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https://www.readbyqxmd.com/read/28211039/cutaneous-squamous-cell-carcinoma-an-epidemiological-review
#1
REVIEW
A C Green, C M Olsen
Cutaneous squamous cell carcinoma (SCC) is a common cancer in white populations and its disease burden is often substantially underestimated. SCC occurs more often in men than women and increases dramatically with age; those affected often develop multiple primaries over time, which increases the burden. The main external cause is solar ultraviolet radiation (UVR), with immunosuppression being the other established risk factor, shown by the high SCC rates in organ transplant recipients. Sunbed use and certain genetic disorders and medical conditions are also associated with SCC, while associations with human papillomavirus infection and high bodyweight are not established...
February 16, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28203180/metastatic-cutaneous-squamous-cell-carcinoma-with-gastrointestinal-involvement-a-case-report
#2
Brian Schwartz, Mitchell Schwartz
Metastatic squamous cell carcinoma (SCC) involving the gastrointestinal tract as the sole site of metastatic disease is exceedingly rare. We report a patient with known cutaneous SCC that metastasized to regional lymph nodes who, after therapy, appeared to be disease free until a small metastatic lesion was identified on colonoscopy within a diverticular orifice. He was subsequently noted to have more diffuse gastrointestinal involvement, including a small bowel lesion not previously identified on imaging. The presence of a gastrointestinal metastatic lesion in this setting should prompt consideration to exclude other synchronous lesions and the need for possible additional systemic therapy...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/28203172/recurrent-multiple-squamous-cell-carcinomas-on-the-scalp-in-a-patient-with-juvenile-dermatomyositis
#3
Yota Sato, Taku Fujimura, Yumi Kambayashi, Akira Tsukada, Takanori Hidaka, Kayo Tanita, Takahiro Haga, Akira Hashimoto, Setsuya Aiba
Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes...
January 2017: Case Reports in Oncology
https://www.readbyqxmd.com/read/28202188/rate-of-regional-nodal-metastases-of-cutaneous-squamous-cell-carcinoma-in-the-immunosuppressed-patient
#4
Eamon J McLaughlin, Lauren Miller, Thuzar M Shin, Joseph F Sobanko, Steven B Cannady, Christopher J Miller, Jason G Newman
PURPOSE: Immunosuppressed solid organ transplant recipients (SOTRs) have an increased risk of developing cutaneous squamous cell carcinomas (cSCCs) with metastatic potential. This study sought to determine the rate of regional lymph node involvement in a large cohort of solid organ transplant patients with cutaneous head and neck squamous cell carcinoma. MATERIALS AND METHODS: A retrospective chart review was performed on solid organ transplant patients with head and neck cutaneous squamous cell carcinoma treated at a tertiary academic medical center from 2005 to 2015...
February 4, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28199463/effect-of-methyl-aminolevulinate-photodynamic-therapy-with-and-without-ablative-fractional-laser-treatment-in-patients-with-microinvasive-squamous-cell-carcinoma-a-randomized-clinical-trial
#5
Seung-Hwan Choi, Ki-Ho Kim, Ki-Hoon Song
Importance: Surgical excision is the standard treatment for cutaneous squamous cell carcinoma (SCC). However, microinvasive SCC (Clark level II) is limited to the papillary dermis, and it should be differentiated from invasive SCC. Ablative fractional laser-primed photodynamic therapy (AFL-PDT) may have enhanced efficacy. Objective: To compare 1 session of AFL-PDT with 2 sessions of conventional methyl aminolevulinate-PDT (MAL-PDT) for the treatment of microinvasive SCC...
February 15, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28199044/prognostic-markers-in-metastatic-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#6
Nir Hirshoren, Julia Danne, Benjamin John Dixon, Matthew Magarey, Stephen Kleid, Angela Webb, Albert Tiong, June Corry, David Gyorki
BACKGROUND: The minority of head and neck cutaneous squamous cell carcinomas (SCC) metastasize to regional lymph nodes. The purpose of this study was to describe the clinical outcomes and prognostic factors for patients with node-positive head and neck cutaneous SCC who underwent lymphadenectomy. METHODS: We conducted a retrospective single center study using the Kaplan-Meier method for the investigation of the overall survival (OS) and locoregional control rates...
February 15, 2017: Head & Neck
https://www.readbyqxmd.com/read/28196178/association-of-human-papillomavirus-vaccine-with-the-development-of-keratinocyte-carcinomas
#7
Anna J Nichols, Amber Heyna Allen, Shahjahan Shareef, Evangelos V Badiavas, Robert S Kirsner, Tim Ioannides
Importance: Keratinocyte carcinomas (KCs), consisting of squamous cell carcinomas (SCCs) and basal cell carcinomas (BCCs), are the most common human malignant neoplasms. Several risk factors have been implicated in KC development. For some SCCs, particularly those in immunocompromised patients, human papillomavirus (HPV) may be an important factor. Objective: To determine whether quadrivalent HPV vaccination would affect the development of KCs in immunocompetent patients with a history of multiple KCs...
February 8, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28191672/presence-of-cutaneous-human-papillomavirus-dna-in-squamous-cell-carcinoma-of-the-scalp-a-case-series
#8
M La Placa, S Venturoli, D Barbieri, M Nocera, A Patrizi, M P Landini, P A Fanti, E Dika
Various hypotheses have been put forward on the pathogenesis of squamous cell carcinoma (SCC), including chronic sun damage and exposure to ultraviolet radiation (UVR), chemicals, smoking, immunosuppressive medications and human papillomavirus (HPV)(1) . It is well known that alpha (mucosal) HPV types, in particular HPV-16 and HPV-18, are etiologically correlated to cervical cancer and other types of anogenital carcinoma and oropharyngeal papillomatosis(1) . On the contrary, the pathogenesis of squamous cell carcinoma (SCC) outside the mucosae remains obscure, and the link with HPVs has been demonstrated only in the epidermodysplasia verruciformis context(2-3) ...
February 13, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28187958/expression-of-oncogenic-mir-17-92-and-tumor-suppressive-mir-143-145-clusters-in-basal-cell-carcinoma-and-cutaneous-squamous-cell-carcinoma
#9
Michael Sand, Schapoor Hessam, Susanne Amur, Marina Skrygan, Michael Bromba, Eggert Stockfleth, Thilo Gambichler, Falk G Bechara
BACKGROUND: A variety of cancers are associated with the expression of the oncogenic miR-17-92 cluster (Oncomir-1) and tumor suppressor miR-143-5p/miR-145-5p. Epidermal skin cancer has not been investigated for the expression of miR-17-92 and miR-143-145 clusters, despite being extensively studied regarding global microRNA profiles. The goal of this study was to investigate the expression and possible correlation of expression of miR17-92 and miR-143-145 cluster members in epidermal skin cancer...
January 31, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28186503/a-novel-dlx3-pkc-integrated-signaling-network-drives-keratinocyte-differentiation
#10
Elisabetta Palazzo, Meghan D Kellett, Christophe Cataisson, Paul W Bible, Shreya Bhattacharya, Hong-Wei Sun, Anna C Gormley, Stuart H Yuspa, Maria I Morasso
Epidermal homeostasis relies on a well-defined transcriptional control of keratinocyte proliferation and differentiation, which is critical to prevent skin diseases such as atopic dermatitis, psoriasis or cancer. We have recently shown that the homeobox transcription factor DLX3 and the tumor suppressor p53 co-regulate cell cycle-related signaling and that this mechanism is functionally involved in cutaneous squamous cell carcinoma development. Here we show that DLX3 expression and its downstream signaling depend on protein kinase C α (PKCα) activity in skin...
February 10, 2017: Cell Death and Differentiation
https://www.readbyqxmd.com/read/28185865/cutaneous-squamous-cell-cancer-cscc-risk-and-the-human-leukocyte-antigen-hla-system
#11
REVIEW
Pooja Yesantharao, Wei Wang, Nilah M Ioannidis, Shadmehr Demehri, Alice S Whitemore, Maryam M Asgari
Cutaneous squamous cell carcinoma (cSCC) is the second most common cancer among Caucasians in the United States, with rising incidence over the past decade. Treatment for non-melanoma skin cancer, including cSCC, in the United States was estimated to cost $4.8 billion in 2014. Thus, an understanding of cSCC pathogenesis could have important public health implications. Immune function impacts cSCC risk, given that cSCC incidence rates are substantially higher in patients with compromised immune systems. We report a systematic review of published associations between cSCC risk and the human leukocyte antigen (HLA) system...
February 6, 2017: Human Immunology
https://www.readbyqxmd.com/read/28181579/photoacoustic-and-fluorescence-imaging-of-cutaneous-squamous-cell-carcinoma-in-living-subjects-using-a-probe-targeting-integrin-%C3%AE-v%C3%AE-6
#12
Chao Zhang, Yong Zhang, Kai Hong, Shu Zhu, Jie Wan
Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer worldwide. Today, cSCC is diagnosed by visual inspection followed by invasive skin biopsy. There is a need to develop non-invasive diagnostic tools to achieve early and accurate detection. Photoacoustic imaging (PAI) possesses high ultrasonic resolution and strong optical contrast at new depths (<1-5 cm). Together with exogenous contrast agents, PAI has found promising use in various tumors in living subjects. The expression of integrin αvβ6 is significantly up-regulated in cSCC...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28174190/unusual-sites-of-metastases-of-carcinoma-cervix
#13
Renitha Miriam Cherian, Jenifer Jeba, Sramana Mukhopadhyay, Selvamani Backianathan
We present a case of metastatic squamous cell carcinoma cervix with solitary bone metastases to the right tibia and multiple cutaneous metastases. A woman aged 52 years with cancer of the cervix and lung metastases, after 21 months of initial diagnosis and palliative chemotherapy presented with pain in the right knee and multiple nodular skin lesions. Bone scintigraphy revealed intense increased tracer activity in the proximal and mid shaft of the right tibia. Biopsy from the tibial lesion confirmed metastatic squamous cell carcinoma...
February 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28171708/a-multi-institutional-comparison-of-outcomes-of-immunosuppressed-and-immunocompetent-patients-treated-with-surgery-and-radiation-therapy-for-cutaneous-squamous-cell-carcinoma-of-the-head-and-neck
#14
Bindu V Manyam, Adam A Garsa, Rei-I Chin, Chandana A Reddy, Brian Gastman, Wade Thorstad, Sue S Yom, Brian Nussenbaum, Steven J Wang, Allison T Vidimos, Shlomo A Koyfman
BACKGROUND: Patients who are chronically immunosuppressed have higher rates of cutaneous squamous cell carcinoma of the head and neck (cSCC-HN). This is the largest multi-institutional study to date investigating the effect of immune status on disease outcomes in patients with cSCC-HN who underwent surgery and received postoperative radiation therapy (RT). METHODS: Patients from 3 institutions who underwent surgery and also received postoperative RT for primary or recurrent, stage I through IV cSCC-HN between 1995 and 2015 were included in this institutional review board-approved study...
February 7, 2017: Cancer
https://www.readbyqxmd.com/read/28165568/microrna15b-regulates-apoptosis-of-cutaneous-squamous-cell-carcinoma-scl-1-cell-line-a-mechanism-study
#15
S-H Zhang, Z-Y Li, Z-J Liu, G-Y Miao, B-G Liu
OBJECTIVE: Cutaneous squamous cell carcinoma is a malignant tumor, which is mostly common in skin epidermis or appendages. microRNA has been proved to regulate growth and survival of cells. Our study was focused on the effect of microRNA15b on cell viability and apoptosis of cutaneous squamous cell carcinoma SCL-1 cell line. MATERIALS AND METHODS: MicroRNA15b and control microRNA were synthesized and transfected into SCL-1 cells, respectively. Effects of transfection on SCL-1 cells were evaluated by MTT assays and flow cytometry...
January 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28163451/overview-of-local-flaps-of-the-face-for-reconstruction-of-cutaneous-malignancies-single-institutional-experience-of-seventy-cases
#16
Jagdeep K Rao, Kaustubh Sharad Shende
CONTEXT: The most common malignant tumours of the face are basal cell carcinoma, squamous cell carcinoma and melanoma. While the results of skin graft are less than satisfactory for large areas to cover, distant flaps are bulky with a poor colour match. Local fasciocutaneous flaps provide reasonable option for reconstruction of facial defects with good colour and texture match and good success rate. AIMS: This study aimed to analyse the various modalities of reconstruction after resection of facial malignancies and their advantages and disadvantages...
October 2016: Journal of Cutaneous and Aesthetic Surgery
https://www.readbyqxmd.com/read/28162854/malignancy-rates-in-a-large-cohort-of-patients-with-systemically-treated-psoriasis-in-a-managed-care-population
#17
Maryam M Asgari, G Thomas Ray, Jamie L Geier, Charles P Quesenberry
BACKGROUND: Moderate to severe psoriasis often requires treatment with systemic agents, many of which have immunosuppressive properties and could increase cancer risk, including nonmelanoma skin cancer (NMSC). OBJECTIVE: We sought to estimate the overall malignancy rate (excluding NMSC) and NMSC rate among 5889 patients with systemically treated psoriasis. METHODS: We identified a cohort of adult Kaiser Permanente Northern California health plan members with psoriasis diagnosed from 1998 to 2011 and treated with at least 1 systemic antipsoriatic agent and categorized them into ever-biologic or nonbiologic users...
February 2, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28157733/squamous-cell-carcinoma-of-the-lip-a-review-of-squamous-cell-carcinogenesis-of-the-mucosal-and-cutaneous-junction
#18
James P Bota, Alexis B Lyons, Bryan T Carroll
BACKGROUND: The lip is an anatomic junction for 2 disparate groups of cancer. Cutaneous squamous cell carcinoma (cSCC) is a common malignancy with a favorable prognosis, whereas oral-mucosal squamous cell carcinoma (omSCC) is associated with significantly higher rates of nodal disease and worse outcomes. The squamous cell carcinoma of the lip (lip SCC) is more aggressive than cSCC but less aggressive than omSCC. However, work-up and treatment vary between specialties. OBJECTIVES: The authors sought to review and compare the risk factors and clinical behavior of cSCC, omSCC, and lip SCC, review tumor biology of squamous cell carcinoma, and compare work-up and treatment algorithms for lip SCC...
February 1, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28151757/drug-therapy-of-advanced-cutaneous-squamous-cell-carcinoma-is-there-any-evidence
#19
Simone Ribero, Luigia Stefania Stucci, Gregory A Daniels, Luca Borradori
PURPOSE OF REVIEW: There are few randomized controlled studies to guide the treatment of advanced cutaneous squamous cell carcinoma. The existing treatments are mostly based on case reports and small case series. Here we review recently available insights concerning the treatment of locally advanced and metastatic squamous cell carcinoma, with a special emphasis on novel targeted therapy and immunotherapy. RECENT FINDINGS: Surgery and combination of chemotherapy and radiation therapy have been long considered the gold standard options for advanced squamous cell carcinoma...
March 2017: Current Opinion in Oncology
https://www.readbyqxmd.com/read/28149222/merkel-cell-carcinoma-of-the-hand-a-case-report-and-review-of-the-literature
#20
Donevan R Westerveld, David J Hall, Winston T Richards
Background: Merkel cell carcinoma (MCC) is a relatively rare and aggressive cutaneous neuroendocrine malignancy characterized by high incidence of local recurrence, distant metastases, regional nodal metastases, and high mortality. Clinically, MCC presents as a persistent asymptomatic red/pink shaped nodule, usually smaller than 2 cm with nontender intracutaneous swelling, with rapidly growing localized disease with lymph node metastases preceding distant metastases. Because of its rare nature and the lack of comprehensive understanding of the disease, management of MCC has been controversial...
December 2016: Hand: Official Journal of the American Association for Hand Surgery
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