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https://www.readbyqxmd.com/read/27896238/retroperitoneal-fibrosis-due-to-opium-abuse-a-case-series-and-literature-review
#1
Mohammad Ali Mohammadzadeh Rezaei, Alireza Akhavan Rezayat, Shima Ardalan
Retroperitoneal fibrosis (RPF) is a rare condition with an unclear etiology, presenting with the development of aberrant chronic nonspecific fibroinflammatory tissue in the retroperitoneal space, which can result in entrapment and obstruction of the retroperitoneal structures. RPF is a subtype of chronic periaortitis, and can be divided into two types: primary (or idiopathic) and secondary. RPF is usually idiopathic, but can also be secondary to malignancies, certain drugs, infections, surgery, and trauma. The systemic clinical manifestations are nonspecific and include low-grade fever, fatigue, anorexia, weight loss, and myalgia...
November 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27885167/mortality-from-respiratory-diseases-associated-with-opium-use-a-population-based-cohort-study
#2
Atieh Rahmati, Ramin Shakeri, Hooman Khademi, Hossein Poutschi, Akram Pourshams, Arash Etemadi, Masoud Khoshnia, Amir Ali Sohrabpour, Ali Aliasgari, Elham Jafari, Farhad Islami, Shahryar Semnani, Abdolsamad Gharravi, Christian C Abnet, Paul D P Pharoah, Paul Brennan, Paolo Boffetta, Sanford M Dawsey, Reza Malekzadeh, Farin Kamangar
BACKGROUND: Recent studies have suggested that opium use may increase mortality from cancer and cardiovascular diseases. However, no comprehensive study of opium use and mortality from respiratory diseases has been published. We aimed to study the association between opium use and mortality from respiratory disease using prospectively collected data. METHODS: We used data from the Golestan Cohort Study, a prospective cohort study in northeastern Iran, with detailed, validated data on opium use and several other exposures...
November 24, 2016: Thorax
https://www.readbyqxmd.com/read/27882209/marketed-new-drug-delivery-systems-for-opioid-agonists-antagonists-administration-a-rapid-overview
#3
REVIEW
Hoda Soltani, Abbas Pardakhty
Novel drug delivery systems for controlled-release of opioid agonists as a long time painkillers or opioid antagonists for opium, heroin, and alcohol addiction are under development or in clinical use today. In this article, the field of "new drug delivery systems" is momentarily reviewed from the viewpoint of the marketed opioid agonists/antagonists dosage forms today.
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27882205/sleep-disorders-in-methadone-maintenance-treatment-volunteers-and-opium-dependent-patients
#4
Habibolah Khazaie, Farid Najafi, Mohammad Rasoul Ghadami, Atena Azami, Marzieh Nasouri, Masoud Tahmasian, Behnam Khaledi-Paveh
BACKGROUND: The relationship between substance use and sleep is bidirectional. Substance use directly causessleep disturbances, and sleep problems are a critical factor in substance-use relapse. METHODS: This study evaluated sleep disorders in 65 methadone maintenance treatment (MMT) patients, and61 opium-dependent patients who did not receive any treatment between September 2011 and July 2012 inKermanshah, Iran. Both groups filled out the Pittsburgh Sleep Quality Index (PSQI) and Global SleepAssessment Questionnaire (GSAQ)...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27882204/comparison-of-quantitative-and-qualitative-dermatoglyphic-characteristics-of-opium-addicts-with-healthy-individuals
#5
Omid Mehrpour, Ardeshir Sheikhazadi, Afsoon Barzegar, Afzal Husein, Claudia Malic, Elham Sheikhazadi, Seyed Hossein Saberi-Anary
BACKGROUND: Recreational drugs have a significant impact on the lives of drug users, their close families andfriends, as well as their society. Social, psychological, biological, and genetic factors could make a personmore prone to using recreational drugs. Finger and A-B ridges (dermatoglyphics) are formed during the firstand second trimesters of fetal development, under the influence of environmental and genetic factors. Theaim of our study was to investigate and evaluate a possible link between dermatoglyphics and opium usage...
April 2016: Addiction & Health
https://www.readbyqxmd.com/read/27872345/hazards-of-cigarettes-smokeless-tobacco-and-waterpipe-in-a-middle-eastern-population-a-cohort-study-of-50%C3%A2-000-individuals-from-iran
#6
Arash Etemadi, Hooman Khademi, Farin Kamangar, Neal D Freedman, Christian C Abnet, Paul Brennan, Reza Malekzadeh
BACKGROUND: There is limited information about the hazards of cigarettes, smokeless tobacco and waterpipe in the Middle East. The aim of this study was to determine the association between different types of tobacco use and earlier death in the Golestan Cohort Study. METHODS: The Study includes 50 045 adults (aged 40-75 years) from north eastern Iran. The baseline questionnaire (2004-2008) assessed information about use of cigarettes, chewing tobacco (nass) and waterpipe...
November 21, 2016: Tobacco Control
https://www.readbyqxmd.com/read/27853327/the-effects-of-maternal-opium-abuse-on-fetal-heart-rate-using-non-stress-test
#7
Fatemeh Keikha, Fahimeh Ghotbizadeh Vahdani, Sahar Latifi
BACKGROUND: Opium is one of the most commonly abused opiates in developing countries including Iran. Considering the importance of maternal health on the newborn, we aimed to assess the effect of opium abuse on fetal heart rate (FHR) characteristics in a sample of pregnant women in Zahedan, Southeast Iran. METHODS: This cross-sectional study was done on 100 pregnant women referring to Ali-Ibn-Abi Talib Hospital in Zahedan, during 2011-2013. The participants were divided into two groups comprising of opium abusers and healthy individuals...
November 2016: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27844021/no-association-between-gstm1-and-gstt1-genetic-polymorphisms-and-susceptibility-to-opium-sap%C3%A2-dependence
#8
Khyber Saify, Mohammad Rashid Khalighinasab, Mostafa Saadat
Glutathione S-transferases (GSTs; EC: 2.5.1.18) are a ubiquitous family of eukaryotic and prokaryotic phase II metabolic isozymes. Genes encoding GSTM1 (OMIM: 138350), and GSTT1 (OMIM: 600436) are members of class mu and theta, respectively. The most common polymorphism in the GSTM1 is a deletion of the whole GSTM1 gene with a lack of enzyme activity. A homozygous deletion in the GSTT1 has also been reported (null genotypes of GSTT1). The aim of the present study was to investigate the association between GSTM1 and GSTT1 polymorphisms and risk of dependency to opium sap...
March 2016: Molecular Biology Research Communications
https://www.readbyqxmd.com/read/27830833/noscapine-targets-egfr-p-tyr1068-to-suppress-the-proliferation-and-invasion-of-mg63-cells
#9
Ming He, Linlin Jiang, Zhaozhou Ren, Guangbin Wang, Jiashi Wang
Osteosarcoma, the most common primary malignant bone tumor, usually arises in the metaphysis of long bones. Amplification and mutation of the epidermal growth factor receptor (EGFR) gene represent signature genetic abnormalities encountered in osteosarcoma. Noscapine is a benzylisoquinoline alkaloid derived from the opium poppy Papaver somniferum. Recently several studies have suggested its anti-cancer effect in melanoma, ovarian cancer, gliomas, breast cancer, lung cancer, and colon cancer. However, the underlying molecular mechanism for its anti-cancer effect still remains unclear...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27818962/the-frequency-of-high-risk-behaviors-among-iranian-college-students-using-indirect-methods-network-scale-up-and-crosswise-model
#10
Yasan Kazemzadeh, Mostafa Shokoohi, Mohammad Reza Baneshi, Ali Akbar Haghdoost
BACKGROUND: Since the direct questions usually underestimate the frequency of sensitive behaviors, indirect methods can be used to estimate the frequency of some risky behaviors such as illicit drug use, sexual behaviors especially where these behaviors are highly stigmatized. OBJECTIVES: In the current study, we indirectly estimated the prevalence of some risky behaviors among college students using two indirect methods: network scale-up (NSU) and crosswise model (CM)...
September 2016: International Journal of High Risk Behaviors & Addiction
https://www.readbyqxmd.com/read/27803011/chronic-lead-poisoning-in-an-iranian-opium-smoker-resident-in-london
#11
Alex Azizi, Katie Ferguson, Sam Dluzewski, Tajammul Hussain, Martin Klein
A 46-year-old man of Iranian origin presented with a 4-day history of colicky abdominal pain and absolute constipation on a background of several weeks of irritability and malaise. He had smoked 10 g of opium per week for a year and a half. On examination, he had diffuse abdominal tenderness and faecal loading. This was cleared, but the abdominal pain, nausea and vomiting persisted. He had extravascular haemolytic anaemia with punctate basophilic stippling on blood film. The patient's serum lead concentration was substantially elevated and he perhaps demonstrated Burton's line...
November 1, 2016: BMJ Case Reports
https://www.readbyqxmd.com/read/27798031/the-environmental-footprint-of-morphine-a-life-cycle-assessment-from-opium-poppy-farming-to-the-packaged-drug
#12
Scott McAlister, Yanjun Ou, Elise Neff, Karen Hapgood, David Story, Philip Mealey, Forbes McGain
OBJECTIVE: To examine the environmental life cycle from poppy farming through to production of 100 mg in 100 mL of intravenous morphine (standard infusion bag). DESIGN: 'Cradle-to-grave' process-based life cycle assessment (observational). SETTINGS: Australian opium poppy farms, and facilities for pelletising, manufacturing morphine, and sterilising and packaging bags of morphine. MAIN OUTCOME MEASURES: The environmental effects (eg, CO2 equivalent ('CO2 e') emissions and water use) of producing 100 mg of morphine...
October 21, 2016: BMJ Open
https://www.readbyqxmd.com/read/27790356/moderate-hypothermia-and-its-effects-in-reducing-the-applied-dose-of-anesthetics-for-patients-with-opium-dependence-in-cardiac-surgery-a-randomized-controlled-trial
#13
Reza Jalaian Taghadomi, Ebrahim Golmakani, Kambiz Alizadeh, Behrooz Mottahedi, Ali Rahdari, Shima Sheybani
BACKGROUND: An increasing number of patients addicted to opium are experiencing awareness during coronary artery bypass surgery (CABG) as a result of tolerance to anesthetics. OBJECTIVES: This research was primarily intended to determine the potential diminishing effects of moderate hypothermia on anesthetic dosage and recall of anesthesia during the procedure. METHODS: In this double-blind randomized controlled trial, a total of 80 CABG candidates with known addiction to opium were divided into two groups: one normothermic (N) and the other moderately hypothermic (H), both undergoing induction as well as close monitoring from September 2014 to January 2016...
September 2016: Electronic Physician
https://www.readbyqxmd.com/read/27790151/the-impact-of-opium-consumption-on-blood-glucose-serum-lipids-and-blood-pressure-and-related-mechanisms
#14
REVIEW
Hamid Najafipour, Ahmad Beik
Aim: Substance abuse has become a universal crisis in our modern age. Among illegal substances, opium and its derivatives have been ranked second in terms of usage after cannabis in the world. In many Asian regions, the use of opium enjoys a high social acceptance; hence, some common people and even medical practitioners believe that opium lowers blood glucose and pressure and treat dyslipidemia. How much this belief is scientifically justified? Method: The results of available studies on both humans and animals searched in different search engines up to mid-2016 were integrated (78 articles)...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27780655/lessons-in-ambivalence-the-shanghai-municipal-council-s-opium-policies-1906-1917
#15
Yong-An Zhang, Yilun Du
BACKGROUND: Shanghai was considered to be a "capital of opium" in modern China, hence the history of opium in the city has received significant attention. In the Shanghai International Settlement, where Chinese and foreigners lived as neighbours, drugs were considered by the administration as both "trouble maker", and important financial resource. This paper explores how the Shanghai Municipal Council (SMC), the most senior governing body in the settlement, used its position to maximize political and economic profit from the trade and consumption of opium...
October 22, 2016: International Journal on Drug Policy
https://www.readbyqxmd.com/read/27777381/a-new-antiproliferative-noscapine-analogue-chemical-synthesis-and-biological-evaluation
#16
Peter E Ghaly, Rabab M Abou El-Magd, Cassandra D M Churchill, Jack A Tuszynski, F G West
Noscapine, a naturally occurring opium alkaloid, is a widely used antitussive medication. Noscapine has low toxicity and recently it was also found to possess cytotoxic activity which led to the development of many noscapine analogues. In this paper we report on the synthesis and testing of a novel noscapine analogue. Cytotoxicity was assessed by MTT colorimetric assay using SKBR-3 and paclitaxel-resistant SKBR-3 breast cancer cell lines using different concentrations for both noscapine and the novel compound...
June 28, 2016: Oncotarget
https://www.readbyqxmd.com/read/27761334/the-ethnobotany-of-psychoactive-plant-use-a-phylogenetic-perspective
#17
Nashmiah Aid Alrashedy, Jeanmaire Molina
Psychoactive plants contain chemicals that presumably evolved as allelochemicals but target certain neuronal receptors when consumed by humans, altering perception, emotion and cognition. These plants have been used since ancient times as medicines and in the context of religious rituals for their various psychoactive effects (e.g., as hallucinogens, stimulants, sedatives). The ubiquity of psychoactive plants in various cultures motivates investigation of the commonalities among these plants, in which a phylogenetic framework may be insightful...
2016: PeerJ
https://www.readbyqxmd.com/read/27755956/induction-of-apoptosis-by-opium-in-some-tumor-cell-lines
#18
M Khaleghi, A Farsinejad, S Dabiri, G Asadikaram
The current study is aimed at investigation of the opium effects on the apoptosis of different cell lines in culture medium and compares such effects with one another. The study is carried out on over 8 cell lines (AA8, AGS, Hela, HepG2, MCF7, N2a, PC12, WEHI). A 2.86 x 10-4 g/ml opium concentration was prepared and added to the culture medium of the cell lines for 48 hours. Cytotoxicity was tested by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay. The apoptotic effect of opium on the cell lines was analyzed by Annexin-PI test...
September 30, 2016: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/27752985/suspected-adulteration-of-commercial-kratom-products-with-7-hydroxymitragynine
#19
Alicia G Lydecker, Abhisheak Sharma, Christopher R McCurdy, Bonnie A Avery, Kavita M Babu, Edward W Boyer
INTRODUCTION: Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has been used for centuries for its stimulant and opium-like effects. Mitragynine and 7-hydroxymitragynine, exclusive to M. speciosa, are the alkaloids primary responsible for Kratom's biologic and psychoactive profile, and likely contribute to its problematic use. We purchased several commercially available Kratom analogs for analysis and through our results, present evidence of probable adulteration with the highly potent and addictive plant alkaloid, 7-hydroxymitragynine...
December 2016: Journal of Medical Toxicology: Official Journal of the American College of Medical Toxicology
https://www.readbyqxmd.com/read/27740713/tincture-of-opium-for-treating-opioid-dependence-a-systematic-review-of-safety-and-efficacy
#20
Mohammadali Nikoo, Nooshin Nikoo, Sanam Javid, Afshar Amiri, Marc Vogel, Fiona Choi, Amir Ali Sepehry, Amir Hooshang Bagheri Valoojerdi, Kerry Jang, Christian Schütz, Shahin Akhondzadeh, Michael Krausz
BACKGROUND AND AIMS: Recently, there has been a growing interest in using Opium Tincture (OT) for treating opioid dependence in certain regions. We aimed to assess the evidence on its safety and efficacy for this indication. METHODS: We searched several databases (CENTRAL, Medline, EMBASE, Web of Science, PsychINFO, ProQuest Dissertation & Theses Database, Iran Medex, clinicaltrials.gov, and who.int/trialsearch) with no language or publication date limitations. Two reviewers selected Randomized Controlled Trials (RCT), cohort /case-control/ cross-sectional studies and case-series on safety or efficacy of OT for treating opioid dependence and then extracted reported measures of mentioned outcomes from selected studies...
October 14, 2016: Addiction
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