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clinical thyroid function test

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https://www.readbyqxmd.com/read/28225316/adverse-event-reporting-in-patients-treated-with-thyroid-hormone-extract
#1
Rupendra T Shrestha, Alan Malabanan, Bryan R Haugen, Elliott G Levy, James V Hennessey
OBJECTIVE: Thyroid hormone extract is used for the treatment of thyroid disorders but limited data exist on adverse events commonly noted by the physicians associated with this use. The purpose of this survey was to report adverse events observed by expert physicians managing patients treated for thyroid disease with thyroid hormones. METHODS: Members of the American Thyroid Association, The Endocrine Society and the American Association of Clinical Endocrinologists developed a survey instrument modeled on the FDA's reported adverse events for levothyroxine that would effectively assess the clinical experience of frequent prescribers of thyroid hormone...
February 22, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28171716/reference-intervals-of-thyroid-hormones-during-pregnancy-in-korea-an-iodine-replete-area
#2
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-Young Oh
Background/Aims: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. Methods: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies...
February 8, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28158982/study-protocol-thyroid-hormone-replacement-for-untreated-older-adults-with-subclinical-hypothyroidism-a-randomised-placebo-controlled-trial-trust
#3
David J Stott, Jacobijn Gussekloo, Patricia M Kearney, Nicolas Rodondi, Rudi G J Westendorp, Simon Mooijaart, Sharon Kean, Terence J Quinn, Naveed Sattar, Kirsty Hendry, Robert Du Puy, Wendy P J Den Elzen, Rosalinde K E Poortvliet, Jan W A Smit, J Wouter Jukema, Olaf M Dekkers, Manuel Blum, Tinh-Hai Collet, Vera McCarthy, Caroline Hurley, Stephen Byrne, John Browne, Torquil Watt, Douglas Bauer, Ian Ford
BACKGROUND: Subclinical hypothyroidism (SCH) is a common condition in elderly people, defined as elevated serum thyroid-stimulating hormone (TSH) with normal circulating free thyroxine (fT4). Evidence is lacking about the effect of thyroid hormone treatment. We describe the protocol of a large randomised controlled trial (RCT) of Levothyroxine treatment for SCH. METHODS: Participants are community-dwelling subjects aged ≥65 years with SCH, diagnosed by elevated TSH levels (≥4...
February 3, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28144251/permanent-and-transient-congenital-hypothyroidism-in-hamadan-west-province-of-iran
#4
Zahra Razavi, Lida Mohammadi
BACKGROUND: Primary congenital hypothyroidism (CH) is the most common treatable cause of mental retardation and can be classified into permanent and transient types. The purpose of this study was to determine the prevalence of permanent and transient congenital hypothyroidism (CH) in Hamadan, West province of Iran. METHODS: The study population included all cases with primary congenital hypothyroidism, which were confirmed by thyroid function tests (TSH levels ≥ 10 mIU/L)...
October 2016: International Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28143459/frequency-and-determinants-of-thyroid-autoimmunity-in-ghanaian-type-2-diabetes-patients-a-case-control-study
#5
COMPARATIVE STUDY
Osei Sarfo-Kantanka, Fred Stephen Sarfo, Eunice Oparebea Ansah, Ernest Yorke, Josephine Akpalu, Bernard C Nkum, Benjamin Eghan
BACKGROUND: The link between type 1 diabetes and thyroid autoimmunity is well described. The same cannot be said for type 2 diabetes where results have been mixed so far. We investigated the prevalence and determinants of thyroid autoimmunity among Ghanaian type 2 diabetes patients. METHODS: This was a case-control study involving 302 type 2 diabetes patients and 310 non - diabetic controls aged 40-80 years. Anthropometric and blood pressure measurements were obtained...
January 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28138875/electronic-detection-of-delayed-test-result-follow-up-in-patients-with-hypothyroidism
#6
Ashley N D Meyer, Daniel R Murphy, Aymer Al-Mutairi, Dean F Sittig, Li Wei, Elise Russo, Hardeep Singh
BACKGROUND: Delays in following up abnormal test results are a common problem in outpatient settings. Surveillance systems that use trigger tools to identify delayed follow-up can help reduce missed opportunities in care. OBJECTIVE: To develop and test an electronic health record (EHR)-based trigger algorithm to identify instances of delayed follow-up of abnormal thyroid-stimulating hormone (TSH) results in patients being treated for hypothyroidism. DESIGN: We developed an algorithm using structured EHR data to identify patients with hypothyroidism who had delayed follow-up (>60 days) after an abnormal TSH...
January 30, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28124642/the-effects-of-radioactive-iodine-therapy-on-olfactory-function
#7
Bilici Suat, Edizer Deniz Tuna, Yigit Ozgur, Yildiz Muhammet, Cermik Tevfik Fikret
PURPOSE: To determine the possible adverse effects of radioactive iodine (RAI) treatment on the olfactory functions of patients with differentiated thyroid carcinoma. MATERIALS AND METHODS: This prospective clinical study included 63 Turkish patients who had been diagnosed with papillary thyroid carcinoma only to ensure homogeneity. The Connecticut Chemosensory Clinical Research Center olfactory test was administered at 1 week before treatment and at the third week and the first year after treatment...
November 1, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/28119302/cognitive-functioning-in-coronary-artery-disease-patients-associations-with-thyroid-hormones-n-terminal-pro-b-type-natriuretic-peptide-and-high-sensitivity-c-reactive-protein
#8
Julius Burkauskas, Adomas Bunevicius, Julija Brozaitiene, Julius Neverauskas, Peter Lang, Robert Duwors, Narseta Mickuviene, Robertas Bunevicius
OBJECTIVE: To determine whether biomarkers of health such as serum levels of free triiodothyronine (fT3), total triiodothyronine (TT3), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity C-reactive protein (hsCRP) impact the cognitive functioning of coronary artery disease (CAD) patients. METHOD: About 278 patients were evaluated for socio-demographic and clinical risk factors as well as fT3, TT3, NT-proBNP, and hsCRP serum levels. Cognitive functioning measures included the Mini-Mental State Examination, Digit Span Test, Digit Symbol Substitution Test (DSST), and Trail Making Test A (TMTA)...
January 23, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28117377/albuminuria-is-an-independent-risk-factor-of-t4-elevation-in-chronic-kidney-disease
#9
Xin Du, Binbin Pan, Wenwen Li, Yonghua Zou, Xi Hua, Wenjuan Huang, Xin Wan, Changchun Cao
This study was to explore the association between thyroid dysfunction and albuminuria. 581 cases with chronic kidney disease (CKD) were included in this study. The clinical characteristics consisted of sex, age, serum creatinine, urinary albumin-to-creatinine ratio (ACR), thyroid function were recorded. Estimated glomerular filtration rate (eGFR) was calculated by CKD-EPI four-level race equation. Prevalence of different thyroid diseases was calculated by chi-square test. Levels of thyroid hormone were compared among different albuminuria groups by Kruskal-Wallis test...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28114247/neuroendocrine-dysfunction-in-a-young-athlete-with-concussion-a-case-report
#10
David M Langelier, Gregory A Kline, Chantel T Debert
An 18-year-old female ringette and basketball player presented to our sport concussion clinic 27 months after concussion with fatigue, headache, exercise intolerance, polyuria, nocturia, and difficulties concentrating. Her history was remarkable for 4 previous concussions. Her neurologic examination was normal. Neuroendocrine screen including thyroid function, morning cortisol, glucose, and insulin-like growth factor-1 (screening test for growth hormone deficiency) were normal. Further testing for growth hormone deficiency with an insulin hypoglycemia test revealed severe growth hormone deficiency...
January 20, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28097176/a-comparison-between-the-quality-of-life-and-mental-health-of-patients-with-hypothyroidism-and-normal-people-referred-to-motahari-clinic-of-shiraz-university-of-medical-sciences
#11
Mahnaz Rakhshan, Alireza Ghanbari, Atefeh Rahimi, Issac Mostafavi
BACKGROUND: Hypothyroidism is a condition caused by a decrease in the thyroid gland hormones. This disease is very common at all age ranges. Regarding its long term therapeutic procedure, this disease can affect the quality of life and the mental health of the patients. The present study aimed to compare the quality of life and mental health in hypothyroid patients and normal people. METHODS: This descriptive-analytic investigation was performed using convenience sampling on 95 patients with hypothyroidism and 95 normal cases referring to Motahari clinic between October 2014 and August 2015...
January 2017: International Journal of Community Based Nursing and Midwifery
https://www.readbyqxmd.com/read/28088179/chronic-constipation-diagnosis-and-treatment-evaluation-the-chro-co-di-t-e-study
#12
Massimo Bellini, Paolo Usai-Satta, Antonio Bove, Renato Bocchini, Francesca Galeazzi, Edda Battaglia, Pietro Alduini, Elisabetta Buscarini, Gabrio Bassotti
BACKGROUND: According to Rome criteria, chronic constipation (CC) includes functional constipation (FC) and irritable bowel syndrome with constipation (IBS-C). Some patients do not meet these criteria (No Rome Constipation, NRC). The aim of the study was is to evaluate the various clinical presentation and management of FC, IBS-C and NRC in Italy. METHODS: During a 2-month period, 52 Italian gastroenterologists recorded clinical data of FC, IBS-C and NRC patients, using Bristol scale, PAC-SYM and PAC-QoL questionnaires...
January 14, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/28081173/effect-of-rifampin-on-thyroid-function-test-in-patients-on-levothyroxine-medication
#13
Hye In Kim, Tae Hyuk Kim, Hosu Kim, Young Nam Kim, Hye Won Jang, Jae Hoon Chung, Seong Mi Moon, Byung Woo Jhun, Hyun Lee, Won-Jung Koh, Sun Wook Kim
BACKGROUND: Levothyroxine (LT4) and rifampin (RIF) are sometimes used together; however, no clinical studies have assessed the effects of these drugs on thyroid function or the need to adjust LT4 dose. METHODS: We retrospectively reviewed the records of 71 Korean patients who started RIF during LT4 treatment. Clinically relevant cases that required dose adjustment according to the American Thyroid Association (ATA)/American Association of Clinical Endocrinologists (AACE) guidelines were identified, and risk factors of increased LT4 dose were analyzed...
2017: PloS One
https://www.readbyqxmd.com/read/28078322/diagnostic-dilemma-in-discordant-thyroid-function-tests-due-to-thyroid-hormone-autoantibodies
#14
Panudda Srichomkwun, Neal H Scherberg, Jasminka Jakšić, Samuel Refetoff
OBJECTIVE: Assay interference could be the cause of abnormal thyroid function tests. Early recognition prevents inappropriate patient management. The objective of this report is to present a case with discordant thyroid function tests in different thyroid assay platforms due to thyroid autoantibodies. METHODS: We present a case her family, laboratory data and methods that investigate immunoassay interference. RESULTS: A 21-year-old woman with autoimmune thyroid disease was treated for hypothyroidism with levothyroxine and noted to have elevated total and free thyroxine, free triiodothyronine but normal thyroid-stimulating hormone...
2017: AACE Clin Case Rep
https://www.readbyqxmd.com/read/28071990/natural-course-of-euthyroidism-and-clues-for-early-diagnosis-of-thyroid-dysfunctions-tehran-thyroid-study-tts
#15
Atieh Amouzegar, Zahra Ghaemmaghami, Maani Beygi, Safoora Gharibzadeh, Ladan Mehran, Maryam Tohidi, Fereidoun Azizi
OBJECTIVE: Considering the limited data available on the natural course of euthyroidism, this study was designed to evaluate the progression in time from euthyroidism to subclinical or overt hypo - or hyperthyroidism. METHODS: This study was conducted within the framework of the Tehran Thyroid cohort study (TTS), in which 5783 individuals aged 40.4 ± 0.2 years were followed for 6 years. The overall loss to follow-up rate was 8.3%. After applying exclusion criteria, data of 4204 euthyroid subjects remained for analysis of a six-year natural course analysis...
January 10, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28057507/association-between-thyroid-hormone-parameters-and-dyslipidemia-among-type-2-diabetes-mellitus-patients-comparative-cross-sectional-study
#16
Amare Desalegn Wolide, Belay Zawdie, Tilahun Alemayehu, Samuel Tadesse
BACKGROUND: The relationship between thyroid function and lipid profile has been documented in T2DM and healthy subjects. The aim of the current study was to assess the association between thyroid hormone parameters and dyslipidemia in T2DM and non-diabetic study participants. METHOD AND MATERIALS: In this comparative cross-sectional study, 214 type 2 diabetic and 214 non-diabetic study participants were enrolled. Clinical and anthropometric data were collected from all study participants...
December 26, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28056690/2016-guidelines-of-the-american-thyroid-association-for-the-diagnosis-and-management-of-thyroid-disease-during-pregnancy-and-the-postpartum
#17
Erik K Alexander, Elizabeth N Pearce, Gregory A Brent, Rosalind S Brown, Herbert Chen, Chrysoula Dosiou, William Grobman, Peter Laurberg, John H Lazarus, Susan J Mandel, Robin Peeters, Scott Sullivan
BACKGROUND: Thyroid disease in pregnancy is a common clinical problem. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were first published in 2011, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid disease in women during pregnancy, preconception and the postpartum period...
January 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28028828/thyroid-abnormalities-following-the-use-of-ctla-4-and-pd-1-inhibitors-in-the-treatment-of-melanoma
#18
D L Morganstein, Z Lai, L Spain, S Diem, D Levine, C Mace, M Gore, J Larkin
CONTEXT: Checkpoint inhibitors are emerging as important cancer therapies, but are associated with a high rate of immune side effects, including endocrinopathy. OBJECTIVE: To determine the burden of thyroid dysfunction in patients with melanoma treated with immune checkpoint inhibitors and describe the clinical course. DESIGN AND PATIENTS: Consecutive patients with melanoma treated with either Ipilimumab, Nivolumab, Pembrolizumab or the combination of Ipilimumab and Nivolumab were identified...
December 27, 2016: Clinical Endocrinology
https://www.readbyqxmd.com/read/28008865/the-relationship-of-serum-zonulin-level-with-clinical-and-laboratory-parameters-in-childhood-obesity
#19
Tuncay Küme, Sezer Acar, Hale Tuhan, Gönül Çatlı, Ahmet Anık, Özlem Gürsoy Çalan, Ece Böber, Ayhan Abacı
OBJECTIVE: The aim of this study was to investigate the relationship between zonulin and clinical laboratory parameters in childhood obesity. METHODS: The study included obese children with a body mass index >95th percentile and healthy children who were similar age and gender distribution. Clinical (body mass index, waist circumferences, mid arm circumference, triceps skin fold, percentage of body fat, systolic blood pressure, diastolic blood pressure) and biochemical (glucose, insulin, lipids, thyroid function tests, cortisol, zonulin and leptin levels) parameters were measured...
December 23, 2016: Journal of Clinical Research in Pediatric Endocrinology
https://www.readbyqxmd.com/read/28004764/sheehan-syndrome
#20
Züleyha Karaca, Bashir A Laway, Hatice S Dokmetas, Hulusi Atmaca, Fahrettin Kelestimur
Sheehan syndrome or postpartum hypopituitarism is a condition characterized by hypopituitarism due to necrosis of the pituitary gland. The initial insult is caused by massive postpartum haemorrhage (PPH), leading to impaired blood supply to the pituitary gland, which has become enlarged during pregnancy. Small sella turcica size, vasospasms (caused by PPH) and/or thrombosis (associated with pregnancy or coagulation disorders) are predisposing factors; autoimmunity might be involved in the progressive worsening of pituitary functions...
December 22, 2016: Nature Reviews. Disease Primers
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