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https://www.readbyqxmd.com/read/29909580/lonie-r-salkowski-and-tanya-w-moseley-clinical-breast-tomosynthesis-a-case-based-approach-thieme-medical-publishers-new-york-2017-isbn-978-1-62623-208-2
#1
Pasqualina Buonomano, Luigi Mansi
No abstract text is available yet for this article.
June 16, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29909577/population-pharmacokinetic-model-for-tumescent-lidocaine-in-women-undergoing-breast-cancer-surgery
#2
Camille Riff, Aurélie Bourgoin, Amelie Marsot, Laurent Allanioux, Marc Leone, Olivier Blin, Romain Guilhaumou
PURPOSE: Tumescent lidocaine anesthesia (TLA) is an opportunity to perform mastectomy for breast cancer without general anesthesia in elderly women. Few reports are available on the pharmacokinetics of lidocaine in a context of TLA during a unilateral mastectomy. The aim of this study was to describe lidocaine pharmacokinetics in elderly women undergoing breast cancer surgery after TLA and to explore the risk of the toxicity of this technique. METHODS: A prospective study was conducted to examine the pharmacokinetics of lidocaine in women undergoing TLA...
June 16, 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29909568/association-between-chek2-1100delc-and-breast-cancer-a-systematic-review-and-meta-analysis
#3
REVIEW
Mingming Liang, Yun Zhang, Chenyu Sun, Feras Kamel Rizeq, Min Min, Tingting Shi, Yehuan Sun
INTRODUCTION: The association between the checkpoint kinase 2*1100delC (CHEK2*1100delC) and breast cancer has been extensively explored. OBJECTIVE: In light of the recent publication of studies on these specific findings, particularly regarding male patients with breast cancer, we performed an updated meta-analysis to investigate a more reliable estimate. METHODS: This meta-analysis included 26 published studies selected in a search of electronic databases up to January 2018, including 118,735 breast cancer cases and 195,807 controls...
June 16, 2018: Molecular Diagnosis & Therapy
https://www.readbyqxmd.com/read/29909564/organized-screening-detects-breast-cancer-at-earlier-stage-regardless-of-molecular-phenotype
#4
Claire M B Holloway, Li Jiang, Marlo Whitehead, Jennifer M Racz, Patti A Groome
PURPOSE: Mortality reduction attributable to organized breast screening is modest. Screening may be less effective at detecting more aggressive cancers at an earlier stage. This study was conducted to determine the relative efficacy of screening mammography to detect cancers at an earlier stage by molecular phenotype. METHODS: We identified 2882 women with primary invasive breast cancer diagnosed between January 1, 2008 and December 31, 2012 and who had a mammogram through the Ontario Breast Screening Program in the 28 months before diagnosis...
June 16, 2018: Journal of Cancer Research and Clinical Oncology
https://www.readbyqxmd.com/read/29909352/the-role-of-milk-fat-globule-membranes-in-behavior-and-cognitive-function-using-a-suckling-rat-pup-supplementation-model
#5
Lauren R Brink, Bo Lönnerdal
Milk fat globule membranes (MFGM) surround droplets delivering lipids to the breast-fed infant and are enriched with glycoproteins upon exocytosis out of the mammary cell. MFGM is typically removed during processing of cow milk for the manufacture of infant formula. Recent clinical trials have found that formula supplemented with bovine MFGM improved cognition. Here, we aimed to explore the mechanisms behind this improved developmental outcome. Sprague-Dawley rats were bred, and their litters were manipulated to either 10 pups to represent normal growth (N) or 16 pups to represent restricted growth (R) per dam...
May 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29909329/disentangling-the-relative-role-of-climate-change-on-tree-growth-in-an-extreme-mediterranean-environment
#6
Jaime Madrigal-González, Enrique Andivia, Miguel A Zavala, Markus Stoffel, Joaquín Calatayud, Raúl Sánchez-Salguero, Juan Ballesteros-Cánovas
Climate change can impair ecosystem functions and services in extensive dry forests worldwide. However, attribution of climate change impacts on tree growth and forest productivity is challenging due to multiple inter-annual patterns of climatic variability associated with atmospheric and oceanic circulations. Moreover, growth responses to rising atmospheric CO2 , namely carbon fertilization, as well as size ontogenetic changes can obscure the climate change signature as well. Here we apply Structural Equation Models (SEM) to investigate the relative role of climate change on tree growth in an extreme Mediterranean environment (i...
June 14, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29909282/impact-of-blade-tenderization-marinade-and-cooking-temperature-on-oral-comfort-when-eating-meat-in-an-elderly-population
#7
Mathilde Vandenberghe-Descamps, Claire Sulmont-Rossé, Chantal Septier, Claire Follot, Gilles Feron, Hélène Labouré
Several studies demonstrated that oral health impairment, such as tooth loss or a decrease in salivary flow might lead elderly people to reduce their meat intake. The present study assessed the impact of culinary processes liable to improve meat texture and smooth down meat oral processing, in order to fulfil the oral capacities of elderly people. Four culinary processes were selected: cooking bag, blade tenderizer, marinade and low-temperature cooking. A panel of 40 elderly participants with good and poor dental status were asked to assess 5 chicken breast samples, 5 roast beef samples and 4 beefsteak samples prepared according to different process conditions by using an "oral comfort" questionnaire...
June 5, 2018: Meat Science
https://www.readbyqxmd.com/read/29909259/survival-benefit-of-surgical-removal-of-primary-tumor-in-patients-with-stage-iv-breast-cancer
#8
Hye Jin Kim, Eunyoung Kang, Jee Hyun Kim, Se Hyun Kim, Yu Jung Kim, In Ah Kim, Keun-Yong Eom, Su Min Chae, Kyu Min Kang, Eun Kyu Kim, Sung-Won Kim
BACKGROUND: Several studies have suggested that primary tumor removal improved overall survival for patients with stage IV breast cancer. However, the survival benefit of local treatment remains controversial. The purpose of the present study was to determine whether surgical removal of the primary tumor provides survival benefits to patients with stage IV breast cancer. PATIENTS AND METHODS: We retrospectively reviewed the medical records of 155 patients with an initial diagnosis of stage IV breast cancer at Seoul National University Bundang Hospital from 2003 to 2014...
May 28, 2018: Clinical Breast Cancer
https://www.readbyqxmd.com/read/29909120/integrated-in-silico-in-vitro-strategy-for-screening-of-some-traditional-egyptian-plants-for-human-aromatase-inhibitors
#9
Hend M Dawood, Reham S Ibrahim, Eman Shawky, Hala M A Hammoda, Aly M Metwally
ETHNOPHARMACOLOGICAL RELEVANCE: Aromatase enzyme (CYP19) is widely known as a critical target protein for treating hormone-dependent breast cancer. Natural products from traditional medicinal plants continue to be an active source of aromatase inhibitors. Meanwhile, high cost of experimental work and low hit rate associated with HTS have stimulated the implementation of in-silico virtual screening to resolve these pitfalls, where coupling of both classical wet lab procedure and VS may offer a more deepened access to bioactive compounds with less work and time waste...
June 14, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29909105/rationale-and-design-of-the-strain-surveillance-of-chemotherapy-for-improving-cardiovascular-outcomes-succour-trial
#10
Tomoko Negishi, Paaladinesh Thavendiranathan, Kazuaki Negishi, Thomas H Marwick
OBJECTIVES: This study sought to evaluate the hypothesis that global longitudinal strain (GLS) guidance of cardioprotective therapy would improve cardiac function of at-risk patients undergoing potentially cardiotoxic chemotherapy, compared with usual care. BACKGROUND: The conventional criteria for diagnosis of chemotherapy-related cardiac dysfunction (CTRCD) are dependent on the recognition of heart failure symptoms and/or changes in left ventricular ejection fraction...
June 8, 2018: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29909039/integrin-%C3%AE-6-and-egfr-signaling-converge-at-mechanosensitive-calpain-2
#11
A D Schwartz, C L Hall, L E Barney, C C Babbitt, S R Peyton
Cells sense and respond to mechanical cues from the extracellular matrix (ECM) via integrins. ECM stiffness is known to enhance integrin clustering and response to epidermal growth factor (EGF), but we lack information on when or if these mechanosensitive growth factor receptors and integrins converge intracellularly. Towards closing this knowledge gap, we combined a biomaterial platform with transcriptomics, molecular biology, and functional assays to link integrin-mediated mechanosensing and epidermal growth factor receptor (EGFR) signaling...
June 2, 2018: Biomaterials
https://www.readbyqxmd.com/read/29909028/tunable-spr-based-remote-actuation-of-bimetallic-core-shell-nanoparticles-coated-stimuli-responsive-polymer-for-switchable-chemo-photothermal-synergistic-cancer-therapy
#12
Mitra Amoli-Diva, Rasoul Sadighi-Bonabi, Kamyar Pourghazi
New dual light/temperature-responsive nanocarriers were synthesized using bimetallic plasmonic Au-Ag and Ag-Au nanoparticles (NPs) as cores of vehicles which subsequently functionalized with a UCST-based poly acrylamide-co-acrylonitrile using reversible addition-fragmentation chain transfer for spatiotemporally controlled chemo-photothermal synergistic cancer therapy. The bimetallic cores were assigned to sense wavelengths close to the localized SPR of monometallic NP shell to produce heat which not only can increase the surrounding temperature over the UCST of polymer to open the its valves and promote drug diffusion, but also can kill cancerous cells through photothermal effects with increasing in environment temperature nearly 18 °C after about 5 min radiation...
June 14, 2018: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29908898/oncologic-safety-of-skin-sparing-mastectomy-followed-by-immediate-reconstruction-in-young-patients-with-breast-cancer
#13
Sae Byul Lee, Jong Won Lee, Byung Ho Son, Jin Sup Eom, Eun Key Kim, Taik Jong Lee, Sei-Hyun Ahn
BACKGROUNDS: This study aimed to compare the oncologic outcomes of nipple-sparing mastectomy (NSM)/skin-sparing mastectomy (SSM) followed by immediate reconstruction with those of conventional mastectomy (CM) in young patients aged under 35 years old with breast cancer. METHODS: We analyzed retrospectively 2889 patients who underwent mastectomy for breast cancer at Asan Medical Center from January 2003 to December 2008. We compared NSM/SSM followed by immediate reconstruction with CM in patients under 35 years old by analyzing clinicopathologic features, breast cancer specific survival rate (BCSS), distant metastasis free survival rate (DMFS), and local recurrence rate (LRR)...
June 13, 2018: Asian Journal of Surgery
https://www.readbyqxmd.com/read/29908625/chest-surgery-for-transgender-and-gender-nonconforming-individuals
#14
REVIEW
Karel E Y Claes, Salvatore D'Arpa, Stan J Monstrey
Chest surgery can greatly facilitate the experience of living in a gender role. For transfeminine chest surgery, most surgeons recommend a 12-month period of feminizing hormone therapy prior to breast augmentation. For those who already have some breast volume due to hormone treatment, lipofilling can be a good option. Transmasculine chest surgery includes mastectomy and creation of a male chest. Preoperative parameters to be evaluated include breast volume, degree of excess skin, nipple-areola complex size and position, and skin elasticity...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908621/breast-and-body-contouring-for-transgender-and-gender-nonconforming-individuals
#15
REVIEW
Shane D Morrison, Stelios C Wilson, Scott W Mosser
Even after long-term hormone therapy, many transwomen still have challenges in the size and shape of their breasts and also of the contour of their trunk areas. Though distinct anthropomorphic differences in skeletal structure exist and pose limitations to an ideal result, considerable improvements can be obtained through breast augmentation and trunk feminization. There are challenges that are unique to the transfeminine chest and trunk, and important considerations for the priority of fat grafting to the buttocks and hips when grafted fat is in short supply...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908618/hormonal-management-for-transfeminine-individuals
#16
REVIEW
Jessica Abramowitz, Vin Tangpricha
Transfeminine individuals are treated with estradiol and anti-androgen agents to transition to a more feminine appearance. The physical changes that occur with estradiol therapy include breast development, body fat redistribution, and decreased muscle mass. Transfeminine treatment regimens require monitoring and dose adjustments to achieve appropriate physiologic targets to enhance feminization and decrease risk of adverse outcomes. Adverse effects associated with estradiol use include thromboembolic disease, macroprolactinoma, breast cancer, coronary artery disease, cerebrovascular disease, cholelithiasis, and hypertriglyceridemia...
July 2018: Clinics in Plastic Surgery
https://www.readbyqxmd.com/read/29908584/emotional-healing-with-unconventional-breast-tattoos-the-role-of-temporary-tattoos-in-the-recovery-process-after-breast-carcinoma-and-mastectomy
#17
Lindsay P Osborn, Philip R Cohen
The healing process after breast cancer treatment is predominantly focused toward the physical changes to the body that a patient has experienced. Breast reconstructions are considered standard of care after mastectomy, and the nipple and areolar complex is often reconstructed as well, using a combination of skin graft and tattoo. A patient who decided to forego nipple reconstruction and areolar tattooing and instead chooses to apply decorative temporary tattoos to her breast reconstruction is described. Compared with permanent tattoos, these unconventional tattoos allow the patient to change the design to fit her mood...
May 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29908524/neoadjuvant-radiotherapy-changing-the-treatment-sequence-to-allow-immediate-free-autologous-breast-reconstruction
#18
Kimberley Hughes, Derek Neoh
BACKGROUND:  Locally advanced breast cancer (LABC) is traditionally treated with a multimodal approach of chemotherapy, surgery, and postmastectomy radiotherapy (PMRT). The advantages of immediate breast reconstruction (IBR) are well described and include improved aesthetic outcomes, fewer surgical procedures, shorter treatment period, and a higher quality of life. However, this sequence makes immediate free autologous reconstruction more challenging as PMRT can have deleterious and unpredictable effects on the flap...
June 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29908443/novel-pyrimidinic-selenourea-induces-dna-damage-cell-cycle-arrest-and-apoptosis-in-human-breast-carcinoma
#19
Flavio A R Barbosa, Tâmila Siminski, Rômulo F S Canto, Gabriela M Almeida, Nádia S R S Mota, Fabiana Ourique, Rozangela Curi Pedrosa, Antonio Luiz Braga
Novel pyrimidinic selenoureas were synthesized and evaluated against tumour and normal cell lines. Among these, the compound named 3j initially showed relevant cytotoxicity and selectivity for tumour cells. Three analogues of 3j were designed and synthesized keeping in view the structural requirements of this compound. Almost all the tested compounds displayed considerable cytotoxicity. However, 8a, one of the 3j analogues, was shown to be highly selective and cytotoxic, especially for breast carcinoma cells (MCF-7) (IC50  = 3...
June 11, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908344/nitroxide-radical-containing-nanoparticles-attenuate-tumorigenic-potential-of-triple-negative-breast-cancer
#20
Babita Shashni, Yukio Nagasaki
The critical importance of reactive oxygen species (ROS) as oncogene activators and essential secondary messengers in cancer cell survival have been widely reported. Since oxidative stress has been implicated as being pivotal in various cancers, antioxidant therapy seems an apt strategy to abrogate ROS-mediated cellular processes to attenuate cancers. We therefore synthesized ROS scavenging nitroxide radical-containing nanoparticles (RNPs); pH insensitive RNPO and pH sensitive RNPN , to impede the proliferative and metastatic characteristics of the triple negative breast cancer cell line, MDA-MB-231, both in vitro and in vivo...
May 26, 2018: Biomaterials
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