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https://www.readbyqxmd.com/read/28927226/female-clock%C3%AE-19-%C3%AE-19-mice-are-protected-from-the-development-of-age-dependent-cardiomyopathy
#1
Faisal J Alibhai, Cristine J Reitz, Willem T Peppler, Poulami Basu, Paul Sheppard, Elena Choleris, Marica Bakovic, Tami A Martino
Aims: Circadian rhythms are important for healthy cardiovascular physiology and they are regulated by the molecular circadian mechanism. Previously, we showed that disruption of the circadian mechanism factor CLOCK in male Clock Δ19/Δ19 mice led to development of age-dependent cardiomyopathy. Here, we investigate the role of biological sex in protecting against heart disease in aging female Clock Δ19/Δ19 mice. Methods and results: Female Clock Δ19/Δ19 mice are protected from the development of cardiomyopathy with age, as heart structure and function are similar to 18 months of age versus female WT mice...
September 12, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28921884/structural-characterization-and-functional-analysis-of-cystathionine-%C3%AE-synthase-an-enzyme-involved-in-the-reverse-transsulfuration-pathway-of-bacillus-anthracis
#2
Suneeta Devi, Syed Arif Abdul Rehman, Khaja Faisal Tarique, Samudrala Gourinath
The reverse transsulfuration pathway has been reported to produce cysteine from homocysteine in eukaryotes ranging from protozoans to mammals while bacteria and plants produce cysteine via a de-novo pathway. Interestingly, the bacterium Bacillus anthracis includes enzymes of the reverse transsulfuration pathway viz. cystathionine β-synthase (BaCBS, previously annotated to be an O-acetylserine sulfhydrylase (OASS)) and cystathionine γ-lyase. Here, we report the structure of BaCBS at a resolution of 2.2 Å...
September 16, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28917680/effusive-constrictive-pericarditis-after-pericardiocentesis-incidence-associated-findings-and-natural-history
#3
Kye Hun Kim, William R Miranda, Larry J Sinak, Faisal F Syed, Rowlens M Melduni, Raul E Espinosa, Garvan C Kane, Jae K Oh
OBJECTIVES: This study sought to investigate the incidence, associated findings, and natural history of effusive-constrictive pericarditis (ECP) after pericardiocentesis. BACKGROUND: ECP is characterized by the coexistence of tense pericardial effusion and constriction of the heart by the visceral pericardium. Echocardiography is currently the main diagnostic tool in the assessment of pericardial disease, but limited data have been published on the incidence and prognosis of ECP diagnosed by echo-Doppler...
September 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28915161/unenhanced-dual-energy-computed-tomography-visualization-of-brain-edema
#4
Mohammed F Mohammed, Olivia Marais, Adam Min, David Ferguson, Sabeena Jalakhan, Faisal Khosa, Michael OʼKeeffe, Tim OʼConnell, Heiko Schmiedeskamp, Bernhard Krauss, Axel Rohr, Savvas Nicolaou
PURPOSE: The aim of this study was to determine whether dual-energy computed tomography (DECT) imaging is superior to conventional noncontrast computed tomography (CT) imaging for the detection of acute ischemic stroke. MATERIALS AND METHODS: This was a retrospective, single-center study of 40 patients who presented to the emergency department (ED) of a major, acute care, teaching center with signs and symptoms of acute stroke. Only those patients who presented to the ED within 4 hours of symptom onset were included in this study...
September 14, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28906478/complementary-rna-sequencing-based-transcriptomics-and-itraq-proteomics-reveal-the-mechanism-of-the-alleviation-of-quinclorac-stress-by-salicylic-acid-in-oryza-sativa-ssp-japonica
#5
Jian Wang, Faisal Islam, Lan Li, Meijuan Long, Chong Yang, Xiaoli Jin, Basharat Ali, Bizeng Mao, Weijun Zhou
To uncover the alleviation mechanism of quinclorac stress by salicylic acid (SA), leaf samples of Oryza sativa ssp. Japonica under quinclorac stress with and without SA pre-treatment were analyzed for transcriptional and proteomic profiling to determine the differentially expressed genes (DEGs) and proteins (DEPs), respectively. Results showed that quinclorac stress altered the expression of 2207 DEGs (1427 up-regulated, 780 down-regulated) and 147 DEPs (98 down-regulated, 49 up-regulated). These genes and proteins were enriched in glutathione (GSH) metabolism, porphyrin and chlorophyll metabolism, the biosynthesis of secondary metabolites, glyoxylate and dicarboxylate metabolism, and so on...
September 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28903867/detection-accuracy-of-renibacterium-salmoninarum-in-chinook-salmon-oncorhynchus-tshawytscha-walbaum-from-non-lethally-collected-samples-effects-of-exposure-route-and-disease-severity
#6
Carolyn A Richards, Cheryl A Murphy, Travis O Brenden, Thomas P Loch, Mohamed Faisal
Bacterial kidney disease (BKD), caused by Renibacterium salmoninarum, threatens salmonid populations throughout the Northern hemisphere. Many fishery regulatory authorities require ongoing disease monitoring in hatcheries and spawning runs prior to gamete collection to prevent BKD outbreaks and spread. According to diagnostic protocols of the American Fisheries Society-Fish Health Section, monitoring for R. salmoninarum generally consists of lethal sampling of visceral organs from fish. However, non-lethal sampling would be preferable, especially for valuable broodstock or endangered species...
September 15, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28903837/impact-of-different-treatment-modalities-on-the-outcome-of-pancreatic-cancer
#7
Misbah Khan, Muhammad Ijaz Ashraf, Aamir Ali Syed, Faisal Hanif
OBJECTIVE: To analyze overall survival patterns of our pancreatic cancer patient population managed with a curative or palliative intent. STUDY DESIGN: Analytical study. PLACE AND DURATION OF STUDY: Shaukat Khanum Memorial Cancer Hospital and Research Centre, Lahore, from January 2000 till February 2015. METHODOLOGY: Aretrospective review of the data of all of our pancreatic cancer patients was performed, using the hospital information system...
August 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28899497/molecular-targets-and-anticancer-potential-of-sanguinarine-a-benzophenanthridine-alkaloid
#8
REVIEW
Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil
BACKGROUND: Cancer is an enormous global health burden, and should be effectively addressed with better therapeutic strategies. Currently, over 60% of the clinically approved anticancer agents are either directly isolated from natural sources or are modified from natural lead molecules. Sanguinarine (SNG), a quaternary benzophenanthridine alkaloid has gained increasing attention in recent years as a potential anticancer agent. PURPOSE: There is a large untapped source of phytochemical-based anticancer agents remaining to be explored...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28893806/low-dose-intrapleural-alteplase-without-deoxyribonuclease-in-complicated-parapneumonic-effusion-case-series-and-literature-reviews
#9
Carol Lai, Nurashikin Mohammad, Tidi Maharani Hassan, Mohamed Faisal Abdul Hamid
This case series reviews two cases of elderly patients who presented with fever, cough and shortness of breath. Clinical examinations and initial chest radiographs confirmed unilateral pleural effusion. Thoracenteses were consistent with exudative pleural effusion. We commenced intravenous antibiotics treating for parapneumonic effusions. The first case showed persistent effusion despite drainage, and the second case had a little aspirate from pleural tapping. Subsequent ultrasound of the thorax showed multiloculated effusions...
September 11, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28893552/applicability-of-the-grip-strength-and-automated-von-frey-tactile-sensitivity-tests-in-the-mouse-photothrombotic-model-of-stroke
#10
Faisal F Alamri, Abdullah Al Shoyaib, Abbie Biggers, Srinidhi Jayaraman, Josée Guindon, Vardan T Karamyan
Improvement of impaired neurological function(s) is a primary endpoint in experimental stroke recovery studies, making the choice and nature of the functional tests crucial for proper execution and interpretation of such studies. Currently, there are a limited number of neurological tests which reliably evaluate functional deficit in mice over a long period of time after stroke. In this study, we evaluated the applicability of forepaw grip strength and automated von Frey tactile sensitivity tests to assess forelimb dysfunction in mice following photothrombosis in the sensorimotor cortex, and compared them with two well-established tests, grid-walking and cylinder, for up to 21days after stroke...
September 8, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28892988/treatment-of-proximal-humerus-fractures-using-philos-plate
#11
Chintan Doshi, Gaurav Mahesh Sharma, Lokesh Gudda Naik, Krishna Sudhakar Badgire, Faisal Qureshi
INTRODUCTION: Treatment of proximal humerus fractures always holds a dilemma for the treating surgeon. AIM: To assess the functional outcome of proximal humerus fractures treated with Proximal Humerus Internal Locking System (PHILOS) plating. MATERIAL AND METHODS: Fifty three consecutive patients were treated with PHILOS plating between August 2013 and August 2014. The inclusion criteria were skeletally matured patients with closed fracture proximal humerus with displacement >1 cm and varus angulation of >45(0)...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28889731/comparative-evaluation-of-hypoglycemic-and-hypolipidemic-activity-of-various-extract-of-anogeissus-latifolia-bark-in-streptozotocin-induced-diabetic-rats
#12
Subramaniam Ramachandran, Thekkin Kattil Faisal, Jose Anjumary, Aiyalu Rajasekaran, Kuppusamy Asokkumar, Kuppusamy Annadurai, Ramasamy Arivukkarasu, Rajeev Kumar Sharma, Madhira Bhavani Shankar
Background Anogeissus latifolia Wall. (A. latifolia) bark has been traditionally used in the treatment of various diseases which includes diabetes and general debility. The present study was aimed to investigate the comparative hypoglycemic and hypolipidemic activity of various extracts of A. latifolia bark in streptozotocin-induced type 1 diabetic rats. Methods Acute toxicity was carried out at 2 g/kg dose of petroleum ether extract of A. latifolia bark (PEALB), chloroform extract of A. latifolia bark (CEALB) and methanol extract of A...
June 22, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/28889136/electro-navigational-bronchoscopy-for-bilateral-peripheral-lung-lesions-a-case-report
#13
A H Faisal, A W Sopian, H Tidi
Electromagnetic navigational bronchoscopy (ENB), one of the methods of navigational bronchoscopy is an advanced diagnostic tool allowing tissue sampling at the lung peripheries which were previously accessible only by computed tomography (CT) guidance or video-assisted thoracoscopic surgery (VATS). We report a 53-year-old man who presented with a cough and dyspnea with constitutional symptoms for one month. CT thorax revealed multiple bilateral peripheral lung nodules and there were no endobronchial lesions on flexible bronchoscopy...
August 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/28888379/video-assisted-thoracoscopic-lobectomy-is-associated-with-greater-recurrence-free-survival-than-stereotactic-body-radiotherapy-for-clinical-stage-i-lung-cancer
#14
Lorraine D Cornwell, Alfredo E Echeverria, Jason Samuelian, Jessica Mayor, Roberto F Casal, Faisal G Bakaeen, Shuab Omer, Ourania Preventza, Weiyuan Mai, George Chen, Katherine H Simpson, Drew Moghanaki, Angela W Zhu
OBJECTIVE: Stereotactic body radiotherapy is the standard treatment for medically inoperable early-stage non-small cell lung cancer. Recent data suggest that in operable patients, stereotactic body radiotherapy produces outcomes comparable to those of surgical resection. In veterans with early non-small cell lung cancer, we compared the outcomes of stereotactic body radiotherapy and video-assisted thoracoscopic lobectomy. METHODS: We retrospectively reviewed data from 183 patients (94...
August 16, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28886677/unplanned-return-to-operating-room-after-endovascular-repair-of-abdominal-aortic-aneurysm-evar-is-associated-with-increased-risk-of-hospital-readmission
#15
Faisal Aziz, Katelynn Ferranti, Erik B Lehman
Objectives Hospital readmissions after surgical operations are considered serious events. Centers for Medicare and Medicaid (CMS) consider surgical readmissions as preventable and hold hospitals responsible for them. Endovascular abdominal aortic aneurysm (EVAR) has become the first line modality of treatment for suitable patients with abdominal aortic aneurysm (AAA). The purpose of this study is to retrospectively review the factors associated with hospital readmission after EVAR. Methods The 2013 EVAR targeted American College of Surgeons (ACS-NSQIP) database and generalized 2013 general and vascular surgery ACS-NSQIP participant use files were used for this study...
January 1, 2017: Vascular
https://www.readbyqxmd.com/read/28886564/efficient-photodecomposition-of-herbicide-imazapyr-over-mesoporous-ga2o3-tio2-nanocomposites
#16
Adel A Ismail, Ibrahim Abdelfattah, M Faisal, Ahmed Helal
The unabated release of herbicide imazapyr into the soil and groundwater led to crop destruction and several pollution-related concerns. In this contribution, heterogeneous photocatalytic technique was employed utilizing mesoporous Ga2O3-TiO2 nanocomposites for degrading imazapyr herbicide as a model pollutant molecule. Mesoporous Ga2O3-TiO2 nanocomposites with varied Ga2O3 contents (0-5wt%) were synthesized through sol-gel process. XRD and Raman spectra exhibited extremely crystalline anatase TiO2 phase at low Ga2O3 content which gradually reduced with the increase of Ga2O3 content...
August 23, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28886077/exploration-of-ethno-medicinal-knowledge-among-rural-communities-of-pearl-valley-rawalakot-district-poonch-azad-jammu-and-kashmir
#17
Humaira Shaheen, Mirza Faisal Qaseem, Muhammad Shoaib Amjad, Piero Bruschi
BACKGROUND: Medicinal plants are the basic source of health care in the Pearl Valley District Poonch, Azad Jammu, and Kashmir. The basic aim of present study was to record information about the use of plants in herbal preparation and quantification of recorded data. MATERIALS AND METHODS: The research was conducted with the null hypothesis that there was no differential distribution of knowledge among the communities between genders and among different age groups in the study area and across cultural medicinal uses of the plants are similar...
2017: PloS One
https://www.readbyqxmd.com/read/28886039/infection-prevention-and-control-practice-for-crimean-congo-hemorrhagic-fever-a-multi-center-cross-sectional-survey-in-eurasia
#18
Tom E Fletcher, Abuova Gulzhan, Salih Ahmeti, Seif S Al-Abri, Zahide Asik, Aynur Atilla, Nick J Beeching, Heval Bilek, Ilkay Bozkurt, Iva Christova, Fazilet Duygu, Saban Esen, Arjun Khanna, Çiğdem Kader, Masoud Mardani, Faisal Mahmood, Nana Mamuchishvili, Natalia Pshenichnaya, Mustafa Sunbul, Tuğba Y Yalcin, Hakan Leblebicioglu
BACKGROUND: Crimean Congo Hemorrhagic Fever (CCHF) is a life threatening acute viral infection that presents significant risk of nosocomial transmission to healthcare workers. AIM: Evaluation of CCHF infection prevention and control (IP&C) practices in healthcare facilities that routinely manage CCHF cases in Eurasia. METHODS: A cross-sectional CCHF IP&C survey was designed and distributed to CCHF centers in 10 endemic Eurasian countries in 2016...
2017: PloS One
https://www.readbyqxmd.com/read/28884917/molluscum-contagiosum-review-and-update-on-management
#19
REVIEW
Emily Forbat, Firas Al-Niaimi, Faisal R Ali
Molluscum contagiosum (MC) is an infectious dermatosis that commonly presents in children and immunocompromised individuals. Although lesions usually resolve spontaneously after several months, they can be symptomatic and cause psychosocial distress. We review the evidence underlying treatment methods available for MC lesions, including potassium hydroxide, salicylic acid, hydrogen peroxide, retinoids, cantharidin, cryotherapy, curettage, and pulsed dye laser to aid practicing dermatologists in therapy selection...
September 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28881485/indices-of-anti-dengue-immunoglobulin-g-subclasses-in-adult-mexican-patients-with-febrile-and-hemorrhagic-dengue-in-the-acute-phase
#20
Araceli Posadas-Mondragón, José Leopoldo Aguilar-Faisal, Adolfo Chávez-Negrete, Edith Guillén-Salomón, Verónica Alcántara-Farfán, Lucero Luna-Rojas, Amanda Marineth Ávila-Trejo, Judith Del Carmen Pacheco-Yépez
Heterologous secondary infections are at increased risk of developing dengue hemorrhagic fever (DHF) due to antibody-dependent enhancement (ADE). The immunoglobulin G (IgG) subclasses can fix and activate complement and bind to Fcɣ receptors. These factors may also play an important role in the development of ADE and thus in the pathogenesis of DHF. The aim of this study was to analyze the indices of anti-dengue IgG subclasses in adult patients with febrile and hemorrhagic dengue in the acute phase. In 2013, we recruited129 patients with dengue fever (DF) and 57 with DHF in Veracruz, Mexico...
September 7, 2017: Microbiology and Immunology
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