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https://www.readbyqxmd.com/read/29326994/single-coating-of-zinc-ferrite-renders-magnetic-nanomotors-therapeutic-and-stable-against-agglomeration
#1
Pooyath Lekshmy Venugopalan, Shilpee Jain, Srinivasrao Shivashankar, Ambarish Ghosh
Magnetic nanomotors with integrated theranostic capabilities can revolutionize biomedicine of the future. Typically, these nanomotors contain ferromagnetic materials, such that small magnetic fields can be used to maneuver and localize them in fluidic or gel-like environments. Motors with large permanent magnetic moments tend to agglomerate, which limits the scalability of this otherwise promising technology. Here, we demonstrate the application of a microwave-synthesized ferrite layer to reduce the agglomeration of helical ferromagnetic nanomotors by an order of magnitude, which allows them to be stored in a colloidal suspension for longer than six months and subsequently be manoeuvred with undiminished performance...
January 12, 2018: Nanoscale
https://www.readbyqxmd.com/read/29317074/the-concept-of-ferrofluid-preheating-in-the-treatment-of-cancer-by-magnetic-hyperthermia-of-tissues
#2
I Malaescu, P C Fannin, C N Marin, D Lazic
The frequency dependence of the complex magnetic susceptibility, χ(ω) = χ'(ω) - i χ″(ω), of a water-based magnetic fluid with magnetite particles, over the frequency range 500 kHz to 2 MHz and at three different temperatures of 30 °C, 40 °C and 50 °C are presented. Based on these experimental measurements, the dependence on frequency, f = (ω/2π) Hz, of the heating rate, ΔT/Δt, of the ferrofluid has been evaluated at these stated temperatures and alternating magnetic field of different amplitudes, Ho = 200 A/m, 400 A/m, 600 A/m, 800 A/m and 1 kA/m...
January 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29304105/dosimetric-evaluation-of-magnetic-resonance-generated-synthetic-ct-for-radiation-treatment-of-rectal-cancer
#3
Hesheng Wang, Kevin Du, Juliet Qu, Hersh Chandarana, Indra J Das
PURPOSE: The purpose of this study was to assess the dosimetric equivalence of magnetic resonance (MR)-generated synthetic CT (synCT) and simulation CT for treatment planning in radiotherapy of rectal cancer. METHODS: This study was conducted on eleven patients who underwent whole-body PET/MR and PET/CT examination in a prospective IRB-approved study. For each patient synCT was generated from Dixon MR using a model-based method. Standard treatment planning directives were used to create a four-field box (4F), an oblique four-field (O4F) and a volumetric modulated arc therapy (VMAT) plan on synCT for treatment of rectal cancer...
2018: PloS One
https://www.readbyqxmd.com/read/29299933/is-there-any-relationship-between-adc-values-of-diffusion-weighted-imaging-and-the-histopathologic-prognostic-factors-of-invasive-ductal-carcinoma
#4
Hale Aydin, Bahar Guner, Isil Esen Bostanci, Melda Boyacioglu Bulut, Bilgin Kadri Aribas, Lutfi Dogan, Mehmet Ali Gulcelik
OBJECTIVE: Magnetic resonance imaging (MRI) is being used increasingly as a modality than can provide important information about breast cancer. Diffusion weighted imaging (DWI) is an imaging technique from which ADC values can be calculated in addition to obtaining important structural information which cannot be obtained from other imaging studies. We did not find any significant relationships between ADC values and prognostic factors, but did provide some explanations for conflicting results in the literature...
January 4, 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29297526/nanoreactors-based-on-dnazyme-functionalized-magnetic-nanoparticles-activated-by-magnetic-field
#5
Saira F Bakshi, Nataliia Guz, Andrey Zakharchenko, Han Deng, Alexei V Tumanov, Craig D Woodworth, Sergiy Minko, Dmitry M Kolpashchikov, Evgeny Katz
A new biomimetic nanoreactor design, MaBiDz, is presented based on a copolymer brush in combination with superparamagnetic nanoparticles. This cellular nanoreactor features two species of magnetic particles, each functionalized with two components of a binary deoxyribozyme system. In the presence of a target mRNA analyte and a magnetic field, the nanoreactor is assembled to form a biocompartment enclosed by the polymeric brush that enables catalytic function of the binary deoxyribozyme with enhanced kinetics...
January 3, 2018: Nanoscale
https://www.readbyqxmd.com/read/29297241/exosomal-small-rna-sequencing-uncovers-the-microrna-dose-markers-for-power-frequency-electromagnetic-field-exposure
#6
Hualiang Li, Lin Lin, Li Li, Liang Zhou, Ying Zhang, Shuai Hao, Zhenhua Ding
PURPOSE: The potential health risks caused by power frequency electromagnetic field (PFEMF) have led to increasing public health concerns. However, the diagnosis and prognosis remain challenging in determination of exact dose of PFEMF exposure. MATERIALS AND METHODS: Mice were exposed to different magnetic doses of PFEMF for the following isolation of serum exosomes, microRNAs (miRNAs) extraction and small RNA sequencing. After small RNA sequencing, bioinformatic analysis and qRT-PCR validation, serum exosomal miRNA biomarkers were determined...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29291164/nanotheranostics-emerging-strategies-for-early-diagnosis-and-therapy-of-brain-cancer
#7
REVIEW
Sonali, Matte Kasi Viswanadh, Rahul Pratap Singh, Poornima Agrawal, Abhishesh Kumar Mehata, Datta Maroti Pawde, Narendra, Roshan Sonkar, Madaswamy Sona Muthu
Nanotheranostics have demonstrated the development of advanced platforms that can diagnose brain cancer at early stages, initiate first-line therapy, monitor it, and if needed, rapidly start subsequent treatments. In brain nanotheranostics, therapeutic as well as diagnostic entities are loaded in a single nanoplatform, which can be further developed as a clinical formulation for targeting various modes of brain cancer. In the present review, we concerned about theranostic nanosystems established till now in the research field...
2018: Nanotheranostics
https://www.readbyqxmd.com/read/29290280/nanomedicine-an-emerging-therapeutic-strategy-for-oral-cancer-therapy
#8
REVIEW
Sabrina Marcazzan, Elena Maria Varoni, Elvin Blanco, Giovanni Lodi, Mauro Ferrari
Oral cavity and oropharyngeal carcinomas (oral cancer) represents a significant cause of morbidity and mortality. Despite efforts in improving early diagnosis and treatment, the 5-year survival rate of advanced stage of the disease is less than 63%. The field of nanomedicine has offered promising diagnostic and therapeutic advances in cancer. Indeed, several platforms have been clinically approved for cancer therapy, while other promising systems are undergoing exploration in clinical trials. With its ability to deliver drugs, nucleic acids, and MRI contrast agents with high efficiency, nanomedicine platforms offer the potential to improve drug efficacy and tolerability...
January 2018: Oral Oncology
https://www.readbyqxmd.com/read/29289736/systematic-magnetic-fluid-hyperthermia-studies-of-carboxyl-functionalized-hydrophilic-superparamagnetic-iron-oxide-nanoparticles-based-ferrofluids
#9
Ganeshlenin Kandasamy, Atul Sudame, Piyush Bhati, Anindita Chakrabarty, S N Kale, Dipak Maity
We have systematically studied heating efficiencies (via specific absorption rate-SAR/intrinsic loss power-ILP) of carboxyl (terephthalic acid-TA) functionalized hydrophilic SPIONs based ferrofluids (with good biocompatibility/high magnetization) and influence of following key factors in magnetic fluid hyperthermia (MFH): (i) alternating magnetic fields (AMFs - H)/frequencies (f) - chosen below/above Hergt's biological safety limit, (ii) concentrations (0.5-8 mg/ml) and (iii) dispersion media (water, a cell-culture medium and triethylene glycol (TEG)) for in vitro cancer therapy...
December 24, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29285401/multifunctional-stimuli-responsive-polymer-gated-iron-and-gold-embedded-silica-nano-golf-balls-nanoshuttles-for-targeted-on-demand-theranostics
#10
Liping Wang, Grace Jang, Deependra Kumar Ban, Vrinda Sant, Jay Seth, Sami Kazmi, Nirav Patel, Qingqing Yang, Joon Lee, Woraphong Janetanakit, Shanshan Wang, Brian P Head, Gennadi Glinsky, Ratneshwar Lal
Multi-functional nanoshuttles for remotely targeted and on-demand delivery of therapeutic molecules and imaging to defined tissues and organs hold great potentials in personalized medicine, including precise early diagnosis, efficient prevention and therapy without toxicity. Yet, in spite of 25 years of research, there are still no such shuttles available. To this end, we have designed magnetic and gold nanoparticles (NP)-embedded silica nanoshuttles (MGNSs) with nanopores on their surface. Fluorescently labeled Doxorubicin (DOX), a cancer drug, was loaded in the MGNSs as a payload...
2017: Bone Research
https://www.readbyqxmd.com/read/29281265/responsive-nanomicellar-theranostic-cages-for-metastatic-breast-cancer
#11
Amrutha Manigandan, Vandhana Handi, Niranjana Sri Sundaramoorthy, Ramya Dhandapani, Janani Radhakrishnan, Swaminathan Sethuraman, Anuradha Subramanian
Precluding the progression of metastasis with early-diagnosis of triple-negative breast cancer remains challenging due to lack of targeting specificity with poor diagnostic potential. Herein, an amphipathic chitosan-based targeted nanomicellar theranostics (30-45 nm) comprising doxorubicin-superparamagnetic iron oxide nanoparticles complexes (89.23%) with lower critical micelle concentration (0.1 µg/mL) were developed. Micelles exhibits concentration-based contrast enhancement in MRI (r2 6.27mM-1s-1) and hyperthermia rather than thermal-ablation...
December 27, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29280466/image-distortions-on-a-plastic-interstitial-computed-tomography-magnetic-resonance-brachytherapy-applicator-at-3%C3%A2-tesla-magnetic-resonance-imaging-and-their-dosimetric-impact
#12
Laura E van Heerden, Zdenko van Kesteren, Oliver J Gurney-Champion, Antonetta C Houweling, Kees Koedooder, Coen R N Rasch, Bradley R Pieters, Arjan Bel
PURPOSE: To quantify magnetic resonance imaging (MRI) distortions on a plastic intracavitary/interstitial applicator with plastic needles at a field strength of 3 T and to determine the dosimetric impact, using patient data. METHODS AND MATERIALS: For 11 cervical cancer patients, our clinical MRI protocol was extended with 3 scans. From the first scan, a multi-echo acquisition, a map of the magnetic field (B0) was calculated and used to quantify the field inhomogeneity...
November 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29231948/a-tailored-nanosheet-decorated-with-a-metallized-dendrimer-for-angiography-and-magnetic-resonance-imaging-guided-combined-chemotherapy
#13
Guilong Zhang, Ruohong Du, Junchao Qian, Xiaojia Zheng, Xiaohe Tian, Dongqing Cai, Jiacai He, Yiqun Wu, Wei Huang, Yuanyin Wang, Xin Zhang, Kai Zhong, Duohong Zou, Zhengyan Wu
Considering the chemical exchange between gadolinium centers and water protons, nanosystems comprising gadolinium conjugated with high specific area nanocarriers might serve as more robust clinical tools for diagnosis and imaging-guided therapy. Herein, a pH-responsive nanosystem containing graphene oxide conjugated with a folic acid- and gadolinium-labeled dendrimer (FA-GCGLD) to boost its T1 contrast ability was developed, and doxorubicin (DOX) and colchicine (COLC) were efficiently loaded onto this nanosystem (FA-GCGLD-DOX/COLC)...
December 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/29229326/quantifying-the-effect-of-3t-magnetic-resonance-imaging-residual-system-distortions-and-patient-induced-susceptibility-distortions-on-radiation-therapy-treatment-planning-for-prostate-cancer
#14
Mary Adjeiwaah, Mikael Bylund, Josef A Lundman, Camilla Thellenberg Karlsson, Joakim H Jonsson, Tufve Nyholm
PURPOSE: To investigate the effect of magnetic resonance system- and patient-induced susceptibility distortions from a 3T scanner on dose distributions for prostate cancers. METHODS AND MATERIALS: Combined displacement fields from the residual system and patient-induced susceptibility distortions were used to distort 17 prostate patient CT images. VMAT dose plans were initially optimized on distorted CT images and the plan parameters transferred to the original patient CT images to calculate a new dose distribution...
October 20, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29229179/clinical-role-of-breast-mri-now-and-going-forward
#15
REVIEW
D Leithner, G J Wengert, T H Helbich, S Thakur, R E Ochoa-Albiztegui, E A Morris, K Pinker
Magnetic resonance imaging (MRI) is a well-established method in breast imaging, with manifold clinical applications, including the non-invasive differentiation between benign and malignant breast lesions, preoperative staging, detection of scar versus recurrence, implant assessment, and the evaluation of high-risk patients. At present, dynamic contrast-enhanced MRI is the most sensitive imaging technique for breast cancer diagnosis, and provides excellent morphological and to some extent also functional information...
December 8, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/29225557/toward-the-development-of-a-flexible-mesoscale-mri-compatible-neurosurgical-continuum-robot
#16
Yeongjin Kim, Shing Shin Cheng, Mahamadou Diakite, Rao P Gullapalli, J Marc Simard, Jaydev P Desai
Brain tumor, be it primary or metastatic, is usually life threatening for a person of any age. Primary surgical resection which is one of the most effective ways of treating brain tumors can have tremendously increased success rate if the appropriate imaging modality is used for complete tumor resection. Magnetic resonance imaging (MRI) is the imaging modality of choice for brain tumor imaging because of its excellent soft-tissue contrast. MRI combined with continuum soft robotics has immense potential to be the next major technological breakthrough in the field of brain cancer diagnosis and therapy...
December 2017: IEEE Transactions on Robotics: a Publication of the IEEE Robotics and Automation Society
https://www.readbyqxmd.com/read/29218857/the-combined-effect-of-thermal-and-chemotherapy-on-hela-cells-using-magnetically-actuated-smart-textured-fibrous-system
#17
Pranav Tiwari, Sakshi Agarwal, Sachchidanand Srivastava, Shilpee Jain
Thermal therapy combined with chemotherapy is one of the advanced and efficient methods to eradicate cancer. In this work, we fabricated magnetically actuated smart textured (MAST) fibrous systems and studied their candidacy for cancer treatment. The polycaprolactone-Fe3 O4 based MAST fibers were fabricated using electrospinning technique. These MAST fibrous systems contained carbogenic quantum dots as a tracking agent and doxorubicin hydrochloride anticancer drug. Additionally, as fabricated MAST fibrous systems were able to deliver anticancer drug and heat energy simultaneously to kill HeLa cells in a 10 min period in vitro...
January 2018: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/29218271/magnetic-resonance-imaging-in-precision-radiation-therapy-for-lung-cancer
#18
REVIEW
Hannah Bainbridge, Ahmed Salem, Rob H N Tijssen, Michael Dubec, Andreas Wetscherek, Corinne Van Es, Jose Belderbos, Corinne Faivre-Finn, Fiona McDonald
Radiotherapy remains the cornerstone of curative treatment for inoperable locally advanced lung cancer, given concomitantly with platinum-based chemotherapy. With poor overall survival, research efforts continue to explore whether integration of advanced radiation techniques will assist safe treatment intensification with the potential for improving outcomes. One advance is the integration of magnetic resonance imaging (MRI) in the treatment pathway, providing anatomical and functional information with excellent soft tissue contrast without exposure of the patient to radiation...
December 2017: Translational Lung Cancer Research
https://www.readbyqxmd.com/read/29215164/magnetically-guided-self-assembly-and-coding-of-3d-living-architectures
#19
Alessandro Tocchio, Naside Gozde Durmus, Kaushik Sridhar, Vigneshwaran Mani, Bukre Coskun, Rami El Assal, Utkan Demirci
In nature, cells self-assemble at the microscale into complex functional configurations. This mechanism is increasingly exploited to assemble biofidelic biological systems in vitro. However, precise coding of 3D multicellular living materials is challenging due to their architectural complexity and spatiotemporal heterogeneity. Therefore, there is an unmet need for an effective assembly method with deterministic control on the biomanufacturing of functional living systems, which can be used to model physiological and pathological behavior...
December 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29212734/predictors-of-response-and-survival-in-locally-advanced-adenocarcinoma-of-the-pancreas-following-neoadjuvant-gtx-with-or-without-radiation-therapy
#20
William H Sherman, Elizabeth Hecht, David Leung, Kyung Chu
LESSONS LEARNED: There is no presenting parameter that predicts the success of neoadjuvant therapy for pancreatic cancer.Despite the images on scans following neoadjuvant therapy, all patients should be evaluated, because inflammation following radiation therapy (RT) may overstate the extent of tumor and vascular involvement. BACKGROUND: In patients presenting with locally advanced pancreatic adenocarcinoma deemed unresectable by two pancreatic cancer surgeons, we analyzed presenting tumor size, extent of vascular involvement, tumor markers, response to neoadjuvant gemcitabine (G), docetaxel (T), and capecitabine (X) with or without additional chemoradiotherapy with GX on R0 resection rates (≥2 mm margins), and survival...
December 6, 2017: Oncologist
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