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https://www.readbyqxmd.com/read/28338285/remote-control-of-cellular-functions-the-role-of-smart-nanomaterials-in-the-medicine-of-the-future
#1
REVIEW
Giada Graziana Genchi, Attilio Marino, Agostina Grillone, Ilaria Pezzini, Gianni Ciofani
The remote control of cellular functions through smart nanomaterials represents a biomanipulation approach with unprecedented potential applications in many fields of medicine, ranging from cancer therapy to tissue engineering. By actively responding to external stimuli, smart nanomaterials act as real nanotransducers able to mediate and/or convert different forms of energy into both physical and chemical cues, fostering specific cell behaviors. This report describes those classes of nanomaterials that have mostly paved the way to a "wireless" control of biological phenomena, focusing the discussion on some examples close to the clinical practice...
March 24, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28335790/physical-mechanism-and-modeling-of-heat-generation-and-transfer-in-magnetic-fluid-hyperthermia-through-n%C3%A3-elian-and-brownian-relaxation-a-review
#2
REVIEW
Suriyanto, E Y K Ng, S D Kumar
Current clinically accepted technologies for cancer treatment still have limitations which lead to the exploration of new therapeutic methods. Since the past few decades, the hyperthermia treatment has attracted the attention of investigators owing to its strong biological rationales in applying hyperthermia as a cancer treatment modality. Advancement of nanotechnology offers a potential new heating method for hyperthermia by using nanoparticles which is termed as magnetic fluid hyperthermia (MFH). In MFH, superparamagnetic nanoparticles dissipate heat through Néelian and Brownian relaxation in the presence of an alternating magnetic field...
March 23, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28335204/multifunctional-inorganic-nanoparticles-recent-progress-in-thermal-therapy-and-imaging
#3
REVIEW
Kondareddy Cherukula, Kamali Manickavasagam Lekshmi, Saji Uthaman, Kihyun Cho, Chong-Su Cho, In-Kyu Park
Nanotechnology has enabled the development of many alternative anti-cancer approaches, such as thermal therapies, which cause minimal damage to healthy cells. Current challenges in cancer treatment are the identification of the diseased area and its efficient treatment without generating many side effects. Image-guided therapies can be a useful tool to diagnose and treat the diseased tissue and they offer therapy and imaging using a single nanostructure. The present review mainly focuses on recent advances in the field of thermal therapy and imaging integrated with multifunctional inorganic nanoparticles...
April 18, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28316873/nonholonomic-closed-loop-velocity-control-of-a-soft-tethered-magnetic-capsule-endoscope
#4
Addisu Z Taddese, Piotr R Slawinski, Keith L Obstein, Pietro Valdastri
In this paper, we demonstrate velocity-level closed-loop control of a tethered magnetic capsule endoscope that is actuated via serial manipulator with a permanent magnet at its end-effector. Closed-loop control (2 degrees-of-freedom in position, and 2 in orientation) is made possible with the use of a real-time magnetic localization algorithm that utilizes the actuating magnetic field and thus does not require additional hardware. Velocity control is implemented to create smooth motion that is clinically necessary for colorectal cancer diagnostics...
October 2016: Proceedings of the ... IEEE/RSJ International Conference on Intelligent Robots and Systems
https://www.readbyqxmd.com/read/28315379/magnetic-nanoparticles-for-efficient-cell-transduction-with-semliki-forest-virus
#5
Baiba Kurena, Aleksandra Vežāne, Dace Skrastiņa, Olga Trofimova, Anna Zajakina
Semliki Forest virus (SFV) is a potential cancer gene therapy vector capable of providing high and transient expression of heterologous proteins in mammalian cells. However, SFV has shown suboptimal transduction levels in several cancer cell types as well as wide biodistribution of SFV has been observed after in vivo applications. Magnetic nanoparticles (MNPs) have been shown to increase cell transduction with several viral vectors in vitro under an external magnetic field and enhance magnetically guided viral vector delivery...
March 14, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28306555/assessment-of-dosimetric-impact-of-system-specific-geometric-distortion-in-an-mri-only-based-radiotherapy-workflow-for-prostate
#6
C Gustafsson, F Nordström, E Persson, J Brynolfsson, L E Olsson
Dosimetric errors in a magnetic resonance imaging (MRI) only radiotherapy workflow may be caused by system specific geometric distortion from MRI. The aim of this study was to evaluate the impact on planned dose distribution and delineated structures for prostate patients, originating from this distortion. A method was developed, in which computer tomography (CT) images were distorted using the MRI distortion field. The displacement map for an optimized MRI treatment planning sequence was measured using a dedicated phantom in a 3 T MRI system...
March 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28306552/precise-determination-of-the-heat-delivery-during-in-vivo-magnetic-nanoparticle-hyperthermia-with-infrared-thermography
#7
Harley Rodrigues, Gustavo Capistrano, Francyelli Mello, Nicholas Zufelato, Elisangela Silveira-Lacerda, Andris F Bakuzis
Monitoring noninvasively and in real-time the heat delivery during magnetic nanoparticle hyperthermia is of fundamental importance to predict clinical outcome for cancer treatment. Infrared thermography (IRT) can inform the surface temperature due to three-dimensional heat delivery inside a subcutaneous tumor, an argument that is supported by numerical simulations. However, for precise temperature determination, it is of crucial relevance to use a correct experimental configuration. This work reports a magnetic nanoparticle hyperthermia study (MNH) using a sarcoma 180 murine tumor containing 3...
March 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28297882/quantum-mechanical-model-for-the-anticarcinogenic-effect-of-extremely-low-frequency-electromagnetic-fields-on-early-chemical-hepatocarcinogenesis
#8
Juan José Godina-Nava, Gabino Torres-Vega, Germán Octavio López-Riquelme, Eduardo López-Sandoval, Arturo Rodolfo Samana, Fermín García Velasco, Claudia Hernández-Aguilar, Arturo Domínguez-Pacheco
Using the conventional Haberkorn approach, it is evaluated the recombination of the radical pair (RP) singlet spin state to study theoretically the cytoprotective effect of an extremely-low-frequency electromagnetic field (ELF-EMF) on early stages of hepatic cancer chemically induced in rats. The proposal is that ELF-EMF modulates the interconversion rate of singlet and triplet spin states of the RP populations modifying the products from the metabolization of carcinogens. Previously, we found that the daily treatment with ELF-EMF 120 Hz inhibited the number and area of preneoplastic lesions in chemical carcinogenesis...
February 2017: Physical Review. E
https://www.readbyqxmd.com/read/28289406/antagonistic-activity-and-mode-of-action-of-phenazine-1-carboxylic-acid-produced-by-marine-bacterium-pseudomonas-aeruginosa-pa31x-against-vibrio-anguillarum-in-vitro-and-in-a-zebrafish-in-vivo-model
#9
Linlin Zhang, Xueying Tian, Shan Kuang, Ge Liu, Chengsheng Zhang, Chaomin Sun
Phenazine and its derivatives are very important secondary metabolites produced from Pseudomonas spp. and have exhibited broad-spectrum antifungal and antibacterial activities. However, till date, there are few reports about marine derived Pseudomonas and its production of phenazine metabolites. In this study, we isolated a marine Pseudomonas aeruginosa strain PA31x which produced natural product inhibiting the growth of Vibrio anguillarum C312, one of the most serious bacterial pathogens in marine aquaculture...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28277651/nanoengineering-of-core-shell-magnetic-mesoporous-microspheres-with-tunable-surface-roughness
#10
Qin Yue, Yu Zhang, Yongjian Jiang, Jialuo Li, Hongwei Zhang, Chengzhong Yu, Ahmed A Elzatahry, Abdulaziz Alghamdi, Yonghui Deng, Dongyuan Zhao
Functional core-shell mesoporous microspheres with integrated functions, controlled structure, and surface properties and morphologies have received increasing attention due to their excellent physicochemical properties. Herein, core-shell magnetic mesoporous materials with cauliflower-like morphology and tunable surface roughness have been synthesized through a kinetics-controlled interface co-assembly and deposition of mesostructured nanocomposites on Fe3O4@RF microspheres (RF refers to resorcinol formaldehyde resin)...
March 22, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28273899/in-vivo-microscopic-voxel-based-morphometry-with-a-brain-template-to-characterize-strain-specific-structures-in-the-mouse-brain
#11
Keigo Hikishima, Yuji Komaki, Fumiko Seki, Yasuyuki Ohnishi, Hirotaka J Okano, Hideyuki Okano
Hundreds of inbred mouse strains are established for use in a broad spectrum of basic research fields, including genetics, neuroscience, immunology, and cancer. Inbred mice exhibit identical intra-strain genetics and divergent inter-strain phenotypes. The cognitive and behavioral divergences must be controlled by the variances of structure and function of their brains; however, the underlying morphological features of strain-to-strain difference remain obscure. Here, in vivo microscopic magnetic resonance imaging was optimized to image the mouse brains by using an isotropic resolution of 80 μm...
December 2017: Scientific Reports
https://www.readbyqxmd.com/read/28270067/the-effects-of-nanoencapsulated-curcumin-fe3o4-on-proliferation-and-htert-gene-expression-in-lung-cancer-cells
#12
Hadi Sadeghzadeh, Younes Pilehvar-Soltanahmadi, Abolfazl Akbarzadeh, Hassan Dariushnejad, Forough Sanjarian, Nosratollah Zarghami
OBJECTIVE: The aim of the study is to fabricate curcumin-loaded PLGA-PEG-Fe3O4 nanoparticles and comprise the effects of pure curcumin and curcumin-nanomagnetic encapsulated in PLGA-PEG on cell cytotoxicity and hTERT gene expression in A549 lung cancer cell line. BACKGROUND: Lung cancer is the most common cancer in men and one of the four main cancers that occurs in women. Telomerase is active in more than 85% of various cancerous cells such as lung cancer while its activity is very low in normal cells...
February 13, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28269207/effects-of-extremely-low-frequency-electromagnetic-fields-on-in-vitro-cellular-cultures-hela-and-cho
#13
A F Restrepo, V E Tobar, R J Camargo, E Franco, C R Pinedo, O Gutierrez
This paper presents the cellular proliferation effects of the exposure to extremely low frequency electromagnetic fields (ELF-EMF) on in-vitro cellular cultures HeLa and CHO. Through the magnetic stimulation system (MSS) the cells were exposed to magnetic fields with sinusoidal waveform at 50 Hz; initially for 40 minutes at intensities of 0.4 mT, 1.4 mT, 2.13 mT, 2.49 mT and 2.53 mT in parallel and perpendicular directions to the culture plates. Subsequently, the repetitive electromagnetic field (rEMF) was applied to 2...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28266526/elf-mf-exposure-affects-the-robustness-of-epigenetic-programming-during-granulopoiesis
#14
Melissa Manser, Mohamad R Abdul Sater, Christoph D Schmid, Faiza Noreen, Manuel Murbach, Niels Kuster, David Schuermann, Primo Schär
Extremely-low-frequency magnetic fields (ELF-MF) have been classified as "possibly carcinogenic" to humans on the grounds of an epidemiological association of ELF-MF exposure with an increased risk of childhood leukaemia. Yet, underlying mechanisms have remained obscure. Genome instability seems an unlikely reason as the energy transmitted by ELF-MF is too low to damage DNA and induce cancer-promoting mutations. ELF-MF, however, may perturb the epigenetic code of genomes, which is well-known to be sensitive to environmental conditions and generally deranged in cancers, including leukaemia...
March 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28260891/superparamagnetic-reconstituted-high-density-lipoprotein-nanocarriers-for-magnetically-guided-drug-delivery
#15
Sarika Sabnis, Nirupama A Sabnis, Sangram Raut, Andras G Lacko
Current cancer chemotherapy is frequently associated with short- and long-term side effects, affecting the quality of life of cancer survivors. Because malignant cells are known to overexpress specific surface antigens, including receptors, targeted drug delivery is often utilized to reduce or overcome side effects. The current study involves a novel targeting approach using specifically designed nanoparticles, including encapsulation of the anti-cancer drug valrubicin into superparamagnetic iron oxide nanoparticle (SPION) containing reconstituted high-density lipoprotein (rHDL) nanoparticles...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28259837/shape-memory-polymers-with-enhanced-visibility-for-magnetic-resonance-and-x-ray-imaging-modalities
#16
A C Weems, J M Szafron, A D Easley, S Herting, J Smolen, D J Maitland
Currently, monitoring of minimally invasive medical devices is performed using fluoroscopy. The risks associated with fluoroscopy, including increased risk of cancer, make this method especially unsuitable for pediatric device delivery and follow-up procedures. A more suitable method is magnetic resonance (MR) imaging, which makes use of harmless magnetic fields rather than ionizing radiation when imaging the patient; this method is safer for both the patient and the performing technicians. Unfortunately, there is a lack of research available on bulk polymeric materials to enhance MR-visibility for use in medical devices...
March 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28256661/redox-responsive-dextran-based-theranostic-nanoparticles-for-near-infrared-magnetic-resonance-imaging-and-magnetically-targeted-photodynamic-therapy
#17
Zexuan Ding, Peng Liu, Dehong Hu, Zonghai Sheng, Huqiang Yi, Guanhui Gao, Yayun Wu, Pengfei Zhang, Shaozhi Ling, Lintao Cai
Photodynamic therapy (PDT) is a site-specific treatment of cancer using much lower optical power densities with minimal nonspecific damage to normal tissues. To improve the therapeutic efficiency of PDT, we fabricated a multifunctional theranostic nanoparticle system (DSSCe6@Fe3O4 NPs) by loading Fe3O4 nanoparticles in redox-responsive chlorin e6 (Ce6)-conjugated dextran nanoparticles for near-infrared (NIR)/magnetic resonance (MR) dual-modality imaging and magnetic targeting. The obtained DSSCe6@Fe3O4 NPs demonstrated a uniform nanospherical morphology consisting of Fe3O4 clusters...
March 3, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28255365/size-tunable-gd2o3-albumin-nanoparticles-conjugating-chlorin-e6-for-magnetic-resonance-imaging-guided-photo-induced-therapy
#18
Lijuan Zhou, Tao Yang, Junxing Wang, Qiaoli Wang, Xiaoyan Lv, Hengte Ke, Zhengqing Guo, Junkang Shen, Yong Wang, Chungen Xing, Huabing Chen
Protein nanoparticles as nanocarriers are of particular interest in the field of cancer therapy. Nevertheless, so far a facile fabrication of theranostic protein nanoparticles have been explored with limited success for cancer imaging and therapy. In this work, we demonstrate the controllable synthesis of size-tunable Gd2O3@albumin conjugating photosensitizer (PS) (GA-NPs) using hollow albumin as the nanoreactor for magnetic resonance imaging (MRI)-guided photo-induced therapy. The growth of Gd2O3 nanocrystals within the hollow nanoreactors is well regulated through reaction time, and a typical PS (e...
2017: Theranostics
https://www.readbyqxmd.com/read/28255343/hyaluronic-acid-conjugated-magnetic-prussian-blue-quantum-dot-nanoparticles-for-cancer-theranostics
#19
Yongbo Yang, Lijia Jing, Xiaoda Li, Li Lin, Xiuli Yue, Zhifei Dai
A multifunctional nanotheranostic agent was developed by conjugating both hyaluronic acid and bovine serum albumin coated CuInS2-ZnS quantum dots onto the surface of magnetic Prussian blue nanoparticles. The obtained nanoagent could serve as an efficient contrast agent to simultaneously enhance near infrared (NIR) fluorescence and magnetic resonance (MR) imaging greatly. The coexistence of magnetic core and CD44 ligand hyaluronic acid was found to largely improve the specific uptake of the nanoagent by CD44 overexpressed HeLa cells upon applying an external magnetic field...
2017: Theranostics
https://www.readbyqxmd.com/read/28250855/fdg-whole-body-pet-mri-in-oncology-a-systematic-review
#20
REVIEW
Hyun Woo Kwon, Ann-Katharina Becker, Jin Mo Goo, Gi Jeong Cheon
The recent advance in hybrid imaging techniques enables offering simultaneous positron emission tomography (PET)/magnetic resonance imaging (MRI) in various clinical fields. (18)F-fluorodeoxyglucose (FDG) PET has been widely used for diagnosis and evaluation of oncologic patients. The growing evidence from research and clinical experiences demonstrated that PET/MRI with FDG can provide comparable or superior diagnostic performance more than conventional radiological imaging such as computed tomography (CT), MRI or PET/CT in various cancers...
March 2017: Nuclear Medicine and Molecular Imaging
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