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https://www.readbyqxmd.com/read/28809987/label-free-ferrohydrodynamic-cell-separation-of-circulating-tumor-cells
#1
Wujun Zhao, Rui Cheng, Brittany D Jenkins, Taotao Zhu, Nneoma E Okonkwo, Courtney E Jones, Melissa B Davis, Sravan K Kavuri, Zhonglin Hao, Carsten Schroeder, Leidong Mao
Circulating tumor cells (CTCs) have significant implications in both basic cancer research and clinical applications. To address the limited availability of viable CTCs for fundamental and clinical investigations, effective separation of extremely rare CTCs from blood is critical. Ferrohydrodynamic cell separation (FCS), a label-free method that conducted cell sorting based on cell size difference in biocompatible ferrofluids, has thus far not been able to enrich low-concentration CTCs from cancer patients' blood because of technical challenges associated with processing clinical samples...
August 15, 2017: Lab on a Chip
https://www.readbyqxmd.com/read/28801095/fabrication-of-chitosan-poly-lactic-acid-graphene-oxide-tio2-composite-nanofibrous-scaffolds-for-sustained-delivery-of-doxorubicin-and-treatment-of-lung-cancer
#2
Saman Samadi, Mahboubeh Moradkhani, Hoda Beheshti, Mohammad Irani, Majid Aliabadi
In this work, the synthesized graphene oxide/TiO2/doxorubicin (GO/TiO2/DOX) composites were loaded into the chitosan/poly(lactic acid) (PLA) solutions to fabricate the electrospun chitosan/PLA/GO/TiO2/DOX nanofibrous scaffolds via electrospinning process. The synthesized composites and nanofibers were characterized using X-ray powder diffraction (XRD), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis. Three-factor three-level central composite design was used to determine the influence of PLA to chitosan ratio, TiO2/DOX content and GO/TiO2/DOX content on the release of DOX from nanofibrous scaffolds...
August 8, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28800298/impact-of-field-number-and-beam-angle-on-functional-image-guided-lung-cancer-radiotherapy-planning
#3
Bilal A Tahir, Chris M Bragg, Jim M Wild, James A Swinscoe, Sarah E Lawless, Kerry A Hart, Matthew Q Hatton, Rob H Ireland
To investigate the effect of beam angles and field number on functionally-guided intensity modulated radiotherapy (IMRT) normal lung avoidance treatment plans that incorporate hyperpolarised helium-3 magnetic resonance imaging ((3)He MRI) ventilation data. Eight non-small cell lung cancer patients had pre-treatment (3)He MRI that was registered to inspiration breath-hold radiotherapy planning computed tomography. IMRT plans that minimised the volume of total lung receiving  ⩾20 Gy (V20) were compared with plans that minimised (3)He MRI defined functional lung receiving  ⩾20 Gy (fV20)...
August 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28789518/theranostic-iron-oxide-gold-ion-nanoprobes-for-mr-imaging-and-non-invasive-rf-hyperthermia
#4
Sajid Fazal, Bindhu Paul-Prasanth, Shantikumar Nair, Deepthy Menon
This work focuses on the development of a nanoparticulate system that can be used for MR imaging and E-field non-invasive radiofrequency (RF) hyperthermia. For this purpose, an amine-functional gold ion complex, (GIC) [Au(III)(diethylenetriamine)Cl]Cl2 which generates heat upon RF exposure, was conjugated to carboxyl functional polyacrylic acid capped iron-oxide nanoparticles (IO-PAA NPs) to form IO-GIC NPs of size ~100 nm. The multimodal superparamagnetic IO-GIC NPs produced T2-contrast on MR imaging and unlike IO-PAA NPs, generated heat on RF exposure...
August 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28774062/targeted-magnetic-nanoparticles-for-mechanical-lysis-of-tumor-cells-by-low-amplitude-alternating-magnetic-field
#5
Adi Vegerhof, Eran A Barnoy, Menachem Motiei, Dror Malka, Yossef Danan, Zeev Zalevsky, Rachela Popovtzer
Currently available cancer therapies can cause damage to healthy tissue. We developed a unique method for specific mechanical lysis of cancer cells using superparamagnetic iron oxide nanoparticle rotation under a weak alternating magnetic field. Iron oxide core nanoparticles were coated with cetuximab, an anti-epidermal growth factor receptor antibody, for specific tumor targeting. Nude mice bearing a head and neck tumor were treated with cetuximab-coated magnetic nanoparticles (MNPs) and then received a 30 min treatment with a weak external alternating magnetic field (4 Hz) applied on alternating days (total of seven treatments, over 14 days)...
November 22, 2016: Materials
https://www.readbyqxmd.com/read/28764995/magnetically-responsive-microbubbles-as-delivery-vehicles-for-targeted-sonodynamic-and-antimetabolite-therapy-of-pancreatic-cancer
#6
Yingjie Sheng, Estelle Beguin, Heather Nesbitt, Sukanta Kamila, Joshua Owen, Lester C Barnsley, Bridgeen Callan, Christopher O'Kane, Nikolitsa Nomikou, Rifat Hamoudi, Mark A Taylor, Mark Love, Paul Kelly, Declan O'Rourke, Eleanor Stride, Anthony P McHale, John F Callan
Magnetically responsive microbubbles (MagMBs), consisting of an oxygen gas core and a phospholipid coating functionalised with Rose Bengal (RB) and/or 5-fluorouracil (5-FU), were assessed as a delivery vehicle for the targeted treatment of pancreatic cancer using combined antimetabolite and sonodynamic therapy (SDT). MagMBs delivering the combined 5-FU/SDT treatment produced a reduction in cell viability of over 50% when tested against a panel of four pancreatic cancer cell lines in vitro. Intravenous administration of the MagMBs to mice bearing orthotopic human xenograft BxPC-3 tumours yielded a 48...
July 29, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28764539/magnetic-induction-of-hyperthermia-by-a-modified-self-learning-fuzzy-temperature-controller
#7
Wei-Cheng Wang, Cheng-Chi Tai
The aim of this study involved developing a temperature controller for magnetic induction hyperthermia (MIH). A closed-loop controller was applied to track a reference model to guarantee a desired temperature response. The MIH system generated an alternating magnetic field to heat a high magnetic permeability material. This wireless induction heating had few side effects when it was extensively applied to cancer treatment. The effects of hyperthermia strongly depend on the precise control of temperature. However, during the treatment process, the control performance is degraded due to severe perturbations and parameter variations...
July 2017: Review of Scientific Instruments
https://www.readbyqxmd.com/read/28755383/solid-bone-tumors-of-the-spine-diagnostic-performance-of-apparent-diffusion-coefficient-measured-using-diffusion-weighted-mri-using-histology-as-a-reference-standard
#8
Grazia Pozzi, Domenico Albano, Carmelo Messina, Salvatore Alessio Angileri, Asma'a Al-Mnayyis, Fabio Galbusera, Alessandro Luzzati, Giuseppe Perrucchini, Gennaro Scotto, Antonina Parafioriti, Alberto Zerbi, Luca Maria Sconfienza
PURPOSE: To assess the diagnostic performance of mean apparent diffusion coefficient (mADC) in differentiating benign from malignant bone spine tumors, using histology as a reference standard. Conventional magnetic resonance imaging (MRI) sequences have good reliability in evaluating spinal bone tumors, although some features of benign and malignant cancers may overlap, making the differential diagnosis challenging. MATERIALS AND METHODS: In all, 116 patients (62 males, 54 females; mean age 59...
July 29, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28753844/transcriptome-wide-analysis-of-magnetic-resonance-imaging-targeted-biopsy-and-matching-surgical-specimens-from-high-risk-prostate-cancer-patients-treated-with-radical-prostatectomy-the-target-must-be-hit
#9
Jan Philipp Radtke, Mandeep Takhar, David Bonekamp, Claudia Kesch, Nicholas Erho, Marguerite du Plessis, Christine Buerki, Kaye Ong, Elai Davicioni, Markus Hohenfellner, Boris A Hadaschik
BACKGROUND: The most suspicious lesions on multiparametric magnetic resonance imaging (MRI) may be representative of final pathology. OBJECTIVE: We connect imaging with high-precision spatial annotation of biopsies and genomic cancer signatures to compare the genomic signals of the index lesion and biopsy cores of adjacent and far away locations. DESIGN, SETTING, AND PARTICIPANTS: Eleven patients diagnosed with high-risk prostate cancer on MRI/transrectal ultrasound-fusion biopsy (Bx) and treated with radical prostatectomy (RP)...
January 26, 2017: European Urology Focus
https://www.readbyqxmd.com/read/28752179/-clinical-autopsies-in-switzerland-a-status-report
#10
REVIEW
A-K Rodewald, P Bode, G Cathomas, H Moch
BACKGROUND: The number of autopsies has been steadily declining worldwide over the past decades. The reasons for this are diverse. Legislation regarding opposition and consent rules does not appear to have had a significant impact on the autopsy rates. Above all, structural causes and the attitude of the medical profession are the reasons for this decline. The main argument for a high autopsy rate is the identification of diagnostic errors; however, diagnostic discrepancies are relatively independent of the rate of autopsies performed...
July 27, 2017: Der Pathologe
https://www.readbyqxmd.com/read/28752174/transferrin-coated-magnetic-upconversion-nanoparticles-for-efficient-photodynamic-therapy-with-near-infrared-irradiation-and-luminescence-bioimaging
#11
Dan Wang, Lin Zhu, Yuan Pu, Jie-Xin Wang, Jian-Feng Chen, Liming Dai
In the present study, we devised a green-synthesis route to NaYF4:Gd(3+),Yb(3+),Er(3+) upconversion nanoparticles (UCNPs) by using eco-friendly paraffin liquid, instead of 1-octadecene, as a high boiling non-coordinating solvent. A multifunctional nanoplatform was then developed by coating UCNPs with biocompatible transferrin (TRF) for magnetically-assisted and near-infrared light induced photodynamic therapy and bioimaging. Protoporphyrin IX (PpIX), a clinically approved photodynamic therapy agent, was loaded into the shell layer of the TRF-coated UCNPs (UCNP@TRF nanoparticles), which can be efficiently taken up by cancer cells for photodynamic therapy...
July 28, 2017: Nanoscale
https://www.readbyqxmd.com/read/28751720/experimental-estimation-and-analysis-of-variance-of-the-measured-loss-power-of-magnetic-nanoparticles
#12
Frederik Soetaert, Sri Kamal Kandala, Andris Bakuzis, Robert Ivkov
Magnetic nanoparticles dissipate heat when exposed to alternating magnetic fields (AMFs), making them suitable for cancer hyperthermia. Therapeutic heating applications demand accurate characterization of the heating power dissipated by the particles. Specific loss power (SLP) generated by magnetic nanoparticles is estimated from calorimetric heating measurements. Such measurements require adiabatic conditions, yet they are typically performed in an AMF device with non-adiabatic conditions. We have measured heating from four magnetic nanoparticle constructs using a range of frequencies (150-375 kHz) and magnetic fields (4-44 kA/m)...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28743275/block-copolymer-conjugated-au-coated-fe3o4-nanoparticles-as-vectors-for-enhancing-colloidal-stability-and-cellular-uptake
#13
Junbo Li, Sheng Zou, Jiayu Gao, Ju Liang, Huiyun Zhou, Lijuan Liang, Wenlan Wu
BACKGROUND: Polymer surface-modified inorganic nanoparticles (NPs) provide a multifunctional platform for assisting gene delivery. Rational structure design for enhancing colloidal stability and cellular uptake is an important strategy in the development of safe and highly efficient gene vectors. RESULTS: Heterogeneous Au-coated Fe3O4 (Fe3O4@Au) NPs capped by polyethylene glycol-b-poly1-(3-aminopropyl)-3-(2-methacryloyloxy propylimidazolium bromine) (PEG-b-PAMPImB-Fe3O4@Au) were prepared for DNA loading and magnetofection assays...
July 25, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28741689/superparamagnetic-gold-nanoparticles-synthesized-on-protein-particle-scaffolds-for-cancer-theragnosis
#14
Koo Chul Kwon, Eunji Jo, Young-Wan Kwon, Boram Lee, Ju Hee Ryu, Eun Jung Lee, Kwangmeyung Kim, Jeewon Lee
Cancer theragnosis using a single multimodality agent is the next mainstay of modern cancer diagnosis, treatment, and management, but a clinically feasible agent with in vivo cancer targeting and theragnostic efficacy has not yet been developed. A new type of cancer theragnostic agent is reported, based on gold magnetism that is induced on a cancer-targeting protein particle carrier. Superparamagnetic gold-nanoparticle clusters (named SPAuNCs) are synthesized on a viral capsid particle that is engineered to present peptide ligands targeting a tumor cell receptor (TCR)...
July 25, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28741458/hybrid-polymeric-magnetic-nanoparticles-in-cancer-treatments
#15
Alexandra Muñoz Bonilla, Pilar Herrasti González
Over the last years, magnetic nanoparticles have received a great attention in cancer therapy and diagnosis. Magnetic drug targeting, is a particularly promising application in this area as the nanoparticles can be directed to the tumor by external magnetic field and concentrated the drug in this tumor tissue. In addition to this magnetic targeting, their inherent magnetic properties provide sensitive contrast enhancement in magnetic resonance imaging (MRI) and can, therefore, be visualized and used for theranostic purposes...
May 18, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28740950/lymphedema-from-diagnosis-to-treatment
#16
REVIEW
Oğuz Kayıran, Carolyn De La Cruz, Kaori Tane, Atilla Soran
Lymphedema is a chronic and progressive disorder resulting from impaired lymphatic system function. In developed countries, upper extremity lymphedema is mainly the consequence of breast cancer surgery in which axillary lymph node dissection and radiation alter upper extremity lymphatic flow. Diagnosis of lymphedema is made clinically. Nevertheless, there are numerous diagnostic tools available for disease staging. Recently, a new technology namely magnetic resonance lymphangiography has emerged in the medical field to assist in both diagnosis and management...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28740928/magnetic-resonance-imaging-guided-reirradiation-of-recurrent-and-second-primary-head-and-neck-cancer
#17
Allen M Chen, Minsong Cao, Sophia Hsu, James Lamb, Argin Mikaeilian, Yingli Yang, Nzhde Agazaryan, Daniel A Low, Michael L Steinberg
PURPOSE: To report a single-institutional experience using magnetic resonance imaging (MRI) guided radiation therapy for the reirradiation of recurrent and second cancers of the head and neck. METHODS AND MATERIALS: Between October 2014 and August 2016, 13 consecutive patients with recurrent or new primary cancers of the head and neck that occurred in a previously irradiated field were prospectively enrolled in an institutional registry trial to investigate the feasibility and efficacy of MRI guided radiation therapy using a 0...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28732311/solid-and-aqueous-magnetoliposomes-as-nanocarriers-for-a-new-potential-drug-active-against-breast-cancer
#18
Ana Rita O Rodrigues, Pedro M F Mendes, Pedro M L Silva, V A Machado, Bernardo G Almeida, J P Araújo, Maria-João R P Queiroz, Elisabete M S Castanheira, Paulo J G Coutinho
Iron oxide nanoparticles, with diameters around 12nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior with a coercive field of 9.7Oe and a blocking temperature of 118K. Both aqueous and solid magnetoliposomes containing magnetite nanoparticles have sizes below 150nm, suitable for biomedical applications. Interaction between both types of magnetoliposomes and models of biological membranes was proven. A new antitumor compound, a diarylurea derivative of thienopyridine, active against breast cancer, was incorporated in both aqueous and solid magnetoliposomes, being mainly located in the lipid membrane...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28730477/utilizing-the-luminex-magnetic-bead-based-suspension-array-for-rapid-multiplexed-phosphoprotein-quantification
#19
Adam Stewart, Udai Banerji
The study of protein phosphorylation is critical for the advancement of our understanding of cellular responses to external and internal stimuli. Phosphorylation, the addition of phosphate groups, most often occurs on serine, threonine, or tyrosine residues due to the action of protein kinases. This structural change causes the protein to become activated (or deactivated) and enables it in turn to initiate the phosphorylation of other proteins in a cascade, eventually causing cell-wide changes such as apoptosis, cell differentiation, and growth (among others)...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28727561/a-cots-based-microwave-imaging-system-for-breast-cancer-detection
#20
Mario R Casu, Marco Vacca, Jorge A Tobon, Azzurra Pulimeno, Imran Sarwar, Raffaele Solimene, Francesca Vipiana
Microwave imaging is an emerging breast cancer diagnostic technique, which aims at complementing already established methods like mammography, magnetic resonance imaging, and ultrasound. It offers two striking advantages: no-risk for the patient and potential low-cost for national health systems. So far, however, the prototypes developed for validation in labs and clinics used costly lab instruments such as a vector network analyzer (VNA). Moreover, the CPU time required by complex image reconstruction algorithms may not be compatible with the duration of a medical examination...
August 2017: IEEE Transactions on Biomedical Circuits and Systems
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