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Motion sickness

Ranmalee Eramudugolla, Jasmine Price, Sidhant Chopra, Xiaolan Li, Kaarin J Anstey
OBJECTIVES: To design a low-cost simulator-based driving assessment for older adults and to compare its validity with that of an on-road driving assessment and other measures of older driver risk. DESIGN: Cross-sectional observational study. SETTING: Canberra, Australia. PARTICIPANTS: Older adult drivers (N = 47; aged 65-88, mean age 75.2). MEASUREMENTS: Error rate on a simulated drive with environment and scoring procedure matched to those of an on-road test...
October 22, 2016: Journal of the American Geriatrics Society
Masaki Matsushita, Kenichi Mishima, Ryusaku Esaki, Naoki Ishiguro, Kinji Ohno, Hiroshi Kitoh
OBJECTIVE Achondroplasia (ACH) is the most common short-limbed skeletal dysplasia caused by gain-of-function mutations in the fibroblast growth factor receptor 3 (FGFR3) gene. Foramen magnum stenosis (FMS) is one of the serious neurological complications in ACH. Through comprehensive drug screening, the authors identified that meclozine, an over-the-counter drug for motion sickness, inhibited activation of FGFR3 signaling. Oral administration of meclozine to the growing ACH mice promoted longitudinal bone growth, but it did not prevent FMS...
October 21, 2016: Journal of Neurosurgery. Pediatrics
Aline Maria Bonini Moysés, Lais Corsino Durant, Ana Maria de Almeida, Thais de Oliveira Gozzo
Objective: to identify factors related to the nursing diagnosis nausea among cancer patients undergoing chemotherapy. Method: integrative review conducted in four electronic databases (PUBMED, EMBASE, CINAHL and LILACS) using the key words: neoplasia, antineoplastic agents and nausea. Results: only 30 out of 1,258 papers identified met the inclusion criteria. The most frequent related factors were: being younger than 50 years old, motion sickness, being a woman, emetogenic potential of the chemotherapy, anxiety, conditioned stimulus, and expecting nausea after treatment...
October 10, 2016: Revista Latino-americana de Enfermagem
Fabian Heuser, Christian M Schulz, Alexander Hapfelmeier, Nadine Lehnen, Eberhard F Kochs, Klaus J Wagner
BACKGROUND: The opioid remifentanil induces a decrease of vestibulo-ocular reflex function, which has been associated with nausea and vomiting when the subjects are moved. The study investigates in healthy female volunteers if immobility after remifentanil administration protects from nausea and vomiting. METHODS: In volunteers, a standardized movement intervention (a manually applied head-trunk movement forward, backward and sideward) was started 5 min (session A), 35 min (session B) or 60 min (session C) after cessation of a remifentanil infusion (0...
October 10, 2016: BMC Anesthesiology
Raymond van Ee, Sander Van de Cruys, Luc J M Schlangen, Björn N S Vlaskamp
A daily rhythm that is not in synchrony with the environmental light-dark cycle (as in jetlag and shift work) is known to affect mood and health through an as yet unresolved neural mechanism. Here, we combine Bayesian probabilistic 'cue-conflict' theory with known physiology of the biological clock of the brain, entailing the insight that, for a functional pacemaker, it is sufficient to have two interacting units (reflecting environmental and internal time-of-day cues), without the need for an extra homuncular directing unit...
October 5, 2016: Trends in Neurosciences
Sergei B Yakushin, Giorgio P Martinelli, Theodore Raphan, Bernard Cohen
The vestibulo-sympathetic reflex (VSR) increases blood pressure (BP) upon arising to maintain blood flow to the brain. The optimal directions of VSR activation and whether there are changes in heart rate (HR) are still not clear. This was studied with manually-driven translations, which had pulses and oscillatory linear accelerations of 0.2-2.5 g along the naso-occipital, interaural, and dorso-ventral axes in Isoflurane-anesthetized male, Long-Evans rats. BP and HR were recorded with intra-aortic sensors and accelerationd with 3-D linear accelerometer...
September 28, 2016: Journal of Neurophysiology
Robert A Mulcahy, Rebecca S Blue, Johnené L Vardiman, Tarah L Castleberry, James M Vanderploeg
INTRODUCTION: Anxiety may present challenges for commercial spaceflight operations, as little is known regarding the psychological effects of spaceflight on laypersons. A recent investigation evaluated measures of anxiety during centrifuge-simulated suborbital commercial spaceflight, highlighting the potential for severe anxiousness to interrupt spaceflight operations. METHODS: To pave the way for future research, an extensive literature review identified existing knowledge that may contribute to formation of interventions for anxiety in commercial spaceflight...
2016: Aerospace Medicine and Human Performance
Mansour Ansari, Pezhman Porouhan, Mohammad Mohammadianpanah, Shapour Omidvari, Ahmad Mosalaei, Niloofar Ahmadloo, Hamid Nasrollahi, Seyed Hasan Hamedi
Nausea and vomiting are among the most serious side effects of chemotherapy, in some cases leading to treatment interruption or chemotherapy dose reduction. Ginger has long been known as an antiemetic drug, used for conditions such as motion sickness, nausea-vomiting in pregnancy, and post-operation side effects. One hundred and fifty female patients with breast cancer entered this prospective study and were randomized to receive ginger (500 mg ginger powder, twice a day for 3 days) or placebo. One hundred and nineteen patients completed the study: 57 of them received ginger and 62 received ginger for the frst 3 chemotherapy cycles...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Janna Kaplan, Joel Ventura, Avijit Bakshi, Alberto Pieobon, James R Lackner, Paul DiZio
Our goal was to determine how sleep deprivation, nauseogenic motion, and a combination of motion and sleep deprivation affect cognitive vigilance, visual-spatial perception, motor learning and retention, and balance. We exposed four groups of subjects to different combinations of normal 8h sleep or 4h sleep for two nights combined with testing under stationary conditions or during 0.28Hz horizontal linear oscillation. On the two days following controlled sleep, all subjects underwent four test sessions per day that included evaluations of fatigue, motion sickness, vigilance, perceptual discrimination, perceptual learning, motor performance and learning, and balance...
August 31, 2016: Autonomic Neuroscience: Basic & Clinical
T C Hain, M Cherchi
Mal de débarquement syndrome (MdDS) is typified by a prolonged rocking sensation - for a month or longer - that begins immediately following a lengthy exposure to motion. The provoking motion is usually a sea voyage. About 80% of MdDS sufferers are women, and most of them are middle-aged. MdDS patients are troubled by more migraine headaches than controls. Unlike dizziness caused by vestibular disorders or motion sickness, the symptoms of MdDS usually improve with re-exposure to motion. The long duration of symptoms - a month or more - distinguishes MdDS from land-sickness...
2016: Handbook of Clinical Neurology
J F Golding
Over 2000 years ago the Greek physician Hippocrates wrote, "sailing on the sea proves that motion disorders the body." Indeed, the word "nausea" derives from the Greek root word naus, hence "nautical," meaning a ship. The primary signs and symptoms of motion sickness are nausea and vomiting. Motion sickness can be provoked by a wide variety of transport environments, including land, sea, air, and space. The recent introduction of new visual technologies may expose more of the population to visually induced motion sickness...
2016: Handbook of Clinical Neurology
Bing Zhang, Pan Hu, Kun-Lun Yu, Jiang-Bo Bai, De-Hu Tian, Gui-Sheng Zhang, Xin-Zhong Shao, Ying-Ze Zhang
OBJECTIVE: This study aimed to compare the clinical and radiologic outcomes of AO titanium locking plate and screw (ATLPS) and anterograde intramedullary (AIM) fixation for treating unstable metacarpal and phalangeal fractures. METHODS: Adult patients with isolated fresh unstable metacarpal and phalangeal fractures who met the inclusion criteria were enrolled into this prospective study from July 2013. Patients were divided into ATLPS or AIM groups when they were admitted to our department after considering their work requirement, fracture complexity, and surgeon's experience and were then treated accordingly...
August 2016: Orthopaedic Surgery
James B Lucot
Doses of naloxone far below those which elicit emesis increase the sensitivity to motion sickness. In order to evaluate the possible interaction with broad spectrum antiemetics, low doses of naloxone were tested alone and in combination with 8-hydroxy-2-(di-n-propylamine)tetralin (DPAT), fentanyl and the NK1 antagonist CP-99994. A modified autonomic symptom rating scale was unaffected by any drug and thus considered of little value. Fentanyl and NK1 antagonists decreased the duration of the retch/vomit sequence...
August 30, 2016: Autonomic Neuroscience: Basic & Clinical
Emilio Madrigal, Shyam Prajapati, Juan C Hernandez-Prera
OBJECTIVES: A proper examination of surgical specimens is fundamental in anatomic pathology (AP) education. However, the resources available to residents may not always be suitable for efficient skill acquisition. We propose a method to enhance AP education by introducing high-definition videos featuring methods for appropriate specimen handling, viewable on two-dimensional (2D) and stereoscopic three-dimensional (3D) platforms. METHODS: A stereo camera system recorded the gross processing of commonly encountered specimens...
October 2016: American Journal of Clinical Pathology
Abolfazl Aslani, Alireza Ghannadi, Farnaz Rostami
BACKGROUND: Various ginger compounds improve gastrointestinal problems and motion sickness. The main effects of ginger allocate to some phenolics such as gingerols and shogaols that act as their active agents. Chewing gums are among convenient dosage forms which patients prefer due to their advantages. Hence, this study tried to design, formulate, and evaluate ginger chewing gum of favorable taste and texture to avoid motion sickness and have gastro-protective and anti-oxidant effect...
2016: Advanced Biomedical Research
S Jain, D Nagarjuna, R Gaind, S Chopra, P K Debata, R Dawar, R Sardana, M Yadav
Escherichia vulneris is an opportunistic human pathogen. It has been primarily reported in adult patients and invasive infections have been observed in immune-suppressed individuals. This is the first report of E. vulneris causing complicated diarrhoea and sepsis in an infant. Two month old sick infant, born full-term, was admitted to the paediatrics department with loose motions and refusal to feed for four days. E. vulneris was isolated from blood in pure culture. The isolate was characterized for diarrhoeal virulence markers: heat labile and heat stable toxins (LT, ST) and hemolysin (hlyA) by PCR...
September 2016: New Microbes and New Infections
Aik Hoe Yeoh, Shereen Suet Ping Tang, Norsidah Abdul Manap, Wan Rahiza Wan Mat, Shuraya Said, Muhamad Rahimi Che Hassan, Raha Abdul Rahman
BACKGROUND/AIM: The effects of pericardium 6 (P6) electrical stimulation in patients at risk of postoperative nausea and vomiting (PONV) following laparoscopic surgery were evaluated. MATERIALS AND METHODS: Eighty patients for laparoscopic surgery with at least one of the determined risks (nonsmoker, female, previous PONV/motion sickness, or postoperative opioid use) were randomized into either an active or sham group. At the end of surgery, Reletex electrical acustimulation was placed at the P6 acupoint...
2016: Turkish Journal of Medical Sciences
Adrián Borrego, Jorge Latorre, Roberto Llorens, Mariano Alcañiz, Enrique Noé
BACKGROUND: Even though virtual reality (VR) is increasingly used in rehabilitation, the implementation of walking navigation in VR still poses a technological challenge for current motion tracking systems. Different metaphors simulate locomotion without involving real gait kinematics, which can affect presence, orientation, spatial memory and cognition, and even performance. All these factors can dissuade their use in rehabilitation. We hypothesize that a marker-based head tracking solution would allow walking in VR with high sense of presence and without causing sickness...
2016: Journal of Neuroengineering and Rehabilitation
Amelia Kinsella, Ryan Mattfeld, Eric Muth, Adam Hoover
BACKGROUND: Interactions between frequency and amplitude of latency in head-mounted displays (HMDs) are thought to affect simulator sickness. Many studies have linked system latency to subjective sickness, but recent research has found that at least with the case of inertia-based head tracking technology, latency is not a constant; rather it varies systematically over time due to sensor errors and clock asynchronization. The purpose of this experiment was to further explore the relationship between frequency and amplitude of latency as they relate to subjective sickness experienced in an HMD...
July 2016: Aerospace Medicine and Human Performance
Thomas Brandt, Matthias Bauer, Judy Benson, Doreen Huppert
OBJECTIVE: To find and analyze descriptions of motion sickness in Chinese historical sources. METHODS: Databases and dictionaries were searched for various terms for seasickness and travel sickness, which were then entered into databases of full texts allowing selection of relevant passages from about the third to the 19th century ad. RESULTS: Already in 300 ad the Chinese differentiated cart-sickness, particularly experienced by persons from the arid north of China, from a ship-illness experienced by persons from the south, where rivers were important for transportation and travel...
July 19, 2016: Neurology
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