poor delineation, gray-white matter blurring)...
May 24, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29792126/neuropathological-profile-of-the-pentylenetetrazol-ptz-kindling-model
#5
E Samokhina, Alexander Samokhin
Epilepsy is a complex neurological disease characterized by spontaneous episodes of abnormal, simultaneous firing of a neuronal population and disturbances of consciousness (so-called seizures) of unknown cause. Antiepileptic drugs are only symptomatic treatment, and there is a strong demand for the search of an alternative treatment of epilepsy. For this purpose, animal models of epilepsy are an important prerequisite. There are various animal models with chronic brain dysfunctions thought to reflect the processes underlying human epilepsy...
May 23, 2018: International Journal of Neuroscience
https://www.readbyqxmd.com/read/29791945/global-health-epilepsy
#6
Amza Ali
Epilepsy is a frequently misunderstood and highly stigmatized condition. Major treatment gaps exist across the world, most so in areas of financial constraint. Classification permits the best approaches to treatment and to ascertaining prognosis. The International League Against Epilepsy's new classification system emphasizes clinical aspects and utilizes all available resources to determine whether it is a focal or generalized epilepsy. The most important tools are a careful history, clinical examination, electroencephalography, and appropriate neuroimaging...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791941/understanding-refugees-health
#7
Martin Müller, Dana Khamis, David Srivastava, Aristomenis K Exadaktylos, Carmen Andrea Pfortmueller
According to the United Nations Refugee Agency (UNHCR), 65.6 million people have been forcibly displaced worldwide. Several factors have a major influence on asylum seekers' health; so, their health profile is markedly different from that of the population in the country of asylum. The aim of this study is to review the major issues physicians need to be aware of when treating asylum seekers, with a special focus on the neurological problems of asylum seekers and refugees. The major impact factors on refugees' health are linked to experiences and exposure (1) in the country of origin, (2) in refugee camps and en route to Europe, and (3) in the process of immigration into the host country and living in European asylum centers...
April 2018: Seminars in Neurology
https://www.readbyqxmd.com/read/29791932/b3galnt2-related-dystroglycanopathy-expansion-of-the-phenotype-with-novel-mutation-associated-with-muscle-eye-brain-disease-walker-warburg-syndrome-epileptic-encephalopathy-west-syndrome-and-sensorineural-hearing-loss
#8
Muna A Al Dhaibani, Ayman W El-Hattab, Omar Ismayl, Jehan Suleiman
Mutations in B3GALNT2 , encoding a glycosyltransferase enzyme involved in α-dystroglycan glycosylation, have been recently associated with dystroglycanopathy, a well-recognized subtype of congenital muscular dystrophy (CMD). Only a few cases have been reported with B3GALNT2 -related dystroglycanopathy with variable severity ranging from mild CMD to severe muscle-eye-brain disease. Here, we describe a child with a novel homozygous nonsense mutation in B3GALNT2 . The affected child has severe neurological disease since birth, including muscle disease manifested as hypotonia, muscle weakness, and wasting with elevated creatine kinase, eye disease including microphthalmia and blindness, brain disease with extensive brain malformations including massive hydrocephalus, diffuse cobblestone-lissencephaly, deformed craniocervical junction, and pontocerebellar hypoplasia...
May 23, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/29791879/seizure-imitators-monitored-using-video-eeg-in-children-with-intellectual-disabilities
#9
Riyo Ueda, Yuko Shimizu-Motohashi, Kenji Sugai, Eri Takeshita, Akihiko Ishiyama, Takashi Saito, Hirofumi Komaki, Eiji Nakagawa, Masayuki Sasaki
Diagnosis of seizure imitators in children is often challenging, and individuals with intellectual disability (ID) could be at additional risk of seizure imitator misdiagnosis. We aimed to elucidate distinct features of clinical semiology among children of different intellectual levels, which may help in distinguishing seizure imitators from epilepsy in such individuals. We retrospectively compared semiological features of seizure imitators in children with and without ID captured using video-electroencephalography (video-EEG)...
May 20, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29791747/commentary-on-the-impact-of-nonadherence-to-antiseizure-drugs-on-seizure-outcomes-in-an-animal-model-of-epilepsy
#10
Wolfgang Löscher
No abstract text is available yet for this article.
May 23, 2018: Epilepsia
https://www.readbyqxmd.com/read/29791724/resolving-ambiguities-in-sudep-classification
#11
Orrin Devinsky, Elizabeth Bundock, Dale Hesdorffer, Elizabeth Donner, Brian Moseley, Esma Cihan, Fizza Hussain, Daniel Friedman
OBJECTIVE: To examine the consistency of applying the Nashef et al (2012) criteria to classify sudden unexpected death in epilepsy (SUDEP). METHODS: We reviewed cases from the North American SUDEP Registry (n = 250) and Medical Examiner Offices (n = 1301: 698 Maryland, 457 New York City, 146 San Diego). Two epileptologists with expertise in SUDEP and epilepsy-related mortality independently reviewed medical records, scene investigation, autopsy, and toxicology and assigned a SUDEP class...
May 23, 2018: Epilepsia
https://www.readbyqxmd.com/read/29791065/risk-factors-of-valproic-acid-induced-hyperammonaemia-in-chinese-paediatric-patients-with-epilepsy
#12
Xu Zhu, Xinlin Li, Ti Zhang, Limei Zhao
The present study was aimed at identifying genetic and non-genetic risk factors for valproic acid (VPA)-induced hyperammonaemia in Chinese paediatric patients with epilepsy. A total of 210 epileptic patients, treated with VPA as monotherapy, were enrolled and classified into hyperammonaemia and control groups according to their blood ammonia level (cut-off value 50 μmol/L). Serum concentrations of VPA and its major metabolites were simultaneously determined by ultra-high performance liquid chromatography-tandem mass spectrometry...
May 23, 2018: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/29791030/antiepileptic-drugs-as-prophylaxis-for-postcraniotomy-seizures
#13
REVIEW
Janette Greenhalgh, Jennifer Weston, Yenal Dundar, Sarah J Nevitt, Anthony G Marson
BACKGROUND: This is an updated version of the Cochrane Review previously published in Issue 3, 2015.The incidence of seizures following supratentorial craniotomy for non-traumatic pathology has been estimated to be between 15% to 20%; however, the risk of experiencing a seizure appears to vary from 3% to 92% over a five-year period. Postoperative seizures can precipitate the development of epilepsy; seizures are most likely to occur within the first month of cranial surgery. The use of antiepileptic drugs (AEDs) administered pre- or postoperatively to prevent seizures following cranial surgery has been investigated in a number of randomised controlled trials (RCTs)...
May 23, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29791014/interaction-between-abcg2-421c-a-polymorphism-and-valproate-in-their-effects-on-steady-state-disposition-of-lamotrigine-in-adults-with-epilepsy
#14
Iva Klarica Domjanović, Mila Lovrić, Vladimir Trkulja, Željka Petelin-Gadže, Lana Ganoci, Ivana Čajić, Nada Božina
No abstract text is available yet for this article.
May 23, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29790814/a-de-novo-mutation-in-prickle1-associated-with-myoclonic-epilepsy-and-autism-spectrum-disorder
#15
Brittany P Todd, Alexander G Bassuk
Homozygous recessive mutations in the PRICKLE1 gene were first described in three consanguineous families with myoclonic epilepsy. Subsequent studies have identified neurological abnormalities in humans and animal models with both heterozygous and homozygous mutations in PRICKLE1 orthologs. We describe a 7-year-old with a novel de novo missense mutation in PRICKLE1 associated with epilepsy, autism spectrum disorder and global developmental delay.
May 23, 2018: Journal of Neurogenetics
https://www.readbyqxmd.com/read/29790568/-social-cognition-and-cognitive-functions-in-patients-with-epilepsy-treated-with-eslicarbazepine-acetate
#16
L Abraira, A Sanabria, G Ortega, M Quintana, E Santamarina, J Salas-Puig, M Toledo
INTRODUCTION: Epilepsy is accompanied by cognitive disorders, frequently aggravated by the use of antiepileptic drugs, which can affect social empathy. AIM: To analyse the impact of treatment with eslicarbazepine acetate (ESL) on social cognition and prefrontal cognitive functions in adults with focal epilepsy. PATIENTS AND METHODS: We conducted a prospective single-centre study with patients aged between 18 and 65 years with focal seizures treated with ESL...
June 1, 2018: Revista de Neurologia
https://www.readbyqxmd.com/read/29790469/intraventricular-ganglioglioma-presenting-with-spontaneous-hemorrhage
#17
Alexandre Rainha Campos, Luisa Biscoito, Maria Gabriela Gasparinho
Intraventricular gangliogliomas presenting with spontaneous hemorrhage are rare. Due to high density of important tracts lateral to the ventricular atrium, the intraparietal trans sulcal approach is a good option to remove lesions in this location. These tracts are displaced and sometimes destroyed by the presence of large masses. A 33-year-old male presented with a sudden headache and a generalized seizure. He had a left visual field hemianopia and left visual field neglect. Brain computer tomography and magnetic resonance imaging revealed a hemorrhagic tumor located in his right atrium...
March 29, 2018: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/29790195/a-licence-to-drive-neurological-illness-loss-and-disruption
#18
Melissa Stepney, Susan Kirkpatrick, Louise Locock, Suman Prinjha, Sara Ryan
The sense of freedom and independence that being able to drive generates may be taken for granted by many until it is threatened by illness. Drawing on the 'mobility turn' in social sciences that emphasises the social and emotional significance of the car (Sheller and Urry , ), this article presents secondary analysis of narratives of driving and its significance across four neurological conditions (epilepsy, Parkinson's disease, transient ischaemic attack and motor neurone disease). Taking an interactionist approach we explore how the withdrawal of a driving licence can represent not just a practical and emotional loss of independence, but also loss of enjoyment; of a sense and feeling of 'normal' adulthood and social participation; and of an identity (in some cases gendered) of strength and power...
May 22, 2018: Sociology of Health & Illness
https://www.readbyqxmd.com/read/29790011/consecutive-occurrence-of-benign-epilepsy-with-centro-temporal-spike-and-childhood-absence-epilepsy-true-coexistence-or-atypical-evolution
#19
EDITORIAL
Eun Hye Lee, Hoi Soo Yoon
No abstract text is available yet for this article.
May 22, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29789596/cervical-vagus-nerve-morphometry-and-vascularity-in-the-context-of-nerve-stimulation-a-cadaveric-study
#20
Niels Hammer, Sabine Löffler, Yusuf Ozgur Cakmak, Benjamin Ondruschka, Uwe Planitzer, Michael Schultz, Dirk Winkler, David Weise
Vagus nerve stimulation (VNS) has become a well-established therapy for epilepsy and depression, and is emerging to treat inflammatory disease, with the cervical vagus nerve (CVN) as major stimulation site. CVN morphometries are missing for VNS, considering its variability. Morphometric data were obtained from CVNs in 27 cadavers, including branching patterns and histology. Cross-sectional area, greater and lesser diameters averaged 7.2 ± 3.1 mm2 , 5.1 ± 1.5 and 4.1 ± 1.3 mm, and were ≤11...
May 22, 2018: Scientific Reports
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