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https://www.readbyqxmd.com/read/28724141/selecting-patients-with-thin-melanoma-for-sentinel-lymph-node-biopsy-this-time-it-s-personal
#1
Vernon K Sondak, Jane L Messina, Jonathan S Zager
No abstract text is available yet for this article.
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28724122/association-between-patient-age-and-lymph-node-positivity-in-thin-melanoma
#2
Andrew J Sinnamon, Madalyn G Neuwirth, Pratyusha Yalamanchi, Phyllis Gimotty, David E Elder, Xiaowei Xu, Rachel R Kelz, Robert E Roses, Emily Y Chu, Michael E Ming, Douglas L Fraker, Giorgos C Karakousis
Importance: More than half of all new melanoma diagnoses present as clinically localized T1 melanoma, yet sentinel lymph node biopsy (SLNB) is controversial in this population given the overall low yield. Guidelines for SLNB have focused on pathologic factors, but patient factors, such as age, are not routinely considered. Objectives: To identify indicators of lymph node (LN) metastasis in thin melanoma in a large, generalizable data set and to evaluate the association between patient age and LN positivity...
July 19, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28721983/current-status-and-future-perspectives-of-sentinel-lymph-node-biopsy-in-oral-cancers
#3
EDITORIAL
Arvind Krishnamurthy
No abstract text is available yet for this article.
May 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28718896/nomograms-for-preoperative-prediction-of-axillary-nodal-status-in-breast-cancer
#4
L Dihge, P-O Bendahl, L Rydén
BACKGROUND: Axillary staging in patients with breast cancer and clinically node-negative disease is performed by sentinel node biopsy (SLNB). The aim of this study was to integrate feasible preoperative variables into nomograms to guide clinicians in stratifying treatment options into no axillary staging for patients with non-metastatic disease (N0), SLNB for those with one or two metastases, and axillary lymph node dissection (ALND) for patients with three or more metastases. METHODS: Patients presenting to Skåne University Hospital, Lund, with breast cancer were included in a prospectively maintained registry between January 2009 and December 2012...
July 18, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28718876/is-there-a-revision-needed-of-the-current-figo-staging-system
#5
Joseph Menczer
The FIGO staging system has undergone many modifications since it first appeared in about the middle of the previous century. Due to the use of modern diagnostic tools, namely computed tomography, magnetic resonance imaging, positron emission tomography, sentinel lymph node biopsy and of neoadjuvant chemotherapy, certain gynecological cancer cases cannot be allocated to a specific stage if one wishes to adhere strictly to FIGO requirements. In these circumstances such cases remain actually unstaged. This should prompt appropriate modifications of the current FIGO staging system so that it fulfills its aims...
July 18, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28718222/when-is-a-sentinel-node-biopsy-indicated-for-patients-with-primary-melanoma-an-update-of-the-australian-guidelines-for-the-management-of-cutaneous-melanoma
#6
REVIEW
David E Gyorki, Andrew Barbour, Mark Hanikeri, Victoria Mar, Shahneen Sandhu, John F Thompson
A sentinel lymph node biopsy is a surgical staging procedure performed for patients with primary cutaneous melanoma who are clinically lymph-node negative to determine whether there is low volume nodal metastasis in the draining lymph node field. A systematic review was recently performed to update the Australian clinical practice guidelines for the diagnosis and management of melanoma, addressing the question, 'When is a sentinel lymph node biopsy indicated?' This article discusses the findings of the systematic review and the evidence base for the updated guidelines...
July 17, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28715140/the-natural-history-of-thin-melanoma-and-the-utility-of-sentinel-lymph-node-biopsy
#7
Alison B Durham, Jennifer L Schwartz, Lori Lowe, Lili Zhao, Andrew G Johnson, Kelly L Harms, Christopher K Bichakjian, Amy P Orsini, Scott A McLean, Carol R Bradford, Mark S Cohen, Timothy M Johnson, Michael S Sabel, Sandra L Wong
BACKGROUND AND OBJECTIVES: Current literature may overestimate the risk of nodal metastasis from thin melanoma due to reporting of data only from lesions treated with SLNB. Our objective was to define the natural history of thin melanoma, assessing the likelihood of nodal disease, in order to guide selection for SLNB. METHODS: Retrospective review. The primary outcome was the rate of nodal disease. Clinicopathologic factors were evaluated to find associations with nodal disease...
July 17, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28707391/role-of-sentinel-lymph-node-biopsy-as-a-staging-procedure-in-patients-with-melanoma-a-critical-appraisal
#8
REVIEW
Omgo E Nieweg, Alan Cooper, John F Thompson
Worldwide, sentinel node (SN) biopsy for accurate staging is now part of the standard work-up of patients with melanomas ≥1.0 mm Breslow thickness, as it is for staging patients with breast cancer. Nuclear medicine imaging and surgical techniques have evolved to such a degree that a SN can be identified and removed in virtually every patient. Nevertheless, some opposition to a routine SN biopsy remains, perhaps due to a failure to appreciate the serious implications of incomplete or inaccurate staging. Guided by a critical appraisal of the available evidence, this review elucidates the definition of an SN, discusses the sensitivity and specificity of the information it provides, emphasises that it is a minor staging procedure that can lead to improved survival when followed by appropriate therapy, and explains the necessarily unconventional and complex design of the only randomised trial that addresses this subject...
July 14, 2017: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/28706535/which-factors-are-important-for-successful-sentinel-node-navigation-surgery-in-gastric-cancer-patients-analysis-from-the-senorita-prospective-multicenter-feasibility-quality-control-trial
#9
Ji Yeong An, Jae Seok Min, Young Joon Lee, Sang Ho Jeong, Hoon Hur, Sang Uk Han, Woo Jin Hyung, Gyu Seok Cho, Gui Ae Jeong, Oh Jeong, Young Kyu Park, Mi Ran Jung, Ji Yeon Park, Young Woo Kim, Hong Man Yoon, Bang Wool Eom, Keun Won Ryu
BACKGROUND: We investigated the results of quality control study prior to phase III trial of sentinel lymph node navigation surgery (SNNS). METHODS: Data were reviewed from 108 patients enrolled in the feasibility study of laparoscopic sentinel basin dissection (SBD) in gastric cancer. Seven steps contain tracer injection at submucosa (step 1) and at four sites (step 2) by intraoperative esophagogastroduodenoscopy (EGD), leakage of tracer (step 3), injection within 3 minutes (step 4), identification of at least one sentinel basin (SB) (step 5), evaluation of sentinel basin nodes (SBNs) by frozen biopsy (step 6), and identification of at least five SBNs at back table and frozen sections (step 7)...
2017: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/28705929/use-of-tc-99m-tilmanocept-as-a-single-agent-for-sentinel-lymph-node-identification-in-breast-cancer-a-retrospective-pilot-study
#10
Jonathan Takei Unkart, Anne Marie Wallace
Introduction: Tc-99m tilmanocept (TcTM) received recent FDA-approval for lymphatic mapping. However, no prior studies have evaluated the use of TcTM as a single agent in sentinel lymph node (SLN) biopsy in breast cancer. Methods: We executed this retrospective, pilot study to assess the ability of TcTM to identify sentinel nodes as a single agent in clinically node-negative breast cancer patients. Patients received a single, intradermal injection overlying the tumor of either 0.5 mCi TcTM the day-of surgery or 2...
July 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28700325/precise-intraoperative-sentinel-lymph-node-biopsies-guided-by-lymphatic-drainage-in-breast-cancer
#11
Xiaoyan Li, Sisi Chen, Liyu Jiang, Xiaoli Kong, Tingting Ma, Hong Xu, Qifeng Yang
The purpose of this study was to present a novel surgical method for intraoperative precise sentinel lymph node biopsy (SLNB) and to determine its clinical efficacy and sensitivity in breast cancer patients. The sentinel lymph nodes (SLNs) were preoperatively evaluated by axillary ultrasound. The intraoperative detection of SLNs was guided by lymphatic drainage pathway. The lymphatic vessels and SLNs were visualized. During operation, we searched for all the true SLNs (trSLNs), para-SLNs (paSLNs) and post-SLNs (poSLNs) followed lymphatic drainage ducts...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28700132/non-invasive-sentinel-lymph-node-mapping-and-needle-guidance-using-clinical-handheld-photoacoustic-imaging-system-in-small-animal
#12
Kathyayini Sivasubramanian, Vijitha Periyasamy, Manojit Pramanik
Translating photoacoustic imaging into clinical setup is a challenge. Handheld clinical real-time photoacoustic imaging systems are not common. In this work, we report an integrated photoacoustic and clinical ultrasound imaging system by combining light delivery with the ultrasound probe for sentinel lymph node imaging and needle guidance in small animal. The open access clinical ultrasound platform allows seamless integration of photoacoustic imaging resulting in the development of handheld real-time photoacoustic imaging probe...
July 12, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28699134/intraoperative-tumor-detection-using-a-ratiometric-activatable-fluorescent-peptide-a-first-in-human-phase-1-study
#13
Jonathan T Unkart, Steven L Chen, Irene L Wapnir, Jesús E González, Alec Harootunian, Anne M Wallace
BACKGROUND: Positive surgical margins remain a significant challenge in breast cancer surgery. This report describes the use of a novel, first-in-human ratiometric activatable cell-penetrating peptide in breast cancer surgery. METHODS: A two-part, multi-institutional phase 1 trial of AVB-620 with a 3+3 dose escalation and dose-expansion cohorts was conducted. The patients received an infusion of AVB-620 2-20 h before planned lumpectomy/mastectomy and sentinel node biopsy/axillary dissection...
July 11, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28699042/is-the-non-sentinel-lymph-node-compartment-the-next-site-for-melanoma-progression-from-the-sentinel-lymph-node-compartment-in-the-regional-nodal-basin
#14
Andrei Rios-Cantu, Ying Lu, Victor Melendez-Elizondo, Michael Chen, Alejandra Gutierrez-Range, Niloofar Fadaki, Suresh Thummala, Carla West-Coffee, James Cleaver, Mohammed Kashani-Sabet, Stanley P L Leong
Melanoma patients with additional positive lymph nodes in the completion lymph node dissection (CLND) following a positive sentinel lymph node (SLN) biopsy would have a poorer prognosis than patients with no additional positive lymph nodes. We hypothesize that the progression of disease from the SLN to the non-SLN compartment is orderly and is associated with the worsening of the disease status. Thus, the SLN and non-SLN compartments are biologically different in that cancer cells, in general, arrive in the SLN compartment before spreading to the non-SLN compartment...
July 11, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28698757/new-safety-margins-for-melanoma-surgery-nice-possibility-for-drinking-of-just-that-cup-of-coffee
#15
Georgi Tchernev, Anastasiya Atanasova Chokoeva
BACKGROUND: The American Joint Committee on Cancer (AJCC's) skin melanoma surgical treatment recommendations from 2011 are characterised by a prima facie "freedom of choice" regarding how extensive should be the excisions for melanomas with tumour thickness up to 2 mm and melanoma in situ. It is unclear why the recommended surgical security margins vary between 0.5 and 1 cm for melanoma in situ, whereas for melanomas with a tumour thickness of up to 1.99 mm, the range of variation is also between 1 and 2 cm, without specifying when the surgical field should be broader and, narrower, accordingly...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28697552/the-importance-of-tattoo-pigment-in-sentinel-lymph-nodes
#16
Atilla Soran, Ebru Menekse, Amal Kanbour-Shakir, Kaori Tane, Emilia Diego, Marguerite Bonaventura, Ronald Johnson
BACKGROUND: The presence of pigment in axillary lymph nodes (LN) secondary to migration of tattoo ink can imitate the appearance of a blue sentinel lymph node (SLN) on visual inspection, causing the operator to either miss the true SLN or excise more than is needed. OBJECTIVE: We present patients with tattoos ipsilateral to an early stage breast cancer who underwent a SLN biopsy. METHODS: Patients were retrospectively reviewed from medical records and clinicopathologic data was collected...
July 6, 2017: Breast Disease
https://www.readbyqxmd.com/read/28690675/development-of-sentinel-node-biopsy-roll-and-iart-in-early-breast-cancer-at-the-european-institute-of-oncology-milan-ieo
#17
REVIEW
Giovanni Paganelli
The problem of unnecessary axillary clearance in many patients with early breast cancer was certainly a major issue at IEO when we started working with Prof. Umberto Veronesi in 1994. At that time, axillary dissection in EBC was offered to all patients and this procedure was often hotly debated during our multidisciplinary breast cancer meetings. The question as to whether we could avoid axillary dissection by using PET scans or other nuclear medicine methods was frequently asked by Veronesi. This eventually prompted us to investigate whether, as for melanoma patients, the sentinel node biopsy (SNB) approach could reliably be applied to breast cancer...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/28689448/metastatic-melanoma-in-sentinel-node-negative-patients-the-ottawa-experience
#18
Chloe E Ward, Jennifer L MacIsaac, Caroline E Heughan, Louis Weatherhead
BACKGROUND: Lymph node involvement is a major independent prognostic factor for survival in patients with malignant melanoma. Sentinel lymph node biopsy (SLNB) detection of microscopic nodal melanoma has been shown to improve both 5-year survival and 5-year disease-free survival. OBJECTIVE: To determine the rate of metastatic melanoma in SLNB-negative patients at long-term follow-up. METHODS: Study subjects include all 152 patients who had a negative SLNB and were followed at the Ottawa Regional Cancer Centre (ORCC) between 1999 and 2004...
July 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28688667/clinical-utility-of-the-additional-use-of-blue-dye-for-indocyanine-green-for-sentinel-node-biopsy-in-breast-cancer
#19
Yinan Ji, Ningbin Luo, Yi Jiang, Qiuyun Li, Wei Wei, Huawei Yang, Jianlun Liu
BACKGROUND: Indocyanine green (ICG) is widely used as a tracer in sentinel lymph node biopsy (SLNB) of patients with breast cancer. Whether SLNB performance can be improved by supplementing ICG with methylene blue dye remains controversial. This study compared the performance of SLNB when ICG was used alone or with blue dye. MATERIALS AND METHODS: Consecutive patients with T1-3 primary breast cancer at our hospital were recruited into our study and randomized to undergo SLNB with ICG alone (n = 62) or with the combination of ICG and blue dye (n = 65)...
July 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28688661/use-of-axillary-lymph-node-dissection-alnd-in-patients-with-micrometastatic-breast-cancer
#20
Madison Collins, Cristina O'Donoghue, Weihong Sun, Jun-Min Zhou, Zhenjun Ma, Christine Laronga, Marie Catherine Lee
BACKGROUND: Sentinel lymph node (SLN) biopsy is the current prognostic tool for clinically node-negative breast cancer patients. If the SLN reveals macrometastasis, axillary lymph node dissection (ALND) is recommended. However, the use of ALND in patients with micrometastasis is debated. The objective of this study was to assess the utilization of ALND in the treatment of micrometastatic breast cancer. METHODS: An IRB approved, retrospective study of a pooled dataset of breast cancer patients with micrometastatic disease on SLN biopsy was performed...
July 2017: Journal of Surgical Research
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