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Motion sickness

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https://www.readbyqxmd.com/read/28093476/muscarinic-acetylcholine-receptors-and-m-currents-underlie-efferent-mediated-slow-excitation-in-calyx-bearing-vestibular-afferents
#1
J Chris Holt, Paivi M Jordan, Anna Lysakowski, Amit Shah, Kathy Barsz, Donatella Contini
: Stimulation of vestibular efferent neurons excites calyx and dimorphic (CD) afferents. This excitation consists of fast and slow components that differ over 100-fold in activation kinetics and response duration. In turtle, efferent-mediated fast excitation arises in CD afferents when the predominant efferent neurotransmitter acetylcholine (ACh) activates calyceal nicotinic ACh receptors (nAChRs); however, it is unclear whether the accompanying efferent-mediated slow excitation is also attributed to cholinergic mechanisms...
January 16, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28061915/prevalence-predictors-and-prevention-of-motion-sickness-in-zero-g-parabolic-flights
#2
John F Golding, Aurore C Paillard, Hervé Normand, Stéphane Besnard, Pierre Denise
INTRODUCTION: Zero-G parabolic flight reproduces the weightlessness of space for short periods. However, motion sickness may affect some fliers. The aim was to assess the extent of this problem and to find possible predictors and modifying factors. METHODS: Airbus zero-G flights consist of 31 parabolas performed in blocks. Each parabola consisted of 20 s of 0 g sandwiched by 20 s of hypergravity of 1.5-1.8 g. The survey covered N = 246 person-flights (193 men, 53 women), ages (M ± SD) 36...
January 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/28010995/profiling-subjective-symptoms-and-autonomic-changes-associated-with-cybersickness
#3
Alireza Mazloumi Gavgani, Keith V Nesbitt, Karen L Blackmore, Eugene Nalivaiko
Our aim was to expand knowledge of cybersickness - a subtype of motion sickness provoked by immersion into a moving computer-generated virtual reality. Fourteen healthy subjects experienced a 15-min rollercoaster ride presented via a head-mounted display (Oculus Rift), for 3 consecutive days. Heart rate, respiration, finger and forehead skin conductance were measured during the experiment; this was complemented by a subjective nausea rating during the ride and by Motion Sickness Assessment Questionnaire before, immediately after and then 1, 2 and 3h post-ride...
December 18, 2016: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27986366/end-tidal-co2-relates-to-seasickness-susceptibility-a-study-in-antarctic-voyages
#4
Tatsuhisa Hasegawa, Hirofumi Oe, Masakatsu Taki, Hirofumi Sakaguchi, Shigeru Hirano, Yoshiro Wada
OBJECTIVE: To investigate the relationship between end-tidal CO2 (EtCO2) and seasickness (motion sickness at sea) during an Antarctic voyage. METHODS: In this study, we measured EtCO2 and severity of seasickness using the subjective symptoms of motion sickness (SSMS). We sampled EtCO2 and SSMS every 3-4h for 3 days from the date of sail in 16 healthy subjects. This experiment was performed on an icebreaker (standard displacement: 12,650t). RESULTS: Since 2 subjects dropped out because of severe motion sickness, available data were collected from 14 subjects...
December 13, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27918236/meniere-s-migraine-and-motion-sickness
#5
John F Golding, Mitesh Patel
CONCLUSION: Elevated Motion Sickness Susceptibility (MSS) in Meniere?s disease (MD) is likely to be a consequence of the onset of MD and not migraine per se. OBJECTIVES: Pathologies of the vestibular system influence MSS. Bilateral vestibular deficits lower MSS, vestibular neuritis or benign paroxysmal positional vertigo have little overall effect, whereas vestibular migraine elevates MSS. However, less is known about MSS in MD, a condition in which many patients experience vestibular loss and migraine symptoms...
December 5, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27915367/the-virtual-reality-head-mounted-display-oculus-rift-induces-motion-sickness-and-is-sexist-in-its-effects
#6
Justin Munafo, Meg Diedrick, Thomas A Stoffregen
Anecdotal reports suggest that motion sickness may occur among users of contemporary, consumer-oriented head-mounted display systems and that women may be at greater risk. We evaluated the nauseogenic properties of one such system, the Oculus Rift. The head-mounted unit included motion sensors that were sensitive to users' head movements, such that head movements could be used as control inputs to the device. In two experiments, seated participants played one of two virtual reality games for up to 15 min. In Experiment 1, 22% of participants reported motion sickness, and the difference in incidence between men and women was not significant...
December 3, 2016: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
https://www.readbyqxmd.com/read/27894470/effectiveness-of-a-placebo-intervention-on-visually-induced-nausea-in-women-a-randomized-controlled-pilot-study
#7
Veronika Müller, Kirsten Remus, Verena Hoffmann, Matthias H Tschöp, Karin Meissner
OBJECTIVE: Improvement of nausea by placebo interventions has recently been demonstrated in clinical trials and experimental settings. However, many questions regarding placebo effects on nausea remain unanswered. For example, nausea reduction in women could only be achieved when the placebo intervention was "enhanced" by conditioning, while men responded primarily to verbally suggested improvement. It is unclear whether these findings are generalizable or were due to situational variables...
December 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27814310/asymmetries-and-three-dimensional-features-of-vestibular-cross-coupled-stimuli-illuminated-through-modeling
#8
Jan E Holly, M Arjumand Masood, Chiran S Bhandari
Head movements during sustained rotation can cause angular cross-coupling which leads to tumbling illusions. Even though angular vectors predict equal magnitude illusions for head movements in opposite directions, the magnitudes of the illusions are often surprisingly asymmetric, such as during leftward versus rightward yaw while horizontal in a centrifuge. This paper presents a comprehensive investigation of the angular-linear stimulus combinations from eight different published papers in which asymmetries were found...
November 3, 2016: Journal of Vestibular Research: Equilibrium & Orientation
https://www.readbyqxmd.com/read/27803457/an-analysis-of-behavioral-and-genetic-risk-factors-for-chemotherapy-induced-nausea-and-vomiting-in-japanese-subjects
#9
Naoki Mukoyama, Akira Yoshimi, Aya Goto, Haruka Kotani, Kazuhiro Ishikawa, Noriko Miyazaki, Masayuki Miyazaki, Kiyofumi Yamada, Fumitaka Kikkawa, Yoshinori Hasegawa, Norio Ozaki, Yukihiro Noda
There are individual differences in the frequency of chemotherapy-induced nausea and vomiting (CINV) in cancer patients. We investigated the individual variability in susceptibility to CINV with focus on both behavioral factors and genetic factors in Japanese cancer patients. We performed a prospective study to investigate the association between patient attributes (backgrounds and habits as well as gene polymorphisms) and anorexia, nausea, or vomiting in 55 Japanese cancer patients undergoing chemotherapy at Nagoya University Hospital...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27779955/psychometric-properties-of-the-greek-version-of-the-gianaros-motion-sickness-assessment-questionnaire
#10
COMMENT
Panagiotis Kousoulis, Athanasios Pantes, Georgios Alevetsovitis, Ourania Fydanaki
INTRODUCTION: The Motion Sickness Assessment Questionnaire (MSAQ) was developed in order to assess the multiple dimensions of the motion sickness syndrome (gastrointestinal, central nervous system, peripheral, and sopite-related symptoms). The aim of this study was to evaluate the psychometric properties of the Greek version of the MSAQ. METHODS: The MSAQ was translated into Greek and then translated back into English. Minor differences between the two texts were corrected...
2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27770585/comparison-of-a-virtual-older-driver-assessment-with-an-on-road-driving-test
#11
Ranmalee Eramudugolla, Jasmine Price, Sidhant Chopra, Xiaolan Li, Kaarin J Anstey
OBJECTIVES: To design a low-cost simulator-based driving assessment for older adults and to compare its validity with that of an on-road driving assessment and other measures of older driver risk. DESIGN: Cross-sectional observational study. SETTING: Canberra, Australia. PARTICIPANTS: Older adult drivers (N = 47; aged 65-88, mean age 75.2). MEASUREMENTS: Error rate on a simulated drive with environment and scoring procedure matched to those of an on-road test...
December 2016: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/27767902/maternal-administration-of-meclozine-for-the-treatment-of-foramen-magnum-stenosis-in-transgenic-mice-with-achondroplasia
#12
Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
OBJECTIVE Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Foramen magnum stenosis (FMS) is one of the serious neurological complications in ACH. Through comprehensive drug screening, the authors identified that meclozine, an over-the-counter drug for motion sickness, inhibited activation of FGFR3 signaling. Oral administration of meclozine to the growing ACH mice promoted longitudinal bone growth, but it did not prevent FMS...
January 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/27737380/integrative-review-of-factors-related-to-the-nursing-diagnosis-nausea-during-antineoplastic-chemotherapy
#13
Aline Maria Bonini Moysés, Lais Corsino Durant, Ana Maria de Almeida, Thais de Oliveira Gozzo
Objective: to identify factors related to the nursing diagnosis nausea among cancer patients undergoing chemotherapy. Method: integrative review conducted in four electronic databases (PUBMED, EMBASE, CINAHL and LILACS) using the key words: neoplasia, antineoplastic agents and nausea. Results: only 30 out of 1,258 papers identified met the inclusion criteria. The most frequent related factors were: being younger than 50 years old, motion sickness, being a woman, emetogenic potential of the chemotherapy, anxiety, conditioned stimulus, and expecting nausea after treatment...
October 10, 2016: Revista Latino-americana de Enfermagem
https://www.readbyqxmd.com/read/27724859/a-period-of-immobility-after-remifentanil-administration-protects-from-nausea-an-experimental-randomized-cross-over-study
#14
Fabian Heuser, Christian M Schulz, Alexander Hapfelmeier, Nadine Lehnen, Eberhard F Kochs, Klaus J Wagner
BACKGROUND: The opioid remifentanil induces a decrease of vestibulo-ocular reflex function, which has been associated with nausea and vomiting when the subjects are moved. The study investigates in healthy female volunteers if immobility after remifentanil administration protects from nausea and vomiting. METHODS: In volunteers, a standardized movement intervention (a manually applied head-trunk movement forward, backward and sideward) was started 5 min (session A), 35 min (session B) or 60 min (session C) after cessation of a remifentanil infusion (0...
October 10, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27720226/circadian-time-sickness-time-of-day-cue-conflicts-directly-affect-health
#15
Raymond van Ee, Sander Van de Cruys, Luc J M Schlangen, Björn N S Vlaskamp
A daily rhythm that is not in synchrony with the environmental light-dark cycle (as in jetlag and shift work) is known to affect mood and health through an as yet unresolved neural mechanism. Here, we combine Bayesian probabilistic 'cue-conflict' theory with known physiology of the biological clock of the brain, entailing the insight that, for a functional pacemaker, it is sufficient to have two interacting units (reflecting environmental and internal time-of-day cues), without the need for an extra homuncular directing unit...
October 5, 2016: Trends in Neurosciences
https://www.readbyqxmd.com/read/27683882/the-response-of-the-vestibulosympathetic-reflex-to-linear-acceleration-in-the-rat
#16
S B Yakushin, G P Martinelli, T Raphan, B Cohen
The vestibulosympathetic reflex (VSR) increases blood pressure (BP) upon arising to maintain blood flow to the brain. The optimal directions of VSR activation and whether changes in heart rate (HR) are associated with changes in BP are still not clear. We used manually activated pulses and oscillatory linear accelerations of 0.2-2.5 g along the naso-occipital, interaural, and dorsoventral axes in isoflurane-anesthetized, male Long-Evans rats. BP and HR were recorded with an intra-aortic sensor and acceleration with a three-dimensional accelerometer...
December 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27662351/screening-and-mitigation-of-layperson-anxiety-in-aerospace-environments
#17
REVIEW
Robert A Mulcahy, Rebecca S Blue, Johnené L Vardiman, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: Anxiety may present challenges for commercial spaceflight operations, as little is known regarding the psychological effects of spaceflight on laypersons. A recent investigation evaluated measures of anxiety during centrifuge-simulated suborbital commercial spaceflight, highlighting the potential for severe anxiousness to interrupt spaceflight operations. METHODS: To pave the way for future research, an extensive literature review identified existing knowledge that may contribute to formation of interventions for anxiety in commercial spaceflight...
2016: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/27644633/efficacy-of-ginger-in-control-of-chemotherapy-induced-nausea-and-vomiting-in-breast-cancer-patients-receiving-doxorubicin-based-chemotherapy
#18
Mansour Ansari, Pezhman Porouhan, Mohammad Mohammadianpanah, Shapour Omidvari, Ahmad Mosalaei, Niloofar Ahmadloo, Hamid Nasrollahi, Seyed Hasan Hamedi
Nausea and vomiting are among the most serious side effects of chemotherapy, in some cases leading to treatment interruption or chemotherapy dose reduction. Ginger has long been known as an antiemetic drug, used for conditions such as motion sickness, nausea-vomiting in pregnancy, and post-operation side effects. One hundred and fifty female patients with breast cancer entered this prospective study and were randomized to receive ginger (500 mg ginger powder, twice a day for 3 days) or placebo. One hundred and nineteen patients completed the study: 57 of them received ginger and 62 received ginger for the frst 3 chemotherapy cycles...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27641791/the-influence-of-sleep-deprivation-and-oscillating-motion-on-sleepiness-motion-sickness-and-cognitive-and-motor-performance
#19
REVIEW
Janna Kaplan, Joel Ventura, Avijit Bakshi, Alberto Pierobon, James R Lackner, Paul DiZio
Our goal was to determine how sleep deprivation, nauseogenic motion, and a combination of motion and sleep deprivation affect cognitive vigilance, visual-spatial perception, motor learning and retention, and balance. We exposed four groups of subjects to different combinations of normal 8h sleep or 4h sleep for two nights combined with testing under stationary conditions or during 0.28Hz horizontal linear oscillation. On the two days following controlled sleep, all subjects underwent four test sessions per day that included evaluations of fatigue, motion sickness, vigilance, perceptual discrimination, perceptual learning, motor performance and learning, and balance...
January 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/27638086/mal-de-d%C3%A3-barquement-syndrome
#20
T C Hain, M Cherchi
Mal de débarquement syndrome (MdDS) is typified by a prolonged rocking sensation - for a month or longer - that begins immediately following a lengthy exposure to motion. The provoking motion is usually a sea voyage. About 80% of MdDS sufferers are women, and most of them are middle-aged. MdDS patients are troubled by more migraine headaches than controls. Unlike dizziness caused by vestibular disorders or motion sickness, the symptoms of MdDS usually improve with re-exposure to motion. The long duration of symptoms - a month or more - distinguishes MdDS from land-sickness...
2016: Handbook of Clinical Neurology
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