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https://www.readbyqxmd.com/read/27912771/a-dna-vaccine-encoding-the-viral-hemorrhagic-septicemia-virus-genotype-ivb-glycoprotein-confers-protection-in-muskellunge-esox-masquinongy-rainbow-trout-oncorhynchus-mykiss-brown-trout-salmo-trutta-and-lake-trout-salvelinus-namaycush
#1
Isaac F Standish, Elena V Millard, Travis O Brenden, Mohamed Faisal
BACKGROUND: The viral hemorrhagic septicemia virus (VHSV) is one of the most serious fish pathogens. In 2003, a novel sublineage (genotype IVb) of this deadly virus emerged in the Great Lakes basin causing serious fish kills. We have previously demonstrated that a DNA plasmid (pcDNA), containing a cytomegalovirus (CMV) promoter and the viral hemorrhagic septicemia virus (VHSV) genotype IVb glycoprotein (G) gene insert (designated pVHSivb-G) confers moderate protection in muskellunge (Esox masquinongy), a highly susceptible species upon challenge...
December 2, 2016: Virology Journal
https://www.readbyqxmd.com/read/27910092/management-of-atrial-fibrillation-in-elderly-adults
#2
Yaanik Desai, Mikhael F El-Chami, Angel R Leon, Faisal M Merchant
Driven in large part by the aging of the population and the increasing prevalence of cardiovascular comorbidities associated with atrial fibrillation (AF), there is a burgeoning epidemic of AF in elderly adults. Although there is a large body of literature to guide management of people with AF, elderly adults with AF are frequently underrepresented in clinical trials. This review provides a contemporary update on management of elderly adults with AF with a particular focus on the two main clinical challenges that AF poses: stroke risk reduction and control of symptoms...
December 2, 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27909538/pulmonary-vein-remodeling-following-atrial-fibrillation-ablation-implications-for-the-radiographic-diagnosis-of-pulmonary-vein-stenosis
#3
Faisal M Merchant Md, Mathew R Levy Bs, Shahriar Iravanian Md, Ramal M Weragoda Md, Edward C Clermont Md, Heval M Kelli Md, Robert L Eisner PhD, David Vadnais Md, Mikhael F El-Chami Md, Angel R Leon Md, David B Delurgio Md
Background: Pulmonary vein (PV) reverse remodeling has been recognized following atrial fibrillation (AF) ablation. However, the extent of physiologic reverse remodeling after AF ablation and the potential impact of reverse remodeling on the radiographic diagnosis of PV stenosis have not been well characterized. Methods: From January 2004 to February 2014, 186 patients underwent paired cardiac magnetic resonance imaging (MRI) to delineate PV orifice dimensions before and after (mean 109 ± 61 days) an initial AF ablation...
August 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909476/atrial-fibrillation-and-risk-of-dementia-cognitive-decline
#4
REVIEW
Anand D Shah Md, Faisal M Merchant Md, David B Delurgio Md
Emerging evidence suggests a link between atrial fibrillation and subsequent development of dementia. While a majority of risk can be attributed to cardioembolic stroke secondary to atrial fibrillation, additional risk is apparent, and may be driven by vascular inflammation and changes in cerebral perfusion. Medical therapies including anticoagulation, statin therapy, and angiotensin-renin-aldosterone axis antagonists may reduce dementia risk. Procedural therapies such as atrial fibrillation catheter ablation and left atrial appendage closure may also prove to be important mediators of acute and long-term risk...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27908249/automated-system-for-referral-of-cotton-wool-spots
#5
Syed Ali Gohar Naqvi, Hafiz Muhammad Faisal Zafar, Ihsan Ul Haq
BACKGROUND: Cotton-wool spots also referred as soft exudates are the early sign of complications in the eye fundus of the patients suffering from diabetic retinopathy. Early detection of exudates helps in diagnosis of the disease and provides better medical attention. METHODS: In the paper an automated system for detection of soft exudates has been suggested. The system has been developed by the combination of different techniques like scale invariant feature transform (SIFT), Visual Dictionaries, K-means clustering and support vector machine (SVM)...
December 1, 2016: Current Diabetes Reviews
https://www.readbyqxmd.com/read/27906795/factors-determining-the-outcome-of-hematopoietic-stem-cell-transplantation-in-patients-with-acute-lymphoblastic-leukemia-at-king-faisal-specialist-hospital-and-research-center-riyadh-saudi-arabia
#6
Suleimman Al-Sweedan, Amal Al-Seraihy, Ali Al-Ahmari, Abdullah Al-Jefri, Viqaruddin Mohammed, Rafat Jafri, Khawar Siddiqui, Mouhab Ayas
Medical records of 82 patients with acute lymphoblastic leukemia (ALL) who underwent hematopoietic cell transplantation (HCT) at our institution from 2005 to 2011 were reviewed. Forty-five patients were male (54.8%). The median age at HCT was 7.46 years (range, 0.98 to 14.31 y), the median time to HCT after diagnosis was 12.56 months. Ten patients were below the age of 1 year (12%). All patients were in complete remission at the time of HCT. In 83 transplants, 64 patients received HCT from human leukocyte antigen-identical-related donors and 19 from other donors...
November 30, 2016: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/27903672/-exertional-dyspnoea-in-copd-the-clinical-utility-of-cardiopulmonary-exercise-testing-denis-e-o-donnell-amany-f-elbehairy-azmy-faisal-katherine-a-webb-j-alberto-neder-and-donald-a-mahler-eur-respir-rev-2016-25-333-347
#7
(no author information available yet)
No abstract text is available yet for this article.
December 2016: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/27900802/therapeutic-potential-of-carfilzomib-an-irreversible-proteasome-inhibitor-against-acetaminophen-induced-hepatotoxicity-in-mice
#8
Abdulrazaq Alanazi, Saleh G Algfeley, Khaled A Al-Hosaini, Hesham M Korashy, Faisal Imam, Mahmoud N Nagi
Overdose of acetaminophen (APAP) is often associated with hepatotoxicity. Carfilzomib (CFZ) shows multiple pharmacological activities including anti-inflammatory potential. Therefore, this study was undertaken to evaluate the possible therapeutic effects of CFZ against APAP-induced hepatotoxicity. Hepatotoxicity was induced by administration of APAP (350 mg/kg, intraperitoneal). Mice were given CFZ (0.125, 0.25, or 0.5 mg/kg, intraperitoneal) 1.5 h after APAP administration. Animals were sacrificed on 6 h and blood and liver tissue samples were collected for analysis...
November 30, 2016: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/27896729/identifying-optimal-models-of-evolution
#9
Lars S Jermiin, Vivek Jayaswal, Faisal M Ababneh, John Robinson
Most phylogenetic methods are model-based and depend on models of evolution designed to approximate the evolutionary processes. Several methods have been developed to identify suitable models of evolution for phylogenetic analysis of alignments of nucleotide or amino acid sequences and some of these methods are now firmly embedded in the phylogenetic protocol. However, in a disturbingly large number of cases, it appears that these models were used without acknowledgement of their inherent shortcomings. In this chapter, we discuss the problem of model selection and show how some of the inherent shortcomings may be identified and overcome...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27894027/assessing-the-safety-effects-of-cooperative-intelligent-transport-systems-a-bowtie-analysis-approach
#10
Ute Christine Ehlers, Eirin Olaussen Ryeng, Edward McCormack, Faisal Khan, Sören Ehlers
The safety effects of cooperative intelligent transport systems (C-ITS) are mostly unknown and associated with uncertainties, because these systems represent emerging technology. This study proposes a bowtie analysis as a conceptual framework for evaluating the safety effect of cooperative intelligent transport systems. These seek to prevent road traffic accidents or mitigate their consequences. Under the assumption of the potential occurrence of a particular single vehicle accident, three case studies demonstrate the application of the bowtie analysis approach in road traffic safety...
November 25, 2016: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/27889044/leadless-pacemakers
#11
REVIEW
Mikhael F El-Chami, Faisal M Merchant, Angel R Leon
Leadless pacing is an emerging technology with the potential to significantly improve outcomes associated with the need for long-term pacing. Specifically, the major advantage of leadless systems is abolishing the need for transvenous leads and subcutaneous pockets, both of which account for most adverse events associated with traditional pacemakers. Two leadless pacemakers are currently available: the Nanostim (leadless cardiac pacemaker [LCP]) device (St. Jude Medical, Sylmar, California) and the Micra Transcatheter pacing system (Medtronic, Minneapolis, Minnesota)...
November 1, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27888123/acute-rhinosinusitis-during-hajj-season-2014-prevalence-of-bacterial-infection-and-patterns-of-antimicrobial-susceptibility
#12
Osama A Marglani, Ameen Z Alherabi, Islam R Herzallah, Faisal A Saati, Enas A Tantawy, Talal A Alandejani, Hani S Faidah, Naif A Bawazeer, Abdullah A Marghalani, Tariq A Madani
BACKGROUND: The presence of large number of pilgrims during Hajj in Makkah region increases the risk of respiratory diseases. In this study, we aimed to assess the bacteriology of acute rhinosinusitis (ARS) during Hajj season and to demonstrate the antimicrobial susceptibility patterns that should guide the clinicians towards more appropriate antibiotic use. METHODS: Patients with ARS presenting during Hajj season of 2014 were prospectively enrolled. According to EPOS2012 criteria...
November 23, 2016: Travel Medicine and Infectious Disease
https://www.readbyqxmd.com/read/27883917/osmotic-versus-conventional-membrane-bioreactors-integrated-with-reverse-osmosis-for-water-reuse-biological-stability-membrane-fouling-and-contaminant-removal
#13
Wenhai Luo, Hop V Phan, Ming Xie, Faisal I Hai, William E Price, Menachem Elimelech, Long D Nghiem
This study systematically compares the performance of osmotic membrane bioreactor - reverse osmosis (OMBR-RO) and conventional membrane bioreactor - reverse osmosis (MBR-RO) for advanced wastewater treatment and water reuse. Both systems achieved effective removal of bulk organic matter and nutrients, and almost complete removal of all 31 trace organic contaminants investigated. They both could produce high quality water suitable for recycling applications. During OMBR-RO operation, salinity build-up in the bioreactor reduced the water flux and negatively impacted the system biological treatment by altering biomass characteristics and microbial community structure...
November 12, 2016: Water Research
https://www.readbyqxmd.com/read/27882027/visual-outcome-of-laser-treatment-in-diabetic-macular-edema-study-from-an-urban-diabetes-care-center
#14
Rashid Alvi, Muhammad Saleh Memon, Samad Shera, Seema N Mumtaz, Sikander Ali Shaikh, Muhammad Faisal Fahim
OBJECTIVE: To determine the visual outcome of laser treatment in clinically significant macular edema. METHODS: This interventional and qausi experimental study was carried out at Diabetic Association of Pakistan (DAP) during January 2011 and December 2012. Approval was taken from Research Ethical Committee of Isra Postgraduate Institute of Ophthalmology. Records of 925 eyes of 464 patients with "Clinical Significant macular edema" (CSME), treated with laser photocoagulation were analyzed...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27882018/role-of-bevacizumab-in-the-prevention-of-early-postoperative-haemorrhage-after-25-gauge-microincision-vitrectomy-surgery
#15
Zaheer Sultan, Syed Fawad Rizvi, Faisal Murtaza Qureshi, Syed Asaad Mahmood
OBJECTIVE: To evaluate the effect of preoperative intravitreal bevacizumab injection on the incidence of postoperative haemorrhage and visual prognosis, in patients undergoing 25-gauge micro incision vitrectomy surgery (MIVS) for diabetic vitreous haemorrhage. METHODS: One hundred and twenty two eyes of 122 patients of diabetic retinopathy of both genders and aged over 18 years, who presented with non-resolving vitreous haemorrhage were enrolled for this study. All patients received an intravitreal injection of 1...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27882000/study-on-risk-factors-predisposing-factors-for-poor-diabetes-control-during-hajj-1436-2015-in-people-with-diabetes
#16
Gulshad Hasan, Hanan Moabber, Arwa Alyamani, Ahmed Sayeed, Faisal Altatar
BACKGROUND AND OBJECTIVE: Each year millions of Muslims perform pilgrimage to Makkah, Saudi Arabia. It is particularly stressful during the peak five days, when all rituals have to be performed at specific periods of time at different sites. Poor diabetes control in people with diabetes predisposes to morbidity and increases risk of acute complications. We wanted to see how well their blood glucose control was before coming to Hajj and whether they were aware, about self management of Diabetes and what were reasons for hospital admissions...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27881095/a-regional-consensus-recommendation-on-brain-atrophy-as-an-outcome-measure-in-multiple-sclerosis
#17
Raed Alroughani, Dirk Deleu, Khalid El Salem, Jasem Al-Hashel, K John Alexander, Mohamed Assem Abdelrazek, Adel Aljishi, Jaber Alkhaboori, Faisal Al Azri, Nahida Al Zadjali, Majed Hbahbih, Tag Eldin Sokrab, Mohamed Said, Àlex Rovira
BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease characterized by inflammatory and neurodegenerative processes leading to irreversible neurological impairment. Brain atrophy occurs early in the course of the disease at a rate greater than the general population. Brain volume loss (BVL) is associated with disability progression and cognitive impairment in patients with MS; hence its value as a potential target in monitoring and treating MS is discussed. METHODS: A group of MS neurologists and neuro-radiologists reviewed the current literature on brain atrophy and discussed the challenges in assessing and implementing brain atrophy measurements in clinical practice...
November 24, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27878635/the-focal-hepatic-hot-spot-hot-quadrate-sign
#18
REVIEW
Faisal Fahad Aloufi, Faisal Mohammed Alabdulkarim, Meshal Ali Alshahrani
No abstract text is available yet for this article.
November 23, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27878139/compound-heterozygous-ldlr-variant-in-severely-affected-familial-hypercholesterolemia-patient
#19
Faisal A Al-Allaf, Abdullah Alashwal, Zainularifeen Abduljaleel, Mohiuddin M Taher, Abdellatif Bouazzaoui, Hala Abalkhail, Ahmad F Al-Allaf, Mohammad Athar
Familial hypercholesterolemia (FH) is most commonly caused by mutations in the LDL receptor (LDLR), which is responsible for hepatic clearance of LDL from the blood circulation. We described a severely affected FH proband and their first-degree blood relatives; the proband was resistant to statin therapy and was managed on an LDL apheresis program. In order to find the causative genetic variant in this family, direct exon sequencing of the LDLR, APOB and PCSK9 genes was performed. We identified a compound heterozygous mutation in the proband with missense p...
November 23, 2016: Acta Biochimica Polonica
https://www.readbyqxmd.com/read/27875161/investigating-the-use-of-a-dynamic-physical-bar-chart-for-data-exploration-and-presentation
#20
Faisal Taher, Yvonne Jansen, Jonathan Woodruff, John Hardy, Kasper Hornbaek, Jason Alexander
Physical data representations, or data physicalizations, are a promising new medium to represent and communicate data. Previous work mostly studied passive physicalizations which require humans to perform all interactions manually. Dynamic shape-changing displays address this limitation and facilitate data exploration tasks such as sorting, navigating in data sets which exceed the fixed size of a given physical display, or preparing "views" to communicate insights about data. However, it is currently unclear how people approach and interact with such data representations...
January 2017: IEEE Transactions on Visualization and Computer Graphics
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