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clinical thyroid function test

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https://www.readbyqxmd.com/read/28913004/hypermetabolic-thyroid-incidentaloma-on-positron-emission-tomography-review-of-laboratory-radiologic-and-pathologic-characteristics
#1
Mehrdad Bakhshayesh Karam, Abtin Doroudinia, Farzaneh Joukar, Kobra Nadi, Atosa Dorudinia, Payam Mehrian, Abbas Yousefikoma
INTRODUCTION: Incidental hypermetabolic thyroid lesions on Positron Emission Tomography have significant clinical value and may harbor malignancy. In this study we evaluated laboratory, radiologic, and pathologic characteristics of incidental hypermetabolic thyroid lesions. MATERIALS AND METHODS: We evaluated 18 patients prospectively with various malignancies and hypermetabolic thyroid incidentaloma. The thyroid function tests, ultrasound assessment, and guided FNA biopsy were performed on all cases...
2017: Journal of Thyroid Research
https://www.readbyqxmd.com/read/28912821/thyrotoxicosis-and-choledocholithiasis-masquerading-as-thyroid-storm
#2
Christian L Horn, Patricia A Short
A 26-year-old female, thirteen months postpartum, presented to the emergency department for four weeks of epigastric abdominal pain, pruritus, new onset jaundice, and 11.3 kgs (25 lbs) unintentional weight loss. On examination, she was afebrile, tachycardic, alert, and oriented and had jaundice with scleral icterus. Labs were significant for undetectable TSH, FT4 that was too high to measure, and elevated total bilirubin, direct bilirubin, alkaline phosphatase, and transaminases. Abdominal ultrasound revealed cholelithiasis without biliary ductal dilation...
2017: Case Reports in Medicine
https://www.readbyqxmd.com/read/28910997/paediatric-nuclear-medicine-imaging
#3
Lorenzo Biassoni, Marina Easty
Background: Nuclear medicine imaging explores tissue viability and function by using radiotracers that are taken up at cellular level with different mechanism. This imaging technique can also be used to assess blood flow and transit through tubular organs. Nuclear medicine imaging has been used in paediatrics for decades and this field is continuously evolving. Sources of data: The data presented comes from clinical experience and some milestone papers on the subject...
September 1, 2017: British Medical Bulletin
https://www.readbyqxmd.com/read/28899347/case-report-of-hyperglycemic-nonketotic-chorea-with-rapid-radiological-resolution
#4
H M M T B Herath, S P Pahalagamage, Sunethra Senanayake
BACKGROUND: Hemichorea is a rare manifestation of nonketotic hyperglycemia that usually affects elderly Asian women with poor glycemic control. Non-contrast computerized Tomography and T1- weighted Magnetic Resonance Imaging shows characteristic hyperintense basal ganglia lesions. CASE PRESENTATION: A Fifty-seven year old Sri Lankan female presented with a two-day history of right upper limb chorea. She had been diagnosed with diabetes mellitus one year ago, but was not on any treatment and did not have any micro vascular or macro vascular complications...
September 12, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28893031/estimation-of-salivary-parameters-among-autoimmune-thyroiditis-patients
#5
Yasmeen Amthul Syed, Bh Satheesh Reddy, T K Ramamurthy, Kavitha Rajendra, Narendra Kumar Nerella, Meenakshi Krishnan, M V Ramesh, Rezwana Begum Mohammed
INTRODUCTION: Saliva is a complex secretion that protects and lubricates the oral cavity. Various systemic diseases and their treatment alter the salivary gland function; one such disease is Autoimmune Thyroid Disease (AITD). AITD has been postulated to exert its hormonal influence on the salivary glands, leading to reduced salivary output. There's a paucity of literature, verifying the stated conjunction in human subjects. AIM: The aim was to investigate the salivary profile in AITD patients and its comparison with controls...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892954/serum-free-t3-to-free-t4-ratio-as-a-useful-indicator-for-differentiating-destruction-induced-thyrotoxicosis-from-graves-disease
#6
Suman Baral, Pradeep Krishna Shrestha, Vivek Pant
INTRODUCTION: Thyrotoxicosis is a common disease encountered in Endocrine Outpatient Department (OPD). Two common causes of thyrotoxicosis are Destruction Induced Thyrotoxicosis (DIT) and Graves' Disease (GD). Differentiating DIT and GD based on clinical findings, is often not possible due to nonspecific symptoms. Thyroid scan is considered most reliable method for differentiating DIT and GD. AIM: To differentiate DIT and GD using the ratio of free triiodothyronine (fT3) and free thyroxine (fT4) thus avoiding thyroid technetium scan which is expensive and not accessible in developing countries like Nepal...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28885368/successful-management-of-octreotide-insensitive-thyrotropin-secreting-pituitary-adenoma-with-bromocriptine-and-surgery-a-case-report-and-literature-review
#7
Chengxian Yang, Huanwen Wu, Jing Wang, Mingming Hu, Xiaoping Xing, Xinjie Bao, Renzhi Wang
RATIONALE: Case reports concerning the value of dopamine agonists in the treatment of patients with thyrotropin-secreting pituitary adenoma (TSHoma) are limited. Herein, we present a rare case of octreotide-insensitive TSHoma responding to bromocriptine therapy. PATIENT CONCERNS: A 45-year-old Chinese man was admitted to Peking Union Medical College Hospital with marked clinical manifestations of hyperthyroidism. DIAGNOSES: Thyroid function tests demonstrated elevated concentrations of free thyroid hormones in the presence of normal thyrotropin...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28872489/a-case-of-pure-red-cell-aplasia-during-nivolumab-therapy-for-cardiac-metastatic-melanoma
#8
Akihiko Yuki, Tatsuya Takenouchi, Sumiko Takatsuka, Takuro Ishiguro
Nivolumab is an antibody against programmed cell death 1 and functions as an immune checkpoint inhibitor for various malignancies, including unresectable melanomas. Nivolumab causes several immune-related adverse events, which typically include skin rash, pneumonitis, thyroid dysfunction, hepatitis, and colitis; in rare cases, anemia may be present. There are several reports of autoimmune hemolytic anemia that has developed in response to nivolumab; however, there are few reports of pure red cell aplasia (PRCA)...
September 1, 2017: Melanoma Research
https://www.readbyqxmd.com/read/28860961/case-report-a-toddler-with-anasarca-caused-by-congenital-nephrotic-syndrome
#9
Tumelo M Satekge, Olivia Kiabilua, Gertruida van Biljon, Komala Pillay, Tahir S Pillay
Congenital nephrotic syndrome is a rare inherited disorder arising from defects in the proteins of the cells in the glomerular basement membrane and develops either in utero or at birth. The clinical presentation is the result of massive protein loss in the urine with associated compensatory mechanisms. Here we present a clinical case of a female toddler with a history of anasarca (severe generalised edema) from birth and who presents with the classical biochemical laboratory findings of nephrotic syndrome, together with the more pronounced features that arise from protein loss including abnormal thyroid function testing and a marked hypercholesterolaemia...
May 2017: EJIFCC
https://www.readbyqxmd.com/read/28855267/therapy-of-endocrine-disease-t4-t3-combination-therapy-is-there-a-true-effect
#10
Wilmar M Wiersinga
5-10% of hypothyroid patients on T4 replacement have persistent symptoms, despite normal TSH levels. T4+T3 combination therapy provided no better outcomes according to a meta-analysis of 11 randomized clinical trials comparing T4 monotherapy with T4+T3 combination therapy. This review evaluates recent developments in the field of T4+T3 therapy . T4 monotherapy is associated with higher serum FT4 and lower serum FT3 and FT3/FT4 ratio's than in healthy subjects. T4+T3 combination therapy may mimic more closely thyroid function tests of healthy subjects, but it has not been demonstrated that relatively low serum FT3 or FT3/FT4 ratio's are linked to persistent symptoms...
August 30, 2017: European Journal of Endocrinology
https://www.readbyqxmd.com/read/28835757/avoiding-misdiagnosis-due-to-antibody-interference-with-serum-free-thyroxin
#11
Pilar I Beato-Víbora, S Alejo-González
INTRODUCTION: Interfering antibodies are capable of causing potentially misleading results in automated thyroid hormone immunoassays. CASE PRESENTATION: We report the case of a 46- year-old female patient with autoimmune hypothyroidism in chronic replacement treatment with levothyroxine who was presented 8 years after diagnosis with a thyroid function test showing an increased level of TSH and a very high level of FT4. Interference in the laboratory serum free thyroxin (FT4) test was suspected, due to the lack of symptoms of hyperthyroidism and a different immunoassay platform confirmed a low FT4 result...
January 2017: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28835054/-clinical-and-pathological-differences-between-papillary-thyroid-carcinoma-with-graves-disease-and-papillary-thyroid-carcinoma-with-hashimoto-s-thyroiditis
#12
D D Xu, Y Lun, X Liu, H Jiang, J B Song, Z Q Duan, S J Xin, J Zhang
Objective: To explore the clinical and pathological differences between papillary thyroid carcinoma (PTC) with Graves' disease (GD) and PTC with Hashimoto's thyroiditis (HT). Methods: A total of 33 PTC patients with GD and 132 PTC patients with HT in the First Affiliated Hospital of China Medical University from January 2009 to December 2015 were enrolled. The clinical and histopathological data were analyzed. Results: The average serum concentration of thyroid stimulating hormone (TSH) of PTCs with GD was significantly lower than PTCs with HT [0...
August 22, 2017: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28816534/seven-familial-dysalbuminemic-hyperthyroxinemia-cases-in-three-unrelated-japanese-families-and-high-performance-liquid-chromatography-analysis-of-the-thyroxine-binding-profile
#13
Hidekazu Nagano, Yoshinori Nakagawa, Naofumi Ishikawa, Yuya Watanabe, Yui Miyabayashi, Akitoshi Nakayama, Masanori Fujimoto, Eri Komai, Akina Shiga, Ai Tamura, Takashi Kono, Tomoko Takiguchi, Seiichiro Higuchi, Ikki Sakuma, Naoko Hashimoto, Sawako Suzuki, Hisashi Koide, Kotaro Yokote, Tomoaki Tanaka
OBJECTIVE: Familial dysalbuminemic hyperthyroxinemia (FDH) is caused by abnormal human serum albumin (HSA) with an increased thyroxine (T4) affinity leading to euthyroid hyperthyroxinemia. One- and two-step immunoassay of serum samples from FDH patients (e.g., Japanese patients) with the HSA R218P mutation can yield false-positive free thyroxine (FT4) results. Therefore, it is difficult to distinguish FDH from syndrome of inappropriate secretion of thyroid-stimulating hormone (e.g., syndrome of resistance to thyroid hormone, thyroid-stimulating hormone [TSH]-producing pituitary adenoma), even when multiple assays are used...
August 17, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28771610/the-impact-of-thyroid-hormones-on-patients-with-hepatocellular-carcinoma
#14
Matthias Pinter, Lukas Haupt, Florian Hucke, Simona Bota, Theresa Bucsics, Michael Trauner, Markus Peck-Radosavljevic, Wolfgang Sieghart
BACKGROUND & AIMS: Hypothyroidism has recently been proposed as predisposing factor for HCC development. However, the role of thyroid hormones (TH) in established HCC is largely unclear. We investigated the impact of TH on clinical characteristics and prognosis of HCC patients. METHODS: Of 838 patients diagnosed with nonsurgical HCC at the Division of Gastroenterology and Hepatology/Medical University of Vienna between 1992 and 2012, 667 patients fulfilled the inclusion criteria...
2017: PloS One
https://www.readbyqxmd.com/read/28753406/association-of-established-thyroid-stimulating-hormone-and-free-thyroxine-genetic-variants-with-hashimoto-s-thyroiditis
#15
Luka Brčić, Sanda Gračan, Ana Barić, Ivana Gunjača, Vesela Torlak Lovrić, Ivana Kolčić, Tatijana Zemunik, Ozren Polašek, Maja Barbalić, Ante Punda, Vesna Boraska Perica
Hashimoto's thyroiditis (HT), the most frequent autoimmune thyroid disease (AITD), is characterized by chronic inflammation of the thyroid gland that usually results in hypothyroidism. Thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels are used as clinical determinants of thyroid function. The main aim of this study was to explore the association of established TSH and FT4 genetic variants with HT. We performed a case-control analysis using 23 genetic markers in 200 HT patients and 304 controls...
August 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28749399/re-establishment-of-normal-radioactive-iodine-uptake-reference-range-in-the-era-of-universal-salt-iodization-in-the-indian-population
#16
Sanjana Ballal, Ramya Soundararajan, Chandrasekhar Bal
BACKGROUND & OBJECTIVES: The reference radioactive iodine uptake (RAIU) values established in the 1970s in the era of widespread iodine deficiency were relatively high. Now, after four decades of successful Universal Salt Iodization (USI) programme in India, there is a need to re-establish these reference ranges. The present study was aimed to quantify the two-hour and 24-h RAIU values in iodine sufficient euthyroid individuals and validate the results in Graves' and Hashimoto's thyroiditis patients...
March 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28745667/-prevention-and-correction-of-cognitive-dysfunction-after-general-anesthesia
#17
A Yu Novikov, V A Kovalev, N V Vinichuk, Yu A Chernyh, I E Golub, L V Sorokina
AIM: To evaluate clinical efficacy of intraoperative use of cytoflavin in the prevention and correction of cognitive functions in surgical patients with no history of neurological and psychosomatic disorders. MATERIAL AND METHODS: The study included 60 female patients who underwent surgery on the thyroid gland. Patients were stratified into two equal groups matched for main indices. Patients of the main group received infusions of cytoflavin (20 ml in 200 ml of 5% glucose solution)...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28742507/severe-neurological-abnormalities-in-a-young-boy-with-impaired-thyroid-hormone-sensitivity-due-to-a-novel-mutation-in-the-mct8-gene
#18
Teresa Rego, Carmen Gomez Lado, Paloma Cabanas Rodríguez, Francisco Sousa Santos, Francisco Barros Angueira, Lidia Castro-Feijóo, Jesús Barreiro Conde, Manuel Castro-Gago
Monocarboxylate transporter 8 (MCT8) is an active and specific thyroid hormone transporter into neurons. MCT8 mutations cause an X-linked condition known as Allan-Herndon-Dudley syndrome and are characterized by impaired psychomotor development and typical abnormal thyroid function. We describe a 10-year-old boy with severe cognitive disability, axial hypotonia, spastic quadriplegia and sporadic dyskinetic episodes. He initially presented with thyroid dysfunction (high FT3, low rT3, low FT4 and normal TSH) and generalized retardation of the cerebral and cerebellar myelination in brain magnetic resonance imaging...
April 2017: Hormones: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28732825/heterogeneity-of-lung-disease-associated-with-nk2-homeobox-1-mutations
#19
Elodie Nattes, Stephanie Lejeune, Ania Carsin, Raphael Borie, Isabelle Gibertini, Juan Balinotti, Nadia Nathan, Sylvain Marchand-Adam, Caroline Thumerelle, Brigitte Fauroux, Emmanuelle Bosdure, Veronique Houdouin, Celine Delestrain, MaleK Louha, Remy Couderc, Alix De Becdelievre, Pascale Fanen, Benoit Funalot, Bruno Crestani, Antoine Deschildre, Jean-Christophe Dubus, Ralph Epaud
We retrospectively studied the clinical presentation, treatment modalities and outcome in 16 patients with heterozygous NKX2-1 mutation associated with chronic lung disease. Twelve different NKX2-1 mutations, including 4 novel mutations, were identified in the 16 patients. Nine patients presented with brain-lung-thyroid syndrome, 3 had neurological and lung symptoms and 4 had only pulmonary symptoms. Ten patients had neonatal respiratory distress, and 6 of them developed infiltrative lung disease (ILD). The other patients were diagnosed with ILD in childhood (n = 3) or in adulthood (n = 3)...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28723963/impact-of-thyroid-function-abnormalities-on-reproductive-hormones-during-menstrual-cycle-in-premenopausal-hiv-infected-females-at-nauth-nnewi-nigeria
#20
Nkiruka Rose Ukibe, Solomon Nwabueze Ukibe, Obiageli Fidelia Emelumadu, Chinedum Charles Onyenekwe, Joseph Eberendu Ahaneku, Anthony Osita Igwegbe, Ifeoma Nwamaka Monago, Amobi Linus Ilika
BACKGROUND: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria. METHODS: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi...
2017: PloS One
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