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sentinel node biopsy

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https://www.readbyqxmd.com/read/29780827/sentinel-lymph-node-biopsy-in-breast-cancer-patients-by-means-of-indocyanine-green-using-the-karl-storz-vitom%C3%A2-fluorescence-camera
#1
Thomas Papathemelis, Evi Jablonski, Anton Scharl, Tanja Hauzenberger, Michael Gerken, Monika Klinkhammer-Schalke, Matthias Hipp, Sophia Scharl
Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) for axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative sentinel lymph node (SLN) tracking agent. We evaluated the clinical value of ICG as an additional tracer in combination with Technetium99m and as an alternative to Technetium99m for the identification of SLN in 104 breast cancer patients. 21 patients had at least 1 histologically tumor-positive SLN. All 21 patients were detected by ICG; in one of these 21 sentinel-positive patients, Technetium99m was unable to identify lymph node involvement...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29776842/-risk-of-axillary-recurrence-after-sentinel-lymph-node-biopsy-before-neoadjuvant-chemotherapy-in-breast-cancer
#2
A Tardieu, C Mesnard, F Margueritte, J Mollard, A Lacorre, Y Aubard, E Deluche, T Gauthier
OBJECTIVES: In case of large breast cancer, neoadjuvant chemotherapy (NAC) can be performed to reduce the size of the tumor and thus perform a conservative surgery. The place of the sentinel lymph node biopsy (SLNB) in case of NAC is still debated. The main aim of this study is to assess the risk of axillary recurrence after negative SLNB before NAC. METHODS: It is a retrospective, observational and uni-centric study. We included 18 to 80-year-old patients with unilateral breast cancer requiring a NAC and with a negative SLNB before NAC...
May 15, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29774321/sentinel-lymph-node-metastasis-in-invasive-lobular-carcinoma-of-the-breast
#3
Hikmet Erhan Güven, Mahmut Onur Kültüroğlu, Mehmet Ali Gülçelik, Cihangir Özaslan
Objective: Invasive lobular carcinoma (ILC) of the breast makes up 5 to 15 percent of all invasive breast cancers. It has distinctive clinical and histopathological features when compared to invasive ductal carcinoma (IDC). This study intends to describe factors influencing sentinel lymph node (SLN) positivity in patients with "pure" ILC. Materials and Methods: Data of 105 patients, who were treated at a tertiary oncology center, with lobular carcinoma of the breast that were subjected to SLN biopsy was probed retrospectively...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29774318/biological-subtypes-of-breast-cancer-and-sentinel-lymph-node-biopsy
#4
Muhammet Kadri Çolakoğlu, Erhan Güven, Gökhan Giray Akgül, Lütfi Doğan, Mehmet Ali Gülçelik
Objective: Breast cancer subtypes are used as prognostic and predictive factors considering the genomic profile of the disease. This study is designed to investigate the Sentinel Lymph Node (SLN) detection rate in breast cancer for different biological characteristics. Material and Methods: Patients on whom we performed the methylene blue method alone were named as Group I, radiocolloid substance method alone as Group II and both methylene blue and radiocolloid method as Group III...
April 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/29770313/management-of-the-axilla-in-metaplastic-breast-carcinoma
#5
Brittany L Murphy, Robert T Fazzio, Tanya L Hoskin, Katrina N Glazebrook, Michael G Keeney, Elizabeth B Habermann, Tina J Hieken
Background: Metaplastic breast cancer (MBC), characterized by admixed epithelial, squamous or mesenchymal elements, constitutes <1% of breast cancers and has a poor prognosis but a paradoxically low reported rate of axillary lymph node (LN) involvement. Due to its rarity, data on appropriate axillary management is lacking, prompting this investigation of LN status and outcomes. Methods: We identified 41 MBC patients treated at our institution 2001-2011 who were followed for a median of 66 months...
April 2018: Gland Surgery
https://www.readbyqxmd.com/read/29766779/technetium-99m-based-radiopharmaceuticals-in-sentinel-lymph-node-biopsy-gynecologic-oncology-perspective
#6
Kamil Zalewski, Malgorzata Benke, Bartlomiej Mirocha, Jakub Radziszewski, Magdalena Chechlinska, Magdalena Kowalewska
Technetium (99mTc)-radiolabeled colloids are popular tracers used to map lymphatic vessels and regional lymph nodes (LNs). The regional LN status is a significant determinant of cancer stage and patient prognosis, and strongly influences treatment. Regional LN dissection has become part of surgical treatment. However, not all patients with LN involvement benefit from extensive lymphadenectomy in terms of prolonged survival. Moreover, overtreatment of patients with localized disease carries unnecessary risk of complications...
May 15, 2018: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29762449/time-to-procedure-nuclear-imaging-and-clinicopathological-characteristics-as-predictive-factors-for-sentinel-lymph-node-metastasis-in-cutaneous-melanoma-a-single-center-analysis
#7
Ljiljana Jaukovic, Milica Rajović, Lidija Kandolf Sekulovic, Marija Radulovic, Nenad Stepic, Zeljko Mijuskovic, Nenad Petrov, Boris Ajdinovic
OBJECTIVE: Sentinel lymph node (SLN) biopsy is a widely accepted staging procedure for cutaneous melanoma patients who are at risk of clinically occult nodal metastases. Numerous predictive factors for regional lymph node metastases have been identified; however, few have been found to be reproducibly significant. Also, the role of blue dye in identification was questioned in recent trials. Time to procedure was also found to be predictive of SLN positivity, but this was not confirmed in other studies...
May 14, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29757871/influence-of-prognostic-factors-on-lymph-node-involvement-in-endometrial-cancer-a-single-center-experience
#8
Peter Widschwendter, Emanuel Bauer, Nikolaus De Gregorio, Inga Bekes, Wolfgang Janni, Christoph Scholz, Thomas W P Friedl
OBJECTIVE: The requirement for and extent of lymphadenectomy in endometrial cancer is still controversial. Clinicopathological prognostic factors could be helpful to predict lymph node involvement and avoid therefore unnecessary lymphadenectomy. The aim of this study was to investigate which factors can predict lymph node involvement and how lymph node metastases are distributed in the pelvic and para-aortic regions. METHODS: This retrospective analysis was performed by analyzing data from patients with endometrial cancer treated with standard surgery and lymphadenectomy at the Department of Gynecology and Obstetrics of the University Hospital Ulm in 2000 to 2013...
May 11, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29756115/severe-decrease-in-spo-2-and-methemoglobinemia-following-subareolar-isosulfan-blue-administration-and-clinical-relevance
#9
Esra Yüksel, Dilek Duman, Levent Yeniay, Sezgin Ulukaya
The level of axillary lymph node involvement in breast cancer is a critical decision factor for adjuvant therapy and the most important indicator of prognosis and survival. Sentinel lymph node biopsy is a minimally invasive technique with low morbidity in axillary staging of breast cancer. Radiocolloid substances (Technetium-99m) and/or blue dyes such as methylene blue or isosulfan blue are used during sentinel lymph node biopsy. Isosulfan blue stain is frequently used in sentinel lymph node biopsy and rarely causes complications...
2018: Turkish Journal of Surgery
https://www.readbyqxmd.com/read/29755118/tumour-mutation-status-and-melanoma-recurrence-following-a-negative-sentinel-lymph-node-biopsy
#10
Nikki R Adler, Rory Wolfe, Grant A McArthur, John W Kelly, Andrew Haydon, Catriona A McLean, Victoria J Mar
BACKGROUND: A proportion of patients develop recurrence following a tumour-negative sentinel lymph node biopsy (SLNB). This study aimed to explore whether melanoma patients with BRAF or NRAS mutant tumours have an increased risk of developing disease recurrence following a negative SLNB compared to patients with wild-type tumours. METHODS: Prospective cohort study of melanoma patients at three tertiary referral centres in Melbourne, who underwent SLNB. Clinical, pathological and molecular characteristics and recurrence data were prospectively recorded...
May 14, 2018: British Journal of Cancer
https://www.readbyqxmd.com/read/29746624/contemporary-evaluation-of-breast-lymph-nodes-in-anatomic-pathology
#11
Beth T Harrison, Jane E Brock
Objectives: Management of the axilla in breast cancer patients has evolved considerably since the introduction of the sentinel lymph node (SLN) biopsy in the 1990s. Several new clinical and technological developments in the last decade warrant special consideration due to their impact on pathology practice. Methods: This review covers the SLN biopsy procedure, issues in the histopathologic and molecular diagnosis of the SLN, and most importantly, evidence from recent practice-changing clinical trials...
May 9, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29745094/predictors-of-sentinel-lymph-node-status-of-cutaneous-melanoma-in-serbian-patients
#12
Stevan Jokic, Ivan Markovic, Zoran Bukumiric, Vladimir Jokic, Marija Rakovic, Jovana Tripkovic, Dejan Stojiljkovic, Igor Spurnic, Marko Jevric, Marija Matic, Danijela Dobrosavljevic
PURPOSE: Presence of metastasis in sentinel lymph node (SLN) is considered to be the most important factor in terms of patient survival. The main aim of this study was to identify predictors of positive SLN in Serbian patients with melanoma. METHODS: This retrospective study was conducted on 147 patients. Univariate chi-square and univariate logistic regression analyses were used to identify the association between prognostic factors and positive SLN. Receiver Operating Characteristics (ROC) was conducted to find the Breslow thickness cutoff point at which to perform SLN biopsy (SLNB)...
March 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29744670/real-time-navigation-system-for-sentinel-lymph-node-biopsy-in-breast-cancer-patients-using-projection-mapping-with-indocyanine-green-fluorescence
#13
Masahiro Takada, Megumi Takeuchi, Eiji Suzuki, Fumiaki Sato, Yoshiaki Matsumoto, Masae Torii, Nobuko Kawaguchi-Sakita, Hiroto Nishino, Satoru Seo, Etsuro Hatano, Masakazu Toi
BACKGROUND: Inability to visualize indocyanine green fluorescence images in the surgical field limits the application of current near-infrared fluorescence imaging (NIR) systems for real-time navigation during sentinel lymph node (SLN) biopsy in breast cancer patients. The aim of this study was to evaluate the usefulness of the Medical Imaging Projection System (MIPS), which uses active projection mapping, for SLN biopsy. METHODS: A total of 56 patients (59 procedures) underwent SLN biopsy using the MIPS between March 2016 and November 2017...
May 9, 2018: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29742186/factors-affecting-dermatologists-use-of-a-31-gene-expression-profiling-test-as-an-adjunct-for-predicting-metastatic-risk-in-cutaneous-melanoma
#14
Ryan M Svoboda, Alex M Glazer, Aaron S Farberg, Darrell S Rigel
IMPORTANCE: A 31-gene expression profile (31-GEP) test to predict metastatic risk in patients with cutaneous malignant melanoma has previously been validated and is available for clinical use. The impact of the availability of such a test on clinical decision-making has previously been studied. However, little is known about which factors play a role in clinicians' decision to utilize the test. OBJECTIVE: To determine factors affecting clinicians' decisions to utilize the 31-GEP test for metastatic risk stratification in patients with cutaneous malignant melanoma...
May 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29735384/sentinel-lymph-node-biopsy-in-malignant-melanoma-of-the-head-and-neck
#15
Roman Kia Rahimi-Nedjat, Bilal Al-Nawas, Andrea Tuettenberg, Keyvan Sagheb, Stephan Grabbe, Christian Walter
BACKGROUND: The aim of this retrospective study was to investigate sentinel lymph node biopsy in patients with head and neck melanoma. MATERIALS AND METHODS: Patients who underwent SLNB between 2010 and 2016 were comprised. Epidemiological, radiological, and surgical data were collected and compared to histological findings. Patients who underwent primary complete lymph node dissection were excluded. RESULTS: 74 patients underwent SLNB during this period...
April 12, 2018: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29732093/diketopyrrolopyrrole-based-semiconducting-polymer-nanoparticles-for-in-vivo-second-near-infrared-window-imaging-and-image-guided-tumor-surgery
#16
Kangquan Shou, Yufu Tang, Hao Chen, Si Chen, Lei Zhang, Ao Zhang, Quli Fan, Aixi Yu, Zhen Cheng
A diketopyrrolopyrrole-based semiconducting polymer nanoparticle (PDFT1032) has been developed as a NIR-II (near infrared window II, 1000-1700 nm) fluorescent probe. It shows high photostability, a favorable absorption peak at 809 nm, a large Stokes shift of 223 nm, outstanding biocompatibility and minimal in vivo toxicity. More importantly, the versatile use of PDFT1032 for several important biomedical applications in the NIR-II window has been demonstrated, including the NIR-II optical imaging of tumors on a subcutaneous osteosarcoma model, assessing the vascular embolization therapy of tumors, and NIR-II image-guided orthotopic tumor surgery and sentinel lymph node biopsy (SLNB) with high spatial and temporal resolution...
March 28, 2018: Chemical Science
https://www.readbyqxmd.com/read/29730916/-the-influence-of-lumpectomy-on-the-axillary-lymph-node-status-of-breast-cancer-patients
#17
D C Jiao, J J Zhu, J H Qiao, L N Wang, Y Z Ma, Z D Lu, Z Z Liu
Objective: To investigate the influence of lumpectomy on axillary lymph node status of breast cancer patients. Methods: The clinical data of 738 invasive breast cancer patients with non-palpable axillary lymph node and sentinel lymph node (SLN) biopsy from November 2011 to August 2013 in Henan Provincial Cancer Hospital were collected and retrospectively analyzed. Among them, 136 patients underwent preoperative lumpectomy (lumpectomy group) and 602 patients underwent puncture biopsy only (biopsy group). The difference of axillary lymph node status and positive ratio of SLN detected by color Doppler ultrasound were compared between these two groups...
April 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29721480/practical-consensus-recommendations-regarding-the-management-of-sentinel-lymph-node-issues-in-early-breast-cancer
#18
Vedant Kabra, R Aggarwal, S Vardhan, M Singh, R Khandelwal, S Jain, S Sahani, S Saini, N Deo, R Kaul, P M Parikh, S Aggarwal
Axillary lymph node involvement is a very important poor prognostic factor in the clinical staging and management of breast cancer patients. Traditionally, axillary lymph node dissection (ALND) has been used for determining the status of the axillary lymph nodes. More recently the sentinel lymph node biopsy (SLNB) procedure has gained wider acceptance as the standard of care, having the advantage of being less invasivewhile providing good accuracy. This expert group used data from published literature, practical experience and opinion of a large group of academic oncologists to arrive at these practical consensus recommendations in regards with the use of the two different procedures and other issues in patients with early breast cancer for the benefit of community oncologists...
April 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29719827/sentinel-node-biopsy-in-melanoma-a-short-update
#19
REVIEW
Gerardo Ferrara, Antonietta Partenzi, Alessandra Filosa
Several controversies are still ongoing about sentinel node biopsy in melanoma. It is basically a staging procedure for melanoma > 0.75 mm in thickness or for thinner melanoma in the presence of ulceration, high mitotic rate, and/or lymphovascular invasion. Complete lymph node dissection after a positive sentinel node can also allow a better locoregional disease control but seems not to prevent the development of distant metastases. The use of sentinel node biopsy in atypical Spitz tumors should be discouraged because of their peculiar biological properties...
January 2018: Dermatopathology (Basel, Switzerland)
https://www.readbyqxmd.com/read/29719391/combined-use-of-fluorescence-with-a-magnetic-tracer-and-dilution-effect-upon-sentinel-node-localization-in-a-murine-model
#20
Akihiro Kuwahata, Muneer Ahmed, Kohei Saeki, Shinichi Chikaki, Miki Kaneko, Wenqi Qiu, Zonghao Xin, Shinji Yamaguchi, Akiko Kaneko, Michael Douek, Moriaki Kusakabe, Masaki Sekino
Background: Sentinel node biopsy using radioisotope and blue dye remains a gold standard for axillary staging in breast cancer patients with low axillary burden. However, limitations in the use of radioisotopes have resulted in emergence of novel techniques. This is the first in vivo study to assess the feasibility of combining the two most common novel techniques of using a magnetic tracer and indocyanine green (ICG) fluorescence. Materials and methods: A total of 48 mice were divided into eight groups...
2018: International Journal of Nanomedicine
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