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https://www.readbyqxmd.com/read/29784058/fat-suppressed-gadolinium-enhanced-isotropic-high-resolution-3d-gre-t1wi-for-predicting-small-node-metastases-in-patients-with-rectal-cancer
#1
Yan Chen, Xinyue Yang, Ziqiang Wen, Baolan Lu, Xiaojuan Xiao, Bingqi Shen, Shenping Yu
BACKGROUND: To investigate the application value of fat-suppressed gadolinium-enhanced isotropic high-resolution 3D-GRE-T1WI in regional nodes with different short-axis diameter ranges in rectal cancer, especially in nodes ≤5 mm. METHODS: Patients with rectal adenocarcinoma confirmed by postoperative histopathology were included, and all the patients underwent preoperative 3.0 T rectal magnetic resonance imaging (MRI) and total mesorectal excision (TME) within 2 weeks after an MR scan...
May 21, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29781852/the-effect-of-postmastectomy-radiation-therapy-on-breast-implants-material-analysis-on-silicone-and-polyurethane-prosthesis
#2
Federico Lo Torto, Michela Relucenti, Giuseppe Familiari, Nicola Vaia, Donato Casella, Roberto Matassa, Selenia Miglietta, Franco Marinozzi, Fabiano Bini, Ilaria Fratoddi, Fabio Sciubba, Raffaele Cassese, Vincenzo Tombolini, Diego Ribuffo
INTRODUCTION: The pathogenic mechanism underlying capsular contracture is still unknown. It is certainly a multifactorial process, resulting from human body reaction, biofilm activation, bacteremic seeding, or silicone exposure. The scope of the present article is to investigate the effect of hypofractionated radiotherapy protocol (2.66 Gy × 16 sessions) both on silicone and polyurethane breast implants. METHODS: Silicone implants and polyurethane underwent irradiation according to a hypofractionated radiotherapy protocol for the treatment of breast cancer...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29769042/mpcad-a-multi-scale-radiomics-driven-framework-for-automated-prostate-cancer-localization-and-detection
#3
Farzad Khalvati, Junjie Zhang, Audrey G Chung, Mohammad Javad Shafiee, Alexander Wong, Masoom A Haider
BACKGROUND: Quantitative radiomic features provide a plethora of minable data extracted from multi-parametric magnetic resonance imaging (MP-MRI) which can be used for accurate detection and localization of prostate cancer. While most cancer detection algorithms utilize either voxel-based or region-based feature models, the complexity of prostate tumour phenotype in MP-MRI requires a more sophisticated framework to better leverage available data and exploit a priori knowledge in the field...
May 16, 2018: BMC Medical Imaging
https://www.readbyqxmd.com/read/29763715/near-infrared-light-activated-red-emitting-upconverting-nanoplatform-for-t-1-weighted-magnetic-resonance-imaging-and-photodynamic-therapy
#4
Xiang-Long Tang, Jun Wu, Ben-Lan Lin, Sheng Cui, Hong-Mei Liu, Ru-Tong Yu, Xiao-Dong Shen, Ting-Wei Wang, Wei Xia
Photodynamic therapy (PDT) has increasingly become an efficient and attractive cancer treatment modality based on reactive oxygen species (ROS) that can induce tumor death after irradiation with ultraviolet or visible light. Herein, to overcome the limited tissue penetration in traditional PDT, a novel near-infrared (NIR) light-activated NaScF4 : 40% Yb, 2% Er@CaF2 upconversion nanoparticle (rUCNP) is successfully designed and synthesized. Chlorin e6, a photosensitizer and a chelating agent for Mn2+ , is loaded into human serum albumin (HSA) that further conjugates onto rUCNPs...
May 12, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29761065/pulsed-magnetic-resonance-to-signal-enhance-metabolites-within-seconds-by-utilizing-para-hydrogen
#5
Sergey Korchak, Shengjun Yang, Salvatore Mamone, Stefan Glöggler
Diseases such as Alzheimer's and cancer have been linked to metabolic dysfunctions, and further understanding of metabolic pathways raises hope to develop cures for such diseases. To broaden the knowledge of metabolisms in vitro and in vivo, methods are desirable for direct probing of metabolic function. Here, we are introducing a pulsed nuclear magnetic resonance (NMR) approach to generate hyperpolarized metabolites within seconds, which act as metabolism probes. Hyperpolarization represents a magnetic resonance technique to enhance signals by over 10 000-fold...
May 2018: ChemistryOpen
https://www.readbyqxmd.com/read/29757721/spectrum-of-extratesticular-and-testicular-pathologic-conditions-at-scrotal-mr-imaging
#6
Pardeep K Mittal, Ahmed S Abdalla, Argha Chatterjee, Deborah A Baumgarten, Peter A Harri, Jay Patel, Courtney C Moreno, Helena Gabriel, Frank H Miller
Diagnostic workup of scrotal lesions should begin with a complete clinical history and physical examination, including analysis of risk factors such as family history of testicular cancer, personal history of tumor in the contralateral testis, and cryptorchidism, followed by imaging. Scrotal ultrasonography (US) with a combination of gray-scale and color Doppler techniques has been the first-line imaging modality for evaluation of testicular and extratesticular lesions because of its low cost, wide availability, and high diagnostic accuracy...
May 2018: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/29748550/novel-method-for-rapid-toxicity-screening-of-magnetic-nanoparticles
#7
A Erofeev, P Gorelkin, A Garanina, A Alova, M Efremova, N Vorobyeva, C Edwards, Y Korchev, A Majouga
Iron oxide nanoparticles have attracted a great deal of research interest and have been widely used in bioscience and clinical research including as contrast agents for magnetic resonance imaging, hyperthermia and magnetic field assisted radionuclide therapy. It is therefore important to develop methods, which can provide high-throughput screening of biological responses that can predict toxicity. The use of nanoelectrodes for single cell analysis can play a vital role in this process by providing relatively fast, comprehensive, and cost-effective assessment of cellular responses...
May 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29748046/the-visibility-of-the-terminal-thoracic-duct-into-the-venous-system-using-mr-thoracic-ductography-with-balanced-turbo-field-echo-sequence
#8
Takakiyo Nomura, Tetsu Niwa, Soji Ozawa, Junya Oguma, Shuhei Shibukawa, Yutaka Imai
RATIONALE AND OBJECTIVES: Magnetic resonance thoracic ductography (MRTD) with balanced turbo field echo (bTFE) can visualize both the thoracic duct and its surrounding vessels. This study aimed to investigate the visibility of the terminal thoracic duct into the venous system in the subclavian region using MRTD with bTFE. MATERIALS AND METHODS: MRTD was performed with bTFE as a preoperative workup comprising respiratory gating on a 1.5-T magnetic resonance system for patients with esophageal cancer...
May 7, 2018: Academic Radiology
https://www.readbyqxmd.com/read/29745036/non-small-cell-lung-cancer-brain-metastasis-screening-in-the-era-of-positron-emission-tomography-ct-staging-current-practice-and-outcomes
#9
Mauricio E Diaz, Maciej Debowski, Craig Hukins, David Fielding, Kwun M Fong, Catherine S Bettington
INTRODUCTION: Several clinical guidelines indicate that brain metastasis screening (BMS) should be guided by disease stage in non-small cell lung cancer (NSCLC). We estimate that screening is performed more broadly in practice, and patients undergo brain imaging at considerable cost with questionable benefit. Our aim was to quantify the use and detection rate of BMS in a contemporary cohort staged with 18 F-fluorodeoxyglucose positron emission tomography/computed tomography (PET-CT). METHODS: We conducted a retrospective review of prospectively collected data from three major lung cancer referral centres in Brisbane between January 2011 and December 2015...
May 10, 2018: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/29741977/laparoscopic-pelvic-exenteration-for-locally-advanced-rectal-cancer-technique-and-short-term-outcomes
#10
Ashish Pokharkar, Praveen Kammar, Ashwin D'souza, Rahul Bhamre, Pavan Sugoor, Avanish Saklani
BACKGROUND: Since last two decades minimally invasive techniques have revolutionized surgical field. In 2003 Pomel first described laparoscopic pelvic exenteration, since then very few reports have described minimally invasive approaches for total pelvic exenteration. METHODS: We report the 10 cases of locally advanced rectal adenocarcinoma which were operated between the periods from March 1, 2017 to November 11, 2017 at the Tata Memorial Hospital, Mumbai. All male patients had lower rectal cancer with prostate involvement on magnetic resonance imaging (MRI)...
May 9, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29736266/interplay-of-cell-death-signaling-pathways-mediated-by-alternating-magnetic-field-gradient
#11
De Wei Wong, Wei Liang Gan, Yuan Kai Teo, Wen Siang Lew
The ability to control or manipulate the pathways leading to cell death plays a pivotal role in cancer treatment. We demonstrate magneto-actuation of magnetic nanoparticles (MNPs) to induce different cell death signaling pathways, exemplifying the intricate interplay between apoptosis and necrosis. In vitro cell experiments show the cell viabilities decreases with increasing field strength and is lower in cells treated with low aspect ratio MNPs. In a strong vertical magnetic field gradient, the MNPs were able to apply sufficient force on the cell to trigger the intracellular pathway for cell apoptosis, thus significantly reducing the cell viability...
2018: Cell Death Discovery
https://www.readbyqxmd.com/read/29733199/nanosystems-based-on-magnetic-nanoparticles-and-thermo-or-ph-responsive-polymers-an-update-and-future-perspectives
#12
Binh T Mai, Soraia Fernandes, Preethi B Balakrishnan, Teresa Pellegrino
Combining hard matter, like inorganic nanocrystals, and soft materials, like polymers, can generate multipurpose materials with a broader range of applications with respect to the individual building blocks. Given their unique properties at the nanoscale, magnetic nanoparticles (MNPs) have drawn a great deal of interest due to their potential use in the biomedical field, targeting several applications such as heat hubs in magnetic hyperthermia (MHT, a heat-damage based therapy), contrast agents in magnetic resonance imaging (MRI), and nanocarriers for targeted drug delivery...
May 7, 2018: Accounts of Chemical Research
https://www.readbyqxmd.com/read/29732002/implantable-wireless-powered-light-emitting-diode-led-for-near-infrared-photoimmunotherapy-device-development-and-experimental-assessment-in-vitro-and-in-vivo
#13
Kohei Nakajima, Toshihiro Kimura, Hideo Takakura, Yasuo Yoshikawa, Atsushi Kameda, Takayuki Shindo, Kazuhide Sato, Hisataka Kobayashi, Mikako Ogawa
Purpose: The aim of this study was to develop and assess a novel implantable, wireless-powered, light-emitting diode (LED) for near-infrared photoimmunotherapy (NIR-PIT). NIR-PIT is a recently developed cancer therapy that uses NIR light and antibody-photosensitizer conjugates and is able to induce cancer-specific cell death. Due to limited light penetration depth it is currently unable to treat tumors in deep tissues. Use of implanted LED might potentially overcome this limitation. Results: The wireless LED system was able to emit NIR light up to a distance of 20 cm from the transmitter coil by using low magnetic fields as compliant with limits for use in humans...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29729897/injectable-magnetic-supramolecular-hydrogel-with-magnetocaloric-liquid-conformal-property-prevents-the-post-operative-recurrence-in-a-breast-cancer-model
#14
Haoan Wu, Lina Song, Ling Chen, Wei Zhang, Yi Chen, Fengchao Zang, Hong Chen, Ming Ma, Ning Gu, Yu Zhang
Locoregional recurrence of breast cancer after tumor resection represents several clinical challenges. Here, we demonstrate that co-delivery of chemotherapy and thermotherapeutic agents by a magnetic supramolecular hydrogel (MSH) following tumor resection prevents tumor recurrence in a breast cancer mouse model. The self-assembled MSH was designed through the partial inclusion complexation associated with the threading of α-CD on the copolymer moieties on the surface of the PEGylated iron oxide (Fe3 O4 ) nanoparticles, which enables shear-thinning injection and controllable thermoreversible gel-sol transition...
May 3, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29726358/how-advances-in-imaging-will-affect-precision-radiation-oncology
#15
David A Jaffray, Shiva Das, Paula M Jacobs, Robert Jeraj, Philippe Lambin
Radiation oncology is 1 of the most structured disciplines in medicine. It is of a highly technical nature with reliance on robotic systems to deliver intervention, engagement of diverse expertise, and early adoption of digital approaches to optimize and execute the application of this highly effective cancer treatment. As a localized intervention, the dependence on sensitive, specific, and accurate imaging to define the extent of disease, its heterogeneity, and adjacency to normal tissues directly affects the therapeutic ratio...
June 1, 2018: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/29726296/folate-molecular-encapsulator-tethered-biocompatible-polymer-grafted-with-magnetic-nanoparticles-for-augmented-drug-delivery
#16
Sivaraj Ramasamy, Rex Jeya Rajkumar Sam David, Israel V M V Enoch
Magnetic ferrite nanoparticles (MNPs) coated with biocompatible polymers capable of drug loading and release are fascinating nanostructures for delivering anti-cancer drugs. Herein, we report the synthesis and characterization of a novel β-cyclodextrin-folate-tethered dextran polymer. Nickel-zinc ferrite nanoparticles are prepared and coated with the polymer to form a biocompatible hybrid magnetic nanocarrier. To establish the significance of folate unit of the polymer in anticancer activity, a similar derivatized polymer, i...
May 4, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29723846/diagnostic-value-of-nineteen-different-imaging-methods-for-patients-with-breast-cancer-a-network-meta-analysis
#17
Xiao-Hong Zhang, Can Xiao
BACKGROUND/AIMS: We performed a network meta-analysis (NMA) to investigate and compare the diagnostic value of 19 different imaging methods used for breast cancer (BC). METHODS: Cochrane Library, PubMed and EMBASE were searched to collect the relevant literature from the inception of the study until November 2016. A combination of direct and indirect comparisons was performed using an NMA to evaluate the combined odd ratios (OR) and draw the surface under the cumulative ranking curves (SUCRA) of the diagnostic value of different imaging methods for BC...
April 28, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29723626/doxorubicin-hydrochloride-loaded-electrospun-chitosan-cobalt-ferrite-titanium-oxide-nanofibers-for-hyperthermic-tumor-cell-treatment-and-controlled-drug-release
#18
Maryam Radmansouri, Ehsan Bahmani, Einollah Sarikhani, Keivan Rahmani, Fariborz Sharifianjazi, Mohammad Irani
In the present study, the potential of doxorubicin hydrochloride (DOX)-loaded electrospun chitosan/cobalt ferrite/titanium oxide nanofibers was studied to investigate the simultaneous effect of hyperthermia and chemotherapy against melanoma cancer B16F10 cell lines. The cobalt ferrite nanoparticles were synthesized via microwave heating method. The titanium oxide nanoparticles were mixed with cobalt ferrite to control the temperature rise. The synthesized nanoparticles and nanofibers were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), and vibrating sample magnetometer (VSM) analysis...
April 30, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29721598/current-utilization-and-procedural-practices-in-pediatric-whole-body-mri
#19
Gary R Schooler, Joseph T Davis, Heike E Daldrup-Link, Donald P Frush
BACKGROUND: Whole-body magnetic resonance imaging (MRI) is an evolving and increasingly powerful imaging tool with a variety of applications in the pediatric patient population. Variability exists among radiology practices in how this MRI tool is used and how it performed. OBJECTIVE: Our objective was to gain an improved understanding of technical and utilization practices in pediatric whole-body MRI across North America by exploring indications for exam performance, determining referral patterns, and assessing technical protocols and procedures...
May 2, 2018: Pediatric Radiology
https://www.readbyqxmd.com/read/29715088/application-of-albumin-embedded-magnetic-nanoheaters-for-release-of-etoposide-in-integrated-chemotherapy-and-hyperthermia-of-u87-mg-glioma-cells
#20
Melánia Babincová, Hana Vrbovská, Paul Sourivong, Peter Babinec, Štefan Durdík
BACKGROUND/AIM: Malignant gliomas remain refractory to several therapeutic approaches and the requirement for novel treatment modalities is critical to combat this disease. Etoposide is a topoisomerase-II inhibitor, which promotes DNA damage and apoptosis of cancer cells. In this study, we prepared albumin with embedded magnetic nanoparticles and etoposide for in vitro evaluation of combined hyperthermia and chemotherapy. MATERIAL AND METHODS: Magnetic nanoparticles were prepared by a modified co-precipitation method in the presence of human serum albumin and etoposide...
May 2018: Anticancer Research
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