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https://www.readbyqxmd.com/read/29783260/-methods-of-diagnosis-of-non-specific-and-specific-lymphideniates-of-the-jaw-facial-part-in-children-literature-review
#1
Pavlo I Tkachenko, Yurii B Lobach, Sergii O Bilokon, Vitalina O Dobroskok, Yuliia V Popelo
OBJECTIVE: Introduction: Insufficient basic knowledge on the mechanisms of the multifactoral etiology and pathogenesis of various forms of maxillofacial lymphadenitis of odontogenic and non-odontogenic nature in children causes difficulties in making differential diagnosis. The algorithm of their examination involves a large number of methods, each of which has its own advantages and disadvantages with variable informativeness, depending on the particular situation. The aim: The paper is aimed atfamiliarization of broad medical public with informativeness of diagnostic measures in the nonspecific and specific affection of lymph nodes of the maxillofacial area in children...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29783070/cdh17-alters-mmp-2-expression-via-canonical-nf-%C3%AE%C2%BAb-signalling-in-human-gastric-cancer
#2
Xiao-Jie Jiang, Jing Lin, Qing-He Cai, Jian-Feng Zhao, Hui-Jiao Zhang
Gastric cancer (GC), one of the most common cancers of the digestive system, results in high morbidity and mortality, but the molecular mechanisms underlying GC remain largely unknown. Cadherin-17 (CDH17) is a nonclassical member of the cadherin (CDH) superfamily of calcium-dependent proteins. Despite recent advances in the understanding of CDH17 biology, the mechanism of CDH17 in GC proliferation, migration, and invasion has not been extensively studied. In the present study, we observed that CDH17 expression was increased in GC tissues compared with para-carcinoma tissues and was correlated with lymph node metastasis and the AJCC stage...
May 18, 2018: Gene
https://www.readbyqxmd.com/read/29783028/thoracic-duct-embolization-a-survey-of-practice-patterns
#3
Samantha A Jayasinghe, Ravi N Srinivasa, Anthony N Hage, Joseph J Gemmete, Bill S Majdalany, Jeffrey Forris Beecham Chick
PURPOSE: To determine training, treatment techniques, outcomes, and practice patterns of practitioners performing thoracic duct embolization (TDE). MATERIALS AND METHODS: From September to October of 2017, a 34-question survey focusing on training, treatment techniques, outcomes, and practice patterns of TDE was distributed through the Open Forum using the Society of Interventional Radiology Connect website. 54 practitioners completed the entire survey. Percentages were calculated for answers to the questions...
May 18, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29783001/laparoscopic-extraperitoneal-pelvic-lymph-node-debulking-in-locally-advanced-cervical-cancer
#4
Diaz-Feijoo Berta, Luna-Guibourg Rocio, Cabrera Silvia, Manrique Susana, Gil-Moreno Antonio
OBJECTIVE: To demonstrate the feasibility of laparoscopic extraperitoneal approach for pelvic metastatic lymph node debulking in locally advanced cervical cancer. DESIGN: Surgical video article. Canadian task force Classification III. SETTING: University Hospital PATIENT: A 52 year-old patient presented a stage IIA2 Cervical adenocarcinoma according to FIGO classification. The physical exam reported a 45 mm tumor. Positron emission tomography (PET- CT) was positive for hypermetabolic enlarged lymph nodes in left external iliac region of 1...
May 18, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29782363/regional-lymph-node-metastases-in-groin-sarcomas-a-diagnostic-and-therapeutic-challenge
#5
Deanna Wan Jie Ng, Ye Xin Koh, Grace Hwei Ching Tan, Khee Chee Soo, Melissa Ching Ching Teo
INTRODUCTION: The evaluation of lymph nodes and the role of groin dissection for groin sarcomas has been controversial where there have not been previous studies or guidelines published. In this study, we aim to first formulate a clinical approach in the evaluation of regional lymph nodal metastases. Second, we aim to also evaluate the role of regional lymphadenectomy in the setting of pathologically involved regional lymph nodes for groin sarcomas. MATERIALS AND METHODS: In total, 43 consecutive patients with groin sarcomas underwent treatment at the National Cancer Centre Singapore between 2002 and 2015...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782362/breast-conservation-therapy-after-neoadjuvant-chemotherapy-does-not-compromise-10-year-breast-cancer-specific-mortality
#6
Renee L Arlow, Lisa E Paddock, Xiaoling Niu, Laurie Kirstein, Bruce G Haffty, Sharad Goyal, Thomas Kearney, Deborah Toppmeyer, Antoinette M Stroup, Atif J Khan
OBJECTIVES: Neoadjuvant chemotherapy can increase the rate of breast-conserving surgery by downstaging disease in patients with breast cancer. The aim of this study was to determine whether patients who received neoadjuvant chemotherapy have equal survival after breast-conservation therapy compared with mastectomy. MATERIAL AND METHODS: Using the New Jersey State Cancer Registry (NJSCR) patients with a primary breast cancer diagnosed between 1998 and 2003 who underwent neoadjuvant chemotherapy were selected (n=1,468)...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782361/the-significance-of-para-aortic-nodal-size-and-the-role-of-adjuvant-systemic-chemotherapy-in-cervical-cancer-an-institutional-experience
#7
Dustin B Manders, Travis T Sims, April Bailey, Lindsay Hwang, Debra L Richardson, David S Miller, Siobhan M Kehoe, Kevin V Albuquerque, Jayanthi S Lea
OBJECTIVE: Cervical cancer metastatic to the para-aortic lymph nodes (PALNs) carries a poor prognosis. Despite extended-field radiation therapy (EFRT), only 30% to 50% of patients will survive 3 years. We sought to examine the treatment regimens used, associated toxicities, and treatment outcomes in patients with cervical cancer metastatic to PALN. METHODS: A retrospective review was performed of all patients with cervical cancer treated at a single institution between January 1, 2007 and November 1, 2014...
May 18, 2018: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29782301/lymphangioma-circumscriptum-post-radiotherapy-for-penile-cancer-treated-with-co%C3%A2-laser
#8
Dietmar Schulz, Andreas Lein, Ancuta Proca Nicula, Katrin Schierle, Caius Solovan
Lymphangioma circumscriptum (LC) is a rare, benign condition, predominantly characterized by the malformation of lymphatic skin vessels. Its onset may be congenital or due to secondary causes such as radiotherapy, infections, or surgical procedures. We present the case of a 55-year-old patient with a pathologic history of squamous cell carcinoma of the penis followed by radical penectomy. Due to metastasis to the locoregional lymph nodes, the entire affected area was subsequently treated with radiation therapy, receiving a total dose of 55...
April 2018: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/29781858/axillary-lymphadenectomy-and-wound-complications-in-implant-based-breast-reconstruction
#9
Matthew T Joy, Matthew D Rich, Kurtis E Moyer
BACKGROUND: The most common method of breast reconstruction in the United States today is implant-based reconstruction. However, reported complication rates are high, from 30% to 50%. Thus, it is important for reconstructive surgeons to identify factors associated with or contributing to wound complications after breast reconstruction. This study sought to identify associations between axillary lymph node dissection and postoperative wound complications in implant-based breast reconstruction...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29781815/lymph-node-fibrosis-a-structural-barrier-to-unleashing-effective-vaccine-immunity
#10
Boris Julg, Galit Alter
There is marked variability in vaccine efficacy among global populations. In particular, individuals in low- to middle-income countries have been shown to be less responsive to vaccines than those from developed nations. Several factors, including endemic infections, nutrition, genetics, and gut microbiome composition, have been proposed to underlie discrepancies in vaccine response. In this issue of the JCI, Kityo et al. evaluated response to yellow fever virus vaccine, inflammation, and lymphatic tissue architecture and fibrosis in three cohorts: two from the U...
May 21, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29781814/lymphoid-tissue-fibrosis-is-associated-with-impaired-vaccine-responses
#11
Cissy Kityo, Krystelle Nganou Makamdop, Meghan Rothenberger, Jeffrey G Chipman, Torfi Hoskuldsson, Gregory J Beilman, Bartosz Grzywacz, Peter Mugyenyi, Francis Ssali, Rama S Akondy, Jodi Anderson, Thomas E Schmidt, Thomas Reimann, Samuel P Callisto, Jordan Schoephoerster, Jared Schuster, Proscovia Muloma, Patrick Ssengendo, Eirini Moysi, Constantinos Petrovas, Ray Lanciotti, Lin Zhang, Maria T Arévalo, Benigno Rodriguez, Ted M Ross, Lydie Trautmann, Rafick-Pierre Sekaly, Michael M Lederman, Richard A Koup, Rafi Ahmed, Cavan Reilly, Daniel C Douek, Timothy W Schacker
Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection...
May 21, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29781755/more-robust-gut-immune-responses-induced-by-combining-intranasal-and-sublingual-routes-for-prime-boost-immunization
#12
Hye Suk Hwang, Sao Puth, Wenzhi Tan, Vivek Verma, Kwangjoon Jeong, Shee Eun Lee, Joon Haeng Rhee
Norovirus causes acute and debilitating gastroenteritis, characterized by vomiting and diarrhea. We recently reported a recombinant GII. 4 P domain particle (Pd) vaccine adjuvanted with a flagellin, Vibrio vulnificus FlaB, effectively promoting both humoral and cell-mediated immune responses. In the previous study, we found that sublingual (SL) immunization induced higher fecal secretory IgA (SIgA) responses while intranasal (IN) route provided higher amplitude of humoral and cellular immune responses in the systemic compartment...
May 21, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29781567/localized-vaginal-uterine-rhabdomyosarcoma-results-of-a-pooled-analysis-from-four-international-cooperative-groups
#13
Veronique Minard-Colin, David Walterhouse, Gianni Bisogno, Helene Martelli, James Anderson, David A Rodeberg, Andrea Ferrari, Meriel Jenney, Suzanne Wolden, Gianluca De Salvo, Carola Arndt, Johannes H M Merks, Soledad Gallego, Dominique Schwob, Christine Haie-Meder, Christophe Bergeron, Michael C G Stevens, Odile Oberlin, Douglas Hawkins
BACKGROUND: Vaginal/uterine rhabdomyosarcoma (VU RMS) is one of the most favorable RMS sites. To determine the optimal therapy, the experience of four cooperative groups (Children's Oncology Group [COG], International Society of Pediatric Oncology (SIOP) Malignant Mesenchymal Tumor Group [MMT], Italian Cooperative Soft Tissue Sarcoma Group [ICG], and European pediatric Soft tissue sarcoma Study Group [EpSSG]) was analyzed. PROCEDURE: From 1981 to 2009, 237 patients were identified...
May 21, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29781204/malignant-melanoma-with-osteosarcomatous-differentiation-in-a-lymph-node-metastasis
#14
Jasmine Saleh, Michael L Wang, Paul W Harms, Rajiv M Patel, Douglas R Fullen
Osteocartilaginous differentiation in malignant melanoma is rare and can pose a diagnostic challenge. In previously reported cases, melanomas were predominantly located on acral and mucosal sites with osteocartilaginous differentiation present in either primary or recurrent lesions. We report a case of a 52-year-old female with malignant melanoma located on the right upper back exhibiting osteosarcomatous differentiation only in the axillary lymph node metastasis. This case serves to highlight that the divergent differentiation can occur in lymph node metastases while being absent in the primary lesion...
May 20, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29781094/a-new-model-to-predict-risk-of-nonsentinel-lymph-node-status-in-chinese-sentinel-lymph-node-positive-patients-after-neoadjuvant-chemotherapy
#15
Yang Yang, Yingjian He, Zhaoqing Fan, Yiqiang Liu, Tao Ouyang
There is no previous predictive model to assess risk of nonsentinel lymph node metastases (NSLN) in sentinel lymph node (SLN)-positive breast cancer patients after neoadjuvant chemotherapy (NAT). Our goal was to develop a new predictive model for SLN-positive patients after NAT, and validate this new model. A series of 513 patients with metastases in SLN who received NAT were used to evaluate factors affecting NSLN status. Logistic regression analysis was performed to develop a predictive model, which was validated by a subsequent prospective 138 patients...
May 20, 2018: Breast Journal
https://www.readbyqxmd.com/read/29781037/microrna-485-plays-tumour-suppressive-roles-in-colorectal-cancer-by-directly-targeting-gab2
#16
Jibin Li, Jian Xu, Xiaofei Yan, Keer Jin, Wenya Li, Rui Zhang
Colorectal cancer (CRC) is reported to be the third most common cancer and the fourth leading cause of cancer-related deaths around the world. MicroRNA-485 (miR-485) has been reported to be aberrantly expressed and play important roles in several types of human malignancy. However, the expression level, biological functions and underlying molecular mechanisms of miR-485 in CRC remain unclear. Therefore, the aim of the present study was to determine miR-485 expression levels and their clinical significance in CRC and to explore the functions and underlying mechanisms of miR-485 in this disease...
May 17, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29780827/sentinel-lymph-node-biopsy-in-breast-cancer-patients-by-means-of-indocyanine-green-using-the-karl-storz-vitom%C3%A2-fluorescence-camera
#17
Thomas Papathemelis, Evi Jablonski, Anton Scharl, Tanja Hauzenberger, Michael Gerken, Monika Klinkhammer-Schalke, Matthias Hipp, Sophia Scharl
Currently, the use of radioisotope and blue dye for sentinel lymph node biopsy (SLNB) for axillary staging in breast cancer is common. Recently, indocyanine green (ICG) has been proposed as an alternative sentinel lymph node (SLN) tracking agent. We evaluated the clinical value of ICG as an additional tracer in combination with Technetium99m and as an alternative to Technetium99m for the identification of SLN in 104 breast cancer patients. 21 patients had at least 1 histologically tumor-positive SLN. All 21 patients were detected by ICG; in one of these 21 sentinel-positive patients, Technetium99m was unable to identify lymph node involvement...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780717/robotic-internal-mammary-lymphadenectomy-another-possible-minimally-invasive-approach-to-sampling-lymph-nodes-in-breast-cancer-patients
#18
Alessandro Pardolesi, Luca Bertolaccini, Jury Brandolini, Piergiorgio Solli
Internal mammary lymphadenopathy may develop in breast cancer patients with silicone implants. Differential diagnosis includes malignant recurrence, infections, inflammations and granulomatous deposit. We report a case of internal mammary lymphadenopathy, in a patient with the previous history of breast cancer, requiring a tissue diagnosis. We performed a Robotic lymph nodes dissection of the left internal mammary. Final pathology diagnosis was positive for silicone granulomatous lymphadenitis secondary to silicone breast implants inserted after mastectomy for breast cancer...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29780627/a-new-approach-to-predict-lymph-node-metastasis-in-solid-lung-adenocarcinoma-a-radiomics-nomogram
#19
Xinguan Yang, Xiaohuan Pan, Hui Liu, Dashan Gao, Jianxing He, Wenhua Liang, Yubao Guan
Background: Lymph node metastasis (LNM) of lung cancer is an important factor related to survival and recurrence. The association between radiomics features of lung cancer and LNM remains unclear. We developed and validated a radiomics nomogram to predict LNM in solid lung adenocarcinoma. Methods: A total of 159 eligible patients with solid lung adenocarcinoma were divided into training (n=106) and validation cohorts (n=53). Radiomics features were extracted from venous-phase CT images...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780255/predicting-initial-margin-status-in-breast-cancer-patients-during-breast-conserving-surgery
#20
Zihao Pan, Liling Zhu, Qian Li, Jianguo Lai, Jingwen Peng, Fengxi Su, Shunrong Li, Kai Chen
Background: We sought to develop and validate a model for prediction of initial margin status during breast-conserving surgery (BCS). Methods: We included eligible breast cancer patients receiving BCS in Sun Yat-sen Memorial Hospital from January 2003 to December 2014. All patients received intraoperative frozen-section analysis for initial margin assessment. We used univariate and multivariate logistic regression analyses to screen for predictors. A nomogram was developed in the training cohort (n=1,193) from the south branch of the hospital and externally validated in the validation cohort (n=499) from the north branch...
2018: OncoTargets and Therapy
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