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Prophylactic Mastectomy

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https://www.readbyqxmd.com/read/28058563/long-term-satisfaction-and-body-image-after-contralateral-prophylactic-mastectomy
#1
Chelsea Anderson, Jessica Y Islam, M Elizabeth Hodgson, Susan A Sabatino, Juan L Rodriguez, Clara N Lee, Dale P Sandler, Hazel B Nichols
BACKGROUND: Contralateral prophylactic mastectomy (CPM) rates have been increasing in the US, and although high levels of satisfaction with CPM have been reported, few studies have evaluated the long-term effects on body image, comparing CPM with breast-conserving surgery (BCS) and unilateral mastectomy (UM). METHODS: We analyzed responses from a survey of women with both a personal and family history of breast cancer who were enrolled in the Sister Study (n = 1176)...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28058555/commentary-on-the-consensus-statement-of-the-american-society-of-breast-surgeons-on-contralateral-prophylactic-mastectomy
#2
EDITORIAL
Sharyl J Nass, Larissa Nekhlyudov
The increasing rate of contralateral prophylactic mastectomy (CPM) led the American Society of Breast Surgeons (ASBrS) to issue an evidence-based consensus statement on CPM, as well as a discussion guide that health care providers can use to facilitate shared decision making with patients considering CPM for unilateral breast cancer. This article suggests several ways to improve the discussion guide by eliciting patient values and preferences and by providing more current, detailed, and balanced information about the potential risks and benefits of CPM...
January 5, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28013324/legislation-regulating-availability-of-breast-cancer-treatment-with-particular-focus-on-prophylactic-mastectomy
#3
Paulina Rolska, Jolanta Łapa
Breast cancer is one of the most common diseases in the Polish society. In 2015, around 17,000 Polish women were diagnosed with this type of cancer. A comparison of relative survival rates for different European countries shows that the Polish oncological care system is inefficient in terms of breast cancer treatment. Women in Poland have substantially lower chances of surviving the first five years a er being diagnosed than women in most other European countries. An inspiration, and at the same time the main theme of the paper is assessing the availability of a controversial treatment, i...
2016: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/28002558/contralateral-prophylactic-mastectomy-aligning-patient-preferences-and-provider-recommendations
#4
Oluwadamilola M Fayanju, E Shelley Hwang
No abstract text is available yet for this article.
December 21, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/28002555/contralateral-prophylactic-mastectomy-decisions-in-a-population-based-sample-of-patients-with-early-stage-breast-cancer
#5
Reshma Jagsi, Sarah T Hawley, Kent A Griffith, Nancy K Janz, Allison W Kurian, Kevin C Ward, Ann S Hamilton, Monica Morrow, Steven J Katz
Importance: Contralateral prophylactic mastectomy (CPM) use is increasing among women with unilateral breast cancer, but little is known about treatment decision making or physician interactions in diverse patient populations. Objective: To evaluate patient motivations, knowledge, and decisions, as well as the impact of surgeon recommendations, in a large, diverse sample of patients who underwent recent treatment for breast cancer. Design, Setting, and Participants: A survey was sent to 3631 women with newly diagnosed, unilateral stage 0, I, or II breast cancer between July 2013 and September 2014...
December 21, 2016: JAMA Surgery
https://www.readbyqxmd.com/read/27975014/the-nipple-areola-preserving-mastectomy-the-value-of-adding-a-delay-procedure
#6
Carlos A Martinez, Scott M Reis, Sean G Boutros
BACKGROUND: Conservative mastectomy procedures, such as the nipple-sparing mastectomy (NSM), present appealing options for patients with small invasive or noninvasive malignancies and those needing prophylactic mastectomies. Despite outstanding postoperative cosmetic results, nipple-areola complex (NAC) and mastectomy skin flap (MSF) survival remains a concern. We present our two-stage nipple-areola preserving (NAP) mastectomy, which aims to decrease the rate of NAC loss and MSF necrosis after conservative mastectomies...
November 2016: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/27969575/women-s-preferences-for-contralateral-prophylactic-mastectomy-following-unilateral-breast-cancer-what-risk-reduction-makes-it-worthwhile
#7
Stephanie Tesson, Imogen Richards, David Porter, Kelly-Anne Phillips, Nicole Rankin, Daniel Costa, Toni Musiello, Michelle Marven, Phyllis Butow
OBJECTIVES: Contralateral prophylactic mastectomy (CPM) reduces the risk of contralateral breast cancer (BC) following unilateral BC, but may not increase survival in BRCA1/2 mutation negative women. Despite this, and the risk for adverse physical and psychological impact, uptake is increasing in BRCA1/2 mutation negative women. We aimed to quantify the degree of reduction in lifetime contralateral BC risk women required to justify CPM, and to explore demographic, disease and psychosocial predictors of preferences using Protection Motivation Theory (PMT) as a theoretical framework...
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27933411/society-of-surgical-oncology-breast-disease-working-group-statement-on-prophylactic-risk-reducing-mastectomy
#8
Kelly K Hunt, David M Euhus, Judy C Boughey, Anees B Chagpar, Sheldon M Feldman, Nora M Hansen, Swati A Kulkarni, David R McCready, Eleftherios P Mamounas, Lee G Wilke, Kimberly J Van Zee, Monica Morrow
Over the past several years, there has been an increasing rate of bilateral prophylactic mastectomy (BPM) and contralateral prophylactic mastectomy (CPM) surgeries. Since publication of the 2007 SSO position statement on the use of risk-reducing mastectomy, there have been significant advances in the understanding of breast cancer biology and treatment. The purpose of this manuscript is to review the current literature as a resource to facilitate a shared and informed decision-making process regarding the use of risk-reducing mastectomy...
February 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27931006/brca-mutation-genetic-testing-implications-in-the-united-states
#9
REVIEW
Soley Bayraktar, Banu Arun
BRCA mutation carriers have a very high risk of breast and ovarian cancer by age 70, in the ranges 47%-66% and 40%-57%, respectively. Additionally, women with BRCA mutation-associated breast cancer also have an elevated risk of other or secondary malignancies. Fortunately, the breast and ovarian cancer outcome for BRCA1/2 mutation carriers is at least as good as for non-carriers with chemoprevention, prophylactic surgeries and appropriate use of therapies. Therefore, identification of those who might have a mutation is important so that genetic counseling, testing, screening and prevention strategies can be applied in a timely manner...
February 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/27922795/breast-cancer-risk-reduction-decisions-of-the-brca-positive-patient-an-observational-study-at-a-single-institution
#10
Dana Johns, Jay Agarwal, Layla Anderson, Jian Ying, Wendy Kohlmann
BACKGROUND: BRCA1 and BRCA2 gene mutations carry with them a 50%-80% risk of developing breast cancer. The best choice for managing breast cancer risk in patients with a BRCA1/2 mutation is a highly personal decision. Options for risk management include surveillance with multiple modalities or prophylactic surgical intervention. The goal of this study was to gain a better understanding of contributing factors affecting the decision for managing breast cancer risk made by patients who are BRCA mutation positive and cancer free...
December 6, 2016: Journal of Women's Health
https://www.readbyqxmd.com/read/27893634/comparison-of-different-acellular-dermal-matrix-adm-in-breast-reconstruction-the-50-50-study
#11
Troy A Pittman, Kenneth L Fan, Andrew Knapp, Shelby Frantz, Scott L Spear
BACKGROUND: Acellular Dermal Matrix (ADM) has enjoyed extensive use in primary and secondary alloplastic breast aesthetic and reconstructive surgery. The objective of this study is to examine clinical outcomes between available ADM: DermACELL(LifeNet Health, Virginia Beach, VA) and AlloDerm RTU (LifeCell, Branchburg, New Jersey). METHODS: A retrospective chart review was performed on 58 consecutive patients (100 breasts) reconstructed with either DermACELL(n=30 patients; 50 breasts) or AlloDerm RTU (n=28 patients; 50 breasts)...
November 21, 2016: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27867298/prophylactic-bilateral-nipple-sparing-mastectomy-and-a-staged-breast-reconstruction-technique-preliminary-results
#12
Thierry Tondu, Filip Thiessen, Wiebren A A Tjalma
More high-risk women with breast cancer are identified using genetic testing at a younger age. These young women often opt for prophylactic surgery. Most patients are reluctant for extra donor-site scars besides infections and necrosis. In order to reduce these risks, a two-stage breast reconstruction technique is used for high-risk women with large or ptotic breasts. We presume that this procedure will reduce the risk of skin envelope and nipple-areola complex (NAC) necrosis to less than 1%. In the first stage, an inferior pedicle reduction is performed to obtain large volume reduction with maximal safety for the NAC...
2016: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/27845965/the-necessity-of-the-nipple-redefining-completeness-in-breast-reconstruction
#13
E Hope Weissler, Julie B Schnur, Andreas M Lamelas, Marisa Cornejo, Elan Horesh, Peter J Taub
INTRODUCTION: Satisfaction with breast reconstruction is thought to be greatest among patients who complete nipple and areolar complex (NAC) reconstruction. Anecdotally, many patients are known to decline NAC reconstruction. The authors aimed to characterize the epidemiology of and factors associated with incomplete breast reconstruction. METHODS: Breast reconstruction patients with follow-up in a single institution's electronic medical record system were reviewed...
November 15, 2016: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/27817227/-evaluation-of-clinicopathological-findings-and-cosmetic-outcome-of-100-immediate-postmastectomy-breast-reconstruction-cases
#14
Dávid Pukancsik, Péter Kelemen, Ákos Sávolt, Mihály Újhelyi, Eszter Kovács, Zoltán Zaka, Miklós Kásler, Zoltán Mátrai
INTRODUCTION: Immediate breast reconstruction provides oncological safety, requires longer operation time. It does not influence the initiation of adjuvant therapy and radiological control, and results in favourable cosmetic outcome. AIM: Assessing the Hungarian data of immediate postmastectomy breast reconstructions, and comparing them to international findings. METHOD: Between May, 2011 and September, 2014 121 therapeutic and prophylactic, postmastectomy immediate breast reconstructions were performed in 100 patients...
November 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27815748/a-model-for-individualized-risk-prediction-of-contralateral-breast-cancer
#15
Marzana Chowdhury, David Euhus, Tracy Onega, Swati Biswas, Pankaj K Choudhary
PURPOSE: Patients diagnosed with invasive breast cancer (BC) or ductal carcinoma in situ are increasingly choosing to undergo contralateral prophylactic mastectomy (CPM) to reduce their risk of contralateral BC (CBC). This is a particularly disturbing trend as a large proportion of these CPMs are believed to be medically unnecessary. Many BC patients tend to substantially overestimate their CBC risk. Thus, there is a pressing need to educate patients effectively on their CBC risk. We develop a CBC risk prediction model to aid physicians in this task...
January 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/27787313/new-advisory-on-contralateral-prophylactic-mastectomy
#16
Joan Zolot
Breast surgeons recommend against the procedure unless cancer risk is increased.
November 2016: American Journal of Nursing
https://www.readbyqxmd.com/read/27783164/guidelines-for-guidelines-an-assessment-of-the-american-society-of-breast-surgeons-contralateral-prophylactic-mastectomy-consensus-statement
#17
EDITORIAL
Todd M Tuttle, Andrea V Barrio, V Suzanne Klimberg, Armando E Giuliano, Mariana Chavez-MacGregor, Heather A Thompson Buum, Kelly M McMasters
No abstract text is available yet for this article.
January 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27779988/is-sentinel-lymph-node-dissection-necessary-in-all-patients-with-ductal-carcinoma-in-situ-undergoing-total-mastectomy
#18
Valentina Bonev, Carlos Chavez De Paz Villanueva, Naveenraj Solomon, Maheswari Senthil, Mark E Reeves, Carlos Garberoglio, Sharon S Lum
When ductal carcinoma in situ (DCIS) is found on core needle biopsy, rates of upgrade to invasive cancer of 25 per cent and nodal positivity of 10 per cent have been reported. Sentinel lymph node dissection (SLND) is recommended when mastectomy is performed for DCIS. We investigated the role of SLND in DCIS patients undergoing partial and total mastectomy (TM). During the study period 2004 to 2013, 170 patients with DCIS were identified with a median age of 60 years (range 26-84 years). Of these, 58.2 per cent had partial mastectomy (PM) alone, 10...
October 2016: American Surgeon
https://www.readbyqxmd.com/read/27776557/mammographically-dense-human-breast-tissue-stimulates-mcf10dcis-com-progression-to-invasive-lesions-and-metastasis
#19
Cecilia W Huo, Mark Waltham, Christine Khoo, Stephen B Fox, Prue Hill, Shou Chen, Grace L Chew, John T Price, Chau H Nguyen, Elizabeth D Williams, Michael Henderson, Erik W Thompson, Kara L Britt
BACKGROUND: High mammographic density (HMD) not only confers a significantly increased risk of breast cancer (BC) but also is associated with BCs of more advanced stages. However, it is unclear whether BC progression and metastasis are stimulated by HMD. We investigated whether patient-derived HMD breast tissue could stimulate the progression of MCF10DCIS.com cells compared with patient-matched low mammographic density (LMD) tissue. METHODS: Sterile breast specimens were obtained immediately after prophylactic mastectomy from high-risk women (n = 10)...
October 25, 2016: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/27737975/identification-and-management-of-women-with-a-family-history-of-breast-cancer-practical-guide-for-clinicians
#20
REVIEW
Ruth Heisey, June C Carroll
OBJECTIVE: To summarize the best evidence on strategies to identify and manage women with a family history of breast cancer. SOURCES OF INFORMATION: A PubMed search was conducted using the search terms breast cancer, guidelines, risk, family history, management, and magnetic resonance imaging screening from 2000 to 2016. Most evidence is level II. MAIN MESSAGE: Taking a good family history is essential when assessing breast cancer risk in order to identify women suitable for referral to a genetic counselor for possible genetic testing...
October 2016: Canadian Family Physician Médecin de Famille Canadien
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