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Salivary biomarkers

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https://www.readbyqxmd.com/read/29149225/chemical-analysis-in-saliva-and-the-search-for-salivary-biomarkers-a-tutorial-review
#1
Kamonwad Ngamchuea, Korbua Chaisiwamongkhol, Christopher Batchelor-McAuley, Richard G Compton
Biomarkers refer to analytes that can be used in the diagnosis of diseases or disorders. In saliva, there are many components that are potential biomarkers, and increasing research has focussed on the development of saliva as a diagnostic fluid. This review summarizes the existing uses of salivary biomarkers and highlights the importance of the choice of saliva collection as well as the storage procedures. A case study on the effect of collection tools on the concentrations of one of the potential biomarkers, glutathione, is highlighted...
November 17, 2017: Analyst
https://www.readbyqxmd.com/read/29141753/serological-evaluation-of-cutaneous-leishmania-tropica-infection-in-northern-israel
#2
Iva Rohoušová, Dalit Talmi-Frank, Michaela Vlková, Tatiana Spitzová, Koranit Rishpon, Charles L Jaffe, Petr Volf, Gad Baneth, Moshe Efrat
Leishmania spp. are medically important unicellular parasites transmitted by phlebotomine sand flies. The World Health Organization recently highlighted the importance of reliable diagnostic tools for leishmaniasis. Our study of human infection was conducted in two endemic foci of Leishmania tropica in the Galilee region, northern Israel. Elevated anti-Leishmania antibodies were present in the majority (78.6%) of L. tropica-PCR positive individuals. Moreover, the enzyme-linked immunosorbent assay showed high sensitivity, specificity, and negative and positive predictive values (ranging between 73% and 79%), thus fulfilling the basic requirement for future development of a serodiagnostic and screening tool...
October 23, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29138754/the-relation-between-periodontopathogenic-bacterial-levels-and-resistin-in-the-saliva-of-obese-type-2-diabetic-patients
#3
Natheer Al-Rawi, Farah Al-Marzooq
This study aims to investigate the relation between resistin and periodontopathogenic bacterial levels in the saliva of obese adults compared to healthy control and to examine whether salivary resistin can serve as a biomarker of type 2 diabetes in obese patients. A total of 78 saliva samples were collected from patients attending to the University Dental Hospital, Sharjah, UAE. The patients were divided into three equal groups: obese diabetics, obese nondiabetics, and nonobese nondiabetic control. Salivary resistin was measured using ELISA...
2017: Journal of Diabetes Research
https://www.readbyqxmd.com/read/29137278/comprehensive-microrna-sequencing-of-exosomes-derived-from-head-and-neck-carcinoma-cells-in-vitro-reveals-common-secretion-profiles-and-potential-utility-as-salivary-biomarkers
#4
Scott Langevin, Damaris Kuhnell, Tess Parry, Jacek Biesiada, Shouxiong Huang, Trisha Wise-Draper, Keith Casper, Xiang Zhang, Mario Medvedovic, Susan Kasper
Exosomes are nano-scale, membrane encapsulated vesicles that are released by cells into the extracellular space and function as intercellular signaling vectors through horizontal transfer of biologic molecules, including microRNA (miRNA). There is evidence that cancer-derived exosomes enable the tumor to manipulate its microenvironment, thus contributing to the capacity of the tumor for immune evasion, growth, invasion, and metastatic spread. The objective of this study was to characterize differential secretion of exosomal miRNA by head and neck squamous cell carcinoma (HNSCC) and identify a set of candidate biomarkers that could be detected in non-invasive saliva samples...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134827/serum-plasma-and-saliva-biomarkers-for-head-and-neck-cancer
#5
Lidia Maria Rebolho Batista Arantes, Ana Carolina de Carvalho, Matias Eliseo Melendez, André Lopes Carvalho
Head and neck squamous cell carcinoma (HNSCC) encompasses tumors arising from several locations (oral and nasal cavities, paranasal sinuses, salivary glands, pharynx, and larynx) and currently stands as the sixth most common cancer worldwide. The most important risk factors identified so far are tobacco and alcohol consumption, and, for a subgroup of HNSCCs, infection with high-risk types of human papillomavirus (HPV). Despite several improvements in the treatment of these tumors in the last decades, overall survival rates have only improved marginally, mainly due to the advanced clinical stage at diagnosis and the high rates of treatment failure associated with this late diagnosis...
November 14, 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/29130773/alteration-of-salivary-glycopatterns-in-oral-lichen-planus
#6
Liang Fang, Qing Liu, Pengfei He, Xinwen Wang, Ying Wang, Minghui Wei, Lihua Chen
BACKGROUND: Oral lichen planus (OLP) is one of the most common oral mucosal lesions affecting 0.5% to 2% of the adult population. It is difficult to distinguish between OLP and other oral mucosal diseases. Structural changes in the glycans of saliva proteins might be reliable indicators of OLP. However, little is known about the alteration of salivary glycopatterns during OLP. OBJECTIVE: We aimed to investigate the alterations of salivary protein glycosylation related to OLP...
November 13, 2017: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29129647/salivary-biomarker-combination-prediction-model-for-the-diagnosis-of-periodontitis-in-a-taiwanese-population
#7
Yun-Chun Wu, Lee Ning, Yu-Kang Tu, Chen-Pang Huang, Nien-Tsu Huang, Yih-Fan Chen, Po-Chun Chang
BACKGROUND/PURPOSE: This study aimed at screening the diagnostic potential of salivary biomarkers and pairing them to establish a prediction model with higher accuracy in diagnosing periodontitis in the Taiwanese population. METHODS: Fifty-seven participants were divided into a non-periodontitis group and a periodontitis group. Salivary biomarkers CRP, IL-6, IL-8, IL-1β, IL-1ra, lactoferrin, MMP-8, MMP-9, PDGF-BB, TNF-α, and VEGF, were analyzed. The potential and reliability of the biomarkers for diagnosing periodontitis were analyzed dichotomously...
November 9, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29127717/salivary-uric-acid-and-c-reactive-protein-associations-with-hypertensionin-midwestern-latino-preadolescents-and-their-parents
#8
Blake L Jones, Salma Elwazeer, Zoe E Taylor
Latino families face increased risk for hypertension. Serum-based uric acid and C-reactive protein have been linked to hypertension. However, a paucity of salivary biomarker data exists in this area for Latino families. Using salivary biomarkers enables less invasive options for biomedical and biosocial research, which is especially important among vulnerable populations facing increased health disparities. This study examined the associations between salivary uric (sUA) acid, salivary C-reactive protein (sCRP), and hypertension among 151 participants (57 children, 57 mothers, 37 fathers) from 57 Midwestern Latino families...
November 11, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/29125139/salivary-proteins-and-microbiota-as-biomarkers-for-early-childhood-caries-risk-assessment
#9
REVIEW
Abdullah S Hemadi, Ruijie Huang, Yuan Zhou, Jing Zou
Early childhood caries (ECC) is a term used to describe dental caries in children aged 6 years or younger. Oral streptococci, such as Streptococcus mutans and Streptococcus sorbrinus, are considered to be the main etiological agents of tooth decay in children. Other bacteria, such as Prevotella spp. and Lactobacillus spp., and fungus, that is, Candida albicans, are related to the development and progression of ECC. Biomolecules in saliva, mainly proteins, affect the survival of oral microorganisms by multiple innate defensive mechanisms, thus modulating the oral microflora...
November 10, 2017: International Journal of Oral Science
https://www.readbyqxmd.com/read/29109737/associations-of-salivary-bpifa1-protein-in-chronic-periodontitis-patients-with-type-2-diabetes-mellitus
#10
Yue Guo, Lin-Na Guo, Jun-Fei Zhu, Chen-Yi Tang, Yun-Zhi Feng, Hou-De Zhou
Aims: To explore the differences in salivary BPI fold containing family A, member 1 (BPIFA1) concentration among type 2 diabetes mellitus (T2DM) subjects with various severities of chronic periodontitis and to determine whether BPIFA1 in saliva can be used as a potential biomarker of T2DM. Methods: Unstimulated saliva samples were collected from 44 subjects with T2DM and 44 without T2DM (NDM). Additionally, demographic data and general health parameters, including fasting blood glucose (FBG) and body mass index (BMI), were collected...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/29108921/micrornas-expression-pattern-related-to-mast-cell-activation-and-angiogenesis-in-paraffin-embedded-salivary-gland-tumors
#11
Poliana Ramos Braga Santos, Claúdia Malheiros Coutinho-Camillo, Fernando Augusto Soares, Valéria Souza Freitas, Deise Souza Vilas-Bôas, Flávia Caló Aquino Xavier, Clarissa Araújo Gurgel Rocha, Iguaracyra Barreto de Araújo, Jean Nunes Dos Santos
The aim of this study was evaluate the expression profile of microRNAs related to mast cells activation and angiogenesis in salivary glands tumors. METHOD: We have analyzed the expression of miR-9, miR-16, miR-17, miR-132, miR-195 and miR-221 by real-time RT-PCR, in 11 adenoid cystic carcinomas, 9 mucoepidermoid carcinomas and 11 pleomorphic adenomas. Immunohistochemical investigation was performed to detect mast cells tryptase and CD-34 for microvessels biomarkers. miR-16, miR-17, miR-132, miR-195 and miR-221 showed a decreased expression, whereas miR-9 showed an increased expression in most cases compared to normal tissues...
October 18, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/29106854/salivary-cotinine-levels-in-children-with-otolaryngological-disorders
#12
Christine M Clark, Jillian N Printz, Lauren E Stahl, Brett E Phillips, Michele M Carr
OBJECTIVE: To determine if salivary cotinine, a biomarker for tobacco smoke exposure, is elevated more often or to a higher degree in children meeting criteria for tonsillectomy or tympanostomy tube insertion. METHODS: Saliva samples were obtained from 3 groups of children for salivary cotinine measurement. Group 1 served as healthy controls. Group 2 consisted of subjects meeting tympanostomy tube criteria. Group 3 consisted of patients meeting tonsillectomy criteria...
November 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29103042/alzheimer-s-disease-can-be-spared-by-nonsteroidal-anti-inflammatory-drugs
#13
Patrick L McGeer, Jian Ping Guo, Moonhee Lee, Krista Kennedy, Edith G McGeer
Alzheimer's disease (AD) is characterized by deposits of amyloid-β protein (Aβ) in brain which become foci of inflammation. Neurons are destroyed by this inflammatory process, leading to the cognitive deficits which define AD clinical onset. Epidemiological studies indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) can ameliorate this destructive process if they are started well before clinical signs develop. Biomarker studies indicate that the disease process starts at least a decade before cognitive deficits appear...
October 30, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29102505/validity-of-self-reported-intensity-of-exposure-to-second-hand-smoke-at-home-against-environmental-and-personal-markers
#14
José M Martínez-Sánchez, Adrián González-Marrón, Juan Carlos Martín-Sánchez, Xisca Sureda, Marcela Fu, Raúl Pérez-Ortuño, Cristina Lidón-Moyano, Iñaki Galán, José Antonio Pascual, Esteve Fernández
The objective of this study was to assess the validity of two questions about the perception of intensity of exposure to secondhand smoke (SHS) at home using as a reference environmental markers (airborne nicotine and benzene) and biomarkers of exposure (cotinine in saliva and urine). This was a cross-sectional study in a convenience sample of 49 non-smoking volunteers. We found a high correlation between self-reported SHS exposure and airborne nicotine (rsp=0.806, p<0.05), salivary cotinine (rsp=0.752, p<0...
November 1, 2017: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29081351/integrating-biological-treatment-mechanisms-into-randomized-clinical-trials-design-of-progress-prolonged-exposure-and-sertraline-trial
#15
Sheila A M Rauch, Naomi M Simon, H Myra Kim, Ron Acierno, Anthony P King, Sonya B Norman, Margaret R Venners, Katherine Porter, K Luan Phan, Peter W Tuerk, Carolyn Allard, Israel Liberzon, Barbara O Rothbaum, Brian Martis, Murray B Stein, Charles W Hoge
Increased emphasis on mechanisms of treatment effectiveness, biomarker predictors, and objective indicators of treatment response has sparked interest in integrated, translational treatment outcomes trials. The PROlonGed ExpoSure and Sertraline Trial (PROGrESS) is one such randomized controlled trial (RCT) focused on a key question in clinical management of posttraumatic stress disorder (PTSD) - the comparative and combined effectiveness of medication and psychotherapy. PROGrESS employs a state of the art trial design to examine psychotherapy and medication effects across three conditions: 1) Prolonged Exposure (PE) plus pill placebo, 2) Sertraline (SERT) plus Enhanced Medication Management (EMM), and 3) Combined treatment (PE/SERT)...
October 29, 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29080448/assessment-of-salivary-cotinine-concentration-among-general-non-smokers-population-before-and-after-spanish-smoking-legislations
#16
Cristina Lidón-Moyano, Marcela Fu, Raúl Perez-Ortuño, Montse Ballbè, Marc Sampedro-Vida, Juan Carlos Martín-Sánchez, José A Pascual, Esteve Fernández, Jose M Martínez-Sánchez
BACKGROUND: In Spain, two smoke-free laws have been passed (Law 28/2005 and Law 42/2010).This study evaluates the association between Spanish smoking legislations and the second-hand smoke (SHS) exposure in an adult non-smoking population cohort in Barcelona (Spain). METHODS: This is a longitudinal study, before and after the implementation of two national smoking bans, in a representative sample of adults (≥16years old) from Barcelona (Spain) surveyed in 2004-2005 and followed up in 2013-2014 (n=736)...
October 25, 2017: Cancer Epidemiology
https://www.readbyqxmd.com/read/29080017/safety-pharmacokinetics-metabolism-and-radiation-dosimetry-of-18-f-tetrafluoroborate-18-f-tfb-in-healthy-human-subjects
#17
Huailei Jiang, Nicholas R Schmit, Alex R Koenen, Aditya Bansal, Mukesh K Pandey, Robert B Glynn, Bradley J Kemp, Kera L Delaney, Angela Dispenzieri, Jamie N Bakkum-Gamez, Kah-Whye Peng, Stephen J Russell, Tina M Gunderson, Val J Lowe, Timothy R DeGrado
BACKGROUND: (18)F-Tetrafluoroborate ((18)F-TFB) is a promising iodide analog for PET imaging of thyroid cancer and sodium/iodide symporter (NIS) reporter activity in viral therapy applications. The aim of this study was to evaluate the safety, pharmacokinetics, biodistribution, and radiation dosimetry of high-specific activity (18)F-TFB in healthy human subjects. METHODS: (18)F-TFB was synthesized with specific activity of 3.2 ± 1.3 GBq/μmol (at the end of synthesis)...
October 27, 2017: EJNMMI Research
https://www.readbyqxmd.com/read/29076877/the-role-of-molecular-testing-in-the-differential-diagnosis-of-salivary-gland-carcinomas
#18
Alena Skálová, Göran Stenman, Roderick H W Simpson, Henrik Hellquist, David Slouka, Tomas Svoboda, Justin A Bishop, Jennifer L Hunt, Ken-Ichi Nibu, Alessandra Rinaldo, Vincent Vander Poorten, Kenneth O Devaney, Petr Steiner, Alfio Ferlito
Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Mammary analog secretory carcinoma is a recently described entity characterized by a t(12;15)(p13;q25) translocation resulting in an ETV6-NTRK3 fusion...
October 26, 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/29069786/the-overexpression-of-salivary-cytokeratins-as-potential-diagnostic-biomarkers-in-head-and-neck-squamous-cell-carcinomas
#19
Kai Dun Tang, Liz Kenny, Chris Perry, Ian Frazer, Chamindie Punyadeera
BACKGROUND: Cytokeratin (CK) intermediate filaments are demonstrated to have enormous potential in regulating cellular motility and cancer progression. There are more than 20 divergent CKs that have been identified, of which CK 8, 17, 18 and 19 are reported to be elevated in the tumour biopsies of head and neck cancer squamous cell carcinoma (HNSCC) patients. However, CK expression profiles in the saliva of HNSCC patients have not been investigated. We aim to investigate the mRNA expression profiles of CKs in saliva collected from healthy controls, HPV-negative and -positive HNSCC patients...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29065770/salivary-cortisol-reactivity-in-preschoolers-is-associated-with-hair-cortisol-and-behavioral-problems
#20
Katie Kao, Stacey N Doan, Ashley M St John, Jerrold S Meyer, Amanda R Tarullo
The interplay between children's cortisol reactivity to challenge and cumulative cortisol exposure is not well understood. Examining the role of cortisol reactivity in early childhood may elucidate biological mechanisms that contribute to children's chronic physiological stress and behavioral dysregulation. In a sample of 65 preschool-aged children, we examined the relation between children's salivary cortisol reactivity to challenging tasks and their hair cortisol concentration (HCC). While both are biomarkers of the hypothalamic-pituitary-adrenal (HPA) axis, salivary cortisol reactivity reflects an acute cortisol response to a stressor and HCC reflects cumulative cortisol exposure...
October 24, 2017: Stress: the International Journal on the Biology of Stress
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