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Andrzej Wojtarowicz, Zdzisława Kornacewicz-Jach
BACKGROUND: Alcohol septal ablation (ASA) is a method of treatment in obstructive hypertrophic cardiomyopathy (HOCM), but there is little data on the long-term results of ASA and the natural course after treatment. The aim of the study was to evaluate the results of ASA in HOCM in multiannual observation, and its impact on patient survival, exercise capacity, electrical complications, and changes in the anatomy and function of the heart. METHODS: The study evaluated 47 patients with HOCM with a high left ventricular outflow tract (LVOT gradient) treated between 1997 and 2014 with ASA...
October 13, 2016: Cardiology Journal
Kevin Fu Hong Yee, Marcin Wasowicz
BACKGROUND: The aim of this paper is to describe clinical management in a situation where a patient has experienced anaphylaxis while undergoing surgical septal myectomy for hypertrophic obstructive cardiomyopathy (HOCM). CASE REPORT: A 40-yr-old female was scheduled to undergo surgical septal myectomy for the treatment of HOCM. After induction, the patient developed refractory hypotension that did not respond to escalating doses of vasopressors and volume therapy...
September 30, 2016: Anaesthesiology Intensive Therapy
Joon Hwa Hong, Hartzell V Schaff, Rick A Nishimura, Martin D Abel, Joseph A Dearani, Zhuo Li, Steve R Ommen
BACKGROUND: Incidence and outcome of mitral valve (MV) surgery are unknown in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing extended transaortic septal myectomy. OBJECTIVES: This study sought to define indications and suitable operative strategy for mitral regurgitation (MR) in patients with HOCM. METHODS: A total of 2,107 septal myectomy operations performed in adults from January 1993 to May 2014 at Mayo Clinic in Rochester, Minnesota, were retrospectively reviewed...
October 4, 2016: Journal of the American College of Cardiology
R Liu, S B Qiao, F H Hu, W X Yang, J S Yuan, J G Cui
Objective: To observe the long-term prognosis and related outcome predictors for hypertrophic obstructive cadiomyopathy (HOCM) patients underwent alcohol septal ablation (ASA). Methods: A total of 227 consecutive patients(age: (47.8±11.7) years) treated by ASA from September 2005 to December 2013 in our hospital were included and followed-up for 4.42 years(range: ( 1.17-9.93) years). Follow up rate is 97.4%(221/227). General information, medical history, data of ASA and complications during hospitalization were obtained through access to medical records of patients...
September 24, 2016: Zhonghua Xin Xue Guan Bing za Zhi
Chadi Ayoub, David Brieger, Richard Chard, John Yiannikas
We present a case series that highlights the diagnostic challenges with left ventricular hypertrophy (LVH) and left ventricular outflow tract obstruction (LVOTO). Fixed structural lesions causing LVOTO with secondary LVH may mimic hypertrophic obstructive cardiomyopathy (HOCM). Management of these two entities is critically different. Misdiagnosis and failure to recognize fixed left ventricular outflow tract (LVOT) lesions may result in morbidity as a result of inappropriate therapy and delay of definitive surgical treatment...
September 10, 2016: Echocardiography
Tolga Aksu, Tümer Erdem Güler, Kıvanç Yalın, Şükriye Ebru Gölcük, Kazım Serhan Özcan
Septal reduction therapy is accepted as a first therapeutic option for symptomatic drug-resistant hypertrophic obstructive cardiomyopathy (HOCM). Although, surgical septal myectomy is the gold standard method, alcohol septal ablation is a well-studied alternative approach in the patients with suitable anatomy. Endocardial septal ablation (ESA) therapy was relatively new defined modality and outcomes of the procedure were not clearly elucidated yet. We aimed to review the clinical aspects of ESA procedure and provide some historical background...
September 2016: Anatolian Journal of Cardiology
Ankit Chothani, Sidakpal S Panaich, Nilay Patel, Nileshkumar J Patel, Shilpkumar Arora, Abhishek Deshmukh, Cindy Grines, Apurva O Badheka
BACKGROUND: Septal ablation (SA) is a key modality for left ventricular outflow tract gradient reduction in hypertrophic obstructive cardiomyopathy (HOCM) patients with refractory symptoms. The primary objective of our study was to evaluate post-procedural mortality, complications, length of stay (LOS), and cost of hospitalization following SA. METHODS: We queried the Nationwide Inpatient Sample (NIS) between 2005 and 2011 using the ICD9 procedure code of 37.34 for ablation of heart tissue...
October 2016: Journal of Interventional Cardiology
Shi Sum Poon, Robert M Cooper, Dhiraj Gupta
No abstract text is available yet for this article.
November 1, 2016: International Journal of Cardiology
Vito Maurizio Parato, Valeria Antoncecchi, Fabiola Sozzi, Stefania Marazia, Annapaola Zito, Maria Maiello, Pasquale Palmiero
Hypertrophic Cardiomyopathy (HCM) is an inherited cardiovascular disorder of great genetic heterogeneity and has a prevalence of 0.1 - 0.2 % in the general population. Several hundred mutations in more than 27 genes, most of which encode sarcomeric structures, are associated with the HCM phenotype. Then, HCM is an extremely heterogeneous disease and several phenotypes have been described over the years. Originally only two phenotypes were considered, a more common, obstructive type (HOCM, 70 %) and a less common, non-obstructive type (HNCM, 30 %) (Maron BJ, et al...
2016: Cardiovascular Ultrasound
Israel Guerrero, Abhijeet Dhoble, Mark Fasulo, Ali E Denktas, Shehzad Sami, Sangbum Choi, Prakash Balan, Salman A Arain, Richard W Smalling
OBJECTIVE: The objective of this study was to evaluate safety, efficacy, and durability of coil embolization of the major septal perforator of the left anterior descending coronary artery in patients with hypertrophic obstructive cardiomyopathy (HOCM). BACKGROUND: The long-term effect of coil embolization therapy in HOCM patients is not well defined. METHODS: We evaluated 24 symptomatic HOCM patients in a single center who underwent coil embolization of the septal perforator artery(ies)...
August 11, 2016: Catheterization and Cardiovascular Interventions
Miyu Tajima, Nobuo Iguchi, Yuko Utanohara, Yukio Hiroi, Keitaro Mahara, Tatsunori Niwa, Morimasa Takayama, Tetsuya Sumiyoshi, Hitonobu Tomoike
BACKGROUND: Abnormalities of the endocardial subvalvular apparatus (SVA), which includes the papillary muscles directly attached to the mitral leaflet and left ventricular apical-basal muscle bundles, are occasionally identified in hypertrophic cardiomyopathy (HCM). Their associations with left ventricular outflow tract (LVOT) obstruction are unknown. METHODS: We retrospectively reviewed cardiac computed tomography image data sets of 107 consecutive patients with HCM [56 obstructive (HOCM) and 51 non-obstructive (HNOCM)] as well as 53 controls...
September 2016: Journal of Cardiovascular Computed Tomography
Yutaro Mukai, Kyoichi Wada, Mai Fujimoto, Kouichi Hosomi, Takeshi Kuwahara, Mitsutaka Takada
OBJECTIVE: The purpose of this study was to evaluate the long-term impact of therapeutic drug monitoring (TDM) services on the risk of hypoglycemia in cibenzoline therapy. In addition, we evaluated the impact of changes in clinical setting or patient background on the risk of hypoglycemia in patients receiving cibenzoline. METHODS: TDM services for cibenzoline have been performed at the Japan National Cerebral and Cardiovascular Center since March 1998. A case-control study was performed from September 2012 to February 2013, and the calculated risk of hypoglycemia associated with cibenzoline use was compared with data from our previous studies, which were performed ~ 15 years ago...
October 2016: International Journal of Clinical Pharmacology and Therapeutics
Janina Kitow, Anselm A Derda, Julia Beermann, Regalla Kumarswarmy, Angelika Pfanne, Jasmin Fendrich, Johan M Lorenzen, Ke Xiao, Udo Bavendiek, Johann Bauersachs, Thomas Thum
Hypertrophic cardiomyopathy (HCM) is a hereditary heart disease with a high risk for sudden cardiac death in young people. As a subtype, hypertrophic obstructive cardiomyopathy (HOCM) additionally has a left ventricular outflow gradient, showing stronger symptoms and requires a different treatment compared with hypertrophic nonobstructive cardiomyopathy (HNCM). In this study our aim was to investigate the regulation of mitochondrial and cardiac remodeling associated long noncoding RNAs (lncRNAs) in blood of patients affected with HOCM and HNCM...
September 1, 2016: American Journal of Physiology. Heart and Circulatory Physiology
Yousef Bader, Carey Kimmelstiel
Retrospective comparison of alcohol septal ablation with surgical myectomy suggests that although there is a greater reduction in LVOT gradient with surgical myectomy, symptom relief and survival are similar between the two treatment strategies. In patients who don't have an anatomic indication for surgical myectomy, alcohol septal ablation appears to be a safe and effective alternative. Patients with medication-refractory HOCM require a multi-disciplinary assessment, which is best performed at specialized treatment centers, to assess which therapy is best suited to treat them...
July 2016: Catheterization and Cardiovascular Interventions
Jaeouk Shin, Minsu Kim, Junsoo Lee, Sihun Kim, Myeonggun Kim, Hyunjung Hwang, Jeonggeun Moon, Mi-Seung Shin, Wook-Jin Chung
Hypertrophic obstructive cardiomyopathy (HOCM) patients with severe left ventricular outflow tract (LVOT) obstruction (those with a gradient of > 100 mm Hg) are at the highest risk of hemodynamic deterioration during pregnancy. Complications of HOCM include sudden cardiac death, heart failure, and arrhythmias. Physiological changes during pregnancy may induce these complications, affecting maternal and fetal health conditions. Therefore, close monitoring with appropriate management is essential for the well-being of both mother and fetus...
June 2016: Journal of Cardiovascular Ultrasound
Yun Liu, Yunhu Song, Ge Gao, Jun Ran, Wenjun Su, Haojie Li, Yajie Tang, Fujian Duan, Hansong Sun
The indications for a concomitant mitral valve (MV) procedure remain controversial for patients with hypertrophic obstructive cardiomyopathy (HOCM). According to previous studies, a concomitant MV surgery was required in 11-20% of inpatient operations. Thus, we aimed to study the outcomes of an extended Morrow procedure without a concomitant MV procedure for HOCM patients who had no intrinsic abnormalities of the MV apparatus. We retrospectively reviewed 232 consecutive HOCM patients who underwent extended Morrow procedures from January 2010 to October 2014...
2016: Scientific Reports
Yuichiro Maekawa, Keitaro Akita, Hikaru Tsuruta, Yoshitake Yamada, Kentaro Hayashida, Shinsuke Yuasa, Mitsushige Murata, Masahiro Jinzaki, Keiichi Fukuda
OBJECTIVE: In patients with hypertrophic obstructive cardiomyopathy (HOCM), left atrial (LA) volume measurement is very important to provide prognostic information. Recent studies demonstrated that multidetector CT (MDCT) is useful to assess the changes in LA volume. Our aim was to examine the utility of a follow-up cardiac MDCT for long-term evaluation of the effect of percutaneous transluminal septal myocardial ablation (PTSMA) on LA volume. METHODS: We studied a consecutive cohort of 20 patients with drug-refractory symptomatic HOCM after PTSMA...
2016: Open Heart
Angelos G Rigopoulos, Silke Daci, Barbara Pfeiffer, Konstadia Papadopoulou, Anna Neugebauer, Hubert Seggewiss
INTRODUCTION: Percutaneous alcohol septal ablation (PTSMA) is an established treatment for symptomatic patients with hypertrophic obstructive cardiomyopathy (HOCM). However, there is concern of a higher risk for ventricular tachyarrhythmias and sudden death due to the myocardial scar created after PTSMA. We investigated the possibility of increased ventricular arrhythmias and risk of sudden death after PTSMA in a subgroup of patients with an already implanted ICD. METHODS AND RESULTS: Between 2009 and 2012, 239 PTSMAs were performed in 212 patients with HOCM...
June 6, 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Thierry Fozing, Nayef Zouri, Oliver Adam, Cem Oezbek
A 44-year-old man, with a history of arterial hypertension, was referred with increasing shortness of breath due to a large pericardial effusion and imminent tamponade. Emergency ultrasound-guided pericardiocentesis resulted in the rapid withdrawal of 2760 cc of serous fluid. 3 hours later, the patient developed acute pulmonary oedema, which was successfully treated. Hypertrophic obstructive cardiomyopathy was later diagnosed and malignancy was excluded as a cause of the effusion. Clinicians performing pericardiocentesis need to be aware of pericardial decompression syndrome (PDS), a rare but serious complication...
2016: BMJ Case Reports
Lei Yao, Li Li, Xiong-Jun Lu, Yan-Ling Miao, Xiao-Ning Kang, Fu-Jian Duan
BACKGROUND: There has been limited data addressing outcomes of extensive septal myectomy in Chinese patients with hypertrophic obstructive cardiomyopathy (HOCM). In this study, the objective was to evaluate the clinical and echocardiographic outcomes of extensive septal myectomy in a relative large number of Chinese HOCM patients over long-term follow-up. METHODS: We retrospectively studied 139 consecutive HOCM patients (age 43 ± 15 years, 37 % male) who underwent extensive left ventricular septal myectomy...
2016: Cardiovascular Ultrasound
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