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sentinel node biopsy

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https://www.readbyqxmd.com/read/29352595/axillary-tumour-burden-in-women-with-one-abnormal-node-on-ultrasound-compared-to-women-with-multiple-abnormal-nodes
#1
S Puri, N Sharma, R G Newcombe, M Kaushik, M Al-Attar, S Pascaline, M Hajaj, M G Wallis, B Elsberger, A Goyal
AIM: To determine if the number of abnormal nodes seen on preoperative axillary ultrasound (AUS) is a predictor of the number of positive nodes at histology for women with needle-biopsy-proven positive nodes. MATERIALS AND METHODS: This prospective multicentre cohort study included consecutive patients with early breast cancer who had needle-biopsy-proven positive nodes on AUS and underwent axillary lymph node dissection (ALND) between October 2015 and July 2016...
January 15, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/29352214/handheld-magnetic-probe-with-permanent-magnet-and-hall-sensor-for-identifying-sentinel-lymph-nodes-in-breast-cancer-patients
#2
Masaki Sekino, Akihiro Kuwahata, Tetsu Ookubo, Mikio Shiozawa, Kaichi Ohashi, Miki Kaneko, Itsuro Saito, Yusuke Inoue, Hiroyuki Ohsaki, Hiroyuki Takei, Moriaki Kusakabe
The newly developed radioisotope-free technique based on magnetic nanoparticle detection using a magnetic probe is a promising method for sentinel lymph node biopsy. In this study, a novel handheld magnetic probe with a permanent magnet and magnetic sensor is developed to detect the sentinel lymph nodes in breast cancer patients. An outstanding feature of the probe is the precise positioning of the sensor at the magnetic null point of the magnet, leading to highly sensitive measurements unaffected by the strong ambient magnetic fields of the magnet...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29350487/pediatric-patients-with-cutaneous-melanoma-a-european-study
#3
Ines B Brecht, Angela De Paoli, Gianni Bisogno, Daniel Orbach, Dominik T Schneider, Ulrike Leiter, Sonja Offenmueller, Giovanni Cecchetto, Jan Godzinski, Ewa Bien, Teresa Stachowicz-Stencel, Tal Ben-Ami, Stefano Chiaravalli, Andrea Maurichi, Gian Luca De Salvo, Silvia Sorbara, Christine Bodemer, Claus Garbe, Yves Reguerre, Andrea Ferrari
INTRODUCTION: Cutaneous melanoma is rare in childhood and published studies have mainly been retrospective single-institution series or small case series. Given the absence of clinical protocols dedicated to pediatric melanoma, the treatment approach is generally extrapolated from the ones applied to adults. METHODS: Coordinated by the European Cooperative Study Group for Pediatric Rare Tumors (EXPeRT), this study collected patients prospectively registered between 2002 and 2012 under national cooperative projects dedicated to rare pediatric tumors in Italy, Poland, Germany, and France...
January 19, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29349757/management-of-the-axilla-in-early-breast-cancer
#4
Monica G Valero, Mehra Golshan
Management of the axilla in early breast cancer patients has significantly evolved in the last several decades. With the arrival of the sentinel lymph node biopsy, surgical practice for axillary staging in patients with early breast cancer has become gradually less invasive and formal axillary lymph node dissection has been confined to selected patients. Over the last two decades, evidence from randomized clinical trials have allowed for the de-escalation of axillary surgery in the management of early stage breast cancer...
2018: Cancer Treatment and Research
https://www.readbyqxmd.com/read/29344239/prognostic-impact-of-preoperative-serum-interleukin-6-levels-in-patients-with-early-stage-oral-squamous-cell-carcinoma-defined-by-sentinel-node-biopsy
#5
Hiroyuki Goda, Masato Okamoto, Koh-Ichi Nakashiro, Satoshi Hino, Ryuichi Murase, Hiroyuki Hamakawa
Failure to detect recurrence and lymph node metastasis early represents a fundamental barrier to the improvement of survival rate in early stage oral squamous cell carcinoma (OSCC). The present study evaluated the association between serum interleukin-6 (IL-6) level and clinical outcomes in patients with early stage OSCC patients defined by sentinel node biopsy (SNB). A total of 53 patients with clinical stage I/II OSCC who underwent SNB were enrolled. SNB was determined by a radioisotope method, and was evaluated by histopathological examination and genetic analysis...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29332705/cutaneous-squamous-cell-carcinoma-management-of-advanced-and-high-stage-tumors
#6
REVIEW
Syril Keena T Que, Fiona O Zwald, Chrysalyne D Schmults
While the majority of cutaneous squamous cell carcinomas (cSCCs) can be treated surgically, the additional work-up and treatments indicated for high-risk cSCC remain undefined. In recent years, improvements in tumor staging systems have allowed for the more accurate stratification of tumors into high- and low-risk categories. This insight, along with the publication of cSCC guidelines, brings us closer to the development of a consensus approach. The second article in this continuing medical education series addresses in question and answer format the most common questions related to advanced and high-stage cSCCs, with a simplified flowchart...
February 2018: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29330718/spect-ct-adds-distinct-lymph-node-basins-and-influences-radiologic-findings-and-surgical-approach-for-sentinel-lymph-node-biopsy-in-head-and-neck-melanoma
#7
Becky B Trinh, Brandon C Chapman, Ana Gleisner, Jennifer J Kwak, Rustain Morgan, Martin D McCarter, Csaba Gajdos, Nicole Kounalakis
BACKGROUND: Planar lymphoscintigraphy (PL) has a lower detection rate of sentinel lymph nodes (SLNs) in head and neck melanoma compared with other sites. We assessed situations when single-photon emission computed tomography/computed tomography (SPECT/CT) identified nodes not seen by PL. We also evaluated the impact of SPECT/CT on surgical approach and oncologic outcomes. METHODS: Patients who underwent SLN biopsy (SLNB) for head and neck melanoma with PL and SPECT/CT between November 2011 and December 2016 were included...
January 12, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29329752/role-of-frozen-section-in-sentinel-lymph-node-biopsy-for-breast-cancer-in-the-era-of-the-acosog-z0011-and-ibcsg-23-10-trials
#8
Augusto Lombardi, Giuseppe Nigri, Stefano Maggi, Gianluca Stanzani, Valeria Vitale, Andrea Vecchione, Alessandro Nania, Claudio Amanti
BACKGROUND: Intraoperative frozen sections (FS) of sentinel lymph nodes (SLN) were evaluated to avoid the need for deferred axillary lymph node dissection (ALND) in patients with early breast cancer (EBC). However, FS has low sensitivity for detecting micro-metastases (<2 mm), resulting in patients who later undergo deferred ALND. The aim of the study was to determine the best clinical approach for selecting patients who would derive real benefit from ALND, as well as to minimize the functional and psychological damage caused by delayed surgery, and the risk of undertreating EBC patients...
January 9, 2018: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/29316475/the-sentinel-lymph-node-spread-determines-quantitatively-melanoma-seeding-to-non-sentinel-lymph-nodes-and-survival
#9
Anja Ulmer, Klaus Dietz, Melanie Werner-Klein, Hans-Martin Häfner, Claudia Schulz, Philipp Renner, Florian Weber, Helmut Breuninger, Martin Röcken, Claus Garbe, Gerhard Fierlbeck, Christoph A Klein
INTRODUCTION: Complete lymph node dissection (CLND) after a positive sentinel node (SN) biopsy provides important prognostic information in melanoma patients but has been questioned for therapeutic use recently. We explored whether quantification of the tumour spread to SNs may replace histopathology of non-sentinel nodes (NSNs) for staging purposes. PATIENTS AND METHODS: We quantified melanoma spread in SNs and NSNs in 128 patients undergoing CLND for a positive SN...
January 6, 2018: European Journal of Cancer
https://www.readbyqxmd.com/read/29309343/commentary-on-impact-of-national-comprehensive-cancer-network-guidelines-on-case-selection-and-outcomes-for-sentinel-lymph-node-biopsy-in-thin-melanoma
#10
Douglas Grossman, Glen M Bowen
No abstract text is available yet for this article.
January 5, 2018: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29307097/robotic-inguinal-lymph-node-dissection-for-melanoma-a-novel-approach-to-a-complicated-problem
#11
G Alan Hyde, Nathan L Jung, Alvaro A Valle, Syamal D Bhattacharya, Christopher E Keel
BACKGROUND: Indications for superficial inguinal lymph node (ILN) dissection in melanoma include fine needle aspiration or clinically positive ILN and sentinel lymph nodes (SLN). Open inguinal lymphadenectomy may be complicated by poor wound healing, deep vein thrombosis, and lymphedema. Technical considerations and case series of a novel surgical approach, robotic inguinal lymphadenectomy, are presented. METHODS: This is a case series of four robotic ILN dissections for melanoma at a tertiary care facility...
January 6, 2018: Journal of Robotic Surgery
https://www.readbyqxmd.com/read/29303381/are-we-cutting-enough-a-five-year-audit-of-melanoma-excision-margins-in-the-south-east-of-ireland
#12
Catherine Tracy Cronin, Jack Allen, Ken Patterson, Gerrard O'Donoghue
AIM: Malignant melanoma is the fifth commonest invasive cancer in Ireland. The British Association of Dermatology (BAD) guidelines are currently the recognized standard for melanoma related surgery. The aim was to examine adherence to BAD guidelines and establish contributing factors resulting in non-adherence to guidelines in a group of melanoma patients in the South East Region of Ireland. METHODS: A retrospective review of a prospectively maintained melanoma registry of all patients undergoing surgery in the South East Region of Ireland from January 2011 to 2016 was performed...
January 5, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29289416/lymphatic-transit-rate-as-a-predictive-parameter-for-nodal-metastasis-in-primary-limb-malignant-melanoma
#13
Masao Fujiwara, Takahiro Suzuki, Akira Kasuya, Takatoshi Shimauchi, Hidekazu Fukamizu, Yoshiki Tokura
BACKGROUND: The status of sentinel lymph node (SLN) is one of the most predictive prognostic factors in patients with clinically localized malignant melanomas (MMs). However, since the positive SLN metastatic rate is as low as 20%, it is desirable to minimize SLN biopsy performance with imaging. By dynamic lymphoscintigraphy, we have proposed the lymphatic transit rate (LTR), the value that the distance between the primary lesion and SLN is divided by scintigraphic saturation time. LTR represents the scintigraphic saturation velocity and can be used for evaluation of metastasis of skin cancers...
December 24, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/29289334/does-preoperative-axillary-staging-lead-to-overtreatment-of-women-with-screen-detected-breast-cancer
#14
M G Wallis, F Kilburn-Toppin, S Taylor-Phillips
AIM: To determine the impact of preoperative axillary ultrasound staging in a screen-detected breast cancer population. MATERIALS AND METHODS: Ultrasound and needle biopsy staging results alongside reference standard sentinel lymph node biopsy and axillary lymph node dissection were extracted retrospectively from the unit's computer records between 1 April 2008 and 31 March 2015. Axillary staging was compared with final histopathology and treatment. RESULTS: Of the 215,661 screening examinations performed, 780 invasive cancers were diagnosed, which had preoperative axillary staging data, of which 162 (20...
December 27, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29288008/usage-and-survival-implications-of-surgical-staging-of-inguinal-lymph-nodes-in-intermediate-to-high-risk-clinical-localized-penile-cancer-a-propensity-score-matched-analysis
#15
Solomon L Woldu, Bo Ci, Ryan C Hutchinson, Laura-Maria Krabbe, Nirmish Singla, Niccolo M Passoni, Timothy N Clinton, Ganesh V Raj, David S Miller, Arthur I Sagalowsky, Yair Lotan, Yang Xie, Vitaly Margulis, Aditya Bagrodia
OBJECTIVES: To evaluate the usage of surgical staging of inguinal lymph nodes (SSILNs) in the United States for intermediate to high-risk, clinically localized penile squamous cell cancer (SCC), to explore patient and hospital factors associated with omission of this staging, and to evaluate the effect on survival. PATIENTS AND METHODS: Retrospective, observational study using the National Cancer Database from 2004 to 2014 of 1,689 men diagnosed with pT1b-T3, cN0 penile SCC, who by current guidelines should receive SSILNs-either by inguinal lymph node (ILN) dissection or sentinel node biopsy...
December 26, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/29286917/protein-and-dna-evidences-of-hcmv-infection-in-primary-breast-cancer-tissues-and-metastatic-sentinel-lymph-nodes
#16
Jian Cui, Qian Wang, Hai-Bo Wang, Bin Wang, Ling Li
BACKGROUND AND OBJECTIVE: Breast cancer is the leading cause of death in women worldwide. There are evidences that human cytomegalovirus (HCMV) infection is associated with several malignant tumors. This study aims to investigate the infection of human cytomegalovirus (HCMV) in a large sample of breast cancer patients, and conduct a correlation analysis of clinical and pathological factors, to provide evidence for whether HCMV infection is associated with breast cancer development, progression and metastasis...
December 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/29285043/improved-model-for-predicting-axillary-response-to-neoadjuvant-chemotherapy-in-patients-with-clinically-node-positive-breast-cancer
#17
Hyung Suk Kim, Man Sik Shin, Chang Jong Kim, Sun Hyung Yoo, Tae Kyung Yoo, Yong Hwa Eom, Byung Joo Chae, Byung Joo Song
Purpose: Pathological complete response (pCR) of axillary lymph node (LN) is frequently achieved in patients with clinically node-positive breast cancer after neoadjuvant chemotherapy (NAC). Treatment of the axilla after NAC is not well established and the value of sentinel LN biopsy following NAC remains unclear. This study investigated the predictive value of axillary response following NAC and evaluated the predictive value of a model based on axillary response. Methods: Data prospectively collected on 201 patients with clinically node-positive breast cancer who were treated with NAC and underwent axillary LN dissection (ALND) were retrieved...
December 2017: Journal of Breast Cancer
https://www.readbyqxmd.com/read/29279156/the-impact-of-axillary-ultrasound-with-biopsy-in-overtreatment-of-early-breast-cancer
#18
Javier Del Riego, María Jesús Diaz-Ruiz, Milagros Teixidó, Judit Ribé, Mariona Vilagran, Lydia Canales, Melcior Sentís
PURPOSE: (a) To compare the axillary tumor burden detected by fine-needle aspiration cytology (FNAC) versus sentinel lymph node biopsy (SLNB). (b) To evaluate the relationship between axillary tumor burden and the number of suspicious lymph nodes detected by axillary ultrasonography (US). (c) To calculate the false-positive and false-negative rates for FNAC in patients fulfilling ACOSOG Z0011 criteria. METHODS: Retrospective multicenter cross-sectional study of 355 pT1 breast cancers...
January 2018: European Journal of Radiology
https://www.readbyqxmd.com/read/29273307/sentinel-lymph-node-biopsy-in-endometrial-cancer-feasibility-safety-and-lymphatic-complications
#19
Barbara Geppert, Céline Lönnerfors, Michele Bollino, Jan Persson
OBJECTIVE: To compare the rate of lymphatic complications in women with endometrial cancer undergoing sentinel lymph node biopsy versus a full pelvic and infrarenal paraaortic lymphadenectomy, and to examine the overall feasibility and safety of the former. METHODS: A prospective study of 188 patients with endometrial cancer planned for robotic surgery. Indocyanine green was used to identify the sentinel lymph nodes. In low-risk patients the lymphadenectomy was restricted to removal of sentinel lymph nodes whereas in high-risk patients also a full lymphadenectomy was performed...
December 20, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29260248/-chronic-refractory-ulcer-on-the-ring-finger-manifestation-of-distal-epithelioid-sarcoma
#20
N S Häring, R Strohal, S Dertinger, F Offner
The epithelioid sarcoma classic, "distal" type was first published in 1970. It is a very rare, malignant, aggressive subcutaneous soft tissue sarcoma that shows characteristic positivity for both epithelial and mesenchymal immunohistochemical markers. It grows very slowly and mostly presents in young men. Clinically the tumor is characterized as a coarse cutaneous or subcutaneous nodular induration that often ulcerates in the course of the disease. An association with trauma is often described and can lengthen time to diagnosis...
December 19, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
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