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https://www.readbyqxmd.com/read/28547820/future-of-medical-physics-real-time-mri-guided-proton-therapy
#1
Bradley M Oborn, Stephen Dowdell, Peter E Metcalfe, Stuart Crozier, Radhe Mohan, Paul J Keall
With the recent clinical implementation of real-time MRI guided x-ray beam therapy (MRXT), attention is therapy (MRPT). MRI guidance for proton beam therapy is expected to offer a compelling improvement to the turning to the concept of combining real-time MRI guidance with proton beam therapy; MRI guided proton beam current treatment workflow which is warranted arguably more than for x-ray beam therapy. This argument is born out of the fact that proton therapy toxicity outcomes are similar to that of the most advanced IMRT treatments, despite being a fundamentally superior particle for cancer treatment...
May 26, 2017: Medical Physics
https://www.readbyqxmd.com/read/28544159/simultaneous-measurement-of-t1-b1-and-pharmacokinetic-model-parameters-using-active-contrast-encoding-ace-mri
#2
Jin Zhang, Kerryanne Winters, Olivier Reynaud, Sungheon Gene Kim
The aim of this study was to assess the feasibility of combining dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) with the measurement of the radiofrequency (RF) transmit field B1 and pre-contrast longitudinal relaxation time T10 . A novel approach has been proposed to simultaneously estimate B1 and T10 from a modified DCE-MRI scan that actively encodes the washout phase of the curve with different amounts of T1 and B1 weighting using multiple flip angles and repetition times, hence referred to as active contrast encoding (ACE)-MRI...
May 22, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28543069/real-time-dynamic-mr-image-reconstruction-using-compressed-sensing-and-principal-component-analysis-cs-pca-demonstration-in-lung-tumor-tracking
#3
Bryson Dietz, Eugene Yip, Jihyun Yun, B Gino Fallone, Keith Wachowicz
PURPOSE: This work presents a real-time dynamic image reconstruction technique, that combines compressed sensing and principal component analysis (CS-PCA), to achieve real-time adaptive radiotherapy with the use of a linac-magnetic resonance imaging system. METHODS: Six retrospective fully sampled dynamic data sets of patients diagnosed with non-small cell lung cancer were used to investigate the CS-PCA algorithm. Using a database of fully sampled k-space, principal components (PC's) were calculated to aid in the reconstruction of undersampled images...
May 19, 2017: Medical Physics
https://www.readbyqxmd.com/read/28542622/meta-analysis-of-magnetic-resonance-imaging-accuracy-for-diagnosis-of-oral-cancer
#4
Marcelo Aldrighi Moreira, Luiza Silveira Lessa, Francieli Regina Bortoli, Abigail Lopes, Eduardo Picolo Xavier, Renan Antonio Ceretta, Fernanda Guglielmi Faustini Sônego, Cristiane Damiani Tomasi, Patricia Duarte Simões Pires, Luciane Bisognin Ceretta, Ingrid Dalira Schweigert Perry, Priscyla Waleska Simões
OBJECTIVE: To establish the diagnostic accuracy of magnetic resonance imaging (MRI) as an auxiliary means for the diagnosis of oral cancer through a systematic review and meta-analysis. METHODS: An exhaustive search of publications from 1986 to 2016 was performed of Medline, Embase and Cochrane (and related databases), including grey literature. Primary diagnostic accuracy studies that assessed oral cancer (target condition) using MRI (index test) were included...
2017: PloS One
https://www.readbyqxmd.com/read/28537455/efficacy-of-dipeptide-coated-magnetic-nanoparticles-in-lung-cancer-models-under-pulsed-electromagnetic-field
#5
Ganga Baskar, Mathangi Ravi, Jiban Jyoti Panda, Anjali Khatri, Bhawna Dev, Roy Santosham, Sekar Sathiya, Chidambaram Saravana Babu, Virander Singh Chauhan, Suresh K Rayala, Ganesh Venkatraman
Lung cancer is the leading cause of cancer deaths and the overall 5-year survival rate is less than 17%. Hyperthermia is an alternative approach for the treatment of lung cancer and is associated with fewer side effects. We employed ironoxide nanoparticles in inducing localized hyperthermia in lung cancer cells using a pulsed electromagnetic field (PEMF). We synthesized, characterized and determined the uptake of dipeptide-coated iron oxide nanoparticles. Further, their ability in inducing localized hyperthermia in PEMF on lung cancer cells was assessed...
May 24, 2017: Cancer Investigation
https://www.readbyqxmd.com/read/28531979/synthesis-and-characterization-of-glycyrrhizic-acid-coated-iron-oxide-nanoparticles-for-hyperthermia-applications
#6
Mostafa Saeedi, Omid Vahidi, Shahin Bonakdar
In the present study, iron oxide magnetic nanoparticles (IONPs) were synthesized using the oxidative precipitation method for biomedical applications. Glycyrrhizic acid (GA) extracted from the roots of licorice plant was used as the coating agent for the synthesized nanoparticles (GAIONPs). The crystal phase, morphology and size were investigated by XRD, FE-SEM and TEM. The saturation magnetization (ms) value of the nanoparticles was measured by VSM indicating lowered ms of the GAIONPs with respect to that of the IONPs due to the presence of GA...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530541/synthesis-of-new-antibacterial-cubane-based-nanocomposite-and-its-application-in-combination-cancer-therapy
#7
Elham Zakerzadeh, Roya Salehi, Mehrdad Mahkam
BACKGROUND: The need for therapeutically effective anticancer drug delivery systems constantly persuades researchers to explore novel strategies. OBJECTIVE: In this study a novel cubane based antibacterial nanocomposite was tailored as dual chemotherapy drug delivery vesicle in order to increase the therapeutic outcome in cancer therapy. METHOD: The physico-chemical characterization of engineered nanocarrier was assessed by Fourier transforms infrared spectroscopy (FTIR), Hydrogen nuclear magnetic resonance spectroscopy (1H NMR), Thermogravimetric analysis (TGA), and Field emission scanning electron microscopy-energy dispersive using X-ray (FESEM-EDX)...
May 22, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/28529648/elongated-nanoparticle-aggregates-in-cancer-cells-for-mechanical-destruction-with-low-frequency-rotating-magnetic-field
#8
Yajing Shen, Congyu Wu, Taro Q P Uyeda, Gustavo R Plaza, Bin Liu, Yu Han, Maciej S Lesniak, Yu Cheng
Magnetic nanoparticles (MNPs) functionalized with targeting moieties can recognize specific cell components and induce mechanical actuation under magnetic field. Their size is adequate for reaching tumors and targeting cancer cells. However, due to the nanometric size, the force generated by MNPs is smaller than the force required for largely disrupting key components of cells. Here, we show the magnetic assembly process of the nanoparticles inside the cells, to form elongated aggregates with the size required to produce elevated mechanical forces...
2017: Theranostics
https://www.readbyqxmd.com/read/28525950/hydrophobic-drug-loaded-pegylated-magnetic-liposomes-for-drug-controlled-release
#9
Andri Hardiansyah, Ming-Chien Yang, Ting-Yu Liu, Chih-Yu Kuo, Li-Ying Huang, Tzu-Yi Chan
Less targeted and limited solubility of hydrophobic-based drug are one of the serious obstacles in drug delivery system. Thus, new strategies to enhance the solubility of hydrophobic drug and controlled release behaviors would be developed. Herein, curcumin, a model of hydrophobic drug, has been loaded into PEGylated magnetic liposomes as a drug carrier platform for drug controlled release system. Inductive magnetic heating (hyperthermia)-stimulated drug release, in vitro cellular cytotoxicity assay of curcumin-loaded PEGylated magnetic liposomes and cellular internalization-induced by magnetic guidance would be investigated...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28525715/ultrasmall-magnetic-cufese2-ternary-nanocrystals-for-multimodal-imaging-guided-photothermal-therapy-of-cancer
#10
Xinxin Jiang, Shaohua Zhang, Feng Ren, Lei Chen, Jianfeng Zeng, Mo Zhu, Zhenxiang Cheng, Mingyuan Gao, Zhen Li
Nanoscale ternary chalcogenides have attracted intense research interest due to their wealth of tunable properties and diverse applications in energy and environmental and biomedical fields. In this article, ultrasmall magnetic CuFeSe2 ternary nanocrystals (<5.0 nm) were fabricated in the presence of thiol-functionalized poly(methacrylic acid) by an environmentally friendly aqueous method under ambient conditions. The small band gap and the existence of intermediate bands lead to a broad NIR absorbance in the range of 500-1100 nm and high photothermal conversion efficiency (82%) of CuFeSe2 nanocrystals...
May 25, 2017: ACS Nano
https://www.readbyqxmd.com/read/28525248/-magnetic-fields-and-health-from-epidemiology-to-cryptochrome-chemistry
#11
REVIEW
J Vanderstraeten
Biological effects of static magnetic fields (MF) and time-varying MF of electricity (50/60 Hz) appear possible from intensities in the low illitesla range. However, prolonged exposure to 50/60 Hz MF is associated with an increased risk of childhood leukemia at less than one microtesla of time-averaged intensity. And such kind of association is suggested in adults for some blood cancers and senile dementia. The cryptochrome hypothesis has been proposed to explain the association established with childhood leukemia...
2017: Revue Médicale de Bruxelles
https://www.readbyqxmd.com/read/28523317/mri-as-indicator-of-pulmonary-tuberculosis-activity-from-morphological-to-molecular-level-assessment-a-case-report
#12
Maria Teodora Antuaneta Buzan, Hanelore Herta, Mihaela Maria Coman, Daniela Homorodean, Silviu Andrei Sfrângeu, Carmen Monica Pop
We present the case of an adult patient with active post-primary pulmonary tuberculosis (TB) and discuss specific morphological and textural aspects found at high-field magnetic resonance imaging (MRI) of the lung. The 42-year-old man, heavy smoker, undertook a routine employment medical examination and was admitted to a referral pulmonology and TB center due to the abnormal findings seen on his chest radiography. The patient presented nonspecific symptoms, bilateral bronchial breath at pulmonary auscultation, inflammatory syndrome on the laboratory blood tests and positive sputum smears for acid-fast bacilli, which together with the typical aspect on the chest radiography lead to a diagnosis of post-primary pulmonary TB and administration of specific medication...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/28521959/cancer-cell-death-induced-by-nanomagnetolectin
#13
Dina M M AlSadek, Haitham A Badr, Tamer A Al-Shafie, Sabry M El-Bahr, Motawa E El-Houseini, Leyla B Djansugurova, Chen-Zhong Li, Hafiz Ahmed
Magnetic nanoparticles represent a new paradigm for molecular targeting therapy in cancer. However, the transformative targeting potential of magnetic nanoparticles has been stymied by a key obstacle-safe delivery to specified target cells in vivo. As cancer cells grow under nutrient deprivation and hypoxic conditions and decorate cell surface with excessive sialoglycans, sialic acid binding lectins might be suitable for targeting cancer cells in vivo. Here we explore the potential of magnetic nanoparticles functionalized with wheat germ lectin (WGA) conjugate, so-called nanomagnetolectin, as apoptotic targetable agents for prostate cancer...
May 10, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/28515411/evaluating-myometrial-invasion-in-endometrial-cancer-comparison-of-reduced-field-of-view-diffusion-weighted-imaging-and-dynamic-contrast-enhanced-mr-imaging
#14
Mayumi Takeuchi, Kenji Matsuzaki, Masafumi Harada
PURPOSE: To compare the diagnostic ability of reduced field-of-view (FOV) diffusion-weighted (DW) magnetic resonance (MR) imaging with that of three-dimensional (3D) dynamic contrast-enhanced (DCE) MR imaging in evaluating the depth of myometrial invasion in patients with endometrial cancer. METHODS: Three tesla (3T) MR images including T2-weighted imaging, reduced FOV DW imaging and 3D DCE MR imaging in sagittal and oblique axial (short axis) planes in 25 women with surgically proven endometrial cancer were retrospectively evaluated...
May 18, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28511960/inadequate-target-volume-delineation-and-local-regional-recurrence-after-intensity-modulated-radiotherapy-for-human-papillomavirus-positive-oropharynx-cancer
#15
Allen M Chen, Robert Chin, Philip Beron, Taeko Yoshizaki, Argin G Mikaeilian, Minsong Cao
PURPOSE: To perform a spatial analysis of local-regional recurrences, in relation to quantitative dose distribution, among patients treated by intensity-modulated radiotherapy (IMRT) for human papillomavirus (HPV)-positive oropharyngeal cancer. METHODS AND MATERIALS: The records of 107 consecutive patients who presented for consideration of re-irradiation for local-regional recurrent disease occurring in a previously irradiated field were reviewed. The original IMRT plans were retrieved for those with HPV-positive disease originating from the oropharynx, and deformable image registration was used to fuse the magnetic resonance imaging (MRI) and positron emission tomography (PET) scans obtained at recurrence to the pre-treatment planning computed tomography (CT) dataset...
May 13, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28508759/mri-trus-fusion-for-electrode-positioning-during-irreversible-electroporation-for-treatment-of-prostate-cancer
#16
Alexander D J Baur, Federico Collettini, Judith Enders, Andreas Maxeiner, Vera Schreiter, Carsten Stephan, Bernhard Gebauer, Bernd Hamm, Thomas Fischer
We aimed to introduce an approach for image-guided positioning of electrodes for irreversible electroporation (IRE) in patients with prostate cancer using a magnetic resonance imaging-transrectal ultrasonography (MRI-TRUS) fusion technique. In 10 consecutive patients with biopsy-proven Gleason score ≤3+4 prostate cancer, 19 G electrodes were inserted into the prostate using a transperineal access. Magnetic resonance images of the prostate acquired before IRE were fused with transrectal ultrasound images acquired during IRE...
May 15, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28508129/development-and-characterization-of-magnetite-poly-butylcyanoacrylate-nanoparticles-for-magnetic-targeted-delivery-of-cancer-drugs
#17
Margarita López-Viota, Mazen M El-Hammadi, Laura Cabeza, José Prados, Consolación Melguizo, M Adolfina Ruiz Martinez, José L Arias, Ángel V Delgado
A great attention is presently paid to the design of drug delivery vehicles based on surface-modified magnetic nanoparticles. They can, in principle, be directed to a desired target area for releasing their drug payload, a process triggered by pH, temperature, radiation, or even magnetic field. To this, the possibility of forming part of diagnostic tools by enhanced magnetic resonance imaging or that of further treatment by magnetic hyperthermia can be added. Bare particles are rapidly eliminated from the bloodstream by the phagocyte mononuclear system, leading to short biological half-life...
May 15, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28506802/stealth-magnetic-nanocarriers-of-sirna-as-platform-for-breast-cancer-theranostics
#18
J Bruniaux, S Ben Djemaa, K Hervé-Aubert, H Marchais, I Chourpa, S David
The endogenous mechanism of RNA interference is more and more used in research to obtain specific down-regulation of gene expression in diseases such as breast cancer. Currently, despite the new fields of study open up by RNA interference, the rapid degradation of siRNA by nucleases and their negative charges prevent them from crossing cell membranes. To overcome these limitations, superparamagnetic iron oxide nanoparticles (SPIONs) represent a promising alternative for nucleic acid delivery. Previously, we reported the magnetic siRNA nanovectors (MSN) formulation using electrostatic assembly of (1) SPIONs, also able to act as contrast agents for magnetic resonance imaging (MRI), (2) siRNA and (3) chitosan aiming at their protection and enhancing their transfection efficacy...
May 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28492507/core-shell-magnetic-gold-nanoparticles-for-magnetic-field-enhanced-radio-photothermal-therapy-in-cervical-cancer
#19
Rui Hu, Minxue Zheng, Jinchang Wu, Cheng Li, Danqing Shen, Dian Yang, Li Li, Mingfeng Ge, Zhimin Chang, Wenfei Dong
The combination of radiotherapy (RT) and photothermal therapy (PTT) has been considered an attractive strategy in cervical cancer treatment. However, it remains a challenge to simultaneously enhance the radio-sensitivity of tumor tissue, develop tumor tissue-focused radiation therapies and combine dual therapeutic modalities. In this study, core-shell type magnetic gold (Fe₃O₄@Au) nanoparticles are exploited to achieve the synergistic efficacy of radio-photothermal therapy in cervical cancer. Fe₃O₄@Au nanoparticles (NPs) with uniform morphology exhibited superior surface plasmon resonance properties, excellent superparamagnetic properties, good biocompatibility and high photothermal conversion efficiency...
May 11, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28490761/nanoscale-brownian-heating-by-interacting-magnetic-dipolar-particles
#20
Yann Chalopin, Jean-Claude Bacri, Florence Gazeau, Martin Devaud
Clusters of magnetic nanoparticles have received considerable interest in various research fields. Their capacity to generate heat under an alternating magnetic field has recently opened the way to applications such as cancer therapy by hyperthermia. This work is an attempt to investigate the collective effects of interacting dipoles embedded in magnetic nano-particles (MNP) to predict their thermal dissipation with a liquid. We first present a general approach, based on the tracking of the microscopic dipole fluctuations, to access to the dissipation spectra of any spatial distribution of MNPs...
May 10, 2017: Scientific Reports
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