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https://www.readbyqxmd.com/read/28322628/a-critical-review-of-the-relationship-between-occupational-exposure-to-diesel-emissions-and-lung-cancer-risk
#1
Matthias Möhner, Andrea Wendt
In 2012, a working group of the International Agency for Research on Cancer classified diesel exhaust (DE) as a human carcinogen (Group 1). This decision was primarily based on the findings of the Diesel Exhaust in Miners Study (DEMS). The disparity between the results of various methodological approaches applied to the DEMS led to several critical commentaries. An expert panel was subsequently set up by the Health Effects Institute to evaluate the DEMS results, together with a large study in the trucking industry...
March 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28319172/correction-identification-of-potential-novel-biomarkers-and-signaling-pathways-related-to-otitis-media-induced-by-diesel-exhaust-particles-using-transcriptomic-analysis-in-an-in-vivo-system
#2
Hyo Jeong Kim, So Young Kim, Jee Young Kwon, Yeo Jin Kim, Seung Hun Kang, Won-Hee Jang, Jun Ho Lee, Myung-Whan Suh, Jae-Jun Song, Young Rok Seo, Moo Kyun Park
[This corrects the article DOI: 10.1371/journal.pone.0166044.].
2017: PloS One
https://www.readbyqxmd.com/read/28315692/role-of-epithelial-mesenchymal-transition-emt-and-fibroblast-function-in-cerium-oxide-nanoparticles-induced-lung-fibrosis
#3
Jane Ma, Bridget Bishoff, R R Mercer, Mark Barger, Diane Schwegler-Berry, Vincent Castranova
The emission of cerium oxide nanoparticles (CeO2) from diesel engines, using cerium compounds as a catalyst to lower the diesel exhaust particles, is a health concern. We have previously shown that CeO2 induced pulmonary inflammation and lung fibrosis. The objective of the present study was to investigate the modification of fibroblast function and the role of epithelial-mesenchymal transition (EMT) in CeO2-induced fibrosis. Male Sprague-Dawley rats were exposed to CeO2 (0.15 to 7mg/kg) by a single intratracheal instillation and sacrificed at various times post-exposure...
March 15, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28315615/mir155-regulation-of-ubiquilin1-and-ubiquilin2-implications-in-cellular-protection-and-tumorigenesis
#4
Sanjay Yadav, Nishant Singh, Parag P Shah, David A Rowbotham, Danial Malik, Ankita Srivastav, Jai Shankar, Wan L Lam, William W Lockwood, Levi J Beverly
Ubiquilin (UBQLN) proteins are adaptors thought to link ubiquitinated proteins to the proteasome. However, our lab has recently reported a previously unappreciated role for loss of UBQLN in lung cancer progression. In fact, UBQLN genes are lost in over 50% of lung cancer samples examined. However, a reason for the loss of UBQLN has not been proposed, nor has a selective pressure that could lead to deletion of UBQLN been reported. Diesel Exhaust Particles (DEP) are a major concern in the large cities of developing nations and DEP exposed populations are at an increased risk of developing a number of illnesses, including lung cancer...
March 15, 2017: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/28304344/nrf2-regulates-the-risk-of-a-diesel-exhaust-inhalation-induced-immune-response-during-bleomycin-lung-injury-and-fibrosis-in-mice
#5
Ying-Ji Li, Takako Shimizu, Yusuke Shinkai, Yukiyo Hirata, Hirofumi Inagaki, Ken Takeda, Arata Azuma, Masayuki Yamamoto, Tomoyuki Kawada
The present study investigated the effects of diesel exhaust (DE) on an experimental model of bleomycin (BLM)-induced lung injury and fibrosis in mice. BLM was intravenously administered to both Nrf2(+/+) and Nrf2(-/-) C57BL/6J mice on day 0. The mice were exposed to DE for 56 days from 28 days before the BLM injection to 28 days after the BLM injection. Inhalation of DE induced significant inhibition of airway clearance function and the proinflammatory cytokine secretion in macrophages, an increase in neutrophils, and severe lung inflammatory injury, which were greater in Nrf2(-/-) mice than in Nrf2(+/+) mice...
March 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28278030/carbon-nanotube-like-materials-in-the-exhaust-from-a-diesel-engine-using-gas-oil-ethanol-mixing-fuel-with-catalysts-and-sulphur
#6
Shunsuke Suzuki, Shinsuke Mori
Particle matters from a diesel engine including soot and carbon nanomaterials were collected on a sampling holder and their structure was studied by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). As a result of employing gas oil/ethanol mixing fuel with sulphur and ferrocene/molybdenum as catalyst sources, formation of carbon nanotubes (CNT)-like materials in addition to soot was observed in the exhaust gas from a diesel engine. It was revealed that CNT-like materials were included among soot in our system only when following three conditions were satisfied simultaneously; high ethanol fraction in fuel, high sulphur loading and presence of catalyst sources in fuel...
February 28, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28264691/endothelial-responses-of-the-alveolar-barrier-in-vitro-in-a-dose-controlled-exposure-to-diesel-exhaust-particulate-matter
#7
Sebastian G Klein, Sébastien Cambier, Jennifer Hennen, Sylvain Legay, Tommaso Serchi, Inge Nelissen, Aline Chary, Elisa Moschini, Andreas Krein, Brunhilde Blömeke, Arno C Gutleb
BACKGROUND: During the last 250 years, the level of exposure to combustion-derived particles raised dramatically in western countries, leading to increased particle loads in the ambient air. Among the environmental particles, diesel exhaust particulate matter (DEPM) plays a special role because of its omnipresence and reported effects on human health. During recent years, a possible link between air pollution and the progression of atherosclerosis is recognized. A central effect of DEPM is their impact on the endothelium, especially of the alveolar barrier...
March 6, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28259510/comparison-of-inflammatory-cytokine-release-from-nasal-epithelial-cells-of-non-atopic-non-rhinitic-allergic-rhinitic-and-polyp-subjects-and-effects-of-diesel-exhaust-particles-in-vitro
#8
A B Ozturk, R Bayraktar, B Gogebakan, S Mumbuc, H Bayram
BACKGROUND: Although studies have reported an association between air pollutants and increased allergic airway diseases, such as allergic rhinitis and nasal polyposis, the underlying mechanisms are not fully understood. A limited number of studies have suggested that diesel exhaust particles (DEP) play a role in atopy and the pathogenesis of allergic upper airway diseases. The aim of this study was to investigate the effect of DEP on inflammatory cytokine release, and mRNA expression of transcription factors such as JNK and NF-β in primary nasal epithelial cells (NECs), in vitro...
March 2, 2017: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/28230356/assessment-of-particle-pollution-from-jetliners-from-smoke-visibility-to-nanoparticle-counting
#9
Lukas Durdina, Benjamin T Brem, Ari Setyan, Frithjof Siegerist, Theo Rindlisbacher, Jing Wang
Aviation is a substantial and a fast growing emissions source. Besides greenhouse gases, aircraft engines emit black carbon (BC), a climate forcer and air pollutant. Aviation BC emissions have been regulated and estimated through exhaust smoke visibility (smoke number). Their impacts are poorly understood because emission inventories lack representative data. Here, we measured BC mass and number-based emissions of the most popular airliner's engines according to a new emission standard. We used a calibrated engine performance model to determine the emissions on the ground, at cruise altitude, and over entire flight missions...
March 6, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28218700/comparative-study-of-different-methods-for-soot-sensing-and-filter-monitoring-in-diesel-exhausts
#10
Markus Feulner, Gunter Hagen, Kathrin Hottner, Sabrina Redel, Andreas Müller, Ralf Moos
Due to increasingly tighter emission limits for diesel and gasoline engines, especially concerning particulate matter emissions, particulate filters are becoming indispensable devices for exhaust gas after treatment. Thereby, for an efficient engine and filter control strategy and a cost-efficient filter design, reliable technologies to determine the soot load of the filters and to measure particulate matter concentrations in the exhaust gas during vehicle operation are highly needed. In this study, different approaches for soot sensing are compared...
February 18, 2017: Sensors
https://www.readbyqxmd.com/read/28166626/in-use-nox-emissions-from-diesel-and-liquefied-natural-gas-refuse-trucks-equipped-with-scr-and-twc-respectively
#11
Chandan Misra, Chris Ruehl, John Francis Collins, Don Chernich, Jorn Herner
The California Air Resources Board (ARB) and the City of Sacramento undertook this study to characterize the in-use emissions from model year (MY) 2010 or newer diesel, liquefied natural gas (LNG) and hydraulic hybrid diesel engines during real-world refuse truck operation. Emissions from five trucks: two diesels equipped with selective catalytic reduction (SCR), two LNG's equipped with three-way catalyst (TWC) and one hydraulic hybrid diesel equipped with SCR were measured using a portable emissions measurement system (PEMS) in the Sacramento area...
February 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28166462/comparison-of-personal-diesel-and-biodiesel-exhaust-exposures-in-an-underground-mine
#12
Eric A Lutz, Rustin J Reed, Vivien S T Lee, Jefferey L Burgess
OBJECTIVE: This study aimed to compare personal exposures to diesel fuel and a biodiesel blend exhaust in an underground mine. METHODS: Personal exposure monitoring was performed in a non-operational, hard rock underground mine during use of a load-haul-dump vehicle. Eight-hour time-weighted average (TWA8) exposure concentrations of ultra-low sulfur diesel and 75% biodiesel/25% diesel blend (B75) fuels were compared. RESULTS: Compared to diesel, use of B75 was associated with relative percent reductions of 22 and 28% in median respirable (r) diesel particulate matter (DPM) and nitrogen dioxide and 25 and 23% increases in median total DPM and nitric oxide TWA8 exposure concentrations, respectively...
February 6, 2017: Journal of Occupational and Environmental Hygiene
https://www.readbyqxmd.com/read/28152992/absence-of-multiplicative-interactions-between-occupational-lung-carcinogens-and-tobacco-smoking-a-systematic-review-involving-asbestos-crystalline-silica-and-diesel-engine-exhaust-emissions
#13
Mohamad El Zoghbi, Pascale Salameh, Isabelle Stücker, Patrick Brochard, Fleur Delva, Aude Lacourt
BACKGROUND: Tobacco smoking is the main cause of lung cancer, but it is not the sole causal factor. Significant proportions of workers are smokers and exposed to occupational lung carcinogens. This study aims to systematically review the statistical interaction between occupational lung carcinogens and tobacco smoking, in particular asbestos, crystalline silica and diesel engine exhaust emissions. METHODS: Articles were identified using Scopus, PubMed, and Web of Science, and were limited to those published in English or French, without limitation of time...
February 2, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28129777/diesel-exhaust-alters-the-response-of-cultured-primary-bronchial-epithelial-cells-from-patients-with-chronic-obstructive-pulmonary-disease-copd-to-non-typeable-haemophilus-influenzae
#14
Maria C Zarcone, Annemarie van Schadewijk, Evert Duistermaat, Pieter S Hiemstra, Ingeborg M Kooter
BACKGROUND: Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus influenzae (NTHi), and exposures to diesel engine emissions are known to contribute to exacerbations in COPD patients. However, the effect of diesel exhaust (DE) exposure on the epithelial response to microbial stimulation is incompletely understood, and possible differences in the response to DE of epithelial cells from COPD patients and controls have not been studied...
January 28, 2017: Respiratory Research
https://www.readbyqxmd.com/read/28124139/biomarkers-of-endothelial-activation-and-thrombosis-in-tunnel-construction-workers-exposed-to-airborne-contaminants
#15
Dag G Ellingsen, Ingebjørg Seljeflot, Yngvar Thomassen, Magny Thomassen, Berit Bakke, Bente Ulvestad
OBJECTIVES: The aims were to study biomarkers of systemic inflammation, platelet/endothelial activation and thrombosis in tunnel construction workers (TCW). METHODS: Biomarkers and blood fatty acids were measured in blood of 90 TCW and 50 referents before (baseline) and towards the end (follow-up) of a 12 days work period. They had been absent from work for 9 days at baseline. Air samples were collected by personal sampling. RESULTS: Personal thoracic air samples showed geometric mean (GM) particulate matter and α-quartz concentrations of 604 and 74 µg/m(3), respectively...
January 25, 2017: International Archives of Occupational and Environmental Health
https://www.readbyqxmd.com/read/28112928/transformation-of-cerium-oxide-nanoparticles-from-a-diesel-fuel-additive-during-combustion-in-a-diesel-engine
#16
James G Dale, Steven S Cox, Marina E Vance, Linsey C Marr, Michael F Hochella
Nanoscale cerium oxide is used as a diesel fuel additive to reduce particulate matter emissions and increase fuel economy, but its fate in the environment has not been established. Cerium oxide released as a result of the combustion of diesel fuel containing the additive Envirox, which utilizes suspended nanoscale cerium oxide to reduce particulate matter emissions and increase fuel economy, was captured from the exhaust stream of a diesel engine and was characterized using a combination of bulk analytical techniques and high resolution transmission electron microscopy...
February 8, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28111596/chemical-content-and-estimated-sources-of-fine-fraction-of-particulate-matter-collected-in-krakow
#17
Lucyna Samek, Zdzislaw Stegowski, Leszek Furman, Joanna Fiedor
The monitored level of pollution remains high in Krakow, Poland. Alerts regarding increased levels of pollution, which advise asthmatics, the elderly, and children to limit their exposure to open air, continue to be issued on numerous days. In this work, seasonal variations in PM2.5 (particulate matter containing particles with aerodynamic diameter no higher than 2.5 μm) concentrations are shown. An increasing trend is reported, which is enhanced during the colder seasons. The mean PM2.5 concentrations in Krakow exceeded the target value of 25 μg/m(3) specified for 2015 in the spring, autumn, and winter seasons...
2017: Air Quality, Atmosphere, & Health
https://www.readbyqxmd.com/read/28100227/prenatal-and-postnatal-mothering-by-diesel-exhaust-pm2-5-exposed-dams-differentially-program-mouse-energy-metabolism
#18
Minjie Chen, Shuai Liang, Huifen Zhou, Yanyi Xu, Xiaobo Qin, Ziying Hu, Xiaoke Wang, Lianglin Qiu, Wanjun Wang, Yuhao Zhang, Zhekang Ying
BACKGROUND: Obesity is one of the leading threats to global public health. It is consequent to abnormal energy metabolism. Currently, it has been well established that maternal exposure to environmental stressors that cause inappropriate fetal development may have long-term adverse effects on offspring energy metabolism in an exposure timing-dependent manner, known as developmental programming of health and diseases paradigm. Rapidly increasing evidence has indicated that maternal exposure to ambient fine particles (PM2...
January 18, 2017: Particle and Fibre Toxicology
https://www.readbyqxmd.com/read/28097517/in-utero-exposure-of-hyperlipidemic-mice-to-diesel-exhaust-lack-of-effects-on-atherosclerosis-in-adult-offspring-fed-a-regular-chow-diet
#19
Jenna Harrigan, Divya Ravi, Jerry Ricks, Michael E Rosenfeld
Uterine stress is associated with an increased risk of later life metabolic diseases. In this study, we investigated the effect of diesel exhaust (DE) exposure in utero on adult susceptibility to atherosclerosis in genetically hyperlipidemic mice. Pregnant apolipoprotein E-deficient mice received either DE exposure (~250-300 μg/m(3) PM2.5 for 6 h/day, 5 days/week) or filtered air (FA) throughout gestation. Treatment effects on litter size and gender distribution were recorded. Plasma cholesterol and triglycerides were measured at 8, 12 and 16 weeks of age...
January 17, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/28071047/linking-load-fuel-and-emission-controls-to-photochemical-production-of-secondary-organic-aerosol-from-a-diesel-engine
#20
Shantanu H Jathar, Beth Friedman, Abril A Galang, Michael F Link, Patrick Brophy, John Volckens, Sailaja Eluri, Delphine K Farmer
Diesel engines are important sources of fine particle pollution in urban environments, but their contribution to the atmospheric formation of secondary organic aerosol (SOA) is not well constrained. We investigated direct emissions of primary organic aerosol (POA) and photochemical production of SOA from a diesel engine using an oxidation flow reactor (OFR). In less than a day of simulated atmospheric aging, SOA production exceeded POA emissions by an order of magnitude or more. Efficient combustion at higher engine loads coupled to the removal of SOA precursors and particle emissions by aftertreatment systems reduced POA emission factors by an order of magnitude and SOA production factors by factors of 2-10...
January 26, 2017: Environmental Science & Technology
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