Read by QxMD icon Read


Maria G Detsika, Pu Duann, Vassilios Atsaves, Apostolos Papalois, Elias A Lianos
Complement-activation controllers, including decay accelerating factor (DAF), are gaining emphasis as they minimize injury in various dysregulated complement-activation disorders, including glomerulopathies. Heme oxygenase (HO)-1 overexpression or induction has been shown to attenuate injury in complement-dependent models of glomerulonephritis. This study investigated whether up-regulation of DAF by heme oxygenase 1 (HO-1) is an underlying mechanism by using Hmox-1-deficient rats (Hmox1(+/-); Hmox1(-/-)) or rats with Hmox-1 overexpression targeted to glomerular epithelial cells (GEC(Hmox-1)), which are particularly vulnerable to complement-mediated injury owing to their terminally differentiated nature...
September 20, 2016: American Journal of Pathology
José Ignacio Fernández-Vigo, Ana Macarro-Merino, Joaquín Fernández-Francos, Lucía De-Pablo-Gómez-de-Liaño, José María Martínez-de-la-Casa, Julián García-Feijóo, José Ángel Fernández-Vigo
PURPOSE: To compare the behavior of aqueous humor (AH) and analyze flow differences by comparing the volume and velocity of the flow after two different models of implantable collamer lens (ICL) placement. METHODS: Computational fluid dynamics with numerical simulation using Ansys Fluent software was performed to compare the AH flow through a peripheral iridotomy (PI), which is typically performed after implantation of a V4b lens to the central hole of a V4c lens...
September 1, 2016: Investigative Ophthalmology & Visual Science
M Carmen Lafita-Navarro, Rosa Blanco, Jorge Mata-Garrido, Judit Liaño-Pons, Olga Tapia, Lucía García-Gutiérrez, Eva García-Alegría, María T Berciano, Miguel Lafarga, Javier León
MXD1 is a protein that interacts with MAX, to form a repressive transcription factor. MXD1-MAX binds E-boxes. MXD1-MAX antagonizes the transcriptional activity of the MYC oncoprotein in most models. It has been reported that MYC overexpression leads to augmented RNA synthesis and ribosome biogenesis, which is a relevant activity in MYC-mediated tumorigenesis. Here we describe that MXD1, but not MYC or MNT, localizes to the nucleolus in a wide array of cell lines derived from different tissues (carcinoma, leukemia) as well as in embryonic stem cells...
August 31, 2016: Oncotarget
P Merino, P Gómez de Liaño, Y Ah Kim
CLINICAL CASE: A patient diagnosed with Duane syndrome underwent an augmented superior rectus transposition (SRT) to lateral rectus (LR) and medial rectus (MR) recession. Vertical, torsional deviation and diplopia were observed post-operatively. Removal of the Foster suture and superior rectus recession resolved the symptoms. DISCUSSION: SRT to LR is proposed in Duane syndrome with a favorable outcome. The benefit of SRT is open to debate. It could be an alternative for the vertical rectus transposition when MR recession has to be operated on in the same procedure, or in the immediate post-operative period, in order to decrease the risk of anterior segment ischaemia...
August 16, 2016: Archivos de la Sociedad Española de Oftalmología
Vassilios Atsaves, Panagiota Makri, Maria G Detsika, Alexandra Tsirogianni, Elias A Lianos
BACKGROUND/AIMS: Induction of heme oxygenase 1 (HO-1) in glomerular epithelial cells (GEC) in response to injury is poor and this may be a disadvantage. We, therefore, explored whether HO-1 overexpression in GEC can reduce proteinuria induced by puromycin aminonucleoside (PAN) or in anti-glomerular basement membrane (GBM) antibody (Ab)-mediated glomerulonephritis (GN). METHODS: HO-1 overexpression in GEC (GECHO-1) of Sprague-Dawley rats was achieved by targeting a FLAG-human (h) HO-1 using transposon-mediated transgenesis...
2016: Nephron
Elias N Katsoulieris, Garyfalia I Drossopoulou, Eleni S Kotsopoulou, Dimitrios V Vlahakos, Elias A Lianos, Effie C Tsilibary
OBJECTIVE: Chronic hyperglycaemia, as seen in type II diabetes, results in both morphological and functional impairments of podocytes in the kidney. We investigated the effects of high glucose (HG) on the insulin signaling pathway, focusing on cell survival and apoptotic markers, in immortalized human glomerular cells (HGEC; podocytes) and isolated glomeruli from healthy rats. METHODS AND FINDINGS: HGEC and isolated glomeruli were cultured for various time intervals under HG concentrations in the presence or absence of insulin...
2016: PloS One
L de-Pablo-Gómez-de-Liaño, J I Fernández-Vigo, N Ventura-Abreu, L Morales-Fernández, J García-Feijóo, R Gómez-de-Liaño
OBJECTIVE: To assess the agreement between intraoperative measurements of the limbus-insertion distance of the extraocular muscles with those measured by spectral domain optical coherence tomography. METHODS: An analysis was made of a total of 67 muscles of 21 patients with strabismus. The limbus-insertion distance of the horizontal rectus muscles were measured using pre-operative SD-OCT and intra-operatively in 2 ways: 1) direct, after a conjunctival dissection in patients who underwent surgery, or 2) transconjunctival in patients who were treated with botulinum toxin, or in those who were not going to be operated...
June 20, 2016: Archivos de la Sociedad Española de Oftalmología
Diovani Piscor, Liano Centofante, Patricia Pasquali Parise-Maltempi
Repetitive sequences and their chromosomal locations have been widely studied in species of the Astyanax genus. However, the chromosomal organization of U2 snDNA remains largely unknown. The aims of this study were to examine the chromosomal contexts of U2 snRNA and 5S rRNA genes in Astyanax species and determine the degree of chromosome morphological similarity between species with different diploid numbers. Clusters of U2 snDNA and 5S rDNA were determined in nine species of Astyanax, including two karyomorphs of Astyanax fasciatus Cuvier, 1819...
June 22, 2016: Zebrafish
G K Glantzounis, E Tokidis, S-P Basourakos, E E Ntzani, G D Lianos, G Pentheroudakis
BACKGROUND: Primary liver and biliary cancers are very aggressive tumors. Surgical treatment is the main option for cure or long term survival. The main purpose of this systematic review is to underline the indications for portal vein embolization (PVE), in patients with inadequate future liver remnant (FLR) and to analyze other parameters such as resection rate, morbidity, mortality, survival after PVE and hepatectomy for primary hepatobiliary tumors. Also the role of trans-arterial chemoembolization (TACE) before PVE, is investigated...
June 1, 2016: European Journal of Surgical Oncology
P Gómez de Liaño Sánchez, G Olavarri González, P Merino Sanz, J C Escribano Villafruela
OBJECTIVE: To describe the clinical characteristics and surgical outcomes of a group of patients with age-related distance esotropia (ARDE). METHODS: A retrospective study was conducted on a consecutive case series of 16 adult patients diagnosed with ARDE between 2008 and 2015. The clinical features evaluated included mean age and gender, primary position deviations at distance and near, measured in prism dioptres (pd), treatment offered in each case, and post-surgical deviations...
May 31, 2016: Archivos de la Sociedad Española de Oftalmología
Maria G Detsika, Vasiliki Lygirou, Vassileios Frantzis, Jerome Zoidakis, Vassilios Atsaves, Elpida Poulaki, Hariklia Gakiopoulou, Antonia Vlahou, Elias A Lianos
BACKGROUND: The cytoprotective effect of heme oxygenase (HO)-1 in various forms of renal glomerular injury is established. However, little is known on the role of HO-1 in preserving glomerular structural/functional integrity in the absence of injury. The present study addressed this question in HO-1-deficient rats. METHODS: HO-1-deficient rats were generated using zinc finger nuclease-mediated HO-1 gene (Hmox1) disruption and studied. Glomeruli were isolated from HO-1-deficient (Hmox1-/-) rats and their wild type (WT) littermates for proteomic analysis...
2016: American Journal of Nephrology
Lucía De-Pablo-Gómez-de-Liaño, José Ignacio Fernández-Vigo, Néstor Ventura-Abreu, Laura Morales-Fernández, Cristina Fernández-Pérez, Julián García-Feijóo, Rosario Gómez-de-Liaño
PURPOSE: To determine the distance of the horizontal rectus muscle insertion to the limbus using spectral domain optical coherence tomography (SD-OCT) and to evaluate whether results are correlated with sex, age, or axial length. METHODS: The right eyes of healthy, white subjects were imaged with SD-OCT. Subjects' sex and age were recorded, and axial length was measured using an optical biometer. The distance from the horizontal rectus insertion to the limbus was measured...
June 2016: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Pu Duann, Elias A Lianos, Jianjie Ma, Pei-Hui Lin
Kidney is a vital organ with high energy demands to actively maintain plasma hemodynamics, electrolytes and water homeostasis. Among the nephron segments, the renal tubular epithelium is endowed with high mitochondria density for their function in active transport. Acute kidney injury (AKI) is an important clinical syndrome and a global public health issue with high mortality rate and socioeconomic burden due to lack of effective therapy. AKI results in acute cell death and necrosis of renal tubule epithelial cells accompanied with leakage of tubular fluid and inflammation...
2016: International Journal of Molecular Sciences
Georgios D Lianos, Georgios K Glantzounis
No abstract text is available yet for this article.
August 2016: Future Oncology
José L Casado, Jose M Del Rey, Sara Bañón, Carmen Santiuste, Mar Rodriguez, Ana Moreno, María J Perez-Elías, Fernando Liaño, Santiago Moreno
INTRODUCTION: Longitudinal data on the changes in kidney function and tubular abnormalities in case of tenofovir disoproxil fumarate (TDF) withdrawal or continuation are scarce. METHODS: Prospective study of 228 patients receiving TDF, with 3 sequential determinations of serum creatinine, estimated glomerular filtration rate (eGFR), phosphatemia, and different urinary parameters (protein, albumin, phosphaturia, uricosuria, and glycosuria). Changes were analyzed in patients who interrupted TDF as compared to those who continued the same regimen...
August 1, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Alberto Mangano, Georgios D Lianos, Dimitrios H Roukos, Sam E Mason, Hoon Yub Kim, Gianlorenzo Dionigi
Neuroendocrine tumors (NETs) are rare and heterogeneous tumors and there is a paucity of randomized clinical trials evaluating the different therapeutic strategies. Over recent years, some important molecular aspects have been investigated and multiple targeted therapies are currently available. One of the most promising targets for the therapy of NETs are the mTOR and angiogenic growth factor receptors. The advent of the inhibitors of the mTOR pathway, tyrosine kinase inhibitors and of somatostatin analogs have shown their efficacy in randomized clinical trials in terms of implementing clinical hormone-induced syndromes and progression-free survival of advanced NETs...
2016: Future Oncology
Luis F López-Cortés, Manuel A Castaño, Miguel A López-Ruz, María J Rios-Villegas, José Hernández-Quero, Dolores Merino, Patricia Jiménez-Aguilar, Manuel Marquez-Solero, Alberto Terrón-Pernía, Francisco Tellez-Pérez, Pompeyo Viciana, Francisco Orihuela-Cañadas, Zaira Palacios-Baena, David Vinuesa-Garcia, Jose M Fajardo-Pico, Alberto Romero-Palacios, Guillermo Ojeda-Burgos, Juan Pasquau-Liaño
BACKGROUND AND OBJECTIVE: Significant controversy still exists about ritonavir-boosted protease inhibitor monotherapy (mtPI/rtv) as a simplification strategy that is used up to now to treat patients that have not experienced previous virological failure (VF) while on protease inhibitor (PI) -based regimens. We have evaluated the effectiveness of two mtPI/rtv regimens in an actual clinical practice setting, including patients that had experienced previous VF with PI-based regimens. METHODS: This retrospective study analyzed 1060 HIV-infected patients with undetectable viremia that were switched to lopinavir/ritonavir or darunavir/ritonavir monotherapy...
2016: PloS One
Beatriz Gil-Gómez de Liaño, Franca Stablum, Carlo Umiltà
The effects of concurrent working memory load in attentional processes have been 1 of the most puzzling issues in cognitive psychology. Studies have shown detrimental effects, no effects, and even beneficial effects of working memory load in different attentional tasks. In the present study we attempted to replicate Kim, Kim, and Chun's (2005, Experiment 3b) findings of beneficial effects of concurrent working memory load in a spatial Stroop-like task. In 3 experiments in which our sample was 3 times larger than that in the original Kim et al...
January 2016: Journal of Experimental Psychology. General
Maria G Detsika, Vassileios Atsaves, Apostolos Papalois, Elias A Lianos
This article reports data describing HO-1 expression patterns of heme oxygenase (HO)-1 in isolated rat glomeruli and in cultured glomerular epithelial cells (GEC) in response to its natural substrate heme. Qualitative and quantitative data are presented to support presence of a HO-1 expression threshold in glomeruli but not in GEC. Interpretation of our data and further insight into HO-1 expression pattern in glomeruli may be found in 'HO-1 expression control in the rat glomerulus' [1].
December 2015: Data in Brief
Fernando Caravaca-Fontán, Saúl Pampa Saico, Sandra Elías Triviño, Cristina Galeano Álvarez, Antonio Gomis Couto, Inés Pecharromán de las Heras, Fernando Liaño
INTRODUCTION: Acute renal infarction (ARI) is an uncommon disease, whose real incidence is probably higher than expected. It is associated with poor prognosis in a high percentage of cases. OBJECTIVES: To describe the main clinical, biochemical and radiologic features and to determine which factors are associated with poor prognosis (death or permanent renal injury). MATERIALS AND METHODS: The following is a retrospective, observational, single-hospital-based study...
2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"