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https://www.readbyqxmd.com/read/29679277/the-role-of-mitochondrial-dna-damage-at-skeletal-muscle-oxidative-stress-on-the-development-of-type-2-diabetes
#1
Julia Matzenbacher Dos Santos, Denise Silva de Oliveira, Marcos Lazaro Moreli, Sandra Aparecida Benite-Ribeiro
Reduced cellular response to insulin in skeletal muscle is one of the major components of the development of type 2 diabetes (T2D). Mitochondrial dysfunction involves in the accumulation of toxic reactive oxygen species (ROS) that leads to insulin resistance. The aim of this study was to verify the involvement of mitochondrial DNA damage at ROS generation in skeletal muscle during development of T2D. Wistar rats were fed a diet containing 60% fat over 8 weeks and at day 14 a single injection of STZ (25 mg/kg) was administered (T2D-induced)...
April 20, 2018: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/29679223/association-between-lepr-fto-mc4r-and-pparg-2-polymorphisms-with-obesity-traits-and-metabolic-phenotypes-in-school-aged-children
#2
Sílvia M Almeida, José M Furtado, Paulo Mascarenhas, Maria E Ferraz, José C Ferreira, Mariana P Monteiro, Manuel Vilanova, Fernando P Ferraz
PURPOSE: Evaluate the relationship of leptin receptor (LEPR) rs1137101, fat mass obesity-associated (FTO) receptors 9939609, melanocortin-4 receptors (MC4R) rs2229616 and rs17782313, and proliferator-activated receptor-gamma (PPARG) rs1801282 with clinical and metabolic phenotypes in prepubertal children. RESEARCH QUESTION: What is the effect of polymorphisms on clinical and metabolic phenotypes in prepubertal children? METHODS: A cross-sectional descriptive study was performed to evaluate anthropometric features, percentage body fat (%BF), biochemical parameters, and genotype in 773 prepubertal children...
April 20, 2018: Endocrine
https://www.readbyqxmd.com/read/29678978/community-based-diagnosis-of-non-communicable-diseases-and-their-risk-factors-in-rural-and-urban-haiti-a-cross-sectional-prevalence-study
#3
Vincent DeGennaro, Stuart Malcolm, Lindsay Crompton, Krishna Vaddiparti, Lazarus K Mramba, Catherine Striley, Linda Cottler, Kellee Taylor, Robert Leverence
OBJECTIVE: To estimate the prevalence of hypertension, diabetes and chronic kidney disease and their risk factors in a rural and urban region of Haiti. SETTING AND PARTICIPANTS: Community health workers enumerated 2648 households (909 rural and 1739 urban) via a multistage cluster random sampling method from July 2015 to May 2016, completed 705 rural and 1419 urban assessments for adults aged 25-65 years. OUTCOME MEASURES: We performed a WHO STEPS based questionnaire, measured two blood pressure values, weight, height, abdominal circumference and point of care test finger stick blood sample for haemoglobin A1c, creatinine and cholesterol (total, high density lipoprotein (HDL) and triglycerides)...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678641/liver-directed-microrna-7a-depletion-induces-nonalcoholic-fatty-liver-disease-by-stabilizing-yy1-mediated-lipogenic-pathways-in-zebrafish
#4
Chi-Yu Lai, Chiu-Ya Lin, Chia-Chun Hsu, Kun-Yun Yeh, Guor Mour Her
Nonalcoholic fatty liver disease (NAFLD) has been associated with the function and changes in expression levels of microRNAs (miRs). MiR-7 has been proven to play an important role in many cellular processes; however, its functions in the context of liver lipogenesis remain unknown. We applied the microRNA-sponge (miR-SP) technology and generated transgenic miR-7a-SP models (hC7aSP and bC7aSP), which disrupted the activities of hepatic miR-7a and induced the early onset of NAFLD and nonalcoholic steatohepatitis (NASH) in zebrafish...
April 17, 2018: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29678637/is-the-occlusion-site-of-the-lenticulostriate-artery-identified-on-admission-related-to-clinical-prognosis-in-patients-with-lacunar-stroke
#5
Masaki Naganuma, Yuichiro Inatomi, Makoto Nakajima, Takeshi Ohta, Toshiro Yonehara, Yukio Ando
BACKGROUND: The mechanism of lacunar stroke (LS) is rather speculative due to the lack of neuropathological evidence in clinical practice. To explore the significance of the occlusion site of the lenticulostriate artery (LSA) to this mechanism, we investigated the characteristics and prognosis of patients with LS with proximal occlusions. MATERIALS AND METHODS: We studied 202 patients with acute LS in the region of the LSA. The presumed occlusion site of the LSA was assessed on coronal, diffusion-weighted magnetic resonance images...
April 17, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29678607/association-between-hypertension-and-metabolic-disorders-among-elderly-patients-in-north-jordan
#6
Nuha Alwardat, Laura Di Renzo, Renata Costa de Miranda, Sofian Alwardat, Paola Sinibaldi Salimei, Antonino De Lorenzo
BACKGROUND: Hypertension (HTN), dyslipidemia and hyperglycemia are major risk factors for cardiovascular disease, accounting for the highest morbidity and mortality among the elderly Jordanian population. This study aimed to evaluate serum lipid and glucose profiles of hypertensive patients and normotensive controls, and determine the risk factors for HTN among elderly population in Jordan. METHODS: A cross-sectional study was carried out among 200 participants, including 111 hypertensive patients and 89 normotensive controls from June to October 2017 in North Jordan...
April 12, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678606/ketogenic-diet-high-intensity-interval-training-hiit-and-memory-training-in-the-treatment-of-mild-cognitive-impairment-a-case-study
#7
Kaitlyn Dahlgren, Kelly J Gibas
Alzheimer's disease (AD) deaths have increased by 89% since 2000. This alarming trajectory of neurological disease highlights the failure of current best practice. Deteriorating brain fuel supply is the nemesis of intact neurological health. Cerebral hypo-metabolism associated with AD occurs years before onset. Both the ketogenic diet and calorie restriction (fasting) lead to a compensatory rise in ketones to improve energy deficits in the brain derived from cerebral insulin resistance. Two forms of ketone bodies, β-hydroxybutyrate and acetoacetate, fuel the brain during starvation, fasting and strenuous exercise...
April 11, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29678570/overexpression-of-nrk1-ameliorates-diet-and-age-induced-hepatic-steatosis-and-insulin-resistance
#8
Rui Fan, Jing Cui, Feng Ren, Qingzhi Wang, Yanmei Huang, Bin Zhao, Lai Wei, Xinlai Qian, Xiwen Xiong
NAD+ is a co-enzyme in redox reactions and a substrate required for activity of various enzyme families, including Sirtuins and poly(ADP-ribose) polymerases. Dietary supplementation of NAD+ precursors nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR) protects against metabolic disease, neurodegenerative disorders and age-related physiological decline in mammals. Here we sought to identify the roles of nicotinamide riboside kinase 1 (NRK1) plays in regulating hepatic NAD+ biosynthesis and lipid metabolism...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29678421/growth-hormone-receptor-deficient-pigs-resemble-the-pathophysiology-of-human-laron-syndrome-and-reveal-altered-activation-of-signaling-cascades-in-the-liver
#9
Arne Hinrichs, Barbara Kessler, Mayuko Kurome, Andreas Blutke, Elisabeth Kemter, Maren Bernau, Armin M Scholz, Birgit Rathkolb, Simone Renner, Sebastian Bultmann, Heinrich Leonhardt, Martin Hrabĕ de Angelis, Hiroshi Nagashima, Andreas Hoeflich, Werner F Blum, Martin Bidlingmaier, Rüdiger Wanke, Maik Dahlhoff, Eckhard Wolf
OBJECTIVE: Laron syndrome (LS) is a rare, autosomal recessive disorder in humans caused by loss-of-function mutations of the growth hormone receptor (GHR) gene. To establish a large animal model for LS, pigs with GHR knockout (KO) mutations were generated and characterized. METHODS: CRISPR/Cas9 technology was applied to mutate exon 3 of the GHR gene in porcine zygotes. Two heterozygous founder sows with a 1-bp or 7-bp insertion in GHR exon 3 were obtained, and their heterozygous F1 offspring were intercrossed to produce GHR-KO, heterozygous GHR mutant, and wild-type pigs...
March 15, 2018: Molecular Metabolism
https://www.readbyqxmd.com/read/29678178/status-of-lipid-and-lipoprotein-in-female-breast-cancer-patients-at-initial-diagnosis-and-during-chemotherapy
#10
Xin Li, Zi-Li Liu, Yu-Tuan Wu, He Wu, Wei Dai, Bilal Arshad, Zhou Xu, Hao Li, Kai-Nan Wu, Ling-Quan Kong
BACKGROUND: The lipid profile status among breast cancer patients at initial diagnosis and during chemotherapy remain controversial. The aim of this study is to study the status of lipid and lipoprotein in female breast cancer patients at initial diagnosis and during chemotherapy. METHODS: We conducted a retrospective cohort study of the status of the lipid and lipoprotein in 1054 primarily diagnosed breast cancer patients and 2483 normal controls with age stratification, from July 2015 to October 2016...
April 20, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29677628/circulating-metabolomic-profile-can-predict-dyslipidemia-in-hiv-patients-undergoing-antiretroviral-therapy
#11
Esther Rodríguez-Gallego, Josep Gómez, Pere Domingo, Sara Ferrando-Martínez, Joaquim Peraire, Consuelo Viladés, Sergi Veloso, Miguel López-Dupla, Raúl Beltrán-Debón, Verónica Alba, Montserrat Vargas, Alfonso J Castellano, Manuel Leal, Yolanda María Pacheco, Ezequiel Ruiz-Mateos, Félix Gutiérrez, Francesc Vidal, Anna Rull
BACKGROUND AND AIMS: Dyslipidemia in HIV-infected patients is unique and pathophysiologically associated with host factors, HIV itself and the use of antiretroviral therapy (ART). The use of nuclear magnetic resonance spectroscopy (NMR) provides additional data to conventional lipid measurements concerning the number of lipoprotein subclasses and particle sizes. METHODS: To investigate the ability of lipoprotein profile, we used a circulating metabolomic approach in a cohort of 103 ART-naive HIV-infected patients, who were initiating non-nucleoside analogue transcriptase inhibitor (NNRTI)-based ART, and we subsequently followed up these patients for 36 months...
April 9, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29677459/hepatoprotective-and-antioxidant-properties-of-the-aqueous-extract-of-olea-europaea-leaves-against-diclofenac-induced-liver-damages-in-mice
#12
Rawya Soussi, Najla Hfaiedh, Fatma Guesmi, Mohsen Sakly, Khémais Ben Rhouma
Historically, olive tree "Olea europaea" is one of the most important fruit trees in Mediterranean countries. Several studies suggest that olive leaf is a significant source of bioactive phenolic compounds compared to olive oil and fruits. This study was undertaken to investigate, the protective effect of the aqueous extract of « Chemlali » olive leaves against diclofenac-induced damages in liver and haematological alterations in swiss albinos mice. For this, twenty-eight mice were divided into four groups: a control group, a diclofenac-treated group (2...
April 20, 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
https://www.readbyqxmd.com/read/29677106/effect-of-propofol-continuous-rate-infusion-on-intravenous-glucose-tolerance-test-in-dogs
#13
Kenichi Maeda, Munehiro Iwasaki, Yuki Itou, Satomi Iwai, Shozo Okano
Hyperglycemia causes perioperative complications and many anesthetics impair glucose metabolism and cause hyperglycemia. We evaluated the effects of propofol on blood glucose metabolism and insulin secretion during an intravenous glucose tolerance test (IVGTT) in dogs. Blood glucose, insulin, triglyceride, cholesterol, and free fatty acid (FFA) levels were measured in dogs during IVGTT in a conscious state and under the effect of 2.0% isoflurane, low-concentration propofol (0.2 mg/kg/min), and high-concentration propofol (0...
April 20, 2018: Veterinary Sciences
https://www.readbyqxmd.com/read/29677099/optimal-adherence-to-a-mediterranean-diet-and-high-muscular-fitness-are-associated-with-a-healthier-cardiometabolic-profile-in-collegiate-students
#14
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Mónica Liliana Ojeda-Pardo, Carolina Sandoval-Cuellar, Antonio García-Hermoso, Hugo Alejandro Carrillo, Katherine González-Ruíz, Daniel Humberto Prieto-Benavides, Alejandra Tordecilla-Sanders, Arvydas Martinkėnas, César Agostinis-Sobrinho
The aim of the study was to investigate the combined association of adherence to a Mediterranean diet (MedDiet) and muscular fitness (MF) with cardiometabolic health in collegiate students. The present cross-sectional analysis consisted of 1248 (714 females) healthy collegiate students (20.1 ± 2.7 years old). Adherence to a MedDiet was assessed by a KIDMED (Mediterranean Diet Quality Index) questionnaire. Standing broad jump, standing vertical jump, and isometric handgrip dynamometry were used as indicators of MF...
April 20, 2018: Nutrients
https://www.readbyqxmd.com/read/29676936/pediatric-metabolic-outcome-comparisons-based-on-a-spectrum-of-obesity-and-asthmatic-symptoms
#15
Ashley D Perdue, Lesley A Cottrell, Christa L Lilly, William A Gower, Brian A Ely, Brad Foringer, Melvin L Wright, William A Neal
RATIONALE: Asthma and obesity are two of the most prevalent public health issues for children in the U.S. Trajectories of both have roughly paralleled one another over the past several decades causing many to explore their connection to one another and to other associated health issues such as diabetes and dyslipidemia. Earlier models have commonly designated obesity as the central hub of these associations; however, more recent models have argued connections between pediatric asthma and other obesity-related metabolic conditions regardless of children's obesity risk...
April 20, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29676049/moderate-weight-loss-improves-body-composition-and-metabolic-function-in-metabolically-unhealthy-lean-subjects
#16
Yu Chung Chooi, Cherlyn Ding, Zhiling Chan, John Choo, Suresh Anand Sadananthan, Navin Michael, Yijun Lee, S Sendhil Velan, Faidon Magkos
OBJECTIVE: Individuals who have "metabolically obese normal weight" (MONW) have an increased risk for cardiometabolic disease. Moderate weight loss has multiple benefits in people with obesity, but its effects in lean people are unknown. Thus, the effects of diet-induced 5% weight loss on body composition and metabolic function in MONW subjects were evaluated. METHODS: Total body fat, visceral adipose tissue (VAT) and subcutaneous abdominal adipose tissue (SAT) volumes, intrahepatic and intramyocellular lipid contents, insulin sensitivity (hyperinsulinemic-euglycemic clamp), glucose tolerance, and postprandial insulin secretion and clearance rates (mixed meal with minimal modeling) were measured before and after 4...
April 19, 2018: Obesity
https://www.readbyqxmd.com/read/29675735/xanthogranulomatosis-of-the-spleen-a-case-report
#17
Goshi Fujimoto, Ken Hayashi, Shigetoshi Yamada, Hiroshi Kusanagi, Koichi Honma
BACKGROUND: Xanthogranulomatous inflammation is recognized as a subtype of cholecystitis; however, it can also occur in other organs. Xanthogranulomatosis of the kidney, bone, ovary, endometrium, vagina, prostate, lymph nodes and pancreas was reported. Herein, we report a case of laparoscopic splenectomy in a patient with xanthogranulomatosis of the spleen that was difficult to diagnose preoperatively. CASE PRESENTATION: A 63-year-old man with a past medical history of hyperlipidemia had gradually growing multiple splenic masses, which were revealed on abdominal ultrasonography...
April 19, 2018: Surgical Case Reports
https://www.readbyqxmd.com/read/29675435/serum-levels-of-interleukin-13-increase-in-subjects-with-insulin-resistance-but-do-not-correlate-with-markers-of-low-grade-systemic-inflammation
#18
Camilo P Martínez-Reyes, Angélica Y Gómez-Arauz, Israel Torres-Castro, Aarón N Manjarrez-Reyna, León F Palomera, Alfonso Olivos-García, Edith Mendoza-Tenorio, Gabriela A Sánchez-Medina, Sergio Islas-Andrade, Guillermo Melendez-Mier, Galileo Escobedo
Experimental evidence in mice suggests a role for interleukin- (IL-) 13 in insulin resistance and low-grade systemic inflammation. However, IL-13 serum levels have not been assessed in subjects with insulin resistance, and associations of IL-13 with parameters of low-grade systemic inflammation are still unknown. Our main goal was to examine the systemic levels of IL-13 in patients with insulin resistance, while also studying the relationship of IL-13 with anthropometric, metabolic, and low-grade systemic inflammatory markers...
2018: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29675053/the-potential-effect-of-chinese-herbal-formula-hongqijiangzhi-fang-in-improving-nafld-focusing-on-nlrp3-inflammasome-and-gut-microbiota
#19
Shu Liang, Yupei Zhang, Yuanjun Deng, Yifang He, Yinji Liang, Zien Liang, Yanning Chen, Kairui Tang, Runsen Chen, Qinhe Yang
The present study investigates the potential therapeutic mechanism underlying the effects of the Chinese herbal formula Hongqijiangzhi Fang (HJF) on nonalcoholic fatty liver disease (NAFLD) in rats. Male Sprague Dawley (SD) rats were randomly divided into 4 groups ( n = 8): control group was fed a normal diet, three other groups were fed high-fat diets (HFD), and the two treatment groups were intragastrically given a compound probiotic or HJF during the molding time. After 16 w, related indices were detected...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29674361/is-decreased-lung-function-associated-with-chronic-kidney-disease-a-retrospective-cohort-study-in-korea
#20
Soo Kyoung Kim, Ji Cheol Bae, Jong-Ha Baek, Kyu Yeon Hur, Moon-Kyu Lee, Jae Hyeon Kim
OBJECTIVE: There is some evidence that lung function and chronic kidney disease (CKD) may be related. We evaluated the impact of lung function on the development of CKD in a large-scale longitudinal study. METHOD: Retrospective longitudinal analyses were conducted among subjects who participated in comprehensive health check-ups at least four times during 7 years (between 2006 and 2012). We investigated the development of CKD during the follow-up period according to lung function status...
April 19, 2018: BMJ Open
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