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https://www.readbyqxmd.com/read/28430892/anti-arrhythmic-potential-of-the-late-sodium-current-inhibitor-gs-458967-in-murine-scn5a-1798insd-and-human-scn5a-1795insd-ipsc-derived-cardiomyocytes
#1
Vincent Portero, Simona Casini, Maaike Hoekstra, Arie O Verkerk, Isabella Mengarelli, Luiz Belardinelli, Sridharan Rajamani, Arthur A M Wilde, Connie R Bezzina, Marieke W Veldkamp, Carol Ann Remme
AIM: Selective inhibition of cardiac late sodium current (INaL) is an emerging target in the treatment of ventricular arrhythmias. We investigated the electrophysiological effects of GS-458967 (GS967), a potent, selective inhibitor of INaL, in an overlap syndrome model of both gain and loss of sodium channel function, comprising cardiomyocytes derived from both human SCN5A-1795insD+/- induced pluripotent stem cells (hiPSC-CMs) and mice carrying the homologous mutation Scn5a-1798insD+/-...
April 18, 2017: Cardiovascular Research
https://www.readbyqxmd.com/read/28430487/population-mixing-in-asymmetric-magnetic-reconnection-with-a-guide-field
#2
M Hesse, L J Chen, Y-H Liu, N Bessho, J L Burch
We investigate how population mixing leads to structured electron distribution functions in asymmetric guide-field magnetic reconnection based on particle-in-cell simulations. The change of magnetic connectivity patches populations from different inflow regions to form multicomponent distributions in the exhaust, illustrating the direct consequence of the breaking and rejoining of magnetic flux tubes. Finite Larmor radius (FLR) effects of electrons accelerated by the perpendicular electric fields result in crescent-type nongyrotropic distributions...
April 7, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28430267/3d-cost-aggregation-with-multiple-minimum-spanning-trees-for-stereo-matching
#3
Lincheng Li, Xin Yu, Shunli Zhang, Xiaolin Zhao, Li Zhang
Cost aggregation is one of the key steps in the stereo matching problem. In order to improve aggregation accuracy, we propose a cost-aggregation method that can embed minimum spanning tree (MST)-based support region filtering into PatchMatch 3D label search rather than aggregating on fixed size patches. However, directly combining PatchMatch label search and MST filtering is not straightforward, due to the extremely high complexity. Thus, we develop multiple MST structures for cost aggregation on plenty of 3D labels, and design the tree-level random search strategy to find possible 3D labels of each pixel...
April 20, 2017: Applied Optics
https://www.readbyqxmd.com/read/28428804/morphogenesis-of-honeybee-hypopharyngeal-gland-during-pupal-development
#4
Sascha Peter Klose, Daniel Rolke, Otto Baumann
BACKGROUND: The hypopharyngeal gland of worker bees contributes to the production of the royal jelly fed to queens and larvae. The gland consists of thousands of two-cell units that are composed of a secretory cell and a duct cell and that are arranged in sets of about 12 around a long collecting duct. RESULTS: By fluorescent staining, we have examined the morphogenesis of the hypopharyngeal gland during pupal life, from a saccule lined by a pseudostratified epithelium to the elaborate organ of adult worker bees...
2017: Frontiers in Zoology
https://www.readbyqxmd.com/read/28428560/combination-of-high-density-microelectrode-array-and-patch-clamp-recordings-to-enable-studies-of-multisynaptic-integration
#5
David Jäckel, Douglas J Bakkum, Thomas L Russell, Jan Müller, Milos Radivojevic, Urs Frey, Felix Franke, Andreas Hierlemann
We present a novel, all-electric approach to record and to precisely control the activity of tens of individual presynaptic neurons. The method allows for parallel mapping of the efficacy of multiple synapses and of the resulting dynamics of postsynaptic neurons in a cortical culture. For the measurements, we combine an extracellular high-density microelectrode array, featuring 11'000 electrodes for extracellular recording and stimulation, with intracellular patch-clamp recording. We are able to identify the contributions of individual presynaptic neurons - including inhibitory and excitatory synaptic inputs - to postsynaptic potentials, which enables us to study dendritic integration...
April 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28427956/curcumin-poly-2-methyl-2-oxazoline-b-tetrahydrofuran-b-2-methyl-2-oxazoline-formulation-an-improved-penetration-and-biological-effect-of-curcumin-in-f508del-cftr-cell-lines
#6
Cristine Gonçalves, Jean-Pierre Gomez, William Même, Bazoly Rasolonjatovo, David Gosset, Steven Nedellec, Philippe Hulin, Cécile Huin, Tony Le Gall, Tristan Montier, Pierre Lehn, Chantal Pichon, Philippe Guégan, Hervé Cheradame, Patrick Midoux
Neutral amphiphilic triblock ABA copolymers are of great interest to solubilize hydrophobic drugs. We reported that a triblock ABA copolymer consisting of methyl-2-oxazoline (MeOx) and tetrahydrofuran (THF) (MeOx6-THF19-MeOx6) (TBCP2) can solubilize curcumin (Cur) a very hydrophobic molecule exhibiting multiple therapeutic effects but whose insolubility and low stability in water is a major drawback for clinical applications. Here, we provide evidences by flow cytometry and confocal microscopy that Cur penetration in normal and ΔF508-CFTR human airway epithelial cell lines is facilitated by TBCP2...
April 17, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28427818/a-necessary-condition-for-dispersal-driven-growth-of-populations-with-discrete-patch-dynamics
#7
Chris Guiver, David Packman, Stuart Townley
We revisit the question of when can dispersal-induced coupling between discrete sink populations cause overall population growth? Such a phenomenon is called dispersal driven growth and provides a simple explanation of how dispersal can allow populations to persist across discrete, spatially heterogeneous, environments even when individual patches are adverse or unfavourable. For two classes of mathematical models, one linear and one non-linear, we provide necessary conditions for dispersal driven growth in terms of the existence of a common linear Lyapunov function, which we describe...
April 17, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28427417/novel-trigenic-cacna1c-des-mypn-mutations-in-a-family-of-hypertrophic-cardiomyopathy-with-early-repolarization-and-short-qt-syndrome
#8
Yanhong Chen, Hector Barajas-Martinez, Dongxiao Zhu, Xihui Wang, Chonghao Chen, Ruijuan Zhuang, Jingjing Shi, Xueming Wu, Yijia Tao, Weidong Jin, Xiaoyan Wang, Dan Hu
BACKGROUND: Hypertrophic cardiomyopathy (HCM) patients with early repolarization (ER) pattern are at higher risk of ventricular arrhythmia, yet the genetic background of this situation has not been well investigated. Here we report novel trigenic mutations detected in a Chinese family of obstructive HCM with ER and short QT syndrome (SQTS). METHODS: Proband and family members underwent detailed medical assessments. DNAs were extracted from peripheral blood leukocytes for genetic screening with next generation method...
April 20, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28426550/neuropathic-pain-after-chronic-nerve-constriction-may-not-correlate-with-chloride-dysregulation-in-mouse-trigeminal-nucleus-caudalis-neurons
#9
Alberto Castro, Ying Li, Charles Raver, Ramesh Chandra, Radi Masri, Mary Kay Lobo, Asaf Keller
Changes in chloride reversal potential in rat spinal cord neurons have previously been associated with persistent pain in nerve injury and inflammation models. These changes correlate with a decrease in the expression of the potassium% chloride transporter, KCC2, and with increases in neuronal excitability. Here, we test the hypothesis that similar changes occur in mice with neuropathic pain induced by chronic constriction injury of the trigeminal infraorbital nerve (CCI¬-ION). This model allows us to distinguish an acute pain phase (3-¬5 days after injury) from a persistent pain phase (12¬-14 days after CCI-¬ION)...
April 18, 2017: Pain
https://www.readbyqxmd.com/read/28426442/amniotic-membrane-use-for-management-of-corneal-limbal-stem-cell-deficiency
#10
Alfonso L Sabater, Victor L Perez
PURPOSE OF REVIEW: The current article reviews the most recent surgical techniques for management of corneal limbal stem cell deficiency (LSCD) using amniotic membrane tissue. RECENT FINDINGS: Early successes with amniotic membrane transplantation (AMT) for the treatment of ocular surface disorders have encouraged clinicians to investigate new applications. The use of AMT as a temporary patch in emergency cases in which LSCD may develop has considerably improved the prognosis of these patients...
April 19, 2017: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/28426265/transdermal-iontophoresis-patch-with-reverse-electrodialysis
#11
Joon Lee, Kilsung Kwon, Minyoung Kim, Joonhong Min, Nathaniel S Hwang, Won-Serk Kim
Reverse electrodialysis (RED) technology generates energy from the salinity gradient by contacting waters with different salinity. Herein, we develop the disposable skin patch using this eco-friendly energy. The current density, which can be controlled easily without special circuit, is enough to iontophoretic drug delivery. In vitro study, this iontophoretic system enhanced the transdermal delivery of peptide, which is difficult to penetrate the skin barrier by simple diffusion. We design the disposable iontophoretic skin patch using RED system and suggest this patch can be apply on new cosmetic patch or disposable drug patch...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28425233/comparison-of-the-standard-gnrh-antagonist-protocol-and-the-luteal-phase-estradiol-gnrh-antagonist-priming-protocol-in-poor-ovarian-responders
#12
Mehmet Fırat Mutlu, İlknur Mutlu, Mehmet Erdem, İsmail Güler, Ahmet Erdem
BACKGROUND/AIM: The aim of the study was to compare the luteal estradiol patch/GnRH antagonists priming protocol (LPP) with the standard GnRH antagonist protocol in poor ovarian responders (PORs) in terms of the outcomes of in vitro fertilization (IVF) treatment. MATERIALS AND METHODS: IVF outcomes of 265 cycles in 265 patients (106 in the LPP group, 159 in the standard GnRH antagonist group) were evaluated retrospectively. RESULTS: Mean length of stimulation (11...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28425158/sexual-colouration-and-sperm-performance-in-the-australian-painted-dragon-lizard-ctenophorus-pictus
#13
Callum S McDiarmid, Christopher R Friesen, Cissy Ballen, Mats Olsson
Theory predicts trade-offs between pre- and postcopulatory sexually selected traits. This relationship may be mediated by the degree to which males are able to monopolise access to females, as this will place an upper limit on the strength of postcopulatory selection. Furthermore, traits that aid in mate monopolization may be costly to maintain and may limit investment in postcopulatory traits, such as sperm performance. Australian painted dragons are polymorphic for the presence or absence of a yellow gular patch ('bibs'), which may aid them to monopolise access to females...
April 20, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28425139/dissecting-cellulitis-of-the-scalp-with-excellent-response-to-isotretinoin
#14
Kaitlin Marquis, Laura-Catherine Christensen, Anand Rajpara
An 18-year-old man presented for evaluation of a 1-year history of painful nodules on the scalp with associated hair loss. Physical examination revealed multiple confluent, fluctuant, boggy nodules on the scalp with overlying alopecic patches. Based on these findings, a diagnosis of dissecting cellulitis of the scalp was made and the patient was successfully treated with oral isotretinoin therapy.
April 19, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/28425114/a-multi-institutional-joint-study-of-contact-dermatitis-related-to-hair-colouring-and-perming-agents-in-japan
#15
Akiko Ito, Kazue Nishioka, Hiromi Kanto, Akiko Yagami, Shigeki Yamada, Mariko Sugiura, Chihiro Yasunaga, Keiko Yoshii, Hiromi Kobayashi, Atsuko Adachi, Yuko Ikezawa, Kumiko Washizaki, Shigeki Inui, Hitoshi Miyazawa, Naoki Oiso, Tokio Nakata, Kayoko Matsunaga
BACKGROUND: In Japan, allergic contact dermatitis caused by hair colouring agents is a considerable problem for those occupationally exposed and also for consumers. Over the last 20 years, p-phenylenediamine (PPD) has been a common allergen, with ∼7% positive patch test reactions. OBJECTIVES: To investigate which ingredients caused allergic contact dermatitis related to hair dye and perming solutions in Japan, to assess whether PPD is suitable for screening for hair dye allergy, and to propose allergens for a Japanese hairdresser series...
April 20, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28425096/influence-of-coral-cover-and-structural-complexity-on-the-accuracy-of-visual-surveys-of-coral-reef-fish-communities
#16
D J Coker, J P Nowicki, N A J Graham
Using manipulated patch reefs with combinations of varying live-coral cover (low, medium and high) and structural complexity (low and high), common community metrics (abundance, diversity, richness and community composition) collected through standard underwater visual census techniques were compared with exhaustive collections using a fish anaesthetic (clove oil). This study showed that reef condition did not influence underwater visual census estimates at a community level, but reef condition can influence the detectability of some small and cryptic species and this may be exacerbated if surveys are conducted on a larger scale...
April 19, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28424726/size-mediated-interaction-between-a-cushion-species-and-other-non-cushion-species-at-high-elevations-of-the-hengduan-mountains-sw-china
#17
Yang Yang, Jian-Guo Chen, Christian Schöb, Hang Sun
Arenaria polytrichoides (Caryophyllaceae) is a common cushion plant occurring at high elevations in the Himalaya-Hengduan Mountains, SW China. It frequently has other non-cushion species growing within its canopy, forming a contrast with the surrounding areas because it creates patches of higher diversity and greater biomass. In this study, we examined the relationship between the cushions and associated non-cushion species along a gradient of cushion size. A total of 200 A. polytrichoides individuals were selected to fit four size classes...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28424588/chaperones-as-suppressors-of-protein-misfolded-oligomer-toxicity
#18
REVIEW
Benedetta Mannini, Fabrizio Chiti
Chaperones have long been recognized to play well defined functions such as to: (i) assist protein folding and promote formation and maintenance of multisubunit complexes; (ii) mediate protein degradation; (iii) inhibit protein aggregation; and (iv) promote disassembly of undesired aberrant protein aggregates. In addition to these well-established functions, it is increasingly clear that chaperones can also interact with aberrant protein aggregates, such as pre-fibrillar oligomers and fibrils, and inhibit their toxicity commonly associated with neurodegenerative diseases without promoting their disassembly...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28424398/-brodmann-areas-27-28-36-and-37-the-parahippocampal-and-the-fusiform-gyri
#19
Satoshi Eifuku
First, Brodmann areas 27, 28, 36 and 37, were anatomically defined in the beginning of this review. These areas exist in the parahippocampal or fusiform gyrus of the ventral temporal lobe in humans. Subsequently, the current understanding of their functions was summarized on the basis of recent findings mainly through human functional neuroimaging studies and animal studies. Rodent studies have shown the existence of neuronal activities for representing space, such as those involving head-direction cells or grid cells, in areas 27 (the parasubicular cortex) and 28 (the ventral entorhinal cortex)...
April 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28424345/floaters-may-buffer-the-extinction-risk-of-small-populations-an-empirical-assessment
#20
Hugo Robles, Carlos Ciudad
The high extinction risk of small populations is commonly explained by reductions in fecundity and breeder survival associated with demographic and environmental stochasticity. However, ecological theory suggests that population extinctions may also arise from reductions in the number of floaters able to replace the lost breeders. This can be particularly plausible under harsh fragmentation scenarios, where species must survive as small populations subjected to severe effects of stochasticity. Using a woodpecker study in fragmented habitats (2004-2016), we provide here empirical support for the largely neglected hypothesis that floaters buffer population extirpation risks...
April 26, 2017: Proceedings. Biological Sciences
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