keyword
MENU ▼
Read by QxMD icon Read
search

Salivary biomarkers

keyword
https://www.readbyqxmd.com/read/28068899/maternal-bmi-as-a-predictor-of-methylation-of-obesity-related-genes-in-saliva-samples-from-preschool-age-hispanic-children-at-risk-for-obesity
#1
Kathryn Tully Oelsner, Yan Guo, Sophie Bao-Chieu To, Amy L Non, Shari L Barkin
BACKGROUND: The study of epigenetic processes and mechanisms present a dynamic approach to assess complex individual variation in obesity susceptibility. However, few studies have examined epigenetic patterns in preschool-age children at-risk for obesity despite the relevance of this developmental stage to trajectories of weight gain. We hypothesized that salivary DNA methylation patterns of key obesogenic genes in Hispanic children would 1) correlate with maternal BMI and 2) allow for identification of pathways associated with children at-risk for obesity...
January 9, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28050904/paper-based-analytical-biosensor-chip-designed-from-graphene-nanoplatelet-amphiphilic-di-block-co-polymer-composite-for-cortisol-detection-in-human-saliva
#2
Muhammad Khan, Santosh K Misra, Zhen Wang, Enrique A Daza, Aaron Schwartz-Duval, Joseph Kus, Debanjan Pan, Dipanjan Pan
Cortisol has been identified as a biomarker in saliva to monitor psychological stress. In this work, we report label-free paper-based electrical biosensor chip to quantify salivary cortisol at a point-of-care (POC) level. A high specificity of the sensor chip to detect cortisol with detection limit of 3 pg/mL was achieved by conjugating anti-cortisol antibody (anti-CAB) on top of gold (Au) microelectrodes using 3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester (DTSP) - as self-assembled monolayer (SAM) agent...
January 4, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28050886/evaluation-of-cortisol-and-telomere-length-measurements-in-ethnically-diverse-women-with-breast-cancer-using-culturally-sensitive-methods
#3
Julio Ramirez, May Elmofty, Esperanza Castillo, Mindy DeRouen, Salma Shariff-Marco, Laura Allen, Scarlett Lin Gomez, Anna María Nápoles, Leticia Márquez-Magaña
The under-representation of ethnic minority participants, who are more likely to be socially disadvantaged in biomedical research, limits generalizability of results and reductions in health disparities. To facilitate investigations of how social disadvantage "gets under the skin," this pilot study evaluated low-intensity methods for collecting hair and saliva samples from multiethnic breast cancer survivors (N = 70) and analysis of biomarkers of chronic stress (cortisol levels) and biological age (telomere length)...
January 3, 2017: Journal of Community Genetics
https://www.readbyqxmd.com/read/28036132/diagnostic-accuracy-of-salivary-and-serum-free-light-chain-assays-in-primary-sj%C3%A3-gren-s-syndrome-a-pilot-study
#4
Pulukool Sandhya, Pamela Christudoss, Jayakanthan Kabeerdoss, Santosh K Mandal, Ramya Aithala, Gowri Mahasampath, Victoria Job, Debashish Danda
OBJECTIVE: To estimate levels of salivary and serum free light chains (FLCs) and explore its utility as a biomarker in primary Sjögren's syndrome (pSS). METHODS: Patients with pSS classified by American European Consensus group 2002 or American College of Rheumatology 2012 criteria between January 2015 and August 2015 were included. Healthy staff and non-first degree relatives of patients constituted controls. Serum and salivary FLCs were measured by immunoturbidometry using FREELITE(™) Human Kappa(κ) and Lambda(λ) Free Kit (Binding site, Birmingham, UK), on a Roche Modular P800...
December 30, 2016: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28028643/parkinson-s-a-syndrome-rather-than-a-disease
#5
REVIEW
Nataliya Titova, C Padmakumar, Simon J G Lewis, K Ray Chaudhuri
Emerging concepts suggest that a multitude of pathology ranging from misfolding of alpha-synuclein to neuroinflammation, mitochondrial dysfunction, and neurotransmitter driven alteration of brain neuronal networks lead to a syndrome that is commonly known as Parkinson's disease. The complex underlying pathology which may involve degeneration of non-dopaminergic pathways leads to the expression of a range of non-motor symptoms from the prodromal stage of Parkinson's to the palliative stage. Non-motor clinical subtypes, cognitive and non-cognitive, have now been proposed paving the way for possible subtype specific and non-motor treatments, a key unmet need currently...
December 27, 2016: Journal of Neural Transmission
https://www.readbyqxmd.com/read/28013436/opiorphin-in-burning-mouth-syndrome-patients-a-case-control-study
#6
Ivan Salarić, Maja Sabalić, Ivan Alajbeg
OBJECTIVES: Opiorphin is a pentapeptide isolated from human saliva that suppresses pain from chemically induced inflammation and acute physical pain. Burning mouth syndrome (BMS) is a chronic condition of a burning sensation in the mouth, where no underlying dental or medical cause can be identified. We aimed to measure the level of opiorphin in whole unstimulated (UWS) and stimulated (SWS) saliva of patients with BMS. MATERIALS AND METHODS: Originally developed and validated LC-MS/MS method was used for opiorphin quantification...
December 24, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/28006716/biomolecular-aspects-of-depression-a-retrospective-analysis
#7
Brandon N Peacock, David J Scheiderer, Gottfried H Kellermann
OBJECTIVE: The effects of psychological stress, oxidative stress, and chronic low grade inflammation on the neuro-immune connection have been implicated in the pathogenesis of depression. Thus, in the recent past, there has been a growing effort in determining the mechanism of this pathogenesis. While attempting to map out, this mechanism researchers and clinicians have searched for clinically relevant biomarkers for use in the diagnosis and for the assessment of those suffering from depression...
November 10, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28005264/mucin-4-and-matrix-metalloproteinase-7-as-novel-salivary-biomarkers-for-periodontitis
#8
Anna Lundmark, Gunnar Johannsen, Kaja Eriksson, Anna Kats, Leif Jansson, Taina Tervahartiala, Nilminie Rathnayake, Sigvard Åkerman, Björn Klinge, Timo Sorsa, Tülay Yucel-Lindberg
AIM: Periodontitis is a chronic inflammatory disease, characterized by irreversible destruction of tooth-supporting tissue including alveolar bone. We recently reported mucin 4 (MUC4) and matrix metalloproteinase 7 (MMP7) as highly associated with periodontitis in gingival tissue biopsies. The aim of this study was to further investigate the levels of MUC4 and MMP7 in saliva and gingival crevicular fluid (GCF) samples of patients with periodontitis. MATERIALS AND METHODS: Saliva and GCF samples were collected from periodontitis patients and healthy controls...
December 22, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27999326/oral-biofluid-biomarker-research-current-status-and-emerging-frontiers
#9
REVIEW
Austin Wang, Chris P Wang, Michael Tu, David T W Wong
Salivary diagnostics is a rapidly advancing field that offers clinicians and patients the potential of rapid, noninvasive diagnostics with excellent accuracy. In order for the complete realization of the potential of saliva, however, extensive profiling of constituents must be conducted and diagnostic biomarkers must be thoroughly validated. This article briefly overviews the process of conducting a study of salivary biomarkers in a patient cohort and highlights the studies that have been conducted on different classes of molecules in the saliva...
December 17, 2016: Diagnostics
https://www.readbyqxmd.com/read/27998757/intraindividual-stability-of-cortisol-and-cortisone-and-the-ratio-of-cortisol-to-cortisone-in-saliva-urine-and-hair
#10
Quan Zhang, Zheng Chen, Shenghuo Chen, Youyun Xu, Huihua Deng
BACKGROUND: Cortisol, cortisone and the ratio of cortisol to cortisone in saliva, urine and hair are acute, short-term and long-term biomarkers to reliably assess the activity of hypothalamic-pituitary-adrenal (HPA) axis and 11β-hydroxysteroid dehydrogenase (11β-HSD). One key issue is whether these biomarkers have intraindividual relative stability. Salivary, urinary and hair cortisol was proven to show considerable long-term intraindividual relative stability. However, currently unknown is whether cortisone and the ratio in saliva, urine and hair show intraindividual relative stability...
December 18, 2016: Steroids
https://www.readbyqxmd.com/read/27997348/relationship-between-plasma-and-salivary-melatonin-and-cortisol-investigated-by-lc-ms-ms
#11
Martijn van Faassen, Rainer Bischoff, Ido P Kema
BACKGROUND: Disturbance of the circadian rhythm has been associated with disease states, such as metabolic disorders, depression and cancer. Quantification of the circadian markers such as melatonin and cortisol critically depend on reliable and reproducible analytical methods. Previously, melatonin and cortisol were primarily analyzed separately, mainly using immunoassays. METHODS: Here we describe the validation and application of a high-throughput liquid chromatography in combination with mass spectrometry (LC-MS/MS) method for the combined analysis of melatonin and cortisol in plasma and saliva...
December 20, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27994421/evaluation-of-melatonin-levels-in-saliva-in-gingivitis-and-periodontitis-cases-a-pilot-study
#12
Karuna Lodhi, Charanjit Singh Saimbi, Mohammad Akhlaq Khan, Chandishwar Nath, Rakesh Shukla
OBJECTIVE: To evaluate the melatonin levels in saliva in gingivitis and periodontitis cases. BACKGROUND: Melatonin has strong antioxidant, free radical scavenging, and immunomodulating properties, acts on osteoblasts directly to stimulate cell proliferation and synthesis of Type I collagen, and promotes bone formation. MATERIALS AND METHODS: A total of thirty participants were selected and divided into three groups (control group, gingivitis group, and periodontitis group)...
October 2016: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/27988433/igg4-related-disease-evidence-from-six-recent-cohorts
#13
REVIEW
Fernando Martínez-Valle, Andreu Fernández-Codina, Iago Pinal-Fernández, Olimpia Orozco-Gálvez, Miquel Vilardell-Tarrés
IgG4-related disease (IgG4-RD) is a rare autoimmune fibrosing disorder. In this review we aim to describe and compare the characteristics of the six largest IgG4-RD cohorts, since the new 2012 consensus diagnostic criteria were released. These observational studies were published between 2012 and 2015. Patients were included using the comprehensive diagnostic criteria or the 2012 consensus criteria. Results were reviewed and summarized. Most patients were middle aged men. Fibro-inflammatory masses developed in virtually all organs except the brain, with an unexplained preference for salivary glands, lymph nodes and pancreas...
December 15, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27987039/salivary-oxidative-stress-biomarkers-in-chronic-periodontitis-and-acute-coronary-syndrome
#14
Thuy T Nguyen, Lan Q Ngo, Ananya Promsudthi, Rudee Surarit
OBJECTIVES: The study aimed at assessing oxidative stress (OS) biomarker levels in the saliva of patients with chronic periodontitis (CP) and acute coronary syndrome (ACS) and establishing their correlation to periodontal parameters and markers for cardiovascular events. MATERIALS AND METHODS: The present study enrolled 24 patients with ACS and CP (the ACSCP group), 24 patients with ACS only (the ACS group), 24 patients with CP only (the CP group), and 24 healthy controls...
December 16, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27978919/-current-advance-in-saliva-derived-exosome-study
#15
Y Zhao, L Y Yin, R R Bi, P Ma, S B Li
There is growing interest in the whole saliva as a diagnostic fluid because of the relatively simple and non-invasive collection. Research on salivary proteomic and genomic has greatly facilitated the diagnosis and therapy of oral diseases, also revealed the molecular mechanism of the diseases. Saliva-derived exosome as a new source, with various molecular constituents of their cells of origin, including proteins, mRNA and miRNA might serve as potential biomarker. This article reviews the biological properties of saliva exosome, its separation and other aspects associated with disease...
December 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27965259/standardisation-of-labial-salivary-gland-histopathology-in-clinical-trials-in-primary-sj%C3%A3-gren-s-syndrome
#16
Benjamin A Fisher, Roland Jonsson, Troy Daniels, Michele Bombardieri, Rachel M Brown, Peter Morgan, Stefano Bombardieri, Wan-Fai Ng, Athanasios G Tzioufas, Claudio Vitali, Pepe Shirlaw, Erlin Haacke, Sebastian Costa, Hendrika Bootsma, Valerie Devauchelle-Pensec, Timothy R Radstake, Xavier Mariette, Andrea Richards, Rebecca Stack, Simon J Bowman, Francesca Barone
Labial salivary gland (LSG) biopsy is used in the classification of primary Sjögren's syndrome (PSS) and in patient stratification in clinical trials. It may also function as a biomarker. The acquisition of tissue and histological interpretation is variable and needs to be standardised for use in clinical trials. A modified European League Against Rheumatism consensus guideline development strategy was used. The steering committee of the ad hoc working group identified key outstanding points of variability in LSG acquisition and analysis...
December 13, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27943336/verification-of-protein-biomarkers-for-the-identification-of-biological-stains-by-quadrupole-time-of-flight-mass-spectrometry
#17
Kevin M Legg, Roger Powell, Nichole Reisdorph, Rick Reisdorph, Phillip B Danielson
Advances in proteomics technology over the past decade offer forensic serologists a greatly improved opportunity to accurately characterize the tissue source from which a DNA has been developed. Such information can provide critical context to evidence and can help to prioritize downstream DNA analysis. Previous proteome studies compiled panels of "candidate biomarkers" specific to each of six body fluids (i.e. peripheral blood, menstrual fluid, vaginal fluid, seminal fluid, urine and saliva). Here, a multiplex Quadrupole Time-of-flight assay has been developed in order to verify the tissue/body fluid specificity the 23 protein biomarkers that comprise these panels and the consistency with which they can be detected across a samples population of fifty humans...
December 12, 2016: Electrophoresis
https://www.readbyqxmd.com/read/27943101/salivary-biomarkers-in-cancer-detection
#18
REVIEW
Xiaoqian Wang, Karolina Elżbieta Kaczor-Urbanowicz, David T W Wong
Cancer is the second most common cause of death in the USA. Its symptoms are often not specific and absent, until the tumors have already metastasized. Therefore, there is an urgent demand for developing rapid, highly accurate and noninvasive tools for cancer screening, early detection, diagnostics, staging and prognostics. Saliva as a multi-constituent oral fluid comprises secretions from the major and minor salivary glands, extensively supplied by blood. Molecules such as DNAs, RNAs, proteins, metabolites, and microbiota, present in blood, could be also found in saliva...
January 2017: Medical Oncology
https://www.readbyqxmd.com/read/27932615/anopheles-salivary-biomarker-to-assess-malaria-transmission-risk-along-the-thailand-myanmar-border
#19
Phubeth Ya-Umphan, Dominique Cerqueira, Daniel M Parker, Gilles Cottrell, Anne Poinsignon, Franck Remoue, Cecile Brengues, Theeraphap Chareonviriyaphap, Francois Nosten, Vincent Corbel
BACKGROUND: The modalities of malaria transmission along the Thailand-Myanmar border are poorly understood. Here we address the relevance of using a specific Anopheles salivary biomarker to measure the risk of human exposure to anopheles bites. METHODS: Serologic surveys were conducted from May 2013 to December 2014 in 4 sentinel villages. Dried blood spots (n>9,400) were collected in filter papers among all inhabitants at baseline and then every three months up to 18 months...
December 8, 2016: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27928087/operational-assessment-of-long-lasting-insecticidal-nets-by-using-an-anopheles-salivary-biomarker-of-human-vector-contact
#20
Mahoutin H Noukpo, Georgia B Damien, Emmanuel Elanga-N'Dille, André B Sagna, Papa M Drame, Evelyne Chaffa, Olayidé Boussari, Vincent Corbel, Martin Akogbéto, Franck Remoue
The widespread implementation of long-lasting insecticidal nets (LLINs) is a major intervention method for malaria control. Although the LLINs coverage increases, information available on the physical integrity (PI) of implemented LLINs is incomplete. This study aimed to validate human IgG antibody (Ab) response to Anopheles gSG6-P1 salivary peptide antigen, previously demonstrated as a pertinent biomarker of human exposure to Anopheles bites, for evaluating the PI of LLINs in field conditions. We analyzed data from 262 randomly selected children (< 5 years of age) in health districts of Benin...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
keyword
keyword
28148
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"