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https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#1
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28730477/utilizing-the-luminex-magnetic-bead-based-suspension-array-for-rapid-multiplexed-phosphoprotein-quantification
#2
Adam Stewart, Udai Banerji
The study of protein phosphorylation is critical for the advancement of our understanding of cellular responses to external and internal stimuli. Phosphorylation, the addition of phosphate groups, most often occurs on serine, threonine, or tyrosine residues due to the action of protein kinases. This structural change causes the protein to become activated (or deactivated) and enables it in turn to initiate the phosphorylation of other proteins in a cascade, eventually causing cell-wide changes such as apoptosis, cell differentiation, and growth (among others)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28727561/a-cots-based-microwave-imaging-system-for-breast-cancer-detection
#3
Mario R Casu, Marco Vacca, Jorge A Tobon, Azzurra Pulimeno, Imran Sarwar, Raffaele Solimene, Francesca Vipiana
Microwave imaging is an emerging breast cancer diagnostic technique, which aims at complementing already established methods like mammography, magnetic resonance imaging, and ultrasound. It offers two striking advantages: no-risk for the patient and potential low-cost for national health systems. So far, however, the prototypes developed for validation in labs and clinics used costly lab instruments such as a vector network analyzer (VNA). Moreover, the CPU time required by complex image reconstruction algorithms may not be compatible with the duration of a medical examination...
July 18, 2017: IEEE Transactions on Biomedical Circuits and Systems
https://www.readbyqxmd.com/read/28726937/novel-nanoparticles-with-cr-3-substituted-ferrite-for-self-regulating-temperature-hyperthermia
#4
Wei Zhang, Xudong Zuo, Ying Niu, Chengwei Wu, Shuping Wang, Shui Guan, S Ravi P Silva
For hyperthermia to be used under clinical conditions for cancer therapeutics the temperature regulation needs to be precise and accurately controllable. In the case of the metal nanoparticles used for such activities, a high coercivity is a prerequisite in order to couple more energy in a single heating cycle for efficient and faster differential heating. The chemically stable Co-Zn ferrite nanoparticles have typically not been used in such self-regulating hyperthermia temperature applications to date due to their low Curie temperature usually accompanied by a poor coercivity...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28723274/identifying-voxels-at-risk-for-progression-in-glioblastoma-based-on-dosimetry-physiologic-and-metabolic-mri
#5
Mekhail Anwar, Annette M Molinaro, Olivier Morin, Susan M Chang, Daphne A Haas-Kogan, Sarah J Nelson, Janine M Lupo
Despite the longstanding role of radiation in cancer treatment and the presence of advanced, high-resolution imaging techniques, delineation of voxels at-risk for progression remains purely a geometric expansion of anatomic images, missing subclinical disease at risk for recurrence while treating potentially uninvolved tissue and increasing toxicity. This remains despite the modern ability to precisely shape radiation fields. A striking example of this is the treatment of glioblastoma, a highly infiltrative tumor that may benefit from accurate identification of subclinical disease...
July 19, 2017: Radiation Research
https://www.readbyqxmd.com/read/28723064/doxorubicin-intracellular-remote-release-from-biocompatible-oegma-based-magnetic-nanogels-triggered-by-magnetic-hyperthermia
#6
Esther Cazares-Cortes, Ana Espinosa, Jean-Michel Guigner, Aude Michel, Nébéwia Griffete, Claire Wilhelm, Christine Menager
Hybrid nanogels, composed of thermoresponsive polymers and superparamagnetic nanoparticles (MNPs) are attractive nanocarriers for biomedical applications, being able - as polymer matrix - to uptake and release high quantities of chemotherapeutic agents and - as magnetic nanoparticles - to heat when exposed to an alternative magnetic field (AMF), better known as magnetic hyperthermia. Herein, biocompatible, pH-, magnetic- and thermo-responsive nanogels, based on oligo (ethylene glycol) methacrylate monomers (OEGMAs) and methacrylic acid co-monomer (MAA) were prepared by conventional precipitation radical co-polymerization in water, post-assembled by complexation with iron oxide magnetic nanoparticles (MNPs) of maghemite (-Fe2O3) and loaded with an anticancer drug (doxorubicin - DOX), for remotely controlled drug release by "hot-spot", as an athermal magnetic hyperthermia strategy against cancer...
July 19, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28721737/a-new-water-soluble-nano-micelle-through-self-assembly-pectin-curcumin-conjugates-preparation-characterization-and-anti-cancer-activity-evaluation
#7
Feng Bai, Jiajing Diao, Ying Wang, Shixin Sun, Hongmei Zhang, Yunyun Liu, Yanqing Wang, Jian Cao
Curcumin is a dominating active component of curcuma longa and has been studied widely because of its prominent biological activities. Extremely low aqueous solubility, stability and bioavailability of curcumin limits its application in the field of medicine. In this study, we developed pectin-curcumin (PEC-CCM) conjugates which could self-assemble water-soluble nano-micelles in aqueous solution. The structure of PEC-CCM conjugates was characterized by ultraviolet and visible spectra (UV-Vis), fluorescence spectra, Fourier transform infrared (FTIR) spectroscopy and 1H nuclear magnetic resonance (NMR) spectroscopy...
July 19, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28715397/magnetic-and-thermal-sensitive-poly-n-isopropylacrylamide-based-microgels-for-magnetically-triggered-controlled-release
#8
Chih-Yu Kuo, Ting-Yu Liu, Kuan-Syun Wang, Andri Hardiansyah, Yen-Ting Lin, Hsueh-Yung Chen, Wen-Yen Chiu
Magnetically and thermally sensitive poly(N-isopropylacrylamide) (PNIPAAm)/Fe3O4-NH2 microgels with the encapsulated anti-cancer drug curcumin (Cur) were designed and fabricated for magnetically triggered release. PNIPAAm-based magnetic microgels with a spherical structure were produced via a temperature-induced emulsion followed with physical-crosslinking by mixing PNIPAAm, polyethylenimine (PEI), and Fe3O4-NH2 magnetic nanoparticles. Because of their dispersity, the Fe3O4-NH2 nanoparticles were embedded inside the polymer matrix...
July 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28714565/mri-compatible-breast-rib-phantom-for-evaluating-ultrasonic-thermal-exposures
#9
Georgios Menikou, Marinos Yiannakou, Christos Yiallouras, Cleanthis Ioannides, Christakis Damianou
INTRODUCTION: The target of this study was the development of a magnetic resonance imaging (MRI) compatible breast phantom for focused ultrasound which includes plastic (ABS) ribs. The objective of the current study was the evaluation of a focused ultrasound procedure using the proposed phantom that eliminates rib heating. MATERIAL AND METHODS: The proposed phantom was evaluated using two different focused ultrasound exposures. The surrounding breast tissue was mimicked using an agar-silica-evaporation milk gel (2% w/v - 2% w/v - 40% v/v)...
July 17, 2017: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
https://www.readbyqxmd.com/read/28696514/modulation-of-lateral-positions-of-bragg-peaks-via-magnetic-fields-inside-cancer-patients-towards-magnetic-field-modulated-proton-therapy
#10
Wencheng Shao, Xiaobin Tang, Yanling Bai, Changran Geng, Diyun Shu, Chunhui Gong, Da Chen
PURPOSE: This work investigated whether the Bragg peak (BP) positions of proton beams can be modulated to produce uniform doses and cover a tumor under the magnetic fields inside cancer patients, and whether magnetic field modulated proton therapy (MMPT) is effective in vital organ protection. METHODS: The authors initially constructed an ideal water phantom comprising a central tumor surrounded by cuboid organ regions using GEANT4. Second, we designed the proton beams passing through the gap between two adjacent organ regions during beam configuration...
July 11, 2017: Medical Physics
https://www.readbyqxmd.com/read/28691219/comparison-of-reduced-field-of-view-diffusion-weighted-imaging-dwi-and-conventional-dwi-techniques-in-the-assessment-of-rectal-carcinoma-at-3-0t-image-quality-and-histological-t-staging
#11
Yang Peng, Zhen Li, Hao Tang, Yanchun Wang, Xuemei Hu, Yaqi Shen, Daoyu Hu
PURPOSE: To compare image quality (IQ) of reduced field-of-view (rFOV) and full FOV (fFOV) diffusion-weighted imaging (DWI) sequences at 3T, with histological T staging of rectal cancer as a reference standard. MATERIALS AND METHODS: In all, 81 patients with rectal cancer received magnetic resonance (MR) scans (3.0T), including both rFOV and fFOV DWI sequences. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) were quantitatively evaluated using the paired t-test...
July 10, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28688987/tumor-targeting-by-lentiviral-vectors-combined-with-magnetic-nanoparticlesin-mice
#12
Ester Borroni, Marta Miola, Sara Ferraris, Giulia Ricci, Kristina ŽužekRožman, Nina Kostevšek, Angela Catizone, Lia Rimondini, Maria Prat, Enrica Verné, Antonia Follenzi
Nanomaterials conjugated or complexed with biological moieties such as antibodies, polymers or peptides appear to be suitable not only for drug delivery but also for specific cancer treatment. Here, biocompatible iron oxide magnetic nanoparticles (MNPs) with or without a silica shell coupled with lentiviral vectors (LVs) are proposed as a combined therapeutic approach to specifically target gene expression in a cancer mouse model. Initially, four different MNPs were synthesized and their physical properties were characterized to establish and discriminate their behaviors...
July 5, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28685419/joint-deformable-liver-registration-and-bias-field-correction-for-mr-guided-hdr-brachytherapy
#13
Marko Rak, Tim König, Klaus D Tönnies, Mathias Walke, Jens Ricke, Christian Wybranski
PURPOSE: In interstitial high-dose rate brachytherapy, liver cancer is treated by internal radiation, requiring percutaneous placement of applicators within or close to the tumor. To maximize utility, the optimal applicator configuration is pre-planned on magnetic resonance images. The pre-planned configuration is then implemented via a magnetic resonance-guided intervention. Mapping the pre-planning information onto interventional data would reduce the radiologist's cognitive load during the intervention and could possibly minimize discrepancies between optimally pre-planned and actually placed applicators...
July 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28681208/surgical-considerations-in-the-optimal-management-of-patients-with-malignant-brain-tumors
#14
REVIEW
Jaclyn J Renfrow, Roy E Strowd, Adrian W Laxton, Stephen B Tatter, Carol P Geer, Glenn J Lesser
Advances in technology are revolutionizing medicine and the limits of what we can offer to our patients. In neurosurgery, technology continues to reduce morbidity, increase surgical accuracy, facilitate tissue acquisition, and promote novel techniques for prolonging survival in patients with neuro-oncologic disease. Surgery has been the backbone of glioma diagnosis and treatment by providing adequate, high quality material for precise histologic diagnosis, and genomic characterization in the setting of significant intratumoral heterogeneity, thus allowing personalized treatment selection in the clinic...
August 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28678383/the-role-of-early-magnetic-resonance-imaging-in-predicting-survival-on-bevacizumab-for-recurrent-glioblastoma-results-from-a-prospective-clinical-trial-cabaret
#15
Kathryn M Field, Pramit M Phal, Greg Fitt, Christine Goh, Anna K Nowak, Mark A Rosenthal, John Simes, Elizabeth H Barnes, Kate Sawkins, Lawrence M Cher, Elizabeth J Hovey, Helen Wheeler
BACKGROUND: Bevacizumab has been associated with prolonged progression-free survival for patients with recurrent glioblastoma; however, not all derive a benefit. An early indicator of efficacy or futility may allow early discontinuation for nonresponders. This study prospectively assessed the role of early magnetic resonance imaging (eMRI) and its correlation with subsequent routine magnetic resonance imaging (MRI) results and survival. METHODS: Patients were part of a randomized phase 2 clinical trial (CABARET) comparing bevacizumab with bevacizumab plus carboplatin for recurrent glioblastoma...
July 5, 2017: Cancer
https://www.readbyqxmd.com/read/28675377/investigation-of-novel-superparamagnetic-ni0-5zn0-5fe2o4-albumen-nanoparticles-for-controlled-delivery-of-anti-cancer-drug
#16
M Qasim, Khushnuma Asghar, Gangappa Dharmapuri, Dibakar Das
In the present work, multifunctional Ni0.5Zn0.5Fe2O4@albumen (NZF@Alb) and doxorubicin loaded Ni0.5Zn0.5Fe2O4@albumen (NZF@Alb-Dox) core-shell nanoparticles have been prepared by a green and simple method using inexpensive chicken egg albumen and have been characterized for different physiochemical properties. The structural, morphological, thermal and magnetic properties of the prepared nanoparticles have been investigated by XRD, HRTEM, FESEM, FTIR, TGA, and VSM techniques. Superparamagnetic Ni0.5Zn0.5Fe2O4 nanoparticles (NZF NPs) with the mean size ~20 nm was coated with albumen matrix by an ultrasonication process...
July 4, 2017: Nanotechnology
https://www.readbyqxmd.com/read/28670174/systematic-review-on-the-accuracy-of-positron-emission-tomography-computed-tomography-and-positron-emission-tomography-magnetic-resonance-imaging-in-the-management-of-ovarian-cancer-is-functional-information-really-needed
#17
REVIEW
Subapriya Suppiah, Wing Liong Chang, Hasyma Abu Hassan, Chalermrat Kaewput, Andi Anggeriana Andi Asri, Fathinul Fikri Ahmad Saad, Abdul Jalil Nordin, Sobhan Vinjamuri
Ovarian cancer (OC) often presents at an advanced stage with frequent relapses despite optimal treatment; thus, accurate staging and restaging are required for improving treatment outcomes and prognostication. Conventionally, staging of OC is performed using contrast-enhanced computed tomography (CT). Nevertheless, recent advances in the field of hybrid imaging have made positron emission tomography/CT (PET/CT) and PET/magnetic resonance imaging (PET/MRI) as emerging potential noninvasive imaging tools for improved management of OC...
July 2017: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/28661430/analysis-of-hypericin-mediated-effects-and-implications-for-targeted-photodynamic-therapy
#18
Laura Mühleisen, Magdalena Alev, Harald Unterweger, Daniel Subatzus, Marina Pöttler, Ralf P Friedrich, Christoph Alexiou, Christina Janko
The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prevent unwanted activation of the drug in other regions of the body, patients have to avoid light during and after the treatment cycles, consequently impairing quality of life. Here, we characterize toxicity and hypericin-mediated effects on cancer cells in vitro and confirm that its effect clearly depends on concentration and illumination time...
June 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28652596/magnetic-particles-with-perpendicular-anisotropy-for-mechanical-cancer-cell-destruction
#19
Rhodri Mansell, Tarun Vemulkar, Dorothée C M C Petit, Yu Cheng, Jason Murphy, Maciej S Lesniak, Russell P Cowburn
We demonstrate the effectiveness of out-of-plane magnetized magnetic microdiscs for cancer treatment through mechanical cell disruption under an applied rotating magnetic field. The magnetic particles are synthetic antiferromagnets formed from a repeated motif of ultrathin CoFeB/Pt layers. In-vitro studies on glioma cells are used to compare the efficiency of the CoFeB/Pt microdiscs with Py vortex microdiscs. It is found that the CoFeB/Pt microdiscs are able to damage 62 ± 3% of cancer cells compared with 12 ± 2% after applying a 10 kOe rotating field for one minute...
June 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28641813/sensors-and-bioassays-powered-by-upconverting-materials
#20
REVIEW
Diego Mendez-Gonzalez, Enrique Lopez-Cabarcos, Jorge Rubio-Retama, Marco Laurenti
In recent years, considerable efforts have been done to better understand the peculiar emission properties of upconverting materials due to their widespread applications in different and important technological fields such as upconversion-based photoactivated cancer therapies, photoactivated drug-delivery, magnetic resonance imaging contrast agents, bioimaging. However, one of the most promising applications of upconverting materials concerns the field of sensing, due to their unique emission properties. In fact, the minimal autofluorescence, blinking, photo-bleaching, and high photostability makes them an excellent alternative to organic dyes or quantum dots...
June 10, 2017: Advances in Colloid and Interface Science
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