keyword
MENU ▼
Read by QxMD icon Read
search

triglycerides

keyword
https://www.readbyqxmd.com/read/28231304/a-four-day-western-style-dietary-intervention-causes-reductions-in-hippocampal-dependent-learning-and-memory-and-interoceptive-sensitivity
#1
Tuki Attuquayefio, Richard J Stevenson, Megan J Oaten, Heather M Francis
In animals, a Western style diet-high in saturated fat and added sugar-causes impairments in hippocampal-dependent learning and memory (HDLM) and perception of internal bodily state (interoception). In humans, while there is correlational support for a link between Western-style diet, HDLM, and interoception, there is as yet no causal data. Here, healthy individuals were randomly assigned to consume either a breakfast high in saturated fat and added sugar (Experimental condition) or a healthier breakfast (Control condition), over four consecutive days...
2017: PloS One
https://www.readbyqxmd.com/read/28231052/review-the-role-of-peroxisome-proliferator-activated-receptor-in-the-treatment-of-non-alcoholic-fatty-liver-disease
#2
Xin Sun, Yan Zhang, Meilin Xie
Non-alcoholic fatty liver disease (NAFLD) has been defined as a spectrum of histological abnormalities and is characterized by significant and excessive accumulation of triglycerides in the hepatocytes in patients without alcohol consumption or other diseases. Current studies are targeting new molecular mechanisms that underlie NAFLD and associated metabolic disorders. Many therapeutic targets have been found and used in clinical studies. Peroxisome proliferator-activated receptors (PPARs) are among the potential targets and have been demonstrated to exert a pivotal role in modulation of NAFLD...
March 1, 2017: Acta Pharmaceutica
https://www.readbyqxmd.com/read/28230784/the-effects-of-moderate-whole-grain-consumption-on-fasting-glucose-and-lipids-gastrointestinal-symptoms-and-microbiota
#3
Danielle N Cooper, Mary E Kable, Maria L Marco, Angela De Leon, Bret Rust, Julita E Baker, William Horn, Dustin Burnett, Nancy L Keim
This study was designed to determine if providing wheat, corn, and rice as whole (WG) or refined grains (RG) under free-living conditions will change parameters of health over a six-week intervention in healthy, habitual non-WG consumers. Measurements of body composition, fecal microbiota, fasting blood glucose, total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), and triglycerides were made at baseline and post intervention. Subjects were given adequate servings of either WG or RG products based on their caloric need and asked to keep records of grain consumption, bowel movements, and GI symptoms weekly...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28230607/effects-of-probiotics-on-nonalcoholic-fatty-liver-disease-in-obese-children-and-adolescents
#4
Fatemeh Famouri, Zainab Shariat, Mahin Hashemipour, Mojtaba Keikha, Roya Kelishadi
OBJECTIVES: This study aims to evaluate the effects of some probiotics on sonographic and biochemical nonalcoholic fatty liver disease (NAFLD). METHODS: This randomized triple-blind trial was conducted among 64 obese children with sonographic NAFLD. They were randomly allocated to receive probiotic capsule (containing Lactobacillus acidophilus ATCC B3208, 3 × 10 colony forming units [CFU]; Bifidobacterium lactis DSMZ 32269, 6 × 10 CFU; Bifidobacterium bifidum ATCC SD6576, 2 × 10 CFU; Lactobacillus rhamnosus DSMZ 21690, 2 × 10 CFU) or placebo for 12 weeks...
March 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28230201/relapsing-remitting-multiple-sclerosis-patients-display-an-altered-lipoprotein-profile-with-dysfunctional-hdl
#5
Winde Jorissen, Elien Wouters, Jeroen F Bogie, Tim Vanmierlo, Jean-Paul Noben, Denis Sviridov, Niels Hellings, Veerle Somers, Roland Valcke, Bart Vanwijmeersch, Piet Stinissen, Monique T Mulder, Alan T Remaley, Jerome J A Hendriks
Lipoproteins modulate innate and adaptive immune responses. In the chronic inflammatory disease multiple sclerosis (MS), reports on lipoprotein level alterations are inconsistent and it is unclear whether lipoprotein function is affected. Using nuclear magnetic resonance (NMR) spectroscopy, we analysed the lipoprotein profile of relapsing-remitting (RR) MS patients, progressive MS patients and healthy controls (HC). We observed smaller LDL in RRMS patients compared to healthy controls and to progressive MS patients...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28230173/a-novel-physiological-role-for-cardiac-myoglobin-in-lipid-metabolism
#6
Ulrike B Hendgen-Cotta, Sonja Esfeld, Cristina Coman, Robert Ahrends, Ludger Klein-Hitpass, Ulrich Flögel, Tienush Rassaf, Matthias Totzeck
Continuous contractile activity of the heart is essential and the required energy is mostly provided by fatty acid (FA) oxidation. Myocardial lipid accumulation can lead to pathological responses, however the underlying mechanisms remain elusive. The role of myoglobin in dioxygen binding in cardiomyocytes and oxidative skeletal muscle has widely been appreciated. Our recent work established myoglobin as a protector of cardiac function in hypoxia and disease states. We here unravel a novel role of cardiac myoglobin in governing FA metabolism to ensure the physiological energy production through β-oxidation, preventing myocardial lipid accumulation and preserving cardiac functions...
February 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28229628/impaired-glucose-tolerance-after-streptozotocin-microinjection-into-the-mediodorsal-prefrontal-cortex-of-the-rat
#7
B Nagy, I Szabó, G Takács, B Csetényi, E Hormay, Z Karádi
The mediodorsal prefrontal cortex (mdPFC) is a key structure of the central glucose-monitoring (GM) neural network. Previous studies indicate that intracerebral streptozotocin (STZ) microinjection-induced destruction of local chemosensory neurons results in feeding and metabolic alterations. The present experiments aimed to examine whether STZ microinjection into the mdPFC causes metabolic deficits. To do so, glucose tolerance test (GTT) and measurements of plasma metabolites were performed in STZ-treated or control rats...
December 2016: Physiol Int
https://www.readbyqxmd.com/read/28229547/the-association-between-cytomegalovirus-infection-obesity-and-metabolic-syndrome-in-u-s-adult-females
#8
Shannon Fleck-Derderian, William McClellan, Janet M Wojcicki
OBJECTIVE: The purpose of this analysis was to determine whether cytomegalovirus (CMV) infection is associated with the prevalence of metabolic syndrome (MetS) and whether this relationship differs by BMI. METHODS: Data from the 1999-2004 National Health and Nutrition Examination Survey (NHANES) were pooled (N = 2,532). Logistic regression was used for assessing the association between CMV and MetS, stratified by gender and BMI, categorized as normal weight, overweight, obesity, and extreme obesity, and adjusted for age, race/ethnicity, and poverty level...
March 2017: Obesity
https://www.readbyqxmd.com/read/28229388/effects-of-boron-supplementation-on-peripartum-dairy-cows-health
#9
Abdullah Basoglu, Nuri Baspinar, Leonardo Tenori, Alessia Vignoli, Erdem Gulersoy
Although many different dietary studies on the prevention of negative energy balance related diseases are often encountered, this is the first study investigating the effects of boron supplementation on peripartum dairy cows' health in the light of an omics approach. Twenty-eight healthy cows (1 control and 3 experimental groups) were enrolled from 2 months before predicted calving until 2 months after calving. Experimental groups were assigned to receive boron at increasing doses as an oral bolus. Production parameters, biochemical profile, Nuclear Magnetic Resonance based metabolomics profile, and mRNA abundance of gluconeogenic enzymes and lipid oxidation genes were determined...
February 22, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28229243/correlation-of-insulin-resistance-and-motor-function-in-spinal-and-bulbar-muscular-atrophy
#10
Hideaki Nakatsuji, Amane Araki, Atsushi Hashizume, Yasuhiro Hijikata, Shinichiro Yamada, Tomonori Inagaki, Keisuke Suzuki, Haruhiko Banno, Noriaki Suga, Yohei Okada, Manabu Ohyama, Tohru Nakagawa, Ken Kishida, Tohru Funahashi, Iichiro Shimomura, Hideyuki Okano, Masahisa Katsuno, Gen Sobue
This study aimed to evaluate various metabolic parameters in patients with spinal and bulbar muscular atrophy (SBMA), to investigate the association between those indices and disease severity, and to explore the underlying molecular pathogenesis. We compared the degree of obesity, metabolic parameters, and blood pressure in 55 genetically confirmed SBMA patients against those in 483 age- and sex-matched healthy control. In SBMA patients, we investigated the correlation between these factors and motor functional indices...
February 22, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28228847/c-peptide-is-independent-associated-with-diabetic-peripheral-neuropathy-a-community-based-study
#11
Xiaona Qiao, Hangping Zheng, Shuo Zhang, Siying Liu, Qian Xiong, Fei Mao, Zhaoyun Zhang, Jie Wen, Hongying Ye, Yiming Li, Bin Lu
BACKGROUND: Because the relationship between C-peptide and diabetic peripheral neuropathy (DPN) is controversial, the aim of our study was to evaluate the relationship between C-peptide and DPN in community-based Chinese patients with type 2 diabetes. METHODS: In total, 220 consecutive type 2 diabetic patients treated by our regional medical consortium were enrolled. DPN was assessed by clinical symptoms, signs, and electromyography. RESULTS: Fasting C-peptide, 2-h postprandial C-peptide and ΔC-peptide (i...
2017: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/28228702/catechin-treatment-ameliorates-diabetes-and-its-complications-in-streptozotocin-induced-diabetic-rats
#12
Saeed Samarghandian, Mohsen Azimi-Nezhad, Tahereh Farkhondeh
CONTEXT: Diabetes mellitus causes atherosclerosis and lipid abnormalities. Hypolipidemic and antioxidative properties of catechin (CTN) have been reported in several studies. OBJECTIVE: This study assesses the possible protective effects of CTN against oxidative damage in the diabetic rats. MATERIALS AND METHODS: The rats were divided into the control, untreated diabetic, and 3 CTN-treated diabetic groups (20, 40, and 80 mg/kg/d, intraperitoneal)...
January 2017: Dose-response: a Publication of International Hormesis Society
https://www.readbyqxmd.com/read/28228421/randomized-clinical-trial-in-vitamin-d-deficient-adults-comparing-replenishment-with-oral-vitamin-d3-with-narrow-band-uv-type-b-light-effects-on-cholesterol-and-the-transcriptional-profiles-of-skin-and-blood
#13
Manish P Ponda, Yupu Liang, Jaehwan Kim, Richard Hutt, Kathleen Dowd, Patricia Gilleaudeau, Mary M Sullivan-Whalen, Tori Rodrick, Dong Joo Kim, Irina Barash, Michelle A Lowes, Jan L Breslow
Background: Vitamin D deficiency, defined as a serum 25-hydroxyvitamin D [25(OH)D] concentration <20 ng/mL, is correlated with a more atherogenic lipid profile. However, oral vitamin D supplementation does not lower LDL-cholesterol concentrations or raise HDL-cholesterol concentrations. This uncoupling between association and causation may result from a failure of oral vitamin D to mimic the effect of dermally synthesized vitamin D in response to ultraviolet type B (UVB) light.Objective: We tested the hypothesis that, in vitamin D-deficient adults, the replenishment of vitamin D with UVB exposure would lower LDL-cholesterol concentrations compared with the effect of oral vitamin D3 supplementation...
February 22, 2017: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28228318/endocrine-and-cardiometabolic-cord-blood-characteristics-of-offspring-born-to-mothers-with-and-without-polycystic-ovary-syndrome
#14
Nadine M P Daan, Maria P H Koster, Regine P Steegers-Theunissen, Marinus J C Eijkemans, B C J M Fauser
OBJECTIVE: To compare the endocrine and cardiometabolic cord blood characteristics of offspring of mothers with polycystic ovary syndrome (PCOS) with those of healthy controls. DESIGN: Cross-sectional case control study. SETTING: University medical centers. PATIENT(S): Offspring from mothers with PCOS (n = 61) and healthy controls (n = 82). INTERVENTION(S): Cord blood withdrawal from neonates. MAIN OUTCOME MEASURE(S): Cord blood estradiol, androstenedione, dehydroepiandrosterone sulfate (DHEAS), testosterone, sex hormone-binding globulin, free androgen index (FAI), insulin, total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, c-reactive protein, adiponectin, and leptin...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28228317/short-term-therapy-with-combination-dipeptidyl-peptidase-4-inhibitor-saxagliptin-metformin-extended-release-xr-is-superior-to-saxagliptin-or-metformin-xr-monotherapy-in-prediabetic-women-with-polycystic-ovary-syndrome-a-single-blind-randomized-pilot-study
#15
Karen E Elkind-Hirsch, Martha S Paterson, Ericka L Seidemann, Hanh C Gutowski
OBJECTIVE: To evaluate efficacy with the dipeptidyl peptidase-4 inhibitor saxagliptin (SAXA), metformin extended release (MET), and combination (SAXA-MET) in patients with polycystic ovary syndrome (PCOS) and impaired glucose regulation. DESIGN: Prospective, randomized, single-blind drug study. SETTING: Outpatient clinic. PATIENT(S): Patients (n = 38) with PCOS (aged 18-42 years) and prediabetic hyperglycemia determined by a 75-gram oral glucose tolerance test...
January 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28228309/correlation-of-compliance-to-statin-therapy-with-lipid-profile-and-serum-hmgcoa-reductase-levels-in-dyslipidemic-patients
#16
Abhinav Grover, Harmeet Singh Rehan, Lalit Kumar Gupta, Madhur Yadav
BACKGROUND: The efficacy of statin therapy may be lost or vary with reduction in compliance and intensity of statin therapy. OBJECTIVE: To study and correlate the quantitative effect of compliance on lipid profile and 3-hydroxyl-3-methylglutaryl coenzyme A reductase (HMGCoA-R) levels in dyslipidemic patients. METHODS: Compliance to different intensity of statin therapy assessed by pill count was correlated with serum levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB) and HMGCoA-R...
January 2017: Indian Heart Journal
https://www.readbyqxmd.com/read/28228098/anti-obesity-effect-of-ethanolic-extract-from-cosmos-caudatus-kunth-leaf-in-lean-rats-fed-a-high-fat-diet
#17
Hafeedza Abdul Rahman, Najla Gooda Sahib, Nazamid Saari, Faridah Abas, Amin Ismail, Muhammad Waseem Mumtaz, Azizah Abdul Hamid
BACKGROUND: Obesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL). METHODS: In this study, the rats were randomly divided into six groups i.e., (1) Normal Diet (ND); (2) Normal Diet and 175 mg/kgBW of EECCL (ND + 175 mg/kgBW); (3) Normal Diet and 350 mg/kgBW of EECCL (ND + 350 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 175 mg/kgBW of EECCL (HFD + 175 mg/kgBW); (6) High Fat Diet and 350 mg/kgBW of EECCL (HFD + 350 mg/kgBW)...
February 22, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28226200/effectiveness-of-group-based-self-management-education-for-individuals-with-type%C3%A2-2-diabetes-a-systematic-review-with-meta-analyses-and-meta-regression
#18
K Odgers-Jewell, L E Ball, J T Kelly, E A Isenring, D P Reidlinger, R Thomas
AIMS: Patient education for the management of Type 2 diabetes can be delivered in various forms, with the goal of promoting and supporting positive self-management behaviours. This systematic review aimed to determine the effectiveness of group-based interventions compared with individual interventions or usual care for improving clinical, lifestyle and psychosocial outcomes in people with Type 2 diabetes. METHODS: Six electronic databases were searched. Group-based education programmes for adults with Type 2 diabetes that measured HbA1c and followed participants for ≥ 6 months were included...
February 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28226031/evaluation-of-clinical-and-laboratory-markers-of-cardiometabolic-risk-in-overweight-and-obese-children-and-adolescents
#19
Heloísa Marcelina da Cunha Palhares, Adriana Paula da Silva, Daniela Cristina Silva Resende, Gilberto de Araújo Pereira, Virmondes Rodrigues, Maria de Fátima Borges
OBJECTIVE: This study analyzed the frequency of cardiometabolic risk markers and metabolic syndrome occurrence in overweight and obese children and adolescents. METHODS: The participants included 161 overweight (n=65) and obese (n=96) individuals aged between 5 and 19 years. Clinical markers were assessed (body mass index, body fat percentage, waist circumference, acanthosis, systolic and diastolic blood pressures, laboratory parameters [glucose, insulin, cholesterol (total and fractions) and triglyceride levels and homeostasis model assessment of insulin resistance (HOMA-IR) index] and leptin and adiponectin levels)...
January 1, 2017: Clinics
https://www.readbyqxmd.com/read/28225998/heparin-and-insulin-in-the-management-of-hypertriglyceridemia-associated-pancreatitis-case-series-and-literature-review
#20
Mohammad Shafi Kuchay, Khalid J Farooqui, Tarannum Bano, Manoj Khandelwal, Harmandeep Gill, Ambrish Mithal
Severe hypertriglyceridemia accounts for up to 7% of all cases of acute pancreatitis. Heparin and insulin activate lipoprotein lipase (LPL), thereby reducing plasma triglyceride levels. However, the safety and efficacy of heparin and insulin in the treatment of hypertriglyceridemia-associated acute pancreatitis have not been well established yet. We successfully used heparin and insulin as first-line therapy in four consecutive patients with acute pancreatitis secondary to hypertriglyceridemia. In a literature search, we revised almost all reports published to date of patients managed successfully with this combination...
February 13, 2017: Archives of Endocrinology and Metabolism
keyword
keyword
28177
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"