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clinical thyroid function test

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https://www.readbyqxmd.com/read/29155897/advances-in-applied-homeostatic-modelling-of-the-relationship-between-thyrotropin-and-free-thyroxine
#1
Rudolf Hoermann, John Edward Maurice Midgley, Rolf Larisch, Johannes Wolfgang Christian Dietrich
INTRODUCTION: The relationship between pituitary TSH and thyroid hormones is central to our understanding of thyroid physiology and thyroid function testing. Here, we generated distribution patterns by using validated tools of thyroid modelling. METHODS: We simulated patterns of individual set points under various conditions, based on a homeostatic model of thyroid feedback control. These were compared with observed data points derived from clinical trials. RESULTS: A random mix of individual set points was reconstructed by simulative modelling with defined structural parameters...
2017: PloS One
https://www.readbyqxmd.com/read/29145283/the-relationship-between-rassf1a-promoter-methylation-and-thyroid-carcinoma-a-meta-analysis-of-14-articles-and-a-bioinformatics-of-2-databases-prisma
#2
Heng Niu, Jingyu Yang, Kunxian Yang, Yingze Huang
BACKGROUND: DNA promoter methylation can suppresses gene expression and shows an important role in the biological functions of Ras association domain family 1A (RASSF1A). Many studies have performed to elucidate the role of RASSF1A promoter methylation in thyroid carcinoma, while the results were conflicting and heterogeneous. Here, we analyzed the data of databases to determine the relationship between RASSF1A promoter methylation and thyroid carcinoma. METHODS: We used the data from 14 cancer-normal studies and Gene Expression Omnibus (GEO) database to analyze RASSF1A promoter methylation in thyroid carcinoma susceptibility...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144890/comprehensive-analysis-of-patients-with-neuromyelitis-optica-spectrum-disorder-nmosd-combined-with-chronic-hepatitis-b-chb-infection-and-seropositive-for-anti-aquaporin-4-antibody
#3
Jia Liu, Li Xu, Zhuo-Lin Chen, Min Li, Huan Yi, Fu-Hua Peng
Previous research indicated the association between hepatitis B virus (HBV) infection/vaccination and the onset of demyelinating diseases. However, most of these studies were single case reports, and comprehensive data are still scarce. Here we present a comprehensive analysis of 10 patients with neuromyelitis optica spectrum disorder (NMOSD) combined with chronic hepatitis B (CHB) infection and seropositive for anti-aquaporin-4 antibody (AQP4-Ab). Demographic, clinical, laboratory, neuroimaging, outcome, and follow-up data of the 10 patients were retrospectively analyzed...
November 16, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29137336/percutaneous-laser-ablation-for-benign-thyroid-nodules-a-meta-analysis
#4
Wei Fan Sui, Jian Yun Li, Jian Hua Fu
Purpose: To evaluate percutaneous laser ablation in treating benign thyroid nodules, we conducted a meta-analysis based on summarizing existing researches. Materials and Methods: A literature search for clinical trial was performed in PubMed, Cochrane Library and Excerpt Medica Database. The qualities of included studies were evaluated. We calculated the indexes with mean difference. Heterogeneity and publication bias were tested and explored. We performed subgroup analyses and sensitivity analysis further...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133077/-chronic-kidney-failure-and-biotin-a-combination-inducing-unusual-results-in-thyroid-and-parathyroid-investigations-report-of-2-cases
#5
Miora Koloina Ranaivosoa, Sébastien Ganel, Arnaud Agin, Sarah Romain, Xavier Parent, Nathalie Reix
In clinical chemistry, many immunoassays apply biotin and streptavidin in the assay principle. Presence of high levels of biotin in patient samples can produce negative or positive interference depending on the assay format. In this study, we describe 2 clinical cases with chronic kidney failure and with unusual thyroid and parathyroid function test results due to biotin interference. We studied the impact of biotin levels on thyroid stimulating hormone (TSH), free thyroxine (T4L) and parathormone (PTH) results with a pool of sera loaded with several concentrations of biotin...
November 10, 2017: Néphrologie & Thérapeutique
https://www.readbyqxmd.com/read/29108325/ratio-of-positive-lymph-nodes-the-prognostic-value-in-stage-iv-thyroid-cancer
#6
Tingyin Jiang, Chunling Huang, Yuan Xu, Yingrui Su, Guanjie Zhang, Long Xie, Liqun Huang, Shuchun You, Jinshun Zha
To assess the prognostic value of lymph node ratio (LNR) in patients with stage IV thyroid cancer based on the Surveillance, Epidemiology, and End Results (SEER) database. A total of 4,940 eligible patients were included for the analysis. Kaplan-Meier survival analysis and Cox proportional hazard regression were used to reveal the effect of LNR on overall survival (OS) and disease specific survival (DSS). The optimal cut-off value of LNR for predicting OS and DSS was determined by the time-dependent Receiver Operating Characteristic analysis...
October 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29105255/analysis-of-current-thyroid-function-test-ordering-practices
#7
Joseph K Kluesner, Darrick J Beckman, Joshua M Tate, Alexis A Beauvais, Maria I Kravchenko, Jana L Wardian, Sky D Graybill, Jeffrey A Colburn, Irene Folaron, Mark W True
RATIONALE: Current guidelines recommend thyroid stimulating hormone (TSH) alone as the best test to detect and monitor thyroid dysfunction, yet free thyroxine (FT4) and free triiodothyronine (FT3) are commonly ordered when not clinically indicated. Excessive testing can lead to added economic burden in an era of rising healthcare costs, while rarely contributing to the evaluation or management of thyroid disease. OBJECTIVE: To evaluate our institution's practice in ordering thyroid function tests (TFTs) and to identify strategies to reduce inappropriate FT4 and FT3 testing...
November 3, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29098964/misdiagnosis-of-graves-hyperthyroidism-due-to-therapeutic-biotin-intervention
#8
Yentl De Roeck, Eva Philipse, Theodorus B Twickler, Luc Van Gaal
BACKGROUND: Lately, high dose of biotin is often given orally to patients with a primary progressive multiple sclerosis (PPMS). However, the molecule biotin is also a principle compound in various analytic immunoassays. CLINICAL CASE: An asymptomatic 60-year-old woman with PPMS on high dose of biotin therapy (3 × 100 mg/d) displayed abnormal thyroid function tests (TSH 0.02 mU/l, fT4 > 103 pmol/l, and fT3 > 46 pmol/l). TSH was determined by a homogeneous sandwich chemiluminescent immunoassay and fT4 and fT3 were both determined by a homogeneous, sequential, chemiluminescent immunoassay...
November 3, 2017: Acta Clinica Belgica
https://www.readbyqxmd.com/read/29098662/deregulation-of-the-growth-hormone-insulin-like-growth-factor-1-axis-in-adults-with-cystic-fibrosis
#9
C Pascucci, R V De Biase, D Savi, S Quattrucci, A M Isidori, C Lubrano, L Gnessi, A Lenzi
PURPOSE: Patients with cystic fibrosis (CF) present with signs and symptoms that overlap with those of adult growth hormone deficiency (GHD) syndrome: loss of muscle mass, bone fragility and lower stress tolerance. In literature, the prevalence of GHD in pediatric CF patients is higher than general population, but these studies have been performed on children with growth delay. To our knowledge, there are no studies on adult patients. The aim of this paper is to evaluate GH-IGF1 axis in an adult CF population...
November 2, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29094880/disorders-of-puberty-an-approach-to-diagnosis-and-management
#10
David A Klein, Jill E Emerick, Jillian E Sylvester, Karen S Vogt
Disorders of puberty can profoundly impact physical and psychosocial well-being. Precocious puberty is pubertal onset before eight years of age in girls and before nine years of age in boys. Patients with early isolated pubertal changes, prepubertal linear growth, and no worrisome neurologic symptoms typically have a benign pattern of development and should be monitored in the appropriate clinical context. Among patients with true precocious puberty, or full activation of the hypothalamic-pituitary-gonadal axis, most girls have an idiopathic etiology, whereas it is commonly due to identifiable pathology on imaging in boys...
November 1, 2017: American Family Physician
https://www.readbyqxmd.com/read/29084189/-multiorgan-malfunction-after-fontan-operation-in-adult-patients
#11
Monika Smaś-Suska, Paweł Iwaszczuk, Beata Róg, Piotr Weryński, Maria Olszowska, Piotr Podolec, Lidia Tomkiewicz-Pająk
Although 85% of patients with univentricular heart after Fontan procedure survive twenty years after operation, the procedure alone seems to be an inadequate treatment as a permanent clinical solution. Patients with a "Fontan physiology" additionally have to face a various extra-cardiac complications, including thyroid, liver and kidney dysfunction, which are not only potentially life-threatening, but also can potentiate the circulatory insufficiency. AIM: The aim of the study was to assess a multiorgan dysfunction in adult patients after Fontan operation in long term follow-up and compare to healthy controls...
October 23, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29069456/thyroid-state-regulates-gene-expression-in-human-whole-blood
#12
Elske T Massolt, Marcel E Meima, Sigrid M A Swagemakers, Selmar Leeuwenburgh, Mirjam C G M van den Hout-van Vroonhoven, Giulia Brigante, Boen L R Kam, Peter J van der Spek, Wilfred F J van IJcken, Theo J Visser, Robin P Peeters, W Edward Visser
Context: Despite the well-recognized clinical features due to insufficient or excessive thyroid hormone (TH) levels in humans, it is largely unknown which genes are regulated by TH in human tissues. Objective: To study the effect of TH on human gene expression profiles in whole blood, mainly consisting of TRα-expressing cells. Methods: We performed next-generation RNA sequencing on whole blood samples from 8 athyroid patients (4 females) on and after 4 weeks off levothyroxine replacement...
October 23, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29067056/mean-platelet-volume-in-graves-disease-a-sign-of-hypermetabolism-rather-than-autoimmunity
#13
Gulay Simsek Bagir, Filiz Eksi Haydardedeoglu, Okan Sefa Bakiner, Emre Bozkirli, Melek Eda Ertorer
OBJECTIVE: To evaluate the impact of mean platelet volume (MPV) on predicting disease course among patients with Graves' disease (GD). METHODS: This retrospective study was performed between 2013-2016 at the Outpatient Endocrinology Clinic of Baskent University Faculty of Medicine, Adana hospital on 65 patients with GD. Among participants, 30 cases experienced thyrotoxicosis again during the first six months after discontinuing anti-thyroid drug (ATD) sessions that had been carried out for at least 12 months prior to stopping (Relapse group)...
July 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29059662/-euthyroid-sick-syndrome-an-important-clinical-problem
#14
Robert Krysiak, Agnieszka Kędzia, Karolina Kowalcze, Bogusław Okopień
Despite absence of thyroid disease, patients with non-thyroidal illness frequently have changes in serum thyroid hormone measurements that may suggest thyroid dysfunction. These abnormalities include low serum triiodothyronine, high reverse triiodothyronine and usually normal or inappropriately low thyrotropin and thyroxine levels. The degree of thyroid function impairment correlates with disease severity and low levels of thyroid hormones, particularly thyroxine, predict a poor prognosis. Considerable controversy exists on whether the fall in thyroid hormone levels is adaptive and simply a normal, physiologic response to conserve energy, or whether it is maladaptive and requires treatment...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29045188/rapid-evolution-of-thyroid-dysfunction-in-patients-treated-with-nivolumab
#15
Grenye O'Malley, Hanna J Lee, Samir Parekh, Matthew D Galsky, Cardinale B Smith, Philip Friedlander, Robert T Yanagisawa, Emily J Gallagher
OBJECTIVE: To describe the evolution of thyroid dysfunction in a series of patients with cancer treated with the immune checkpoint inhibitor anti-programmed cell death protein-1 (PD-1) monoclonal antibody, nivolumab. METHODS: Cases of thyroid dysfunction after initiation of checkpoint inhibitor treatment were identified from the Division of Endocrinology clinical practice at Mount Sinai Hospital, New York from April 2016 to February 2017. Charts were reviewed to identify patients treated with nivolumab with new onset of thyroid dysfunction...
October 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29026419/effect-of-vitamin-d-deficiency-treatment-on-thyroid-function-and-autoimmunity-markers-in-hashimoto-s-thyroiditis-a-double-blind-randomized-placebo-controlled-clinical-trial
#16
Parichehr Vahabi Anaraki, Ashraf Aminorroaya, Massoud Amini, Fatemeh Momeni, Awat Feizi, Bijan Iraj, Azamosadat Tabatabaei
BACKGROUND: The link between autoimmune thyroid diseases and Vitamin D deficiency has been reported. However, there are controversies in this regard. We conducted a double-blind randomized placebo-controlled clinical trial to investigate the effect of Vitamin D deficiency treatment on thyroid function and autoimmunity marker (thyroid peroxidase antibody [TPO-Ab]) in patients with Hashimoto's thyroiditis. MATERIALS AND METHODS: Fifty-six patients with Hashimoto's thyroiditis and Vitamin D deficiency (25-hydroxyvitamin D level ≤20 ng/mL) were randomly allocated into two groups to receive Vitamin D (50000 IU/week, orally) or placebo for 12 weeks, as Vitamin D-treated (n = 30) and control (n = 26) groups, respectively...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29024619/korean-pediatric-reference-intervals-for-ft4-tsh-and-tpo-ab-and-the-prevalence-of-thyroid-dysfunction-a-population-based-study
#17
Han Hyuk Lim
BACKGROUND: The appropriate age-related reference intervals for thyroid-stimulating hormone (TSH) and free thyroxine (FT4) are important in interpreting the results of thyroid function tests in children and adolescents. However, these reference intervals are scanty. This study aimed to establish the reference intervals for FT4, TSH, and thyroid peroxidase antibody (TPO Ab), and identify the epidemiological prevalence of thyroid dysfunction in a Korean pediatric population. METHODS: The data from a sample of 2042 children and adolescents aged 10-18years who underwent a nationwide Korean representative sampling and cross-sectional survey with blood collection for a thyroid function test using an electrochemiluminescence immunoassay were evaluated...
October 9, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28994881/povidone-iodine-pleurodesis-for-refractory-congenital-chylothorax-a-review-of-literature
#18
Nadia Kasdallah, Hakima Kbaier, Hatem Ben Salem, Sonia Blibech, Asma Bouziri, Mohamed Douagi
BACKGROUND: Povidone iodine (PVI) pleurodesis is commonly used in adult. However, this procedure is still nonconsensual in newborns. AIMS: This article aimed to report a new case of refractory congenital chylothorax (CCT) managed with PVI pleurodesis with a review of previousreported cases. METHODS: a systematic review of similar cases published in PubMed. Clinical patterns, therapeutic modalities and outcome variables werereported. RESULT: In a full term neonate presenting refractory CCT, PVI pleurodesis was performed at day 16 of life by one intrapleural instillation of PVI4% with rapid success and no side effects...
December 2016: La Tunisie Médicale
https://www.readbyqxmd.com/read/28986152/vocal-evaluation-of-children-with-congenital-hypothyroidism
#19
Ana Paula Dassie-Leite, Mara Behlau, Suzana Nesi-França, Monica Nunes Lima, Luiz de Lacerda
OBJECTIVE: To evaluate the vocal characteristics of a group of children with congenital hypothyroidism (CH) and the association of these characteristics with the children's clinical, laboratory, and therapeutic profiles. MATHERIAL AND METHODS: Observational, analytical, cross-sectional study including 200 prepubertal children, of whom 100 had CH (study group [SG]) and 100 had no CH (control group [CG]). The following parameters were evaluated: 1) history (identification, complaints, and interfering variables), 2) auditory-perceptual and acoustic evaluation (samples analyzed by a group of specialists, and objectively by a computer program), 3) self-assessment scores in the Pediatric Voice-Related Quality-of-Life (PVRQoL) survey, 4) laryngological evaluation (presence or absence of laryngeal lesions and data regarding glottal closure), and 5) medical records (CH etiology, age at treatment initiation, disease severity at diagnosis, treatment quality, and thyroid function tests on the day of the examination)...
October 3, 2017: Journal of Voice: Official Journal of the Voice Foundation
https://www.readbyqxmd.com/read/28977031/sudden-sensorineural-hearing-loss-associated-with-inner-ear-lesions-detected-by-magnetic-resonance-imaging
#20
Jiwon Cho, Hanjae Cheon, Jung Hye Park, Hyo-Jeong Lee, Hyung-Jong Kim, Hyo Geun Choi, Ja-Won Koo, Sung Kwang Hong
Although recent advances in magnetic resonance imaging (MRI) techniques have contributed to the detection of tiny lesions in the internal auditory canal (IAC) that may be responsible for sudden sensorineural hearing loss (SSNHL), there have been relatively few studies on the clinical characteristics of intra-labyrinthine hemorrhage (ILH) and labyrinthitis versus those regarding IAC tumors. Our purpose was to investigate the frequency of those IAC lesions on MRI and their clinical characteristics. Initial MRIs of 200 patients with SSNHL (93 men, 107 women; mean age = 48...
2017: PloS One
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