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https://www.readbyqxmd.com/read/28928880/in-surgical-colon-cancer-patients-extended-duration-thromboprophylaxis-30-days-with-the-highest-dose-of-tinzaparin-4-500-iu-s-c-q-d-normalizes-the-postoperative-vegf-levels
#1
Michail Mitsis, Panagiotis Koliou, Christina Bali, Evangelia Ntounousi, Vasileios Tatsis, Vasileios Nousias, Georgios D Lianos, Georgios Vartholomatos, Dimitrios Nastos
Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis with a Low Molecular Weight Heparin (LMWH) in surgical cancer patients, further to thromboembolic protection, may exert some anti-neoplastic properties, as well. The aim of our study was to assess the potential impact of the LMWH Tinzaparin (Innohep® - Leo Pharma, Copenhagen, Denmark), given at different doses and for different perioperative (peri-op) periods, upon the post-op variability of serum VEGF levels in surgical CC patients...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28919950/chromosome-mapping-of-a-tc1-like-transposon-in-species-of-the-catfish-ancistrus
#2
Keteryne Rodrigues da Silva, Sandra Mariotto, Liano Centofante, Patricia Pasquali Parise-Maltempi
The Tc1 mariner element is widely distributed among organisms and have been already described in different species of fish. The genus Ancistrus (Kner, 1854) has 68 nominal species and is part of an interesting taxonomic and cytogenetic group, as well as presenting a variation of chromosome number, ranging from 2n=34 to 54 chromosomes, and the existence of simple and multiple sex chromosome system and the occurrence of chromosomal polymorphisms involving chromosomes that carry the nucleolus organizer region...
2017: Comparative Cytogenetics
https://www.readbyqxmd.com/read/28917596/response-rate-to-chemotherapy-after-immune-checkpoint-inhibition-in-metastatic-urothelial-cancer
#3
Bernadett Szabados, Nick van Dijk, Yen Zhi Tang, Michiel van der Heijden, Akhila Wimalasingham, Alfonso Gomez de Liano, Simon Chowdhury, Simon Hughes, Sarah Rudman, Mark Linch, Thomas Powles
Immune checkpoint inhibitors (ICIs) are active in metastatic urothelial carcinoma (MUC). They have joined chemotherapy (CT) as a standard of care. Here, we investigate the activity of CT after progression on ICIs. Two cohorts of sequential patients with MUC were described (n=28). Cohort A received first-line ICIs followed by CT after progression. Cohort B received CT after failure of first-line platinum-based CT followed by ICIs. Response rate (RR) to CT was assessed using Response Evaluation Criteria in Solid Tumors (RECIST v1...
September 13, 2017: European Urology
https://www.readbyqxmd.com/read/28820159/surgical-treatment-of-superior-oblique-palsy-predictors-of-outcome
#4
Pilar Merino Sanz, José Escribano, Pilar Gómez de Liaño, Rubén Yela
PURPOSE: The purpose of this study was to evaluate the incidence and outcome of surgically treated superior oblique palsy (SOP) and the factors involved in its resolution. METHODS: We performed a retrospective study of 76 patients who underwent surgery for SOP. We recorded data from the physical examination and the number and type of procedures performed. Favorable outcome was defined as resolution of or improvement in torticollis (≤5°) and diplopia in primary position (PP) and downgaze or as vertical deviation (VD) <5 prism diopters (pd) in PP and 10 pd in the oblique diagnostic position...
August 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/28743566/mortality-prediction-in-patients-with-acute-kidney-injury-requiring-renal-replacement-therapy-after-cardiac-surgery
#5
Inga Skarupskienė, Dalia Adukauskienė, Jurgita Kuzminskienė, Laima Rimkutė, Vilma Balčiuvienė, Edita Žiginskienė, Vytautas Kuzminskis, Agnė Adukauskaitė, Daiva Pentiokinienė, Inga Arūnė Bumblytė
BACKGROUND AND OBJECTIVE: Acute kidney injury (AKI) is a common and potentially serious postoperative complication after cardiac surgery, and it remains a cause of major morbidity and mortality. The aim of our study was to assess the prognostic illness severity score and to estimate the significant risk factors for poor outcome of patients with AKI requiring renal replacement therapy (RRT) after cardiac surgery. MATERIALS AND METHODS: We retrospectively analyzed data of adult (>18 years) patients (n=111) who underwent open heart surgery and had developed AKI with need for RRT...
July 14, 2017: Medicina
https://www.readbyqxmd.com/read/28743412/pseudoexfoliation-signs-in-the-anterior-segment-assessed-by-optical-coherence-tomography-and-scheimpflug-device
#6
J I Fernández-Vigo, L de-Pablo Gómez de Liaño, I Sánchez-Guillen, A Macarro-Merino, C Fernández-Vigo, J García-Feijóo, J A Fernández-Vigo
OBJECTIVE: To evaluate different anterior segment parameters in eyes with pseudoexfoliation (PSX), fellow eyes, and controls using optical coherence tomography and a Scheimpflug imaging system. METHODS: Three groups were studied: 44 eyes of 44 patients with PSX, 30 clinically unaffected fellow eyes, and 148 eyes of 148 healthy controls. The anterior chamber depth and volume, corneal volume and thickness, pupil diameter and corneal densitometry were measured using a Scheimpflug imaging system (Pentacam, Oculus Inc...
July 22, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28734565/topical-brinzolamide-in-congenital-nystagmus-a-retrospective-study
#7
M Nieves-Moreno, L Morales Fernández, B Domingo Gordo, E Maillo, E Diaz, R Gómez-de-Liaño
OBJECTIVE: To evaluate the effect of treatment with topical brinzolamide on visual acuity and nystagmus intensity in patients with congenital nystagmus. MATERIAL AND METHODS: A retrospective study was designed in which the clinical records of 14 patients with congenital nystagmus were reviewed. All patients underwent a complete ophthalmological examination and a Perea video-oculography (VOG) before, and three days after, initiation of treatment with topical brinzolamide (Azopt)...
July 19, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28720313/binocular-diplopia-in-a-tertiary-hospital-aetiology-diagnosis-and-treatment
#8
P Merino, D Fuentes, P Gómez de Liaño, M A Ordóñez
OBJECTIVE: To study the causes, diagnosis and treatment in a case series of binocular diplopia. MATERIAL AND METHOD: A retrospective chart review was performed on patients seen in the Diplopia Unit of a tertiary centre during a one-year period. Diplopia was classified as: acute≤1 month since onset; subacute (1-6 months); and chronic (>6 months). Resolution of diplopia was classified as: spontaneous if it disappeared without treatment, partial if the course was intermittent, and non-spontaneous if treatment was required...
July 15, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28719417/anterior-chamber-angle-and-trabecular-meshwork-measurements-made-by-fourier-domain-optical-coherence-tomography-in-healthy-white-children
#9
José I Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Cristina Fernández-Vigo, Gabriel Arcos-Villegas, Cristina Fernández-Pérez, Julián García-Feijóo, José Á Fernández-Vigo
PURPOSE: To obtain anterior chamber angle and trabecular meshwork (TM) measurements by Fourier-domain optical coherence tomography (FD-OCT) in a population of healthy white children. MATERIALS AND METHODS: This was a cross-sectional study examining 409 right eyes of 409 children. Trabecular-iris angle (TIA) and TM length and area were measured by FD-OCT (RTVue 100) in the nasal and temporal quadrants to analyze correlations between angle or TM measurements and age, sex, and refractive error...
July 17, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28706959/sensitivity-specificity-and-predictive-values-of-anterior-chamber-tap-in-cases-of-bacterial-endophthalmitis
#10
Carl Sjoholm-Gomez de Liano, Vidal F Soberon-Ventura, Guillermo Salcedo-Villanueva, Abril Santos-Palacios, Jose Luis Guerrero-Naranjo, Jans Fromow-Guerra, Gerardo García-Aguirre, Virgilio Morales-Canton, Raul Velez-Montoya
BACKGROUND: To assess the sensitivity, specificity, positive predictive value and negative predictive value of anterior chamber tap for the diagnosis of bacterial endophthalmitis on a population with high prevalence. METHODS: Retrospective, single centre, case series study. We reviewed all medical records with clinical diagnosis of bacterial endophthalmitis in our hospital from January 1st, 2000 to December 31st 2014. From each record, we documented general demographic data, best corrected visual acuity and vitreous and aqueous tap microbiological results...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/28662940/impacts-of-implantable-collamer-lens-v4c-placement-on-angle-measurements-made-by%C3%A2-optical-coherence-tomography-two-year-follow-up
#11
José Ignacio Fernández-Vigo, Ana Macarro-Merino, Cristina Fernández-Vigo, José Ángel Fernández-Vigo, Lucía De-Pablo-Gómez-de-Liaño, Cristina Fernández-Pérez, Julián García-Feijóo
PURPOSE: To determine iridocorneal angle changes produced after 2 years of implantable collamer lens (ICL) V4c (STAAR Surgical AG, Nidau, Switzerland) placement by Fourier-domain optical coherence tomography (FD-OCT). DESIGN: Prospective interventional case series. METHODS: In 54 eyes of 27 myopic subjects FD-OCT iridocorneal angle measurements were made before and 1 month, 3 months, 1 year, and 2 years after ICL implant. Trabecular-iris angle (TIA), angle opening distance 500 μm from the scleral spur (AOD500), and iridotrabecular contact length (TICL) were compared among these time points and the nasal, temporal, and inferior quadrants...
September 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28601401/orbital-magnetic-resonance-imaging-is-useful-in-age-related-distance-esotropia
#12
Pilar Gómez de Liaño Sanchez, Gloria Olavarri González, Pilar Merino Sanz, Jose C Escribano Villafruela
PURPOSE: To describe findings for orbital magnetic resonance imaging (MRI) in patients with age-related distance esotropia (ARDE). METHODS: We compared 31 orbital MRI from patients with ARDE (77±7 SD years) with 2 control groups: 32 orbits from individuals aged 18-50 years (33±8 SD years) and 16 orbits from individuals aged >60 years (77±7 SD years). MRI scans were acquired using 3D fast field echo in T1 sequence without fat saturation. Exclusion criteria for all groups were neurological or thyroid disease and a relevant ophthalmological history (e...
June 7, 2017: Journal of Optometry
https://www.readbyqxmd.com/read/28363147/renewable-energy-production-by-photoelectrochemical-oxidation-of-organic-wastes-using-wo3-photoanodes
#13
Dimitrios Raptis, Vassilios Dracopoulos, Panagiotis Lianos
The present work has studied renewable hydrogen production by photoelectrocatalytic degradation of model organic substances representing biomass derived organic wastes. Its purpose was to show that renewable energy can be produced by consuming wastes. The study has been carried out by employing nanoparticulate WO3 photoanodes in the presence of ethanol, glycerol or sorbitol, i.e. three substances which are among typical biomass products. In these substances, the molecular weight and the number of hydroxyl groups increases from ethanol to sorbitol...
March 22, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28326457/minimally-invasive-surgical-approaches-for-pancreatic-adenocarcinoma-recent-trends
#14
REVIEW
Georgios D Lianos, Dimitrios K Christodoulou, Konstantinos H Katsanos, Christos Katsios, Georgios K Glantzounis
BACKGROUND: Pancreatic resection for cancer represents a real challenge for every surgeon. Recent improvements in laparoscopic experience, minimally invasive surgical techniques and instruments make now the minimally invasive approach a real "triumph." There is no doubt that minimally invasive surgery has replaced with great success conventional surgery in many fields, including surgical oncology. METHODS AND RESULTS: However, its progress in pancreatic resection for adenocarcinoma has been dramatically slow...
June 2017: Journal of Gastrointestinal Cancer
https://www.readbyqxmd.com/read/28260181/breast-cancer-in-young-women-an-overview
#15
REVIEW
Zoi Anastasiadi, Georgios D Lianos, Eleftheria Ignatiadou, Haralampos V Harissis, Michail Mitsis
Despite dramatic advances in cancer research setting, breast cancer remains a major health problem and represents currently a top biomedical research priority. Worldwide, breast cancer is the most common cancer affecting women, and its incidence and mortality rates are expected to increase significantly the next years. Recently the researchers' interest has been attracted by breast cancer arising in young women. Current evidence suggests that in women aged <45 years, breast cancer is unquestionably the leading cause of cancer-related deaths...
March 4, 2017: Updates in Surgery
https://www.readbyqxmd.com/read/28256650/synthesis-of-new-photosensitive-h2bbq-2-zncl4-2-zncl-2-%C3%AE-bbh-complexes-through-selective-oxidation-of-h2o-to-h2o2
#16
M Stylianou, I Hadjiadamou, C Drouza, S C Hayes, E Lariou, I Tantis, P Lianos, A C Tsipis, A D Keramidas
A new two-electron photosensitizer, H2BBQ(2+)[ZnCl4](2-)/[(ZnCl)2(μ-BBH)] (BBQ stands for 2,5-bis[bis(pyridin-2-ylmethyl)amino]-1,4-quinone and BBH stands for 2,5-bis[bis(pyridin-2-ylmethyl)amino]-1,4-hydroquinone), has been synthesized and the oxidation state of the ligand was determined by X-ray crystallography and NMR spectroscopy. Under light illumination the H2BBQ(2+)[ZnCl4](2-) + ZnCl2 is reduced quantitatively to [(ZnCl)2(μ-BBH)] (pH ∼ 5) oxidizing H2O to H2O2 as is evident by trap experiments. Electrochemistry gave a reversible two-electron ligand-centered redox wave for [(ZnCl)2(μ-BBH)]...
March 14, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28248707/reply-to-adverse-effects-of-hyperchloraemic-solutions
#17
Ana B Serrano, Ángel M Candela-Toha, Fernando Liaño
No abstract text is available yet for this article.
April 2017: European Journal of Anaesthesiology
https://www.readbyqxmd.com/read/28196580/anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-with-renal-involvement-analysis-of-89-cases
#18
Fernando Caravaca-Fontán, Estefanía Yerovi, María Delgado-Yagu E, Cristina Galeano, Saúl Pampa-Saico, Maria Teresa Tenorio, Fernando Liaño
INTRODUCTION: The anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis with renal involvement are associated with high morbi-mortality. In this study we analyse if the prognosis of these diseases have improved in recent years, and which factors influence the outcomes. MATERIAL AND METHODS: Retrospective single-centre observational study, which included all patients diagnosed with microscopic polyangiitis and granulomatosis with polyangiitis with renal involvement in the last 25 years...
January 6, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/28192063/karyotype-diversity-in-doradidae-siluriformes-doradoidea-and-presence-of-the-heteromorphic-zz-zw-sex-chromosome-system-in-the-family
#19
Fábio Hiroshi Takagui, Lucas Ferreira de Moura, Daniela Cristina Ferreira, Liano Centofante, Carla de Andrade Vitorino, Vanessa Bueno, Vladimir Pavan Margarido, Paulo Cesar Venere
Karyotypes and other chromosomal markers as revealed by conventional and molecular cytogenetic protocols in four species of the catfish family Doradidae from the Araguaia-Tocantins river basin, namely Hassar wilderi, Leptodoras cataniae, Tenellus leporhinus and Tenellus trimaculatus were examined. All species had diploid chromosome number 2n = 58 and karyotypes dominated by biarmed chromosomes, simple NOR phenotype, that is, one chromosome pair bearing this site in terminal position, but some differences in karyotypes and distribution of constitutive heterochromatin, position of rDNA sites...
June 2017: Zebrafish
https://www.readbyqxmd.com/read/28125906/difluoromethylornithine-in-cancer-new-advances
#20
REVIEW
George A Alexiou, Georgios D Lianos, Vassileios Ragos, Vasiliki Galani, Athanassios P Kyritsis
Difluoromethylornithine (DFMO; eflornithine) is an irreversible suicide inhibitor of the enzyme ornithine decarboxylase which is involved in polyamine synthesis. Polyamines are important for cell survival, thus DFMO was studied as an anticancer agent and as a chemoprevention agent. DFMO exhibited mainly cytostatic activity and had single agent efficacy as well as activity in combination with other chemotherapeutic drugs for some cancers and leukemias. Herewith, we summarize the current knowledge of the anticancer and chemopreventive properties of DFMO and assess the status of clinical trials...
April 2017: Future Oncology
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