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Malik Nassan, Qingqin Li, Paul E Croarkin, Wenan Chen, Colin L Colby, Marin Veldic, Susan L McElroy, Gregory D Jenkins, Euijung Ryu, Julie M Cunningham, Marion Leboyer, Mark A Frye, Joanna M Biernacka
BACKGROUND: Although multiple genes have been implicated in bipolar disorder (BD), they explain only a small proportion of its heritability. Identifying additional BD risk variants may be impaired by phenotypic heterogeneity, which is usually not taken into account in genome-wide association studies (GWAS). BD with early age at onset is a more homogeneous familial form of the disorder associated with greater symptom severity. METHODS: We conducted a GWAS of early-onset BD (onset of mania/hypomania ≤19 years old) in a discovery sample of 419 cases and 1034 controls and a replication sample of 181 cases and 777 controls...
September 30, 2016: Journal of Affective Disorders
Cremildo João Baptista, Ines Dourado, Sandra Brignol, Tarcísio de Matos Andrade, Francisco Inácio Bastos
BACKGROUND: The burden of sexually transmitted infections (STIs), such as syphilis, is higher in low-income countries, with serious consequences and profound impact on sexual and reproductive health and human immunodeficiency virus (HIV) spread. Syphilis prevalence tend to be higher among people who misuse drugs than in the general population. OBJECTIVE: To assess syphilis and associated factors among polydrug users (PDU) in the city of Salvador, Northeast Brazil...
October 18, 2016: International Journal on Drug Policy
Elvira Boere, Astrid M Kamperman, Arianne E van 't Hoog, Walter W van den Broek, Tom K Birkenhäger
Electroconvulsive therapy (ECT) is considered an effective treatment for major depression with melancholic features. However, neurocognitive side-effects such as anterograde amnesia still regularly occur. The present study aims to evaluate the severity and course of anterograde amnesia in severely depressed patients undergoing ECT. In a prospective naturalistic study, anterograde memory function was assessed among inpatients who underwent ECT (n = 11). Subjects met DSM-IV criteria for major depressive disorder...
2016: PloS One
Murat Altinay, Harish Karne, Erik Beall, Amit Anand
BACKGROUND: This study investigated extended release quetiapine (quetiapine XR) associated changes in functional MRI (fMRI) measures of task-induced amygdalar activation and resting state connectivity in anxious unipolar major depressive disorder (AMDD). METHODS: Anxious unipolar major depressive disorder patients (n = 15) (17-item Hamilton Depression Rating Scale (HAM-D) >18 and Hamilton Anxiety Scale (HAM-A) >18) and closely matched healthy control (HC) subjects were compared at baseline for task induced amygdala activation and resting state connectivity on fMRI...
October 21, 2016: Journal of Clinical Psychopharmacology
Nehemiah T Liu, José Salinas, Craig A Fenrich, Maria L Serio-Melvin, George C Kramer, Ian R Driscoll, Martin A Schreiber, Leopoldo C Cancio, Kevin K Chung
INTRODUCTION: The depth of burn has been an important factor often overlooked when estimating the total resuscitation fluid needed for early burn care. The goal of this study was to determine the degree to which full-thickness (FT) involvement affected overall 24-hour burn resuscitation volumes. METHODS: We performed a retrospective review of patients admitted to our burn intensive care unit from December 2007 to April 2013, with significant burns that required resuscitation using our computerized decision support system for burn fluid resuscitation...
November 2016: Journal of Trauma and Acute Care Surgery
Joshua F Wiley, Bei Bei, Julienne E Bower, Annette L Stanton
OBJECTIVES: Allostatic load (AL) represents cumulative wear-and-tear on the body and is operationalized as a multisystem index of biomarkers. Allostatic load is associated with morbidities and mortality, leading to a growing body of literature that uses AL as an outcome in its own right. Psychosocial resources (PSRs), such as mastery and social support, may influence health outcomes in part via AL, and the current review seeks to characterize the relations between PSRs and AL. METHODS: A systematic review was conducted by searching PubMed, CINAHL Plus, PsycINFO, Scopus, and Embase for studies examining the relation between PSR(s) and AL in humans...
October 20, 2016: Psychosomatic Medicine
Jill Cox, Loretta Kaes, Miguel Martinez, Daniel Moles
Skin temperature may help prospectively determine whether an area of skin discoloration will evolve into necrosis. A prospective, observational study was conducted in 7 skilled nursing facilities to determine if skin temperature measured using infrared thermography could predict the progression of discolored intact skin (blanchable erythema, Stage 1 pressure ulcer, or sus- pected deep tissue injury [sDTI]) to necrosis and to evaluate if nurses could effectively integrate thermography into the clinical setting...
October 2016: Ostomy/wound Management
Margaret E Hunter, Robert M Dorazio, John S S Butterfield, Gaia Meigs-Friend, Leo G Nico, Jason A Ferrante
A set of universal guidelines is needed to determine the limit of detection (LOD) in PCR-based analyses of low concentration DNA. In particular, environmental DNA (eDNA) studies require sensitive and reliable methods to detect rare and cryptic species through shed genetic material in environmental samples. Current strategies for assessing detection limits of eDNA are either too stringent or subjective, possibly resulting in biased estimates of species' presence. Here, a conservative LOD analysis grounded in analytical chemistry is proposed to correct for overestimated DNA concentrations predominantly caused by the concentration plateau, a nonlinear relationship between expected and measured DNA concentrations...
October 21, 2016: Molecular Ecology Resources
Bruno Facon, David Magis
Purpose: An item analysis of Bishop's (1983) Test for Reception of Grammar (TROG) in its French version (F-TROG; Lecocq, 1996) was conducted to determine whether the difficulty of items is similar for participants with or without intellectual disability (ID). Method: In Study 1, responses to the 92 F-TROG items by 55 participants with Down syndrome (DS), 55 with ID of undifferentiated etiology (UND), and 55 typical children (TYP) matched on their F-TROG total score were compared using the transformed item difficulties method, a statistical approach designed to detect differential item functioning (DIF) between groups...
October 20, 2016: Journal of Speech, Language, and Hearing Research: JSLHR
Shashidhara Marathe, Xianbo Shi, Michael J Wojcik, Albert T Macrander, Lahsen Assoufid
A procedure for a technique to measure the transverse coherence of synchrotron radiation X-ray sources using a single phase grating interferometer is reported. The measurements were demonstrated at the 1-BM bending magnet beamline of the Advanced Photon Source (APS) at Argonne National Laboratory (ANL). By using a 2-D checkerboard π/2 phase-shift grating, transverse coherence lengths were obtained along the vertical and horizontal directions as well as along the 45° and 135° directions to the horizontal direction...
October 11, 2016: Journal of Visualized Experiments: JoVE
Wei Zhang, M Can Gulersonmez, Thomas Hankemeier, Rawi Ramautar
In metabolomics, a wide range of analytical techniques is used for the global profiling of (endogenous) metabolites in complex samples. In this paper, a protocol is presented for the analysis of anionic and cationic metabolites in biological samples by capillary electrophoresis-mass spectrometry (CE-MS). CE is well-suited for the analysis of highly polar and charged metabolites as compounds are separated on the basis of their charge-to-size ratio. A recently developed sheathless interfacing design, i.e., a porous tip interface, is used for coupling CE to electrospray ionization (ESI) MS...
October 1, 2016: Journal of Visualized Experiments: JoVE
Haseong Kim, Gui Hwan Han, Yaoyao Fu, Jongsik Gam, Seung Goo Lee
Recent improvements in Förster resonance energy transfer (FRET) sensors have enabled their use to detect various small molecules including ions and amino acids. However, the innate weak signal intensity of FRET sensors is a major challenge that prevents their application in various fields and makes the use of expensive, high-end fluorometers necessary. Previously, we built a cost-effective, high-performance FRET analyzer that can specifically measure the ratio of two emission wavelength bands (530 and 480 nm) to achieve high detection sensitivity...
October 1, 2016: Journal of Visualized Experiments: JoVE
Szu-I Yeh, Wei-Feng Fang, Chao-Jyun Huang, Tzu-Ming Wang, Jing-Tang Yang
A simple and visual method to detect multi-nucleotide polymorphism (MNP) was performed on a pneumatic droplet manipulation platform on an open surface. This approach to colorimetric DNA detection was based on the hybridization-mediated growth of gold nanoparticle probes (AuNP probes). The growth size and configuration of the AuNP are dominated by the number of DNA samples hybridized with the probes. Based on the specific size- and shape-dependent optical properties of the nanoparticles, the number of mismatches in a sample DNA fragment to the probes is able to be discriminated...
September 27, 2016: Journal of Visualized Experiments: JoVE
Stephan Allgeier, Karsten Winter, Georg Bretthauer, Rudolf F Guthoff, Sabine Peschel, Klaus-Martin Reichert, Oliver Stachs, Bernd Köhler
: Purpose/Aim of the study: A recently proposed technique enables the generation of continuously increasing mosaic images of the corneal sub-basal nerve plexus (SNP) using in vivo corneal confocal microscopy (CCM). The aim of the present study was to investigate the progression of the corneal nerve fiber length (CNFL) measured in the growing mosaic images with regard to their increasing area. MATERIALS AND METHODS: Five large datasets from three healthy volunteers were examined using the proposed CCM technique...
October 21, 2016: Current Eye Research
Marcello Marelli, Claudio Evangelisti, Maria Vittoria Diamanti, Vladimiro Dal Santo, Mariapia Pedeferri, Claudia Letizia Bianchi, Luca Schiavi, Alberto Strini
A new protocol to synthesize size-controlled Au nanoparticles (NPs) loaded onto vertically aligned anatase TiO2 nanotubes arrays (TNTAs) prepared by electrochemical anodization is reported. Ligand-free Au NPs (< 10 nm) were deposited onto anatase TNTAs supports, finely tuning the Au loading by controlling the immersion time of the support into metal vapor synthesis (MVS)-derived Au-acetone solutions. The Au/TNTAs composites were characterized by electron microscopies (SEM, (S)TEM), X-ray diffraction, X-ray photoelectron spectroscopy and UV-Vis spectroscopy...
October 21, 2016: ACS Applied Materials & Interfaces
Shan Wang, Changmin Hou, Long Yuan, Mingyang Qu, Bo Zou, Dayong Lu
Perovskite structured rare-earth chromites are one of the most promising families of functional materials in solid oxide fuel cells, multiferroic materials, and sensors. Here, we report a mild hydrothermal method to synthesize DyCrO3 and HoCrO3 monodispersed single crystals. The synthesis conditions, crystal structure, Raman spectra and temperature- and field-dependent magnetic properties were studied. The two samples are indexed to the Pbnm space group. The shapes of the crystals are plates with a narrow particle size distribution in the range of 4-5 μm...
October 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Ádám Berniczei-Roykó, Jan-Hendrik Tappe, Axel Krinner, Tomasz Gredes, András Végh, Katona Gábor, Kamila Linkowska-Świdzińska, Ute Ulrike Botzenhart
BACKGROUND Cleft defects are one of the most frequent birth-deformities of the orofacial region and they are commonly associated with anomalies of the tooth structure, size, shape, formation, eruption, and tooth number. The aim of our study was to evaluate the prevalence, distribution, and potential association of combined hypodontia in cleft-affected patients with regard to all types of teeth in both jaws in the permanent dentition. MATERIAL AND METHODS This retrospective radiographic analysis included patients with various types of clefts treated orthodontically in the Department of Orofacial Orthopedics and Orthodontics at Heim Pàl Children's Hospital, Budapest...
October 21, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
A Gunst, D Ventus, A Kärnä, P Salo, P Jern
BACKGROUND: Most studies examining female sexual functions (FSFs) have used cross-sectional designs, not allowing for studying temporal stability and possible relationships between different FSFs over time. Our aim was to study these relationships using a longitudinal approach. METHOD: The study sample consisted of 2173 Finnish women from two large-scale, population-based data collections 7 years apart. The Female Sexual Function Index was used. Analyses were further conducted separately for women in different relationship constellations...
October 21, 2016: Psychological Medicine
Edmund R Glass, Mikhail G Dozmorov
BACKGROUND: The goal of many human disease-oriented studies is to detect molecular mechanisms different between healthy controls and patients. Yet, commonly used gene expression measurements from blood samples suffer from variability of cell composition. This variability hinders the detection of differentially expressed genes and is often ignored. Combined with cell counts, heterogeneous gene expression may provide deeper insights into the gene expression differences on the cell type-specific level...
October 6, 2016: BMC Bioinformatics
Marcos Nakamura-Pereira, Maria do Carmo Leal, Ana Paula Esteves-Pereira, Rosa Maria Soares Madeira Domingues, Jacqueline Alves Torres, Marcos Augusto Bastos Dias, Maria Elisabeth Moreira
BACKGROUND: Cesarean section (CS) rates are increasing worldwide but there is some concern with this trend because of potential maternal and perinatal risks. The Robson classification is the standard method to monitor and compare CS rates. Our objective was to analyze CS rates in Brazil according to source of payment for childbirth (public or private) using the Robson classification. METHODS: Data are from the 2011-2012 "Birth in Brazil" study, which used a national hospital-based sample of 23,940 women...
October 17, 2016: Reproductive Health
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