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https://www.readbyqxmd.com/read/28809934/long-term-exposure-to-air-pollution-and-the-incidence-of-parkinson-s-disease-a-nested-case-control-study
#1
Chiu-Ying Chen, Hui-Jung Hung, Kuang-Hsi Chang, Chung Y Hsu, Chih-Hsin Muo, Chon-Haw Tsai, Trong-Neng Wu
BACKGROUND: Previous studies revealed that chronic exposure to air pollution can significantly increase the risk of the development of Parkinson's disease (PD), but this relationship is inconclusive as large-scale prospective studies are limited and the results are inconsistent. Therefore, the purpose of this study was to ascertain the adverse health effects of air pollution exposure in a nationwide population using a longitudinal approach. MATERIALS AND METHODS: We conducted a nested case-control study using the National Health Insurance Research Dataset (NHIRD), which consisted of 1,000,000 beneficiaries in the National Health Insurance Program (NHI) in the year 2000 and their medical records from 1995 to 2013 and using public data on air pollution concentrations from monitoring stations across Taiwan released from the Environmental Protection Administration to identify people with ages ≥ 40 years living in areas with monitoring stations during 1995-1999 as study subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28799488/environment-and-neurodegenerative-diseases-an-update-on-mirna-role
#2
Margherita Ferrante, Gea Oliveri Conti
INTRODUCTION: The importance of neurodegenerative diseases on the management of public health is growing and the real role of the environment and miRNA in their occurrence is still unclear. miRNA can affect significantly the regulatory network. The complex variety and gene-regulatory capacity of miRNAs is particularly valuable in the brain, being a very complex organ with a functional specialization of neurons highly adaptable to environmental stimuli. In particular a miRNAs role is demonstrated in neurological diseases as the effect to toxic and mutagenic substances exposure by the environment...
August 11, 2017: MicroRNA
https://www.readbyqxmd.com/read/28779877/occupational-pesticide-use-and-parkinson-s-disease-in-the-parkinson-environment-gene-peg-study
#3
Shilpa Narayan, Zeyan Liew, Jeff M Bronstein, Beate Ritz
OBJECTIVE: To study the influence of occupational pesticide use on Parkinson's disease (PD) in a population with information on various occupational, residential, and household sources of pesticide exposure. METHODS: In a population-based case control study in Central California, we used structured interviews to collect occupational history details including pesticide use in jobs, duration of use, product names, and personal protective equipment use from 360 PD cases and 827 controls...
August 2, 2017: Environment International
https://www.readbyqxmd.com/read/28757096/clinical-effects-of-chemical-exposures-on-mitochondrial-function
#4
Zarazuela Zolkipli-Cunningham, Marni J Falk
Mitochondria are critical for the provision of ATP for cellular energy requirements. Tissue and organ functions are dependent on adequate ATP production, especially when energy demand is high. Mitochondria also play a role in a vast array of important biochemical pathways including apoptosis, generation and detoxification of reactive oxygen species, intracellular calcium regulation, steroid hormone and heme synthesis, and lipid metabolism. The complexity of mitochondrial structure and function facilitates its diverse roles but also enhances its vulnerability...
July 27, 2017: Toxicology
https://www.readbyqxmd.com/read/28610994/manganese-induced-sex-specific-gut-microbiome-perturbations-in-c57bl-6-mice
#5
Liang Chi, Bei Gao, Xiaoming Bian, Pengcheng Tu, Hongyu Ru, Kun Lu
Overexposure to manganese (Mn) leads to toxic effects, such as promoting the development of Parkinson's-like neurological disorders. The gut microbiome is deeply involved in immune development, host metabolism, and xenobiotics biotransformation, and significantly influences central nervous system (CNS) via the gut-brain axis, i.e. the biochemical signaling between the gastrointestinal tract and the CNS. However, it remains unclear whether Mn can affect the gut microbiome and its metabolic functions, particularly those linked to neurotoxicity...
June 10, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/28598268/effects-of-pulmonary-exposure-to-chemically-distinct-welding-fumes-on-neuroendocrine-markers-of-toxicity
#6
K Krajnak, K Sriram, C Johnson, J R Roberts, R Mercer, G R Miller, O Wirth, J M Antonini
Exposure to welding fumes may result in disorders of the pulmonary, cardiovascular, and reproductive systems. Welders are also at a greater risk of developing symptoms similar to those seen in individuals with idiopathic Parkinson's disease. In welders, there are studies that suggest that alterations in circulating prolactin concentrations may be indicative of injury to the dopamine (DA) neurons in the substantia nigra. The goal of these studies was to use an established model of welding particulate exposure to mimic the effects of welding fume inhalation on reproductive functions...
2017: Journal of Toxicology and Environmental Health. Part A
https://www.readbyqxmd.com/read/28552054/neurotoxicity-of-insecticides
#7
Julien Cassereau, Marc Ferré, Arnaud Chevrollier, Philippe Codron, Christophe Verny, Chadi Homedan, Guy Lenaers, Vincent Procaccio, Pascale May-Panloup, Pascal Reynier
BACKGROUND: Human exposure to insecticides raises serious public health concerns worldwide. Insecticides constitute a wide-ranging heterogeneous group of chemicals, most of which target the nervous system and disrupt neurometabolism and/or neurotransmission. Although the acute effects of insecticide poisoning in humans are well documented, the chronic and long-term effects remain difficult to investigate. OBJECTIVES AND METHOD: We sought to review the present state-of-knowledge of acute, chronic, neurodevelopmental and neurological consequences of human exposure to insecticides...
May 26, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28541558/drinking-water-contamination-from-perfluoroalkyl-substances-pfas-an-ecological-mortality-study-in-the-veneto-region-italy
#8
Marina Mastrantonio, Edoardo Bai, Raffaella Uccelli, Vincenzo Cordiano, Augusto Screpanti, Paolo Crosignani
: Perfluoroalkyl substances (PFAS), a heterogeneous group of highly stable man-made chemicals, have been widely used since 1960s and can be detected almost ubiquitously in all environmental matrices. In Italy, on January 2014, drinking water contamination in an area of the Veneto Region was detected mainly due to the drain of fluorinated chemicals by a manufacturing company operating since 1964. : The present ecological mortality study was aimed at comparing mortality for some causes of death selected on the basis of previous reported associations, during the period 1980-2013, in municipalities with PFAS contaminated and uncontaminated drinking water on the basis of the levels indicated by the Italian National Health Institute (ISS)...
May 23, 2017: European Journal of Public Health
https://www.readbyqxmd.com/read/28506248/paraquat-and-parkinson-s-disease-a-systematic-review-protocol-according-to-the-ohat-approach-for-hazard-identification
#9
Carolina Vaccari, Regina El Dib, João Lauro V de Camargo
BACKGROUND: Parkinson's disease (PD) is a progressive neurodegenerative condition that has genetic susceptibility, aging, and exposure to certain chemicals as risk factors. In recent decades, epidemiological and experimental studies have investigated the role of pesticides in the development of PD, in particular that of the herbicide paraquat. Here, we, therefore, aim to systematically review the association between paraquat exposure and PD. METHODS: Observational studies (cohort, case-control, and cross-sectional) eligible for this systematic review will enroll any participant who was occupationally and/or environmentally exposed to paraquat...
May 15, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28505322/exosomes-in-toxicology-relevance-to-chemical-exposure-and-pathogenesis-of-environmentally-linked-diseases
#10
Dilshan S Harischandra, Shivani Ghaisas, Dharmin Rokad, Anumantha G Kanthasamy
Chronic exposure to environmental toxins has been known to initiate or aggravate various neurological disorders, carcinomas and other adverse health effects. Uptake by naïve cells of pathogenic factors such as danger-associated molecules, mRNAs, miRNAs or aggregated proteins leads to disruption in cellular homeostasis further resulting in inflammation and disease propagation. While early research tended to focus solely on exosomal removal of unwanted cellular contents, more recent reports indicate that these nano-vesicles play an active role in intercellular signaling...
May 15, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28382610/the-role-of-mitochondrial-aldehyde-dehydrogenase-2-aldh2-in-neuropathology-and-neurodegeneration
#11
Che-Hong Chen, Amit U Joshi, Daria Mochly-Rosen
Aldehydes-induced toxicity has been implicated in many neurodegenerative diseases. Exposure to reactive aldehydes from (1) alcohol and food metabolism; (2) environmental pollutants, including car, factory exhausts, smog, pesticides, herbicides; (3) metabolism of neurotransmitters, amino acids and (4) lipid peroxidation of biological membrane from excessive ROS, all contribute to 'aldehydic load' that has been linked to the pathology of neurodegenerative diseases. In particular, the α, β-unsaturated aldehydes derived from lipid peroxidation, 4-hydroxynonenal (4-HNE), DOPAL (MAO product of dopamine), malondialdehyde, acrolein and acetaldehyde, all readily form chemical adductions with proteins, DNA and lipids, thus causing neurotoxicity...
December 15, 2016: Acta Neurologica Taiwanica
https://www.readbyqxmd.com/read/27983596/estrogenic-endocrine-disrupting-chemicals-influencing-nrf1-regulated-gene-networks-in-the-development-of-complex-human-brain-diseases
#12
REVIEW
Mark Preciados, Changwon Yoo, Deodutta Roy
During the development of an individual from a single cell to prenatal stages to adolescence to adulthood and through the complete life span, humans are exposed to countless environmental and stochastic factors, including estrogenic endocrine disrupting chemicals. Brain cells and neural circuits are likely to be influenced by estrogenic endocrine disruptors (EEDs) because they strongly dependent on estrogens. In this review, we discuss both environmental, epidemiological, and experimental evidence on brain health with exposure to oral contraceptives, hormonal therapy, and EEDs such as bisphenol-A (BPA), polychlorinated biphenyls (PCBs), phthalates, and metalloestrogens, such as, arsenic, cadmium, and manganese...
December 13, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27979718/neonatal-rotenone-lesions-cause-onset-of-hyperactivity-during-juvenile-and-adulthood-in-the-rat
#13
Masami Ishido, Junko Suzuki, Yoshinori Masuo
Attention deficit hyperactivity disorder (ADHD) is characterized by behavioral and cognitive symptoms. Longitudinal studies demonstrated that the symptoms remains clinically significant for the majority of ADHD children into adulthood. Furthermore, a population-based birth cohort provided the initial evidence of adult ADHD that lacks a history of childhood ADHD. We previously demonstrated that neonatal exposure to bisphenol A, an environmental chemical caused hyperactivity in the juvenile. Here, we extend to examine other chemical such as rotenone, a dopaminergic toxins...
January 15, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/27937005/sorbus-alnifolia-protects-dopaminergic-neurodegeneration-in-caenorhabditis-elegans
#14
Se-Myeong Cheon, Insoo Jang, Myon-Hee Lee, Dae Keun Kim, Hoon Jeon, Dong Seok Cha
CONTEXT: The twigs of Sorbus alnifolia (Sieb. et Zucc.) K. Koch (Rosaceae) have been used to treat neurological disorders as a traditional medicine in Korea. However, there are limited data describing the efficacy of S. alnifolia in Parkinson's disease (PD). OBJECTIVE: This study was conducted to identify the protective effects of the methanol extracts of S. alnifolia (MESA) on the dopaminergic (DA) neurodegeneration in Caenorhabditis elegans. MATERIALS AND METHODS: To test the neuroprotective action of MESA, viability assay was performed after 48 h exposure to 1-methyl-4-phenylpyridine (MMP(+)) in PC12 cells and C...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27736935/chemical-compensation-of-mitochondrial-phospholipid-depletion-in-yeast-and-animal-models-of-parkinson-s-disease
#15
Shaoxiao Wang, Siyuan Zhang, Chuan Xu, Addie Barron, Floyd Galiano, Dhaval Patel, Yong Joo Lee, Guy A Caldwell, Kim A Caldwell, Stephan N Witt
We have been investigating the role that phosphatidylethanolamine (PE) and phosphatidylcholine (PC) content plays in modulating the solubility of the Parkinson's disease protein alpha-synuclein (α-syn) using Saccharomyces cerevisiae and Caenorhabditis elegans. One enzyme that synthesizes PE is the conserved enzyme phosphatidylserine decarboxylase (Psd1/yeast; PSD-1/worms), which is lodged in the inner mitochondrial membrane. We previously found that decreasing the level of PE due to knockdown of Psd1/psd-1 affects the homeostasis of α-syn in vivo...
2016: PloS One
https://www.readbyqxmd.com/read/27717874/pharmaceutical-development-of-novel-lactate-based-6-fluoro-l-dopa-formulations
#16
Nunzio Denora, Angela Lopedota, Modesto de Candia, Saverio Cellamare, Leonardo Degennaro, Renzo Luisi, Antonietta Mele, Domenico Tricarico, Annalisa Cutrignelli, Valentino Laquintana, Cosimo D Altomare, Massimo Franco, Vincenzo Dimiccoli, Anna Tolomeo, Antonio Scilimati
6-[(18)F]fluoro-l-dihydroxyphenylalanine ((18)F-DOPA) is a diagnostic positron emission tomography (PET) agent, which has been used for decades in imaging the loss of dopaminergic neurons in Parkinson's disease, and more recently to detect, stage and restage neuroendocrine tumors (NETs) and to search for recurrence of viable glioma tissue. The commercially available (18)F-DOPA PET radiopharmaceutical for diagnostic use in European Union countries, is formulated in an aqueous solution of acetic acid (1.05mg/mL) and has the disadvantages that, immediately before injection, the pH must be adjusted to 4...
March 1, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27556455/novel-redox-dependent-esterase-activity-ec-3-1-1-2-for-dj-1-implications-for-parkinson-s-disease
#17
Emmanuel Vázquez-Mayorga, Ángel G Díaz-Sánchez, Ruben K Dagda, Carlos A Domínguez-Solís, Raul Y Dagda, Cynthia K Coronado-Ramírez, Alejandro Martínez-Martínez
Mutations the in human DJ-1 (hDJ-1) gene are associated with early-onset autosomal recessive forms of Parkinson's disease (PD). hDJ-1/parkinsonism associated deglycase (PARK7) is a cytoprotective multi-functional protein that contains a conserved cysteine-protease domain. Given that cysteine-proteases can act on both amide and ester substrates, we surmised that hDJ-1 possessed cysteine-mediated esterase activity. To test this hypothesis, hDJ-1 was overexpressed, purified and tested for activity towards 4-nitrophenyl acetate (pNPA) as µmol of pNPA hydrolyzed/min/mg·protein (U/mg protein)...
August 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27455809/-link-between-aluminum-neurotoxicity-and-neurodegenerative-disorders
#18
Masahiro Kawahara
Aluminum is an old element that has been known for a long time, but some of its properties are only now being discovered. Although environmentally abundant, aluminum is not essential for life; in fact, because of its specific chemical properties, aluminum inhibits more than 200 biologically important functions and exerts various adverse effects in plants, animals, and humans. Aluminum is a widely recognized neurotoxin. It has been suggested that there is a relationship between exposure to aluminum and neurodegenerative diseases, including dialysis encephalopathy, amyotrophic lateral sclerosis and parkinsonism dementia in the Kii Peninsula and Guam, as well as Alzheimer' s disease: however, this claim remains to be verified...
July 2016: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/27344208/neurodegeneration-in-tauopathies-and-synucleinopathies
#19
C Foguem, B Kamsu-Foguem
While increasing life expectancy is a major achievement, the global aging of societies raises a number of medical issues, such as the development of age-related disorders, including neurodegenerative diseases. The three main disease groups constituting the majority of neurodegenerative diseases are tauopathies, alpha-synucleinopathies and diseases due to repetitions of glutamine (including Huntington's disease). In each neurodegenerative disease, the accumulation of one or more aggregated proteins has been identified as the molecular signature of the disease (as seen, for example, in Alzheimer's disease, Parkinson's disease, dementia with Lewy bodies, amyotrophic lateral sclerosis and frontotemporal dementia)...
November 2016: Revue Neurologique
https://www.readbyqxmd.com/read/27311820/melanin-and-neuromelanin-binding-of-drugs-and-chemicals-toxicological-implications
#20
REVIEW
Oskar Karlsson, Nils Gunnar Lindquist
Melanin is a polyanionic pigment that colors, e.g., the hair, skin and eyes. The pigment neuromelanin is closely related to melanin and is mainly produced in specific neurons of the substantia nigra. Certain drugs and chemicals bind to melanin/neuromelanin and are retained in pigment cells for long periods. This specific retention is thought to protect the cells but also to serve as a depot that slowly releases accumulated compounds and may cause toxicity in the eye and skin. Moreover, neuromelanin and compounds with high neuromelanin affinity have been suggested to be implicated in the development of adverse drug reactions in the central nervous system (CNS) as well as in the etiology of Parkinson's disease (PD)...
August 2016: Archives of Toxicology
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