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https://www.readbyqxmd.com/read/29220602/an-observational-study-of-treatment-seeking-users-of-natural-opiates-from-india
#1
Arpit Parmar, Vaibhav Patil, Siddharth Sarkar, Ravindra Rao
BACKGROUND: The type of opioid used influences the severity and complications experienced. Natural opiates (opium and poppy husk) use is a socio-culturally accepted phenomenon reported in India. However, studies on their profile, quality of life, and addiction severity are limited. OBJECTIVES: The objective of this cross-sectional, observational study was to assess the socio-demographic profile, clinical profile, addiction severity, and quality of life of treatment-seeking natural opiate users...
December 8, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/29190268/synthetic-cannabinoid-and-mitragynine-exposure-of-law-enforcement-agents-during-the-raid-of-an-illegal-laboratory-nevada-2014
#2
Loren Tapp, Jessica G Ramsey, Anita Wen, Roy Gerona
Synthetic cannabinoids (SCs), commonly known by the street name "Spice," are designer drugs of abuse that mimic the psychoactive effects of marijuana. Intentional SC use has resulted in multiple toxicities (1,2), but little is known about occupational SC exposure. After a federal agency's law enforcement personnel in Nevada reported irritability and feeling "high" after raiding illegal SC laboratories and processing seized SCs, a request for a health hazard evaluation was made by the agency to CDC's National Institute for Occupational Safety and Health (NIOSH) in 2014 to evaluate agents' occupational SC exposures...
December 1, 2017: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/29184570/opium-an-important-risk-factor-for-deep-vein-thrombosis-patients
#3
Toba Kazemi, Mahsa Qasemi, Morteza Hajihosseini
No abstract text is available yet for this article.
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/29134077/investigation-of-the-acid-base-behaviour-of-the-opium-alkaloid-thebaine-in-lc-esi-ms-mobile-phase-by-nmr-spectroscopy
#4
Michelle G Carlin, John R Dean, Jonathan L Bookham, Justin J B Perry
As part of a research programme to establish an analytical method for the simultaneous detection of the five major opium alkaloids in poppy seeds by liquid chromatography-electrospray ionization-mass spectrometry (LC-ESI-MS) it was discovered that the inclusion of thebaine produced two peaks for the same compound. This was in contrast to the effective simultaneous detection, by LC-ESI-MS, of morphine, codeine, papaverine and noscapine. The presence of these two peaks for thebaine was investigated using nuclear magnetic resonance spectroscopy with deuterated solvents to emulate the mobile phase conditions experienced...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29130600/opioid-dependence-and-pregnancy-in-early-twentieth-century-america
#5
Nathan Tauger
BACKGROUND AND AIMS: Research on Neonatal Abstinence Syndrome has prompted discussion over how to ensure best outcomes for pregnant women who use drugs and for drug-dependent newborns. Before Neonatal Abstinence Syndrome and the 1980s panic of "crack babies," turn-of-the-century American medical journals discussed infants born to drug-using mothers. This paper aimed to determine whether women who used drugs while pregnant in early twentieth-century America were subject to the stigma many face today...
November 11, 2017: Addiction
https://www.readbyqxmd.com/read/29121712/epidemiologic-incidence-of-rhabdomyolysis-in-opioid-overdose-in-icu-of-poisoning-center-in-iran-2014
#6
Babak Khoshideh, Mohammad Arefi, Mazaher Ghorbani, Samaneh Akbarpour, Fatemeh Taghizadeh
Objectives: The aim of this study is to investigate the clinical, demographical characteristics and some laboratory findings of hospitalized patients with acute opioid toxicity and rhabdomyolysis. Methods: In this cross-sectional study, 354 hospitalized patients were investigated at Baharloo Educational Hospital in Tehran, with acute illicit drug toxicity in 2014. Data was collected by an investigator-made check lists. The collected data and variations (such as mortality rate, demographic data, and renal function tests as well as serum biochemical elements) were analyzed by descriptive statistics and x-square test...
November 8, 2017: Epidemiology and Health
https://www.readbyqxmd.com/read/29067412/treatment-of-the-opium-neurosis-by-stephen-lett-m-d-ont-canada
#7
(no author information available yet)
No abstract text is available yet for this article.
October 24, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29037712/straightforward-analytical-method-to-determine-opium-alkaloids-in-poppy-seeds-and-bakery-products
#8
Patricia López, Diana P K H Pereboom-de Fauw, Patrick P J Mulder, Martien Spanjer, Joyce de Stoppelaar, Hans G J Mol, Monique de Nijs
A straightforward method to determine the content of six opium alkaloids (morphine, codeine, thebaine, noscapine, papaverine and narceine) in poppy seeds and bakery products was developed and validated down to a limit of quantification (LOQ) of 0.1mg/kg. The method was based on extraction with acetonitrile/water/formic acid, ten-fold dilution and analysis by LC-MS/MS using a pH 10 carbonate buffer. The method was applied for the analysis of 41 samples collected in 2015 in the Netherlands and Germany. All samples contained morphine ranging from 0...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29035158/humanizing-folk-devils-using-ethnography
#9
Peter L Myers
The sociological concepts of the "moral panic" and the deviant "folk devil" apply to the drug panics in the United States over methamphetamine, heroin, and crack cocaine. Mothers or pregnant women who smoke crack cocaine, and their babies, are assigned exaggerated "demonic" attributes that result in stigma and societal rejection. Otherwise, ethnographic studies of drug users demonstrate realities that are other than what might be considered were one to merely look at their use and the consequences. These considerations are examined with respect to the image of folk devils, methadone program attendees, smokers of "blunts," opium den habitués, and others grouped together as negative influences as a result of their drug habits...
October 16, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29026499/comparison-between-homocysteine-fibrinogen-pt-ptt-inr-and-crp-in-male-smokers-with-without-addiction-to-opium
#10
Nahid Azdaki, Mahmood Zardast, Gholamreza Anani-Sarab, Hamid Abdorrazaghnaejad, Mohammad Reza Ghasemian, Amin Saburi
BACKGROUND: Regarding the limited studies about effects of addiction on coagulation factors as a risk factor for increasing coagulation, and its relation to coronary artery disease, we decided to investigate the effect of opium on inflammatory and coagulation factors in a controlled setting. METHODS: This case-control study was performed using two groups of smoking males addicted to opium (27 cases) and not addicted to opium (27 cases). After collecting demographic data, venous blood samples were gathered and sent to laboratory for measuring homocysteine, fibrinogen, prothrombin time (PT), partial thromboplastin time (PTT), International Normalized Ratio (INR), and C-reactive protein (CRP) quantity...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29026498/a-case-control-study-of-comparison-of-plasma-levels-of-matrix-metalloproteinase-9-in-inhaled-opium-addicts-and-clinically-healthy-persons
#11
Maryam Amizadeh, Shahryar Dabiri, Armin Javedan, Ali Eftekharian, Aliasghar Arabi-Mianroodi
BACKGROUND: Metalloproteinase-9 exists in the basement membrane of normal tissues and is a major factor in cancer invasion and lymphatic metastasis. Smoking has been reported to increase the metalloproteinase level, but the role of opium consumption in metalloproteinase level has not yet been examined. The current research intended to examine the impacts of opium consumption on the serum levels of metalloproteinase. METHODS: This case-control research was conducted in Kerman (in the southeast of Iran), after getting medical approve by the ethics committee...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/29026497/methadone-replacement-therapy-and-sexual-disorders-among-opium-dependent-iranian-men-a-meta-analysis-study
#12
Masoudeh Babakhanian, Ali Akbar Haghdoost, Mahdi Afshari, Fatemeh Taghizadeh, Mahmood Moosazadeh
BACKGROUND: Evaluation of sexual disorders among persons receiving methadone replacement therapy is of great importance, because these problems may lead to non-compliance and relapse. This study aimed to estimate the effect of methadone maintenance therapy (MMT) on sexual function among addicted Iranian men using met-analysis. METHODS: Investigating the available data banks, relevant studies were identified. After exclusion of duplicates, irrelevant papers and low quality articles, eligible papers were entered into the meta-analysis...
January 2017: Addiction & Health
https://www.readbyqxmd.com/read/28990740/schedules-of-controlled-substances-removal-of-naldemedine-from-control-final-rule
#13
(no author information available yet)
With the issuance of this final rule, the Drug Enforcement Administration removes the substance naldemedine (4R,4aS,7aR,12bS)-3-(cyclopropylmethyl)-4a,7,9-trihydroxy-N-(2-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-2-yl)-2,3,4,4a,5,7a-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-6-carboxamide) including its salts from the schedules of the Controlled Substances Act. Prior to the effective date of this rule, naldemedine was a schedule II controlled substance because it can be derived from opium alkaloids. This action removes the regulatory controls and administrative, civil, and criminal sanctions applicable to controlled substances, including those specific to schedule II controlled substances, on persons who handle (manufacture, distribute, reverse distribute, dispense, conduct research, import, export, or conduct chemical analysis) or propose to handle naldemedine...
September 29, 2017: Federal Register
https://www.readbyqxmd.com/read/28982369/lead-poisoning-among-opium-users-in-iran-an-emerging-health-hazard
#14
Mohammad Mahdi Hayatbakhsh, Zohreh Oghabian, Elvira Conlon, Samaneh Nakhaee, Ali Reza Amirabadizadeh, Mohammad Javad Zahedi, Sodief Darvish Moghadam, Bighan Ahmadi, Somayeh Soroush, Jan Aaseth, Omid Mehrpour
BACKGROUND: Lead (Pb) poisoning among people using opium has been an increasing problem in Iran. The present study highlights the clinical effects of lead toxicity associated with opium use in Iran, Kerman province. METHODS: Between January 2016 and June 2016, patients with signs and symptoms of Pb poisoning were questioned to assess whether they had a history of opium dependency. In total, 249 patients were enrolled onto this cross-sectional study, all were opium dependent...
October 5, 2017: Substance Abuse Treatment, Prevention, and Policy
https://www.readbyqxmd.com/read/28975072/a-comparison-of-the-sociodemographic-and-clinical-characteristics-of-patients-referring-to-a-pain-clinic-with-subacute-and-chronic-pain
#15
Seyed Masoud Hashemi, Ramin Rohanifar, Rasoul Azarfarin, Seyed Sajjad Razavi, Sirous Momenzadeh
OBJECTIVES: The aim of the present study was to assess and compare the sociodemographic characteristics and clinical features of patients referring to a university hospital's pain clinic with chronic ( ≥ 12 weeks) and subacute pain ( < 12 weeks). METHODS: In this cross-sectional study, 426 patients were included. Demographic variables including education level, marital and employment status, and risk factors such as obesity, diabetes mellitus, hypertension, cigarette smoking, and opium addiction were recorded...
December 2016: Anesthesiology and Pain Medicine
https://www.readbyqxmd.com/read/28973785/quantification-of-morphine-codeine-and-thebaine-in-home-brewed-poppy-seed-tea-by-lc-ms-ms
#16
Deborah Powers, Stephen Erickson, Madeleine J Swortwood
Recently, medical examiners reported two cases of a 21-year-old male and 24-year-old male with high amounts of morphine in their blood at autopsy. It was suspected that the decedents ingested lethal amounts of morphine from home-brewed poppy seed tea. No studies to date have investigated opium alkaloid content extracted from poppy seeds by home-brewing methods. Various poppy seed products were purchased from online sources and extracted with four home-brewing methods representative of recipes found on drug user forums...
October 3, 2017: Journal of Forensic Sciences
https://www.readbyqxmd.com/read/28944941/proconvulsant-effect-of-papaverine-on-penicillin-induced-epileptiform-activity-in-rats
#17
Abdullah Hilmi Marangoz, Suleyman Emre Kocacan, Aydın Him, Enis Kuruoglu, Cengiz Cokluk, Cafer Marangoz
AIM: Papaverine is a vasodilator agent that is an opium alkaloid. It exhibits its effects by inhibiting phosphodiesterase enzyme. Papaverine administration is widely used to avoid symptomatic vasospasm after subarachnoid hemorrhage. We aim in this research to study the effects of papaverine on the epileptic discharges stimulated by penicillin. MATERIAL AND METHODS: Adult female Wistar rats (220±30 g) were included in this research (n=30). Rats were anesthetized with urethane (1...
July 11, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28936080/maintainence-treatment-of-opioid-dependence-with-tramadol
#18
Siddharth Sarkar, Mohit Varshney, Vaibhav Patil, Rakesh Lal
BACKGROUND: Although tramadol has been used in the management of acute withdrawal in patients with opioid dependence, its use for maintenance treatment as a harm reduction approach has not been assessed systematically. This case series describes patients with opioid dependence who were treated with tramadol for long-term maintenance. METHODS: Patients with opioid dependence who received treatment at the National Drug Dependence Treatment Centre of All India Institute of Medical Sciences, New Delhi, were included in the study...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28924278/main-predictors-for-repetition-of-suicidal-behaviour-among-women-referred-to-a-single-public-sector-tertiary-care-hospital-in-iran
#19
Babak Mostafazadeh, Esmaeil Farzaneh
OBJECTIVE: To assess the main predictors for repetition of suicidal behaviour among women. METHODS: This cross-sectional study was conducted at Loghman Hakim Hospital, Tehran, Iran, in 2014, and comprised women patients. The patients were divided into two groups, i.e. women repeating suicide and women without repeating suicide. Data was collected through a checklist and then analysed with SPSS 20. RESULTS: Of the 300 women, 121(40.3%) repeated suicide and 179(59...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28921677/clinical-profile-of-hepatitis-c-virus-infection-in-a-developing-country-india
#20
Ramit Mahajan, Vandana Midha, Omesh Goyal, Varun Mehta, Vikram Narang, Kirandeep Kaur, Arshdeep Singh, Dharmatma Singh, Rishu Bhanot, Ajit Sood
BACKGROUND: The epidemiology and clinical profile of hepatitis C virus (HCV) varies worldwide and data from developing countries is sparse. AIMS: To study the clinical profile of HCV infection in a developing country in South East Asia (India). METHODS: This observational study assessed patient demographics, viral characteristics, risk factors for virus acquisition and disease characteristics in HCV patients diagnosed between January 2004 and December 2015...
September 18, 2017: Journal of Gastroenterology and Hepatology
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