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https://www.readbyqxmd.com/read/28095031/the-role-of-drug-and-alcohol-use-and-the-risk-of-motor-vehicle-crashes-in-shiraz-iran-2014-a-case-crossover-study
#1
Narges Khanjani, Masoomeh Mousavi, Amirreza Dehghanian, Yunes Jahani, Hamid Souri
BACKGROUND: Traffic accidents and traffic-related injuries and mortality have become a major public health concern over the current years in Iran. This study aimed to examine the role of drug and alcohol use in motor vehicle accidents in Iran. METHODS: This case-crossover study was conducted on 441 drivers who survived from a road traffic crash and were taken to the emergency department of Shahid Rajaee trauma hospital in Shiraz, southern Iran. Data were collected using checklists which included demographic characteristics and drug and alcohol use prior to driving...
January 17, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28059034/midazolam-plus-haloperidol-as-adjuvant-analgesics-to-morphine-in-opium-dependent-patients-a-randomized-clinical-trial
#2
Mohammad Afzalimoghaddam, Maryam Edalatifard, Amir Nejati, Mehdi Momeni, Nader Isavi, Ehsan Karimialavijeh
BACKGROUND: Tolerance to opioids among opium-dependent patients creates obstacles for proper pain management of these patients in the emergency department (ED). The aim of the present study was to investigate the efficacy of intramuscular (IM) haloperidol plus midazolam on morphine analgesia among opium-dependent patients. METHODS: Opium-dependent adults who were admitted to the ED for new-onset severe pain in the limbs or abdomen (within 24 hours of admission and a pain score of over six, using a numerical rating scale [NRS]) were recruited...
January 6, 2017: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/28050181/factors-associated-with-depressive-symptoms-in-young-adults-with-coronary-artery-disease-tehran-heart-center-s-premature-coronary-atherosclerosis-cohort-thc-pac-study
#3
Seyed Hesameddin Abbasi, Seyed Ebrahim Kassaian, Saeed Sadeghian, Abbasali Karimi, Soheil Saadat, Flora Peyvandi, Arash Jalali, Tahereh Davarpasand, Shahin Akhondzadh, Nazila Shahmansouri, Masoumeh Lotfi-Tokaldany, Maryam Amiri Abchouyeh, Farah Ayatollahzade Isfahani, Frits Rosendaal
Objective: Depressed coronary artery disease (CAD) patients may experience a poorer prognosis than non-depressed patients. The aim of this study was to find the associated factors for depressive symptoms in young adults with CAD. Method: This was a cross-sectional study within Tehran Heart Center's Premature Coronary Atherosclerosis Cohort (THC-PAC) study. Young adult CAD patients (men ≤ 45 year-old and women ≤ 55 year-old) were visited from March 2013 to February 2014. Demographic, clinical and laboratory data were collected and all patients were asked to fill in the Beck Depression Inventory II...
October 2016: Iranian Journal of Psychiatry
https://www.readbyqxmd.com/read/28042065/civil-society-driven-drug-policy-reform-for-health-and-human-welfare-india
#4
Nandini Vallath, Tripti Tandon, Tania Pastrana, Diederik Lohman, S Asra Husain, James Cleary, Ganpati Ramanath, M R Rajagopal
The lack of adequate access to opioids in India as analgesics and for agonist therapies, forces millions to live with severe unalleviated pain, or languish with suffering associated with drug dependence. Although India is a major opium exporter, the excessively prohibitive 1985 narcotics law formulated to control harmful use of drugs, impeded the availability and access to opioids for medical and scientific purposes. Amendment of this law in 2014 established a new national regulatory framework for improved access to essential opioid analgesics...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28040448/randomized-clinical-trial-of-postoperative-belladonna-and-opium-rectal-suppositories-in-vaginal-surgery
#5
K Butler, J Yi, M Wasson, J Klauschie, D Ryan, J Hentz, J Cornella, P Magtibay, R Kho
BACKGROUND: Following vaginal surgery oral and parenteral narcotics are commonly used for pain relief and their use may exacerbate the incidence of sedation, nausea, and vomiting; ultimately delaying convalescence. Previous studies have demonstrated that rectal analgesia following surgery results in lower pain scores and less intravenous morphine consumption. Belladonna and opium (B&O) rectal suppositories may be used to relieve pain and minimize side effects; however their efficacy has not been confirmed...
December 28, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28036099/can-drugs-induce-or-aggravate-sleep-apneas-a-case-non-case-study-in-vigibase-%C3%A2-the-who-pharmacovigilance-database
#6
Mélanie Linselle, Agnès Sommet, Emmanuelle Bondon-Guitton, Florence Moulis, Geneviève Durrieu, Justine Benevent, Vanessa Rousseau, Leila Chebane, Haleh Bagheri, François Montastruc, Jean-Louis Montastruc
The potential favorising role of drugs in Sleep Apnea Syndrome (SAS) is unknown. The present study investigates drugs associated with SAS in a pharmacovigilance database. SAS recorded as Adverse Drug Reactions (ADRs) in Vigibase(®) , the WHO pharmacovigilance database (more than 11 million reports), from 1978 to 2015 were selected. The risk of SAS reports was estimated using the case non-case method, with cases being SAS and non-cases all other recorded ADRs. During this 37-year period, 3,325 ADRs including the word SAS were registered (0...
December 30, 2016: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28008394/does-opium-dependency-affect-the-pattern-of-involvement-in-laryngeal-cancer
#7
Peyman Dabirmoghaddam, Ali Karimian Taheri, Hosein Ghazavi, Shaghayegh Ebrahimnejad, Zahra Karimian
INTRODUCTION: Laryngeal cancer is the second most common cancer involving the respiratory tract, second only to lung cancer. Previous studies have shown opium dependency to be a possible risk factor for laryngeal cancer. Opium consumption is a major problem in some parts of the world. The aim of this study was to investigate the effect of opium consumption on the pattern of involvement in laryngeal cancer. METHODS AND MATERIALS: In this analytical cross-sectional study, 44 patients diagnosed with laryngeal cancer (41 male and three female) were studied...
November 2016: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/27991536/genes-encoding-norcoclaurine-synthase-occur-as-tandem-fusions-in-the-papaveraceae
#8
Jing Li, Eun-Jeong Lee, Limei Chang, Peter J Facchini
Norcoclaurine synthase (NCS) catalyzes the enantioselective Pictet-Spengler condensation of dopamine and 4-hydroxyphenylacetaldehyde as the first step in benzylisoquinoline alkaloid (BIA) biosynthesis. NCS orthologs in available transcriptome databases were screened for variants that might improve the low yield of BIAs in engineered microorganisms. Databases for 21 BIA-producing species from four plant families yielded 33 assembled contigs with homology to characterized NCS genes. Predicted translation products generated from nine contigs consisted of two to five sequential repeats, each containing most of the sequence found in single-domain enzymes...
December 19, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27957439/can-opium-use-contribute-to-a-higher-risk-of-colorectal-cancers-a-matched-case-control-study-in-iran
#9
Ahmad Naghibzadeh-Tahami, Vahid Yazdi Feyzabadi, Narges Khanjani, Ahad Ashrafi-Asgarabad, Hosniyeh Alizaeh, Vahid Reza Borhaninejad, Mohammad Moradi-Joo, Masoud Zeinali, Mohammad Javad Zahedi, Mahmoud Aghaee-Afshar, Ali Akbar Haghdoost
BACKGROUND: Colorectal cancers (CRCs) including colon, rectum and anal cancers are the third most prevalent cancers in the world. There are strong evidence showing the risk of the cigarette smoking, alcohol use, low physical activity and some types of diets in CRCs; however, few studies explored the relationship between opium use and CRCs. This study aimed to investigate the association between opioid use and the incidence of CRCs. METHODS: In a population-based matched case-control study in Kerman, Iran, 175 patients with colorectal cancers and 350 healthy controls (matched for age, sex, and place of residence) were interviewed from Sep 2014 to Nov 2014...
October 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/27957289/efficacy-of-endoscopic-ultrasonography-in-evaluation-of-undetermined-etiology-of-common-bile-duct-dilatation-on-abdominal-ultrasonography
#10
Rasoul Sotoudehmanesh, Naimeh Nejati, Maryam Farsinejad, Shadi Kolahdoozan
BACKGROUND The cause of common bile duct (CBD) dilatation cannot be determined by imaging modalities in many patients. The aim of this study was to assess the value of endoscopic ultrasonography (EUS) in detecting the cause of CBD dilatation in patients in whom ultrasonography could not demonstrate the cause of dilation. METHODS Prospectively, 152 consecutive patients who were referred for evaluation of dilated CBD (diameter ≥7 mm) of undetermined origin by ultrasonography were included in this study. All the patients underwent EUS...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957288/esophageal-cancer-in-golestan-province-iran-a-review-of-genetic-susceptibility-and-environmental-risk-factors
#11
REVIEW
Mahin Gholipour, Farhad Islami, Gholamreza Roshandel, Masoud Khoshnia, Abbas Badakhshan, Abdolvahab Moradi, Reza Malekzadeh
Esophageal squamous cell carcinoma (ESCC) is an aggressive tumor that is typically diagnosed only when the tumor has gained remarkable size, extended to peripheral tissues, and led to dysphagia. Five-year survival of advanced cancer is still very poor (19%), even with improved surgical techniques and adjuvant chemoradiation therapy. Therefore, early detection and prevention are the most important strategies to reduce the burden of ESCC. Our review will focus on the studies conducted in Golestan province, an area with a high prevalence of ESCC in northern Iran...
October 2016: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27957254/outcomes-and-long-term-survival-of-coronary-artery-surgery-the-controversial-role-of-opium-as-risk-marker
#12
Mahdi Najafi, Leila Jahangiry, Seyedeh Hamideh Mortazavi, Arash Jalali, Abbasali Karimi, Ali Bozorgi
AIM: To study survival in isolated coronary artery bypass graft (CABG) patients and to evaluate the impact of preoperative chronic opium consumption on long-term outcome. METHODS: Cohort of 566 isolated CABG patients as Tehran Heart Center cardiac output measurement was conducted. Daily evaluation until discharge as well as 4- and 12-mo and 6.5-year follow-up information for survival status were fulfilled for all patients. Long-term 6.5-year overall and opium-stratified survival, adjusted survival curves based on opium consumption as well as possible predictors of all-cause mortality using multiple cox regression were determined by statistical analysis...
November 26, 2016: World Journal of Cardiology
https://www.readbyqxmd.com/read/27896238/retroperitoneal-fibrosis-due-to-opium-abuse-a-case-series-and-literature-review
#13
Mohammad Ali Mohammadzadeh Rezaei, Alireza Akhavan Rezayat, Shima Ardalan
Retroperitoneal fibrosis (RPF) is a rare condition with an unclear etiology, presenting with the development of aberrant chronic nonspecific fibroinflammatory tissue in the retroperitoneal space, which can result in entrapment and obstruction of the retroperitoneal structures. RPF is a subtype of chronic periaortitis, and can be divided into two types: primary (or idiopathic) and secondary. RPF is usually idiopathic, but can also be secondary to malignancies, certain drugs, infections, surgery, and trauma. The systemic clinical manifestations are nonspecific and include low-grade fever, fatigue, anorexia, weight loss, and myalgia...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27885167/mortality-from-respiratory-diseases-associated-with-opium-use-a-population-based-cohort-study
#14
Atieh Rahmati, Ramin Shakeri, Hooman Khademi, Hossein Poutschi, Akram Pourshams, Arash Etemadi, Masoud Khoshnia, Amir Ali Sohrabpour, Ali Aliasgari, Elham Jafari, Farhad Islami, Shahryar Semnani, Abdolsamad Gharravi, Christian C Abnet, Paul D P Pharoah, Paul Brennan, Paolo Boffetta, Sanford M Dawsey, Reza Malekzadeh, Farin Kamangar
BACKGROUND: Recent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data. METHODS: We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures...
November 24, 2016: Thorax
https://www.readbyqxmd.com/read/27882209/marketed-new-drug-delivery-systems-for-opioid-agonists-antagonists-administration-a-rapid-overview
#15
REVIEW
Hoda Soltani, Abbas Pardakhty
Novel drug delivery systems for controlled-release of opioid agonists as a long time painkillers or opioid antagonists for opium, heroin, and alcohol addiction are under development or in clinical use today. In this article, the field of "new drug delivery systems" is momentarily reviewed from the viewpoint of the marketed opioid agonists/antagonists dosage forms today.
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27882205/sleep-disorders-in-methadone-maintenance-treatment-volunteers-and-opium-dependent-patients
#16
Habibolah Khazaie, Farid Najafi, Mohammad Rasoul Ghadami, Atena Azami, Marzieh Nasouri, Masoud Tahmasian, Behnam Khaledi-Paveh
BACKGROUND: The relationship between substance use and sleep is bidirectional. Substance use directly causessleep disturbances, and sleep problems are a critical factor in substance-use relapse. METHODS: This study evaluated sleep disorders in 65 methadone maintenance treatment (MMT) patients, and61 opium-dependent patients who did not receive any treatment between September 2011 and July 2012 inKermanshah, Iran. Both groups filled out the Pittsburgh Sleep Quality Index (PSQI) and Global SleepAssessment Questionnaire (GSAQ)...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27882204/comparison-of-quantitative-and-qualitative-dermatoglyphic-characteristics-of-opium-addicts-with-healthy-individuals
#17
Omid Mehrpour, Ardeshir Sheikhazadi, Afsoon Barzegar, Afzal Husein, Claudia Malic, Elham Sheikhazadi, Seyed Hossein Saberi-Anary
BACKGROUND: Recreational drugs have a significant impact on the lives of drug users, their close families andfriends, as well as their society. Social, psychological, biological, and genetic factors could make a personmore prone to using recreational drugs. Finger and A-B ridges (dermatoglyphics) are formed during the firstand second trimesters of fetal development, under the influence of environmental and genetic factors. Theaim of our study was to investigate and evaluate a possible link between dermatoglyphics and opium usage...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27872345/hazards-of-cigarettes-smokeless-tobacco-and-waterpipe-in-a-middle-eastern-population-a-cohort-study-of-50%C3%A2-000-individuals-from-iran
#18
Arash Etemadi, Hooman Khademi, Farin Kamangar, Neal D Freedman, Christian C Abnet, Paul Brennan, Reza Malekzadeh
BACKGROUND: There is limited information about the hazards of cigarettes, smokeless tobacco and waterpipe in the Middle East. The aim of this study was to determine the association between different types of tobacco use and earlier death in the Golestan Cohort Study. METHODS: The Study includes 50 045 adults (aged 40-75 years) from north eastern Iran. The baseline questionnaire (2004-2008) assessed information about use of cigarettes, chewing tobacco (nass) and waterpipe...
November 21, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27853327/the-effects-of-maternal-opium-abuse-on-fetal-heart-rate-using-non-stress-test
#19
Fatemeh Keikha, Fahimeh Ghotbizadeh Vahdani, Sahar Latifi
BACKGROUND: Opium is one of the most commonly abused opiates in developing countries including Iran. Considering the importance of maternal health on the newborn, we aimed to assess the effect of opium abuse on fetal heart rate (FHR) characteristics in a sample of pregnant women in Zahedan, Southeast Iran. METHODS: This cross-sectional study was done on 100 pregnant women referring to Ali-Ibn-Abi Talib Hospital in Zahedan, during 2011-2013. The participants were divided into two groups comprising of opium abusers and healthy individuals...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27844021/no-association-between-gstm1-and-gstt1-genetic-polymorphisms-and-susceptibility-to-opium-sap%C3%A2-dependence
#20
Khyber Saify, Mohammad Rashid Khalighinasab, Mostafa Saadat
Glutathione S-transferases (GSTs; EC: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase II metabolic isozymes. Genes encoding GSTM1 (OMIM: 138350), and GSTT1 (OMIM: 600436) are members of class mu and theta, respectively. The most common polymorphism in the GSTM1 is a deletion of the whole GSTM1 gene with a lack of enzyme activity. A homozygous deletion in the GSTT1 has also been reported (null genotypes of GSTT1). The aim of the present study was to investigate the association between GSTM1 and GSTT1 polymorphisms and risk of dependency to opium sap...
March 2016: Molecular Biology Research Communications
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