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Salivary biomarkers

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https://www.readbyqxmd.com/read/28415698/salivary-glycopatterns-as-potential-biomarkers-for-diagnosis-of-gastric-cancer
#1
Jian Shu, Hanjie Yu, Xiaojie Li, Dandan Zhang, Xiawei Liu, Haoqi Du, Jiaxu Zhang, Zhao Yang, Hailong Xie, Zheng Li
Gastric cancer (GC) is still an extremely severe health issue with high mortality due to the lacking of effective biomarkers. In this study, we aimed to investigate the alterations of salivary protein glycosylation related to GC and assess the possibility of salivary glycopatterns as potential biomarkers for the diagnosis of GC. Firstly, 94 patients with GC (n = 64) and atrophic gastritis (AG) (n = 30), as well as 30 age- and sex-matched healthy volunteers (HV) were enrolled in the test group to probe the difference of salivary glycopatterns using lectin microarrays, the results were validated by saliva microarrays and lectin blotting analysis...
March 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28404907/investigation-of-three-potential-autoantibodies-in-sjogren-s-syndrome-and-associated-malt-lymphoma
#2
Li Cui, Naseim Elzakra, Shuaimei Xu, Gary Guishan Xiao, Yan Yang, Shen Hu
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease which might progress to mucosal-associated lymphoid tissue lymphoma (pSS/MALT). Diagnosis of pSS requires an invasive tissue biopsy and a delay in diagnosis of pSS has been frequently reported. In this study, four proteins including cofilin-1, alpha-enolase, annexin A2 and Rho GDP-dissociation inhibitor 2 (RGI2) were found to be over-expressed in pSS and pSS/MALT by 2D gel electrophoresis/mass spectrometry, and the finding was verified by the microarray analysis and western blotting results...
February 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28403685/salivary-cortisol-responses-and-session-ratings-of-perceived-exertion-to-a-rugby-match-and-fatigue-test
#3
P C Caetano Júnior, M L Castilho, L Raniero
This study compared the effect of an official rugby match and a fatigue test on the salivary cortisol response of 13 rugby players. We also examined the relationship between this cortisol response and session ratings of perceived exertion (session-RPE). We collected saliva before and after the match and fatigue test and assessed physical effort intensity via session-RPE using a CR-10 scale. We measured cortisol concentration by enzyme-linked immunosorbent assays. Results were greater session-RPE and cortisol concentrations for the rugby match, compared with the fatigue test...
January 1, 2017: Perceptual and Motor Skills
https://www.readbyqxmd.com/read/28400582/detection-of-ama-m2-in-human-saliva-potentials-in-diagnosis-and-monitoring-of-primary-biliary-cholangitis
#4
Chong Lu, Xianliang Hou, Minwei Li, Lin Wang, Ping Zeng, Hongyu Jia, Jianing Chen, Yingfeng Wei, Hong He, Xiangdong Liu, Hongyan Diao
Serum anti-mitochondrial antibody type 2 (AMA-M2) is considered as a pivotal biomarker for the diagnosis of primary biliary cholangitis (PBC). However, serological tests have many limitations, including inconvenience, invasiveness, and infection risks. Thus, a less invasive approach to detect AMA-M2 titer is desirable. We examined salivary AMA-M2 of potential PBC patients and found that AMA-M2 could be detected only in saliva of serum AMA-M2-positive PBC patients, but not in saliva of serum AMA-M2-negative PBC patients, oral lichen planus patients (OLP) patients, or healthy controls...
April 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28397778/salivary-il-8-il-6-and-tnf-%C3%AE-as-potential-diagnostic-biomarkers-for-oral-cancer
#5
REVIEW
Haafsa Arshad Sahibzada, Zohaib Khurshid, Rabia Sannam Khan, Mustafa Naseem, Khalid Mahmood Siddique, Maria Mali, Muhammad Sohail Zafar
Saliva has been useful as a liquid biopsy for the diagnosis of various oral or systemic diseases, and oral squamous cell carcinoma (OSCC) is no exception. While its early detection and prevention is important, salivary cytokines expression, specifically of Interleukin-8 (IL-8), Interleukin-6 (IL-6) and Tumor necrosis factor (TNF-α), does contribute to the pathogenesis of cancer and these cytokines serve as potential biomarkers. Their excessive production plays a role in cancer progression and establishment of angiogenesis...
April 9, 2017: Diagnostics
https://www.readbyqxmd.com/read/28393236/metabolomic-analysis-of-the-saliva-of-japanese-patients-with-oral-squamous-cell-carcinoma
#6
Mitsuyoshi Ohshima, Keisuke Sugahara, Kiyohiro Kasahara, Akira Katakura
The aim of the present study was to characterize the metabolic systems in Japanese patients with oral squamous cell carcinoma (OSCC) using capillary electrophoresis-mass spectrometry (CE-MS) metabolome analysis of saliva samples. A previous study showed variations among ethnicities and tumor sites in the saliva metabolome of patients with OSCC using CE-MS. In the present study, saliva was obtained from 22 Japanese patients with OSCC and from 21 healthy controls who visited the Department of Dentistry, Oral and Maxillofacial Surgery, Tokyo Dental Collage Ichikawa General Hospital, Tokyo, Japan, and all samples were subject to comprehensive quantitative metabolome analysis using CE-MS...
April 6, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28389847/a-pilot-study-of-salivary-n-glycome-in-hbv-induced-chronic-hepatitis-cirrhosis-and-hepatocellular-carcinoma
#7
Yannan Qin, Yaogang Zhong, Tianran Ma, Jiaxu Zhang, Ganglong Yang, Feng Guan, Zheng Li, Baozhen Li
Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV), which can lead to chronic liver disease and put people at high risk of death from cirrhosis of the liver and liver cancer. However, little is known about the correlation of salivary N-linked glycans related to HBV-infected liver diseases. Here we investigated N-linked glycome in saliva from 200 subjects (50 healthy volunteers (HV), 40 HBV-infected patients (HB), 50 cirrhosis patients (HC), and 60 hepatocellular carcinoma patients (HCC) using MALDI-TOF/TOF-MS...
April 8, 2017: Glycoconjugate Journal
https://www.readbyqxmd.com/read/28381457/a-novel-biomarker-associated-with-distress-in-humans-calcium-binding-protein-spermatid-specific-1-cabs1
#8
Thomas Ritz, David Rosenfield, Chris D St Laurent, Ana F Trueba, Chelsey A Werchan, Pia D Vogel, Richard J Auchus, Eduardo Reyes-Serratos, A Dean Befus
BACKGROUND: Calcium binding protein, spermatid specific 1 (CABS1) is expressed in human submandibular gland and has an anti-inflammatory motif similar to that in submandibular rat 1 (SMR1) in rats. Here we investigate CABS1 in human saliva and its association with psychological and physiological distress and inflammation in humans. METHOD: Volunteers participated across three studies: weekly baseline measures; a psychosocial speech and mental arithmetic stressor under evaluative threat; and during academic exam stress...
April 5, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/28376975/smoking-behavior-and-exposure-results-of-a-menthol-cigarette-cross-over-study
#9
Christina Vaughan Watson, Patricia Richter, B Rey de Castro, Connie Sosnoff, Jennifer Potts, Pamela Clark, Joan McCraw, Xizheng Yan, David Chambers, Clifford Watson
OBJECTIVE: Our objective was to improve understanding of the differences in use behavior and exposure when smoking menthol and non-menthol cigarettes using a 2-part cross-over design. METHODS: Adult daily smokers were assigned randomly to alternate between 2 weeks of exclusively smoking a menthol test cigarette or a non-menthol test cigarette. Urine and saliva were collected for biomarker measurements; carbon monoxide (CO) was measured, and participants smoked test cigarettes through a CreSS® smoking topography device during 3 clinic visits...
May 1, 2017: American Journal of Health Behavior
https://www.readbyqxmd.com/read/28375882/salivary-cortisol-and-cortisone-in-the-clinical-setting
#10
Joanne Blair, Jo Adaway, Brian Keevil, Richard Ross
PURPOSE OF REVIEW: A resurgence of interest in salivary biomarkers has generated evidence for their value in assessing adrenal function. The advantages of salivary measurements include only free hormone is detected, samples can be collected during normal daily routines and stress-induced cortisol release is less likely to occur than during venepuncture. We review the use of salivary biomarkers to diagnose and monitor patients for conditions of cortisol excess and deficiency and discuss the value of measuring salivary cortisone versus salivary cortisol...
April 3, 2017: Current Opinion in Endocrinology, Diabetes, and Obesity
https://www.readbyqxmd.com/read/28371361/-identification-of-salivary-protein-biomarkers-for-orthodontically-induced-inflammatory-root-resorption
#11
Karolina Elżbieta Kaczor-Urbanowicz, Omer Deutsch, Batia Zaks, Guy Krief, Stella Chaushu, Aaron Palmon
INTRODUCTION: Orthodontically induced inflammatory root resorption (OIIRR) is one of the most prevalent and unavoidable consequence of orthodontic tooth movement. The aim of this study was to discover potential diagnostic protein biomarkers for detection of OIIRR in whole saliva (WS). METHODS AND MATERIAL: Unstimulated WS was collected from 72 subjects: 48 OIIRR patients and 24 untreated, generally healthy, age and gender matched controls. Radiographic assessment of periapical X-Rays of 4 upper incisors taken before and 9 months after bonding was done...
March 29, 2017: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/28365944/mutual-information-network-based-support-vector-machine-strategy-identifies-salivary-biomarkers-in-gastric-cancer
#12
Yu-Gang Xu, Ming Cheng, Xia Zhang, Shi-Hai Sun, Wei-Min Bi
PURPOSE: To determine the vital salivary transcriptomic biomarkers for the early detection of gastric cancer via comparing classification efficiency of multiple candidate genes. METHODS: We firstly identified 5 kinds of candidate genes related to gastric cancer, including differential pathway genes (DPGs) based on the attract method, hub genes in differential pathways based on mutual information network (MIN) analysis, differentially expressed genes (DEGs) identified by Significance Analysis of Microarrays (SAM), informative genes (DEGs in differential pathways), and key genes (hub DEGs)...
January 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28347886/immunohistochemical-expression-of-epithelial-cell-adhesion-molecule-epcam-in-mucoepidermoid-carcinoma-compared-to-normal-salivary-gland-tissues
#13
Noura M Kamal, Hend M Salem, Heba M Dahmoush
OBJECTIVES: Mucoepidermoid carcinoma (MEC) is the most common malignant salivary gland tumor which displays biological, histological and clinical diversity thus representing a challenge for its diagnosis and management. Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein identified as a tumor specific antigen due to its frequent overexpression in the majority of epithelial carcinomas and its correlation with prognosis. It is considered to be a promising biomarker used as a therapeutic target already in ongoing clinical trials...
March 21, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28342734/integration-of-microbiome-and-epigenome-to-decipher-the-pathogenesis-of-autoimmune-diseases
#14
REVIEW
Beidi Chen, Luxi Sun, Xuan Zhang
The interaction between genetic predisposition and environmental factors are of great significance in the pathogenesis and development of autoimmune diseases (AIDs). The human mucosa is the most frequent site that interacts with the exterior environment, and commensal microbiota at the gut and other human mucosal cavities play a crucial role in the regulation of immune system. Growing evidence has shown that the compositional and functional changes of mucosal microbiota are closely related to AIDs. Gut dysbiosis not only influence the expression level of Toll-like receptors (TLRs) of antigen presenting cells, but also contribute to Th17/Treg imbalance...
March 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28339625/cystatin-s-a-candidate-biomarker-for-severity-of-submandibular-gland-involvement-in-sj%C3%A3-gren-s-syndrome
#15
Daniela Martini, Alessia Gallo, Serena Vella, Francesca Sernissi, Antonella Cecchettini, Nicoletta Luciano, Enza Polizzi, Pier Giulio Conaldi, Marta Mosca, Chiara Baldini
Objectives.: Salivary cystatin S is a defence protein mainly produced by submandibular glands and involved in innate oral immunity. This study aimed to verify whether cystatin S was diversely expressed in different disease subsets of primary Sjogren's syndrome (pSS) patients, defined on the basis of salivary flow [unstimulated salivary flow rate (USFR)], minor salivary gland (MSG) focus score and submandibular gland ultrasonography abnormalities. We also evaluated miR-126 and miR-335-5p expression in MSG biopsies to verify whether an aberrant regulation of cystatin S at the glandular level may influence its salivary expression...
February 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28337601/the-cortisol-awakening-response-mediates-the-relationship-between-acculturative-stress-and-self-reported-health-in-mexican-americans
#16
Antonio F Garcia, Kristin Wilborn, Deborah L Mangold
BACKGROUND: The assessment of acculturative stress as synonymous with acculturation level overlooks the dynamic, interactive, and developmental nature of the acculturation process. An individual's unique perception and response to a range of stressors at each stage of the dynamic process of acculturation may be associated with stress-induced alterations in important biological response systems that mediate health outcomes. Evidence suggests the cortisol awakening response (CAR) is a promising pre-clinical biomarker of stress exposure that may link acculturative stress to self-reported health in Mexican Americans...
March 23, 2017: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/28324703/arousal-amplifies-biased-competition-between-high-and-low-priority-memories-more-in-women-than-in-men-the-role-of-elevated-noradrenergic-activity
#17
David Clewett, Michiko Sakaki, Ringo Huang, Shawn E Nielsen, Mara Mather
Recent findings indicate that emotional arousal can enhance memory consolidation of goal-relevant stimuli while impairing it for irrelevant stimuli. According to one recent model, these goal-dependent memory tradeoffs are driven by arousal-induced release of norepinephrine (NE), which amplifies neural gain in target sensory and memory processing brain regions. Past work also shows that ovarian hormones modulate activity in the same regions thought to support NE's effects on memory, such as the amygdala, suggesting that men and women may be differentially susceptible to arousal's dual effects on episodic memory...
February 24, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28319898/immunodetection-of-salivary-biomarkers-by-an-optical-microfluidic-biosensor-with-polyethylenimine-modified-polythiophene-c70-organic-photodetectors
#18
Tao Dong, Nuno Miguel Matos Pires
This work reports a novel optical microfluidic biosensor with highly sensitive organic photodetectors (OPDs) for absorbance-based detection of salivary protein biomarkers at the point of care. The compact and miniaturized biosensor has comprised OPDs made of polythiophene-C70 bulk heterojunction for the photoactive layer; whilst a calcium-free cathode interfacial layer, made of linear polyethylenimine, was incorporated to the photodetectors to enhance the low cost. The OPDs realized onto a glass chip were aligned to antibody-functionalized chambers of a poly(methyl methacrylate) microfluidic chip, in where immunogold-silver assays were conducted...
March 6, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28318170/-application-of-saliva-in-disease-diagnosis
#19
REVIEW
Cheng Xingqun, Zhou Xuedong, Xu Xin
Saliva is secreted by salivary glands and performs a variety of functions, including mouth cleaning and protection, antibacterial activity, and digestion. With the rapid progress in salivaomics, saliva became recognized as a potential pool of biological markers. Being a non-invasive and safe source, saliva is a potential substitute for blood in diagnosis and prognosis of diseases. This review summarizes the latest advancement in saliva-related studies and presents the potential value of saliva in early diagnosis of oral diseases, such as dental caries, periodontal disease, cancer, diabetes, and other systemic disorders...
December 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28315649/comparison-of-saliva-collection-methods-for-the-determination-of-salivary-cortisol-levels-in-rhesus-macaques-macaca-mulatta-cynomolgus-macaques-macaca-fascicularis-and-african-green-monkeys-chlorocebus-aethiops
#20
Kamala J Rapp-Santos, Louis A Altamura, Sarah L Norris, Luis A Lugo-Roman, Pedro J Rico, Christian C Hofer
The ability to quickly and accurately determine cortisol as a biomarker for stress is a valuable tool in assessing the wellbeing of NHP. In this study, 2 methods of collecting saliva (a commercial collection device and passive drool) and the resulting free salivary cortisol levels were compared with total serum cortisol concentration in rhesus macaques (Macaca mulatta), cynomolgus macaques (Macaca fascicularis) and African green monkeys (Chlorocebus aethiops) at 2 collection time points. Serum and salivary cortisol levels were determined using a competitive quantitative ELISA...
March 1, 2017: Journal of the American Association for Laboratory Animal Science: JAALAS
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