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https://www.readbyqxmd.com/read/29783236/clinical-aspects-of-gastropathy-development-in-patients-with-chronic-obstructive-pulmonary-disease
#1
Anna V Chetaikina, Helen Ye Sklyarova, Iryna V Shalko, Roman Ya Dutka
OBJECTIVE: Introduction: Chronic obstructive pulmonary disease (COPD) is a one of the main reasons of disability and mortality in the world. The essential attention is dedicated to the combination of COPD and erosive/ulcer defects with the haemorrhage risk factor. The aim was to compare gastric acidity and mucoid secretion in patients with chronic obstructive pulmonary disease of gastropathy development. PATIENTS AND METHODS: Materials and methods: 94 patients with gastroduodenal erosive and ulcerous defects combined with COPD were examined...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783230/comprehensive-patterns-of-comorbidity-copd-and-depression-aspects-of-treatment
#2
Natalia V Moisieieva, Liliya V Burya, Anna A Kapustianskaya, Iryna A Kolenko, Maria A Rumyantseva, Oleksii H Shumeiko
OBJECTIVE: Introduction: Data on the prevalence of psychopathological disorders in the exacerbation of chronic obstructive pulmonary disease (COPD) are very heterogeneous. COPD and depression have common predisposing factors. The aim: The aim of the research is to conduct a comprehensive assessment of the effect of paroxetine on the level of depressive disorders in the exacerbation of severe degree COPD in women. PATIENTS AND METHODS: Materials and methods: The study included patients with severe degree COPD and depressive disorder...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29782663/prospective-study-confirms-that-bronchiolitis-in-early-infancy-increases-the-risk-of-reduced-lung-function-at-10-13-years-of-age
#3
Riikka Riikonen, Eero Lauhkonen, Sari Törmänen, Katri Backman, Petri Koponen, Merja Helminen, Kirsi Nuolivirta, Matti Korppi
AIM: This study evaluated children hospitalised for bronchiolitis at less than six months of age to see if they had reduced lung function in early adolescence. METHODS: We have prospectively followed 166 children hospitalised for infant bronchiolitis in 2001-2004 at Tampere University Hospital, Finland. At 10-13 years of age, flow-volume spirometry was measured in 89 cases and 108 controls without infant bronchiolitis from the local population register. Parameters of flow-volume spirometry before and after bronchodilation were analysed...
May 21, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29782224/efficacy-and-safety-of-dupilumab-in-glucocorticoid-dependent-severe-asthma
#4
Klaus F Rabe, Parameswaran Nair, Guy Brusselle, Jorge F Maspero, Mario Castro, Lawrence Sher, Hongjie Zhu, Jennifer D Hamilton, Brian N Swanson, Asif Khan, Jingdong Chao, Heribert Staudinger, Gianluca Pirozzi, Christian Antoni, Nikhil Amin, Marcella Ruddy, Bolanle Akinlade, Neil M H Graham, Neil Stahl, George D Yancopoulos, Ariel Teper
Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. Its effectiveness in reducing oral glucocorticoid use in patients with severe asthma while maintaining asthma control is unknown. Methods We randomly assigned 210 patients with oral glucocorticoid-treated asthma to receive add-on dupilumab (at a dose of 300 mg) or placebo every 2 weeks for 24 weeks. After a glucocorticoid dose-adjustment period before randomization, glucocorticoid doses were adjusted in a downward trend from week 4 to week 20 and then maintained at a stable dose for 4 weeks...
May 21, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29782217/dupilumab-efficacy-and-safety-in-moderate-to-severe-uncontrolled-asthma
#5
Mario Castro, Jonathan Corren, Ian D Pavord, Jorge Maspero, Sally Wenzel, Klaus F Rabe, William W Busse, Linda Ford, Lawrence Sher, J Mark FitzGerald, Constance Katelaris, Yuji Tohda, Bingzhi Zhang, Heribert Staudinger, Gianluca Pirozzi, Nikhil Amin, Marcella Ruddy, Bolanle Akinlade, Asif Khan, Jingdong Chao, Renata Martincova, Neil M H Graham, Jennifer D Hamilton, Brian N Swanson, Neil Stahl, George D Yancopoulos, Ariel Teper
Background Dupilumab is a fully human anti-interleukin-4 receptor α monoclonal antibody that blocks both interleukin-4 and interleukin-13 signaling. We assessed its efficacy and safety in patients with uncontrolled asthma. Methods We randomly assigned 1902 patients 12 years of age or older with uncontrolled asthma in a 2:2:1:1 ratio to receive add-on subcutaneous dupilumab at a dose of 200 or 300 mg every 2 weeks or matched-volume placebos for 52 weeks. The primary end points were the annualized rate of severe asthma exacerbations and the absolute change from baseline to week 12 in the forced expiratory volume in 1 second (FEV1 ) before bronchodilator use in the overall trial population...
May 21, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29781588/smoking-in-systemic-sclerosis-a-longitudinal-european-scleroderma-trials-and-research-group-study
#6
Veronika K Jaeger, Gabriele Valentini, Eric Hachulla, Franco Cozzi, Oliver Distler, Paolo Airó, Laszlo Czirják, Yannick Allanore, Elise Siegert, Edoardo Rosato, Marco Matucci-Cerinic, Cristian Caimmi, Jörg Henes, Patricia E Carreira, Vanessa Smith, Francesco Del Galdo, Christopher P Denton, Susanne Ullman, Ellen De Langhe, Valeria Riccieri, Juan J Alegre-Sancho, Simona Rednic, Ulf Müller-Ladner, Ulrich A Walker
OBJECTIVES: Data on the role of tobacco exposure in systemic sclerosis (SSc) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations in the EUSTAR database. METHODS: Adult SSc patients with data on smoking history and a 12-24 months follow-up visit were included. Associations of severity and progression of organ involvement with smoking history and the comprehensive smoking index (CSI) were assessed using multivariable regression analyses...
May 21, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29779416/long-term-triple-therapy-de-escalation-to-indacaterol-glycopyrronium-in-copd-patients-sunset-a-randomized-double-blind-triple-dummy-clinical-trial
#7
Kenneth R Chapman, John R Hurst, Stefan-Marian Frent, Michael Larbig, Robert Fogel, Tadhg Guerin, Donald Banerji, Francesco Patalano, Pankaj Goyal, Pascal Pfister, Konstantinos Kostikas, Jadwiga A Wedzicha
RATIONALE: There are no studies on ICS withdrawal in patients on long-term triple therapy in the absence of frequent exacerbations. OBJECTIVE: To evaluate the efficacy and safety of the direct de-escalation from long-term triple therapy to indacaterol/glycopyrronium in non-frequently exacerbating COPD patients. METHODS: This 26-week, randomized, double-blind, triple-dummy study assessed the direct change from long-term triple therapy to indacaterol/glycopyrronium (110/50μg once daily) or continuation of triple therapy (tiotropium 18μg once daily plus combination of salmeterol/fluticasone propionate [50/500μg] twice daily) in non-frequently exacerbating patients with moderate-to-severe COPD...
May 20, 2018: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29779389/-prevalence-and-severity-of-chronic-parodontitis-and-oral-mucosal-lesions-in-chronic-obstructive-lung-disease
#8
Ágnes Bán, Zsolt Ferenc Németh, Adrienn Szauter, Szilvia Soós, Márta Balaskó
INTRODUCTION: Chronic parodontitis is a prevalent oral disease that may lead to the loss of teeth independently of caries. Some systemic diseases (e.g., diabetes mellitus, chronic renal failure) may aggravate chronic parodontitis. On the other hand, this oral disease may aggravate other systemic diseases. Earlier studies suggested a correlation between chronic parodontitis and very severe chronic obstructive pulmonary disease (COPD). AIM: The aim of our study was the investigation of the correlation between chronic parodontitis and chronic obstructive pulmonary disease...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29778658/marijuana-and-lung-disease
#9
REVIEW
Donald P Tashkin
As marijuana smoking prevalence increases in the U.S. concern regarding its potential risks to lung health has also risen, given the general similarity in the smoke contents between marijuana and tobacco. Most studies have found a significant association between marijuana smoking and chronic bronchitis symptoms after adjustment for tobacco. While reports are mixed regarding associations between marijuana smoking and lung function, none has shown a relationship to decrements in forced expired volume in 1 sec (FEV1) and few have found a relationship to a decreased ratio of FEV1 to forced vital capacity (FVC), possibly related to an association between marijuana and an increased FVC...
May 17, 2018: Chest
https://www.readbyqxmd.com/read/29776385/generation-of-ventilation-perfusion-ratio-map-in-surgical-patients-by-dual-energy-ct-after-xenon-inhalation-and-intravenous-contrast-media
#10
Kohei Aoki, Yotaro Izumi, Wataru Watanabe, Yuji Shimizu, Hisato Osada, Norinari Honda, Toshihide Itoh, Mitsuo Nakayama
BACKGROUND: While many studies have evaluated the change in lung volume before and after lung resection and correlated this with pulmonary function test results, there is very little evidence on the changes in ventilation perfusion ratio (V/Q) before versus after lung resection. In the present pilot study, we evaluated if V/Q mapping can be constructed using dual energy CT images. METHODS: Thirty-one lung cancer patients planned for pulmonary resection were included in this study...
May 18, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29775687/effects-of-bronchodilation-on-biomarkers-of-peripheral-airway-inflammation-in-copd
#11
Pierachille Santus, Dejan Radovanovic, Susanna Mascetti, Alessia Pauletti, Vincenzo Valenti, Marco Mantero, Alberto Papi, Marco Contoli
Peripheral airway inflammation and dysfunction are key elements in the pathogenesis of COPD. The exhaled alveolar fraction of nitric oxide (CANO) is an indirect biomarker of lung peripheral inflammation. We tested whether inhaled long-acting bronchodilators (LABA) can affect CANO and we evaluated correlations with lung mechanics in patients with COPD. Two-centre, randomised, double blind, crossover study including COPD patients with moderate-to-severe airflow obstruction. Following a pharmacological washout, multi-flow exhaled fraction of NO (FENO), plethysmography, lung diffusion (DLCO), single breath nitrogen washout test and dyspnoea were measured in a crossover manner at baseline and 30, 60 and 180 minutes following administration of salmeterol (Sal) or formoterol fumarate (FF)...
May 15, 2018: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29773689/risk-factors-for-lung-disease-progression-in-children-with-cystic-fibrosis
#12
Marieke van Horck, Kim van de Kant, Bjorn Winkens, Geertjan Wesseling, Vincent Gulmans, Han Hendriks, Chris van der Grinten, Quirijn Jӧbsis, Edward Dompeling
To identify potential risk factors for lung disease progression in children with cystic fibrosis (CF), we studied the longitudinal data of all children with CF (aged ≥5 years) registered in the Dutch CF Registry (2009-2014). Lung disease progression was expressed as a decline in lung function (FEV1 %pred) and the pulmonary exacerbation rate (PEx). Potential risk factors at baseline included: sex, age, best FEV1%pred, best forced vital capacity (FVC)%pred, genotype, BMI z-score, pancreatic insufficiency, medication use (proton pump inhibitors [PPI], prophylactic antibiotics, and inhaled corticosteroids), CF-related diabetes, allergic bronchopulmonary aspergillosis, and colonisation with Pseudomonas aeruginosa The data of 545 children were analysed...
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29772578/long-term-omalizumab-treatment-a-multicenter-real-life-5-year-trial
#13
Arzu Yorgancıoğlu, Ferda Öner Erkekol, Dilşad Mungan, Münevver Erdinç, Bilun Gemicioğlu, Zeynep Ferhan Özşeker, Papatya Bayrak Değirmenci, Sibel Naycı, Aykut Çilli, Füsun Erdenen, Cengiz Kırmaz, Dane Ediger, Arzu Didem Yalçın, Suna Büyüköztürk, Sami Öztürk, Mustafa Güleç, Sacide Rana Işık, Ali Fuat Kalyoncu, Özlem Göksel, Ömür Aydın, Yavuz Havlucu, İdilhan Baloğlu Ar, Ahmet Erdoğdu
BACKGROUND: Omalizumab has demonstrated therapeutic benefits both in controlled clinical trials and real-life studies. However, research concerning the long-term effects and tolerability of omalizumab is needed. The main objective of this study was to evaluate the effectiveness and tolerability of treatment with omalizumab for up to 5 years. METHODS: A multicenter, retrospective, chart-based study was carried out to compare documented exacerbations, hospitalizations, systemic steroid requirement, FEV1, and asthma control test (ACT) results during 1 year prior to omalizumab treatment versus at 1, 3, and 5 years of treatment...
May 17, 2018: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29771822/pulse-oximetry-and-arterial-oxygen-saturation-during-cardiopulmonary-exercise-testing
#14
Mona Ascha, Anirban Bhattacharyya, Jose A Ramos, Adriano R Tonelli
INTRODUCTION/PURPOSE: Peripheral capillary oxygen saturation (SpO2) is used as surrogate for arterial blood oxygen saturation. We studied the degree of discrepancy between SpO2 and arterial oxygen (SaO2) and identified parameters that may explain this difference. METHODS: We included patients who underwent cardiopulmonary exercise testing (CPET) at Cleveland Clinic. Pulse oximeters with forehead probes measured SpO2 and arterial blood gas (ABG) samples provided the SaO2 both at rest and peak exercise...
April 30, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29771599/clinical-characterization-of-children-with-resistant-airflow-obstruction-a-multicenter-study
#15
Sankaran Krishnan, Allen J Dozor, Leonard Bacharier, Jason E Lang, Charles G Irvin, David Kaminsky, Harold J Farber, Lynn Gerald, Mark Brown, Janet T Holbrook, Robert A Wise, Julie Ryu, Sonali Bose, Yasin Razan, Joy Saams, Robert J Henderson, William G Teague
OBJECTIVE: To characterize a cohort of children with airflow limitation resistant to bronchodilator (BD) therapy. METHODS: Pulmonary function tests performed in children 6-17 years of age at 15 centers in a clinical research consortium were screened for resistant airflow limitation, defined as a post-BD FEV1 and/or an FEV1 /FVC less than the lower limits of normal. Demographic and clinical data were analyzed for associations with pulmonary function. RESULTS: 582 children were identified...
May 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29771038/-efficacy-of-standardized-sublingual-immunotherapy-of-allergic-asthma-with-rhinitis-in-children-between-different-age-groups
#16
S J Wu, S Chen, B Chen, L Wang, X Zeng
Objective: The aim of this study is to evaluate the efficacy of standardized sublingual immunotherapy of allergic asthma with rhinitis in children between two different age groups. Method: Retrospective analysis of 250 patients with allergic asthma and rhinitis who received SLIT treatment. According to the age divided into younger children group (aged 3-6 years, 128 patients) and older children group (aged 7-13 years, 122 patients). Evaluate the asthma daytime, nocturnal symptom, medication score, VAS score and pulmonary function FEV1, PEF% level and rhinitis symptom and medication score before and after treatment of two groups of children...
May 20, 2017: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/29770791/effects-of-laparoscopic-and-conventional-methods-on-lung-functions-in-colorectal-surgery
#17
Sebahattin Celik, Eyüp M Yılmaz
BACKGROUND We aimed to compare the lung functions, complication rates, and durations of the hospital and intensive care unit stays of patients who had undergone laparoscopic colorectal resection and open colorectal resection. MATERIAL AND METHODS In this study, data were collected prospectively and then evaluated retrospectively. The study was carried out between January 2015 and November 2016 in 2 university hospitals. Pulmonary function tests (PFT) and chest radiography were performed in all patients preoperatively...
May 17, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29768509/aging-related-trajectories-of-lung-function-in-the-general-population-the-doetinchem-cohort-study
#18
Sandra H van Oostrom, Peter M Engelfriet, W M Monique Verschuren, Maarten Schipper, Inge M Wouters, Marike Boezen, Henriëtte A Smit, Huib A M Kerstjens, H Susan J Picavet
The objective of this study was to explore trajectories of lung function decline with age in the general population, and to study the effect of sociodemographic and life style related risk factors, in particular smoking and BMI. For this purpose, we used data from the Doetinchem Cohort Study (DCS) of men and women, selected randomly from the general population and aged 20-59 years at inclusion in 1987-1991, and followed until the present. Participants in the DCS are assessed every five years. Spirometry has been performed as part of this assessment from 1994 onwards...
2018: PloS One
https://www.readbyqxmd.com/read/29766487/inhaled-corticosteroids-for-bronchiectasis
#19
REVIEW
Nitin Kapur, Helen L Petsky, Scott Bell, John Kolbe, Anne B Chang
BACKGROUND: Bronchiectasis is being increasingly diagnosed and recognised as an important contributor to chronic lung disease in both adults and children in high- and low-income countries. It is characterised by irreversible dilatation of airways and is generally associated with airway inflammation and chronic bacterial infection. Medical management largely aims to reduce morbidity by controlling the symptoms, reduce exacerbation frequency, improve quality of life and prevent the progression of bronchiectasis...
May 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29765337/plethysmographic-loops-a-window-on-the-lung-pathophysiology-of-copd-patients
#20
Dejan Radovanovic, Matteo Pecchiari, Fabio Pirracchio, Camilla Zilianti, Edgardo D'Angelo, Pierachille Santus
Plethysmographic alveolar pressure-flow ( P alv - F ) loops contain potentially relevant information about the pathophysiology of chronic obstructive pulmonary disease (COPD), but no quantitative analysis of these loops during spontaneous breathing has ever been performed. The area of the loop's inspiratory ( A ins ) and expiratory portion ( A exp ), and the difference between the end-expiratory and end-inspiratory alveolar pressure (Δ P alv ) were measured in 20 young, 20 elderly healthy subjects, and 130 stable COPD patients...
2018: Frontiers in Physiology
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