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Salivary biomarkers

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https://www.readbyqxmd.com/read/28210437/oral-manifestation-and-salivary-changes-in-renal-patients-undergoing-hemodialysis
#1
Marieh Honarmand, Leila Farhad-Mollashahi, Alireza Nakhaee, Fahimeh Sargolzaie
BACKGROUND: Salivary changes in hemodialysis patients may result in various oral manifestations. This research intended to determine oral manifestations and some salivary markers in hemodialysis patients. MATERIAL AND METHODS: This cross-sectional study was conducted on 30 hemodialysis patients (the patient group) and 30 healthy individuals (the control group). Saliva urea and calcium levels and pH values of the participants were measured, and oral manifestations such as pale mucosa, xerostomia, halitosis, changes in the sense of taste, increased calculus formation, gingival bleeding, etc...
February 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28202252/what-worries-parents-of-a-child-with-autism-evidence-from-a-biomarker-for-chronic-stress
#2
Vicki Bitsika, Christopher F Sharpley, Nicholas M Andronicos, Linda L Agnew
BACKGROUND: Previous studies have reported correlations between various aspects of the behaviour and symptomatology of children with Autism Spectrum Disorder (ASD) and their parents' self-reports of stress via standardised scales. AIMS: To extend that literature, a physiological index of parental chronic stress was used instead of their self-reports-dysregulation of the Diurnal Rhythm (DR) of the Hypothalamic-Pituitary-Adrenal (HPA) axis. METHODS: A sample of 149 parents of a child with ASD provided salivary cortisol at the predicted time of daily maximum cortisol concentration and at a time of daily lower concentration...
February 12, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/28198151/comparative-proteomic-analysis-of-the-influence-of-gender-and-acid-stimulation-on-normal-human-saliva-using-lc-ms-ms
#3
Xiaoping Xiao, Yaoran Liu, Zhengguang Guo, Xiaoyan Liu, Haidan Sun, Qian Li, Wei Sun
Human saliva is an important source for disease biomarker discovery. In this work, we investigate the influence of gender and acid stimulation on the normal human salivary proteome. Un-stimulated and acid-stimulated saliva samples from 5 males and 5 females were labeled with 4-plex iTRAQ and analyzed by 2-DLC MS/MS. A total of 1,770 proteins were identified, and 82 proteins in un-stimulated saliva were found to be gender-specific. These proteins were mainly associated with immune function, metabolism and inflammation...
February 15, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28195518/low-salivary-resolvin-d1-to-leukotriene-b4-ratio-predicts-carotid-intima-media-thickness-a-novel-biomarker-of-non-resolving-vascular-inflammation
#4
Silke Thul, Carlos Labat, Mohamed Temmar, Athanase Benetos, Magnus Bäck
Background Different lipid mediators may have opposing effects on vascular inflammation. For example, whereas leukotriene B4 (LTB4) transduces inflammation, resolvin D1 (RvD1), which is synthesized from the omega-3 fatty acid docosahexaenoic acid, facilitates the resolution of inflammation. The aim of this study was to determine the association of the RvD1/LTB4 ratio with subclinical atherosclerosis. Methods Saliva samples and ultrasound measurements of the intima media thickness of the carotid artery was obtained for 254 participants...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28186864/within-day-baseline-variation-in-salivary-biomarkers-in-healthy-men
#5
Firman Prathama Idris, Yunxia Wan, Xi Zhang, Chamindie Punyadeera
Saliva is an easily accessible sample and offers practical and noninvasive biomarker solutions as an alternative to blood and urine-based diagnostics. Saliva contains a plethora of biomolecules such as nucleic acids, hormones, proteins, and electrolytes. On the other hand, little is known on the extent to which the biomolecules in saliva vary over time within a given person. This baseline information is crucial for future development of robust saliva-based diagnostics. We have collected unstimulated whole mouth saliva from 20 healthy young men at four times during the day, including before and after a meal...
February 2017: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/28181836/volume-exercise-in-older-athletes-influences-inflammatory-and-redox-responses-to-acute-exercise
#6
Andre L Estrela, Aline Zaparte, Jefferson D da Silva, José C Moreira, James E Turner, Moisés E Bauer
To examine whether the volume of previous exercise training in older athletes influences inflammatory, redox and hormonal profiles, forty trained marathon runners were divided into higher-volume (HVG, ~480 min/week) and lower-volume groups (LVG, ~240 min/week). Plasma inflammatory proteins, redox biomarkers and salivary testosterone and cortisol, were assessed at rest and following two maximal acute exercise bouts. At rest, the LVG exhibited higher CRP, higher protein carbonyls and lower SOD activity compared to the HVG (p's<0...
February 9, 2017: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/28181173/hypothalamic-pituitary-adrenal-reactivity-to-acute-stress-an-investigation-into-the-roles-of-perceived-stress-and-family-resources
#7
Ezemenari M Obasi, Elizabeth A Shirtcliff, Lucia Cavanagh, Kristen L Ratliff, Delishia M Pittman, Jessica J Brooks
Rurally situated African Americans suffer from chronic exposure to stress that may have a deleterious effect on health outcomes. Unfortunately, research on potential mechanisms that underlie health disparities affecting the African American community has received limited focus in the scientific literature. This study investigated the relationship between perceived stress, family resources, and cortisol reactivity to acute stress. A rural sample of African American emerging adults (N = 60) completed a battery of assessments, the Trier Social Stress Test (TSST), and provided four samples of salivary cortisol: prior to receiving TSST instructions, prior to conducting the speech task, immediately following the TSST, and 15-20 min following the TSST...
February 8, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28178402/salivary-levels-of-interleukin-8-and-growth-factors-are-modulated-in-patients-with-geographic-tongue
#8
Amal Dafar, Maria Bankvall, Vegard Garsjö, Mats Jontell, Hülya Çevik-Aras
OBJECTIVES: The aim of the study was to determine the levels of salivary epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) as well as interleukin-8 (IL-8) in patients with geographic tongue (GT), as compared to control subjects. METHODOLOGY: An enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of IL-8, EGF, and VEGF in whole saliva samples collected from 34 patients with GT and 38 control subjects. The patients and controls were grouped and matched according to age, gender, and the presence of systemic diseases, which are factors that may influence the levels of salivary biomarkers...
February 8, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28177920/predictable-biomarkers-of-developing-lymphoma-in-patients-with-sj%C3%A3-gren-syndrome-a-nationwide-population-based-cohort-study
#9
Yu-Hsiang Chiu, Chi-Hsiang Chung, Kuen-Tze Lin, Chin-Sheng Lin, Jia-Hong Chen, Hsiang-Cheng Chen, Ren-Yeong Huang, Chi-Tsung Wu, Feng-Cheng Liu, Wu-Chien Chien
Sjögren syndrome (SS) is commonly known to be correlated with lymphoma. This study included 16,396 individuals in the SS cohort and 65,584 individuals in the non-SS cohort, all of whom were enrolled in the Taiwan National Health Insurance database between 2000 and 2010. We evaluated the risk factors of non-Hodgkin's lymphoma (NHL) in the primary SS cohort by applying a Cox multivariable proportional-hazards model. We increased the correlation of patients with SS and NHL, with an adjusted HR of 4.314 (95% CI 2...
February 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177057/salivary-cortisol-and-%C3%AE-amylase-subclinical-indicators-of-stress-as-cardiometabolic-risk
#10
S Cozma, L C Dima-Cozma, C M Ghiciuc, V Pasquali, A Saponaro, F R Patacchioli
Currently, the potential for cardiovascular (CV) stress-induced risk is primarily based on the theoretical (obvious) side effects of stress on the CV system. Salivary cortisol and α-amylase, produced respectively by the hypothalamus-pituitary-adrenal (HPA) axis and the sympathetic-adrenomedullary (SAM) system during stress response, are still not included in the routine evaluation of CV risk and require additional and definitive validation. Therefore, this article overviews studies published between 2010 and 2015, in which salivary cortisol and α-amylase were measured as stress biomarkers to examine their associations with CV/CMR (cardiometabolic risk) clinical and subclinical indicators...
February 6, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28169251/levels-of-salivary-thiocyanate-and-its-relation-with-occurrence-of-micronuclei-using-exfoliative-cytology-in-smokers-and-nonsmokers
#11
Prachi Shrigopal Baldawa, Venkatesh V Kulkarni, Ajit V Koshy, Sabeer S Shaikh, Rucha Varu, Garima Srivastava
AIMS: To evaluate the levels of salivary thiocyanate and its relation with the occurrence of micronuclei (MN) using exfoliative cytology in smokers and nonsmokers. MATERIALS AND METHODS: One hundred and twenty patients were divided into 3 groups: nonsmoker group 1 (control), smokers group 2, and smokers group 3. Their saliva was collected and analyzed for thiocyanate levels, and exfoliative cytology was evaluated for the presence of MN. STATISTICAL ANALYSIS USED: Fisher's exact test and ANOVA test were used...
November 2016: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28166548/nicotine-carcinogen-and-toxin-exposure-in-long-term-e-cigarette-and-nicotine-replacement-therapy-users-a-cross-sectional-study
#12
Lion Shahab, Maciej L Goniewicz, Benjamin C Blount, Jamie Brown, Ann McNeill, K Udeni Alwis, June Feng, Lanqing Wang, Robert West
Background: Given the rapid increase in the popularity of e-cigarettes and the paucity of associated longitudinal health-related data, the need to assess the potential risks of long-term use is essential. Objective: To compare exposure to nicotine, tobacco-related carcinogens, and toxins among smokers of combustible cigarettes only, former smokers with long-term e-cigarette use only, former smokers with long-term nicotine replacement therapy (NRT) use only, long-term dual users of both combustible cigarettes and e-cigarettes, and long-term users of both combustible cigarettes and NRT...
February 7, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28152077/cytokeratin-14-contributes-to-collective-invasion-of-salivary-adenoid-cystic-carcinoma
#13
Xiao-Lei Gao, Jia-Shun Wu, Min-Xin Cao, Shi-Yu Gao, Xiao Cen, Ya-Ping Jiang, Sha-Sha Wang, Ya-Jie Tang, Qian-Ming Chen, Xin-Hua Liang, Yaling Tang
Collective invasion of cells plays a fundamental role in tissue growth, wound healing, immune response and cancer metastasis. This paper aimed to investigate cytokeratin-14 (CK14) expression and analyze its association with collective invasion in the invasive front of salivary adenoid cystic carcinoma (SACC) to uncover the role of collective invasion in SACC. Here, in the clinical data of 121 patients with SACC, the positive expression of CK14 was observed in 35/121(28.93%) of the invasive front of SACC. CK14 expression in the invasive front, local regional recurrence and distant metastasis were independent and significant prognostic factors in SACC patients...
2017: PloS One
https://www.readbyqxmd.com/read/28131073/maternal-salivary-cortisone-to-cortisol-ratio-in-late-pregnancy-an-improved-method-for-predicting-offspring-birth-weight
#14
Meredith Wilson, Zaneta Thayer
Overexposure to maternal cortisol in utero has been associated with lower birth weight of offspring. In order to regulate fetal exposure to this hormone, placental expression of 11-β-hydroxysteroid dehydrogenase-2, an enzyme that converts active cortisol to inactive cortisone, increases across pregnancy. Because of this increase in 11-βHSD2 activity, measuring maternal cortisol in isolation may not reflect actual fetal exposure to the hormone. Previous work by Hellgren et al. (2016) has shown that maternal serum cortisone:cortisol ratio was a better predictor of offspring birth weight than cortisol measured in isolation...
January 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28130626/simulated-airplane-headache-a-proxy-towards-identification-of-underlying-mechanisms
#15
Sebastian Bao Dinh Bui, Torben Petersen, Jeppe Nørgaard Poulsen, Parisa Gazerani
BACKGROUND: Airplane Headache (AH) occurs during flights and often appears as an intense, short lasting headache during take-off or landing. Reports are limited on pathological mechanisms underlying the occurrence of this headache. Proper diagnosis and treatments would benefit from identification of potential pathways involved in AH pathogenesis. This study aimed at providing a simulated airplane headache condition as a proxy towards identification of its underlying mechanisms. METHODS: Fourteen participants including 7 volunteers suffering from AH and 7 healthy matched controls were recruited after meeting the diagnostic and safety criteria based on an approved study protocol...
December 2017: Journal of Headache and Pain
https://www.readbyqxmd.com/read/28122643/identification-of-potential-saliva-and-tear-biomarkers-in-primary-sj%C3%A3-gren-s-syndrome-utilising-the-extraction-of-extracellular-vesicles-and-proteomics-analysis
#16
Lara A Aqrawi, Hilde Kanli Galtung, Beate Vestad, Reidun Øvstebø, Bernd Thiede, Shermin Rusthen, Alix Young, Eduarda M Guerreiro, Tor Paaske Utheim, Xiangjun Chen, Øygunn Aass Utheim, Øyvind Palm, Janicke Liaaen Jensen
BACKGROUND: There is a long-lasting need for non-invasive, more accurate diagnostic techniques when evaluating primary Sjögren's syndrome (pSS) patients. Incorporation of additional diagnostics involving screening for disease-specific biomarkers in biological fluid is a promising concept that requires further investigation. In the current study we aimed to explore novel disease biomarkers in saliva and tears from pSS patients. METHODS: Liquid chromatography-mass spectrometry (LC-MS) was performed on stimulated whole saliva and tears from 27 pSS patients and 32 healthy controls, and salivary and tear proteomic biomarker profiles were generated...
January 25, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28119068/differential-effects-of-eating-and-drinking-on-wellbeing-an-ecological-ambulatory-assessment-study
#17
Jana Strahler, Urs M Nater
INTRODUCTION: Various behaviors, such as physical activity and sleep, have been shown to have stress-reducing and beneficial effects on wellbeing. In contrast, the rewarding effects of eating and drinking have rarely been investigated, particularly using ecologically valid approaches, and little is known about mediating mechanisms on the biological level. METHODS: Seventy-seven healthy young adults completed items on eating and drinking as well as momentary wellbeing (measured by mood, energy, tension, stress and fatigue levels) on an iPod touch 5×/day for 4 consecutive days...
January 22, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28117682/salivary-diagnostics-point-of-care-diagnostics-of-mmp-8-in-dentistry-and-medicine
#18
REVIEW
Nilminie Rathnayake, Dirk-Rolf Gieselmann, Anna Maria Heikkinen, Taina Tervahartiala, Timo Sorsa
Human saliva is an easily accessible biological fluid and contains a variety of disease-related biomarkers, which makes it a potential diagnostic medium. The clinical use of salivary/oral fluid biomarkers to identify oral and systemic conditions requires the development of non-invasive screening and diagnostic technologies, and is among the main goals of oral fluid researchers. The analysis of the disease-specific oral and systemic biomarkers in saliva and oral fluids (i.e., mouth-rinse, gingival crevicular fluid (GCF) and peri-implantitis sulcular fluid (PISF)) is demanding...
January 20, 2017: Diagnostics
https://www.readbyqxmd.com/read/28113000/impact-of-obesity-on-orthodontic-tooth-movement-in-adolescents
#19
H F Saloom, S N Papageorgiou, G H Carpenter, M T Cobourne
Obesity is a widespread chronic inflammatory disorder characterized by an increased overall disease burden and significant association with periodontitis. The aim of this prospective clinical cohort study was to investigate the effect of obesity on orthodontic tooth movement. Fifty-five adolescent patients (27 males, 28 females) with a mean (SD) age of 15.1 (1.7) years and mean (SD) body mass index (BMI) of 30.2 (3.5) kg/m(2) in obese and 19.4 (2.2) kg/m(2) in normal-weight groups were followed from start of treatment to completion of tooth alignment with fixed orthodontic appliances...
January 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/28110240/lead-exposure-is-related-to-hypercortisolemic-profiles-and-allostatic-load-in-brazilian-older-adults
#20
Juliana N Souza-Talarico, Deborah Suchecki, Robert-Paul Juster, Pierrich Plusquellec, Fernando Barbosa Junior, Vinícius Bunscheit, Tania Marcourakis, Tatiane Martins de Matos, Sonia J Lupien
Lead levels (Pb) have been linked to both hyper- and hypo-reactivity of hypothalamic-pituitary-adrenal axis (HPA) axis to acute stress in animals and humans. Similarly, allostatic load (AL), the 'wear and tear' of chronic stress, is associated with inadequate HPA axis activity. We examined whether Pb levels would be associated with altered diurnal cortisol profile, as a primary mediator of AL, during aging. Pb levels were measured from blood samples (BPb) of 126 Brazilian individuals (105 women), between 50 and 82 years old...
January 19, 2017: Environmental Research
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