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Salivary biomarkers

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https://www.readbyqxmd.com/read/28549179/relationships-between-smoking-behaviors-and-cotinine-levels-among-two-american-indian-populations-with-distinct-smoking-patterns
#1
Julie-Anne Tanner, Jeffrey A Henderson, Dedra Buchwald, Barbara V Howard, Patricia Nez Henderson, Rachel F Tyndale
Introduction: Smoking prevalence, cigarettes per day (CPD), and lung cancer incidence differ between Northern Plains (NP) and Southwestern (SW) American Indian populations. We used cotinine as a biomarker of tobacco smoke exposure to biochemically characterize NP and SW smokers and non-smokers, and to investigate factors associated with variation in tobacco exposure. Methods: American Indians (N=636) were recruited from two different tribal populations (NP and SW) as part of a study conducted as part of the Collaborative to Improve Native Cancer Outcomes P50 project...
May 26, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28545132/proteomics-investigation-of-oscc-specific-salivary-biomarkers-in-a-hungarian-population-highlights-the-importance-of-identification-of-population-tailored-biomarkers
#2
Éva Csősz, Péter Lábiscsák, Gergő Kalló, Bernadett Márkus, Miklós Emri, Adrienn Szabó, Ildikó Tar, József Tőzsér, Csongor Kiss, Ildikó Márton
Oral squamous cell carcinoma (OSCC) accounting for about 90% of malignant oral lesions is the 6th most common malignancy worldwide. Diagnostic delay may contribute to dismal survival rate therefore, there is a need for developing specific and sensitive biomarkers to improve early detection. Hungarian population occupies the top places of statistics regarding OSCC incidence and mortality figures therefore, we aimed at finding potential salivary protein biomarkers suitable for the Hungarian population. In this study we investigated 14 proteins which were previously reported as significantly elevated in saliva of patients with OSCC...
2017: PloS One
https://www.readbyqxmd.com/read/28542739/afternoon-cortisol-provides-a-link-between-self-regulated-anger-and-peer-reported-aggression-in-typically-developing-children-in-the-school-context
#3
Eva Oberle, Kaitlyn McLachlan, Nicole L A Catherine, Ursula Brain, Kimberly A Schonert-Reichl, Joanne Weinberg, Tim F Oberlander
Aggression jeopardizes positive development in children and predicts social and academic maladjustment in school. The present study determined the relationships among anger dysregulation (a marker of emotion regulation), cortisol activity (a biomarker of stress), and peer-nominated aggression in typically developing children in their everyday classroom setting (N = 151, Mean age = 10.86, SD =.74). Salivary cortisol was collected at 09:15, 11:45, and 14:45 hr across 4 consecutive days. Children provided self-reports of anger regulation; peers reported proactive and reactive aggressive behaviors...
May 22, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28532233/updates-on-sj%C3%A3-gren-s-syndrome-from-proteomics-to-protein-biomarkers
#4
Chiara Baldini, Antonella Cecchettini, Alessia Gallo, Stefano Bombardieri
Primary Sjögren's syndrome (pSS) is a complex heterogeneous autoimmune disorder, typically affecting exocrine glands. Recently, a great interest has arisen in searching for novel biomarkers able to improve the diagnostic work-up of the disease as well as the general assessment and the prognostic stratification of pSS patients. From this perspective, salivary proteomics has appeared as a promising tool considering that salivary proteins may closely reflect the underlying disease processes in the salivary glands...
May 26, 2017: Expert Review of Proteomics
https://www.readbyqxmd.com/read/28530434/associations-between-observed-parenting-behavior-and-adolescent-inflammation-two-and-a-half-years-later-in-a-community-sample
#5
Michelle L Byrne, Sally Horne, Neil M O'Brien-Simpson, Katrina A Walsh, Eric C Reynolds, Orli S Schwartz, Sarah Whittle, Julian G Simmons, Lisa Sheeber, Nicholas B Allen
OBJECTIVE: Family environments have an effect on physical health during adolescence, and a possible underlying mechanism is inflammation. However, little is known about the association between observed parenting behaviors and immune system functioning. The current study examined whether positive and negative emotional parental behaviors observed during family interactions were associated with inflammation in adolescents. METHOD: Sixty-one parent-adolescent dyads (37 male adolescents, 60...
May 22, 2017: Health Psychology: Official Journal of the Division of Health Psychology, American Psychological Association
https://www.readbyqxmd.com/read/28523434/salivary-exosomal-psma7-a-promising-biomarker-of-inflammatory-bowel-disease
#6
Xiaowen Zheng, Feng Chen, Qian Zhang, Yulan Liu, Peng You, Shan Sun, Jiuxiang Lin, Ning Chen
Inflammatory bowel disease (IBD) is an intestinal immune-dysfunctional disease worldwide whose prevalence increasing in Asia including China. It is a chronic disease of the gastrointestinal tract with unknown cause. Exosomes are small vesicles in various body fluids. They have diameters of 40-120 nm, and one of their functions is long-distance transfer of various substances. In this study, we investigated the contents of salivary exosomes in patients with IBD and in healthy controls to explore a new biomarker in patients with IBD...
May 18, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28523411/apurinic-apyrimidinic-endonuclease-1-ape1-is-overexpressed-in-malignant-transformation-of-salivary-gland-pleomorphic-adenoma
#7
Leorik Pereira Silva, Thalita Santana, Bruno Tavares Sedassari, Suzana Machado de Sousa, Ana Paula Veras Sobral, Roseana de Almeida Freitas, Carlos Augusto Galvão Barboza, Lélia Batista de Souza
DNA repair systems play a critical role in protecting the human genome against cumulative damage. The apurinic/apyrimidinic endonuclease 1 is a protein involved in DNA base excision repair and its expression still needs to be investigated in salivary gland tumors. The objective of this study is to analyze the immunoexpression of apurinic/apyrimidinic endonuclease 1 in pleomorphic adenomas and carcinomas ex pleomorphic adenomas of the salivary glands. A total of 33 pleomorphic adenomas and 16 carcinomas ex pleomorphic adenomas of the salivary glands underwent immunohistochemical study by the polymeric biotin-free technique...
May 18, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28523257/comparative-evaluation-of-salivary-neopterin-levels-and-its-effects-to-periodontal-therapy-in-pre-and-post-menopausal-women
#8
Jammula Surya Prasanna, Chinta Sumadhura, Parupalli Karunakar, Naineni Rohini
OBJECTIVES: Neopterin is a valuable diagnostic biomarker, which is elevated in inflammatory conditions like periodontitis, that is characterized by destruction of the supporting structures of the teeth. Among the biomarkers, neopterin occurs in body fluids, and acts as a diagnostic marker for present and future disease activity. METHODS: Thirty female subjects with chronic periodontitis, mean age 50 years (40-60 years) were included in this study. Depending upon their menstrual history, subjects were categorized into two groups of fifteen each...
April 2017: Journal of Menopausal Medicine
https://www.readbyqxmd.com/read/28521309/care-transitions-and-adult-day-services-moderate-the-longitudinal-links-between-stress-biomarkers-and-family-caregivers-functional-health
#9
Yin Liu, David M Almeida, Michael J Rovine, Steven H Zarit
BACKGROUND: Stress biomarkers have been linked to health and well-being. There are, however, few studies on how dysregulation in the hypothalamic-pituitary-adrenal axis and sympathetic nervous system actually affects functional health of family caregivers of persons with dementia. Further, it is not clear whether and how factors affecting caregiving stressor exposures such as care transitions and adult day services (ADS) use may affect such association. OBJECTIVE: First, to examine the association of daily stress biomarkers and functional health over time among family caregivers of persons with dementia...
May 19, 2017: Gerontology
https://www.readbyqxmd.com/read/28516971/salivary-biomarkers-and-proteomics-future-diagnostic-and-clinical-utilities
#10
M Castagnola, E Scarano, G C Passali, I Messana, T Cabras, F Iavarone, G Di Cintio, A Fiorita, E De Corso, G Paludetti
Saliva testing is a non-invasive and inexpensive test that can serve as a source of information useful for diagnosis of disease. As we enter the era of genomic technologies and -omic research, collection of saliva has increased. Recent proteomic platforms have analysed the human salivary proteome and characterised about 3000 differentially expressed proteins and peptides: in saliva, more than 90% of proteins in weight are derived from the secretion of three couples of "major" glands; all the other components are derived from minor glands, gingival crevicular fluid, mucosal exudates and oral microflora...
April 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/28512552/ability-of-salivary-biomarkers-in-the-prognostic-of-systemic-and-buccal-inflammation
#11
REVIEW
Aida Gutiérrez-Corrales, Elena Campano-Cuevas, Gabriel Castillo-Dalí, Daniel Torres-Lagares, José-Luis Gutiérrez-Pérez
Nowadays, there is a growing interest in using saliva as an alternative sample for the diagnosis, prediction and progression of several diseases. It has been established that some molecules found in saliva are related to oral inflammatory processes and systemic health status. Furthermore, it is known that saliva is crucial for the carrying out of different functions in the oral cavity and its role in the local modulation of inflammatory and immune response is being thoroughly studied by the health research community...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28512281/intricate-assessment-and-evaluation-of-long-term-implant-success-as-affected-by-clinicomicrobial-and-salivary-diagnostics-in-type-ii-diabetic-patients-a-longitudinal-study
#12
Deepti Raghav, Fawaz Alqahtani, Fatima J Albaker, Tushar V Bhagat, Zaheer Kola
INTRODUCTION: Replacement of missing teeth by dental implants is one of the most common methods employed these days. Because of significant advancement in the design of implants and modifications in the procedure of dental implant surgery, the survival rate of the dental implants has reached up to approximately 95%. Osseointegration is one of the important factors affecting the survival of dental implants. Apart from these, the body's physiologic alterations can also predispose the dental implants for failure...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28511885/salivary-changes-in-type-2-diabetic-patients
#13
Sabah E Abd-Elraheem, Amany Mohammed El Saeed, Hayam Hamza Mansour
OBJECTIVE: this study was conducted to determine the effect of type 2 diabetes mellitus on salivary secretion of glucose, amylase and immunoglobulin A levels and also to fined out if saliva could be used as anon invasive method to monitor glycaemic control in type 2 diabbetes. This study was conducted on 40 human subjectes, They were 20 males and 20 females, their ages ranged from 35 years to 64 years,and they were divided into two groups, the first one is the patient group which contains 20 diabetic paient...
April 23, 2017: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/28505199/stress-and-salivary-cortisol-in-emergency-medical-dispatchers-a-randomized-shifts-control-trial
#14
Sarah Bedini, François Braun, Laurence Weibel, Michel Aussedat, Bruno Pereira, Frédéric Dutheil
Stress at work is a public health concern. Phone operators in emergency medical dispatch centers are particularly at risk. We aimed to demonstrate that the most stressful time for emergency medical dispatchers is the shift when they receive emergency incoming calls, with cortisol as a biomarker of stress. For each emergency medical dispatcher, we measured outcomes over a control day and during three types of shift: Incoming emergency call, Dispatch and Re-assessment. The pattern of shifts was randomized. Saliva was sampled every 15 minutes for 2 hours, i...
2017: PloS One
https://www.readbyqxmd.com/read/28502067/predictive-value-of-salivary-microrna-320a-vascular-endothelial-growth-factor-receptor-2-crp-and-il-6-in-oral-lichen-planus-progression
#15
Minoo Shahidi, Soudeh Jafari, Mahmood Barati, Masoumeh Mahdipour, Mohammad Saeed Gholami
INTRODUCTION: MicroRNA (miRNA) 320a and vascular endothelial growth factor receptor 2 (VEGFR-2) expression as the angiogenic biomarkers might be therapeutic targets in Oral lichen planus (OLP). IL-6 and C-reactive protein (CRP) could be prognostic in OLP, dysplastic OLP and Oral squamous cell carcinoma (OSCC). Therefore, their salivary detections as the noninvasive tools were aimed in this study. MATERIALS AND METHODS: Histopathologic examinations were carried out to distinguish the patients with dysplastic OLP and OSCC...
May 13, 2017: Inflammopharmacology
https://www.readbyqxmd.com/read/28484423/evaluation-of-salivary-cytokines-for-diagnosis-of-both-trauma-induced-and-genetic-heterotopic-ossification
#16
Hsiao Hsin Sung Hsieh, Michael T Chung, Ronald M Allen, Kavitha Ranganathan, Joe Habbouche, David Cholok, Jonathan Butts, Arminder Kaura, Ramkumar Tiruvannamalai-Annamalai, Chris Breuler, Caitlin Priest, Shawn J Loder, John Li, Shuli Li, Jan Stegemann, Steven L Kunkel, Benjamin Levi
PURPOSE: Heterotopic ossification (HO) occurs in the setting of persistent systemic inflammation. The identification of reliable biomarkers can serve as an early diagnostic tool for HO, especially given the current lack of effective treatment strategies. Although serum biomarkers have great utility, they can be inappropriate or ineffective in traumatic acute injuries and in patients with fibrodysplasia ossificans progressiva (FOP). Therefore, the goal of this study is to profile the cytokines associated with HO using a different non-invasive source of biomarkers...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/28475772/retirement-and-socioeconomic-differences-in-diurnal-cortisol-longitudinal-evidence-from-a-cohort-of-british-civil-servants
#17
Tarani Chandola, Patrick Rouxel, Michael G Marmot, Meena Kumari
Objectives: Early old age and the period around retirement are associated with a widening in socioeconomic inequalities in health. There are few studies that address the stress-biological factors related to this widening. This study examined whether retirement is associated with more advantageous (steeper) diurnal cortisol profiles, and differences in this association by occupational grade. Method: Data from the 7th (2002-2004), 8th (2006), and 9th (2007-09) phases of the London-based Whitehall II civil servants study were analysed...
May 5, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28474967/salivary-colony-stimulating-factor-1-interleukin-34-and-matrix-metalloproteinase-8-as-markers-of-periodontal-disease
#18
G L Martinez, M Majster, N Bjurshammar, A Johannsen, C M Figueredo, E A Boström
BACKGROUND: Colony-stimulating factor (CSF)-1 and interleukin (IL)-34 are macrophage growth factors and regulators of osteoclastogenesis. The potential involvement of CSF-1 and IL-34 in periodontal disease is yet unknown. The aim of this study was to explore the presence of CSF-1 and IL-34 in whole saliva in relation to periodontal disease. METHODS: Protocol validation was assessed in saliva of healthy donors (n=21) by ELISA. Salivary CSF-1, IL-34, and matrix metalloproteinase (MMP)-8, a biomarker candidate of periodontitis, were determined in 48 patients (29 periodontitis, 12 gingivitis, 7 healthy) and related to the clinical periodontal parameters bleeding on probing (BOP), probing depth (PD), clinical attachment loss (AL), and plaque index (PI)...
May 5, 2017: Journal of Periodontology
https://www.readbyqxmd.com/read/28473973/salivary-diagnostics-in-pediatrics-applicability-translatability-and-limitations
#19
REVIEW
Mona Hassaneen, Jill L Maron
In the last decade, technological advances, combined with an improved appreciation of the ability of saliva to inform caregivers about both oral health and systemic disease, have led to the emergence of salivary diagnostic platforms. However, the majority of these assays have targeted diseases that more commonly affect the adult population, largely neglecting infants and children who arguably could benefit the most from non-invasive assessment tools for health monitoring. Gaining access into development, infection, and disease through comprehensive "omic" analyses of saliva could significantly improve care and enhance health access...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28460841/low-endogenous-fibroblast-growth-factor-2%C3%A2-levels-are-associated-with-heightened-conditioned-fear-expression-in-rats-and-humans
#20
Bronwyn M Graham, Dino Zagic, Rick Richardson
BACKGROUND: Hippocampal concentrations of the neurotrophic factor fibroblast growth factor 2 (FGF2) are negatively associated with the expression of fear following conditioning in rats. Heightened conditioned fear expression may be a prospective risk factor for the development of human anxiety and trauma disorders. However, the relationship between conditioned fear expression and FGF2 is yet to be established in humans. METHODS: Using a cross-species approach, we first investigated the relationship between serum concentrations of FGF2 and individual differences in conditioned fear expression in rats (n = 19)...
April 5, 2017: Biological Psychiatry
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