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https://www.readbyqxmd.com/read/29165872/manganese-dioxide-coated-ws2-fe3-o4-ssio2-nanocomposites-for-ph-responsive-mr-imaging-and-oxygen-elevated-synergetic-therapy
#1
Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu
Recently, the development of multifunctional theranostic nanoplatforms to realize tumor-specific imaging and enhanced cancer therapy via responding or modulating the tumor microenvironment (TME) has attracted tremendous interests in the field of nanomedicine. Herein, tungsten disulfide (WS2 ) nanoflakes with their surface adsorbed with iron oxide nanoparticles (IONPs) via self-assembly are coated with silica and then subsequently with manganese dioxide (MnO2 ), on to which polyethylene glycol (PEG) is attached...
November 22, 2017: Small
https://www.readbyqxmd.com/read/29158849/enhanced-antitumor-efficacy-of-biocompatible-magnetosomes-for-the-magnetic-hyperthermia-treatment-of-glioblastoma
#2
Raphaël Le Fèvre, Mickaël Durand-Dubief, Imène Chebbi, Chalani Mandawala, France Lagroix, Jean-Pierre Valet, Ahmed Idbaih, Clovis Adam, Jean-Yves Delattre, Charlotte Schmitt, Caroline Maake, François Guyot, Edouard Alphandéry
In this study, biologically synthesized iron oxide nanoparticles, called magnetosomes, are made fully biocompatible by removing potentially toxic organic bacterial residues such as endotoxins at magnetosome mineral core surfaces and by coating such surface with poly-L-lysine, leading to magnetosomes-poly-L-lysine (M-PLL). M-PLL antitumor efficacy is compared with that of chemically synthesized iron oxide nanoparticles (IONPs) currently used for magnetic hyperthermia. M-PLL and IONPs are tested for the treatment of glioblastoma, a dreadful cancer, in which intratumor nanoparticle administration is clinically relevant, using a mouse allograft model of murine glioma (GL-261 cell line)...
2017: Theranostics
https://www.readbyqxmd.com/read/29157069/tumor-volume-regression-during-preoperative-chemoradiotherapy-for-rectal-cancer-a-prospective-observational-study-with-weekly-mri
#3
Robbe Van den Begin, Jean-Paul Kleijnen, Benedikt Engels, Marielle Philippens, Bram van Asselen, Bas Raaymakers, Onne Reerink, Mark De Ridder, Martijn Intven
PURPOSE: Few data is available on rectal tumor shrinkage during preoperative chemoradiotherapy (CRT). This regression pattern is interesting to optimize timing of dose escalation on the tumor. METHODS: Gross tumor volumes (GTV) were contoured by two observers on magnetic resonance imaging (MRI) obtained before, weekly during, 2-4 weeks after, and 7-8 weeks after a 5-week course of concomitant CRT for rectal cancer. RESULTS: Overall, 120 MRIs were acquired in 15 patients...
November 20, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29156126/two-dimensional-tantalum-carbide-mxenes-composite-nanosheets-for-multiple-imaging-guided-photothermal-tumor-ablation
#4
Chen Dai, Yu Chen, Xiangxiang Jing, Lihua Xiang, Dayang Yang, Han Lin, Zhuang Liu, Xiaoxia Han, Rong Wu
MXenes, an emerging family of graphene-analogues two-dimensional (2D) materials, have attracted continuous and tremendous attentions in many application fields because of their intrinsic physiochemical properties and high performance in versatile applications. In this work, we report on the construction of tantalum carbide (Ta4C3) MXene-based composite nanosheets for multiple imaging-guided photothermal tumor ablation, which has been achieved by rational choice of the composition of MXenes and their surface functionalization...
November 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/29155407/synthesis-of-porous-gdf3-er-3-yb-3-cooh-core-shell-structured-bi-functional-nanoparticles-for-drug-delivery
#5
Hongxia Peng, Ouyang Jundai, Jin Wen, Yangxi Peng
The authors synthesised porous GdF3:Er(3+),Yb(3+)-COOH core-shell structured bi-functional nanoparticles through a one-step hydrothermal route during which ethylene diamine tetraacetic acid) was bound to the surface of the nanoparticles. It has high up-conversion emission intensity for monitoring the drug release process and magnetisation saturation value (10.2 emu/g) for drug targeting under foreign magnetic fields. Moreover, porous GdF3:Er(3+),Yb(3+) as drug carriers with a high drug-loading efficiency...
December 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/29154535/novel-gd-loaded-silicon-nanohybrid-a-potential-egfr-expressing-cancer-cell-targeting-mri-contrast-agent
#6
Sougata Sinha, Wing Yin Tong, Nathan H Williamson, Steven James Peter McInnes, Simon Puttick, Anna Cifuentes-Rius, Richa Bhardwaj, Sally E Plush, Nicolas H Voelcker
Continuing our research efforts in developing mesoporous silicon nanoparticle based biomaterials for cancer therapy, here we employed porous silicon nanoparticles as a nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule Gd-chelates (L1-Gd) enhanced the T1 contrast dramatically compared to distinct Gd-chelate (L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules and their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on silicon nanostructures and conjugated to an antibody specific for epidermal growth factor receptor (EGFR) via a hydrazone linkage...
November 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29138559/human-mesenchymal-stem-cell-derived-iron-oxide-exosomes-allow-targeted-ablation-of-tumor-cells-via-magnetic-hyperthermia
#7
U Altanerova, M Babincova, P Babinec, K Benejova, J Jakubechova, V Altanerova, M Zduriencikova, V Repiska, C Altaner
Magnetic hyperthermia, or the heating of tissues using magnetic materials, is a promising approach for treating cancer. We found that human mesenchymal stem cells (MSCs) isolated from various tissues and MSCs expressing the yeast cytosine deaminase∷uracil phosphoribosyl transferase suicide fusion gene (yCD∷UPRT) can be labeled with Venofer, an iron oxide carbohydrate nanoparticle. Venofer labeling did not affect cell proliferation or the ability to home to tumors. All Venofer-labeled MSCs released exosomes that contained iron oxide...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29136725/-the-china-expert-consensus-of-clinical-practice-for-magnetically-controlled-capsule-gastroscopy-2017-shanghai
#8
(no author information available yet)
Gastric diseases are very common in China, especially gastric cancer with a continuous high level of morbidity and mortality. As an important screening method of gastric diseases, magnetically-controlled-capsule-gastroscopy (MCCG) has already been widely used in medical institutions worldwide. Several clinical trials have already showed that MCCG has comparable accuracy in diagnosing gastric diseases compared with conventional gastroscopy. Furthermore, MCCG has the advantages of anesthesia free, no risks of cross infection, and excellent compliance...
November 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/29135000/bioconjugated-fluorescent-organic-nanoparticles-targeting-egfr-overexpressing-cancer-cells
#9
Adrien Faucon, Houda Benhelli-Mokrani, Fabrice Fleury, Stéphanie Dutertre, Marc Tramier, Joanna Boucard, Lénaïc Lartigue, Steven Nedellec, Philippe Hulin, Eléna Ishow
The field of optical bioimaging has considerably flourished with the advent of sophisticated microscopy techniques and ultra-bright fluorescent tools. Fluorescent organic nanoparticles (FONs) have thus recently appeared as very attractive labels for their high payload, absence of cytotoxicity and eventual biodegradation. Nevertheless, their bioconjugation to target specific receptors with high imaging contrast is scarcely performed. Moreover, assessing the reality of bioconjugation represents high challenges given the sub-nanomolar concentrations resulting from the commonly adopted nanoprecipitation fabrication process...
November 14, 2017: Nanoscale
https://www.readbyqxmd.com/read/29130334/pulsed-epr-imaging-applications-in-the-studies-of-tumor-physiology
#10
Shun Kishimoto, Ken-Ichiro Matsumoto, Keita Saito, Ayano Enomoto, Shingo Matsumoto, James Mitchell, Nallathamby Devasahayam, Murali C Krishna
SIGNIFICANCE: Electron Paramagnetic Resonance imaging (EPRI) is a powerful technique capable of generating images of tissue oxygenation using exogenous paramagnetic probes such as trityl radicals or nitroxyl radicals. Using principles similar to Magnetic Resonance Imaging (MRI) with field gradients, the spatial distribution of the paramagnetic probecan be generatedand,from its spectral features, spatial maps of oxygen can be obtained from live objects. In this review, two methods of signal acquisition, image formation/reconstruction will be described...
November 12, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#11
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29093500/shape-tailored-magnetic-nanorings-for-intracellular-hyperthermia-cancer-therapy
#12
Carlos S B Dias, Talita D M Hanchuk, Heberton Wender, Willian T Shigeyosi, Jörg Kobarg, André L Rossi, Marcelo N Tanaka, Mateus B Cardoso, Flávio Garcia
This work explores a new class of vortex/magnetite/iron oxide nanoparticles designed for magnetic hyperthermia applications. These nanoparticles, named Vortex Iron oxide Particles (VIPs), are an alternative to the traditional Superparamagnetic Iron Oxide Nanoparticles (SPIONs), since VIPs present superior heating power while fulfilling the main requirements for biomedical applications (low cytotoxicity and nonremanent state). In addition, the present work demonstrates that the synthesized VIPs also promote an internalization and aggregation of the particles inside the cell, resulting in a highly localized hyperthermia in the presence of an alternating magnetic field...
November 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29090673/pet-ct-with-68ga-psma-in-prostate-cancer-radiopharmaceutical-background-and-clinical-implications
#13
Giampiero Giovacchini, Elisabetta Giovannini, Mattia Riondato, Andrea Ciarmiello
In the last twenty years, positron emission tomography / computed tomography (PET/CT) with radiolabeled choline, represented the most powerful imaging modality for prostate cancer (PCa). However, the low positive detection rate of the technique for PSA < 1 ng/ml prompted the development of other tracers for imaging PCa. 68Ga-PSMA is a receptor ligand tracer, which has been identified as the most promising radiopharmaceutical for imaging PCa. The most promising feature of this radiopharmaceutical is the high positive detection rate for prostate specific antigen (PSA) levels < 1 ng/ml or less (i...
November 1, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29076458/feasibility-of-mr-only-proton-dose-calculations-for-prostate-cancer-radiotherapy-using-a-commercial-pseudo-ct-generation-method
#14
Matteo Maspero, Cornelis A T Van den Berg, Guillaume Landry, Claus Belka, Katia Parodi, Peter R Seevinck, Bas W Raaymakers, Christopher Kurz
A magnetic resonance (MR)-only radiotherapy workflow can reduce cost, radiation exposure and uncertainties introduced by CT-MRI registration. A crucial prerequisite is generating the so called pseudo-CT (pCT) images for accurate dose calculation and planning. Many pCT generation methods have been proposed in the scope of photon radiotherapy. This work aims at verifying for the first time whether a commercially available photon-oriented pCT generation method can be employed for accurate intensity-modulated proton therapy (IMPT) dose calculation...
October 27, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29075487/magnetic-nanoparticles-in-cancer-diagnosis-drug-delivery-and-treatment
#15
Meijia Wu, Shengwu Huang
In recent years, magnetic nanoparticles (MNPs) have demonstrated marked progress in the field of oncology. General nanoparticles are widely used in tumor targeting, and the intrinsic magnetic property of MNPs makes them the most promising nanomaterial to be used as contrast agents for magnetic resonance imaging (MRI) and induced magnetic hyperthermia. The properties of MNPs are fully exploited when they are used as drug delivery agents, wherein drugs may be targeted to the desired specific location in vivo by application of an external magnetic field...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29072442/microwave-absorption-and-the-magnetic-hyperthermia-applications-of-li0-3zn0-3co0-1fe2-3o4-nanoparticles-in-multiwalled-carbon-nanotube-matrix
#16
Madhumita Dalal, Jean-Marc Greneche, Biswarup Satpati, Tayssir B Ghzaiel, Frédric Mazaleyrat, Raghumani S Ningthoujam, Pabitra K Chakrabarti
Nanoparticles of Li0.3Zn0.3Co0.1Fe2.3O4 (LZC) were prepared by the sol-gel method and dried in a furnace at ∼200 °C. The dried sample was annealed at 500, 600, 700, and 800 °C for 5 h each. Rietveld analysis of X-ray diffraction patterns confirms the cubic Fd3̅m phase formation with lattice parameters ranged from 8.376 up to 8.390 Å and allows the crystallite sizes (dcryst) to be estimated. To enhance microwave (MW) absorption as well as the effectiveness for hyperthermia treatment, nanoparticles are taken in the matrix of multiwalled carbon nanotubes (MWCNTs) and the morphology of the so-prepared samples (LZC@MWCNT) was studied by scanning electron microscopy and transmission electron microscopy analyses...
November 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29071179/novel-hyaluronic-acid-conjugates-for-dual-nuclear-imaging-and-therapy-in-cd44-expressing-tumors-in-mice-in-vivo
#17
Ravindra Dhar Dubey, Rebecca Klippstein, Julie Tzu-Wen Wang, Naomi Hodgins, Kuo-Ching Mei, Jane Sosabowski, Robert C Hider, Vincenzo Abbate, Prem N Gupta, Khuloud T Al-Jamal
Hyaluronic acid, a natural CD44 receptor ligand, has attracted attention in the past years as a macromolecular delivery of anticancer agents to cancer. At the same time, the clinical applications of Gemcitabine (Gem) have been hindered by its short biological half-life, high dose and development of drug resistance. This work reports the synthesis of a hyaluronic acid (HA) conjugate for nuclear imaging, and in vivo Gem delivery to CD44-expressing solid tumors in mice. HA was individually conjugated, via amide coupling, to Gem (HA-Gem), 4'-(aminomethyl)fluorescein hydrochloride (HA-4'-AMF) or tris(hydroxypyridinone) amine (HA-THP) for cancer therapy, in vitro tracking or single photon emission computed tomography/computed tomography (SPECT/CT) imaging, respectively...
2017: Nanotheranostics
https://www.readbyqxmd.com/read/29066887/melatonin-potentiates-inside-out-nano-thermotherapy-in-human-breast-cancer-cells-a-potential-cancer-target-multimodality-treatment-based-on-melatonin-loaded-nanocomposite-particles
#18
Wensheng Xie, Qin Gao, Dan Wang, Wei Wang, Jie Yuan, Zhenhu Guo, Hao Yan, Xiumei Wang, Xiaodan Sun, Lingyun Zhao
PURPOSE: With the wide recognition of oncostatic effect of melatonin, the current study proposes a potential breast cancer target multimodality treatment based on melatonin-loaded magnetic nanocomposite particles (Melatonin-MNPs). METHODS: Melatonin-MNPs were fabricated by the single emulsion solvent extraction/evaporation method. RESULTS: Based on the facilitated transport of melatonin by the GLUT overexpressed on the cell membrane, such Melatonin-MNPs can be more favorably uptaken by MCF-7 cells compared with the melatonin-free nanocomposite particles, which indicates the cancer targeting ability of melatonin molecule...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29066121/patterns-of-intraosseous-recurrence-after-stereotactic-body-radiation-therapy-for-coxal-bone-metastasis
#19
Kei Ito, Takuya Shimizuguchi, Keiji Nihei, Tomohisa Furuya, Hiroaki Ogawa, Hiroshi Tanaka, Keisuke Sasai, Katsuyuki Karasawa
PURPOSE: To analyze the detailed pattern of intraosseous failure after stereotactic body radiation therapy (SBRT) for coxal bone metastasis. METHODS AND MATERIALS: Patients treated with SBRT to coxal bone metastasis were identified by retrospective chart review. The SBRT doses were 30 Gy or 35 Gy in 5 fractions. A margin of 5 to 10 mm was added to the gross tumor volume to create the clinical target volume. We evaluated the presence or absence of intraosseous recurrence using magnetic resonance imaging...
September 5, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29064573/effects-of-magnetic-field-orientation-and-strength-on-the-treatment-planning-of-non-small-cell-lung-cancer
#20
Oliver Schrenk, Claudia Katharina Spindeldreier, Lucas Norberto Burigo, Juliane Hoerner-Rieber, Asja Pfaffenberger
PURPOSE: Magnetic resonance image-guided radiotherapy (MRgRT) has the potential to increase the accuracy of radiation treatment delivery. Several research groups have developed hybrid MRgRT devices differing by radiation source used, magnetic field orientation and strength. In this work, we investigate the impact of different magnetic field orientations and strengths on the treatment planning of non-small cell lung cancer patients (NSCLC). METHODS: A framework using the in-house developed treatment planning system matRad and the EGSnrc Monte Carlo code system was introduced to perform Monte Carlo based treatment planning in the presence of a magnetic field...
October 24, 2017: Medical Physics
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