poisions

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Objective: This study focused on the proteomicchanges between workers exposed to methylbenzene (WMB) and healthy individuals (HI) . Methods: The serum of WMB and HI was collected and the unmarked label free mass spectrometry was utilized for protein identification and quantitative comparison. The differentlyexpressed proteins in WMB and the HI were screened, followed by the analysis of protein and biological functions by bioinformatics tools. Results: Thirty nine proteins were differently expressed between WMB and HI...

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OBJECTIVE: To investigate the effects of thalidomide in a mouse model of paraquat-induced acute lung injury and the mechanisms underlying the properties of thalidomide. METHODS: Male ICR mice were randomly allocated into four groups: nomal control group (n = 30), thalidomide control group (n = 30), paraquat poisioning group (n = 30) and thalidomide treatment group (n = 90). Mice were sacrificed at 1d, 3d and 7d after paraquat poisioning. The level of (MDA) malondialdehyde, Superoxidedi-smutase (SOD) and glutathione (GSH) in the lung tissue were measuerd by chemical colorimetry...

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Amlodipine poisoning is an uncommon presentation with potentially life threatening complications. As there are few cases of severe poisoning documented, management guidelines are limited. The authors present the case of a 22-year-old female who presented to hospital 6 h after ingesting 280 mg of amlodipine. She was treated with aggressive fluid resuscitation and calcium gluconate infusion. She went on to develop acute non-cardiogenic pulmonary odema for which she needed a frusemide infusion. She stayed in hospital for 5 days and was discharged after a psychiatric review with no long-term complications...

The catalyst CuSO4-CeO2/TiO2-SiO2 (CuSO4-CeO2/TS), for low temperature catalytic reduction (LT-SCR) of NO with NH was prepared by the impregnation method. The impacts of H2O and SO2 on the catalyst were investigated. Experiments showed that H2O brought down the catalyst's activity at low reaction temperature. However, this negative effect of H2O could be mostly eliminated with a raised temperature of above 220 degrees C. In a 10-hour experiment on the catalyst's resistibility to SO2 poisoning, NO conversion increased slightly by the promoting effect of SO2...

In 1991 I was working as an administration officer at a school in North Queensland. I worked with two other women in a very small office and there were three other offices nearby, each with one person in them. The education department decided to put down new flooring around these offices, down the adjoining stairway and along the adjoining hallway. The new flooring was made up of coloured chips spread over the floor coated by a two part resin. At the time the flooring was being laid, the weather was very wet and humid...

To investigate the therapeutic effect of high-dosage gamma-aminobutyric acid (GABA) on acute tetramine (TET) poisoning, 50 Kunming mice were divided into 5 groups at random and the antidotal effects of GABA or sodium dimercaptopropane sulfonate (Na-DMPS) on poisoned mice in different groups were observed in order to compare the therapeutic effects of high-dosage GABA with those of Na-DMPS. Slices of brain tissue of the poisoned mice were made to examine pathological changes of cells. The survival analysis was employed...

Epidemic food poisioning caused by food contaminated by microorganisms, its toxins or chemical toxic substances, emerge in the hospitals as specific kind of intrahospital infections. An occurrence of food poisoning in hospitals is facilitated by several facts as: centralized food preparation, kinds of food, staff carriers, an unfavourable hygienic regime in the kitchens and at the places where food is shared, crossing of clean and unclean paths in a kitchen, carelessness, non-education etc. Danger that contaminated food brought to hospitals is more serious since it is about consumers with disrupted health...

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OBJECTIVE: To investigate the distribution of mophine in organs in cases with morphine poisioning to select ideal organs for immunohistochemical derection. METHODS: Localization and half quantitation of morphine in the brain, the kidney, the heart, and the liver were studied in 8 cases with morphine poisoning by immunohistochemical SP method. RESULTS: Morphine was mainly detected in the cytoplasm of certain parenchymal cells of the organs...

BACKGROUND: The UK Government's White Paper Saving Lives: Our Healthier Nation included among its targets a reduction in suicide. AIMS: To study causes of change in suicide rate over a 30-year period in Newcastle upon Tyne. METHOD: Suicide rates and methods, based on coroners' inquest records, were compared over two periods (1961-1965 and 1985-1994) and differences were related to changes in exposure to poisions and prescribed drugs, and to socio-demographic changes...

Despite difficulties in the interpretation of available data, certain general observations can be made on the epidemiology of poisioning. Childhood poisoning is usually accidental and tends to be associated with a low morbidity and mortality. In Western Europe and North America, it is most often due to household products and pharmaceuticals; in developing countries, paraffin, traditional medicines , snakes bites and insect stings are more commonly involved. In adults, self-poisoning is usually deliberate (suicide or parasuicide) and has a higher morbidity and mortality rate...

There was considerable agreement between 50 psychiatrists in their choices of reasons to explain patients' overdoses after reading transcripts of interviews with self-poisoning patients. The reasons attributed in each case were similar to those chosen by three psychiatrists in an earlier study. Most psychiatrists chose more than one reason for each case. Multidimensional scaling analysis of the psychiatrists' choices across the cases suggested four groups of reasons: (a) directed at some significant person; (b) help-seeking; (c) self-referring; (d) suicidal intent...

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No abstract text is available yet for this article.

An emergency drug screening system for the separation and identification of toxic drugs, MULTI-HPLC, is presented. Chromatographic peaks, which were impossible to identify with a conventional high-performance liquid chromatographic UV detection system, became distinguishable by the spectral search and retention prediction of the data-processing program MCASYST. Sixty-five toxic drugs, frequently identified in drug poisionings in Japan, were selected as references in the drug library. Retention time, optimum detection wavelength, detection limit and recoveries from serum and urine were listed...

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