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Salivary biomarkers

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https://www.readbyqxmd.com/read/29763839/salivary-fingerprint-of-simple-obesity
#1
Anna Lehmann-Kalata, Izabela Miechowicz, Katarzyna Korybalska, Ewelina Swora-Cwynar, Natasza Czepulis, Joanna Łuczak, Zofia Orzechowska, Marian Grzymisławski, Anna Surdacka, Janusz Witowski
BACKGROUND: The nature of a link between poor oral health and obesity is not fully understood. It is also unclear if saliva contributes to it and whether the properties of saliva change as a result of an increase in body mass or rather as a consequence of obesity-associated comorbidities. This pilot study was undertaken in an attempt to determine if salivary biomarkers can identify obesity per se. METHODS: Whole mixed saliva was analysed for 16 soluble parameters covering 4 categories (inflammation, oxidative stress, endothelial dysfunction, adipokines)...
May 11, 2018: Cytokine
https://www.readbyqxmd.com/read/29754884/circulating-salivary-mirna-hsa-mir-221-as-clinically-validated-diagnostic-marker-for-hand-foot-and-mouth-disease-in-pediatric-patients
#2
Nyo Min, Previtha Dawn Sakthi Vale, Anng Anng Wong, Natalie Woon Hui Tan, Chia Yin Chong, Chih-Jung Chen, Robert Y L Wang, Justin Jang Hann Chu
Enhancements in the diagnostic capabilities using host biomarkers are currently much needed where sensitivity and specificity issues plague the diagnosis of Hand, Foot and Mouth Disease (HFMD) in pediatrics clinical samples. We investigated miRNome profiles of HFMD saliva samples against healthy children and developed miRNA-based diagnosis models. Our 6-miRNA scoring model predicted HFMD with an overall accuracy of 85.11% in the training set and 92.86% in the blinded test set of Singapore cohort. Blinded evaluation of the model in Taiwan HFMD cases resulted in 77...
May 10, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29752756/soluble-urokinase-type-plasminogen-activator-receptor-is-associated-with-signs-of-periodontitis-in-adolescents
#3
Peter D Skottrup, Gunnar Dahlén, Vibeke Baelum, Rodrigo Lopez
Owing to its molecular stability in body fluids, soluble urokinase-type plasminogen activator receptor (suPAR) is used as a biomarker for the level of systemic inflammation. This study compares the suPAR levels in serum with those in the saliva of adolescents and evaluates their association with the periodontal conditions. Adolescents identified as screen positive (n = 87) or screen negative (n = 73) for periodontitis had saliva and serum samples taken, along with subgingival plaque samples. The concentrations of suPAR were determined in saliva and serum, and 18 microbial species and the immunoglobulin response to them was evaluated...
May 11, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29750386/saliva-in-the-omics-era-a-promising-tool-in-paediatrics
#4
Eftychia Pappa, Eleni Kousvelari, Heleni Vastardis
In vulnerable populations, such as infants and children, saliva makes the perfect diagnostic medium because of its non-invasive collection, easy handling and storage of samples. Its unique biomarker profiles help tremendously in the diagnosis of many diseases and conditions. In fact, saliva genomics, proteomics, transcriptomics, metabolomics and microbiome-based discoveries have led to complementary and powerful diagnostic information. In children and neonates, saliva is the preferred medium not only for diagnosis of caries and aggressive periodontitis but also for a number of systemic conditions, metabolic diseases, cognitive functions, stress assessment and evaluation of immunological and inflammatory responses to vaccination...
May 11, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29747642/salivary-alpha-amylase-activity-and-cortisol-in-horses-with-acute-abdominal-disease-a-pilot-study
#5
María Dolores Contreras-Aguilar, Damián Escribano, María Martín-Cuervo, Fernando Tecles, Jose Joaquín Cerón
BACKGROUND: The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biomarker, in horses with acute abdominal disease. Therefore, a prospective observational study was performed in which both biomarkers were analyzed in a group of horses with acute abdomen syndrome, and compared with a group of healthy control horses by an unpaired Student's t-test...
May 10, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29744196/salivary-mmp-13-gender-differences-in-periodontitis-a-cross-sectional-study-from-sweden
#6
Eunice Virtanen, Maha Yakob, Taina Tervahartiala, Per-Östen Söder, Leif C Andersson, Timo Sorsa, Jukka H Meurman, Birgitta Söder
We investigated serum and saliva concentrations of matrix metalloproteinases, MMP-8, MMP-9, and MMP-13, and their tissue inhibitor TIMP-1, in a group of patients with and without periodontitis from Sweden. The hypothesis was that these biomarkers are higher in the periodontitis patients. Ninety patients participated in this cross-sectional study. Fifty-one patients had periodontitis whereas 39 were periodontally healthy. Saliva and serum samples were analyzed with immunofluorometric, enzyme-linked immunosorbent assay and western blot...
October 2017: Clinical and Experimental Dental Research
https://www.readbyqxmd.com/read/29743609/salivary-levels-of-total-huntingtin-are-elevated-in-huntington-s-disease-patients
#7
Jody Corey-Bloom, Ameera S Haque, Sungmee Park, Ajay S Nathan, Robert W Baker, Elizabeth A Thomas
Patients with Huntington's disease (HD), an autosomal-dominant neurodegenerative disease, show substantial variability in age-of-onset, symptom severity and course of illness, warranting the need for biomarkers to anticipate and monitor these features. The HD gene encodes the disease protein huntingtin (Htt), a potentially useful biomarker for this disease. In the current study, we determined whether total Htt protein (normal plus mutant; "tHtt") could be reliably measured in human saliva, a body fluid that is much more accessible compared to cerebral spinal fluid or even blood, and whether salivary levels of tHtt were clinically meaningful...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29740515/il-6-and-tnf-%C3%AE-salivary-levels-according-to-the-periodontal-status-in-portuguese-pregnant-women
#8
Vanessa Machado, Maria Fernanda Mesquita, Maria Alexandra Bernardo, Ester Casal, Luís Proença, José João Mendes
Background: Periodontitis is associated with increased concentration of inflammatory markers and saliva has been proposed as a non-invasive diagnostic fluid in oral and systemic diseases. The levels of salivary biomarkers, such as cytokines, could potentially be used to distinguish periodontal healthy individuals from subjects with periodontal disease. The purpose of this study was to characterize the salivary levels of two inflammatory biomarkers associated with periodontitis, interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α), in order to assess whether these cytokines salivary levels could potentially be used to complement periodontitis pregnant women diagnose...
2018: PeerJ
https://www.readbyqxmd.com/read/29734861/establishment-and-characterization-of-a-carcinoma-associated-fibroblast-cell-line-derived-from-a-human-salivary-gland-adenoid-cystic-carcinoma
#9
Jing Kong, Han Zhao, Qianhui Shang, Zhifei Ma, Ni Kang, Junling Tan, Hyat Ahmed Ibrahim Alraimi, Tingjiao Liu
Salivary gland adenoid cystic carcinoma (SACC) is one of the most common malignancies in the oral and maxillofacial region. Carcinoma-associated fibroblast (CAF) is an important component in the tumor microenvironment and participates in SACC progression. In this study, we established a CAF cell line derived from a human SACC and named it CAF-SA. It was identified that CAF-SA expressed typical CAF biomarkers. Then, we studied the cellular communications between CAF-SA, tumor cells and endothelial cells. It was found that CAF-SA promoted the migration, invasion, and proliferation of SACC tumor cells in vitro...
December 2018: Cell Communication & Adhesion
https://www.readbyqxmd.com/read/29733496/children-s-stress-related-reports-and-stress-biomarkers-interact-in-their-association-with-metabolic-syndrome-risk
#10
Nathalie Michels, Dante Matthys, Barbara Thumann, Staffan Marild, Stefaan De Henauw
The purpose was to examine the cross-sectional associations of stress-related reports and stress biomarkers with metabolic syndrome (MetS) risk in children while also testing the interaction between stress biomarkers and stress reports. In 353 children (5-10 years old, 7.9% overweight/obese), MetS risk was measured by blood pressure, waist circumference, glucose homeostasis, triglycerides, and high-density cholesterol. Stress was measured by stress-related reports (events, emotions, and internalizing/externalizing problems) and two biomarkers: salivary cortisol (total-day and morning output) and heart rate variability (percentage of consecutive normal RR intervals differing more than 50 ms and low-to-high-frequency ratio)...
May 7, 2018: Stress and Health: Journal of the International Society for the Investigation of Stress
https://www.readbyqxmd.com/read/29721505/salivary-biomarkers-in-systemic-sclerosis-disease
#11
REVIEW
Zeineb Zian, Joaira Bakkach, Amina Barakat, Naima Ghailani Nourouti, Mohcine Bennani Mechita
Scleroderma or systemic sclerosis (SSc) is frequently detected at an advanced stage due to diagnosis difficulties. Salivary biomarkers, if existing, could be used for predictive diagnosis of this disease. Human saliva contains a large number of proteins that can be used for diagnosis and are of great potential in clinical research. The use of proteomic analysis to characterize whole saliva (WS) in SSc has gained an increasing attention in the last years and the identification of salivary proteins specific for SSc could lead to early diagnosis or new therapeutic targets...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29721173/salivary-micrornas-as-new-molecular-markers-in-cleft-lip-and-palate-a-new-frontier-in-molecular-medicine
#12
Vincenzo Grassia, Angela Lombardi, Hiromichi Kawasaki, Carmela Ferri, Letizia Perillo, Laura Mosca, Donatella Delle Cave, Ludovica Nucci, Marina Porcelli, Michele Caraglia
MicroRNAs (miRNAs) are endogenous non-coding RNAs of about twenty-two nucleotides that regulate gene expression through post-transcriptional control. The purpose of the present study was to identify and describe the salivary miRNAs in cleft lip and palate (CLP) patients comparing them with a control healthy group. Twelve patients (mean age 11.9 ± 2.42 years; 6M/6F) formed the study group. The control group was created selecting twelve healthy subjects matched for age and sex with study group. We recorded differences in miRNA expression profile between the saliva of CLP patients and the control group...
April 10, 2018: Oncotarget
https://www.readbyqxmd.com/read/29706798/rooming-in-reduces-salivary-cortisol-level-of-newborn
#13
Giuseppe De Bernardo, Marina Riccitelli, Maurizio Giordano, Fabrizio Proietti, Desiree Sordino, Mariangela Longini, Giuseppe Buonocore, Serafina Perrone
Background: Rooming-in practice improves breastfeeding and reduces newborn stress reactivity. When this modality is not available, partial rooming-in after birth can be considered. Salivary cortisol levels (SCLs) are considered reliable biomarkers to indicate stress. Objective: To test the hypothesis that rooming-in duration impacts neonatal stress response in hospitalized newborns. Design/methods: Forty term newborns, enrolled in the Neonatology and Obstetrics Nursing, C...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29703661/inflammatory-biomarkers-in-individuals-at-clinical-high-risk-for-psychosis-chr-p-state-or-trait
#14
REVIEW
Rita Khoury, Henry A Nasrallah
BACKGROUND: Studies linking neuro-inflammation to psychotic episodes has been rapidly expanding. Assessments of changes in inflammatory biomarkers in prodromal patients who subsequently convert to psychosis may help in predicting those likely to transition to psychosis. METHODS: We reviewed the literature for original studies that measured inflammatory biomarkers in individuals at clinical high risk for psychosis (CHR-P), and compared pro-inflammatory biomarker data between converters and non-converters to psychosis as well as in healthy controls...
April 24, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29694317/psychophysiological-response-to-social-stressors-relevance-of-sex-and-age
#15
Matias M Pulopulos, Vanesa Hidalgo, Sara Puig-Pérez, Alicia Salvador
BACKGROUND: Understanding the factors involved in the psychophysiological response of people in acute stressful situations is crucial to the prevention and treatment of stress-related health problems. We aim to integrate the results of studies investigating the role of sex and age in the inter-individual variability in several biomarkers of the stress response. METHODS: We summarize the main findings of our research group and other laboratories regarding sex and age-related differences in the psychophysiological response to psychosocial stress...
May 2018: Psicothema
https://www.readbyqxmd.com/read/29685897/characterization-of-human-salivary-extracellular-rna-by-next-generation-sequencing
#16
Feng Li, Karolina Elżbieta Kaczor-Urbanowicz, Jie Sun, Blanca Majem, Hsien-Chun Lo, Yong Kim, Kikuye Koyano, Shannon Liu Rao, So Young Kang, Su Mi Kim, Kyoung-Mee Kim, Sung Kim, David Chia, David Elashoff, Tristan R Grogan, Xinshu Xiao, David T W Wong
BACKGROUND: It was recently discovered that abundant and stable extracellular RNA (exRNA) species exist in bodily fluids. Saliva is an emerging biofluid for biomarker development for noninvasive detection and screening of local and systemic diseases. Use of RNA-Sequencing (RNA-Seq) to profile exRNA is rapidly growing; however, no single preparation and analysis protocol can be used for all biofluids. Specifically, RNA-Seq of saliva is particularly challenging owing to high abundance of bacterial contents and low abundance of salivary exRNA...
April 23, 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29683364/inflammatory-biomarkers-in-saliva-and-serum-of-patients-with-rheumatoid-arthritis-with-respect-to-periodontal-status
#17
Leena Äyräväinen, Anna Maria Heikkinen, Antti Kuuliala, Kirsi Ahola, Riitta Koivuniemi, Leena Laasonen, Eeva Moilanen, Mari Hämäläinen, Taina Tervahartiala, Jukka H Meurman, Marjatta Leirisalo-Repo, Timo Sorsa
OBJECTIVE: To study prospectively the association of salivary and serum matrix metalloproteinase (MMP)-8, tissue inhibitor of MMPs (TIMP)-1 and interleukin (IL)-6 with periodontal and systemic inflammation in rheumatoid arthritis (RA). We hypothesized that biomarker concentrations reflect inflammation. METHODS: 53 early untreated RA (ERA) and 28 chronic RA (CRA) patients, underwent rheumatological and dental examinations at baseline and one year later after starting first conventional or biological disease modifying antirheumatic drug...
April 23, 2018: Annals of Medicine
https://www.readbyqxmd.com/read/29669525/salivary-extracellular-vesicle-associated-mirnas-as-potential-biomarkers-in-oral-squamous-cell-carcinoma
#18
Chiara Gai, Francesco Camussi, Roberto Broccoletti, Alessio Gambino, Marco Cabras, Luca Molinaro, Stefano Carossa, Giovanni Camussi, Paolo G Arduino
BACKGROUND: Several studies in the past have investigated the expression of micro RNAs (miRNAs) in saliva as potential biomarkers. Since miRNAs associated with extracellular vesicles (EVs) are known to be protected from enzymatic degradation, we evaluated whether salivary EVs from patients with oral squamous cell carcinoma (OSCC) were enriched with specific subsets of miRNAs. METHODS: OSCC patients and controls were matched with regards to age, gender and risk factors...
April 18, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29621567/salivary-biomarkers-of-inflammation-in-systemic-lupus-erythematosus
#19
Iulia-Ioana Stanescu, Bogdan Calenic, Alina Dima, Livia Alexandra Gugoasa, Eugenia Balanescu, Raluca-Ioana Stefan van Staden, Cristian Baicus, Daniela Gabriela Badita, Maria Greabu
Saliva is currently used as a reliable diagnostic fluid in a wide range of local and systemic diseases. However, the link between salivary diagnosis and the inflammatory process in autoimmune diseases has not yet been explored. The aim of our study is to assess possible correlations between salivary inflammatory markers and systemic lupus erythematosus (SLE). Patients fulfilling the Systemic Lupus International Collaborating Clinics (SLICC) diagnosis criteria were included. Salivary and serum levels of interleukin-6 (IL-6), leptin, monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) were determined using stochastic sensors...
April 2, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29615776/dysbiosis-of-the-salivary-microbiota-in-pediatric-onset-primary-sclerosing-cholangitis-and-its-potential-as-a-biomarker
#20
Kentaro Iwasawa, Wataru Suda, Tomoyuki Tsunoda, Manari Oikawa-Kawamoto, Shuichiro Umetsu, Lena Takayasu, Ayano Inui, Tomoo Fujisawa, Hidetoshi Morita, Tsuyoshi Sogo, Masahira Hattori
Primary sclerosing cholangitis (PSC) is a liver disease known for its frequent concurrence with inflammatory bowel disease. Dysbiosis of the gut microbiota in PSC was reported in several studies, but the microbiological features of the salivary microbiota in PSC have not been established. Here we compared the salivary microbial communities of 24 pediatric-onset PSC patients, 16 age-matched ulcerative colitis (UC) patients, and 24 healthy controls (HCs) by analyzing the bacterial 16S rRNA gene sequence data...
April 3, 2018: Scientific Reports
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